M J Nunes, A N Carvalho, C Sá-Lemos, M Colaço, I Cervenka, V Ciraci, S G Santos, M M Ribeiro, M Castanheira, P R Jannig, M J Gama, M Castro-Caldas, C M P Rodrigues, E Rodrigues, J L Ruas
Peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) transcriptional coactivators are key regulators of energy metabolism-related genes and are expressed in energy-demanding tissues. There are several PGC-1α variants with different biological functions in different tissues. The brain is one of the tissues where the role of PGC-1α isoforms remains less explored. Here, we used a toxin-based mouse model of Parkinson's disease (PD) and observed that the expression levels of variants PGC-1α2 and PGC-1α3 in the nigrostriatal pathway increases at the onset of dopaminergic cell degeneration...
November 19, 2023: European Journal of Cell Biology