journal
MENU ▼
Read by QxMD icon Read
search

Trends in Pharmacological Sciences

journal
https://www.readbyqxmd.com/read/28214012/the-endothelium-solves-problems-that-endothelial-cells-do-not-know-exist
#1
REVIEW
John G McCarron, Matthew D Lee, Calum Wilson
The endothelium is the single layer of cells that lines the entire cardiovascular system and regulates vascular tone and blood-tissue exchange, recruits blood cells, modulates blood clotting, and determines the formation of new blood vessels. To control each function, the endothelium uses a remarkable sensory capability to continuously monitor vanishingly small changes in the concentrations of many simultaneously arriving extracellular activators that each provides cues to the physiological state. Here we suggest that the extraordinary sensory capabilities of the endothelium do not come from single cells but from the combined activity of a large number of endothelial cells...
February 14, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28209404/cell-penetrating-peptides-from-basic-research-to-clinics
#2
REVIEW
Giulia Guidotti, Liliana Brambilla, Daniela Rossi
The presence of cell and tissue barriers together with the low biomembrane permeability of various therapeutics often hampers systemic drug distribution; thus, most of the available molecules are of limited therapeutic value. Opportunities to increase medicament concentrations in areas that are difficult to access now exist with the advent of cell-penetrating peptides (CPPs), which can transport into the cell a wide variety of biologically active conjugates (cargoes). Numerous preclinical evaluations with CPP-derived therapeutics have provided promising results in various disease models that, in some cases, prompted clinical trials...
February 13, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28209403/small-molecules-that-sabotage-bacterial-virulence
#3
REVIEW
Benjamin K Johnson, Robert B Abramovitch
The continued rise of antibiotic-resistant bacterial infections has motivated alternative strategies for target discovery and treatment of infections. Antivirulence therapies function through inhibition of in vivo required virulence factors to disarm the pathogen instead of directly targeting viability or growth. This approach to treating bacteria-mediated diseases may have advantages over traditional antibiotics because it targets factors specific for pathogenesis, potentially reducing selection for resistance and limiting collateral damage to the resident microbiota...
February 13, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28188005/g-protein-gated-potassium-channels-a-link-to-drug-addiction
#4
REVIEW
Robert A Rifkin, Stephen J Moss, Paul A Slesinger
G protein-gated inwardly rectifying potassium (GIRK) channels are regulators of neuronal excitability in the brain. Knockout mice lacking GIRK channels display altered behavioral responses to multiple addictive drugs, implicating GIRK channels in addictive behaviors. Here, we review the effects of GIRK subunit deletions on the behavioral response to psychostimulants, such as cocaine and methamphetamine. Additionally, exposure of mice to psychostimulants produces alterations in the surface expression of GIRK channels in multiple types of neurons within the reward system of the brain...
February 7, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28169001/emerging-approaches-to-tuberculosis-drug-development-at-home-in-the-metabolome
#5
REVIEW
Robert S Jansen, Kyu Y Rhee
Once considered a crowning achievement of modern drug development, tuberculosis (TB) chemotherapy has proven increasingly unable to keep pace with the spread of the pandemic and rise of drug resistance. Efforts to revive the TB drug development pipeline have, in the meantime, faltered. Closer analysis reveals key experimental deficiencies that have hindered our ability to 'reverse engineer' knowledge of antibiotic mechanisms into rational drug development. Here, we discuss the emerging potential of metabolomics; the systems level study of small molecule metabolites, to help overcome these gaps and serve as a unique biochemical bridge between the phenotypic properties of chemical compounds and biological targets...
February 3, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28162792/synthetic-pot-not-your-grandfather-s-marijuana
#6
REVIEW
Benjamin M Ford, Sherrica Tai, William E Fantegrossi, Paul L Prather
In the early 2000s in Europe and shortly thereafter in the USA, it was reported that 'legal' forms of marijuana were being sold under the name K2 and/or Spice. Active ingredients in K2/Spice products were determined to be synthetic cannabinoids (SCBs), producing psychotropic actions via CB1 cannabinoid receptors, similar to those of Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the primary active constituent in marijuana. Often abused by adolescents and military personnel to elude detection in drug tests due to their lack of structural similarity to Δ(9)-THC, SCBs are falsely marketed as safe marijuana substitutes...
January 27, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28139258/targeting-class-i-histone-deacetylases-in-a-complex-environment
#7
REVIEW
Christopher J Millard, Peter J Watson, Louise Fairall, John W R Schwabe
Histone deacetylase (HDAC) inhibitors are proven anticancer therapeutics and have potential in the treatment of many other diseases including HIV infection, Alzheimer's disease, and Friedreich's ataxia. A problem with the currently available HDAC inhibitors is that they have limited specificity and target multiple deacetylases. Designing isoform-selective inhibitors has proven challenging due to similarities in the structure and chemistry of HDAC active sites. However, the fact that HDACs 1, 2, and 3 are recruited to several large multi-subunit complexes, each with particular biological functions, raises the possibility of specifically inhibiting individual complexes...
January 27, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28126382/complex-pathologic-roles-of-ripk1-and-ripk3-moving-beyond-necroptosis
#8
REVIEW
Kelby W Wegner, Danish Saleh, Alexei Degterev
A process of regulated necrosis, termed necroptosis, has been recognized as a major contributor to cell death and inflammation occurring under a wide range of pathologic settings. The core event in necroptosis is the formation of the detergent-insoluble 'necrosome' complex of homologous Ser/Thr kinases, receptor protein interacting kinase 1 (RIPK1) and receptor interacting protein kinase 3 (RIPK3), which promotes phosphorylation of a key prodeath effector, mixed lineage kinase domain-like (MLKL), by RIPK3. Core necroptosis mediators are under multiple controls, which have been a subject of intense investigation...
January 23, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28118935/g-protein-coupled-receptors-in-myelinating-glia-trends-in-pharmacological-sciences-37-977-987-2016
#9
Amit Mogha, Mitchell D'Rozario, Kelly R Monk
No abstract text is available yet for this article.
January 21, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28111068/printed-drug-delivery-systems-for-improved-patient-treatment-trends-in-pharmacological-sciences-37-1070-1080
#10
Niklas Sandler, Maren Preis
No abstract text is available yet for this article.
January 19, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28095988/modern-history-of-medical-cannabis-from-widespread-use-to-prohibitionism-and-back
#11
Simona Pisanti, Maurizio Bifulco
No abstract text is available yet for this article.
January 14, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28089139/cannabidiol-claims-and-misconceptions
#12
Ethan B Russo
Once a widely ignored phytocannabinoid, cannabidiol now attracts great therapeutic interest, especially in epilepsy and cancer. As with many rising trends, various myths and misconceptions have accompanied this heightened public interest and intrigue. This forum article examines and attempts to clarify some areas of contention.
January 11, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28017363/statins-for-primary-prevention-of-cardiovascular-disease
#13
Giuseppe Lippi, Mario Plebani
The US Preventive Services Task Force has recently recommended the use of statins in primary prevention of cardiovascular disease in adults. Doubts remain as to whether this approach is really cost-effective, and additional drawbacks include the increasing burden of potential side effects and incremental costs due to laboratory monitoring.
December 22, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28017362/brain-pericytes-as-mediators-of-neuroinflammation
#14
REVIEW
Justin Rustenhoven, Deidre Jansson, Leon C Smyth, Mike Dragunow
Brain pericytes are perivascular cells that regulate capillary function, and this localization puts them in a pivotal position for the regulation of central nervous system (CNS) inflammatory responses at the neurovascular unit. Neuroinflammation, driven by microglia and astrocytes or resulting from peripheral leukocyte infiltration, has both homeostatic and detrimental consequences for brain function and is present in nearly every neurological disorder. More recently, brain pericytes have been shown to have many properties of immune regulating cells, including responding to and expressing a plethora of inflammatory molecules, presenting antigen, and displaying phagocytic ability...
December 22, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28012700/heat-shock-proteins-and-cancer
#15
REVIEW
Jianming Wu, Tuoen Liu, Zechary Rios, Qibing Mei, Xiukun Lin, Shousong Cao
Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding and maturation whose expression is induced by heat shock or other stressors. The major groups are classified based on their molecular weights and include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. HSPs play a significant role in cellular proliferation, differentiation, and carcinogenesis. In this article we comprehensively review the roles of major HSPs in cancer biology and pharmacology. HSPs are thought to play significant roles in the molecular mechanisms leading to cancer development and metastasis...
December 21, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27989503/a-purinergic-trail-for-metastases
#16
REVIEW
Davide Ferrari, Fabio Malavasi, Luca Antonioli
Nucleotides and nucleosides have emerged as important modulators of tumor biology. Recently acquired evidence shows that, when these molecules are released by cancer cells or surrounding tissues, they act as potent prometastatic factors, favoring tumor cell migration and tissue colonization. Therefore, nucleotides and nucleosides should be considered as a new class of prometastatic factors. In this review, we focus on the prometastatic roles of nucleotides and discuss future applications of purinergic signaling modulation in view of antimetastatic therapies...
December 15, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27939446/classification-systems-of-secondary-active-transporters
#17
REVIEW
Emelie Perland, Robert Fredriksson
Membrane-bound solute carrier (SLC) transporter proteins are vital to the human body, as they sustain homeostasis by moving soluble molecule as nutrients, drugs, and waste across lipid membranes. Of the 430 identified secondary active transporters in humans, 30% are still orphans, and systematic research has been requested to elaborate on their possible involvement in diseases and their potential as drug targets. To enable this, the various classification systems in use must be understood and used correctly...
December 8, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27916280/novel-targeted-therapies-for-inflammatory-bowel-disease
#18
REVIEW
Mehmet Coskun, Severine Vermeire, Ole Haagen Nielsen
Our growing understanding of the immunopathogenesis of inflammatory bowel disease (IBD) has opened new avenues for developing targeted therapies. These advances in treatment options targeting different mechanisms of action offer new hope for personalized management. In this review we highlight emerging novel and easily administered therapeutics that may be viable candidates for the management of IBD, such as antibodies against interleukin 6 (IL-6) and IL-12/23, small molecules including Janus kinase inhibitors, antisense oligonucleotide against SMAD7 mRNA, and inhibitors of leukocyte trafficking to intestinal sites of inflammation (e...
February 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27916279/insights-from-preclinical-choice-models-on-treating-drug-addiction
#19
REVIEW
Matthew L Banks, S Stevens Negus
Substance-use disorders are a global public health problem that arises from behavioral misallocation between drug use and more adaptive behaviors maintained by nondrug alternatives (e.g., food or money). Preclinical drug self-administration procedures that incorporate a concurrently available nondrug reinforcer (e.g., food) provide translationally relevant and distinct dependent measures of behavioral allocation (i.e., to assess the relative reinforcing efficacy of the drug) and behavioral rate (i.e., to assess motor competence)...
February 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27890353/anxiety-and-nicotine-dependence-emerging-role-of-the-habenulo-interpeduncular-axis
#20
REVIEW
Susanna Molas, Steven R DeGroot, Rubing Zhao-Shea, Andrew R Tapper
While innovative modern neuroscience approaches have aided in discerning brain circuitry underlying negative emotional behaviors including fear and anxiety responses, how these circuits are recruited in normal and pathological conditions remains poorly understood. Recently, genetic tools that selectively manipulate single neuronal populations have uncovered an understudied circuit, the medial habenula (mHb)-interpeduncular (IPN) axis, that modulates basal negative emotional responses. Interestingly, the mHb-IPN pathway also represents an essential circuit that signals heightened anxiety induced by nicotine withdrawal...
February 2017: Trends in Pharmacological Sciences
journal
journal
27678
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"