Glen K Miller, Sabu Kuruvilla, Binod Jacob, Lisa LaFranco-Scheuch, Vasudevan Bakthavatchalu, Jason Flor, Kristin Flor, Julie Ziegler, Christine Reichard, Phil Manfre, Suzanne Firner, Tara McNutt, Diane Quay, Sairam Bellum, Greg Doto, Paul J Ciaccio, Kara Pearson, Jack Valentine, Pete Fuller, Matt Fell, Takayuki Tsuchiya, Toni Williamson, Gordon Wollenberg
Toxicology studies in nonhuman primates were conducted to evaluate selective, brain penetrant inhibitors of LRRK2. GNE 7915 was limited to 7-day administration in cynomolgus monkeys at 65 mg/kg/day or limited to 14 days in rhesus at 22.5 mg/kg b.i.d. due to physical signs. Compound 25 demonstrated acceptable tolerability at 50 and 225 mg/kg b.i.d. for 7 days in rhesus monkeys. MK-1468 was tolerated during 7-day administration at 100, 200 or 800 mg/kg/day or for 30-day administration at 30, 100, or 500 mg/kg b...
November 2, 2023: Toxicologic Pathology