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Journal of Inorganic Biochemistry

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https://www.readbyqxmd.com/read/28095346/crystal-structure-cytotoxicity-and-action-mechanism-of-zn-ii-mn-ii-complexes-with-isoquinoline-ligands
#1
Feng-Yang Wang, Qian-Yu Xi, Ke-Bin Huang, Xiao-Ming Tang, Zhen-Feng Chen, Yan-Cheng Liu, Hong Liang
Four μ2-Cl bridged dinuclear metal complexes with isoquinoline ligands, (MPDQ)2Zn2Cl4 (1) (MPDQ=4.5-methylenedioxy-1-pyridinedihydroisoquinoline), (PYP)2Zn2Cl4 (2) (PYP=5-pyridin-2-yl-[1,3]dioxolo[4,5-g]isoquinoline), (MPDQ)2Mn2Cl4 (3),and (PYP)2Mn2Cl4 (4) were synthesized and characterized. All complexes exhibited strong proliferation inhibition activity against various cancer cells. The underlying molecular mechanisms through which they caused the cancer cell death were also elucidated. Induction of apoptosis in MGC-803 cells by complex 2 was evidenced by annexin V(+)/PI(-) detection and DiD/DAPI staining assay...
January 6, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28088013/delineating-hierarchy-of-selenotranscriptome-expression-and-their-response-to-selenium-status-in-chicken-central-nervous-system
#2
Xiu-Qing Jiang, Chang-Yu Cao, Zhao-Yang Li, Wei Li, Cong Zhang, Jia Lin, Xue-Nan Li, Jing-Long Li
Selenium (Se) incorporated in selenoproteins as selenocysteine and supports various important cellular and organismal functions. We recently reported that chicken brain exhibited high priority for Se supply and retention under conditions of dietary Se deficiency and supernutrition Li et al. (2012) . However, the selenotranscriptome expressions and their response to Se status in chicken central nervous system (CNS) are unclear. To better understand the relationship of Se homeostasis and selenoproteins expression in chicken CNS, 1day-old HyLine White chickens were fed a low Se diet (Se-L, 0...
January 4, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28024186/synthesis-characterization-dna-interactions-and-antiproliferative-activity-on-glioblastoma-of-iminopyridine-platinum-ii-chelate-complexes
#3
Inmaculada Posadas, Carlos Alonso-Moreno, Iván Bravo, Fernando Carrillo-Hermosilla, Andrés Garzón, Noemí Villaseca, Isabel López-Solera, José Albaladejo, Valentín Ceña
A series of iminopyridine platinum chelate compounds has been prepared and characterized by NMR spectroscopy and single-crystal X-ray diffraction. The complexes were evaluated in C6 tumoral cells as an in vitro model for glioblastoma multiforme. The DNA-binding properties of these complexes were studied by UV-Vis absorption and fluorescence spectroscopy and Density Functional Theory calculations were performed in an effort to rationalize the observed properties at the molecular level. The most promising drug candidate displayed a similar potency in inducing cell death to the clinically used reference compound and showed significant inhibition of glioblastoma cell proliferation...
December 19, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28024187/synthesis-photophysical-properties-and-structures-of-organotin-schiff-bases-utilizing-aromatic-amino-acid-from-the-chiral-pool-and-evaluation-of-the-biological-perspective-of-a-triphenyltin-compound
#4
Tushar S Basu Baul, Pelesakuo Kehie, Andrew Duthie, Nikhil Guchhait, Nune Raviprakash, Raveendra B Mokhamatam, Sunil K Manna, Nerina Armata, Michelangelo Scopelliti, Ruimin Wang, Ulli Englert
Five new organotin(IV) complexes of compositions [Me2SnL(1)] (1), [Me2SnL(2)]n (2), [Me2SnL(3)] (3), [Ph3SnL(1)H]n (4) and [Ph3SnL(3)H] (5) (where L(1)=(2S)-2-((E)-((Z)-4-hydroxypent-3-en-2-ylidene)amino)-3-(1H-indol-3-yl)propanoate, L(2)=(2S)-(E)-2-((2-hydroxybenzylidene)amino)-3-(1H-indol-3-yl)propanoate and L(3)=(2S)-(E)-2-((1-(2-hydroxyphenyl)ethylidene)amino)-3-(1H-indol-3-yl)propanoate were synthesized and spectroscopically characterized. The crystal structures of 1-4 were determined. For the dimethyltin derivative 2, a polymeric chain structure was observed as a result of a long Sn∙∙∙O contact involving the exocyclic carbonyl oxygen-atom from the tridentate ligand of a neighboring Sn-complex unit...
December 16, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28013066/antileukemic-activity-of-an-arsenomolybdate-in-the-human-hl-60-and-u937-leukemia-cells
#5
Chunyan Li, Hongqian Cao, Jiaheng Sun, Rui Tian, Dongbei Li, Yanfei Qi, Wei Yang, Juan Li
The antileukemic activity, mechanisms and serum albumin interactions of an arsenomolybdate, K2Na[AsMo6O21(O2CCH2NH3)3]·6H2O (1), was evaluated in the human leukemia HL-60 and U937 cells. The results indicated that 1 could inhibit the proliferation of both leukemia cell lines in a dose-dependent manner with the 50% lethal concentration (IC50) value of 8.61μM for HL-60 and 14.50μM for U937 at 24h, compare to the positive controls, all-trans retinoic acid (ATRA) with IC50 value of 20.76μM and 14.85μM,and As2O3 with IC50 value of 6...
December 16, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28013065/an-unlikely-dna-cleaving-agent-a-photo-active-trinuclear-cu-ii-complex-based-on-hexaazatriphenylene
#6
Dominique E Williams, Christina M Fischer, Miki Kassai, Lourdes Gude, María-José Fernández, Antonio Lorente, Kathryn B Grant
This paper describes the synthesis of a trinuclear Cu(II) complex (4) containing a central 1,4,5,8,9,12-hexaazatriphenylene-hexacarboxylate (hat) core (3). Low, micromolar concentrations of the negatively charged parent ligand 3 and the neutral trinuclear complex 4 were found to photocleave negatively charged pUC19 plasmid DNA with high efficiency at neutral pH (350nm, 50min, 22°C). The interactions of complex 4 with double-helical DNA were studied in detail. Scavenger and colorimetric assays pointed to the formation of Cu(I), superoxide anion radicals, hydrogen peroxide, and hydroxyl radicals during photocleavage reactions...
December 15, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27997856/new-silver-complexes-with-bioactive-glycine-and-nicotinamide-molecules-characterization-dna-binding-antimicrobial-and-anticancer-evaluation
#7
Michaela Rendošová, Zuzana Vargová, Juraj Kuchár, Danica Sabolová, Štefan Levoča, Júlia Kudláčová, Helena Paulíková, Daniela Hudecová, Veronika Helebrandtová, Miroslav Almáši, Mária Vilková, Michal Dušek, Dáša Bobáľová
This study introduces a pair of newly synthesized silver complexes, [Ag2(HGly)2]n(NO3)2n (1) and [Ag(Nam)2]NO3·H2O (2) (Gly - glycine, Nam - nicotinamide), that were prepared and characterized by relevant methods in solid state (elemental, spectral, thermal and structural analysis) and their stability in solution was verified by (1)H NMR measurements. Moreover, suitable reaction conditions were observed by potentiometry depending on pH in case of binary system Ag-Gly. X-ray analysis confirmed argentophilic interactions in complex 1 with an Ag1-Ag2 distance of 2...
December 15, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28006663/studies-on-the-mechanism-of-action-of-antitumor-bis-aminophenolate-ruthenium-iii-complexes
#8
Orsolya Dömötör, Rodrigo F M de Almeida, Leonor Côrte-Real, Cristina P Matos, Fernanda Marques, António Matos, Carla Real, Tamás Kiss, Éva Anna Enyedy, M Helena Garcia, Ana Isabel Tomaz
Two recently published Ru(III) complexes bearing (N2O2) tetradentate bis(aminophenolate) ligands, formulated as [Ru(III)(salan)(PPh3)Cl] (salan is the tetradentate ligand 6,6'-(1S,2S)-cyclohexane-1,2-diylbis(azanediyl)bis(methylene)bis(3-methoxyphenol) in complex 1, or 2,2'-(1S,2S)-cyclohexane-1,2-diylbis(azanediyl)bis(methylene)bis(4-methoxyphenol) in complex 2; PPh3 is triphenylphosphane) and found very active against ovarian and breast adenocarcinoma human cells were studied to outline their antitumor mode of action...
December 14, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28006662/potent-anticancer-activity-of-a-new-bismuth-iii-complex-against-human-lung-cancer-cells
#9
Ruizhuo Ouyang, Yang Yang, Xiao Tong, Kai Feng, Yaoqin Yang, Huihong Tao, Xiaoshen Zhang, Tianyu Zong, Penghui Cao, Fei Xiong, Ning Guo, Yuhao Li, Yuqing Miao, Shuang Zhou
The aim of this work is experimental study of an interesting bismuth(III) complex derived from pentadentate 2,6-pyridinedicarboxaldehyde bis((4)N-methylthiosemicarbazone), [BiL(NO3)2]NO3 {L=2,6-pyridinedicarboxaldehyde bis((4)N-methylthiosemicarbazone)}. A series of in vitro biological studies indicate that the newly prepared [BiL(NO3)2]NO3 greatly suppressed colony formation, migration and significantly induced apoptosis of human lung cancer cells A549 and H460, but did not obviously decrease the cell viability of non-cancerous human lung fibroblast (HLF) cell line, showing much higher anticancer activities than its parent ligands, especially with half maximum inhibitory concentration (IC50) <3...
December 11, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28086144/synthesis-spectral-characterization-of-novel-pd-ii-pt-ii-%C3%AF-coordination-compounds-based-on-n-allylthioureas-cytotoxic-properties-and-dna-binding-ability
#10
H H Repich, V V Orysyk, L G Palchykovska, S I Orysyk, Yu L Zborovskii, O V Vasylchenko, O V Storozhuk, A A Biluk, V V Nikulina, L V Garmanchuk, V I Pekhnyo, M V Vovk
Four novel Pd(2+) and Pt(2+) mononuclear π-coordination compounds with general formula [M(HL)(1,2)Cl2], M=Pd(2+), Pt(2+) have been synthesized by reaction of [PdCl4](2-), [PtCl4](2-) anions with N-allyl-4-morpholinethiocarboxamide (HL(1)) and N-Allyl-N'-tert-butylthiourea (HL(2)). All complexes have been characterized by single-crystal X-ray diffraction study and (1)H, (13)C NMR spectroscopy. Cytotoxic, cytostatic and proapoptotic activities of compounds have been determined in vitro on HeLa cell line and compared with cisplatin as etalon drug...
December 10, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28011210/synergistic-antibacterial-effect-of-bi2s3-nanospheres-combined-with-ineffective-antibiotic-gentamicin-against-methicillin-resistant-staphylococcus-aureus
#11
Lulu Ma, Jie Wu, Shilei Wang, Hao Yang, Donghui Liang, Zhong Lu
In this paper, Bi2S3 nanospheres with size of 212nm were prepared by a simple hydrothermal process. The selectively enhanced antibacterial effects of Bi2S3 nanospheres with three classes of ineffective antibiotics, β-lactam (cefuroxime, CXM; cefotaxime, CTX and piperacillin, PIP), quinolone (ciprofloxacin, CIP) and aminoglycoside (gentamicin, GEN) against clinical isolated methicillin-resistant Staphylococcus aureus (MRSA) were investigated for the first time. GEN shows significantly synergistic growth inhibition against MRSA when combined with Bi2S3 nanospheres, while CXM, CTX, PIP and CIP do not...
December 10, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27997857/silver-complexes-of-ligands-derived-from-adamantylamines-water-soluble-silver-donating-compounds-with-antibacterial-properties
#12
Jorge Jimenez, Indranil Chakraborty, Mauricio Rojas-Andrade, Pradip K Mascharak
Two new silver(I) complexes, namely [Ag(qyAm)2](CF3SO3) (1) and [Ag(qyTAm)2](CF3SO3) (2), (qyAm=2-(quinonyl)iminoadamantane, qyTAm=2-(quinonyl)iminotriazaadamantane) have been synthesized and characterized by elemental analyses, (1)H NMR, IR, electronic absorption spectroscopy, and X-ray diffraction. The coordination geometry of the silver center in both complexes is distorted tetrahedral where their respective qyAm and qyTAm ligand bind in a bidentate fashion using the imine and quinoline nitrogen atoms. Complex 2 is soluble in water and exhibits strong antimicrobial actions on both Gram-negative (E...
December 10, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28064102/influence-of-components-of-tumour-microenvironment-on-the-response-of-hct-116-colorectal-cancer-to-the-ruthenium-based-drug-nami-a
#13
Alberta Bergamo, Chiara Pelillo, Angela Chambery, Gianni Sava
Solid tumours are constituted of tumour cells, healthy cells recruited from the host tissues and soluble factors released by both these cell types. The present investigation examines the capacity of co-cultures between the HCEC colon epithelial cells and the HCT-116 colorectal cancer cells (mimicking the primary site of tumour growth) and between IHH hepatocytes and the HCT-116 colorectal cancer cells (metastatic site) to influence the effects of NAMI-A (imidazolium trans-imidazoledimethylsulphoxidetetrachloro ruthenate) on the tumour cells themselves...
December 2, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27984786/enhancement-of-antibiotic-activity-through-complexation-with-metal-ions-combined-itc-nmr-enzymatic-and-biological-studies
#14
Jasper S Möhler, Theresa Kolmar, Kevin Synnatschke, Marcel Hergert, Liam A Wilson, Soumya Ramu, Alysha G Elliott, Mark A T Blaskovich, Hanna E Sidjabat, David L Paterson, Gerhard Schenk, Matthew A Cooper, Zyta M Ziora
Alternative solutions need to be developed to overcome the growing problem of multi-drug resistant bacteria. This study explored the possibility of creating complexes of antibiotics with metal ions, thereby increasing their activity. Analytical techniques such as isothermal titration calorimetry and nuclear magnetic resonance were used to examine the structure and interactions between Cu(II), Ag(I) or Zn(II) and β-lactam antibiotics. The metal-β-lactam complexes were also tested for antimicrobial activity, by micro-broth dilution and disk diffusion methods, showing a synergistic increase in the activity of the drugs, and enzymatic inhibition assays confirming inhibition of β-lactamases responsible for resistance...
February 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27974280/characterization-of-the-second-conserved-domain-in-the-heme-uptake-protein-htaa-from-corynebacterium-diphtheriae
#15
Rizvan C Uluisik, Neval Akbas, Gudrun S Lukat-Rodgers, Seth A Adrian, Courtni E Allen, Michael P Schmitt, Kenton R Rodgers, Dabney W Dixon
HtaA is a heme-binding protein that is part of the heme uptake system in Corynebacterium diphtheriae. HtaA contains two conserved regions (CR1 and CR2). It has been previously reported that both domains can bind heme; the CR2 domain binds hemoglobin more strongly than the CR1 domain. In this study, we report the biophysical characteristics of HtaA-CR2. UV-visible spectroscopy and resonance Raman experiments are consistent with this domain containing a single heme that is bound to the protein through an axial tyrosine ligand...
February 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27974279/sequestering-ability-to-cu-2-of-a-new-bodipy-based-dye-and-its-behavior-as-in-vitro-fluorescent-sensor
#16
Teresa Papalia, Anna Barattucci, Davide Barreca, Ersilia Bellocco, Paola Bonaccorsi, Lucio Minuti, Marco Sebastiano Nicolò, Andrea Temperini, Claudia Foti
A Bodipy (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) derivative has been conceived and synthesized starting from l-aspartic acid, as a selective turn-off sensor of Cu(2+) ions. Its acid-base properties were determined to study the formation of metal/sensor complex species by titration of solutions each containing a different metal ion, such as Cu(2+), Ca(2+), Zn(2+), Pb(2+) and Hg(2+) and different metal/sensor ratios. The speciation models allowed us to simulate the distribution of the metal/sensor complex species at the normal concentrations of the corresponding metals present in biological fluids...
February 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27919007/challenges-in-assignment-of-allosteric-effects-in-cytochrome-p450-catalyzed-substrate-oxidations-to-structural-dynamics-in-the-hemoprotein-architecture
#17
Peter Hlavica
Cytochrome P450s (CYP) represent a superfamily of b-type hemoproteins catalyzing NAD(P)H-dependent oxidative biotransformation of a vast array of natural and xenobiotic compounds. Many eu- and prokaryotic members of this class of monooxygenases display complex non-Michaelis-Menten saturation kinetics, suggestive of homo-/heterotropic cooperativity arising from substrate-/effector-induced allosteric interactions. Here, the paradigm of multiple-ligand occupancy of the catalytic pocket in combination with enzyme oligomerization provides the most favored explanations for the atypical kinetic patterns...
February 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27915178/anticancer-copper-pyridine-benzimidazole-complexes-ros-generation-biomolecule-interactions-and-cytotoxicity
#18
Kathleen E Prosser, Stephanie W Chang, Felix Saraci, Phuc H Le, Charles J Walsby
The Cu(II) complex CuCl2(pbzH), pbzH=2-(2-pyridyl)benzimidazole, and derivatives modified at the non-coordinated nitrogen of the benzimidazole fragment, have been studied as anticancer agents. These compounds show promising cytotoxicity against A549 adenocarcinomic alveolar basal epithelial cells with IC50 values in the range of 5-10μM. Importantly, this activity is higher than either CuCl2·2H2O or the individual ligands, demonstrating that ligand coordination to the Cu(II) centres of the complexes is required for full activity...
February 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27912082/low-dimensional-compounds-containing-bioactive-ligands-part-viii-dna-interaction-antimicrobial-and-antitumor-activities-of-ionic-5-7-dihalo-8-quinolinolato-palladium-ii-complexes-with-k-and-cs-cations
#19
Veronika Farkasová, Sayed Ali Drweesh, Andrea Lüköová, Danica Sabolová, Ivana D Radojević, Ljiljana R Čomić, Sava M Vasić, Helena Paulíková, Stanislav Fečko, Tatiana Balašková, Mária Vilková, Ján Imrich, Ivan Potočňák
Starting from well-defined NH2(CH3)2[PdCl2(XQ)] complexes, coordination compounds of general formula Cat[PdCl2(XQ)] have been prepared by cationic exchange of NH2(CH3)2(+) and Cat cations, where XQ are biologically active halogen derivatives of quinolin-8-ol (5-chloro-7-iodo-quinolin-8-ol (CQ), 5,7-dibromo-quinolin-8-ol (dBrQ) and 5,7-dichloro-quinolin-8-ol (dClQ)) and Cat is K(+) or Cs(+). The cation exchange of all prepared complexes, K[PdCl2(CQ)] (1), K[PdCl2(dClQ)] (2), K[PdCl2(dBrQ)] (3), Cs[PdCl2(CQ)] (4), Cs[PdCl2(dClQ)] (5) and Cs[PdCl2(dBrQ)] (6) was approved using IR spectroscopy, their structures in DMSO solution were elucidated by one- and two-dimensional NMR experiments, whereas their stability in solution was verified by UV-VIS spectroscopy...
February 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27907865/biophysical-characterization-and-antineoplastic-activity-of-new-bis-thiosemicarbazonato-cu-ii-complexes
#20
Elisa Palma, Filipa Mendes, Goreti Ribeiro Morais, Inês Rodrigues, Isabel Cordeiro Santos, Maria Paula C Campello, Paula Raposinho, Isabel Correia, Sofia Gama, Dulce Belo, Vítor Alves, Antero J Abrunhosa, Isabel Santos, António Paulo
Aiming to explore alternative mechanisms of cellular uptake and cytotoxicity, we have studied a new family of copper(II) complexes (CuL(1)-CuL(4)) with bis(thiosemicarbazone) (BTSC) ligands containing pendant protonable cyclic amines (morpholine and piperidine). Herein, we report on the synthesis and characterization of these new complexes, as well as on their biological performance (cytotoxic activity, cellular uptake, protein and DNA binding), in comparison with the parental Cu(II)ATSM (ATSM=diacetyl-bis(N4-methylthiosemicarbazonate) complex without pendant cyclic amines...
February 2017: Journal of Inorganic Biochemistry
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