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Journal of Inorganic Biochemistry

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https://www.readbyqxmd.com/read/29329027/cytotoxic-and-anticancer-properties-of-new-ruthenium-polypyridyl-complexes-with-different-lipophilicities
#1
Anjong Florence Tikum, Yu Jeong Jeon, Ju Hyun Lee, Min Hee Park, In Yeong Bae, Sang Heon Kim, Hye Jin Lee, Jinheung Kim
Three ruthenium complexes containing a bidentate piq ligand, [(piq)Ru(bpy)2]2+ (1), [(piq)Ru(phen)2]2+ (2), and [(piq)Ru(DIP)2]2+ (3) (piq = phenylisoquinolinate, bpy = 2,2'-bipyridine, phen = 1,10-phenanthroline, DIP = 4,7-diphenyl-1,10-phenanthroline), were prepared. The DNA binding properties of complexes 1-3 to double-stranded DNA were studied. The binding of 1-3 to calf-thymus DNA (ct-DNA) yielded lower emission intensities than those observed with the corresponding Ru complexes alone. To explore potential interactions of complexes 1-3 with lipid-rich organs in live cells, the emission properties of the Ru probes were studied with liposomes...
January 9, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29324291/disulfide-masked-iron-prochelators-effects-on-cell-death-proliferation-and-hemoglobin-production
#2
E A Akam, R D Utterback, J R Marcero, H A Dailey, E Tomat
The iron metabolism of malignant cells, which is altered to ensure higher acquisition and utilization, motivates the investigation of iron chelation strategies in cancer treatment. In a prochelation approach aimed at increasing intracellular specificity, disulfide reduction/activation switches are incorporated on iron-binding scaffolds resulting in intracellularly activated scavengers. Herein, this strategy is applied to several tridentate donor sets including thiosemicarbazones, aroylhydrazones and semicarbazones...
January 4, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29317104/the-role-of-ala134-in-controlling-substrate-binding-and-reactivity-in-ascorbate-peroxidase
#3
Daniel D Turner, Latesh Lad, Hanna Kwon, Jaswir Basran, Katherine H Carr, Peter C E Moody, Emma L Raven
Ascorbate peroxidase (APX) is a class I heme peroxidase. It has two sites for binding of substrates. One is close to the γ-heme edge and is used for oxidation of ascorbate; the other is at the δ-heme edge and is used for binding of aromatic substrates [Gumiero et al., (2010) Arch. Biochem. Biophys. 500, 13-20]. In this work, we have examined the structural factors that control binding at the δ-heme edge by replacement of Ala134 in APX with a proline residue that is more commonly found in other class II and III peroxidases...
December 29, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29306719/imaging-of-a-clickable-anticancer-iridium-catalyst
#4
Xiuxiu Wang, Mingli Zhu, Fei Gao, Wei Wei, Yong Qian, Hong-Ke Liu, Jing Zhao
Iridium-based anticancer reagents are receiving increasing attention for their high cytotoxicity. Herein, by activating CH bonds in the well-known antioxidant α-phenyl-N-tert-butylnitrone (PBN), we synthesized and characterized a series of new iridium complexes. Complex 1-AMP exhibited the best antiproliferation activity towards human ovarian cancer A2780 cells. The azide group in complex 1-AMP underwent the Cu(I)-catalysed azide-alkyne cycloaddition (CuAAC) reaction and the resulting fluorescent imaging in cells suggested it mainly accumulated in mitochondria...
December 29, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29307441/critical-analysis-of-reference-studies-on-the-toxicokinetics-of-aluminum-based-adjuvants
#5
REVIEW
Jean-Daniel Masson, Guillemette Crépeaux, François-Jérôme Authier, Christopher Exley, Romain K Gherardi
We reviewed the three toxicokinetic reference studies commonly used to suggest that aluminum (Al)-based adjuvants are innocuous. A single experimental study was carried out using isotopic 26Al (Flarend et al., Vaccine, 1997). This study used aluminum salts resembling those used in vaccines but ignored adjuvant uptake by cells that was not fully documented at the time. It was conducted over a short period of time (28days) and used only two rabbits per adjuvant. At the endpoint, Al elimination in the urine accounted for 6% for Al hydroxide and 22% for Al phosphate, both results being incompatible with rapid elimination of vaccine-derived Al in urine...
December 28, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29306116/incorporation-of-the-chemotherapy-medication-cisplatin-into-polyamide-membrane
#6
Érica A de Souza, Lucas A Rocha, Emerson H de Faria, Katia J Ciuffi, Eduardo J Nassar, Jorge V L Silva, Marcelo F Oliveira, Izaque A Maia
The search for more efficient and less aggressive cancer treatment methods has intensified over the last decades and has involved many scientific areas. To provide skin cancer patients with better quality of life, this work aims to incorporate chemotherapy into polyamide membranes, functionalized by the sol-gel methodology, for controlled drug release at the target tissue. A 200-micrometer-thick flexible polyamide membrane prepared by Additive Manufacture was activated and functionalized with the alkoxide 3-chloropropyltriethoxysilane, which was followed by incorporation of the antitumor agent cisplatin...
December 24, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29290391/amphoteric-phosphorous-v-phthalocyanines-as-proton-driven-switchable-fluorescers-toward-deep-tissue-bio-imaging
#7
Hiroaki Isago, Harumi Fujita, Tamotsu Sugimori
Spectral (optical absorption and emission) properties of three amphoteric phosphorous(V)-phthalocyanine derivatives, [P(Pc)(O)OH], where Pc=tetra(tert-butyl)phthalocyaninate (tbpc), tetrakis(2',6'-dimethylphenoxy)phthalocyaninate (tppc), and octakis(4'-tert-butylphenoxy)phthalocyaninate (obppc), have been investigated in ethanolic solutions. Spectral changes upon protonation/deprotonation (the reaction sites have been determined to be their axial ligands by magnetic circular dichroism study) are drastic and rapid...
December 23, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29288894/delivery-of-ru-%C3%AE-6-p-cymene-cl2-ph2p-ch2-3sph-%C3%AE%C2%BAp-using-unfunctionalized-and-mercapto-functionalized-sba-15-mesoporous-silica-preparation-characterization-and-in-vitro-study
#8
David Edeler, Sören Arlt, Vladana Petković, Gerd Ludwig, Dijana Drača, Danijela Maksimović-Ivanić, Sanja Mijatović, Goran N Kaluđerović
SBA-15 (Santa Barbara Amorphous 15) mesoporous silica and its functionalized form (with 3-mercaptopropyltriethoxysilane) SBA-15~SH were used as carriers for [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] complex, denoted as [Ru]. Prepared mesoporous silica nanomaterials were characterized by traditional methods. Materials without [Ru] complex did not show any cytotoxic activity against melanoma B16 and B16-F10 cell lines. On the contrary, materials containing [Ru] such as SBA-15|[Ru] and SBA-15~SH|[Ru], exhibited very high activity against tested tumor cell lines, moreover with similar inhibitory potential...
December 22, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29329026/the-interaction-of-pyridoxal-isonicotinoyl-hydrazone-pih-and-salicylaldehyde-isonicotinoyl-hydrazone-sih-with-iron
#9
Yu-Lin Chen, Xiaole Kong, Yuanyuan Xie, Robert C Hider
The interaction of pyridoxal isonicotinoyl hydrazone (PIH) and salicylaldehyde isonicotinoyl hydrazone (SIH), two important biologically active chelators, with iron has been investigated by spectrophotometric methods. High iron(III) affinity constants were determined for PIH, logβ2=37.0 and SIH, logβ2=37.6. The associated redox potentials of the iron complexes were determined using cyclic voltammetry at pH7.4 as +130mV (vs normal hydrogen electrode, NHE) for PIH and +136mV(vs NHE) for SIH. These redox potentials are much higher than those corresponding to iron chelators in clinical use, namely deferiprone, -620mV; desferasirox, -600mV and desferrioxamine, -468mV...
December 21, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29291491/triphenyltin-derivatives-of-sulfanylcarboxylic-esters
#10
José S Casas, María D Couce, Agustín Sánchez, Rafael Seoane, José Sordo, Antonio Perez-Estévez, Ezequiel Vázquez-López
The reaction of 3-(aryl)-2-sulfanylpropenoic acids [H2xspa; x: p=3-phenyl-, f=3-(2-furyl)-, t=3-(2-thienyl)-] with methanol or ethanol gave the corresponding methyl (Hxspme) or ethyl (Hxspee) esters. The reaction of these esters (HL) with triphenyltin(IV) hydroxide gave compounds of the type [SnPh3L], which were isolated and characterized as solids by elemental analysis, IR spectroscopy and mass spectrometry and in solution by multinuclear (1H, 13C and 119Sn) NMR spectroscopy. The structures of [SnPh3(pspme)], [SnPh3(fspme)] and [SnPh3(fspee)] were determined by X-ray diffractometry and the antimicrobial activity against E...
December 20, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29275221/structural-characterization-of-the-nitrogenase-molybdenum-iron-protein-with-the-substrate-acetylene-trapped-near-the-active-site
#11
Stephen M Keable, Jacopo Vertemara, Oleg A Zadvornyy, Brian J Eilers, Karamatullah Danyal, Andrew J Rasmussen, Luca De Gioia, Giuseppe Zampella, Lance C Seefeldt, John W Peters
The biological reduction of dinitrogen (N2) to ammonia is catalyzed by the complex metalloenzyme nitrogenase. Structures of the nitrogenase component proteins, Iron (Fe) protein and Molybdenum‑iron (MoFe) protein, and the stabilized complexes these component proteins, have been determined, providing a foundation for a number of fundamental aspects of the complicated catalytic mechanism. The reduction of dinitrogen to ammonia is a complex process that involves the binding of N2 followed by reduction with multiple electrons and protons...
December 13, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29247867/physicochemical-antioxidant-dna-cleaving-properties-and-antimicrobial-activity-of-fisetin-copper-chelates
#12
Elżbieta Łodyga-Chruscińska, Maria Pilo, Antonio Zucca, Eugenio Garribba, Elżbieta Klewicka, Magdalena Rowińska-Żyrek, Marzena Symonowicz, Longin Chrusciński, Vitalij T Cheshchevik
Fisetin (3,3',4',7-tetrahydroxyflavone) metal chelates are of interest as this plant polyphenol has revealed broad prospects for its use as natural medicine in the treatment of various diseases. Metal interactions may change or enhance fisetin biological properties so understanding fisetin metal chelation is important for its application not only in medicine but also as a food additive in nutritional supplements. This work was aimed to determine and characterize copper complexes formed in different pH range at applying various metal/ligand ratios...
December 11, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29247871/simple-and-mixed-complexes-of-copper-ii-with-8-hydroxyquinoline-derivatives-and-amino-acids-characterization-in-solution-and-potential-biological-implications
#13
Carmelo Sgarlata, Giuseppe Arena, Raffaele P Bonomo, Alessandro Giuffrida, Giovanni Tabbì
Copper(II) complexes with 8-hydroxyquinoline (8-HQ) and two 8-HQ derivatives, namely clioquinol (CQ) and 5,7-dichloro-2-[(dimethylamino)methyl]quinolin-8-ol (PBT2), were investigated in organic and, where feasible, in aqueous solutions. This class of compounds is of particular interest in neurological disorders since they may act as metal-protein attenuating compounds and may help redistributing metal ions and restoring intracellular metal reserves, which are often perturbed in neurological patients. Several techniques, like potentiometry, UV-Vis absorption, electron paramagnetic resonance (EPR), cyclic voltammetry and electrospray ionisation-mass spectrometry (ESI-MS), were used to obtain information on both the formation of copper(II) complexes in solution as well as on the structure of their species...
December 8, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29247870/synthesis-and-evaluation-of-the-antibiotic-and-adjuvant-antibiotic-potential-of-organotin-iv-derivatives
#14
Ana Soraya Lima Barbosa, Jéssica de Siqueira Guedes, Douglas Rozendo da Silva, Simoni Margareti Plentz Meneghetti, Mario Roberto Meneghetti, Amanda Evelyn da Silva, Morgana Vital de Araujo, Magna Suzana Alexandre-Moreira, Thiago Mendonça de Aquino, José Pinto de Siqueira Junior, Rodrigo Santos Aquino de Araújo, Ryldene Marques Duarte da Cruz, Francisco Jaime Bezerra Mendonça-Junior
A series of organotin(IV) derivatives was investigated in vitro for their antibiotic and adjuvant antibiotic properties (efflux pump inhibitors) against Staphylococcus aureus strains that overexpress efflux pump proteins for norfloxacin (SA-1199B), erythromycin (RN-4220) and tetracycline (IS-58). Most organotin(IV) compounds showed significant antibacterial activity with small Minimum Inhibitory Concentration (MIC) values, some of which were close to 1.0μg/mL (3.1μM), but this feature was also associated with substantial cytotoxicity...
December 8, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29247869/revisiting-the-thiosemicarbazonecopper-ii-reaction-with-glutathione-activity-against-colorectal-carcinoma-cell-lines
#15
Javier García-Tojal, Rubén Gil-García, Víctor Ivo Fouz, Gotzon Madariaga, Luis Lezama, María S Galletero, Joaquín Borrás, Friederike I Nollmann, Carlos García-Girón, Raquel Alcaraz, Mónica Cavia-Saiz, Pilar Muñiz, Òscar Palacios, Katia G Samper, Teófilo Rojo
Thiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to the potential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes rests on their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the [Cu(PTSC)(ONO2)]n compound (1) (HPTSC=pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopic and magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu(PTSC*)(ONO2)}2] derivative (2, HPTSC*=pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show the absence of peaks related with TSC-Cu-GSH species...
December 8, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29232638/engineering-a-self-sufficient-mycobacterium-tuberculosis-cyp130-by-gene-fusion-with-the-reductase-domain-of-cyp102a1-from-bacillus-megaterium
#16
Sandra Ortega Ugalde, Rosa A Luirink, Daan P Geerke, Nico P E Vermeulen, Wilbert Bitter, Jan N M Commandeur
CYP130 belongs to the subset of cytochrome P450s from Mycobacterium tuberculosis (Mtb) that have been structurally characterized. Despite several efforts for its functional characterization, CYP130 is still considered an orphan enzyme for which no endogenous or exogenous substrate has been identified. In addition, functional redox-partners for CYP130 have not been clearly established yet, hampering the elucidation of its physiological role. In the present study, a catalytically active fusion protein involving CYP130 and the NADPH reductase-domain of CYP102A1 from Bacillus megaterium was created...
December 7, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29232637/copper-ii-complexes-based-on-tripodal-pyrazolyl-amines-synthesis-structure-magnetic-properties-and-anticancer-activity
#17
Salah S Massoud, Febee R Louka, Gerard T Ducharme, Roland C Fischer, Franz A Mautner, Ján Vančo, Radovan Herchel, Zdeněk Dvořák, Zdeněk Trávníček
The Cu(II) complexes [Cu(bpdmpz)Cl]ClO4 (1), [Cu(bdmpzp)Cl]ClO4 (2-ClO4), [Cu(bdmpzp)Cl]PF6 (2-PF6) and [Cu(tdmpza)Cl]ClO4 (3), bpdmpzp=[bis[((2-pyridylmethyl)-di(3,5-dimethyl-1H-pyrazolyl)methyl)]amine, bdmpzp=[bis((di(3,5-dimethyl-1H-pyrazolyl)methyl)-(2-pyridylmethyl)]amine and tdmpza=tris[di(3,5-dimethyl-1H-pyrazolyl)-methyl)]amine were synthesized and characterized by elemental analysis, magnetic and conductivity measurements, electrospray-ionization mass spectrometry, infrared and electronic spectroscopy, and X-ray crystallography...
December 5, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29223826/modulation-effect-of-double-strand-dna-on-the-self-assembly-of-n-terminal-domain-of-euplotes-octocarinatus-centrin
#18
Wenlong Zhang, Enxian Shi, Yaqin Zhao, Binsheng Yang
Centrin is a member of the EF-hand super family of calcium-binding proteins, which can behave as a part of damage detector initiated the initiation of nucleotide excision repair (NER). Its self-assembly plays a causative role in fiber contraction associated with the cell division cycle and ciliogenesis. To explore the possible role of DNA in the process of centrin self-assembly, the aggregation properties of N-terminal domain of Euplotes octocarinatus centrin (N-EoCen) in the presence of DNA with or without metal ions are investigated...
December 5, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29227923/in-vitro-leishmanicidal-and-trypanocidal-evaluation-and-magnetic-properties-of-7-amino-1-2-4-triazolo-1-5-a-pyrimidine-cu-ii-complexes
#19
J M Méndez-Arriaga, I Oyarzabal, G Escolano, A Rodríguez-Diéguez, M Sánchez-Moreno, J M Salas
Two triazolopyrimidine complexes have been obtained from reaction between 7-amino-1,2,4-triazolo[1,5-a]pyrimidine (7atp) and Cu (II) salts. Crystal structures of [Cu2(μ-7atp)4Cl2]Cl2·4H2O (1) and [Cu2(μ-7atp)4(H2O)2](NO3)4·H2O (2) have been studied by X-ray diffraction methods and characterized by spectroscopic and thermal analysis. Magnetic studies of these dinuclear complexes have revealed the existence of moderate antiferromagnetic interactions between the copper ions, with J values of -91.2 and -96...
December 2, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29223825/theranostic-liposomes-as-a-bimodal-carrier-for-magnetic-resonance-imaging-contrast-agent-and-photosensitizer
#20
Paulina Skupin-Mrugalska, Lukasz Sobotta, Alicja Warowicka, Beata Wereszczynska, Tomasz Zalewski, Piotr Gierlich, Marcin Jarek, Grzegorz Nowaczyk, Marek Kempka, Jacek Gapinski, Stefan Jurga, Jadwiga Mielcarek
The present study is focused on the development of liposomes bearing gadolinium chelate (GdLip) providing two functionalities for magnetic resonance imaging (MRI) and photodynamic therapy of cancer. A lipid derivative of gadolinium(III) diethylenetriamine pentaacetic acid salt (GdDTPA1) was inserted in the liposomal membrane and served as MRI contrast agent whereas a zinc phthalocyanine (ZnPc) was used as a model photosensitizer. In addition to conventional liposomes, pegylated lipids were used for the preparation of "stealth" liposomes...
December 2, 2017: Journal of Inorganic Biochemistry
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