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Journal of Inorganic Biochemistry

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https://www.readbyqxmd.com/read/28214429/interplay-between-autophagy-and-apoptosis-in-selenium-deficient-cardiomyocytes-in-chicken
#1
Jie Yang, Yuan Zhang, Sattar Hamid, Jingzeng Cai, Qi Liu, Hao Li, Rihong Zhao, Hong Wang, Shiwen Xu, Ziwei Zhang
Dietary selenium (Se) deficiency can cause heart dysfunction, however the exact mechanism remains unclear. To understand this mechanism, 180day-old chicks, divided into two groups, C (control group) and L (low Se group), were fed with either a Se-sufficient (0.23mg/kg) or Se-deficient (0.033mg/kg) diets for 25days, respectively. Heart tissues and blood samples were collected. In L group, the activities of serum creatine kinase (CK) and creatine kinase-myoglobin (CK-MB) increased and typical ultrastructural apoptotic features were observed...
February 10, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28212901/the-dissociation-of-the-hsp60-pro-caspase-3-complex-by-bis-pyridyl-oxadiazole-copper-complex-cubipyoxa-leads-to-cell-death-in-nci-h292-cancer-cells
#2
Celeste Caruso Bavisotto, Dragana Nikolic, Antonella Marino Gammazza, Rosario Barone, Filippa Lo Cascio, Emanuele Mocciaro, Giovanni Zummo, Everly Conway de Macario, Alberto Jl Macario, Francesco Cappello, Valentina Giacalone, Andrea Pace, Giampaolo Barone, Antonio Palumbo Piccionello, Claudia Campanella
Cell survival and proliferation are central to carcinogenesis, involving various mechanisms among which those that impede apoptosis are important. In this, the role of the molecular chaperone Hsp60 is unclear since it has been reported that it can be both, pro- or anti-apoptotic. A solution to this riddle is crucial to the development of anti-cancer therapies targeting Hsp60. We addressed this question using a tumor cell line, NCI-H292, and [Cu(3,5-bis(2'-pyridyl)-1,2,4-oxadiazole)2(H2O)2](ClO4)2, CubipyOXA, a copper-containing compound with cytotoxic properties...
February 10, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28189031/water-soluble-metalloporphyrinates-with-excellent-photo-induced-anticancer-activity-resulting-from-high-tumor-accumulation
#3
Xiaojun Hu, Kazuma Ogawa, Tatsuto Kiwada, Akira Odani
To develop a water-soluble and tumor-targeted photosensitizer for photodynamic therapy (PDT), a porphyrin framework containing the metal ion gallium(III) was combined with platinum(II)-based groups to produce two new pentacationic metalloporphyrinates, Ga-4cisPtTPyP (5,10,15,20-tetrakis{cis-diammine-chloro-platinum(II)}(4-pyridyl)-porphyrinato gallium(III) hydroxide tetranitrate) and Ga-4transPtTPyP (5,10,15,20-tetrakis{trans-diammine-chloro-platinum(II)} (4-pyridyl)-porphyrinato gallium(III) hydroxide tetranitrate)...
February 4, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28160625/probing-nitrite-coordination-in-horseradish-peroxidase-by-resonance-raman-spectroscopy-detection-of-two-binding-sites
#4
Androulla Ioannou, Eftychia Pinakoulaki
Nitrite is a powerful oxidant that affects the activity of peroxidases towards various substrates and leads to heme macrocycle modifications in members of the peroxidase family, such as the horseradish peroxidase (HRP). We have applied resonance Raman spectroscopy to investigate the structural properties of the species formed in the reaction of NO2(-) with the ferric form of HRP. Our data demonstrate that the heme nitrovinyl group is partially formed at near neutral pH, without coordination of NO2(-) to the heme Fe...
January 25, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28161681/the-met80ala-and-tyr67his-met80ala-mutants-of-human-cytochrome-c-shed-light-on-the-reciprocal-role-of-met80-and-tyr67-in-regulating-ligand-access-into-the-heme-pocket
#5
Chiara Ciaccio, Lorenzo Tognaccini, Theo Battista, Manuela Cervelli, Barry D Howes, Roberto Santucci, Massimo Coletta, Paolo Mariottini, Giulietta Smulevich, Laura Fiorucci
The spectroscopic and functional properties of the single Met80Ala and double Tyr67His/Met80Ala mutants of human cytochrome c have been investigated in their ferric and ferrous forms, and in the presence of different ligands, in order to clarify the reciprocal effect of these two residues in regulating the access of exogenous molecules into the heme pocket. In the ferric state, both mutants display an aquo high spin and a low spin species. The latter corresponds to an OH(-) ligand in Met80Ala but to a His in the double mutant...
January 24, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28142080/new-copper-i-and-heteronuclear-copper-i-ruthenium-ii-complexes-synthesis-structural-characterization-and-cytotoxicity
#6
João Lopes, David Alves, Tânia S Morais, Paulo J Costa, M Fátima M Piedade, Fernanda Marques, Maria J Villa de Brito, M Helena Garcia
A new family of copper(I) complexes of general formula [Cu(dppe)(NN)](+) have been synthesized and fully characterized, with dppe=1.2-bis(diphenylphosphino)ethane and NN representing several bidentate heteroaromatic ligands: 2,2'-bipy=2.2'-bipyridine (1), Me2bpy=4.4'-dimethyl-2,2'-bipyridine (2), dpytz=3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine (3), dpp=2.3-bis(2-pyridyl)pyrazine (4), and the metallaligand [Ru(η(5)-C5H5)(PPh3)(dpp)](+) (5), yielding the bimetallic copper(I)-ruthenium(II) complex [Cu(dppe)(μ-dpp)Ru(η(5)-C5H5)(PPh3)](2+) (6)...
January 23, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28167404/comparison-of-extracellular-cys-trp-motif-between-schizosaccharomyces-pombe-ctr4-and-ctr5
#7
Mariko Okada, Takashi Miura, Takakazu Nakabayashi
The reduction and binding of copper ions to the Cys/Trp motif, which is characterized by two cysteines and two tryptophans, in the extracellular N-terminal domain of the copper transporter (Ctr) protein of fungi are investigated using the model peptides of Ctr4 and Ctr5 from Schizosaccharomyces pombe. The Cys/Trp motif of Ctr5 can reduce Cu(II) and ligate Cu(I), which is the same as that of Ctr4 previously reported. Titration of Cu(II) and Cu(I) ions indicates that both the Cys/Trp motifs of Ctr4 and Ctr5 reduce two Cu(II) and bind two Cu(I) per one peptide...
January 22, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28131879/heterologous-expression-of-halomonas-halodenitrificans-nitric-oxide-reductase-and-its-n-terminally-truncated-norc-subunit-in-escherichia-coli
#8
Nobuhiko Sakurai, Kunishige Kataoka, Noriko Sugaya, Takaki Shimodaira, Mie Iwamoto, Munehiro Shoda, Hajime Horiuchi, Miyuki Kiyono, Yasuke Ohta, Bambang Triwiyono, Daisuke Seo, Takeshi Sakurai
Halomonas halodenitrificans nitric oxide reductase (NOR) is the membrane-bound heterodimer complex of NorC, which contains a low-spin heme c center, and NorB, which contains a low-spin heme b center, a high-spin heme b3 center, and a non-heme FeB center. The soluble domain of NorC, NorC* (ΔMet1-Val37) was heterologously expressed in Escherichia coli using expression plasmids harboring the truncated norC gene deleted of its 84 5'-terminal nucleotides. Analogous scission of the N-terminal helix as the membrane anchor took place when the whole norC gene was used...
January 21, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28095346/crystal-structure-cytotoxicity-and-action-mechanism-of-zn-ii-mn-ii-complexes-with-isoquinoline-ligands
#9
Feng-Yang Wang, Qian-Yu Xi, Ke-Bin Huang, Xiao-Ming Tang, Zhen-Feng Chen, Yan-Cheng Liu, Hong Liang
Four μ2-Cl bridged dinuclear metal complexes with isoquinoline ligands, (MPDQ)2Zn2Cl4 (1) (MPDQ=4.5-methylenedioxy-1-pyridinedihydroisoquinoline), (PYP)2Zn2Cl4 (2) (PYP=5-pyridin-2-yl-[1,3]dioxolo[4,5-g]isoquinoline), (MPDQ)2Mn2Cl4 (3),and (PYP)2Mn2Cl4 (4) were synthesized and characterized. All complexes exhibited strong proliferation inhibition activity against various cancer cells. The underlying molecular mechanisms through which they caused the cancer cell death were also elucidated. Induction of apoptosis in MGC-803 cells by complex 2 was evidenced by annexin V(+)/PI(-) detection and DiD/DAPI staining assay...
January 6, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28131001/challenges-encountered-during-development-of-mn-porphyrin-based-potent-redox-active-drug-and-superoxide-dismutase-mimic-mntnbuoe-2-pyp-5-and-its-alkoxyalkyl-analogues
#10
Zrinka Rajic, Artak Tovmasyan, Otávio L de Santana, Isabelle N Peixoto, Ivan Spasojevic, Silmar A do Monte, Elizete Ventura, Júlio S Rebouças, Ines Batinic-Haberle
We disclose here the studies that preceded and guided the preparation of the metal-based, redox-active therapeutic Mn(III) meso-tetrakis(N-n-butoxyethylpyridyl)porphyrin, MnTnBuOE-2-PyP(5+) (BMX-001), which is currently in Phase I/II Clinical Trials at Duke University (USA) as a radioprotector of normal tissues in cancer patients. N-substituted pyridylporphyrins are ligands for Mn(III) complexes that are among the most potent superoxide dismutase mimics thus far synthesized. To advance their design, thereby improving their physical and chemical properties and bioavailability/toxicity profiles, we undertook a systematic study on placing oxygen atoms into N-alkylpyridyl chains via alkoxyalkylation reaction...
January 5, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28104568/new-insights-into-the-reaction-capabilities-of-his-195-adjacent-to-the-active-site-of-nitrogenase
#11
Ian Dance
The active site of the enzyme nitrogenase is the FeMo-cofactor (FeMo-co), a C-centred Fe7MoS9 cluster, connected to the surrounding MoFe protein via ligands Cys(275) and His(442). Density functional calculations, involving 14 additional surrounding amino acids, focus on His(195) because its mutation causes important reactivity changes, including almost complete loss of ability to reduce N2 to NH3. The Nε side-chain of His(195) is capable of hydrogen bonding to S2B, bridging Fe2 and Fe6 of FeMo-co, believed to be the main reaction domain of nitrogenase...
January 5, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28104569/interaction-of-octahedral-ruthenium-ii-polypyridyl-complex-ru-bpy-2-pip-2-with-poly-u-%C3%A2-poly-a-poly-u-triplex-increasing-third-strand-stabilization-of-the-triplex-without-affecting-the-stability-of-the-duplex
#12
Zhiyuan Zhu, Mengna Peng, Jingwen Zhang, Lifeng Tan
Triple-helical RNA are of interest because of possible biological roles as well as the potential therapeutic uses of these structures, while the stability of triplexes is usually weaker than that of the Watson-Crick base pairing duplex strand due to the electrostatic repulsion between three polyanionic strands. Therefore, how to increase the stability of the specific sequences of triplexes are of importance. In this paper the binding of a Ru(II) complex, [Ru(bpy)2(PIP)](2+) (bpy=2.2'-bipyridine, PIP=2-phenyl-1H-imidazo[4,5-f]- [1,10]-phenanthroline), with poly(U)·poly(A)*poly(U) triplex has been investigated by spectrophotometry, spectrofluorometry, viscosimetry and circular dichroism...
January 4, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28088013/delineating-hierarchy-of-selenotranscriptome-expression-and-their-response-to-selenium-status-in-chicken-central-nervous-system
#13
Xiu-Qing Jiang, Chang-Yu Cao, Zhao-Yang Li, Wei Li, Cong Zhang, Jia Lin, Xue-Nan Li, Jing-Long Li
Selenium (Se) incorporated in selenoproteins as selenocysteine and supports various important cellular and organismal functions. We recently reported that chicken brain exhibited high priority for Se supply and retention under conditions of dietary Se deficiency and supernutrition Li et al. (2012) . However, the selenotranscriptome expressions and their response to Se status in chicken central nervous system (CNS) are unclear. To better understand the relationship of Se homeostasis and selenoproteins expression in chicken CNS, 1day-old HyLine White chickens were fed a low Se diet (Se-L, 0...
January 4, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28024186/synthesis-characterization-dna-interactions-and-antiproliferative-activity-on-glioblastoma-of-iminopyridine-platinum-ii-chelate-complexes
#14
Inmaculada Posadas, Carlos Alonso-Moreno, Iván Bravo, Fernando Carrillo-Hermosilla, Andrés Garzón, Noemí Villaseca, Isabel López-Solera, José Albaladejo, Valentín Ceña
A series of iminopyridine platinum chelate compounds has been prepared and characterized by NMR spectroscopy and single-crystal X-ray diffraction. The complexes were evaluated in C6 tumoral cells as an in vitro model for glioblastoma multiforme. The DNA-binding properties of these complexes were studied by UV-Vis absorption and fluorescence spectroscopy and Density Functional Theory calculations were performed in an effort to rationalize the observed properties at the molecular level. The most promising drug candidate displayed a similar potency in inducing cell death to the clinically used reference compound and showed significant inhibition of glioblastoma cell proliferation...
December 19, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28024187/synthesis-photophysical-properties-and-structures-of-organotin-schiff-bases-utilizing-aromatic-amino-acid-from-the-chiral-pool-and-evaluation-of-the-biological-perspective-of-a-triphenyltin-compound
#15
Tushar S Basu Baul, Pelesakuo Kehie, Andrew Duthie, Nikhil Guchhait, Nune Raviprakash, Raveendra B Mokhamatam, Sunil K Manna, Nerina Armata, Michelangelo Scopelliti, Ruimin Wang, Ulli Englert
Five new organotin(IV) complexes of compositions [Me2SnL(1)] (1), [Me2SnL(2)]n (2), [Me2SnL(3)] (3), [Ph3SnL(1)H]n (4) and [Ph3SnL(3)H] (5) (where L(1)=(2S)-2-((E)-((Z)-4-hydroxypent-3-en-2-ylidene)amino)-3-(1H-indol-3-yl)propanoate, L(2)=(2S)-(E)-2-((2-hydroxybenzylidene)amino)-3-(1H-indol-3-yl)propanoate and L(3)=(2S)-(E)-2-((1-(2-hydroxyphenyl)ethylidene)amino)-3-(1H-indol-3-yl)propanoate were synthesized and spectroscopically characterized. The crystal structures of 1-4 were determined. For the dimethyltin derivative 2, a polymeric chain structure was observed as a result of a long Sn∙∙∙O contact involving the exocyclic carbonyl oxygen-atom from the tridentate ligand of a neighboring Sn-complex unit...
December 16, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28013066/antileukemic-activity-of-an-arsenomolybdate-in-the-human-hl-60-and-u937-leukemia-cells
#16
Chunyan Li, Hongqian Cao, Jiaheng Sun, Rui Tian, Dongbei Li, Yanfei Qi, Wei Yang, Juan Li
The antileukemic activity, mechanisms and serum albumin interactions of an arsenomolybdate, K2Na[AsMo6O21(O2CCH2NH3)3]·6H2O (1), was evaluated in the human leukemia HL-60 and U937 cells. The results indicated that 1 could inhibit the proliferation of both leukemia cell lines in a dose-dependent manner with the 50% lethal concentration (IC50) value of 8.61μM for HL-60 and 14.50μM for U937 at 24h, compare to the positive controls, all-trans retinoic acid (ATRA) with IC50 value of 20.76μM and 14.85μM,and As2O3 with IC50 value of 6...
December 16, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28013065/an-unlikely-dna-cleaving-agent-a-photo-active-trinuclear-cu-ii-complex-based-on-hexaazatriphenylene
#17
Dominique E Williams, Christina M Fischer, Miki Kassai, Lourdes Gude, María-José Fernández, Antonio Lorente, Kathryn B Grant
This paper describes the synthesis of a trinuclear Cu(II) complex (4) containing a central 1,4,5,8,9,12-hexaazatriphenylene-hexacarboxylate (hat) core (3). Low, micromolar concentrations of the negatively charged parent ligand 3 and the neutral trinuclear complex 4 were found to photocleave negatively charged pUC19 plasmid DNA with high efficiency at neutral pH (350nm, 50min, 22°C). The interactions of complex 4 with double-helical DNA were studied in detail. Scavenger and colorimetric assays pointed to the formation of Cu(I), superoxide anion radicals, hydrogen peroxide, and hydroxyl radicals during photocleavage reactions...
December 15, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27997856/new-silver-complexes-with-bioactive-glycine-and-nicotinamide-molecules-characterization-dna-binding-antimicrobial-and-anticancer-evaluation
#18
Michaela Rendošová, Zuzana Vargová, Juraj Kuchár, Danica Sabolová, Štefan Levoča, Júlia Kudláčová, Helena Paulíková, Daniela Hudecová, Veronika Helebrandtová, Miroslav Almáši, Mária Vilková, Michal Dušek, Dáša Bobáľová
This study introduces a pair of newly synthesized silver complexes, [Ag2(HGly)2]n(NO3)2n (1) and [Ag(Nam)2]NO3·H2O (2) (Gly - glycine, Nam - nicotinamide), that were prepared and characterized by relevant methods in solid state (elemental, spectral, thermal and structural analysis) and their stability in solution was verified by (1)H NMR measurements. Moreover, suitable reaction conditions were observed by potentiometry depending on pH in case of binary system Ag-Gly. X-ray analysis confirmed argentophilic interactions in complex 1 with an Ag1-Ag2 distance of 2...
December 15, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28006663/studies-on-the-mechanism-of-action-of-antitumor-bis-aminophenolate-ruthenium-iii-complexes
#19
Orsolya Dömötör, Rodrigo F M de Almeida, Leonor Côrte-Real, Cristina P Matos, Fernanda Marques, António Matos, Carla Real, Tamás Kiss, Éva Anna Enyedy, M Helena Garcia, Ana Isabel Tomaz
Two recently published Ru(III) complexes bearing (N2O2) tetradentate bis(aminophenolate) ligands, formulated as [Ru(III)(salan)(PPh3)Cl] (salan is the tetradentate ligand 6,6'-(1S,2S)-cyclohexane-1,2-diylbis(azanediyl)bis(methylene)bis(3-methoxyphenol) in complex 1, or 2,2'-(1S,2S)-cyclohexane-1,2-diylbis(azanediyl)bis(methylene)bis(4-methoxyphenol) in complex 2; PPh3 is triphenylphosphane) and found very active against ovarian and breast adenocarcinoma human cells were studied to outline their antitumor mode of action...
December 14, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28110161/citrate-and-albumin-facilitate-transferrin-iron-loading-in-the-presence-of-phosphate
#20
Catalina Matias, Devin W Belnap, Michael T Smith, Michael G Stewart, Isaac F Torres, Andrew J Gross, Richard K Watt
Labile plasma iron (LPI) is redox active, exchangeable iron that catalyzes the formation of reactive oxygen species. Serum transferrin binds iron in a non-exchangeable form and delivers iron to cells. In several inflammatory diseases serum LPI increases but the reason LPI forms is unknown. This work evaluates possible pathways leading to LPI and examines potential mediators of apo transferrin iron loading to prevent LPI. Previously phosphate was shown to inhibit iron loading into apo transferrin by competitively binding free Fe(3+)...
December 11, 2016: Journal of Inorganic Biochemistry
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