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Journal of Inorganic Biochemistry

Xudong Shi, Langtao Shen
With the advent of positron emission tomography/magnetic resonance imaging (PET/MRI) scanner, PET/MRI dual-modal imaging will play more and more important role in the diagnosis of cancers and other diseases. Until now, there is no an approved PET/MRI dual-modal imaging probe. The goal of this work is to design and synthesize potential PET/MRI dual-modal imaging probe based on superparamagnetic manganese ferrite nanoparticles. We have developed superparamagnetic nanoparticles that have uniform size with 5 nm and can be further functionalized through surface coating with dopamine and polyethylene glycol derivatives, which provide functional groups for conjugating tumor-targeting biomolecules and bifunctional chelators...
July 6, 2018: Journal of Inorganic Biochemistry
Biswarup Jash, Jens Müller
A stable zinc(II)-mediated base pair was formed within a parallel-stranded DNA duplex comprising a GNA (glycol nucleic acid) functionalized nucleoside analog containing the artificial nucleobase 1H-imidazo[4,5-f][1,10]phenanthroline (P). The formation of the metal-mediated base pair was confirmed by UV and CD spectroscopic analyses. In the Zn(II)-mediated homo base pairs of the type P-Zn(II)-P, the metal ion adopts a [2 + 2] coordination environment. CD spectroscopic data suggest that the chiral metal complex is formed enantiospecifically, likely induced by the helical chirality of the surrounding DNA duplex...
July 5, 2018: Journal of Inorganic Biochemistry
Wenlong Zhang, Enxian Shi, Yaqin Zhao, Binsheng Yang
The xeroderma pigmentosum group C protein (XPC) and centrin2 are the primary initiators of global genome nucleotide excision repair (NER). Centrin, acts as a member of the EF-hand super family of calcium-binding proteins, playing roles in reconstitution of the vitro NER reaction. To understand the possible molecular and structural properties of the multiprotein process, the interactions of Euplotes octocarinatus centrin (EoCen), melittin, and DNA are described. EoCen shares a sequence identity of 66% with centrin2...
July 5, 2018: Journal of Inorganic Biochemistry
Júlia Scaff Moreira Dias, Henrique Vieira Reis Silva, Guilherme Álvaro Ferreira-Silva, Marisa Ionta, Charlane Cimini Corrêa, Fernando Almeida, Legna Colina-Vegas, Marília Imaculada Frazão Barbosa, Antonio Carlos Doriguetto
Herein, novel ruthenium(II) complexes containing 1-methylimidazole as a ligand were obtained with the following formulas: [RuCl(1Meim)(dppb)(bpy)]Cl (1), [RuCl(1Meim)(dppb)(4,4'-DMbpy)]Cl (2), [RuCl(1Meim)(dppb)(5,5'-DMbpy)]Cl (3) and [RuCl(1Meim)(dppb)(phen)]Cl (4) where, 1Meim = 1-methylimidazole, dppb = 1,4-Bis(diphenylphosphino)butane, bpy = 2,2'-bipyridine, 4,4'-DMbpy = 4,4'-dimethyl-2,2'-bipyridine, 5,5'-DMbpy = 5,5'-dimethyl-2,2'-bipyridine and phen = 1,10-phenanthroline. Additionally, crystal structures containing the cations of (1) and (3) were obtained when the counter ion was exchanged, leading to the formation of [RuCl(1Meim)(dppb)(bpy)]PF6 (5) and [RuCl(1Meim)(dppb)(5,5'-DMbpy)]PF6 methanol solvate (6) where PF6  = hexafluorophosphate, showing one 1-methylimidazole molecule coordinated through the imidazole nitrogen, as expected...
July 4, 2018: Journal of Inorganic Biochemistry
Maria A S Silva, Adolfo I B Romo, Dieric S Abreu, Marta S P Carepo, Luis Lemus, Miguel Jafelicci, Tércio F Paulo, Otaciro R Nascimento, Esteban Vargas, Juliano C Denardin, Izaura C N Diógenes
Magnetic nanoparticles have been extensively explored for the development of platforms for drug delivery and imaging probes. In this work, we have used a modular capping strategy to produce magnetic gold-coated Fe3 O4 (Fe3 O4 @Au) nanoparticles, which have been decorated with a copper (II) complex containing a thioether derivative of clip-phen (Fe3 O4 @Au@Cu), where the complex [Cu(2CP-Bz-SMe)]2+ has affinity to bind DNA and proven nuclease activity (2CP-Bz-SMe=1,3-bis((1,10-phenanthrolin-2-yl)oxy)-N-(4-(methylthio)benzylidene)propan-2-imine)...
June 30, 2018: Journal of Inorganic Biochemistry
Jiyong Hu, Shufang Chen, Ruina Mao, Chunli Liao, Hao Yang, Jin'an Zhao
To investigate the cytotoxicity and mechanism of action of multinuclear Cu complexes against tumor cell lines, two complexes, Cu6 (bpbib)4 Br8 (1) and Cu2 (bpbib)2 (BF4 )2 Cl2 (2) (bpbib = 1,4-bis((2-(pyrazin-2-yl)-1H-benzo[d]imidazol-1-yl)methyl)benzene) were synthesized and characterized. Both Cu complexes showed high selectivity toward cancer and not normal cells, and the SMMC7721 cell line showed most sensitivity toward both complexes. Complex 1 exhibited more potent cytotoxicity and enhanced cellular uptake, and therefore, was comprehensively investigated...
June 30, 2018: Journal of Inorganic Biochemistry
Tianqi Liu, Tianshu Yang, Zhe Xu, Siran Tan, Tingru Pan, Na Wan, Shu Li
Selenium (Se) is an important nutritional element in the diet. Apoptosis is one of the characteristic pathological changes in liver tissue resulting from Se deficiency. MicroRNA (miRNA) plays an important role in cell proliferation, differentiation, apoptosis and tumorigenesis. However, why apoptosis occurs during Se deficiency and how miRNA regulates hepatocyte apoptosis in broilers requires further study. We used a dual luciferase reporter assay system and quantitative real-time PCR (qPCR) to screen hepatocytes in Se-deficient broilers for the specificity of hepatocyte apoptosis miRNA and its target protein...
June 28, 2018: Journal of Inorganic Biochemistry
Soma Das, Kenia Parga, Indranil Chakraborty, Arthur D Tinoco, Yamixa Delgado, Paola M López, Lauren Fernández Vega, Yiannis Sanakis, Sukhen Ghosh, Jim Bankson, Jim Klostergaard, Ricardo González-Méndez, Raphael G Raptis
A water-soluble octanuclear cluster, [Fe8 ], was studied with regard to its properties as a potential contrast enhancing agent in magnetic resonance imaging (MRI) in magnetic fields of 1.3, 7.2 and 11.9 T and was shown to have transverse relaxivities r2  = 4.01, 10.09 and 15.83 mM s-1 , respectively. A related hydrophobic [Fe8 ] cluster conjugated with 5 kDa hyaluronic acid (HA) was characterized by 57 Fe-Mössbauer and MALDI-TOF mass spectroscopy, and was evaluated in aqueous solutions in vitro with regard to its contrast enhancing properties [r2  = 3...
June 24, 2018: Journal of Inorganic Biochemistry
Craig C McLauchlan, Heide A Murakami, Craig A Wallace, Debbie C Crans
Vanadium-dependent haloperoxidases are a class of enzymes that catalyze oxidation reactions with halides to form halogenated organic products and water. These enzymes include chloroperoxidase and bromoperoxidase, which have very different protein sequences and sizes, but regardless the coordination environment of the active sites is surprisingly constant. In this manuscript, the comparison of the coordination chemistry of V-containing-haloperoxidases of the trigonal bipyramidal geometry was done by data mining...
June 18, 2018: Journal of Inorganic Biochemistry
Michaela Rendošová, Zuzana Vargová, Danica Sabolová, Natália Imrichová, Daniela Hudecová, Róbert Gyepes, Boris Lakatoš, Katarína Elefantová
In the current study the ability of silver pyridine-2-sulfonate complex to exert multiple biological activities is compared with the pharmacological action of silver sulfadiazine (AgSD). Polymeric form of {[Ag(py-2-SO3 )]}n (AgPS) was synthesized and characterized by analytical techniques (IR, CHN, TG/DTA, MS) and its molecular formula was established. The crystal structure was determined by X-ray diffraction method and the polymeric complex crystallizes in the triclinic P-1 space group. The stability of Ag(I) complex was verified by 1 H and 13 C NMR measurements and the interaction with calf thymus DNA through UV-VIS and fluorescence quenching experiments was studied...
June 18, 2018: Journal of Inorganic Biochemistry
Urszula K Komarnicka, Sandra Kozieł, Radosław Starosta, Agnieszka Kyzioł
The main disadvantage of conventional anticancer chemotherapy is the inability to deliver the correct amount of drug directly to cancer. Those molecular delivering systems are very important to destroy cancer cells selectively. Herein we report synthesis of phosphine-peptide conjugate (Ph2 PCH2 -Sar-Gly-OH, PSG) derived from SarGly (sarcosine-glycine), which can be easily exchanged to other peptide carriers, its oxide (OPh2 PCH2 -Sar-Gly-OH, OPSG) and the first copper(I) complex ([CuI(dmp)(P(Ph)2 CH2 -Sar-Gly-OH)], 1-PSG, where dmp stands for 2,9-dimethyl-1,10-phenanthroline)...
June 18, 2018: Journal of Inorganic Biochemistry
Beatriz N Cunha, Legna Colina-Vegas, Ana M Plutín, Rafael G Silveira, João Honorato, Katia M Oliveira, Marcia R Cominetti, Antônio G Ferreira, Eduardo E Castellano, Alzir A Batista
In this study, Ru(II)-arene complexes with acylthiourea ligands of the type [Ru(η6 ‑p‑cymene)(PPh3 )(T)Cl]PF6 (1-5) and [Ru(η6 ‑p‑cymene)(PPh3 )(T)]PF6 (1a, 4a), where PPh3  = triphenylphosphine and T = N‑acyl‑N'(monosubstituted)thiourea, were synthesized and characterized, and their cytotoxic properties were also evaluated. 1a and 4a were obtained from the hydrolysis reaction of 1 and 4. All complexes showed unusual coordination modes for acylthiourea ligands, which are coordinated in a monodentate fashion (S) in 1-5, while they found to be bidentate (S,N), in 1a and 4a...
June 18, 2018: Journal of Inorganic Biochemistry
Min Wang, Xiaofang Fei, Shaowu Lv, Ye Sheng, Haifeng Zou, Yanhua Song, Fei Yan, Qianlong Zhu, Keyan Zheng
In this study, we designed and synthesized two novel fluorescent magnetic nanoparticles. Fe3 O4 @SiO2 -NH-GSH-CdTe (FSGC) (GSH = glutathione) nanoparticles were synthesized using amino-functionalized Fe3 O4 @SiO2 nanoparticles and GSH-stabilized CdTe quantum dots (CdTe QDs), while flexible Fe3 O4 @SiO2 -NH-GSH-CdTe-NH-NH2 (FSGCN) nanoparticles were synthesized using the FSGC precursor and 1,6-hexamethylenediamine. These two kinds of nanoprobes exhibited excellent magnetic and fluorescent properties. By comparing the fluorescence quenching effect of folic acid (FA) on FSGC and FSGCN, we found that the quenching effect of FA on FSGC was acute and the process was too fast to determine the FA content...
June 15, 2018: Journal of Inorganic Biochemistry
Christos T Chasapis
The role of metal ions in virus-host interactions is largely unknown. In the present computational study, the putative zinc, manganese, magnesium, and iron metalloproteomes of 226 different viruses were identified and then the human proteins interacting the viral metalloproteomes were retrieved through network-based bioinformatics. Protein features such as abundance, function and structurally disorder were classified according to the metal type bound to viral proteins. Likely perturbations of host cellular metal homeostasis by viral metal binders are also discussed...
June 15, 2018: Journal of Inorganic Biochemistry
Tsuneo Omura
Cytochrome P450 (P450) of eukaryotes and prokaryotes diversified remarkably during the long course of their evolution. Since the diversification of P450 was the consequence of the adaptation of various living organisms to diverse environmental changes, the catalytic activities and physiological functions of the P450s of different taxa can be significantly different. It is likely that many P450s with novel physiological functions will be found in future when we further identify and examine the P450s of various eukaryotes and prokaryotes...
June 7, 2018: Journal of Inorganic Biochemistry
Minh Quan Do, Evelynn Henry, Mallory Kato, Lionel Cheruzel
Cross-linked enzyme aggregate (CLEA) methodology has been applied to immobilize cytochrome P450 BM3 variants (F87A and 21B3) with peroxygenase activity. Several Ru(II)-diimine complexes were found to be suitable cross-linking agents, surpassing the traditional glutaraldehyde and dextran aldehyde. They offer modular numbers of aldehyde functionalities and a more rigid framework than their organic counterparts. The F87A CLEAs display significant activity loss compared to the protein in solution. Meanwhile, for the 21B3 CLEAs, high activity recovery (up to 95%) is obtained...
June 5, 2018: Journal of Inorganic Biochemistry
Garret Rochford, Zara Molphy, Niall Browne, Carla Surlis, Michael Devereux, Malachy McCann, Andrew Kellett, Orla Howe, Kevin Kavanagh
Herein we report the in-vivo characterisation and metabolic changes in Galleria mellonella larvae to a series of bis-chelate copper(II) phenanthroline-phenazine cationic complexes of [Cu(phen)2 ]2+ (Cu-Phen), [Cu(DPQ)(Phen)]2+ (Cu-DPQ-Phen) and [Cu(DPPZ)(Phen)]2+ (Cu-DPPZ-Phen) (where phen = 1,10-phenanthroline, DPQ = dipyrido[3,2-ƒ:2',3'-h]quinoxaline and DPPZ = dipyrido[3,2-a:2',3'-c]phenazine). Our aim was to investigate the influence of the systematic extension of the ligated phenazine ligand in the G...
June 1, 2018: Journal of Inorganic Biochemistry
Camila Fontes Neves da Silva, Bruna Possato, Lilian Pereira Franco, Loyanne Carla Barbosa Ramos, Sofia Nikolaou
Two novel triruthenium clusters, [Ru3 (μ3 -O)(μ-OOCCH3 )6 (NO)L2 ]PF6 (L = 4‑acetylpyridine, 1, or 4‑tert‑butylpyridine, 2) release NO. Their spectroscopic and electrochemical characterization confirmed their structure. These complexes efficiently deliver NO in solution under irradiation at λirrad  = 377 nm and/or through chemical reduction with ascorbic acid. Clusters 1 and 2 elicit vasodilation and, at concentrations of 10-5  M, can relax up to 100% of pre-contracted rat aorta. Complex 2 is more cytotoxic to murine melanoma B16F10 cells than complex 1: at 50 times lower concentration than complex 1, complex 2 decreases cell viability to 50% in the dark or under irradiation with visible light (λirrad  = 527 nm)...
May 30, 2018: Journal of Inorganic Biochemistry
Anna Irto, Paola Cardiano, Karam Chand, Rosalia Maria Cigala, Francesco Crea, Concetta De Stefano, Lurdes Gano, Silvio Sammartano, Maria Amélia Santos
This paper reports the results on the study of a set of synthesized bifunctional 3-hydroxy-4-pyridinones chelators as potential aluminium sequestering agents. They were N-functionalized with alkyl-amino, -carboxylic and -(amino-carboxylic) groups, envisaging the improvement of the Al3+ sequestering capacity, in comparison with the marketed chelating drug deferiprone. The main focus of this work was given to the assessment of their binding ability towards Al3+ , which was studied by potentiometric and UV-Vis spectrophotometric measurements carried out at T = 298...
May 30, 2018: Journal of Inorganic Biochemistry
André M N Silva, João T S Coimbra, Maria M Castro, Ângela Oliveira, Natércia F Brás, Pedro A Fernandes, Maria J Ramos, Maria Rangel
Understanding the effect of glycation on the function of transferrin, the systemic iron transporter, is fundamental to fully grasp the mechanisms leading to the loss of iron homeostasis observed in diabetes mellitus (DM). The spontaneous reaction with protein amino groups is one of the main causes of glucose toxicity, but the site specificity of this reaction is still poorly understood. Here in, an in vitro approach was used to study human holo-transferrin glycation in detail. Lysine residues 103, 312 and 380 proved to be the most reactive sites, and overall glycation specificity was found to be remarkably different from that described for apo-transferrin...
May 26, 2018: Journal of Inorganic Biochemistry
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