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Journal of Inorganic Biochemistry

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https://www.readbyqxmd.com/read/30218890/zeise-s-salt-as-powerful-platinating-agent-for-proteins-investigated-by-top-down-mass-spectrometry
#1
Monika Cziferszky, Ronald Gust
Metallodrugs have become an integral part of modern medicinal chemistry with platinum drugs as anti-cancer agents being well-known examples. The historically interesting compound Zeise's salt, potassium trichlorido(ethene)platinate(II) has scarcely been investigated in this context yet. This study is geared towards shedding light on the biological reactivity of this platinum complex. Mass Spectrometry tools were used to obtain a deeper understanding of its interactions with biomolecules on the molecular level...
September 8, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30218889/study-on-the-detoxification-mechanisms-to-5-10-15-20-tetrakis-4-sulfonatophenyl-porphyrinato-iron-iii-chloride-fetpps-an-efficient-pro-oxidant-of-heme-water-soluble-analogue
#2
Pengfei Zhang, Lu Ma, Zhen Yang, Hailing Li, Zhonghong Gao
5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato iron(III) chloride (FeTPPS) is a water-soluble analog of heme and widely employed as peroxynitrite scavenger in vivo. However, previous studies have showed that like heme, FeTPPS could also act as an effective pro-oxidant towards appreciable substrates in vitro in the presence of oxidant. The reason that FeTPPS did not show any pro-oxidative damage in previous studies when it was used as peroxynitrite decomposition catalyst in vivo, has not been studied. Herein, the effects of two main detoxification mechanisms of heme, i...
September 6, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30218888/rigid-dinuclear-ruthenium-arene-complexes-showing-strong-dna-interactions
#3
Qi Wu, Liu-Yi Liu, Shunli Li, Fang-Xin Wang, Ji Li, Yong Qian, Zhi Su, Zong-Wan Mao, Peter J Sadler, Hong-Ke Liu
Six novel dinuclear Ru(II)-arene complexes [Ru2 (η6 -p-cymene)2 (1,3-bib)2 Cl2 ]×2 ·Solvent (X = Cl- (1), I- (2), NO3 - (3), BF4 - (4), PF6 - (5), CF3 SO3 - (6); 1,3-bib = 1,3-di(1H-imidazol-1-yl) benzene) were synthesized and fully characterized by FT-IR, 1 H NMR, ESI-MS, Elemental Analysis (EA) and Powder X-ray Diffraction (PXRD). Single crystal X-ray diffractions studies showed that 3 and 4 have rigid bowl-like structures, where one counter-anion (NO3 - for 3 and BF4 - for 4) was trapped inside the cavity to balance the charge, respectively...
August 24, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30149123/regulation-of-heteronuclear-pt-ru-complexes-on-the-fibril-formation-and-cytotoxicity-of-human-islet-amyloid-polypeptide
#4
Gehui Gong, Weihong Du, Jufei Xu, Xiangyi Huang, Guowei Yin
The deposition of human islet amyloid polypeptide (hIAPP) is considered as a causative factor of type 2 diabetes mellitus (T2DM). Developing effective inhibitors against the fibril formation of hIAPP is a potential way to treat T2DM. Recent studies indicate that various metal complexes including homo-binuclear Ru complexes can inhibit hIAPP aggregation. Hetero-multinuclear PtRu metal complexes exhibit multiple bioactivities, but their roles in reversing amyloidosis remain unclear. In this work, we synthesized and identified a new hetero-binuclear PtRu metal complex Na{[RuCl4 (DMSO-S)](bpy)[Pt(DMSO-S)Cl2 ]} (bpy: 4,4'-bipyridyl)...
August 18, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30149122/structural-features-of-uranium-protein-complexes
#5
Oliviero Carugo
Uranium toxicity depends on its chemical properties rather than on its radioactivity and involves its interaction with macromolecules. Here, a systematic survey of the structural features of the uranyl sites observed in protein crystal structures deposited in the Protein Data Bank is reported. Beside the two uranyl oxygens, which occupy the axial positions, uranium tends to be coordinated by five other oxygen atoms, which occupy the equatorial vertices of a pentagonal bipyramid. Even if one or more of these equatorial positions are sometime empty, they can be occupied only by oxygen atoms that belong to the carboxylate groups of Glu and Asp side-chains, usually acting as monodentate ligands, to water molecules, or to acetate anions...
August 18, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30153544/bodipy-based-ru-ii-and-ir-iii-organometallic-complexes-of-avobenzone-a-sunscreen-material-potent-anticancer-agents
#6
Gajendra Gupta, Shirisha Cherukommu, Gunda Srinivas, Seon Woong Lee, Sung Hwan Mun, Jaehoon Jung, Narayana Nagesh, Chang Yeon Lee
The use of organic compounds with known medicinal properties in the synthesis of metal-based complexes is an important alternative to improve the biological activity of metal-based drugs. The reaction of [M(arene)Cl2 ]2 (M = Ru, arene = p-cymene and M = Ir, arene = pentamethylcyclopentadienyl, cp*) with avobenzone (1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, AVBH) and KOH in methanol leads to the formation of the neutral complexes [Ru(p-cymene)(AVB)Cl] 1 and [Ir(cp*)(AVB)Cl] 2 (cp* = pentamethylcyclopentadienyl)...
August 16, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30125832/search-for-cytotoxic-compounds-against-ovarian-cancer-cells-synthesis-characterization-and-assessment-of-the-activity-of-new-camphor-carboxylate-and-camphor-carboxamide-silver-complexes
#7
M Fernanda N N Carvalho, Ana M Botelho do Rego, Adelino M Galvão, Rudolf Herrmann, Fernanda Marques
Five silver camphor complexes of formulae [Ag2 (L)(L')2 ] (1,3,5) or [Ag(L)2 (L')] (2,4) were synthesized from silver nitrate and the suitable camphor carboxylate (L1 ) or camphor carboxamides (L3 , L4 ). The complexes were characterized by elemental analysis and spectroscopic techniques (NMR, FTIR, XPS). Computational calculations support coordination of the carboxylate group to silver, in the case of complex 2 and combined mixed keto/carboxylate in the case of complex 1. The stability of the complexes highly relies on the tetrahedral geometry of the lithium ion that binds to four oxygen atoms of the camphor carboxylate ligands...
August 16, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30121399/evidences-for-zinc-ii-and-copper-ii-ion-interactions-with-mycobacterium-leprae-hsp18-effect-on-its-structure-and-chaperone-function
#8
Sandip Kumar Nandi, Ayon Chakraborty, Alok Kumar Panda, Rajiv Kumar Kar, Anirban Bhunia, Ashis Biswas
Mycobacterium leprae uptakes various bivalent metal ions via different transporters in host species. Uptake of Cu2+ and Zn2+ are essential for generation of superoxide dismutases and catalases, which provide defense against reactive oxygen species mediated death of this pathogen in macrophages. Furthermore, it has also been noticed that levels of different bivalent metal ions (Ca2+ , Mg2+ , Cu2+ and Zn2+ ) in blood serum are altered in leprotic patients. Mycobacterium leprae HSP18 is an immunodominant antigen which helps in growth and survival of Mycobacterium leprae in host species...
August 10, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30121398/thermodynamic-stability-and-structure-in-aqueous-solution-of-the-cu-pta-4-complex-pta-aminophosphine%C3%A2-1-3-5%C3%A2-triaza%C3%A2-7%C3%A2-phosphaadamantane
#9
Martina Quaretti, Marina Porchia, Francesco Tisato, Angela Trapananti, Giuliana Aquilanti, Marko Damjanović, Luciano Marchiò, Marco Giorgetti, Matteo Tegoni
The chemistry of copper(I) with water-soluble phosphines is an emergent area of study which has the objective of finding ligands that stabilize copper in its lower oxidation state. Cu(I) has been found relevant in the mechanism of copper transports into cells, and the accessibility of this oxidation state has implications in oxidative stress processes. For these reasons the possibility to deal with stable, water soluble copper(I) is an attractive approach for devising new biologically relevant metal-based drugs and chelating agents...
August 10, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30119016/oxidant-generation-resulting-from-the-interaction-of-copper-with-menadione-vitamin-k3-a-model-for-metal-mediated-oxidant-generation-in-living-systems
#10
Guowei Xing, Christopher J Miller, A Ninh Pham, Adele M Jones, T David Waite
The oxidation of hydroquinones is of interest both due to the generation of reactive oxygen species (ROS) and to the implications to trace metal redox state. Menadione (MNQ), a typical toxicant quinone used extensively for studying the mechanisms underlying oxidative stress, is known to be an effective source of exogenous ROS. In this study, the kinetics and mechanism of the oxidation of menadiol (MNH2 Q, the reduced form of MNQ) in the absence and presence of copper (Cu) over the pH range 6.0-7.5 was examined...
August 8, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30170307/a-new-approach-to-understanding-structure-function-relationships-in-cytochromes-p450-by-targeting-terpene-metabolism-in-the-wild
#11
Nathan R Wong, Xinyue Liu, Hannah Lloyd, Allison M Colthart, Alexander E Ferrazzoli, Deani L Cooper, Yihao Zhuang, Phillix Esquea, Jeffrey Futcher, Theodore M Pochapsky, Jeffrey M Matthews, Thomas C Pochapsky
A strategy for elucidating sequence determinants of function in the class of cytochrome P450 (CYP) enzymes that catalyze the first steps of terpene metabolism in wild microbiomes is described. Wild organisms that can use camphor, terpineol, pinene and limonene were isolated from soils rich in coniferous waste. Cell free extracts and growth beers were analyzed by gas chromatography/mass spectrometry to identify primary oxidative metabolites. For one organism, Pseudomonas nitroreducens TPJM, a cytochrome P450 (CYP108B1) isolated from cell free extracts was demonstrated to catalyze the oxidation of α-terpineol in assays combining the native ferredoxin and putidaredoxin reductase, and the resulting oxidation products identified by gas chromatography/mass spectrometry...
August 6, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30119015/ldl-dinitrosyl-iron-complex-acts-as-an-iron-donor-in-mouse-macrophages
#12
Hanna Lewandowska, Tomasz M Stępkowski, Sylwia Męczyńska-Wielgosz, Katarzyna Sikorska, Jarosław Sadło, Jakub Dudek, Marcin Kruszewski
[Fe(NO)2 ] - modified nanoparticles of low-density protein (DNICLDL) can serve as conveyors of iron in the form of stable complexes with ApoB100 protein. As reported recently, in human hepatoma cells DNICLDL significantly increased the total iron content, while showing low toxicity. In the present work, we focused on the effects of internalization of DNIC-modified lipoproteins in macrophages, with special regards to cytotoxicity. DNICLDL was administered to a model macrophage cell line, RAW 264.7. Administration of DNICLDL considerably increased total iron content...
August 4, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30098472/influence-of-inter-domain-dynamics-and-surrounding-environment-flexibility-on-the-direct-electrochemistry-and-electrocatalysis-of-self-sufficient-cytochrome-p450-3a4-bmr-chimeras
#13
Silvia Castrignanò, Giovanna Di Nardo, Sheila J Sadeghi, Gianfranco Gilardi
The linker region of multi-domain enzymes has a very important role for the interconnection of different enzyme modules and for the efficiency of catalytic activity. This is particularly evident for artificial chimeric systems. We characterised an artificial self-sufficient enzyme developed by genetic fusion of the catalytic domain of cytochrome P450 3A4 and reductase domain of Bacillus megaterium BM3 (BMR). Here we report the direct electrochemistry of 3A4-BMR chimeras immobilised on glassy carbon electrodes and we investigated the effect of inter-domain loop length and immobilising environment flexibility on both redox properties and electrocatalysis...
August 4, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30096535/copper-or-and-arsenic-induces-autophagy-by-oxidative-stress-related-pi3k-akt-mtor-pathways-and-cascaded-mitochondrial-fission-in-chicken-skeletal-muscle
#14
Yu Wang, Hongjing Zhao, Yizhi Shao, Juanjuan Liu, Jinglun Li, Liyang Luo, Mingwei Xing
Autophagy is an ubiquitin proteasome system for degradation of intracellular damaged proteins and organelles. Both as environmental pollutants, flourishing data show arsenic (As) and copper (Cu) as robust oxidative stress inducers. Whether this kind of damage correlates with autophagy through the phosphoinositide-3-kinase/protein kinase b/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway still remains elusive. A 12-week exposures of Cu or/and As to chicken time-dependently displayed significant element residue in the pectoralis...
August 4, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30121400/vanadyl-complexes-discriminate-between-neuroblastoma-cells-and-primary-neurons-by-inducing-cell-specific-apoptotic-pathways
#15
Yue Zhang, Lichao Wang, Kewu Zeng, Kui Wang, Xiaoda Yang
Vanadium compounds have arisen as potential therapeutic agent for the treatment of cancers over the past decades. A few studies suggested that vanadyl complexes may discriminate between the cancerous and the normal cells. Here, we reported the investigation on the pro-apoptotic effect and the underlying mechanism of bis(acetylacetonato) oxovanadium(IV) ([VO(acac)2 ]) on SH-SY5Y neuroblastoma cells in comparison with that of mouse primary cortex neurons. The experimental results revealed that [VO(acac)2 ] showed about 10-fold higher cytotoxicity (IC50 ~16 μM) on the neuroblastoma cells than on normal neurons (IC50 ~250 μM)...
August 3, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30119014/structural-and-catalytic-properties-of-the-peroxygenase-p450-enzyme-cyp152k6-from-bacillus-methanolicus
#16
Hazel M Girvan, Harshwardhan Poddar, Kirsty J McLean, David R Nelson, Katherine A Hollywood, Colin W Levy, David Leys, Andrew W Munro
The CYP152 family of cytochrome P450 enzymes (P450s or CYPs) are bacterial peroxygenases that use hydrogen peroxide to drive hydroxylation and decarboxylation of fatty acid substrates. We have expressed and purified a novel CYP152 family member - CYP152K6 from the methylotroph Bacillus methanolicus MGA3. CYP152K6 was characterized using spectroscopic, analytical and structural methods. CYP152K6, like its peroxygenase counterpart P450SPα (CYP152B1) from Sphingomonas paucimobilis, does not undergo significant fatty acid-induced perturbation to the heme spectrum, with the exception of a minor Soret shift observed on binding dodecanoic acid...
August 3, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29990749/integrin-%C3%AE-v-%C3%AE-3-receptor-targeting-pet-mri-dual-modal-imaging-probe-based-on-the-64-cu-labeled-manganese-ferrite-nanoparticles
#17
Xudong Shi, Langtao Shen
With the advent of positron emission tomography/magnetic resonance imaging (PET/MRI) scanner, PET/MRI dual-modal imaging will play more and more important role in the diagnosis of cancers and other diseases. Until now, there is no an approved PET/MRI dual-modal imaging probe. The goal of this work is to design and synthesize potential PET/MRI dual-modal imaging probe based on superparamagnetic manganese ferrite nanoparticles. We have developed superparamagnetic nanoparticles that have uniform size with 5 nm and can be further functionalized through surface coating with dopamine and polyethylene glycol derivatives, which provide functional groups for conjugating tumor-targeting biomolecules and bifunctional chelators...
July 6, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29990752/inhibitory-effect-of-melittin-on-endonuclease-like-activity-of-centrin
#18
Wenlong Zhang, Enxian Shi, Yaqin Zhao, Binsheng Yang
The xeroderma pigmentosum group C protein (XPC) and centrin2 are the primary initiators of global genome nucleotide excision repair (NER). Centrin, acts as a member of the EF-hand super family of calcium-binding proteins, playing roles in reconstitution of the vitro NER reaction. To understand the possible molecular and structural properties of the multiprotein process, the interactions of Euplotes octocarinatus centrin (EoCen), melittin, and DNA are described. EoCen shares a sequence identity of 66% with centrin2...
July 5, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29996087/magnetic-nanoparticles-as-a-support-for-a-copper-ii-complex-with-nuclease-activity
#19
Maria A S Silva, Adolfo I B Romo, Dieric S Abreu, Marta S P Carepo, Luis Lemus, Miguel Jafelicci, Tércio F Paulo, Otaciro R Nascimento, Esteban Vargas, Juliano C Denardin, Izaura C N Diógenes
Magnetic nanoparticles have been extensively explored for the development of platforms for drug delivery and imaging probes. In this work, we have used a modular capping strategy to produce magnetic gold-coated Fe3 O4 (Fe3 O4 @Au) nanoparticles, which have been decorated with a copper (II) complex containing a thioether derivative of clip-phen (Fe3 O4 @Au@Cu), where the complex [Cu(2CP-Bz-SMe)]2+ has affinity to bind DNA and proven nuclease activity (2CP-Bz-SMe=1,3-bis((1,10-phenanthrolin-2-yl)oxy)-N-(4-(methylthio)benzylidene)propan-2-imine)...
June 30, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29990748/cytotoxicity-dual-targeting-apoptosis-induction-evaluation-of-multinuclear-cu-complexes-based-on-pyrazine-benzimidazole-derivative
#20
Jiyong Hu, Shufang Chen, Ruina Mao, Chunli Liao, Hao Yang, Jin'an Zhao
To investigate the cytotoxicity and mechanism of action of multinuclear Cu complexes against tumor cell lines, two complexes, Cu6 (bpbib)4 Br8 (1) and Cu2 (bpbib)2 (BF4 )2 Cl2 (2) (bpbib = 1,4-bis((2-(pyrazin-2-yl)-1H-benzo[d]imidazol-1-yl)methyl)benzene) were synthesized and characterized. Both Cu complexes showed high selectivity toward cancer and not normal cells, and the SMMC7721 cell line showed most sensitivity toward both complexes. Complex 1 exhibited more potent cytotoxicity and enhanced cellular uptake, and therefore, was comprehensively investigated...
June 30, 2018: Journal of Inorganic Biochemistry
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