journal
https://read.qxmd.com/read/38527404/regulations-of-mitoneet-by-the-key-redox-homeostasis-molecule-glutathione
#1
JOURNAL ARTICLE
Cécile Mons, Myriam Salameh, Thomas Botzanowski, Martin Clémancey, Pierre Dorlet, Cindy Vallières, Stéphane Erb, Laurence Vernis, Olivier Guittet, Michel Lepoivre, Meng-Er Huang, Sarah Cianferani, Jean-Marc Latour, Geneviève Blondin, Marie-Pierre Golinelli-Cohen
Human mitoNEET (mNT) and CISD2 are two NEET proteins characterized by an atypical [2Fe-2S] cluster coordination involving three cysteines and one histidine. They act as redox switches with an active state linked to the oxidation of their cluster. In the present study, we show that reduced glutathione but also free thiol-containing molecules such as β-mercaptoethanol can induce a loss of the mNT cluster under aerobic conditions, while CISD2 cluster appears more resistant. This disassembly occurs through a radical-based mechanism as previously observed with the bacterial SoxR...
March 20, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38507993/a-new-copper-ii-complex-containing-long-chain-aliphatic-hydrazide-and-1-10-phenanthroline-upregulates-adp-hydrolysis-in-triple-negative-breast-cancer-cells
#2
JOURNAL ARTICLE
Helen Soares Valença Ferreira, Luana Munique Sousa Ramos, Fernanda Cardoso Silva, Daniel Lima Alves, Gabriele de Menezes Pereira, Pedro Henrique de Oliveira Santiago, Angelina Maria de Almeida, Javier Ellena, Pedro Paulo Corbi, Carolina Gonçalves Oliveira, Mauro Vieira de Almeida, Cristina Ribas Fürstenau, Dayanne Silva Borges, Raoni Pais Siqueira, Wendell Guerra, Thaise Gonçalves Araújo
Copper can be opportunely complexed to modulate oncogenic pathways, being a promising strategy for cancer treatment. Herein, three new copper(II) complexes containing long-chain aliphatic hydrazides and 1,10-phenanthroline (1,10-phen), namely, [Cu(octh)(1,10-phen)(H2 O)](NO3 )2 1, [Cu(dech)(1,10-phen)(H2 O)](NO3 )2 2 and [Cu(dodh)(1,10-phen)(H2 O)](NO3 )2 .H2 O 3 (where octh = octanoic hydrazide, dech = decanoic hydrazide, dodh = dodecanoic hydrazide) were successfully prepared and characterized by several physical-chemical methods...
March 16, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38522216/erbium-iii-complexes-with-fluoroquinolones-structure-and-biological-properties
#3
JOURNAL ARTICLE
Eleni Arnaouti, Christina Georgiadou, Antonios G Hatizdimitriou, Stavros Kalogiannis, George Psomas
Four erbium(III) complexes with the fluoroquinolones enrofloxacin, levofloxacin, flumequine and sparfloxacin as ligands were synthesized and characterized by a wide range of physicochemical and spectroscopic techniques as well as single-crystal X-ray crystallography. The compounds were evaluated for their activity against the bacterial strains Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Xanthomonas campestris, which was higher than that of the corresponding free quinolones. The interaction mode of the complexes with calf-thymus DNA is via intercalation, as suggested by diverse studies such as UV-vis spectroscopy, DNA-viscosity measurements and competitive studies with ethidium bromide...
March 15, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38522215/antifungal-activity-of-ruthenium-ii-complex-combined-with-fluconazole-against-drug-resistant-candida-albicans-in-vitro-and-its-anti-invasive-infection-in-vivo
#4
JOURNAL ARTICLE
Zhi-Chang Xu, Xiu-Rong Ma, Li-Juan Zhang, Hui-Ting Chen, Ding-Mei Qing, Rong-Tao Li, Rui-Rong Ye, Rui-Rui Wang
With the abuse of antibiotics and azoles, drug-resistant Candida albicans infections have increased sharply and are spreading rapidly, thereby significantly reducing the antifungal efficacy of existing therapeutics. Several patients die of fungal infections every year. Therefore, there is an urgent requirement to develop new drugs. Accordingly, we synthesized a series of polypyridyl ruthenium (II) complexes having the formula [Ru (NN)2 (bpm)] (PF6 )2 (N-N = 2,2'-bipyridine) (bpy, in Ru1), 1,10-phenanthroline (phen, in Ru2), 4,7-diphenyl-1,10-phenanthroline (DIP, in Ru3) (bpm = 2,2'-bipyrimidine) and studied their antifungal activities...
March 12, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38507994/tyrosine-nitration-of-glucagon-impairs-its-function-extending-the-role-of-heme-in-t2d-pathogenesis
#5
JOURNAL ARTICLE
Xiaoying Yin, Guoqi Ni, Xuan Zhang, Shitao Fu, Hailing Li, Zhonghong Gao
New studies raise the possibility that the higher glucagon (GCG) level present in type 2 diabetes (T2D) is a compensatory mechanism to enhance β-cell function, rather than induce dysregulated glucose homeostasis, due to an important role for GCG that acts directly within the pancreas on insulin secretion by intra-islet GCG signaling. However, in states of poorly controlled T2D, pancreatic α cell mass increases (overproduced GCG) in response to insufficient insulin secretion, indicating decreased local GCG activity...
March 12, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38489864/systematic-review-on-antibacterial-photodynamic-therapeutic-effects-of-transition-metals-ruthenium-and-iridium-complexes
#6
REVIEW
Anadil Gul, Munir Ahmad, Raza Ullah, Rizwan Ullah, Yan Kang, Wenchao Liao
The prevalence of antibiotic-resistant pathogenic bacteria poses a significant threat to public health and ranks among the principal causes of morbidity and mortality worldwide. Antimicrobial photodynamic therapy is an emerging therapeutic technique that has excellent potential to embark upon antibiotic resistance problems. The efficacy of this therapy hinges on the careful selection of suitable photosensitizers (PSs). Transition metal complexes, such as Ruthenium (Ru) and Iridium (Ir), are highly suitable for use as PSs because of their surface plasmonic resonance, crystal structure, optical characteristics, and photonics...
March 11, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38471286/characterization-of-ferredoxins-involved-in-electron-transfer-pathways-for-nitrogen-fixation-implicates-differences-in-electronic-structure-in-tuning-2-4fe4s-fd-activity
#7
JOURNAL ARTICLE
Nathan M Lewis, Effie C Kisgeropoulos, Carolyn E Lubner, Kathryn R Fixen
Ferredoxins (Fds) are small proteins which shuttle electrons to pathways like biological nitrogen fixation. Physical properties tune the reactivity of Fds with different pathways, but knowledge on how these properties can be manipulated to engineer new electron transfer pathways is lacking. Recently, we showed that an evolved strain of Rhodopseudomonas palustris uses a new electron transfer pathway for nitrogen fixation. This pathway involves a variant of the primary Fd of nitrogen fixation in R. palustris, Fer1, in which threonine at position 11 is substituted for isoleucine (Fer1T11I )...
March 7, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38460483/molecular-targets-of-cisplatin-in-hela-cells-explored-through-competitive-activity-based-protein-profiling-strategy
#8
JOURNAL ARTICLE
Yi Chen, Chenxi Wang, Meiling Qi, Yinyu Wei, Hongliang Jiang, Zhifeng Du
Cisplatin is widely used as anticancer drugs, and DNA is considered as the main target. Considering its high affinity towards cysteines and the important role of cystine containing proteins, we applied a competitive activity-based protein profiling strategy to identify protein cysteines that bind with cisplatin in HeLa cells. Living cells were treated with cisplatin at cytotoxic concentrations, then the protein was extracted. After labeling with desthiobiotin iodoacetamide (DBIA) probe, protein was precipitated, digested and isotopically labeled, subsequently the peptides were combined, and the biotinylated cysteine-containing peptides were enriched and quantified by LC-MS/MS...
March 6, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38460481/novel-titanocene-y-derivative-with-albumin-affinity-exhibits-improved-anticancer-activity-against-platinum-resistant-cells
#9
JOURNAL ARTICLE
Sergio Gomez-Lopez, Rosario Serrano, Boiko Cohen, Isabel Martinez-Argudo, Laura Lopez-Sanz, Marta Carmen Guadamillas, Raul Calero, Maria Jose Ruiz
The antitumor activity of Ti(IV)-based compounds put them in the spotlight for cancer treatment in the past, but their lack of stability in vivo due to a high rate of hydrolysis has hindered their development as antitumor drugs. As a possible solution for this problem, we have reported a synthesis strategy through which we combined a titanocene fragment, a tridentate ligand, and a long aliphatic chain. This strategy allowed us to generate a titanium compound (Myr-Ti) capable of interacting with albumin, highly stable in water and with cytotoxic activity in tumor cells[1]...
March 6, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38460482/polypyridyl-ruthenium-complexes-with-benzothiazole-moiety-as-membrane-disruptors-and-anti-resistance-agents-for-staphylococcus-aureus
#10
JOURNAL ARTICLE
Wei Deng, Chun-Yan Zhang, Li-Xin Dou, Li-Ting Huang, Jin-Tiao Wang, Xiang-Wen Liao, Li-Ping Wang, Ru-Jian Yu, Yan-Shi Xiong
Developing new antimicrobials to combat drug-resistant bacterial infections is necessary due to the increasing problem of bacterial resistance. In this study, four metallic ruthenium complexes modified with benzothiazoles were designed, synthesized and subjected to bio-evaluated. Among them, Ru-2 displayed remarkable inhibitory activity against Staphylococcus aureus (S. aureus) with a minimum inhibitory concentration (MIC) of 1.56 μg/mL. Additionally, it showcased low hemolytic toxicity (HC50  > 200 μg/mL) and the ability to effectively eradicate S...
March 5, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38471287/fluorination-of-porphyrin-%C3%AE-periphery-boosts-nickel-ii-catalyzed-hydrogen-evolution-reaction
#11
JOURNAL ARTICLE
Haozong Xue, Zhuo-Yan Wu, Jun-Long Zhang
Tunichlorin, the naturally occurring chlorophyll cofactor containing Ni(II) ion, sets up a golden standard for designing the electrocatalysts for hydrogen evolution reaction (HER) via β-peripheral modification. Besides the fine-tuning of the porphyrin β-periphery such as adjusting the aromatics (the saturated level of tetrapyrrole) or installing hydroxyl group (hydrogen bond network) to enhance the catalytic HER efficiency, here we report that β-fluorination of porphyrin is also an important approach to increase the reactivity of Ni(II) center...
March 2, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38490045/platinum-iv-drugs-with-cannabidiol-inducing-mitochondrial-dysfunction-and-synergistically-enhancing-anti-tumor-effects
#12
JOURNAL ARTICLE
Tangli Wei, Lihua Chen, Pengmin Shi, Changli Wang, Yusheng Peng, Jing Yang, Xiali Liao, Bo Yang, Chuanzhu Gao
Chemotherapy resistance is an insurmountable problem in clinical anticancer therapy. Although Oxaliplatin is an effective chemotherapeutic agent for the treatment of colorectal cancer (CRC), it still suffers from serious toxicities as well as drug resistance. In this work, three Oxaliplatin tetravalent platinum prodrugs(O1-O3) and three novel mixed ammine/amine analogs(C1-C3) were constructed, introducing cannabidiol with anti-tumor activity in their axial position. All Pt(IV) prodrugs exhibited potent antitumor effects in a variety of tumor cell lines, especially in HCT-116 cells, where complex O3 showed strong inhibitory effects with the half maximal inhibitory concentrations (IC50 ) value of 6...
March 1, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38422586/spectroscopy-and-absolute-quantum-efficiency-of-near-infrared-electrochemiluminescence-for-a-macrocyclic-palladium-complex
#13
JOURNAL ARTICLE
Congyang Zhang, Ruizhong Zhang, Ruijing Zhang, Qiao Zhang, Jun-Long Zhang Zhangjunlong Pku Edu Cn, Zhifeng Ding
Electrochemiluminescence (ECL) is widely applied as a reliable tool in clinical diagnosis, including immunoassays, cancer biomarker detection, etc. Metal complexes with emission in the near-infrared (NIR) range possess distinct features such as high transmission and minimal tissue auto-absorption, making them versatile for applications in biosensing and other fields. Through ECL spectral studies of an O-linked nonaromatic benzitripyrrin (C^N^N^N) macrocyclic palladium complex (Pd1) with multiple pyrrole structures, we observed emission peaks from the Qx (0,0) and its vibronic Qx (0,1) bands during both photoluminescence (PL) and ECL...
February 24, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38377623/thermoresponsive-carboplatin-releasing-prodrugs
#14
JOURNAL ARTICLE
Aemilia D McAdam, Lucinda K Batchelor, Jan Romano-deGea, Dmitry Vasilyev, Paul J Dyson
Platinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in anticancer treatment, however, clinically used platinum drugs have not been optimised for combination with hyperthermia. The derivatisation of existing anticancer drugs with appropriately chosen thermoresponsive moieties results in drugs being activated only at the heated site. Perfluorinated chains of varying lengths were installed on carboplatin, a clinically approved drug, leading to the successful synthesis of a series of mono- and di- substituted platinum(IV) carboplatin prodrugs...
February 15, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38412777/exploring-the-potential-of-the-vitamin-b-12-derivative-azidocobalamin-to-undergo-huisgen-1-3-dipolar-azide-alkyne-cycloaddition-reactions
#15
JOURNAL ARTICLE
Ben J Stackpole, Jessica M Fredericksen, Nicola E Brasch
There is considerable interest in using the metalloprotein cofactor vitamin B12 as a vehicle to deliver drugs and diagnostic agents into mammalian or bacterial cells by exploiting the B12 -specific active uptake pathways. Conjugation of the cargo via the β-axial site or the 5'-OH of the ribose of the nucleotide are the most desirable sites, to maximise intracellular uptake. Herein we show the potential of conjugation at the beta-azido ligand of the vitamin B12 derivative azidocobalamin via a click-type azide-alkyne 1,3-dipolar cycloaddition (Huisgen cycloaddition) reaction...
February 10, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38364337/the-green-cupredoxin-copi-is-a-multicopper-protein-able-to-oxidize-cu-i
#16
JOURNAL ARTICLE
Melanie Rossotti, Diletta Arceri, Pascal Mansuelle, Olivier Bornet, Anne Durand, Soufian Ouchane, Hélène Launay, Pierre Dorlet
Anthropogenic activities in agriculture and health use the antimicrobial properties of copper. This has led to copper accumulation in the environment and contributed to the emergence of copper resistant microorganisms. Understanding bacterial copper homeostasis diversity is therefore highly relevant since it could provide valuable targets for novel antimicrobial treatments. The periplasmic CopI protein is a monodomain cupredoxin comprising several copper binding sites and is directly involved in copper resistance in bacteria...
February 8, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38342077/stabilization-of-a-cu-binding-site-by-a-highly-conserved-tryptophan-residue
#17
JOURNAL ARTICLE
Yuri Rafael de Oliveira Silva, Dia Zheng, Stephen C Peters, Oriana S Fisher
Copper serves as an essential cofactor for nearly all living organisms. There are still many gaps remaining in our knowledge of how Gram-positive bacteria import copper and maintain homeostasis. To obtain a better understanding of how these processes work, here we focus on the ycnKJI operon responsible for regulating copper levels in the Gram-positive bacterium Bacillus subtilis. This operon encodes three Cu-related proteins: a copper-dependent transcriptional repressor (YcnK), a putative copper importer (YcnJ), and a copper-binding protein of unknown function (YcnI)...
February 7, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38335582/a-pt-ii-complex-bearing-n-heterocycle-ring-induced-ferroptotic-cell-death-in-ovarian-cancer
#18
JOURNAL ARTICLE
Xiaomin Shen, Yue Peng, Haixia Zhou, Xiaoxia Ye, Zhong Han, Xiangchao Shi
Cisplatin is a widely used chemotherapeutic agent which interacts with DNA to form Pt-DNA adducts, leading to DNA double-strand breaks and apoptosis. Resistance is the major obstacle in the clinical application of cisplatin. A quinoline derivative based Pt(II) complex PtQ was synthesized and characterized. As an analogue of cisplatin, PtQ demonstrated a novel anticancer mechanism in ovarian cancer. PtQ caused excessive production of reactive oxygen species (ROS), which triggered ferroptotic cell death in ovarian cancer...
February 6, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38301386/determination-of-the-role-of-specific-amino-acids-in-the-binding-of-zn-ii-ni-ii-and-cu-ii-to-the-active-site-of-the-m10-family-metallopeptidase
#19
JOURNAL ARTICLE
Paulina Potok, Martyna Zawada, Sławomir Potocki
Metallopeptidases are a group of metal-dependent enzymes that hydrolyze peptide bonds. These enzymes found in Streptococcus pneumoniae assist the pathogen in infecting the host by breaking down host tissues and extracellular matrix proteins. Considering metallopeptidases' significant role in bacterial virulence, inhibiting this enzyme represents a promising avenue for research. These enzymes are characterized by the presence of Zn(II) in the active site, proper coordination of which is essential for their catalytic function...
January 27, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38330683/the-structure-of-the-diheme-cytochrome-c-4-from-neisseria-gonorrhoeae-reveals-multiple-contributors-to-tuning-reduction-potentials
#20
JOURNAL ARTICLE
Fangfang Zhong, Morgan E Reik, Michael J Ragusa, Ekaterina V Pletneva
Cytochrome c4 (c4 ) is a diheme protein implicated as an electron donor to cbb3 oxidases in multiple pathogenic bacteria. Despite its prevalence, understanding of how specific structural features of c4 optimize its function is lacking. The human pathogen Neisseria gonorrhoeae (Ng) thrives in low oxygen environments owing to the activity of its cbb3 oxidase. Herein, we report characterization of Ng c4 . Spectroelectrochemistry experiments of the wild-type (WT) protein have shown that the two Met/His-ligated hemes differ in potentials by ∼100 mV, and studies of the two His/His-ligated variants provided unambiguous assignment of heme A from the N-terminal domain of the protein as the high-potential heme...
January 24, 2024: Journal of Inorganic Biochemistry
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