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Journal of Inorganic Biochemistry

Nina Horn, Lisbeth Birk Møller, Valeria Marina Nurchi, Jan Aaseth
Dysregulation of copper homeostasis in humans is primarily found in two genetic diseases of copper transport, Menkes and Wilson diseases, which show symptoms of copper deficiency or overload, respectively. However, both diseases are copper storage disorders despite completely opposite clinical pictures. Clinically, Menkes disease is characterized by copper deficiency secondary to poor loading of copper-requiring enzymes although sufficient body copper. Copper accumulates in non-hepatic tissues, but is deficient in blood, liver, and brain...
October 23, 2018: Journal of Inorganic Biochemistry
Sebastian Kallus, Lukas Uhlik, Sushilla van Schoonhoven, Karla Pelivan, Walter Berger, Éva A Enyedy, Thilo Hofmann, Petra Heffeter, Christian R Kowol, Bernhard K Keppler
Triapine, the most prominent anticancer drug candidate from the substance class of thiosemicarbazones, was investigated in >30 clinical phase I and II studies. However, the results were rather disappointing against solid tumors, which can be explained (at least partially) due to inefficient delivery to the tumor site. Hence, we synthesized the first biotin-functionalized thiosemicarbazone derivatives in order to increase tumor specificity and accumulation. Additionally, for Triapine and one biotin conjugate the iron(III) and copper(II) complexes were prepared...
October 19, 2018: Journal of Inorganic Biochemistry
Ellis J Wilde, Elena V Blagova, Thomas J Sanderson, Daniel J Raines, Ross P Thomas, Anne Routledge, Anne-Kathrin Duhme-Klair, Keith S Wilson
A mimic of the tetradentate stealth siderophore salmochelin S1, was synthesised, characterised and shown to form Fe(III) complexes with ligand-to-metal ratios of 1:1 and 3:2. Circular dichroism spectroscopy confirmed that the periplasmic binding proteins CeuE and VctP of Campylobacter jejuni and Vibrio cholerae, respectively, bind the Fe(III) complex of the salmochelin mimic by preferentially selecting Λ-configured Fe(III) complexes. Intrinsic fluorescence quenching studies revealed that VctP binds Fe(III) complexes of the mimic and structurally-related catecholate ligands, such as enterobactin, bis(2, 3-dihydroxybenzoyl-l-serine) and bis(2, 3-dihydroxybenzoyl)-1, 5-pentanediamine with higher affinity than does CeuE...
October 19, 2018: Journal of Inorganic Biochemistry
Na Chen, Meng Lin, Na Liu, Shanshan Wang, Xianjin Xiao
Methylmercury (MeHg) is a widespread environmental pollutant and causes a serious hazard to testicular development and spermatogenesis. However, molecular mechanisms underlying male reproductive toxicity induced by MeHg remain elusive. The objective of this study was to explore the effects of MeHg on autophagy induction in germ cells (GCs). In this study, we showed that orally administered MeHg 10 mg/kg per day for five consecutive days resulted in reduced sperm count and impaired sperm motility. Noteworthy, MeHg impaired the seminiferous tubule of rats and increased the apoptotic index of GCs of rats...
October 18, 2018: Journal of Inorganic Biochemistry
Jie Zhao, Wanxia Gao, Zhen Yang, Hailing Li, Zhonghong Gao
It is known that copper ion (Cu(II)) binds to amyloid-β peptide (Aβ), induces Aβ oligomer formation and ultimately exacerbates Aβ-aggregation neurotoxicity in Alzheimer's disease (AD). It becomes interesting to know that how this chemical modification of Aβ would affect interaction of Aβ and Cu(II) and their roles in the development of AD. In this work, we investigated the interaction of Aβ1-42 nitration with the toxic Cu(II). It showed that Cu(II)induced Aβ1-42 nitration in the presence of nitrite and hydrogen peroxide...
October 16, 2018: Journal of Inorganic Biochemistry
Xiangchao Shi, Hongbao Fang, Yan Guo, Hao Yuan, Zijian Guo, Xiaoyong Wang
Copper complexes are hopeful anticancer drugs due to their multifacet biological properties and high biocompatibility. Inflammatory environment plays an important role in tumor progression and affects the body response to chemotherapeutic agents. A copper(II) complex CuLA with a phenanthroline derivative N-(1,10-phenanthrolin-5-yl)-nonanamide (L) and two aspirin anions (A) as the ligands was synthesized. CuLA effectively induces mitochondrial dysfunction and promotes early-apoptosis in SKOV-3 cells; moreover, it suppresses the expression of cyclooxygenase-2, a key enzyme involved in inflammatory response, in lipopolysaccharide stimulated RAW 264...
October 15, 2018: Journal of Inorganic Biochemistry
Snežana Bjelogrlić, Tamara R Todorović, Ilija Cvijetić, Marko V Rodić, Miroslava Vujčić, Sanja Marković, Jovana Araškov, Barbara Janović, Fathi Emhemmed, Christian D Muller, Nenad R Filipović
A novel binuclear Cd complex (1) with hydrazone-based ligand was prepared and characterized by spectroscopy and single crystal X-ray diffraction techniques. Complex 1 reveals a strong pro-apoptotic activity in both human, mammary adenocarcinoma cells (MCF-7) and pancreatic AsPC-1 cancer stem cells (CSCs). While apoptosis undergoes mostly caspase-independent, 1 stimulates the activation of intrinsic pathway with noteworthy down regulation of caspase-8 activity in respect to non-treated controls. Distribution of cells over mitotic division indicates that 1 caused DNA damage in both cell lines, which is confirmed in DNA interaction studies...
October 14, 2018: Journal of Inorganic Biochemistry
Kristine L Kay, Chris J Hamilton, Nick E Le Brun
CopA is a Cu(I)-exporting transmembrane P1B -type ATPase from Bacillus subtilis. It contains two N-terminal cytoplasmic domains, CopAab, which bind Cu(I) with high affinity and to form higher-order complexes with multiple Cu(I) ions. To determine the precise nature of these species, electrospray ionisation mass spectrometry (ESI-MS) under non-denaturing conditions was employed. Up to 1 Cu per CopAab resulted in Cu coordination to one or both CopAab domains. At >1 Cu/CopAab, two distinct dimeric charge state envelopes were observed, corresponding to distinct conformations, each with Cu6 (CopAab)2 as its major form...
October 13, 2018: Journal of Inorganic Biochemistry
Huajian Lin, Jincan Chen, Yaxin Zhang, Azeem Ulla, Jianyong Liu, Fan Lin, Longguang Jiang, Mingdong Huang
Antimicrobial photodynamic therapy (aPDT) is an effective way to combat infectious diseases and antibiotic resistance. Photosensitizer is a key factor of aPDT and has triggered extensive research interest. In this study, a new asymmetric Zn(II) phthalocyanine mono-substituted with a triazatricyclodecane moiety (compound 3) and its cationic N-methylated derivative (compound 4) were synthesized. Their photodynamic antimicrobial activities were evaluated using bioluminescent bacterial strains. Compound 3 showed phototoxicity only toward the Gram-positive bacteria, whereas the cationic derivative compound 4 exhibited strong anti-bacterial activity against both Gram-positive and Gram-negative strains...
October 6, 2018: Journal of Inorganic Biochemistry
Mauro Ravera, Elisabetta Gabano, Diego Bonzani, Ilaria Zanellato, Aldo Arrais, Simone Cantamessa, Marco Biggiogera, Domenico Osella
Nonporous silica nanoparticles with an external shell containing the 3‑aminopropyl arm (SiNP) were further decorated with alginic acid (SiNP-ALG) as a potential biocompatible delivery system for Pt antitumor agents. Such particles were coupled with the prodrug (OC‑6‑44)‑acetato(β‑alaninato)diamminedichloridoplatinum(IV), 1, through the formation of amide bonds between the pendant carboxylate groups on SiNP-ALG and the free amino group of the complex. Cytosol extracted from tumor cells was able to quickly and efficiently reduce the Pt(IV) prodrug, and produces the active metabolite cisplatin...
October 2, 2018: Journal of Inorganic Biochemistry
Manas Sutradhar, Alexandra R Fernandes, Fabiana Paradinha, Patricia Rijo, Catarina Garcia, Catarina Roma-Rodrigues, Armando J L Pombeiro, Adília Januário Charmier
Herein, we report the first example of the synthesis of a novel type of Cu(II) complex based on a natural product ligand derived from carvacrol. The copper(II) complex [Cu(DCA)2 (EtOH)]2 ·2EtOH (1, HDCAO-carvacrotinic acid) has been synthesized and characterized by elemental analysis, IR spectroscopy, ESI-MS and single crystal X-ray analysis. Complex 1 and the carvacrotinic acid (2, HDCA) have been studied towards their antimicrobial and antiproliferative activities. For both compounds the antimicrobial activity was assessed against a panel of Gram-positive and Gram-negative bacteria and yeasts...
September 29, 2018: Journal of Inorganic Biochemistry
Yanwei Wang, Xingqi Ji, Shuya Dai, Haitao Liu, Dandan Yan, Yang Zhou, Jie Gu, Haifeng Shi
Human exposure to cadmium (Cd) could lead to alterations in lipid metabolism. However, the underlying mechanism is still unclear. In the present study, the data revealed that Cd exposure induced cholesterol redistribution both in vivo from mouse liver tissue into the serum, and in vitro from the HepG2 cells to the cultured medium, which were associated with modulating the expressions of cholesterol efflux proteins, including upregulating cholesterol exporter ATP-binding cassette transporter A1 (ABCA1) and downregulating oxysterol-binding protein (OSBP)...
September 29, 2018: Journal of Inorganic Biochemistry
Alketa Tarushi, George D Geromichalos, Dimitris P Kessissoglou, George Psomas
The in vitro and in silico biological properties of two manganese complexes with the non-steroidal anti-inflammatory drug mefenamic acid (Hmef) in the presence or absence of salicylaldoxime (Η2 sao), i.e. [Μn6 (O)2 (mef)2 (sao)6 (CH3 OH)4 ] 1, and [Μn(mef)2 (CH3 OH)4 ] 2, respectively, are presented in the present contribution. More specifically, the in vitro biological activity of the complexes was investigated by studying their affinity to calf-thymus DNA (by diverse spectroscopic and physicochemical techniques) and their binding towards bovine (BSA) or human serum albumin (HSA) (by fluorescence emission spectroscopy)...
September 29, 2018: Journal of Inorganic Biochemistry
Mirela M Barsan, Marie-Josée Bellemare, Ian S Butler, Denis F R Gilson, D Scott Bohle
The effect of pressure on the Raman and fluorescence spectra of hematin anhydride (β-hematin) is reported. In a diamond-anvil cell, DAC, with applied pressures up to 41 kbar, the Raman spectrum undergoes a series of intensity enhancements and increases in energy for many of the Raman-active bands up to a pressure of ~27 kbar. At higher pressures, there is either a leveling out or a decrease in the energies of these vibrational modes. The fluorescence bands also undergo a series of pressure- sensitive changes where, up to 10 kbar, there is a marked quenching of the intensity of the emissive bands, which is accompanied by a net increase in energy of the vibrational bands...
September 24, 2018: Journal of Inorganic Biochemistry
Ting Meng, Qi-Pin Qin, Zhen-Rui Wang, Li-Ting Peng, Hua-Hong Zou, Zhen-Yuan Gan, Ming-Xiong Tan, Kai Wang, Fu-Pei Liang
Eight new platinum(II) complexes Pt1-Pt8 with substituted 3‑(2'‑benzimidazolyl) coumarins were successfully synthesized and characterized by single crystal X-ray diffraction analysis, nuclear magnetic resonance spectroscopy (NMR), electrospray ionization-mass spectrometry (ESI-MS), infrared spectrophotometry (IR) and elemental analysis. Crystallographic data of these Pt1-Pt8 complexes showed that the Pt(II) has distorted four-coordinated square planar geometry. Pt1-Pt8 were found to display high cytotoxic activity in vitro against the cisplatin-resistant SK-OV-3/DDP cancer cells with a low IC50 from 1...
September 24, 2018: Journal of Inorganic Biochemistry
Steffen Brünle, Juliane Poppe, Ron Hail, Ulrike Demmer, Ulrich Ermler
No abstract text is available yet for this article.
September 21, 2018: Journal of Inorganic Biochemistry
Yali Han, Zhenzhen Tian, Shumiao Zhang, Xicheng Liu, Juanjuan Li, Yanru Li, Yi Liu, Min Gao, Zhe Liu
Series of half-sandwich IrIII N-heterocyclic carbene (NHC) antitumor complexes [(η5 -Cp*)Ir(C^C)Cl] have been synthesized and characterized (Cp* is pentamethyl cyclopentadienyl, and C^C are four NHC chelating ligands containing phenyl rings at different positions). IrIII complexes showed potent antitumor activity with IC50 values ranged from 3.9 to 11.8 μM against A549 cells by the MTT assay. Complexes can catalyze the conversion of the coenzyme NADH to NAD+ and induce the production of reactive oxygen species (ROS), and bonding to BSA by static quenching mode...
September 20, 2018: Journal of Inorganic Biochemistry
J P Bugarinović, M S Pešić, A Minić, J Katanić, D Ilić-Komatina, A Pejović, V Mihailović, D Stevanović, B Nastasijević, I Damljanović
A series of ferrocenes which contain dinitrogen-fused pyrazolidinone ring were synthesized from acryloylferrocene (4) and N,N'‑cyclic azomethine imines (3). Novel 5‑aryl‑6‑ferrocenoyltetrahydropyrazolo[1,2‑a]pyrazol‑1(5H)-ones were obtained as mixtures of two diastereoisomers (trans and cis) which were separated and isolated as pure substances. Ortho-substituted N,N'‑cyclic azomethine imines 5-oxo-2-(2,4,6-trimethylbenzylidene)pyrazolidin-2-ium-1-ide (3e) and 2-(2-methoxybenzylidene)-5-oxopyrazolidin-2-ium-1-ide (3f) reacted stereoselectively affording only trans-6-ferrocenoyl-5-mesityltetrahydropyrazolo[1,2-a]pyrazol-1(5H)-one (5e) and 6-ferrocenoyl-5-(2-methoxyphenyl)tetrahydropyrazolo[1,2-a]pyrazol-1(5H)-one (5f)...
September 20, 2018: Journal of Inorganic Biochemistry
Katarzyna Krupa, Monika Lesiów, Kamila Stokowa-Sołtys, Radosław Starosta, Natalia Ptaszyńska, Anna Łęgowska, Krzysztof Rolka, Maciej Wernecki, Magdalena Cal, Małgorzata Jeżowska-Bojczuk
Fusobacterium nucleatum is an anaerobic, Gram-negative bacteria linked to colon cancer. It is interesting to determine how metal ions interact with bacterial adhesin proteins. To this end, the coordination of ATDAAS-NH2 and MKKFL-NH2 fragments of Fusobacterium adhesin A (FadA) to copper(II) ions was studied by potentiometry, spectroscopic techniques (UV-Vis, CD, EPR and NMR) and the density functional theory (DFT) methods. At pH 6.8 (colon physiological pH), the metal ion in the first peptide (ATDAAS-NH2 ) is coordinated by one oxygen and three nitrogen donors while in the second one (MKKFL-NH2 ) - by sulfur and three nitrogen atoms...
September 18, 2018: Journal of Inorganic Biochemistry
Dušan Ćoćić, Snežana Jovanović, Snežana Radisavljević, Jana Korzekwa, Andreas Scheurer, Ralph Puchta, Dejan Baskić, Danijela Todorović, Suzana Popović, Sanja Matić, Biljana Petrović
Four new complexes [Pd(H2 LtBu )Cl]Cl (Pd1), [Pt(H2 LtBu )Cl]Cl (Pt1), [Pd(Me2 LtBu )Cl]Cl (Pd2) and [Pt(Me2 LtBu )Cl]Cl (Pt2) (where H2 LtBu  = 2,6-bis(5-(tert-butyl)-1H-pyrazol-3-yl)pyridine and Me2 LtBu  = 2,6-bis(5-(tert-butyl)-1-methyl-1H-pyrazol-3-yl)pyridine) were synthesized and characterized by elemental microanalysis, IR, 1 H NMR and ESI-MS methods. The reactivity of complexes towards thiourea (Tu), l-methionine (l-Met), l-cysteine (l-Cys) and guanosine-5'-monophosphate (5'-GMP) was investigated...
September 17, 2018: Journal of Inorganic Biochemistry
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