journal
MENU ▼
Read by QxMD icon Read
search

Clinical Science (1979-)

journal
https://www.readbyqxmd.com/read/29122967/hepatic-accumulation-of-s-adenosylmethionine-in-hamsters-with-non-alcoholic-fatty-liver-disease-associated-to-metabolic-syndrome-under-selenium-and-vitamin-e-deficiency
#1
Josep M Del Bas, Benjamín Rodríguez, Francesc Puiggròs, Silvia Mariné, Miguel Angel Rodríguez, David Moriña, Lluís Armengol, Antoni Caimari, Lluís Arola
Progression of non-alcoholic fatty liver disease (NAFLD) in the context of metabolic syndrome (MetS) is only partially explored due to the lack of preclinical models. In order to study the alterations in hepatic metabolism that accompany this condition, we developed a model of MetS accompanied by the onset of steatohepatitis (NASH) by challenging golden hamsters with a high fat diet low in vitamin E and selenium (HFD), since combined deficiency results in hepatic necroinflammation in rodents. Metabolomics and transcriptomics integrated analyses of livers revealed an unexpected accumulation of hepatic S-Adenosylmethionine (SAM) when compared with healthy livers likely due to diminished methylation reactions and repression of GNMT...
November 9, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29109300/the-shifted-balance-between-circulating-follicular-regulatory-t-cells-and-follicular-helper-t-cells-in-patients-with-ulcerative-colitis
#2
Xinrui Wang, Yonggang Zhu, Manli Zhang, Jie Hou, Hongjuan Wang, Yanfang Jiang, Haifeng Wang, Pujun Gao
B cell immunity participates in the pathogenesis of ulcerative colitis (UC). The immune balance between follicular regulatory T (TFR) cells and follicular helper T (TFH) cells is important in regulating B cell responses. However, the alteration of TFR/TFH balance in UC remains unclear. Peripheral blood from 25 UC patients and 15 healthy controls was examined for the frequencies of circulating TFR, TFH, and regulatory T (Treg) cells by flow cytometry. Levels of serum cytokines were measured using cytometric bead array (CBA)...
November 6, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29101299/relaxin-contributes-to-the-regulation-of-arterial-pressure-in-adult-female-mice
#3
Katrina M Mirabito Colafella, Chrishan S Samuel, Kate M Denton
Relaxin is increasingly being recognized as a potent vasodilatory and anti-fibrotic hormone. Given that relaxin is present in the circulation during luteal phase of the menstrual cycle and during pregnancy, when arterial pressure is lowest in women, relaxin may contribute to the relative cardiovascular protection observed in premenopausal women as compared to age-matched men and post-menopausal women. In the present study, we investigated the contribution of relaxin to the normal regulation of arterial pressure in adult female and male mice and during pregnancy...
November 3, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29101298/loss-of-microrna-22-prevents-high-fat-diet-induced-dyslipidemia-and-increases-energy-expenditure-without-affecting-cardiac-hypertrophy
#4
Gabriela Placoná Diniz, Zhan-Peng Huang, Jianming Liu, Jinghai Chen, Jian Ding, Renata Inzinna Fonseca, Maria Luiza Barreto-Chaves, Jose Donato, Xiaoyun Hu, Da-Zhi Wang
Obesity is associated with development of diverse diseases, including cardiovascular diseases and dyslipidemia. MiRNA-22 (miR-22) is a critical regulator of cardiac function and targets genes involved in metabolic processes. Previously we generated miR-22 null mice and we showed that loss of miR-22 blunted cardiac hypertrophy induced by mechanohormornal stress. In this study, we examined the role of miR-22 in the cardiac and metabolic alterations promoted by high fat (HF) diet. We found that loss of miR-22 attenuated the gain of fat mass and prevented dyslipidemia induced by HF diet, although the body weight gain, or glucose intolerance and insulin resistance did not seem to be affected...
November 3, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29101297/mesenchymal-stromal-cells-improve-human-islet-function-through-released-products-and-extracellular-matrix
#5
Ahmed A Arzouni, Andreia Vargas-Seymour, Chloe L Rackham, Paramjeet Dhadda, Guo-Cai Huang, Pratik Choudhary, Nance Nardi, Aileen J F King, Peter M Jones
Aims: The aims of the current study were (i) to determine whether the reported beneficial effects of mesenchymal stromal cells (MSCs) on mouse islet function extend to clinically relevant human tissues (islets and MSCs), enabling translation into improved protocols for clinical human islet transplantation; and (ii) to identify possible mechanisms through which human MSCs influence human islet function. Materials and methods: Human islets were co-cultured with human adipose tissue-derived MSCs (hASCs) or pretreated with its products - extracellular matrix (ECM) and annexin A1 (ANXA1)...
November 3, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29097626/glp-1-response-to-sequential-mixed-meals-influence-of-insulin-resistance
#6
Eleni Rebelos, Brenno Astiarraga, Roberto Bizzotto, Andrea Mari, Maria Laura Manca, Alex Gonzalez, Armando Mendez, Claudia A Martinez, Barry E Hurwitz, Ele Ferrannini
Previous work has shown that potentiation of insulin release is impaired in non-diabetic insulin resistance; we tested the hypothesis that this defect may be related to altered GLP-1 release. On consecutive days, 82 non-diabetic individuals, classified as insulin sensitive (IS, n=41) or insulin resistant (IR, n=41) by euglycaemic clamp, were given two sequential mixed meals with standard (75 g, LCD) or double (150 g, HCD) carbohydrate content. Plasma glucose, insulin, C-peptide, NEFA and GLP-1 concentrations were measured; β-cell function (glucose sensitivity and potentiation) was resolved by mathematical modelling...
November 2, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29097625/autoantibodies-against-at1-and-%C3%AE-1-adrenergic-receptors-predict-arterial-stiffness-progression-in-normotensive-subjects-over-a-5-year-period
#7
Gang Li, Zhe Cao, Xiao-Wei Wu, Hui-Kun Wu, Yi Ma, Bin Wu, Wei-Qing Wang, Jian Cheng, Zi-Hua Zhou, Yuan-Chao Tu
Objective: Arterial stiffness is an independent indicator of cardiovascular risk. Autoantibodies (AAs) against angiotensin AT1 receptor (AT1-AAs) and α1-Adrenergic receptor (α1-AAs) are important in the pathogenesis of hypertension. We identified the types of AT1-AAs and α1-AAs in normotensive subjects, with the aim of determining whether these antibodies predict aortic stiffness progression. Methods: Carotid-femoral pulse wave velocity (cf-PWV) was used to measure aortic stiffness. Overall, 816 subjects (71% of those invited) underwent a medical examination and evaluation of aortic stiffness...
November 2, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29054861/regulation-of-human-feto-placental-endothelial-barrier-integrity-by-vascular-endothelial-growth-factors-competitive-interplay-between-vegf-a165a-vegf-a165b-pigf-and-ve-cadherin
#8
Vincent Pang, David O Bates, Lopa Leach
The human placenta nourishes and protects the developing fetus whilst influencing maternal physiology for fetal advantage. It expresses several members of the VEGF family including the pro-angiogenic/pro-permeability VEGF-A165a isoform, the anti-angiogenic VEGF-A165b, placental growth factor (PIGF) and their receptors, VEGFR1 and VEGFR2. Alterations in the ratio of these factors during gestation and in complicated pregnancies have been reported; however the impact of this on feto-placental endothelial barrier integrity is unknown...
October 20, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29054860/post-prandial-hyperlipidaemia-results-in-systemic-nitrosative-stress-and-impaired-cerebrovascular-function-in-the-aged
#9
Christopher J Marley, Danielle Hodson, Julien V Brugniaux, Lewis Fall, Damian Miles Bailey
Post-prandial hyperlipidaemia (PPH) acutely impairs systemic vascular endothelial function, potentially attributable to a free radical-mediated reduction in vascular nitric oxide (NO) bioavailability (oxidative-nitrosative stress). However, it remains to be determined whether this extends to the cerebrovasculature. To examine this, 38 (19 young (≤ 35 years) and 19 aged (≥ 60 years)) healthy males were recruited. Cerebrovascular function (middle cerebral artery velocity, MCAv) and cerebrovascular reactivity to hypercapnea (CVRCO2Hyper) and hypocapnea (CVRCO2Hypo) were determined via trans-cranial Doppler ultrasound and capnography...
October 20, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29042489/alterations-in-endothelin-type-b-receptor-contribute-to-microvascular-dysfunction-in-women-who-have-had-preeclampsia
#10
Anna E Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M Alexander
Microvascular dysfunction originating during a preeclamptic pregnancy persists postpartum and likely contributes to increased CVD risk in these women. One putative mechanism contributing to this dysfunction is increased vasoconstrictor sensitivity to endothelin-1 (ET-1), mediated by alterations in ET-1 receptor type-B (ETBR). We evaluated ET-1 sensitivity, ETAR and ETBR contributions to ET-1-mediated constriction, and the mechanistic role of  ETBR in endothelium-dependent dilation in vivo in the microvasculature of postpartum women who had preeclampsia (PrEC, n=12) and control women who had a healthy pregnancy (HC, n=12)...
October 17, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29042488/natural-killer-cells-mediate-pathophysiology-in-response-to-reduced-uterine-perfusion-pressure
#11
Jamil Elfarra, Lorena M Amaral, Maggie McCalmon, Jeremy D Scott, Mark W Cunningham, Ashley Gnam, Tarek Ibrahim, Babbette LaMarca, Denise C Cornelius
Preeclampsia is associated with hypertension, small-for-gestational-age babies and increased cytolytic natural killer (NK) cells. The specific role of cytolytic NK cells in the pathophysiology of preeclampsia has not been clearly defined. We hypothesized that Reduced Uterine Perfusion Pressure (RUPP) stimulates proliferation and cytolytic activation of NK cells, and that reducing NK cells in RUPP would prevent hypertension, intrauterine growth restriction, and inflammation in response to placental ischemia...
October 17, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29021222/the-perivascular-pathways-for-influx-of-cerebrospinal-fluid-are-most-efficient-in-the-midbrain
#12
Howard Dobson, Matthew MacGregor Sharp, Richard Cumpsty, Theodore P Criswell, Tyler Wellman, Ciara Finucane, Jenna M Sullivan, Roy O Weller, Ajay Verma, Roxana O Carare
Although there are no conventional lymphatic vessels in the brain, fluid and solutes drain along basement membranes of cerebral capillaries and arteries towards the subarachnoid space and cervical lymph nodes. Convective influx/glymphatic entry of the cerebrospinal fluid (CSF) into the brain parenchyma occurs along the pial-glial basement membranes of arteries. This project tested the hypotheses that pial-glial basement membranes of arteries are thicker in the midbrain, allowing more glymphatic entry of CSF...
October 11, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28982724/the-structure-of-the-perivascular-compartment-in-the-old-canine-brain-a-case-study
#13
Theodore P Criswell, Matthew MacGregor Sharp, Howard Dobson, Ciara Finucane, Roy O Weller, Ajay Verma, Roxana O Carare
Dilatation of periarteriolar spaces in MRI of the ageing human brains occurs in white matter, basal ganglia and midbrain but not in cerebral cortex. Perivenous collagenous occurs in periventricular but not in subcortical white matter. Here we test the hypotheses that (a) the capacity for dilatation of periarteriolar spaces correlates with the anatomical distribution of leptomeningeal cells coating intracerebral arteries; (b) the regional development of perivenous collagenous in the white matter correlates with the population of intramural cells in the walls of veins...
October 5, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28963438/dlx3-promotes-bone-marrow-mesenchymal-stem-cells-proliferation-through-h19-mir-675-axis
#14
Na Zhao, Li Zeng, Yang Liu, Dong Han, Haochen Liu, Jian Xu, Yuxi Jiang, Cuiying Li, Tao Cai, Hailan Feng, Yixiang Wang
The underlying molecular mechanism of the increased bone mass phenotype in Tricho-dento-osseous (TDO) syndrome remains largely unknown. Our previous study has shown that the TDO point mutation c.533A>G, Q178R in DLX3 could increase bone density in a TDO patient and transgenic mice partially through delaying senescence in bone marrow mesenchymal stem cells (BMSCs). In the present study, we provided a new complementary explanation for TDO syndrome: the DLX3 (Q178R) mutation increased BMSCs proliferation through H19/miR-675 axis...
September 28, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29109303/insulin-resistance-and-reduced-metabolic-flexibility-cause-or-consequence-of-nafld
#15
EDITORIAL
Amalia Gastaldelli
Whether non-alcoholic fatty liver disease (NAFLD) precedes insulin resistance (IR) or IR preludes/causes NAFLD has been long debated. Recent studies have shown that there are two phenotypes of NAFLD, 'genetic' vs 'metabolic' NAFLD. The former patients are more at risk of hepatocellular carcinoma and chronic liver disease the latter are more IR and at increased risk of type 2 diabetes (T2D). Even if they are not yet diabetics, from a metabolic point of view having NAFLD is equivalent to T2D with reduced peripheral glucose disposal and impaired suppression of hepatic glucose production, but without fasting hyperglycaemia...
November 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29109302/inflammation-regulated-mrna-stability-and-the-progression-of-vascular-inflammatory-diseases
#16
REVIEW
Allison B Herman, Michael V Autieri
Cardiovascular disease remains a major medical and socioeconomic burden in developed and developing societies, and will increase with an aging and increasingly sedentary society. Vascular disease and atherosclerotic vascular syndromes are essentially inflammatory disorders, and transcriptional and post-transcriptional processes play essential roles in the ability of resident vascular and inflammatory cells to adapt to environmental stimuli. The regulation of mRNA translocation, stability, and translation are key processes of post-transcriptional regulation that permit these cells to rapidly respond to inflammatory stimuli...
November 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29109301/personalized-medicine-a-modern-approach-for-the-diagnosis-and-management-of-hypertension
#17
REVIEW
Carmine Savoia, Massimo Volpe, Guido Grassi, Claudio Borghi, Enrico Agabiti Rosei, Rhian M Touyz
The main goal of treating hypertension is to reduce blood pressure to physiological levels and thereby prevent risk of cardiovascular disease and hypertension-associated target organ damage. Despite reductions in major risk factors and the availability of a plethora of effective antihypertensive drugs, the control of blood pressure to target values is still poor due to multiple factors including apparent drug resistance and lack of adherence. An explanation for this problem is related to the current reductionist and 'trial-and-error' approach in the management of hypertension, as we may oversimplify the complex nature of the disease and not pay enough attention to the heterogeneity of the pathophysiology and clinical presentation of the disorder...
November 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28982723/increased-galectin-3-levels-are-associated-with-abdominal-aortic-aneurysm-progression-and-inhibition-of-galectin-3-decreases-elastase-induced-aaa-development
#18
Carlos-Ernesto Fernandez-García, Carlos Tarin, Raquel Roldan-Montero, Diego Martinez-Lopez, Monica Torres-Fonseca, Jes S Lindhot, Melina Vega de Ceniga, Jesus Egido, Natalia Lopez-Andres, Luis-Miguel Blanco-Colio, Jose-Luis Martín-Ventura
Abdominal aortic aneurysm (AAA) evolution is unpredictable and no specific treatment exists for AAA, except surgery to prevent aortic rupture. Galectin-3 has been previously associated with CVD, but its potential role in AAA has not been addressed. Galectin-3 levels were increased in the plasma of AAA patients (n=225) compared with the control group (n=100). In addition, galectin-3 concentrations were associated with the need for surgical repair, independently of potential confounding factors. Galectin-3 mRNA and protein expression were increased in human AAA samples compared with healthy aortas...
November 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29079639/immune-checkpoint-inhibitors-in-renal-cell-carcinoma
#19
REVIEW
Kirsty Ross, Rob J Jones
The immune system has long been known to play a critical role in the body's defence against cancer, and there have been multiple attempts to harness it for therapeutic gain. Renal cancer was, historically, one of a small number of tumour types where immune manipulation had been shown to be effective. The current generation of immune checkpoint inhibitors are rapidly entering into routine clinical practice in the management of a number of tumour types, including renal cancer, where one drug, nivolumab, an anti-programmed death-1 (PD-1) monoclonal antibody (mAb), is licensed for patients who have progressed on prior systemic treatment...
November 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29070521/diminished-stress-resistance-and-defective-adaptive-homeostasis-in-age-related-diseases
#20
REVIEW
Naomi Lomeli, Daniela A Bota, Kelvin J A Davies
Adaptive homeostasis is defined as the transient expansion or contraction of the homeostatic range following exposure to subtoxic, non-damaging, signaling molecules or events, or the removal or cessation of such molecules or events (Mol. Aspects Med. (2016) 49, 1-7). Adaptive homeostasis allows us to transiently adapt (and then de-adapt) to fluctuating levels of internal and external stressors. The ability to cope with transient changes in internal and external environmental stress, however, diminishes with age...
November 1, 2017: Clinical Science (1979-)
journal
journal
27660
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"