journal
MENU ▼
Read by QxMD icon Read
search

Neurotoxicology

journal
https://www.readbyqxmd.com/read/28919516/time-dependent-effects-of-perfluorinated-compounds-on-viability-in-cerebellar-granule-neurons-dependence-on-carbon-chain-length-and-functional-group-attached
#1
Hanne Friis Berntsen, Cesilie Granum Bjørklund, Jean-Nicolas Audinot, Tim Hofer, Steven Verhaegen, Esther Lentzen, Arno Christian Gutleb, Erik Ropstad
The toxicity of long chained perfluoroalkyl acids (PFAAs) has previously been reported to be related to the length of the perfluorinated carbon chain and functional group attached. In the present study, we compared the cytotoxicity of six PFAAs, using primary cultures of rat cerebellar granule neurons (CGNs). Two perfluoroalkyl sulfonic acids (PFSAs, chain length C6 and C8) and four perfluoroalkyl carboxylic acids (PFCAs, chain length C8-C11) were studied. These PFAAs have been detected in human blood and the brain tissue of mammals...
September 14, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28919515/trace-amine-associated-receptor-1-regulation-of-methamphetamine-induced-neurotoxicity
#2
Nicholas B Miner, Josh S Elmore, Michael H Baumann, Tamara J Phillips, Aaron Janowsky
Trace amine-associated receptor 1 (TAAR1) is activated by methamphetamine (MA) and modulates dopaminergic (DA) function. Although DA dysregulation is the hallmark of MA-induced neurotoxicity leading to behavioral and cognitive deficits, the intermediary role of TAAR1 has yet to be characterized. To investigate TAAR1 regulation of MA-induced neurotoxicity, Taar1 transgenic knock-out (KO) and wildtype (WT) mice were administered saline or a neurotoxic regimen of 4 i.p. injections, 2hr apart, of MA (2.5, 5, or 10mg/kg)...
September 14, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28917719/polymorphisms-in-manganese-transporters-show-developmental-stage-and-sex-specific-associations-with-manganese-concentrations-in-primary-teeth
#3
Karin Wahlberg, Manish Arora, Austen Curtin, Paul Curtin, Robert O Wright, Donald R Smith, Roberto G Lucchini, Karin Broberg, Christine Austin
BACKGROUND: Manganese (Mn) is an essential metal that can become neurotoxic at elevated levels with negative consequences on neurodevelopment. We have evaluated the influence of single nucleotide polymorphisms (SNPs) in Mn transporter genes SLC30A10 and SLC39A8 on Mn concentrations in dentine, a validated biomarker that reflects Mn tissue concentrations early in life. METHODS: The study included 195 children with variable environmental Mn exposure. Mn concentrations in dentine representing fetal, early postnatal and early childhood developmental periods were measured using laser ablation-inductively coupled plasma mass spectrometry...
September 13, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28917718/olfactory-toxicity-in-rats-following-manganese-chloride-nasal-instillation-a-pilot-study
#4
Melanie L Foster, Deepa B Rao, Taylor Francher, Samantha Traver, David C Dorman
Following inhalation, manganese travels along the olfactory nerve from the olfactory epithelium (OE) to the olfactory bulb (OB). Occupational exposure to inhaled manganese is associated with changes in olfactory function. This pilot study evaluated two related hypotheses: (a) intranasal manganese administration increases OE and OB manganese concentrations; and (b) intranasal manganese exposure impairs performance of previously trained rats on a go-no-go olfactory discrimination (OD) task. Male Fischer 344 rats were trained to either lever press ("go") in response to a positive conditioned stimulus (CS+: vanillin) or to do nothing ("no go") when a negative conditioned stimulus (CS-: amyl acetate) was present...
September 13, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28890130/effects-of-perinatal-bisphenol-a-exposure-on-the-volume-of-sexually-dimorphic-nuclei-of-juvenile-rats-a-clarity-bpa-consortium-study
#5
Sheryl E Arambula, Joelle Fuchs, Jinyan Cao, Heather B Patisaul
Bisphenol A (BPA) is a high volume endocrine disrupting chemical found in a wide variety of products including plastics and epoxy resins. Human exposure is nearly ubiquitous, and higher in children than adults. Because BPA has been reported to interfere with sex steroid hormone signaling, there is concern that developmental exposure, even at levels below the current FDA No Observed Adverse Effect Level (NOAEL) of 5mg/kg body weight (bw)/day, can disrupt brain sexual differentiation. The current studies were conducted as part of the CLARITY-BPA (Consortium Linking Academic and Regulatory Insights on BPA Toxicity) program and tested the hypothesis that perinatal BPA exposure would induce morphological changes in hormone sensitive, sexually dimorphic brain regions...
September 7, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28888663/impact-of-air-manganese-on-child-neurodevelopment-in-east-liverpool-ohio
#6
Erin N Haynes, Heidi Sucharew, Timothy J Hilbert, Pierce Kuhnell, Alonzo Spencer, Nicholas C Newman, Roxanne Burns, Robert Wright, Patrick J Parsons, Kim N Dietrich
BACKGROUND: East Liverpool, Ohio, the site of a hazardous waste incinerator and a manganese (Mn) processor, has had air Mn concentrations exceeding United States Environmental Protection Agency reference levels for over a decade. Save Our County, Inc., a community organization, was formed to address community environmental health concerns related to local industry. Researchers from the University of Cincinnati partnered with Save Our County to determine if air Mn had an impact on the neurocognitive function of children in the community...
September 6, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28855111/behavioral-intoxication-following-voluntary-oral-ingestion-of-tetramethylenedisulfotetramine-dose-dependent-onset-severity-survival-and-recovery
#7
Nathaniel C Rice, Noah A Rauscher, Jeffrey L Langston, Todd M Myers
Tetramethylenedisulfotetramine (tetramine, or TETS) is a highly toxic rodenticide that has been responsible for over 14,000 accidental and intentional poisonings worldwide. Although the vast majority of TETS poisonings involved tainted food or drink, the laboratory in vivo studies of TETS intoxication used intraperitoneal injection or gavage for TETS exposure. Seeking to develop and characterize a more realistic model of TETS intoxication in the present study, rats were trained to rapidly and voluntarily consume a poisoned food morsel...
September 6, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28873337/thalamic-gaba-levels-and-occupational-manganese-neurotoxicity-association-with-exposure-levels-and-brain-mri
#8
Ruoyun E Ma, Eric J Ward, Chien-Lin Yeh, Sandy Snyder, Zaiyang Long, Fulya Gokalp Yavuz, S Elizabeth Zauber, Ulrike Dydak
Excessive occupational exposure to Manganese (Mn) has been associated with clinical symptoms resembling idiopathic Parkinson's disease (IPD), impairing cognitive and motor functions. Several studies point towards an involvement of the brain neurotransmitter system in Mn intoxication, which is hypothesized to be disturbed prior to onset of symptoms. Edited Magnetic Resonance Spectroscopy (MRS) offers the unique possibility to measure γ-amminobutyric acid (GABA) and other neurometabolites in vivo non-invasively in workers exposed to Mn...
September 2, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28870866/evaluation-of-the-effect-of-an-environmental-management-program-on-exposure-to-manganese-in-a-mining-zone-in-mexico
#9
Marlene Cortez-Lugo, Hortensia Moreno Macías, Sergio Montes, Yaneth Rodríguez Agudelo, David Hernández Bonilla, Minerva Catalán-Vázquez, Raúl Díaz Godoy, Sandra Leticia Rodríguez Dozal
BACKGROUND: In the state of Hidalgo, Mexico, is found the largest second deposit of Manganese (Mn) in Latin America. Various studies on the sources of emission, exposure, and the effects on the health of children and adults have been conducted utilizing an ecosystem approach. Given the findings of Mn levels in air and the neurocognitive effects, an Environmental Management Program (EMP) was designed and implemented with the purpose of reducing exposure to Mn of the population, including various actions for reducing Mn emissions into the atmosphere...
September 1, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28870865/changes-in-water-manganese-levels-and-longitudinal-assessment-of-intellectual-function-in-children-exposed-through-drinking-water
#10
Laurie-Anne Dion, Dave Saint-Amour, Sébastien Sauvé, Benoit Barbeau, Donna Mergler, Maryse F Bouchard
BACKGROUND: Manganese is commonly found in water but potential neurotoxic effects from exposure through drinking water are poorly understood. We previously reported a cross-sectional study showing that drinking water Mn concentration was associated with lower IQ in children aged 6 to 13 years. OBJECTIVE: For this follow-up study, we aimed to re-assess the relation between exposure to Mn from drinking water and IQ at adolescence. In addition, we aimed to examine whether changes in drinking water Mn concentration was associated with changes in IQ scores...
September 1, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28867366/assessment-of-saliva-hair-and-toenails-as-biomarkers-of-low-level-exposure-to-manganese-from-drinking-water-in-children
#11
Ruth Ntihabose, Céline Surette, Delphine Foucher, Olivier Clarisse, Maryse F Bouchard
We evaluated hair, toenails, and saliva (whole and supernatant) as biomarkers of exposure to manganese (Mn) in 274 school age children (6-13 years) consuming well water in southeastern New Brunswick, Canada. Mn concentrations in tap water ranged from <0.03 to 1046μgL(-1) (geometric mean 5.96μgL(-1)). The geometric mean of Mn intake resulting from the consumption of water was 0.25 (0-34.95) μg kg(-1)day(-1). Both Mn concentration in water and Mn intake were significantly correlated with Mn in hair (r=0...
September 1, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28866072/changes-in-the-cannabinoids-receptors-in-rats-following-treatment-with-antidepressants
#12
Irena Smaga, Magdalena Zaniewska, Dawid Gawliński, Agata Faron-Górecka, Przemysław Szafrański, Marek Cegła, Małgorzata Filip
The endocannabinoid (eCB) system plays a significant role in the pathophysiology of depression. The potential participation of this system in the mechanism of action of antidepressants has been highlighted in recent years. The aim of this study was to investigate the expression of cannabinoid (CB) receptors using Western blot and CB1 receptor density using autoradiography after acute or chronic administration of antidepressant drugs [imipramine (IMI, 15mg/kg), escitalopram (ESC, 10mg/kg) and tianeptine (TIA, 10mg/kg)]...
September 1, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28866071/neuropathological-and-behavioral-sequelae-in-il-1r1-and-il-1ra-gene-knockout-mice-after-soman-gd-exposure
#13
Teresa M Ferrara-Bowens, Jessica K Chandler, Michelle A Guignet, James F Irwin, Kevin Laitipaya, Devin D Palmer, Lukas J Shumway, Laura B Tucker, Joseph T McCabe, Matthew D Wegner, Erik A Johnson
Soman (GD) exposure results in status epilepticus (SE) that leads to neurodegeneration, neuroinflammation, and behavioral consequences including learning and memory deficits. The neuroinflammatory response is characterized by the upregulation of the pro-inflammatory cytokine, interleukin-1 (IL-1), which mediates the expression of other neurotoxic cytokines induced after GD exposure. However, the specific role of IL-1 signaling has not been defined in terms of the consequences of GD-induced SE. Therefore, the purpose of this study was to regulate IL-1 signaling and study the behavioral deficits and neurodegeneration that occur after convulsion onset...
September 1, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28847517/association-of-exposure-to-manganese-and-iron-with-relaxation-rates-r1-and-r2-magnetic-resonance-imaging-results-from-the-weldox-ii-study
#14
Beate Pesch, Ulrike Dydak, Anne Lotz, Swaantje Casjens, Clara Quetscher, Martin Lehnert, Jessica Abramowski, Christoph Stewig, Chien-Lin Yeh, Tobias Weiss, Christoph van Thriel, Lennard Herrmann, Siegfried Muhlack, Dirk Woitalla, Benjamin Glaubitz, Tobias Schmidt-Wilcke, Thomas Brüning
OBJECTIVE: Magnetic resonance imaging is a non-invasive method that allows the indirect quantification of manganese (Mn) and iron (Fe) accumulation in the brain due to their paramagnetic features. The WELDOX II study aimed to explore the influence of airborne and systemic exposure to Mn and Fe on the brain deposition using the relaxation rates R1 and R2* as biomarkers of metal accumulation in regions of interest in 161 men, including active and former welders. MATERIAL AND METHODS: We obtained data on the relaxation rates R1 and R2* in regions that included structures within the globus pallidus (GP), substantia nigra (SN), and white matter of the frontal lobe (FL) of both hemispheres, as well as Mn in whole blood (MnB), and serum ferritin (SF)...
August 25, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28844784/dieldrin-induced-neurotoxicity-involves-impaired-mitochondrial-bioenergetics-and-an-endoplasmic-reticulum-stress-response-in-rat-dopaminergic-cells
#15
Jordan T Schmidt, Anna Rushin, Jonna Boyda, Christopher Laurence Souders, Christopher J Martyniuk
Mitochondria are sensitive targets of environmental chemicals. Dieldrin (DLD) is an organochlorine pesticide that remains a human health concern due to high lipid bioaccumulation, and it has been epidemiologically associated to an increased risk for Parkinson's disease (PD). As mitochondrial dysfunction is involved in the etiology of PD, this study aimed to determine whether DLD impaired mitochondrial bioenergetics in dopaminergic cells. Rat immortalized dopaminergic N27 cells were treated for 24 or 48h with one dose of either a solvent control, 2...
August 24, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28826884/reduced-expression-of-park2-in-manganese-exposed-smelting-workers
#16
Ximin Fan, Ying Luo, Qiyuan Fan, Wei Zheng
Manganese (Mn) is widely used in modern industries. Occupational exposure to Mn is known to cause clinical syndromes similar, but not identical to, Parkinson's disease. This human cohort study was designed to investigate if workers exposed to Mn altered the PARK2 gene expression, leading to Mn-induced neurotoxicity. Workers (n=26) occupationally exposed to Mn were recruited from a Mn-iron (Fe) alloy smelter, and control workers (n=20) without Mn-exposure were from an Fe smelter from Zunyi City in China. Subjects were matched with socioeconomic status and background for environmental factors...
August 18, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28811174/subchronic-exposure-to-sublethal-dose-of-imidacloprid-changes-electrophysiological-properties-and-expression-pattern-of-nicotinic-acetylcholine-receptor-subtypes-in-insect-neurosecretory-cells
#17
Yassine Benzidane, Delphine Goven, Aly Ahmed Abd-Ella, Caroline Deshayes, Bruno Lapied, Valérie Raymond
Neonicotinoids are the most important class of insecticides used in agriculture over the last decade. They act as selective agonists of insect nicotinic acetylcholine receptors (nAChRs). The emergence of insect resistance to these insecticides is one of the major problems, which limit the use of neonicotinoids. The aim of our study is to better understand physiological changes appearing after subchronic exposure to sublethal doses of insecticide using complementary approaches that include toxicology, electrophysiology, molecular biology and calcium imaging...
August 12, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28811173/prenatal-exposure-to-pyrethroid-pesticides-and-childhood-behavior-and-executive-functioning
#18
Melissa A Furlong, Dana Boyd Barr, Mary S Wolff, Stephanie M Engel
Several previous studies of pyrethroid biomarkers and behavior have reported associations between concurrent pyrethroid levels and adverse behavioral problems in children. One geospatial study reported associations between prenatal exposure to pyrethroids and autism. However, the association between prenatal pyrethroid biomarkers and childhood behavior is unknown. The Mount Sinai Children's Environmental Health Center is a prospective birth cohort with urinary pyrethroid biomarkers during pregnancy and behavioral measurements at 4, 6, and 7-9 years of age...
August 12, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28803850/association-of-exposure-to-manganese-and-iron-with-striatal-and-thalamic-gaba-and-other-neurometabolites-neuroimaging-results-from-the-weldox-ii-study
#19
Swaantje Casjens, Urike Dydak, Shalmali Dharmadhikari, Anne Lotz, Martin Lehnert, Clara Quetscher, Christoph Stewig, Benjamin Glaubitz, Tobias Schmidt-Wilcke, David Edmondson, Chien-Lin Yeh, Tobias Weiss, Christoph van Thriel, Lennard Herrmann, Siegfried Muhlack, Dirk Woitalla, Michael Aschner, Thomas Brüning, Beate Pesch
OBJECTIVE: Magnetic resonance spectroscopy (MRS) is a non-invasive method to quantify neurometabolite concentrations in the brain. Within the framework of the WELDOX II study, we investigated the association of exposure to manganese (Mn) and iron (Fe) with γ-aminobutyric acid (GABA) and other neurometabolites in the striatum and thalamus of 154 men. MATERIAL AND METHODS: GABA-edited and short echo-time MRS at 3T was used to assess brain levels of GABA, glutamate, total creatine (tCr) and other neurometabolites...
August 11, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28803851/manganese-and-neurobehavioral-impairment-a-preliminary-risk-assessment
#20
Robert M Park, Shannon L Berg
Similar patterns of cognitive and motor deficits have been widely reported from manganese exposures in welding, metallurgical and chemical industry workers. A risk assessment was performed based on studies reported in the literature, extending some earlier work, and deriving new estimates of exposure response and excess risk. Many investigations of manganese neurological effects in humans have insufficient information to derive an exposure response; however, findings from a chemical manufacturer, two smelter and two welder populations permitted application of the benchmark dose procedure for continuous end-points...
August 10, 2017: Neurotoxicology
journal
journal
27654
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"