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Journal of Neuroscience Methods

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https://www.readbyqxmd.com/read/28923686/high-speed-video-analysis-improves-the-accuracy-of-spinal-cord-compression-measurement-in-a-mouse-contusion-model
#1
Marion Fournely, Yvan Petit, Éric Wagnac, Jérôme Laurin, Virginie Callot, Pierre-Jean Arnoux
BACKGROUND: Animal models of spinal cord injuries aim to utilize controlled and reproducible conditions. However, a literature review reveals that mouse contusion studies using equivalent protocols may show large disparities in the observed impact force vs. cord compression relationship. The overall purpose of this study was to investigate possible sources of bias in these measurements. The specific objective was to improve spinal cord compression measurements using a video-based setup to detect the impactor-spinal cord time-to-contact...
September 15, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28917660/stereotaxic-18-f-fdg-pet-and-mri-templates-with-three-dimensional-digital-atlas-for-statistical-parametric-mapping-analysis-of-tree-shrew-brain
#2
Qi Huang, Binbin Nie, Chen Ma, Jing Wang, Tianhao Zhang, Shaofeng Duan, Shang Wu, Shengxiang Liang, Panlong Li, Hua Liu, Hua Sun, Jiangning Zhou, Lin Xu, Baoci Shan
BACKGROUND: Tree shrews are proposed as an alternative animal model to nonhuman primates due to their close affinity to primates. Neuroimaging techniques are widely used to study brain functions and structures of humans and animals. However, tree shrews are rarely applied in neuroimaging field partly due to the lack of available species specific analysis methods. NEW METHOD: In this study, 10 PET/CT and 10 MRI images of tree shrew brain were used to construct PET and MRI templates; based on histological atlas we reconstructed a three-dimensional digital atlas with 628 structures delineated; then the digital atlas and templates were aligned into a stereotaxic space...
September 13, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28917659/sonification-of-scalp-recorded-frequency-following-responses-ffrs-offers-improved-response-detection-over-conventional-statistical-metrics
#3
Gavin M Bidelman
BACKGROUND: The human frequency-following response (FFR) is a neurophonic potential used to examine the brain's encoding of complex sounds (e.g., speech) and monitor neuroplastic changes in auditory processing. Given the FFR's low amplitude (order of nanovolts), current conventions in literature recommend collecting several thousand trials to obtain a robust evoked response with adequate signal-to-noise ratio. NEW METHOD: By exploiting the spectrotemporal fidelity of the response, we examined whether auditory playbacks (i...
September 13, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28917658/multiple-events-of-gene-manipulation-via-in-pouch-electroporation-in-a-marsupial-model-of-mammalian-forebrain-development
#4
Annalisa Paolino, Laura R Fenlon, Peter Kozulin, Linda J Richards, Rodrigo Suárez
BACKGROUND: The technique of in utero electroporation has been widely used in eutherians, such as mice and rats, to investigate brain development by selectively manipulating gene expression in specific neuronal populations. A major challenge, however, is that surgery is required to access the embryos, affecting animal survival and limiting the number of times it can be performed within the same litter. New method: Marsupials are born at an early stage of brain development as compared to eutherians...
September 13, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28911857/new-mouse-model-for-inducing-and-evaluating-unilateral-vestibular-deafferentation-syndrome
#5
R Cassel, P Bordiga, D Pericat, C Hautefort, B Tighilet, C Chabbert
BACKGROUND: Unilateral vestibular deafferentation syndrome (uVDS) holds a particular place in the vestibular pathology domain. Due to its suddenness, the violence of its symptoms that often result in emergency hospitalization, and its associated original neurophysiological properties, this syndrome is a major source of questioning for the otoneurology community. Also, its putative pathogenic causes remain to be determined. There is currently a strong medical need for the development of targeted and effective countermeasures to improve the therapeutic management of uVDS...
September 11, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28899650/micropatterned-surface-electrode-for-massive-selective-stimulation-of-intraepidermal-nociceptive-fibres
#6
REVIEW
Massimo Leandri, Lucio Marinelli, Antonio Siri, Luca Pellegrino
BACKGROUND: No satisfactory neurophysiological test for nociceptive afferents is available to date. Laser stimuli present risks of skin damage, whilst electrical stimulation through specially designed electrodes is not selective enough. NEW METHOD: We present a new electrode designed according to critical issues identified in preliminary computer simulations concerning electric field gradient through the skin. To provide selective stimulation the activating electric field must be limited to intraepidermal free nerve endings...
September 9, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28887132/structure-and-diversity-of-human-dendritic-spines-evidenced-by-a-new-three-dimensional-reconstruction-procedure-for-golgi-staining-and-light-microscopy
#7
Roman Reberger, Aline Dall'Oglio, Claudio R Jung, Alberto A Rasia-Filho
BACKGROUND: Different approaches aim to unravel detailed morphological features of neural cells. Dendritic spines are multifunctional units that reflect cellular connectivity, synaptic strength and plasticity. NEW METHOD: A novel three-dimensional (3D) reconstruction procedure is introduced for visualization of dendritic spines from human postmortem brain tissue using brightfield microscopy. The segmentation model was based on thresholding the intensity values of the dendrite spine image along 'z' stacks...
September 5, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28864083/an-operant-based-detection-method-for-inferring-tinnitus-in-mice
#8
Hongyan Zuo, Debin Lei, Shobhana Sivaramakrishnan, Benjamin Howie, Jessica Mulvany, Jianxin Bao
BACKGROUND: Subjective tinnitus is a hearing disorder in which a person perceives sound when no external sound is present. It can be acute or chronic. Because our current understanding of its pathology is incomplete, no effective cures have yet been established. Mouse models are useful for studying the pathophysiology of tinnitus as well as for developing therapeutic treatments. NEW METHOD: We have developed a new method for determining acute and chronic tinnitus in mice, called sound-based avoidance detection (SBAD)...
August 31, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28843679/phase-coherence-classification-a-new-wavelet-based-method-to-separate-local-field-potentials-into-local-in-coherent-and-volume-conducted-components
#9
M von Papen, H Dafsari, E Florin, F Gerick, L Timmermann, J Saur
BACKGROUND: Local field potentials (LFP) reflect the integrated electrophysiological activity of large neuron populations and may thus reflect the dynamics of spatially and functionally different networks. NEW METHOD: We introduce the wavelet-based phase-coherence classification (PCC), which separates LFP into volume-conducted, local incoherent and local coherent components. It allows to compute power spectral densities for each component associated with local or remote electrophysiological activity...
August 31, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28865986/validation-of-salivary-oxytocin-and-vasopressin-as-biomarkers-in-domestic-dogs
#10
Evan L MacLean, Laurence R Gesquiere, Nancy Gee, Kerinne Levy, W Lance Martin, C Sue Carter
BACKGROUND: Oxytocin (OT) and Vasopressin (AVP) are phylogenetically conserved neuropeptides with effects on social behavior, cognition and stress responses. Although OT and AVP are most commonly measured in blood, urine and cerebrospinal fluid (CSF), these approaches present an array of challenges including concerns related to the invasiveness of sample collection, the potential for matrix interference in immunoassays, and whether samples can be collected at precise time points to assess event-linked endocrine responses...
August 30, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28865985/extended-continuous-measures-of-functional-status-in-community-dwelling-persons-with-alzheimer-s-and-related-dementia-infrastructure-performance-tradeoffs-preliminary-data-and-promise
#11
Bradley Zylstra, George Netscher, Julien Jacquemot, Michael Schaffer, Galen Shen, Angela D Bowhay, Tamara L Braley, Katherine L Possin, Bruce L Miller, Alexandre M Bayen, A Katrin Schenk, Stephen J Bonasera
BACKGROUND: The past decades have seen phenomenal growth in the availability of inexpensive and powerful personal computing devices. Efforts to leverage these devices to improve health care outcomes promise to remake many aspects of healthcare delivery, but remain in their infancy. NEW METHOD: We describe the development of a mobile health platform designed for daily measures of functional status in ambulatory, community dwelling subjects, including those who have Alzheimer's disease or related neurodegenerative disorders...
August 30, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28860079/automated-touch-sensing-in-the-mouse-tapered-beam-test-using-raspberry-pi
#12
Dirk Jan Ardesch, Matilde Balbi, Timothy H Murphy
BACKGROUND: Rodent models of neurological disease such as stroke are often characterized by motor deficits. One of the tests that are used to assess these motor deficits is the tapered beam test, which provides a sensitive measure of bilateral motor function based on foot faults (slips) made by a rodent traversing a gradually narrowing beam. However, manual frame-by-frame scoring of video recordings is necessary to obtain test results, which is time-consuming and prone to human rater bias...
August 30, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28860078/removing-eye-blink-artefacts-from-eeg-a-single-channel-physiology-based-method
#13
Shenghuan Zhang, Julia McIntosh, Shabah M Shadli, Phoebe S-H Neo, Zhiyi Huang, Neil McNaughton
BACKGROUND: EEG signals are often contaminated with artefacts, particularly with large signals generated by eye blinks. Deletion of artefact can lose valuable data. Current methods of removing the eye blink component to leave residual EEG, such as blind source component removal, require multichannel recording, are computationally intensive, and can alter the original EEG signal. NEW METHOD: Here we describe a novel single-channel method using a model based on the ballistic physiological components of the eye blink...
August 30, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28860077/the-cs-algorithm-a-novel-method-for-high-frequency-oscillation-detection-in-eeg
#14
Jan Cimbálník, Angela Hewitt, Greg Worrell, Matt Stead
BACKGROUND: High frequency oscillations (HFOs) are emerging as potentially clinically important biomarkers for localizing seizure generating regions in epileptic brain. These events, however, are too frequent, and occur on too small a time scale to be identified quickly or reliably by human reviewers. Many of the deficiencies of the HFO detection algorithms published to date are addressed by the CS algorithm presented here. NEW METHOD: The algorithm employs novel methods for: 1) normalization; 2) storage of parameters to model human expertise; 3) differentiating highly localized oscillations from filtering phenomena; and 4) defining temporal extents of detected events...
August 28, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28851513/flavoprotein-fluorescence-imaging-based-electrode-implantation-for-subfield-targeted-chronic-recording-in-the-mouse-auditory-cortex
#15
Jun Nishikawa, Yuto Ohtaka, Yuishi Tachibana, Yasutaka Yanagawa, Hisayuki Osanai, Takeaki Haga, Takashi Tateno
BACKGROUND: Chronic neural recording in freely moving animals is important for understanding neural activities of cortical neurons associated with various behavioral contexts. In small animals such as mice, it has been difficult to implant recording electrodes into exact locations according to stereotactic coordinates, skull geometry, or the shape of blood vessels. The main reason for this difficulty is large individual differences in the exact location of the targeted brain area. NEW METHODS: We propose a new electrode implantation procedure that is combined with transcranial flavoprotein fluorescence imaging...
August 26, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28837816/identification-and-segmentation-of-myelinated-nerve-fibers-in-a-cross-sectional-optical-microscopic-image-using-a-deep-learning-model
#16
Tatsuhiko Naito, Yu Nagashima, Kenichiro Taira, Naohiro Uchio, Shoji Tsuji, Jun Shimizu
BACKGROUND: The morphometric analysis of myelinated nerve fibers of peripheral nerves in cross-sectional optical microscopic images is valuable. Several automated methods for nerve fiber identification and segmentation have been reported. This paper presents a new method that uses a deep learning model of a convolutional neural network (CNN). We tested it for human sural nerve biopsy images. METHODS: The method comprises four steps: normalization, clustering segmentation, myelinated nerve fiber identification, and clump splitting...
August 26, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28847697/proximity-as-a-predictor-of-social-behavior-in-rats
#17
Rafael Bonuti, Sílvio Morato
BACKGROUND: In studies that measure social behavior of a freely interacting pair rats social behavior of one rat is strongly influenced by the behavior of the other. This prevents evaluating social behavior of one single rat. NEW METHOD: We assessed the motivation to interact socially in a modified open-field, by measuring the time a rat attempted to interact with a co-specific separated by a grid in a birdcage outside of the apparatus. We propose time in front of the birdcage is an indicator of social behavior...
August 25, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28842194/development-of-a-head-mounted-wireless-microstimulator-for-deep-brain-stimulation-in-rats
#18
Felix Fluri, Thomas Mützel, Michael K Schuhmann, Miloš Krstić, Heinz Endres, Jens Volkmann
BACKGROUND: Commercial neurostimulators for clinical use are effective in patients; however they are too large and prohibitively expensive for preclinical studies. Thus, there is an urgent need of a small inexpensive and wireless microstimulator which is fully programmable in frequency, pulse width and amplitude for rodent experiments. NEW METHODS: Rats were subjected to a photothrombotic stroke of the right sensorimotor cortex and a microelectrode was implanted in the right mesencephalic locomotor region...
August 24, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28842191/removal-of-bcg-artefact-from-concurrent-fmri-eeg-recordings-based-on-emd-and-pca
#19
Ehtasham Javed, Ibrahima Faye, Aamir Saeed Malik, Jafri Malin Abdullah
BACKGROUND: Simultaneous electroencephalography (EEG) and functional magnetic resonance image (fMRI) acquisitions provide better insight into brain dynamics. Some artefacts due to simultaneous acquisition pose a threat to the quality of the data. One such problematic artefact is the ballistocardiogram (BCG) artefact. METHODS: We developed a hybrid algorithm that combines features of empirical mode decomposition (EMD) with principal component analysis (PCA) to reduce the BCG artefact...
August 24, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28842193/flow-characterization-and-patch-clamp-dose-responses-using-jet-microfluidics-in-a-tubeless-microfluidic-device
#20
Pedro J Resto, Abhishek Bhat, Eric Stava, Chong Lor, Elliot Merriam, Ruben E Diaz-Rivera, Robert Pearce, Robert Blick, Justin C Williams
BACKGROUND: Surface tension passive pumping is a way to actuate flow without the need for pumps, tubing or valves by using the pressure inside small drop to move liquid via a microfluidic channel. These types of tubeless devices have typically been used in cell biology. Herein we present the use of tubeless devices as a fluid exchange platform for patch clamp electrophysiology. NEW METHOD: Inertia from high-speed droplets and jets is used to create flow and perform on-the-fly mixing of solutions...
August 23, 2017: Journal of Neuroscience Methods
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