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Journal of Neuroscience Methods

Pekka Hautasaari, Urho M Kujala, Ina M Tarkka
BACKGROUND: Deviant stimuli within a standard, frequent stimulus train induce a cortical somatosensory mismatch response (SMMR). The SMMR reflects the brain's automatic mechanism for the detection of change in a somatosensory domain. It is usually elicited by electrical stimulation, which activates nerve fibers and receptors in superficial and deep skin layers, whereas tactile stimulation is closer to natural stimulation and activates uniform fiber types. We recorded SMMRs after electrical and tactile stimuli...
September 12, 2018: Journal of Neuroscience Methods
Daria La Rocca, Nicolas Zilber, Patrice Abry, Virginie van Wassenhove, Philippe Ciuciu
BACKGROUND: The temporal structure of macroscopic brain activity displays both oscillatory and scale-free dynamics. While the functional relevance of neural oscillations has been largely investigated, both the nature and the role of scale-free dynamics in brain processing have been disputed. NEW METHOD: Here, we offer a novel method to rigorously enrich the characterization of scale-free brain activity using a robust wavelet-based assessment of self-similarity and multifractality...
September 10, 2018: Journal of Neuroscience Methods
Eero Satuvuori, Mario Mulansky, Andreas Daffertshofer, Thomas Kreuz
BACKGROUND: Spike trains of multiple neurons can be analyzed following the summed population (SP) or the labeled line (LL) hypothesis. Responses to external stimuli are generated by a neuronal population as a whole or the individual neurons have encoding capacities of their own. The SPIKE-distance estimated either for a single, pooled spike train over a population or for each neuron separately can serve to quantify these responses. NEW METHOD: For the SP case we compare three algorithms that search for the most discriminative subpopulation over all stimulus pairs...
September 10, 2018: Journal of Neuroscience Methods
Johanna Sigl-Glöckner, Julie Seibt
Sleep is well known to benefit cognitive function. In particular, sleep has been shown to enhance learning and memory in both humans and animals. While the underlying mechanisms are not fully understood, it has been suggested that brain activity during sleep modulates neuronal communication through synaptic plasticity. These insights were mostly gained using electrophysiology to monitor ongoing large scale and single cell activity. While these efforts were instrumental in the characterisation of important network and cellular activity during sleep, several aspects underlying cognition are beyond the reach of this technology...
September 9, 2018: Journal of Neuroscience Methods
Mikhail Milchenko, Abraham Z Snyder, Meghan C Campbell, Joshua L Dowling, Keith M Rich, Lindsey M Brier, Joel S Perlmutter, Scott A Norris
BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus produces variable effects in Parkinson disease. Variation may result from different electrode positions relative to target. Thus, precise electrode localization is crucial when investigating DBS effects. NEW METHOD: We developed a semi-automated method, Electrode Shaft Modeling in CT images (ESM-CT) to reconstruct DBS lead trajectories and contact locations. We evaluated methodological sensitivity to operator-dependent steps, robustness to image resampling, and test-retest replicability...
September 7, 2018: Journal of Neuroscience Methods
Ying Li, Zhijun Yao, Huaxiang Zhang, Bin Hu
BACKGROUND: Optimized abnormalities of individual brain network may allow earlier detection of mild cognitive impairment (MCI) and accurate prediction of its conversion to Alzheimer's disease (AD). Currently, most studies constructed individual networks based on region-to-region correlation without employing multi-region information. In order to develop the potential discriminative power of network and provide supportive evidence for feasibility of individual metabolic network study, we propose a new approach of extracting indirect relation based network features from18 F-FDG PET data...
September 5, 2018: Journal of Neuroscience Methods
Hong-Viet V Ngo, Mitja Seibold, Désirée C Boche, Matthias Mölle, Jan Born
BACKGROUND: The consolidation of sleep-dependent memories is mediated by an interplay of cortical slow oscillations (SOs) and thalamo-cortical sleep spindles. Whereas an enhancement of SOs with auditory closed-loop stimulation has been proven highly successful, the feasibility to induce and boost sleep spindles with auditory stimulation remains unknown thus far. NEW METHOD: Here we tested the possibility to enhance spindle activity during endogenous SOs and thereby to promote memory consolidation...
September 5, 2018: Journal of Neuroscience Methods
Pedro Andrade, Robert Ciszek, Asla Pitkänen, Xavier Ekolle Ndode-Ekane
BACKGROUND: Both the type and severity of functional impairments caused by damage to the cerebral cortex depend on the functional cortical areas and networks affected, as well as the lesion extent and type. NEW METHOD: To accelerate the laborious quantitative analysis of cortical lesion location and size, we created user-friendly software that generates two-dimensional unfolded cortical maps of the lesions in adult rats. The program imports and superimposes simple user-made measurements, e...
September 5, 2018: Journal of Neuroscience Methods
David Y Chung, Kazutaka Sugimoto, Paul Fischer, Maximilian Böhm, Tsubasa Takizawa, Homa Sadeghian, Andreia Morais, Andrea Harriott, Fumiaki Oka, Tao Qin, Nils Henninger, Mohammad A Yaseen, Sava Sakadžić, Cenk Ayata
BACKGROUND: Cortical spreading depolarization (CSD) is a phenomenon classically associated with migraine aura. CSDs have also been implicated in secondary injury following ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and traumatic brain injury; however, most investigations involving these disease processes do not account for the occurrence of CSDs. A major barrier to detection of CSDs in experimental models is that currently validated methods are invasive and require specialized equipment and a high level of expertise to implement...
September 5, 2018: Journal of Neuroscience Methods
S A Helekar, S Convento, L Nguyen, B S John, A Patel, J M Yau, H U Voss
BACKGROUND: Weak or low intensity transcranial stimulation of the brain, such as low field magnetic stimulation and electrical stimulation, can produce significant functional and therapeutic neuromodulatory effects. NEW METHOD: We have recently developed a portable wearable multifocal brain stimulator called transcranial rotating permanent magnet stimulator (TRPMS) that uses rapidly spinning high field strength permanent magnets attached to a cap. It produces oscillatory stimuli of different frequencies and patterns...
September 5, 2018: Journal of Neuroscience Methods
Hans E Anderson, John H Caldwell, Richard F Weir
BACKGROUND: Determination of transgene expression in motor axons of peripheral nerves is important in evaluating the effectiveness of viral transduction. Currently only manual and semi-automatic methods of quantification have been employed for quantification in immunolabeled nerve sections, but automatic methods exist for axon counting only in brightfield sections. Manual and semi-automatic methods can suffer from inter- and intraobserver bias, sampling bias and can be time consuming to implement...
September 4, 2018: Journal of Neuroscience Methods
R B Govindan, A N Massaro, Adre du Plessis
BACKGROUND: Near infrared spectroscopy (NIRS) derived hemoglobin difference (HbD: oxygenated [HbO2] - reduced hemoglobin [Hb]) and total hemoglobin (HbT: HbO2+Hb) have been used as surrogate measures of cerebral blood flow and volume, respectively. Statistically, a lack of HbD-blood pressure (BP) or negative HbT-BP association is regarded as a state of intact cerebral pressure autoregulation (CPA). In contrast, a co-variation of HbD/HbT and systemic blood pressure (BP) in the same direction is thought of as a failure of CPA...
September 4, 2018: Journal of Neuroscience Methods
Bertrand Massot, Sébastien Arthaud, Baptiste Barrillot, Johanna Roux, Gianina Ungurean, Pierre-Hervé Luppi, Niels C Rattenborg, Paul-Antoine Libourel
BACKGROUND: Sleep is an inactive state of reduced environmental awareness shared by all animals. When compared to wakefulness, sleep behavior is associated with changes in physiology and brain activity. The nature of these changes varies considerably across species, and therefore is a rich resource for gaining insight into the evolution and functions of sleep. A major obstacle to capitalizing on this resource is the lack of a small device capable of recording multiple biological parameters for extended periods of time both in the laboratory and the field...
September 3, 2018: Journal of Neuroscience Methods
Ali Moharramipour, Parham Mostame, Gholam-Ali Hossein-Zadeh, James W Wheless, Abbas Babajani-Feremi
BACKGROUND: The effects of statistical testing on the results of multivariate autoregressive (MVAR)-based effective connectivity analysis have not been adequately investigated, and it is still unclear which statistical test can provide the most accurate results. NEW METHODS: Using simulated and real electrocorticographic (ECoG) data, we investigated the performance of three nonparametric statistical tests - Monte Carlo permutation, bootstrap resampling, and surrogate data method in MVAR-based effective connectivity analysis...
September 3, 2018: Journal of Neuroscience Methods
Shi Quan Wong, Alistair Jones, Steven Dodd, Douglas Grimes, Jeff W Barclay, Anthony G Marson, Vincent T Cunliffe, Robert D Burgoyne, Graeme J Sills, Alan Morgan
BACKGROUND: Epilepsy affects around 1% of people, but existing antiepileptic drugs (AEDs) only offer symptomatic relief and are ineffective in approximately 30% of patients. Hence, new AEDs are sorely needed. However, a major bottleneck is the low-throughput nature of early-stage AED screens in conventional rodent models. This process could potentially be expedited by using simpler invertebrate systems, such as the nematode Caenorhabditis elegans. NEW METHOD: Head-bobbing convulsions were previously reported to be inducible by pentylenetetrazol (PTZ) in C...
September 3, 2018: Journal of Neuroscience Methods
Md Ashad Alam, Hui-Yi Lin, Hong-Wen Deng, Vince D Calhoun, Yu-Ping Wang
BACKGROUND: Technological advances are enabling us to collect multimodal datasets at an increasing depth and resolution while with decreasing labors. Understanding complex interactions among multimodal datasets, however, is challenging. NEW METHOD: In this study, we tested the interaction effect of multimodal datasets using a novel method called the kernel machine for detecting higher order interactions among biologically relevant multimodal data. Using a semiparametric method on a reproducing kernel Hilbert space, we formulated the proposed method as a standard mixed-effects linear model and derived a score-based variance component statistic to test higher order interactions between multimodal datasets...
September 2, 2018: Journal of Neuroscience Methods
Owen Lewis, Max Woolley, David Johnson, Julia Fletcher, Johnathan Fenech, Mariusz W Pietrzyk, Neil U Barua, Alison S Bienemann, Will Singleton, Sam L Evans, Steven S Gill
BACKGROUND: The design and use of convection-enhanced delivery catheters remains an active field as clinical trials have highlighted suboptimal distribution as a contributory factor to the failure of those studies. Recent studies indicate limitations and challenges in achieving target coverage using conventional point source delivery. NEW METHOD: The recessed step catheter(RSC), developed by this group, does not function as a point source delivery device, but instead uses 'controlled reflux' of the infusate to a flow inhibiting recess feature...
September 1, 2018: Journal of Neuroscience Methods
Ozkan Cigdem, Hasan Demirel
BACKGROUND: In diagnosis of neurodegenerative diseases, the three-dimensional magnetic resonance imaging (3D-MRI) has been heavily researched. Parkinson's disease (PD) is one of the most common neurodegenerative disorders. NEW METHOD: The performances of five different classification approaches using five different attribute rankings each followed with an adaptive Fisher stopping criteria feature selection (FS) method are evaluated. To improve the performance of PD detection, a source fusion technique which combines the gray matter (GM) and white (WM) tissue maps and a decision fusion technique which combines the outputs of all classifiers using the correlation-based feature selection (CFS) method by majority voting are used...
September 1, 2018: Journal of Neuroscience Methods
Olivier Darbin, Daniel Dees, Markus Lammle, Dean Naritoku, Tatiana Torres-Herman, Anthony Martino
BACKGROUND: Deep brain stimulation is an effective treatment for movement disorders and psychiatric conditions. Intra-operative and post-operative events can result in brain tissue deformation (i.e. subdural gaps) which may cause lead deformation and its displacement from optimal target. We developed a method to quantify postoperative lead deformation and we present two DBS cases to illustrate the phenomena of lead deformation resulting from the development of subdural gaps. NEW METHOD: We present a semi-automatic computational algorithm using Computed Tomography scanning with reconstruction to determine lead curvature relative to a theoretical straight lead between the skull entry site and lead tip...
August 29, 2018: Journal of Neuroscience Methods
Alexander Kazakov, Israel Nelken
BACKGROUND: The sound fed to a loudspeaker may significantly differ from that reaching the ear of the listener. The transformation from one to the other consists of spectral distortions with strong dependence on the relative locations of the speaker and the listener as well as on the geometry of the environment. With the increased importance of research in awake, freely-moving animals in large arenas, it becomes important to understand how animal location influences the corresponding spectral distortions...
August 27, 2018: Journal of Neuroscience Methods
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