Lucy Liang, Isabela Zimmermann Rollin, Aydin Alikaya, Jonathan C Ho, Tales Santini, Andreea C Bostan, Helen N Schwerdt, William R Stauffer, Tamer S Ibrahim, Elvira Pirondini, David J Schaeffer
BACKGROUND: High-precision neurosurgical targeting in nonhuman primates (NHPs) often requires presurgical anatomy mapping with noninvasive neuroimaging techniques (MRI, CT, PET), allowing for translation of individual anatomical coordinates to surgical stereotaxic apparatus. Given the varied tissue contrasts that these imaging techniques produce, precise alignment of imaging-based coordinates to surgical apparatus can be cumbersome. MRI-compatible stereotaxis with radiopaque fiducial markers offer a straight-forward and reliable solution, but existing commercial options do not fit in conformal head coils that maximize imaging quality...
April 6, 2024: Journal of Neuroscience Methods