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Calcified Tissue International

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https://www.readbyqxmd.com/read/27913821/theobromine-upregulates-osteogenesis-by-human-mesenchymal-stem-cells-in-vitro-and-accelerates-bone-development-in-rats
#1
Bret H Clough, Joni Ylostalo, Elizabeth Browder, Eoin P McNeill, Thomas J Bartosh, H Ralph Rawls, Tetsuo Nakamoto, Carl A Gregory
Theobromine (THB) is one of the major xanthine-like alkaloids found in cacao plant and a variety of other foodstuffs such as tea leaves, guarana and cola nuts. Historically, THB and its derivatives have been utilized to treat cardiac and circulatory disorders, drug-induced nephrotoxicity, proteinuria and as an immune-modulator. Our previous work demonstrated that THB has the capacity to improve the formation of hydroxyl-apatite during tooth development, suggesting that it may also enhance skeletal development...
December 2, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27866237/long-term-effects-of-intravenous-ibandronate-in-paget-s-disease-of-bone
#2
Ian R Reid, Diana Wattie, Gregory D Gamble, Ramanamma Kalluru, Tim Cundy
We have previously demonstrated that intravenous ibandronate produces high initial response rates in Paget's disease, but the durability of this effect is unknown. It might be expected to be short lived because ibandronate has a low affinity for bone. Here we report long-term follow-up (up to 14 years) of patients from that trial. Twenty-five patients with active Paget's disease [baseline serum total alkaline phosphatase (ALP) ~3 times the upper limit of normal] received either 6 or 12 mg intravenous ibandronate at baseline...
November 19, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27866236/effects-of-physical-exercise-on-markers-of-cellular-immunosenescence-a-systematic-review
#3
REVIEW
H Cao Dinh, I Beyer, T Mets, O O Onyema, R Njemini, W Renmans, M De Waele, K Jochmans, S Vander Meeren, I Bautmans
Aging affects negatively the immune system, defined as immunosenescence, which increases the susceptibility of elderly persons to infection, autoimmune disease, and cancer. There are strong indications that physical exercise in elderly persons may prevent the age-related decline in immune response without significant side effects. Consequently, exercise is being considered as a safe mode of intervention to reduce immunosenescence. The aim of this review was to appraise the existing evidence regarding the impact of exercise on surface markers of cellular immunosenescence in either young and old humans or animals...
November 19, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27832316/bone-derived-factors-a-new-gateway-to-regulate-glycemia
#4
Nicolas Bonnet
Type 2 diabetes mellitus (T2DM) and osteoporosis are two major disorders which prevalence increases with aging and is predicted to worsen in the coming years. Preclinical investigations suggest common mechanisms implicated in the pathogenesis of both disorders. Recent evidence has established that there is a clear link between glucose and bone metabolism. The emergence of bone as an endocrine regulator through FGF23 and osteocalcin has led to the re-evaluation of the role of bone cells and bone-derived factors in the development of metabolic diseases such as T2DM...
November 10, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27832315/bazedoxifene-ameliorates-homocysteine-induced-apoptosis-and-accumulation-of-advanced-glycation-end-products-by-reducing-oxidative-stress-in-mc3t3-e1-cells
#5
Ippei Kanazawa, Tsutomu Tomita, Shun Miyazaki, Eiji Ozawa, Luis A Yamamoto, Toshitsugu Sugimoto
Elevated plasma homocysteine (Hcy) level increases the risk of osteoporotic fracture by deteriorating bone quality. However, little is known about the effects of Hcy on osteoblast and collagen cross-links. This study aimed to investigate whether Hcy induces apoptosis of osteoblastic MC3T3-E1 cells as well as affects enzymatic and nonenzymatic collagen cross-links and to determine the effects of bazedoxifene, a selective estrogen receptor modulator, on the Hcy-induced apoptosis and deterioration of collagen cross-links in the cells...
November 10, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27832314/diets-high-in-fat-or-fructose-differentially-modulate-bone-health-and-lipid-metabolism
#6
Aditi Jatkar, Irwin J Kurland, Stefan Judex
Diets high in fat or carbohydrates can lead to obesity and diabetes, two interrelated conditions that have been associated with osteoporosis. Here, we contrasted the effects of a high fat (HF) versus fructose-enriched carbohydrate (CH) versus regular chow (SC) diet on bone morphology, fat content and metabolic balance in BALB/cByJ mice over a 15-week period. For 13 weeks, there were no differences in body mass between groups with small differences in the last 2 weeks. Even without the potentially confounding factor of altered body mass and levels of load bearing, HF consumption was detrimental to bone in the distal femur with lower trabecular bone volume fraction and thinner cortices than controls...
November 10, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27830280/erratum-to-reference-values-of-total-lean-mass-appendicular-lean-mass-and-fat-mass-measured-with-dual-energy-x-ray-absorptiometry-in-a-healthy-mexican-population
#7
Patricia Clark, Edgar Denova-Gutiérrez, Regina Ambrosi, Pawel Szulc, Rodolfo Rivas-Ruiz, Jorge Salmerón
No abstract text is available yet for this article.
November 10, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27830279/letter-to-the-editor
#8
LETTER
Patricia Clark, Edgar Denova-Gutiérrez, Regina Ambrosi, Pawel Szulc, Rodolfo Rivas-Ruiz, Jorge Salmerón
No abstract text is available yet for this article.
November 9, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27830278/molecular-communication-from-skeletal-muscle-to-bone-a-review-for-muscle-derived-myokines-regulating-bone-metabolism
#9
REVIEW
Baosheng Guo, Zong-Kang Zhang, Chao Liang, Jie Li, Jin Liu, Aiping Lu, Bao-Ting Zhang, Ge Zhang
Besides the mechanical loading-dependent paradigm, skeletal muscle also serves as an endocrine organ capable of secreting cytokines to modulate bone metabolism. In this review, we focused on reviewing the myokines involved in communication from skeletal muscle to bone, i.e. (1) myostatin and myostatin-binding proteins including follistatin and decorin, (2) interleukins including interleukin-6 (IL-6), interleukin-7 (IL-7) and interleukin-15 (IL-15), (3) insulin-like growth factor 1 (IGF-1) and its binding proteins, (4) other myokines including PGC-1α-irisin system and osteoglycin (OGN)...
November 9, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27826644/novel-faces-of-fibroblast-growth-factor-23-fgf23-iron-deficiency-inflammation-insulin-resistance-left-ventricular-hypertrophy-proteinuria-and-acute-kidney-injury
#10
Mehmet Kanbay, Marc Vervloet, Mario Cozzolino, Dimitrie Siriopol, Adrian Covic, David Goldsmith, Yalcin Solak
FGF23 is a hormone that appears as the core regulator of phosphate metabolism. Great deal of data has accumulated to demonstrate increased FGF23 secretion from the bone to compensate for even subtle increases in serum phosphorus long before intact PTH. However, recent evidence points to the fact that actions and interactions of FGF23 are not limited solely to phosphate metabolism. FGF23 may be implicated in iron metabolism and erythropoiesis, inflammation, insulin resistance, proteinuria, acute kidney injury and left ventricular hypertrophy...
November 9, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27815568/diabetes-drug-effects-on-the-skeleton
#11
Manju Chandran
Diabetes be it type 1 or type 2 is associated with an increased risk of fragility fractures. The mechanisms underlying this increased risk are just being elucidated. Anti-diabetes medications are crucial for maintaining glucose control and for preventing micro- and macrovascular complications in diabetes. However, they may modulate fracture risk in diabetes in different ways. Thiazolidinediones have demonstrated an unfavorable effect on the skeleton, while metformin and sulfonylureas may have a neutral if not beneficial effect on bone...
November 4, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27815567/comment-on-reference-values-of-total-lean-mass-appendicular-lean-mass-and-fat-mass-measured-with-dual-energy-x-ray-absorptiometry-in-a-healthy-mexican-population
#12
LETTER
Eva Amado-Bonilla, Maria I Pintado-Vidal, Maria I Mangas-Borrego, Estefania Marchena-Ortiz, Jorge Barrantes-Chacon, Jose M Moran
No abstract text is available yet for this article.
November 4, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27807601/maternal-dietary-nutrient-intake-during-pregnancy-and-offspring-linear-growth-and-bone-the-vitamin-d-in-pregnancy-cohort-study
#13
Natalie K Hyde, Sharon L Brennan-Olsen, John D Wark, Sarah M Hosking, Julie A Pasco
Magnesium, phosphorus, zinc, calcium, potassium and protein all play integral roles in maintaining bone health in adults; however, less is known about the importance of these minerals in utero. We aimed to determine associations between maternal dietary consumption of these nutrients during gestation and birth measures in offspring. Of 475 pregnant women recruited from a single antenatal clinic before 16-week gestation (2002-2003) as part of the vitamin D in pregnancy study, 346 with recorded maternal dietary intakes at 28- to 32-week gestation and offspring measures at birth were included...
November 2, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27796463/defining-the-properties-of-an-array-of-nh2-modified-substrates-for-the-induction-of-a-mature-osteoblast-osteocyte-phenotype-from-a-primary-human-osteoblast-population-using-controlled-nanotopography-and-surface-chemistry
#14
Sandra A Fawcett, Judith M Curran, Rui Chen, Nicholas P Rhodes, Mark F Murphy, Peter Wilson, Lakshminarayan Ranganath, Jane P Dillon, James A Gallagher, John A Hunt
Accelerating the integration of a joint replacement or the healing of a bone fracture, particularly a complicated non-union fracture, would improve patient welfare and decrease healthcare costs. Currently, an autologous bone graft is the gold standard method for the treatment of complicated non-union fractures, but it is not always possible to harvest such a graft. A proactive highly inductive so-called smart material approach is pertinent in these cases. In this study, the surface chemistry of a previously approved material with desirable bulk material properties was modified to investigate its potential as an economical and effective alternative...
October 28, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27796462/novel-mutations-in-serpinf1-result-in-rare-osteogenesis-imperfecta-type-vi
#15
Jian-Yi Wang, Yi Liu, Li-Jie Song, Fang Lv, Xiao-Jie Xu, A San, Jian Wang, Huan-Ming Yang, Zi-Ying Yang, Yan Jiang, Ou Wang, Wei-Bo Xia, Xiao-Ping Xing, Mei Li
Osteogenesis imperfecta (OI) is a group of inherited disorders characterized by recurrent fragile fractures. Serpin peptidase inhibitor, clade F, member 1 (SERPINF1) is known to cause a distinct, extremely rare autosomal recessive form of type VI OI. Here we report, for the first time, the detection of SERPINF1 mutations in Chinese OI patients. We designed a novel targeted next-generation sequencing panel of OI-related genes to identify pathogenic mutations, which were confirmed with Sanger sequencing and by co-segregation analysis...
October 28, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27771736/unloading-induced-degradation-of-the-anisotropic-arrangement-of-collagen-apatite-in-rat-femurs
#16
Jun Wang, Takuya Ishimoto, Takayoshi Nakano
The specific orientation of collagen and biological apatite (BAp) is an anisotropic feature of bone micro-organization; it is an important determinant of bone mechanical function and performance under anisotropic stress. However, it is poorly understood how this microstructure orientation is altered when the mechanical environment changes. We hypothesized that the preferential orientation of collagen/BAp would change in response to changes in mechanical conditions, similar to the manner in which bone mass and bone shape change...
October 22, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27752731/reduced-protein-expression-of-the-na-ca-2-k-exchanger-slc24a4-in-apical-plasma-membranes-of-maturation-ameloblasts-of-fluorotic-mice
#17
A L J J Bronckers, R Jalali, J Lytton
Exposure of forming enamel to fluoride results into formation of hypomineralized enamel. We tested whether enamel hypomineralization was caused by lower expression of the NCKX4/SLC24A4 Ca(2+)-transporter by ameloblasts. Three commercial antibodies against NCKX4 were tested on enamel organs of wild-type and Nckx4-null mice, one of which (a mouse monoclonal) was specific. This antibody gave a prominent staining of the apical plasma membranes of maturation ameloblasts, starting at early maturation. The layer of immuno-positive ameloblasts contained narrow gaps without immunostaining or with reduced staining...
October 17, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27743017/longitudinal-evaluation-of-bone-mineral-density-and-bone-metabolism-markers-in-patients-with-indolent-systemic-mastocytosis-without-osteoporosis
#18
A Artuso, C Caimmi, G Tripi, O Viapiana, M Bonifacio, L Idolazzi, I Gavioli, D Gatti, R Zanotti, M Rossini
Systemic Mastocytosis has been long identified as a potential cause of osteoporosis; nevertheless, data regarding longitudinal variation of bone mineral density (BMD) in patients with indolent systemic mastocytosis (ISM) are missing . We studied BMD variation at lumbar spine and proximal hip after 30-month (±6 months) follow-up in a large cohort of patients (83) with ISM without osteoporosis, supplementated with vitamin D and/or calcium when needed. We also analyzed the correlation between variation of BMD, basal serum tryptase levels and bone turnover markers (BTM)...
October 14, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27738719/burden-of-first-osteoporotic-hip-fracture-in-spain-a-prospective-12-month-observational-study
#19
Jose Ramón Caeiro, Agustí Bartra, Manuel Mesa-Ramos, Íñigo Etxebarría, Jorge Montejo, Pedro Carpintero, Francesc Sorio, Sonia Gatell, Andrea Farré, Laura Canals
The purpose of this study was to estimate the burden of osteoporotic fractures beyond the hospitalization period covering up to the first year after the fracture. This was a prospective, 12-month, observational study including patients aged ≥65 years hospitalized due to a first low-trauma hip fracture, in six Spanish regions. Health resource utilization (HRU), quality of life (QoL) and autonomy were collected and total costs calculated. Four hundred and eighty seven patients (mean ± SD age 83 ± 7 years, 77 % women) were included...
October 14, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27722770/delineating-the-relationship-between-leptin-fat-mass-and-bone-mineral-density-a-mediation-analysis
#20
Lan T Ho-Pham, Thai Q Lai, Uyen D T Nguyen, Quoc V Bui, Tuan V Nguyen
To test the hypothesis that the relationship between fat mass (FM) and bone mineral density (BMD) is mediated by leptin. The study involved 611 individuals aged 20-89 years who were randomly sampled from Ho Chi Minh City (Vietnam). BMD at the femoral neck (FN), lumbar spine (LS), and whole body (WB) was measured by DXA. Lean mass and FM were derived from the WB DXA scan. Leptin was measured by ELISA (DRG Diagnostics, Germany). The regression method was used to partition the variance of leptin and FM on BMD...
October 8, 2016: Calcified Tissue International
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