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Calcified Tissue International

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https://www.readbyqxmd.com/read/28913616/bone-phenotype-assessed-by-hrpqct-and-associations-with-fracture-risk-in-the-glow-study
#1
A E Litwic, L D Westbury, D E Robinson, K A Ward, C Cooper, E M Dennison
The epidemiology and pathogenesis of fractures in postmenopausal women has previously been investigated in the Global Longitudinal study of Osteoporosis in Women (GLOW). To date, however, relationships between bone imaging outcomes and fracture have not been studied in this cohort. We examined relationships between high-resolution peripheral quantitative computed tomography (HRpQCT) parameters and fracture in the UK arm of GLOW, performing a cluster analysis to assess if our findings were similar to observations reported from older participants of the Hertfordshire Cohort Study (HCS), and extended the analysis to include tibial measurements...
September 14, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28913546/economic-burden-of-osteoporosis-in-south-korea-claim-data-of-the-national-health-insurance-service-from-2008-to-2011
#2
Yong-Chan Ha, Ha-Young Kim, Sunmee Jang, Young-Kyun Lee, Tae-Young Kim
The purpose of this study was to estimate the current economic burden of osteoporosis in South Korea using national claim data of the Korean National Health Insurance Service (KNHIS) from 2008 to 2011. Patients aged 50 years or older were identified from KNHIS nationwide database for all records of outpatient visits or hospital admissions. Healthcare costs for osteoporotic patients included direct medical costs for hospitalization, outpatient care, and prescription drugs for the year after discharge. Healthcare costs were estimated based on the perspective of KNHIS, and calculated using a bottom-up approach...
September 14, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28900676/free-fatty-acid-receptor-4-mediates-the-beneficial-effects-of-n-3-fatty-acids-on-body-composition-in-mice
#3
Han Jin Cho, Seong Hee Ahn, Young-Sun Lee, Seung Hun Lee, Dong-Soon Im, Inki Kim, Jung-Min Koh, Sungsub Kim, Beom-Jun Kim
As populations continue to age worldwide, sarcopenic obesity has heightened interest due to its medical importance. Although much evidence now indicates that n-3 fatty acids (FAs) may have beneficial effects on body composition including fat and muscle, their exact mechanisms have not yet been elucidated. Because free FA receptor 4 (FFA4) has been reported to be a receptor for n-3 FAs, we hypothesized that the protective role of n-3 FAs on body composition could be mediated by FFA4. To test this possibility, we generated mice overexpressing n-3 FAs but lacking FFA4 by crossing fat-1 transgenic (fat-1 (Tg+)) and FFA4 knockout (Ffar4 (-/-)) mice...
September 12, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28900675/bone-disease-in-connective-tissue%C3%A2-disease-systemic-lupus-erythematosus
#4
REVIEW
Irene E M Bultink
This article reviews recent advances in the research of the mechanisms of bone loss, as well as clinical features, economic impact and therapeutic implications of osteoporosis and fractures in patients with systemic lupus erythematosus (SLE) as an illustration of bone disease in a complex systemic autoimmune connective tissue disease. Recent studies demonstrated an increased incidence of osteoporosis and peripheral and vertebral fractures in patients with SLE. The aetiology of bone loss in SLE is multifactorial, including clinical osteoporosis risk factors, systemic inflammation, serological factors, metabolic factors, hormonal factors, possibly genetic factors and medication-induced adverse effects...
September 12, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28884211/the-changing-presentation-of-paget-s-disease-of-bone-in-australia-a-high-prevalence-region
#5
Cameron Britton, Suzanne Brown, Lynley Ward, Sarah L Rea, Thomas Ratajczak, John P Walsh
Studies from several countries suggest that the incidence of Paget's disease of bone (PDB) and the severity of newly diagnosed cases are declining. The aim of this study was to examine secular changes in clinical presentation of PDB in Australia, which historically had the highest prevalence outside the United Kingdom. The participants were 293 patients (61% male) diagnosed between 1956 and 2013 with details recorded in the database of the Paget's Disease Research Group of Western Australia. The mean age at diagnosis was 62 years (range 28-90); 26% of participants had a family history of PDB and 11% had Sequestosome 1 (SQSTM1) mutations...
September 7, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28866763/bone-health-is-maintained-while-fat-mass-is-reduced-in-pre-pubertal-children-with-obesity-participating-in-a-1-year-family-centered-lifestyle-intervention
#6
Tamara R Cohen, Tom J Hazell, Catherine A Vanstone, Celia Rodd, Hope A Weiler
Diet and physical activity (PA) influence bone health in children. This study tested whether increasing milk and milk products and weight-bearing types of PA favorably changed bone outcomes assessed by dual-energy X-ray absorptiometry (DXA) and bone biomarkers in children with obesity participating in a 1-year family-centered lifestyle intervention. Children were randomized to one of three groups: Control (Ctrl; no intervention), Standard treatment (StnTx: two servings milk and milk products/day; meet PA guidelines plus weight-bearing PA three times/week), or Modified treatment (ModTx: four servings milk and milk products/day; meet PA guidelines plus daily weight-bearing PA)...
September 2, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28861648/the-role-of-secondary-calciprotein-particles-in-the-mineralisation-paradox-of-chronic-kidney-disease
#7
Michael M X Cai, Edward R Smith, Sven-Jean Tan, Timothy D Hewitson, Stephen G Holt
Mineralisation paradox is prevalent in chronic kidney disease and ageing where increased vascular calcification is accompanied by reduced bone mineralisation and osteopenia. Secondary calciprotein particles (CPP2), colloidal nanoparticles containing hydroxyapatite crystal stabilised by a protein shell, have been implicated in vascular calcification in chronic kidney disease. Here, we describe the effect of CPP2 on osteoblasts and vascular smooth muscle cells (VSMC) mineralisation in an in vitro model system...
August 31, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28856390/hypogonadal-men-with-higher-body-mass-index-have-higher-bone-density-and-better-bone-quality-but-reduced-muscle-density
#8
Lina E Aguirre, Georgia Colleluori, Richard Dorin, David Robbins, Rui Chen, Bryan Jiang, Clifford Qualls, Dennis T Villareal, Reina Armamento-Villareal
Although hypogonadism is a risk factor for bone loss and fractures, the different etiopathophysiology and hormonal profile of classical and obesity-induced hypogonadism may lead to differences in musculoskeletal profile. This is a cross-sectional study of hypogonadal men between 40 and 74 years old. Our outcomes include: areal bone mineral density (aBMD) and body composition by dual-energy X-ray absorptiometry; volumetric BMD (vBMD) and soft tissue composition of the tibia by peripheral quantitative computed tomography...
August 30, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28840578/bone-mineral-density-is-lower-in-patients-with-severe-knee-osteoarthritis-and-attrition
#9
Karina Nørgaard Linde, Katriina Bøcker Puhakka, Bente Lomholt Langdahl, Kjeld Søballe, Inger Krog-Mikkelsen, Frank Madsen, Maiken Stilling
Bone quality is probably important for the survival of knee arthroplasty (KA), but little is known about systemic bone mineral density and bone turnover in patients prior to KA surgery. The aim of this study was to explore the prevalence of osteoporosis and bone turnover in relation to knee osteoarthritis (OA) grade in patients scheduled for KA surgery. Prospective preoperative evaluation of 450 patients (259 females) prior to KA between 2014 and 2016 with standing knee radiography, Dual-energy X-ray absorptiometry (DXA), biomarkers for bone turnover (CTX, P1NP), and vitamin D...
August 24, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28828511/low-skeletal-muscle-mass-is-associated-with-the-risk-of-low-bone-mineral-density-in-urban-dwelling-premenopausal-women
#10
In Je Kim, Kwi Young Kang
To evaluate the relationship between skeletal muscle mass and bone mineral density (BMD) and to determine the association between low skeletal muscle mass and low BMD in urban dwelling young adults. This study was based on data from the 2008-2011 Korea National Health and Nutrition Examination Surveys. The subjects were 1702 20-49-year-old men and 2192 premenopausal women (age 20-55 years). BMD at the lumbar spine, femoral neck, and total hip and the appendicular skeletal muscle mass (ASM) were measured by dual-energy X-ray absorptiometry...
August 21, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28823001/effects-of-fermented-milk-products-on-bone
#11
REVIEW
René Rizzoli, Emmanuel Biver
Fermented milk products like yogurt or soft cheese provide calcium, phosphorus, and protein. All these nutrients influence bone growth and bone loss. In addition, fermented milk products may contain prebiotics like inulin which may be added to yogurt, and provide probiotics which are capable of modifying intestinal calcium absorption and/or bone metabolism. On the other hand, yogurt consumption may ensure a more regular ingestion of milk products and higher compliance, because of various flavors and sweetness...
August 19, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28795233/bicarbonate-transport-during-enamel-maturation
#12
REVIEW
Kaifeng Yin, Michael L Paine
Amelogenesis (tooth enamel formation) is a biomineralization process consisting primarily of two stages (secretory stage and maturation stage) with unique features. During the secretory stage, the inner epithelium of the enamel organ (i.e., the ameloblast cells) synthesizes and secretes enamel matrix proteins (EMPs) into the enamel space. The protein-rich enamel matrix forms a highly organized architecture in a pH-neutral microenvironment. As amelogenesis transitions to maturation stage, EMPs are degraded and internalized by ameloblasts through endosomal-lysosomal pathways...
August 9, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28779183/does-a-treadmill-running-exercise-contribute-to-preventing-deterioration-of-bone-mineral-density-and-bone-quality-of-the-femur-in-kk-ay-mice-a-type-2-diabetic-animal-model
#13
Satoshi Takagi, Takenori Yamashita, Toshihiro Miura
Although it has been recently shown that type 2 diabetics have an increased risk of hip fracture, the effects of exercise therapy to prevent this have not been clarified. We examined whether a treadmill running exercise contributes to the bone mineral density (BMD) and bone microarchitecture of the femur and what kind of exercise intensity and duration are optimum in type 2 diabetes mellitus using KK-Ay diabetic mice. The mice were divided into two running groups, one fast speed and short duration (FS), the other slow speed and long duration (SL), and a group of controls with no running (CO)...
August 4, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28761974/dicalcium-phosphate-anhydrous-an-appropriate%C3%A2-bioceramic-in-regeneration-of-critical-sized-radial-bone-defects-in-rats
#14
Ahmad Oryan, Soodeh Alidadi, Amin Bigham-Sadegh
The present study aimed to evaluate and compare the effectiveness of composites of calcium phosphates including β-tri calcium phosphate (β-TCP), dicalcium phosphate anhydrous (DCPA, monetite), mono-calcium phosphate monohydrate (MCPM), and hydroxyapatite (HA) with the chitosan-gelatin-platelet gel (CGP) on the healing of experimentally induced critical size radial bone defects in rats after 8 weeks of injury. Eighty bilateral bone defects were created in the radial bones of 40 adult male Sprague-Dawley rats...
July 31, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28761973/enhanced-identification-of-potential-pleiotropic-genetic-variants-for-bone-mineral-density-and-breast-cancer
#15
Cheng Peng, Hui-Ling Lou, Feng Liu, Jie Shen, Xu Lin, Chun-Ping Zeng, Ji-Rong Long, Kuan-Jui Su, Lan Zhang, Jonathan Greenbaum, Wei-Feng Deng, Yu-Mei Li, Hong-Wen Deng
Epidemiological and clinical evidences have shown that bone mineral density (BMD) has a close relationship with breast cancer (BC). They might potentially have a shared genetic basis. By incorporating information about these pleiotropic effects, we may be able to explore more of the traits' total heritability. We applied a recently developed conditional false discovery rate (cFDR) method to the summary statistics from two independent GWASs to identify the potential pleiotropic genetic variants for BMD and BC...
July 31, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28761972/evaluation-of-a-new-fully-automated-assay-for-plasma-intact-fgf23
#16
Jean-Claude Souberbielle, Dominique Prié, Marie-Liesse Piketty, Anya Rothenbuhler, Pierre Delanaye, Philippe Chanson, Etienne Cavalier
Several FGF23 immunoassays are available. However, they are reserved for research purposes as none have been approved for clinical use. We evaluated the performances of a new automated assay for intact FGF23 on the DiaSorin Liaison platform which is approved for clinical use. We established reference values in 908 healthy French subjects aged 18-89 years, and measured iFGF23 in patients with disorders of phosphate metabolism and in patients with chronic kidney disease (CKD). Intra-assay CV was 1.04-2.86% and inter-assay CV was 4...
July 31, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28755011/impact-of-chiropractic-manipulation-on-bone-and-skeletal-muscle-of-ovariectomized-rats
#17
A López-Herradón, R Fujikawa, M Gómez-Marín, J P Stedile-Lovatel, F Mulero, J A Ardura, P Ruiz, I Muñoz, P Esbrit, I Mahíllo-Fernández, A Ortega-de Mues
Evidence suggests that chiropractic manipulation might exert positive effects in osteoporotic patients. The aim of this study was to evaluate the effects of chiropractic manipulation on bone structure and skeletal muscle in rats with bone loss caused by ovariectomy (OVX). The 6-month old Sprague-Dawley rats at 10 weeks following OVX or sham operation (Sh) did not suffer chiropractic manipulation (NM group) or were submitted to true chiropractic manipulation using the chiropractic adjusting instrument Activator V(®) three times/week for 6 weeks as follows: Force 1 setting was applied onto the tibial tubercle of the rat right hind limb (TM group), whereas the corresponding left hind limb received a false manipulation (FM group) consisting of ActivatorV(®) firing in the air and slightly touching the tibial tubercle...
July 28, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28725909/skeletal-fluorosis-due-to-fluorocarbon-inhalation-from-an-air-dust-cleaner
#18
Katherine Peicher, Naim M Maalouf
Skeletal fluorosis (SF) is an osteosclerotic metabolic bone disorder caused by excessive ingestion or inhalation of fluoride. SF is extremely rare in developed countries. We report a case of SF due to inhalational abuse from a fluoride-containing air dust cleaner. A 33-year-old man with no past medical history presented with progressively worsening low back pain for 2 years. Physical examination was notable for loss of lumbar lordosis and tenderness over the lumbar spine. Radiographs were notable for uniform generalized osteosclerosis in the long bones, entire spine, rib cage, and pelvic bones, and loss of the normal lumbar curvature...
July 20, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28725908/cyst-like-lesions-at-chondro-osseous-junction
#19
Zijun Zhang, Jeffrey Beckett, Lew Schon
This study described and histologically characterized a cyst-like lesion (CLL) at the chondro-osseous junction. Rat knees (n = 12), with or without excessive running-induced osteoarthritis (OA), were used for counting the incidence, morphological measurements, immunohistochemistry of the CLL. A typical CLL, appearing as a void space in the matrix, was located on the tidemark at the chondro-osseous junction. The content of the CLL included types II and VI collagen, proteoglycans but not intact chondrocytes. At least one CLL was found in 5/6 osteoarthritic knees and only 2/6 in the non-osteoarthritic knees...
July 19, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28725907/development-of-a-new-immunoassay-for-human-cathepsin-k-generated-periostin-fragments-as-a-serum-biomarker-for-cortical-bone
#20
Patrick Garnero, Nicolas Bonnet, Serge L Ferrari
Periostin is a matricellular protein mainly expressed by periosteal cells and osteocytes in bone, but is also present in several other tissues. Available immunoassays use antibodies of unclear specificity. The aim of the study was to develop a bone-specific periostin ELISA based on the detection of fragments generated by the osteoclastic and osteocytic protease cathepsin K. In vitro digestion of human recombinant intact periostin by cathepsin K leads to the generation of multiple fragments. Using LS-MS/MS, it was found that the GSLQPIIK peptide was the most efficiently and abundantly generated periostin fragment...
July 19, 2017: Calcified Tissue International
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