journal
MENU ▼
Read by QxMD icon Read
search

Calcified Tissue International

journal
https://www.readbyqxmd.com/read/29754277/proton-pump-inhibitor-use-h-2-receptor-antagonist-use-and-risk-of-incident-clinical-vertebral-fracture-in-women
#1
Julie M Paik, Harold N Rosen, Catherine M Gordon, Gary C Curhan
The few prospective studies examining the relation between proton pump inhibitor (PPI) use and risk of vertebral fracture (VF) suggest a higher risk, but the magnitude of the association has been inconsistent. Moreover, no prospective studies have examined the association between substantially longer duration of PPI use and VF risk. Our objective was to determine the association between PPI use, H2 RA use, and incident clinical VF in women. We conducted a prospective study in 55,545 women participating in the Nurses' Health Study...
May 12, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29736882/a-challenging-case-of-tumor-induced-osteomalacia-pathophysiological-and-clinical-implications
#2
Luciano Colangelo, Cristiana Cipriani, Jessica Pepe, Alessandro Corsi, Chiara Sonato, Giulia Follacchio, Mirella Cilli, Walter Gianni, Federica Ferrone, Oreste Moreschini, Lorraine A Fitzpatrick, Salvatore Minisola
We investigated the usefulness of fibroblast growth factor 23 (FGF23) intraoperative assay to monitor tumor resection in patients with oncogenic osteomalacia. A 33-year-old man with 5 years' history of lumbar and pelvis pain together with multiple vertebral fractures was admitted to our hospital. He was diagnosed with ankylosing spondylitis 1 year before. Laboratory investigation showed low tubular reabsorption of phosphate (0.41 mmol/L) despite chronic hypophosphatemia (0.39/L). Increased plasma values of FGF23 (673 pg/mL; n...
May 7, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29730704/normal-bone-microstructure-and-density-but-worse-physical-function-in-older-women-treated-with-selective-serotonin-reuptake-inhibitors-a-cross-sectional-population-based-study
#3
Berit Larsson, Dan Mellström, Lisa Johansson, Anna G Nilsson, Mattias Lorentzon, Daniel Sundh
Depression in the elderly is today often treated with selective serotonin reuptake inhibitors (SSRIs) because of their favorable adverse effect profile. However, treatment with SSRIs is associated with increased risk of fractures. Whether this increased risk depends on reduced bone strength or increased fall risk due to reduced physical function is not certain. The aim was therefore to investigate if treatment with SSRIs is associated with impaired bone microstructure, bone density, or physical function in older women...
May 5, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29728722/abstracts-of-the-ects-congress-2018
#4
(no author information available yet)
No abstract text is available yet for this article.
May 4, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29725706/abaloparatide-exerts-bone-anabolic-effects-with-less-stimulation-of-bone-resorption-related-factors-a-comparison-with-teriparatide
#5
Akito Makino, Hideko Takagi, Yoshimasa Takahashi, Naoki Hase, Hiroyuki Sugiyama, Kei Yamana, Tsunefumi Kobayashi
Abaloparatide (ABL) is a novel synthetic peptide analog of parathyroid hormone-related protein. In previous reports, intermittent ABL administration showed robust bone mineral density (BMD) increase and reduced the incidence of fractures in patients with osteoporosis, while its calcemic effect was reduced, as compared with teriparatide (TPTD), a parathyroid hormone N-terminal fragment. The present study aimed to elucidate the effects of ABL on bone anabolism and bone turnover as compared with TPTD. In ovariectomized (OVX) rats, ABL increased the bone strength and BMD of lumbar spine by intermittent administration similar to TPTD...
May 3, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29721581/glycyrrhizin-suppresses-rankl-induced-osteoclastogenesis-and-oxidative-stress-through-inhibiting-nf-%C3%AE%C2%BAb-and-mapk-and-activating-ampk-nrf2
#6
Zhikun Li, Chao Chen, Xiaodong Zhu, Yifan Li, Ronghua Yu, Wei Xu
The treatment for osteoporosis involves inhibiting bone resorption and osteoclastogenesis. Glycyrrhizin (GLY) is a triterpenoid saponin glycoside known to be as the most medically efficacious component of the licorice plant. It has strong anti-inflammatory, antioxidant, and antitumor properties. We investigated the effect of GLY on osteoclastogenesis, bone resorption, and intracellular oxidative stress and its molecular mechanisms. In vitro osteoclastogenesis assays were performed using bone marrow monocytes with and without glycyrrhizin...
May 2, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29700558/differential-expression-profiles-of-circular-rnas-during-osteogenic-differentiation-of-mouse-adipose-derived-stromal-cells
#7
Ting Long, Zeyou Guo, Lu Han, Xiaoyan Yuan, Lei Liu, Wei Jing, Weidong Tian, Xiao-Hui Zheng, Wei Tang, Jie Long
Osteogenesis is a complex and tightly regulated process. Circular RNAs (circRNAs) are covalently closed RNA molecules which are thought to play a significant role in bone metabolism. The purpose of this study was to investigate the expression and putative function of circRNAs during the osteogenic differentiation of mouse adipose-derived stromal cells (mADSCs). circRNA microarrays were used to determine differential circRNAs expression at different stages during osteogenesis of mADSCs. The most frequent differentially expressed circRNAs were selected by Venn analysis and clustered among the three induced groups...
April 26, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29691609/effect-of-25-hydroxyvitamin-d-deficiency-and-its-interaction-with-prednisone-treatment-on-musculoskeletal-health-in-growing-mdx-mice
#8
Sung-Hee Yoon, Kim S Sugamori, Marc D Grynpas, Jane Mitchell
Duchenne muscular dystrophy (DMD) results from genetic mutations of the gene encoding dystrophin, leading to muscle inflammation and degeneration that is typically treated with glucocorticoids. DMD and its treatment with glucocorticoids result in poor bone health and high risk of fractures. Insufficient levels of 25-hydroxyvitamin D (25-hydroxy D) that may contribute to weakened bone are routinely found in DMD patients. To determine the effect of 25-hydroxy D deficiency, this study examined the effects of low vitamin D dietary intake with and without glucocorticoids on the musculoskeletal system of the Mdx mouse model of DMD...
April 24, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29675640/effects-of-combined-whole-body-electromyostimulation-and-protein-supplementation-on-local-and-overall-muscle-fat-distribution-in-older-men-with-sarcopenic-obesity-the-randomized-controlled-franconia-sarcopenic-obesity-franso-study
#9
Wolfgang Kemmler, Alexandra Grimm, Michael Bebenek, Matthias Kohl, Simon von Stengel
The primary aim of the project was to determine the combined effect of whole-body electromyostimulation (WB-EMS) and protein supplements on local and overall muscle/fat distribution in older man with sarcopenic obesity (SO). Community-dwelling (cdw) men ≥ 70 years with SO were randomly allocated to a WB-EMS and protein supplementation (n = 33) or a non-intervention control group (CG: n = 34). WB-EMS was conducted 1.5 sessions of 20 min/week for 16 weeks. Whey protein supplementation aimed to ensure a daily intake of 1...
April 19, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29654343/osteoimmunology
#10
EDITORIAL
Stuart H Ralston, Georg Schett
No abstract text is available yet for this article.
April 13, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29594493/reliability-of-hr-pqct-derived-cortical-bone-structural-parameters-when-using-uncorrected-instead-of-corrected-automatically-generated-endocortical-contours-in-a-cross-sectional-study-the-maastricht-study
#11
Ellis A C de Waard, Cindy Sarodnik, Alexander Pennings, Joost J A de Jong, Hans H C M Savelberg, Tineke A van Geel, Carla J van der Kallen, Coen D A Stehouwer, Miranda T Schram, Nicolaas Schaper, Pieter C Dagnelie, Piet P M M Geusens, Annemarie Koster, Bert van Rietbergen, Joop P W van den Bergh
Most HR-pQCT studies examining cortical bone use an automatically generated endocortical contour (AUTO), which is manually corrected if it visually deviates from the apparent endocortical margin (semi-automatic method, S-AUTO). This technique may be prone to operator-related variability and is time consuming. We examined whether the AUTO instead of the S-AUTO method can be used for cortical bone analysis. Fifty scans of the distal radius and tibia from participants of The Maastricht Study were evaluated with AUTO, and subsequently with S-AUTO by three independent operators...
March 29, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29589061/overview-of-osteoimmunology
#12
REVIEW
Asuka Terashima, Hiroshi Takayanagi
Aberrant or prolonged immune responses often affect bone metabolism. The investigation on bone destruction observed in autoimmune arthritis contributed to the development of research area on effect of the immune system on bone. A number of reports on bone phenotypes of immunocompromised mice indicate that the immune and skeletal systems share various molecules, including transcription factors, signaling molecules, and membrane receptors, suggesting the interplay between the two systems. Furthermore, much attention has been paid to the modulation of immune cells, including hematopoietic progenitor cells, by bone cells in the bone marrow...
March 27, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29589060/associations-between-objectively-measured-physical-activity-body-composition-and-sarcopenia-findings-from-the-hertfordshire-sarcopenia-study-hss
#13
Leo D Westbury, Richard M Dodds, Holly E Syddall, Alicja M Baczynska, Sarah C Shaw, Elaine M Dennison, Helen C Roberts, Avan Aihie Sayer, Cyrus Cooper, Harnish P Patel
Regular physical activity (PA) is associated with reduced risk of the development and progression of musculoskeletal, metabolic and vascular disease. However, PA declines with age and this can contribute to multiple adverse outcomes. The aims of this study were to describe the relationship between accelerometer-determined PA, body composition and sarcopenia (the loss of muscle mass and function with age). Seven-day PA was measured using the GENEactiv accelerometer among 32 men and 99 women aged 74-84 years who participated in the Hertfordshire Sarcopenia Study...
March 27, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29582133/marrow-adipose-tissue-in-older-men-association-with-visceral-and-subcutaneous-fat-bone-volume-metabolism-and-inflammation
#14
Ebrahim Bani Hassan, Oddom Demontiero, Sara Vogrin, Alvin Ng, Gustavo Duque
Marrow (MAT) and subcutaneous (SAT) adipose tissues display different metabolic profiles and varying associations with aging, bone density, and fracture risk. Using a non-invasive imaging methodology, we aimed to investigate the associations between MAT, SAT, and visceral fat (VAT) with bone volume, bone remodeling markers, insulin resistance, and circulating inflammatory mediators in a population of older men. In this cross-sectional study, 96 healthy men (mean age 67 ± 5.5) were assessed for anthropometric parameters, body composition, serum biochemistry, and inflammatory panel...
March 26, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29582132/association-of-plasma-irisin-with-bone-mineral-density-in-a-large-chinese-population-using-an-extreme-sampling-design
#15
Long-Fei Wu, Dong-Cheng Zhu, Chang-Hua Tang, Bing Ge, Ju Shi, Bing-Hua Wang, Yi-Hua Lu, Pei He, Wen-Yu Wang, Si-Qi Lu, Jiao Zhong, Xu Zhou, Kan Zhu, Wen Ji, Hong-Qin Gao, Hong-Bo Gu, Xing-Bo Mo, Xin Lu, Lei Zhang, Yong-Hong Zhang, Fei-Yan Deng, Shu-Feng Lei
Irisin, a myokine produced by skeletal muscle in response to physical exercise, promotes trans-differentiation of white adipose tissue into brown adipose tissue. Recent evidences suggested that irisin also plays an important role in the control of bone metabolism. This study aimed to ascertain the relationship between plasma irisin and bone mineral density (BMD) in Chinese population by adoption of an extreme sampling method. Based on a large and screened Chinese elderly population (N = 6308), two subgroups with extremely high and low hip BMD were selected for discovery (N = 80, high vs...
March 26, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29572562/autosomal-recessive-osteogenesis-imperfecta-caused-by-a-novel-homozygous-col1a2-mutation
#16
Alice Costantini, Symeon Tournis, Anders Kämpe, Noor Ul Ain, Fulya Taylan, Artemis Doulgeraki, Outi Mäkitie
Osteogenesis imperfecta (OI) is a skeletal dysplasia characterized by brittle bones and extraskeletal manifestations. The disease phenotype varies greatly. Most commonly, OI arises from monoallelic mutations in one of the two genes encoding type I collagen, COL1A1 and COL1A2 and is inherited as an autosomal dominant trait. Here, we describe a consanguineous family with autosomal recessive OI caused by a novel homozygous glycine substitution in COL1A2, NM_000089.3: c.604G>A, p.(Gly202Ser), detected by whole-genome sequencing...
March 23, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29523928/microrna-218-promotes-osteogenic-differentiation-of-mesenchymal-stem-cells-and-accelerates-bone-fracture-healing
#17
Liu Shi, Lu Feng, Yang Liu, Ji-Qiang Duan, Wei-Ping Lin, Jin-Fang Zhang, Gang Li
As a regulator of osteogenesis, microRNA-218 (miR-218) is reported to promote osteogenesis of mesenchymal stem cells (MSCs). However, the in vivo osteogenic effect of miR-218 remains elusive. In this study, miR-218 was confirmed to promote osteogenic differentiation of MSCs by stimulating the alkaline phosphatase activity, calcium nodule formation, and osteogenic marker gene expression. For in vivo study, the miR-218-overexpressing BMSCs were locally administrated into the fracture sites in a femur fracture mouse model...
March 9, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29516129/prevalence-of-chronic-hypoparathyroidism-in-a-mediterranean-region-as-estimated-by-the-analysis-of-anonymous-healthcare-database
#18
Luisella Cianferotti, Simone Parri, Giorgio Gronchi, Gemma Marcucci, Cristiana Cipriani, Jessica Pepe, Marco Raglianti, Salvatore Minisola, Maria Luisa Brandi
Epidemiological data on prevalence and incidence of chronic hypoparathyroidism are still scarce. This study aimed to establish prevalence of chronic hypoparathyroidism and incidence of surgical hypoparathyroidism using the analysis of electronic anonymous public health care database. Data referred to a 5-year period (2009-2013, Region of Tuscany, Italy, as a sample representative of the whole Mediterranean/European population, estimated mean population: 3,750,000 inhabitants) were retrieved by the analysis of pharmaceutical distribution dataset, containing data related to drugs reimbursed by public health system, hospital discharge and procedures codes, and ICD9 exemption codes for chronic diseases...
March 8, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29511787/hypoparanet-a-database-of-chronic-hypoparathyroidism-based-on-expert-medical-surgical-centers-in-italy
#19
Gemma Marcucci, Luisella Cianferotti, Simone Parri, Paola Altieri, Emanuela Arvat, Salvatore Benvenga, Corrado Betterle, Marta Bondanelli, Marco Boscaro, Valentina Camozzi, Grazia Maria Centaro, Filomena Cetani, Iacopo Chiodini, Anna Ciampolillo, Annamaria Colao, Sabrina Corbetta, Maria Laura De Feo, Ettore Degli Uberti, Antongiulio Faggiano, Rachele Fornari, Achille Lucio Gaspari, Francesco Giorgino, Valeria Giuliani, Maurizio Iacobone, Nadia Innaro, Olga Lamacchia, Andrea Lenzi, Giovanna Mantovani, Claudio Marcocci, Laura Masi, Silvia Migliaccio, Serena Palmieri, Renato Pasquali, Giuliano Perigli, Valentina Piccini, Elisabetta Romagnoli, Rosaria Maddalena Ruggeri, Francesco Rulli, Maria Teresa Samà, Giuseppe Tomaino, Francesco Trimarchi, Maria Chiara Zatelli, Maria Luisa Brandi
Hypoparathyroidism is a rare disease characterized by low serum calcium levels and absent or deficient parathyroid hormone level. Regarding the epidemiology of chronic hypoparathyroidism, there are limited data in Italy and worldwide. Therefore, the purpose of this study was to build a unique database of patients with chronic hypoparathyroidism, derived from the databases of 16 referral centers for endocrinological diseases, affiliated with the Italian Society of Endocrinology, and four centers for endocrine surgery with expertise in hypoparathyroidism, to conduct an epidemiological analysis of chronic hypoparathyroidism in Italy...
March 6, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29500623/irradiation-induced-compositional-effects-on-human-bone-after-extracorporeal-therapy-for-bone-sarcoma
#20
S Chauhan, S A Khan, A Prasad
The present study investigates Raman scattering of human bone irradiated with 50 Gy single dose during therapeutic treatment of Ewing and Osteosarcoma. Bone quality was evaluated via mineral-to-matrix ratio, degree of crystallinity, change in amount of calcium, and carbonate substitution. Alteration in collagen and its cross-links was quantified through second-derivative deconvolution of Amide I peak. A dose of 50 Gy radiation leads to almost 50% loss of mineral content, while maintaining mineral crystallinity, and small changes in carbonate substitution...
March 2, 2018: Calcified Tissue International
journal
journal
27647
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"