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Neurological Research

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https://www.readbyqxmd.com/read/29790425/hypoxic-preconditioning-reduces-propofol-induced-neuroapoptosis-via-regulation-of-bcl-2-and-bax-and-downregulation-of-activated-caspase-3-in-the-hippocampus-of-neonatal-rats
#1
Jing Lv, Yubing Liang, Youbing Tu, Jing Chen, Yubo Xie
OBJECTIVE:  Evidence has shown that propofol may cause widespread apoptotic neurodegeneration. Hypoxic preconditioning (HPC) was previously demonstrated to provide neuroprotection and brain recovery from either acute or chronic neurodegeneration in several cellular and animal models. Therefore, the present study was designed to investigate the protective effects of hypoxic preconditioning on apoptosis caused by propofol in neonatal rats. METHODS: Propofol (100 mg/kg) was given to 7-day-old (P7) Sprague Dawley pups...
May 23, 2018: Neurological Research
https://www.readbyqxmd.com/read/29785882/the-relationship-between-repetitive-finger-movement-and-quality-of-life-in-parkinson-s-disease
#2
Elizabeth L Stegemöller, Jennifer Uzochukwu, Mack Shelley
BACKGROUND: Repetitive finger movement significantly impacts daily living activities, but there have been limited studies determining how repetitive finger movement impacts quality of life (QOL) in persons with Parkinson's disease (PD). The purpose of this study was to determine the relationship between impairment in repetitive finger movement and QOL in persons with PD. METHODS: Eighty-four participants with PD completed a repetitive movement task and the Parkinson's Disease Questionnaire (PDQ)...
May 22, 2018: Neurological Research
https://www.readbyqxmd.com/read/29781786/sitagliptin-rescues-memory-deficits-in-parkinsonian-rats-via-upregulating-bdnf-to-prevent-neuron-and-dendritic-spine-loss
#3
Jing Li, Shuhu Zhang, Chenye Li, Mei Li, Lan Ma
OBJECTIVES: Parkinson's disease (PD) is a neurodegenerative disease with high morbidity among adults worldwide that causes tremendous trouble to people's lives. The purpose of this study was to investigate the impact of sitagliptin on PD and its potential mechanism. METHODS: First, the memory of rats in each group was evaluated with the Morris water maze (MWM) test and the passive avoidance test. Then, both brain-derived neurotrophic factor (BDNF) protein and mRNA levels were detected by ELISA and qPCR assays, respectively...
May 21, 2018: Neurological Research
https://www.readbyqxmd.com/read/29781781/gene-expression-microarray-analysis-reveals-prognostic-markers-of-survival-in-high-grade-astrocytomas
#4
Jun Yang, Ziming Hou, Changjiang Wang, Hao Wang, Hongbing Zhang
OBJECTIVE: High grade astrocytoma (HGA) as an aggressive brain tumor, is always correlated with poor prognosis. In this paper, we aimed to explore the genetic prognostic biomarkers for HGA. METHODS: The genome-wide expression profile of 26 brain tumor samples obtained from 26 patients with HGA was downloaded from Gene Expression Omnibus. The risk genes for prognosis of HGA were identified and verified by the data in TCGA database. Protein-protein interaction (PPI) network of risk factor genes was constructed and significant module was screened...
May 21, 2018: Neurological Research
https://www.readbyqxmd.com/read/29726751/evaluation-of-the-antiparkinsonism-and-neuroprotective-effects-of-hydrogen-sulfide-in-acute-6-hydroxydopamine-induced-animal-model-of-parkinson-s-disease-behavioral-histological-and-biochemical-studies
#5
Mohammad Sarukhani, Hashem Haghdoost-Yazdi, Ali Sarbazi Golezari, Arvin Babayan-Tazehkand, Tahere Dargahi, Nafiseh Rastgoo
INTRODUCTION: Studies have shown that hydrogen sulfide (H2 S), a gaseous neurotransmitter, has neuroprotective effect. Here, we evaluated the neuroprotective activity of H2 S in acute 6-hydroxydopamine (6-OHDA) animal model of Parkinson's disease (PD). METHODS: 6-OHDA was injected through stereotaxic surgery into medial forebrain bundle (MFB) of the right hemisphere to induce severe and fast degeneration in dopaminergic neurons of substantia nigra (SN). NaHS, as donor of H2 S, was daily injected at doses of 3 and 5...
May 4, 2018: Neurological Research
https://www.readbyqxmd.com/read/29726748/efficacy-of-neuromuscular-electrical-stimulation-in-improving-the-negative-psychological-state-in-patients-with-cerebral-infarction-and-dysphagia
#6
Yanfang Zeng, James Yip, Hongli Cui, Longfei Guan, Haomeng Zhu, Weidong Zhang, Huishan Du, Xiaokun Geng
Objective To observe the improvement of negative affect disorders in patients with cerebral infarction and dysphagia by neuromuscular electrical stimulation. Methods One hundred and twelve patients with cerebral infarction and dysphagia were selected and randomized into treatment (n = 59) and control (n = 53) groups. Similar swallowing function was found in both groups before treatment: (1) Water-drinking test in the treatment group proved swallowing function Level III in 24 cases, Level IV in 22 cases and Level V in 13 cases; (2) in the control group, swallowing function was Level III in 21 cases, Level IV in 20 cases and Level V in 12 cases...
May 4, 2018: Neurological Research
https://www.readbyqxmd.com/read/29718773/high-thiamine-diphosphate-level-as-a-protective-factor-for-alzheimer-s-disease
#7
Changpeng Wang, Guoqiang Fei, Xiaoli Pan, Shaoming Sang, Lijun Wang, Chunjiu Zhong, Lirong Jin
Objectives Thiamine diphosphate (TDP) is an indispensable coenzyme for three key enzymes in glucose metabolism. Reduced TDP levels in patients with Alzheimer's disease (AD) has been widely demonstrated and is a diagnostic biomarker for the disease. In this study, we further explored the correlation between altered TDP metabolism and AD along with other risk factors. Methods A 1:1 case-control study was employed with 90 AD patients and 90 control subjects with normal-range cognitive abilities as assayed by the Mini Mental Status Evaluation...
May 2, 2018: Neurological Research
https://www.readbyqxmd.com/read/29688151/bexarotene-attenuates-early-brain-injury-via-inhibiting-micoglia-activation-through-ppar%C3%AE-after-experimental-subarachnoid-hemorrhage
#8
Li Tu, Xiu-Lin Yang, Qian Zhang, Qian Wang, Tian Tian, Dan Liu, Xiang Qu, Jin-Yong Tian
Objectives Early brain injury (EBI) is considered to be one of the main causes of poor outcome in subarachnoid hemorrhage (SAH) patients. Bexarotene is an agonist of retinoid X receptor and plays a protective role in central nervous system diseases. However, the exact role of bexarotene in SAH has not been reported. Therefore, the present study was to determine whether bexarotene administration attenuate EBI after SAH in mice and to explore the underlying mechanism. Methods SAH was induced in C57BL/6 mice by endovascular perforation...
April 24, 2018: Neurological Research
https://www.readbyqxmd.com/read/29688134/genistein-attenuates-brain-damage-induced-by-transient-cerebral-ischemia-through-up-regulation-of-nrf2-expression-in-ovariectomized-rats
#9
Zhong-Yan Miao, Xu Xia, Lu Che, Yan-Tao Song
OBJECTIVE: Postmenopausal women possess higher incidence of stroke and worse prognosis. Although estrogen replacement therapy has obvious neuroprotective effects against stroke, it is always accompanied with several adverse effects and undesired outcomes. Genistein, a natural phytoestrogen, has been indicated to be a potential neuroprotective alternative for postmenopausal women against stroke. However, the role and mechanism of genistein's neuroprotective effects against stroke in ovariectomized rats have rarely been explored...
April 24, 2018: Neurological Research
https://www.readbyqxmd.com/read/29683786/real-world-treatment-of-large-vessel-occlusions-combined-outcomes-of-directly-presenting-and-transferred-in-patients-to-a-stroke-center
#10
Ganesh Asaithambi, Amy L Castle, Lana J Stein, Emily H Marino, Bridget M Ho, Andrew C Wallace-Jackson, Sandra K Hanson, Jeffrey P Lassig
Background Stroke patients transferred in for endovascular treatment (ET) may have lower chances for favorable outcomes compared to those who presented directly to a ET-capable hospital. We describe our real-world experience of ET in AIS, especially among patients transferred in. Materials and methods AIS patients receiving ET from January 2015 to November 2016 were reviewed. We calculated median onset to groin puncture (OTP) and groin puncture to recanalization times (PTR), location of target vessel treated, rate of concurrent intravenous (IV) alteplase use, and rate of successful recanalization as defined by TICI ≥ 2b...
April 23, 2018: Neurological Research
https://www.readbyqxmd.com/read/29683785/association-study-of-cacna1c-polymorphisms-with-large-artery-atherosclerotic-stroke-in-chinese-han-population
#11
Chen Peng, Ying Ding, Xin Yi, Zhiqiang Dong, Limei Cao, Qiang Li, Haiyan Ren, Lin He, Daizhan Zhou, Xu Chen
Aims Ischemic stroke (IS) is one of the most common diseases of neurology and the main cause of death and disability in Chinese population. CACNA1C was considered to be involved in the process of atherosclerosis, but there was little information about the association between genotypic polymorphisms of CACNA1C and ischemic stroke. Our study was designed to elucidate the relationship between four single-nucleotide polymorphisms (SNPs) variants in CACNA1C gene and the risk of large-artery atherosclerotic (LAA) stroke patients...
April 23, 2018: Neurological Research
https://www.readbyqxmd.com/read/29683412/225-intracranial-aneurysms-treated-with-the-low-profile-visualized-intraluminal-support-lvis-stent-a-single-center-retrospective-study
#12
Wei Su, Yisen Zhang, Junfan Chen, Jian Liu, Gary Rajah, Xinjian Yang
Background For the treatment of intracranial aneurysms, the low-profile visualized intraluminal support (LVIS) stent is a new generation of highly visible-braided stent that was recently introduced in China. Here, we report our single-center retrospective experience of safety and efficacy utilizing LVIS for stent-assisted coiling of intracranial aneurysms. Methods We included 218 patients with intracranial aneurysms consecutively treated with LVIS SR stents at our center in this study. Postoperative and follow-up embolization scores, procedural complications, clinical and angiographic findings at mid-term follow-up, as well as recurrence rate, preoperative and follow-up mRS scores were analyzed...
April 23, 2018: Neurological Research
https://www.readbyqxmd.com/read/29683403/paracellular-tightness-and-the-functional-expression-of-efflux-transporters-p-gp-and-bcrp-in-bend3-cells
#13
Shu Yang, Hong Jin, Zhigang Zhao
Objective The blood-brain barrier (BBB), regulating brain homeostasis and limiting the entry of most drugs, is characterized by intercellular tight junctions and the presence of transporters. In this study, the paracellular tightness and functional expression of efflux transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) were evaluated in mouse brain immortalized cell line bEnd3 to prove it as a useful BBB-mimicking system for biological and pharmacological research. Methods The presence of P-gp, BCRP and tight junction proteins occludin, claudin-5 and ZO-1 were validated by RT-PCR and Western blot...
April 23, 2018: Neurological Research
https://www.readbyqxmd.com/read/29681219/antidepressant-like-effects-of-embelin-and-its-possible-mechanisms-of-action-in-chronic-unpredictable-stress-induced-mice
#14
Bailing Wang, Xiaoqin Chen, Tiantian Zhou, Xiaoying Wang
Objectives Embelin, a principal active constituent of embelin ribes burm, has good therapeutic effects on various diseases. To explore the effects and underlying mechanisms of embelin on depression, we made a preliminary study to clarify this issue. Methods We first used chronic unpredictable stress (CUS) to construct the model of depression in mice. Then, we determined the effects of embelin on CUS-induced behavioral dysfunction using open field test, sucrose preference test, tail suspension test and forced swimming test...
April 21, 2018: Neurological Research
https://www.readbyqxmd.com/read/29681214/pathogenesis-of-epileptic-seizures-and-epilepsy-after-stroke
#15
Huajun Yang, Gary Rajah, Anchen Guo, Yongjun Wang, Qun Wang
Stroke is an important cause of seizures and epilepsy in adults, particularly among the elderly. The incidence of stroke increases yearly as life expectancy increases and the number of patients with post-stroke seizures and epilepsy is also rising. Post-stroke epilepsy accounts for nearly 50% of newly diagnosed epilepsy among patients over 60 years of age. With increasing stroke awareness and advanced treatments, increased attention is paid to post-stroke seizures and epilepsy including its diagnosis and treatment...
April 21, 2018: Neurological Research
https://www.readbyqxmd.com/read/29663852/decreased-sleep-quality-in-parkinson-s-patients-is-associated-with-higher-anxiety-and-depression-prevalence-and-severity-and-correlates-with-pain-intensity-and-quality
#16
Abdul Qayyum Rana, Abdul Rehman M Qureshi, Yazan Shamli Oghli, Yosuf Saqib, Bilal Mohammed, Zainab Sarfraz, Ruqqiyah Rana
OBJECTIVE: Pain, poor sleep quality, restless legs syndrome (RLS), and other symptoms are frequently reported by patients with Parkinson's disease (PD). However, the impact that pain severity and interference has on non-motor symptoms (NMS) has not been extensively studied. The objective of the present study is to explore the relationship between sleep quality in PD to pain and other NMS that affect quality of life. METHODS: The study included 100 PD patients and 100 age and gender-matched controls assessed for pain severity and pain interference using the Brief Pain Inventory and sleep quality using the Pittsburgh Sleep Quality Index...
April 17, 2018: Neurological Research
https://www.readbyqxmd.com/read/29663848/evaluation-of-the-association-between-sexual-dysfunction-and-demyelinating-plaque-location-and-number-in-female-multiple-sclerosis-patients
#17
Volkan Solmaz, Hatice Kose Ozlece, Aydın Him, Ayfer Güneş, Christian Cordano, Durdane Aksoy, Yahya Çelik
Purpose To investigate the frequency of sexual dysfunction (SD) in female multiple sclerosis (MS) patients and to explore its association with the location and number of demyelinating lesions. Material and Methods We evaluated 42 female patients and 41 healthy subjects. All patients underwent neurological examination and 1.5 T brain and full spinal MRI. All subjects completed the female sexual function index (FSFI), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Short-Form 36 Quality of Life Scale (SF-36)...
April 17, 2018: Neurological Research
https://www.readbyqxmd.com/read/29623817/restless-legs-syndrome-in-patients-infected-with-helicobacter-pylori
#18
Farzaneh Rezvani, Mohammad Sayadnasiri, Omid Rezaei
Objective Although the etiology of restless legs syndrome (RLS) is yet to be discovered, some studies have mentioned the effect of infectious diseases in occurrence of RLS. This study aims to determine the association between common Helicobacter pylori (H. pylori) infection and occurrence of RLS. Methods In this descriptive analytical cross-sectional study, patients with RLS who were referred to the Internal Medicine Clinic of Fayazbakhsh Hospital in Tehran from September to December 2016 were evaluated. Patients with underlying diseases that would lead to secondary RLS were excluded from the study...
April 6, 2018: Neurological Research
https://www.readbyqxmd.com/read/29623781/sildenafil-protective-effects-on-high-glucose-induced-neurotoxicity-in-pc12-cells-the-role-of-oxidative-stress-apoptosis-and-inflammation-pathways-in-an-in-vitro-cellular-model-for-diabetic-neuropathy
#19
Saeedeh Saberi Firouzi, Nazanin Namazi Sarvestani, Azam Bakhtiarian, Mahmoud Ghazi Khansari, Mohammad Yahya Karimi, Akram Ranjbar, Majid Safa, Asieh Hosseini
Objectives Diabetic neuropathy (DN) induces lifetime disability and there is currently no effective therapy to treat or to minimize patients suffering, so it is thereby imperative to develop therapeutic strategies for this disease. Since oxidative stress, mitochondrial dysfunction, apoptosis, and inflammation are crucial mechanisms in development and progression of DN, it is important to explore tools by which one can reduce factors related to these pathways. Herein, the understandings of the sildenafil neuroprotective effect through increase of cGMP level and the mediation of oxidative stress, apoptosis, and inflammation pathways on neurotoxicity induced by high glucose (HG) in PC12 cells as an in vitro cellular model for DN were investigated...
April 6, 2018: Neurological Research
https://www.readbyqxmd.com/read/29623778/involvement-of-dopamine-system-in-the-regulation-of-the-brain-corticotropin-releasing-hormone-in-paraventricular-nucleus-in-a-rat-model-of-chronic-visceral-pain
#20
Ning-Ning Ji, Jie Kang, Rong Hua, Yong-Mei Zhang
Objective We aimed to investigate the mechanism of paraventricular nucleus (PVN) and ventral tegmental area (VTA) circuit in the pathogenesis of visceral pain-depression with a rat model induced by neonatal and adult colorectal distension (CRD). Methods Neonate male Sprague-Dayley (SD) rats underwent CRD on postnatal days 8, 10, and 12, and when matured, were tested for adult abdominal withdrawal reflex (AWR) scores to assess visceral hypersensitivity. The forced swimming test was employed to evaluate depression-like behaviors...
April 6, 2018: Neurological Research
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