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Neurological Research

Cenk Eraslan, Ahmet Acarer, Serkan Guneyli, Esra Akyuz, Elcin Aydin, Zafer Colakoglu, Omer Kitis, Mehmet Cem Calli
OBJECTIVES: To evaluate the magnetic resonance imaging (MRI)-derived parameters in differentiation of patients with progressive supranuclear palsy (PSP) from patients with Parkinson's disease (PD), multiple system atrophy (MSA), and control subjects was aimed. METHODS: Thirty-three patients [mean age, 65.21 ± 4.75 years; PSP (n = 9), MSA (n = 8), PD (n = 6), and control subjects (n = 10)] who have undergone cranial MRI were included in this retrospective study...
October 30, 2018: Neurological Research
Fei-Fei Liu, Shuang Zhao, Peng Liu, Shu-Ping Huo
OBJECTIVE: To explore the influences of mammalian target of rapamycin (mTOR) signaling pathway on ketamine-induced apoptosis, oxidative stress and Ca2+ concentration in the hippocampal neurons of rats. METHODS: The primary hippocampal neurons isolated from fetal Sprague Dawley rats were treated with ketamine (0, 50, 100 and 500 μM) for 4 days to observe its effect on mTOR signaling pathway and apoptosis of rat hippocampal neurons. Then, the hippocampal neurons were divided into C (Control), R (Rapamycin, an inhibitor of mTOR signaling pathway), K (Ketamine) and R + K (Rapamycin + Ketamine) groups to detect the apoptosis, reactive oxygen species (ROS) production, and Ca2+ concentration via the terminal transferase uridyl nick end labelling (TUNEL) assay, dichloro-dihydro-fluorescein diacetate (DCFH-DA) method and Fluo-3 acetoxymethyl ester (Fluo-3AM) staining, respectively...
October 29, 2018: Neurological Research
Muhammad Khizar Abbas, Muhammad Liaquat Raza, Syed Sajjad Haider Zaidi, Bilal Muhammad Khan, Uwe Heinemann
Epilepsy is a neurological disorder affecting 50 million individuals globally. Modern research has inspected the likelihood of forecasting epileptic seizures. Algorithmic investigations are giving promising results for seizure prediction. Though mostly seizure prediction algorithm uses pre-ictal (prodromal symptoms) events for prediction. On the contrary, prodromal symptoms may not necessarily be present in every patient or subject. This paper focuses on seizure forecasting regardless of the presence of pre-ictal (prodromal symptoms) using the single robust feature with maximum accuracy...
October 17, 2018: Neurological Research
Xiaoli Zhang, Nan Jiang, Jing Li, Dongyan Zhang, Xiaohong Lv
BACKGROUND/AIMS: Paclitaxel is largely used as a chemotherapeutic agent for the treatment of several types of cancers. However, one of the significant limiting complications of paclitaxel is painful peripheral neuropathy during its therapy. The purposes of this study were to examine (1) the effects of blocking mammalian target of rapamycin (mTOR) on mechanical and thermal hypersensitivity evoked by paclitaxel; and (2) the underlying mechanisms responsible for the role of mTOR in regulating paclitaxel-induced neuropathic pain...
October 16, 2018: Neurological Research
Junya Aoki, Kazumi Kimura, Naomi Morita, Masafumi Harada, Shinji Nagahiro
METHODS: This was a retrospective cohort study. Data from 165 patients, with middle cerebral occlusion before t-PA therapy (from the YAMATO study databank), were retrospectively evaluated. Patients were classified into diabetic (D) or non-diabetic (ND) groups based on the history of diabetes mellitus (DM) or hemoglobin A1c levels of ≥ 6.5%. Arterial recanalization was assessed using magnetic resonance angiography or digital subtraction angiography at 2 points: 1) early recanalization, within 2 h; 2) delayed complete recanalization at 24 h...
October 15, 2018: Neurological Research
Min-Keun Song, Eun-Jong Kim, Jung-Kook Kim, Hyeng-Kyu Park, Sam-Gyu Lee
OBJECTIVE: This study investigated the effect of regular swimming exercise according to the duration-intensity on neurocognitive function in a cerebral infarction rat model. METHODS: Forty male Sprague-Dawley 10-week-old rats, weighing 300 ± 50 g, were subjected to photothrombotic cerebral infarction. The remaining 36 rats were randomly divided into four groups (n = 9 per group: non-exercise (group A); swimming exercise of short duration-intensity (5 min/day, group B); swimming exercise of moderate duration-intensity (10 min/day, group C); and swimming exercise of long duration-intensity (20 min/day, group D)...
October 12, 2018: Neurological Research
Lingling Fan, Shan Ma, Yongxiang Yang, Zhongjun Yan, Junchao Li, Zhuyi Li
OBJECTIVE: The clinical differences of early-onset myasthenia gravis (EOMG) and late-onset MG (LOMG) have not been elucidated in China. In order to clarify this, a retrospective study was conducted in 985 MG patients, whose disease duration was longer than 3 years. METHODS: These patients were separated into EOMG and LOMG according to the onset age of 50 years. The clinical differences including demographics, clinical features, thymus abnormalities and comorbidities of EOMG and LOMG patients were analyzed...
October 12, 2018: Neurological Research
Jonathan Rychen, Davide Croci, Michel Roethlisberger, Erez Nossek, Matthew B Potts, Ivan Radovanovic, Howard A Riina, Luigi Mariani, Raphael Guzman, Daniel W Zumofen
OBJECTIVE: To clarify the reported experience with keyhole approaches for the treatment of intracranial aneurysms. METHODS: The PubMed and Embase databases were searched up to December 2017 for full-text publications that report the treatment of aneurysms with the eyebrow variant of the supraorbital craniotomy (SOC), the minipterional craniotomy, or the eyelid variant of the SOC. The anatomical distribution of aneurysms, the postoperative aneurysm occlusion rate, and the type and rate of complications were examined using univariate analysis...
October 12, 2018: Neurological Research
Maria Angela Samis Zella, Caroline May, Thomas Müller, Maike Ahrens, Lars Tönges, Ralf Gold, Katrin Marcus, Dirk Woitalla
BACKGROUND/AIMS: Pain is a non-motor symptom of Parkinson's disease (PD). Few systematic studies have been carried out and there are still no guidelines on pain therapy in PD. Additionally, within the studies that do exist, gender-specific differences in pain perception are often the focus, though no consistent results have to date been obtained. The first main aim of our study was therefore to map pain in the largest PD study group to date, with the second being the analysis of the impact of different pain therapies in PD...
October 12, 2018: Neurological Research
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No abstract text is available yet for this article.
October 12, 2018: Neurological Research
Yang Wang, Shiyu Hu, Lijie Ren, Zhihao Lei, Tao Lan, Jingjing Cai, Chao Li
INTRODUCTION: Lipoprotein-associated phospholipase A2 (Lp-PLA2 ) is a well-known risk factor of atherosclerotic vascular diseases. Nevertheless, its role in the acute phase of ischemic stroke is still unclear. The aim of this study is to identify the relationship between Lp-PLA2 levels and early neurological deterioration (END) in acute ischemic stroke patients with Trial of Org 10 172 in Acute Stroke Treatment (TOAST) subtype of large arterial atherosclerosis (LAA). METHODS: We enrolled Chinese patients with first ever acute ischemic stroke admitted to Neurology Department of Shenzhen Second People's Hospital within 48 h from onset of symptoms during January - November 2015...
October 8, 2018: Neurological Research
Cuiying Liu, Jian Yang, Chencheng Zhang, Xiaokun Geng, Heng Zhao
OBJECTIVE: Remote limb ischemic postconditioning (RIPostC) protects the brain from damage induced by transient focal ischemia/reperfusion. However, the underlying mechanism remains unclear. METHODS: RIPostC induced by 10 min of occlusion and another 10 min releasing of blood flow for three cycles in the hind limbs was performed immediately after the reperfusion in a focal ischemia mice model. Neurological scores, immune cell population in the blood, spleen and lymph node, and inflammatory factors in the blood and brain were analyzed 2 days after the reperfusion...
October 3, 2018: Neurological Research
Wei Dong, Xuanying Chen, Menghong Wang, Zeqi Zheng, Xing Zhang, Qunlin Xiao, Xiaoping Peng
OBJECTIVES: In this study, we aim to determine how CUG-expansion and the abundance of Celf1 regulates normal myocyte differentiation and reveal the role ofmiR-206 in myotonic dystrohy and explore a possible gene therapy vector. METHODS:  we set up CUG-expansion and Celf1 overexpression C2C12 cell models to imitate the myocyte differentiation defects of DM1, then transfected AdvmiR-206 into cell models, tested the level of myogenic markers MyoD, MyoG, Mef2c, Celf1 by RT-PCRand Western Blotting, detected myotube formation by myosin heavy chain immunostaining...
October 3, 2018: Neurological Research
Kenichi Yamada, Yuji Suzuki, Makiko Okuyama, Masaki Watanabe, Tsutomu Nakada
OBJECTIVE: This study aimed to investigate brain developmental alterations in individuals exposed to childhood maltreatment (CM) with dissociative experiences and motor coordination symptoms using diffusion tensor imaging on a 3Tesla (3T) magnetic resonance (MR) system. METHODS: Five individuals exposed to CM who manifest behavioral and developmental problems with dissociative experiences and motor coordination symptoms (age range: 14-18 years; all female), as well as seven age- and gender-matched normal control individuals, participated in the study using a 3T MR system...
September 13, 2018: Neurological Research
John K Yue, Ethan A Winkler, Ross C Puffer, Hansen Deng, Ryan R L Phelps, Sagar Wagle, Molly Rose Morrissey, Ernesto J Rivera, Sarah J Runyon, Mary J Vassar, Sabrina R Taylor, Maryse C Cnossen, Hester F Lingsma, Esther L Yuh, Pratik Mukherjee, David M Schnyer, Ava M Puccio, Alex B Valadka, David O Okonkwo, Geoffrey T Manley, The Track-Tbi Investigators
INTRODUCTION: Mild traumatic brain injury (MTBI) can cause persistent functional deficits and healthcare burden. Understanding the association between intracranial contusions and outcome may aid in MTBI treatment and prognosis. METHODS: MTBI patients with Glasgow Coma Scale 13-15 and 6-month outcomes [Glasgow Outcome Scale-Extended (GOSE)], without polytrauma from the prospective TRACK-TBI Pilot study were analyzed. Intracranial contusions on computed tomography (CT) were coded by location...
September 3, 2018: Neurological Research
Jagriti Saini, Maitreyee Dutta
OBJECTIVES: An Electroencephalogram (EEG) is the result of co-operative actions performed by brain cells. In other words, it can be defined as the time course of extracellular field potentials that are generated due to the synchronous action of cells. It is widely used for the analysis and diagnosis of several conditions. But this clinical data use to be multi-dimensional, context-dependent, complex, and it causes a concoction of various computing related research challenges. The objective of this study was to develop a computer-aided diagnosis system for epilepsy detection using EEG signals to ease the diagnosis process...
August 29, 2018: Neurological Research
Zong-Li Xia, Qing-Mei Qin, Qing-Ying Zhao
OBJECTIVES: Multiple sclerosis (MS) is a T-cell-mediated disease of the central nervous system that develops in individuals possessing a complex susceptibility trait. We explored relationship between gene polymorphisms in MS. METHODS: To identify the associations of CXCR5 and IL2RA gene polymorphisms with susceptibility to MS, we recruited 263 MS patients from the Han nationality and 138 from the Hui nationality as MS group and 284 healthy volunteers from the Han nationality and 156 from the Hui nationality as controls...
December 2018: Neurological Research
Fang Cui, Liuqing Sun, Jie Qiao, Jianmei Xiong, Yangang Zhao, Jianyong Li, Mao Li, Siyu Chen, Xusheng Huang
OBJECTIVES: Hereditary spastic paraplegias (HSP) is a heterogeneous group of inherited neurologic disorders with diversified clinical manifestations. The purpose of this study was to summarize the clinical manifestations of HSP by analyzing the clinical data of 56 HSP patients. METHODS: A total of 56 HSP patients treated in our hospital from January 2014 to March 2016 were included. Demographic and clinical characteristics of patients were collected. The severity of HSP was assessed by disease severity score...
December 2018: Neurological Research
Mehrnaz Moattari, Farahnaz Moattari, Gholamreza Kaka, Homa Mohseni Kouchesfehani, Seyed Homayoon Sadraie, Majid Naghdi, Korosh Mansouri
OBJECTIVE: Peripheral nerve injuries comprise significant portion of the nervous system injuries. Although peripheral nerves show some capacity of regeneration after injury, the extent of regeneration is not remarkable. The present study aimes to evaluate the regeneration of transected sciatic nerve by a therapeutic value of dexamethasone (DEX) associated with cell therapy (Cell) and biodegradable membrane (Mem) in rat. METHODS: Male Wistar rats (n = 42, 180-200g) were randomly divided into control (Ctrl), Membrane+ Cell, Mem, DEX, DEX+ Cell, DEX+ Mem and DEX+ Cell+ Mem groups...
December 2018: Neurological Research
Hiroko Ikeshima-Kataoka, Yutaka Matsui, Toshimitsu Uede
OBJECTIVES: Osteopontin (OPN) is an inflammatory cytokine inducer involved in cell proliferation and migration in inflammatory diseases or tumors. To investigate the function of OPN in astrocyte activation during brain injury, we compared OPN-deficient (OPN/KO) with wild-type (WT) mouse brains after stab wound injury and primary culture of astrocytes. METHODS: Primary cultures of astrocytes were prepared from either WT or OPN/KO postnatal mouse brains. Activation efficiency of astrocytes in primary culture was accessed using Western blotting by examining the protein levels of glial fibrillary acidic protein (GFAP) and tenascin-C (TN-C), which are markers for reactive astrocytes, following lipopolysaccharide (LPS) stimulation...
December 2018: Neurological Research
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