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Neurological Research

Yan-Chun Wang, Yao-Bing Zou, Jing Xiao, Cheng-de Pan, Si-de Jiang, Zong-Ju Zheng, Zong-Ren Yan, Kun-Yu Tang, Lang-Min Tan, Ming-Shan Tang
OBJECTIVE: Many studies have analyzed the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and Parkinson's disease (PD), which yield inconsistent results. This meta-analysis was designed to determine the possible association between the COMT Val158Met polymorphism and the risk of PD in different populations. METHODS: The PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure and Chinese Biology Medicine databases were used for literature searching up to May 2018...
January 15, 2019: Neurological Research
Joanna Kosacka, Katrin Woidt, Klaus V Toyka, Sabine Paeschke, Nora Klöting, Ingo Bechmann, Matthias Blüher, Joachim Thiery, Susann Ossmann, Petra Baum, Marcin Nowicki
INTRODUCTION: Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load. METHODS: Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months. RESULTS: We found intraepidermal nerve fiber degeneration in foot skin and low-grade neuropathic abnormalities including mildly slowed motor and compound sensory nerve conduction velocities and low-grade macrophage and T-cell infiltration without overt neuropathology in sciatic nerves of all ob/ob mice...
January 13, 2019: Neurological Research
Jean Carlos Debastiani, André Junior Santana, Lucinéia de Fátima Chasko Ribeiro, Rose Meire Costa Brancalhão, Gladson Ricardo Flor Bertolini
OBJECTIVE: To verify the action of sericin associated to swim exercise with overload, on sciatic nerve repair in Wistar rats, after 22 days of nerve compression. METHODS: Forty animals been composed of five groups: control, injury, injury-sericin, injury-swimming and injury-sericin-swimming. During the lesion procedure, sericin, in hydrolyzed form, applied directly to the injury in the injury-sericin and injury-sericin-swimming groups. Injury-swimming and injury-sericin-swimming groups underwent to 5 days per week for 3 weeks, with a 10% overload of the animal's body weight, and a weekly progressive evolution of swimming time, lasting 15, 20 and 25 min/day...
January 13, 2019: Neurological Research
Jianfeng Zheng, Rui Xu, Zongduo Guo, Xiaochuan Sun
OBJECTIVE: The risk of hemorrhagic events in small ruptured aneurysms remains unclear. Due to less arterial wall, small ruptured aneurysms may be correlated with massive bleeding and rebleeding. Therefore, it may contribute to treatment to evaluate the amount of bleeding and the risk of rebleeding in small ruptured aneurysms. METHODS: A retrospective cohort study of all consecutive patients with intracranial aneurysms admitted to our hospital from February 2013 to December 2017 was carried out...
January 13, 2019: Neurological Research
Michael King, Liam P Kelly, Elizabeth M Wallack, S M Mahmudul Hasan, Megan C Kirkland, Marie E Curtis, Tanaya Chatterjee, Jason McCarthy, Michelle Ploughman
OBJECTIVES: Our objectives were: 1) to determine whether maximal aerobic exercise increased serum neurotrophins in chronic stroke and 2) to determine the factors that predict resting and exercise-dependent levels. METHODS: We investigated the potential predictors of resting and exercise-dependent serum insulin-like growth factor-1 and brain-derived neurotrophic factor among 35 chronic stroke patients. Predictors from three domains (demographic, disease burden, and cardiometabolic) were entered into 4 separate stepwise linear regression models with outcome variables: resting insulin-like growth factor, resting brain-derived neurotrophic factor, exercise-dependent change in insulin-like growth factor, and exercise-dependent change brain-derived neurotrophic factor...
January 8, 2019: Neurological Research
Ming-Xing Liu, Jun Zhong, Lei Xia, Ning-Ning Dou, Shi-Ting Li
BACKGROUND: It is necessary to understand the mechanism of trigeminal neuralgia (TN) and hemifacial spasm (HFS) in order to seek for an effective noninvasive remedy. As previous studies implied that inflammatory cytokines induced by demyelination following the nerve injury may be the initiated factor causing neuropathic pain, we attempt to analyze the correlation between cytokines and these hyperactive cranial nerve disorders. METHOD: The consecutive patients whose diagnosis were confirmed by microvascular decompression surgery as primary TN or HFS caused by vascular compression and healthy volunteers between March and May 2018 in XinHua Hospital Shanghai JiaoTong University School of Medicine were recruited...
January 5, 2019: Neurological Research
Ezgi Yetim Arsava, Ethem Murat Arsava, Kader Karlı Oguz, Mehmet Akif Topcuoglu
OBJECTIVES: Occipital petalia is an anatomic description where one of the occipital lobes protrudes towards the contralateral side. Transverse sinus (TS) asymmetry might cause diagnostic challenges with regards to thrombotic or compressive pathologies involving these sinuses. In this study, we investigated the association between occipital petalia and TS hypoplasia on MRI studies. METHODS: In 264 subjects with no neurological complaints, occipital bending was determined on T1-weighted images based on the angulation of interhemispheric fissure between occipital lobes with respect to an imaginary midline...
January 2, 2019: Neurological Research
Chao Wu, Lan-De Xue, Lin-Wang Su, Jian-Li Xie, Huan Jiang, Xi-Jiao Yu, Hong-Mei Liu
OBJECTIVE: Neural stem cells (NSCs) are multipotent stem cells that generating various neural cells, including neurons, astrocytes and oligodendrocytes. This showed that NSCs is an ideal candidate in the application of neural disease treatment. In the current study, we established a simple and efficient method to promote the viability and induce the differentiation of NSCs by stimulating with magnesium. METHODS: The proliferation and differentiation of NSCs was determined by MTT assay and immunostaining...
December 30, 2018: Neurological Research
Qing-Fei Niu, Qiao-Ling Wang, Zhao-Xue Tong, Lei Tong, Xiao-Jie Tong
OBJECTIVES: To observe whether Graphene oxide (GO) can absorb vitamin B12 (VB12) and Decellularized scaffold - acellular nerve allograft (ANA) modified GO-VB12 promote the repair of ischiadic nervus defects in a rat model. METHODS: The adsorption of GO on vitamin and the optimum adsorption conditions were investigated by single factor experiment. The adsorption properties of the material were observed by scanning electron microscopy (SEM) and energy dispersive spectrometer (EDS) to determine the success of adsorption on VB12...
December 25, 2018: Neurological Research
Xiaolin Wang, Zhe Yu, Zi He, Qiang Zhang, Shengyuan Yu
OBJECTIVE AND METHOD: D-serine acts as an obligatory ligand for the glycine sites of N-methyl-D-aspartate receptors. To investigate its effect on head-facial pain, nociceptive behaviors of rats induced by electrical stimulation of the dura mater were observed after cerebroventricular infusion of D-serine. RESULTS: Rats in the D-serine infusion group showed significantly fewer nociceptive behaviors, including grooming and head flicking, than rats in the saline infusion group and control rats...
December 25, 2018: Neurological Research
Mehmet Esen, Hatice Aygun
AIM: Previous studies showed the existence of a relationship between epilepsy and depression. Duloxetine is a potent and selective inhibitor of serotonin and norepinephrine reuptake (SNRI) used in the treatment of the major depressive disorder. The aim of the present study was to investigate the effect of duloxetine on penicillin-induced epileptiform activity in an experimental rat model of acute partial epilepsy. METHOD: In this study, 35 male rats weighing 200-240 g were used...
December 24, 2018: Neurological Research
Angel F Farinas, Alonda C Pollins, Michael Stephanides, Dillon O'Neill, Salam Al-Kassis, Isaac V Manzanera Esteve, Juan M Colazo, Patrick R Keller, Timothy Rankin, Blair A Wormer, Christodoulos Kaoutzanis, Richard D Dortch, Wesley P Thayer
BACKGROUND: Diffusion tensor tractography (DTT) has recently been shown to accurately detect nerve injury and regeneration. This study assesses whether 7-tesla (7T) DTT imaging is a viable modality to observe axonal outgrowth in a 4 cm rabbit sciatic nerve injury model fixed by a reverse autograft (RA) surgical technique. METHODS: Transection injury of unilateral sciatic nerve (4 cm long) was performed in 25 rabbits and repaired using a RA surgical technique. Analysis of the nerve autograft was performed at 3, 6, and 11 weeks postoperatively and compared to normal contralateral sciatic nerve, used as control group...
December 24, 2018: Neurological Research
Nicole Elisabeth Ørsted Schultz, Henrik Hasseldam, Rune Skovgaard Rasmussen, Nina Vindegaard, Oskar McWilliam, Helle Klingenberg Iversen, Flemming Fryd Johansen
OBJECTIVE: In this clinical case-control study, we investigated statin treatment in stroke patients on a range of inflammatory effectors in peripheral blood. We focus on RhoA GTPase and its downstream effectors as a future inflammatory target in stroke treatment. METHODS: Data from 10 patients already on statins at stroke onset (Pre-S group) was compared with data from both 29 patients starting statin treatment right after stroke onset (Post-S group) and with 8 healthy controls...
December 21, 2018: Neurological Research
Suresh C Bokoliya, Shripad A Patil
OBJECTIVE: To evaluate transcervical and transsternal thymectomy benefits in large myasthenia gravis (MG) cohort. METHOD: We retrospectively evaluated MG patients (n = 184) who had undergone thymectomy between 2004 and 2015 at National Institute of Mental Health and Neurosciences, Bangalore (India). Myasthenia gravis foundation of America guidelines were followed to assess clinical outcome. Anti-acetylcholine receptors (AChR) antibodies, repetitive nerve stimulation (RNS) and Neostigmine tests were performed at pre and post-thymectomy stage...
December 21, 2018: Neurological Research
Ramazan Üstün, Peray Ayhan
OBJECTIVE: Peripheral nerve injury (PNI) is an important global health problem. Nerve Growth Factor (NGF) plays crucial role in the survival, growth, and maintenance of various neurons in the mammalian nervous system, human included. Hericium erinaceus (HE), an edible and medicinal mushroom, has been extensively studied for its neuroprotective properties. In this study, the neuroprotective and neurotogenic effects of HE and NGF were compared on mouse PNI model by using a laser microdissection technique...
December 20, 2018: Neurological Research
Ping Wang, Xinyan Li, Chaoming He, Yun Zhai, Hongwei Sun, Yu Zhang, Hong Wang, Yuna Wang, Jingbo Zhao, Ying Tang
OBJECTIVES: The relationship between hyperuricemia (HUA) and prognosis of acute ischemic stroke (AIS) is unclear. This prospective cohort study aims to evaluate potential value of HUA as a prognostic factor for AIS independent of diabetic status. METHODS: A total of 1041 consecutive patients aged from 25 to 96 with AIS were included. 340 (32.7%) had diabetes and 246 (23.6%) had HUA. Diabetic patients were stratified by gender or age. Multivariate logistic regression was used to analyse the association between HUA and prognosis of AIS...
December 11, 2018: Neurological Research
Anne Katrine Andreasen, Pernille Iversen, Lisbet Marstrand, Volkert Siersma, Hartwig Roman Siebner, Finn Sellebjerg
BACKGROUND: Fatigue in multiple sclerosis (MS) is a debilitating symptom and experienced by most patients. In recent studies investigating this phenomenon, the majority of patients had a relapsing-remitting disease course. METHODS: Patients with progressive MS participating in one of three treatment trials during a period from 2010 to 2014 were included. Fatigue was assessed with the Fatigue Scale for Motor and Cognitive Functions (FSMC) and patients were further examined with a cognitive test battery, including Symbol Digit Modalities Test (SDMT), and 3 T MRI with subsequent quantitative analyses of 13 cortical regions of interest, deep grey matter and lesion volume...
December 4, 2018: Neurological Research
Zhiyong Zhai, Juan Feng
BACKGROUND: Previous studies have shown the potential interactions between cerebrovascular diseases and microalbuminuria. However, the relationship between urine microalbumin and acute lacunar infarction caused by cerebral small vessel disease (CSVD) remains unknown. METHODS: The clinical data of 148 patients with acute lacunar infarction admitted to the Department of Neurology, Shengjing Hospital of China Medical University between April 2016 and April 2017 were analyzed...
November 26, 2018: Neurological Research
Katarina Dibdiakova, Simona Saksonova, Ivana Pilchova, Katarina Klacanova, Zuzana Tatarkova, Peter Racay
OBJECTIVES: We have investigated the impact of endoplasmic reticulum (ER) stress, which is often implicated in neurodegenerative diseases, on the expression of Hrd1, an E3 ubiquitin ligase that plays a central role in the process of ER-associated degradation (ERAD). METHODS: SH-SY5Y neuroblastoma cells, a frequently used model for studying neurotoxicity in dopaminergic neurons and the mechanisms of neurodegeneration associated with Parkinson's disease, and parental SK-N-SH cells were studied...
November 26, 2018: Neurological Research
Nour S Erekat
OBJECTIVES: Mechanisms underlying Purkinje cell (PC) death, which leads to many diseases in humans, are still poorly elucidated. Progressive PC degeneration occurs in shaker mutant rat due to an X-linked recessive mutation leading to gait ataxia and total-body tremors. Chemoablation of the inferior olive (IO) and olivocerebellar deafferentation temporally accelerated PC death from the natural 6-8 week time-course to 1-2 weeks in the shaker mutant rat. The present study posits that IO chemoablation leads to the accelerated and augmented upregulation of the executioner active caspase-3 that triggers apoptosis of at-risk PCs throughout the ordinary phenotypic manifestation of the shaker mutation...
November 21, 2018: Neurological Research
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