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Neurological Research

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https://www.readbyqxmd.com/read/28738762/effects-of-neuroserpin-on-clinical-outcomes-and-inflammatory-markers-in-chinese-patients-with-acute-ischemic-stroke
#1
Weiwen Wu, Tetsuya Asakawa, Qianghong Yang, Jun Zhao, Lixia Lu, Yunhe Luo, Ping Gong, Sha Han, Wei Li, Hiroki Namba, Liang Wang
OBJECTIVE: Neuroserpin (NSP) is known for its neuroprotective effects. The aim of this study was to investigate the relationship between NSP level and clinical outcomes and inflammatory markers in Chinese patients with acute ischemic stroke. METHODS: A total of 133 patients with acute cerebral infarction (ischemia group) and 44 controls were recruited. The modified Rankin Scale (mRS) was used to determine the functional outcome three months after onset. We investigated the relationship between serum NSP levels [on admission and a decrease in NSP levels (10 days after admission versus on admission)] and serum levels of several inflammatory markers...
July 24, 2017: Neurological Research
https://www.readbyqxmd.com/read/28738742/effects-of-erk1-2-kinases-inactivation-on-the-nigrostriatal-system-of-krushinsky-molodkina-rats-genetically-prone-to-audiogenic-seizures
#2
Nadezhda A Dorofeeva, Yuliya S Grigorieva, Liubov S Nikitina, Elena A Lavrova, Elizaveta V Nasluzova, Margarita V Glazova, Elena V Chernigovskaya
Recently, we demonstrated that inhibition of ERK1/2 activity by SL-327 treatment blocks seizure behavior in Krushinsky-Molodkina (KM) rats, which was mediated by altering of GABA and glutamate release mechanism in the hippocampus. Basal ganglia representing various subcortical cell groups play a significant role in the regulation of motor activity, including epileptiform seizures. OBJECTIVES:  To verify if nigrostriatal system could be also affected by SL-327 treatment we analyzed the expression of tyrosine hydroxylase, D1 and D2 dopamine receptors, NR2B subunit of NMDA receptor as well as vesicular glutamate transporter VGLUT2 and glutamic acid decarboxylases GAD65/67 in the striatum and substantia nigra of KM rats...
July 24, 2017: Neurological Research
https://www.readbyqxmd.com/read/28720038/neuroprotective-effect-of-g-14-humanin-on-global-cerebral-ischemia-reperfusion-by-activation-of-socs3-stat3-mcl-1-signal-transduction-pathway-in-rats
#3
Guangsheng Gao, Huaihai Fan, Xiaoying Zhang, Fusen Zhang, Haiyan Wu, Feng Qi, Lei Zhao, Yun Li
OBJECTIVE: Humanin (HN) has been identified to suppress neuron death. Gly(14)-HN (HNG), as a variant of HN, can decrease infarct volume after ischemia/reperfusion (I/R) injury. This study aimed to investigate the neuroprotective mechanism of HNG on global cerebral I/R (GI) in rats. METHODS: Rats were randomly divided into 13 groups: Sham group, GI groups and HNG groups. Both GI group and HNG groups included six time points (1, 3, 6, 12, 24, and 72 h). At 24 h after reperfusion, Nissl staining was used to observe positive neurons, and p-STAT3, MCL-1, SOCS3, Bax and Caspase-3 in different groups were detected by immunohistochemistry...
July 18, 2017: Neurological Research
https://www.readbyqxmd.com/read/28715936/selection-of-gait-parameters-for-differential-diagnostics-of-patients-with-de-novo-parkinson-s-disease
#4
Milica Djurić-Jovičić, Minja Belić, Iva Stanković, Saša Radovanović, Vladimir S Kostić
BACKGROUND: Gait disturbances are an integral part of clinical manifestations of Parkinson's disease (PD), even in the initial stages of the disease. Our goal was to identify the set of spatio-temporal gait parameters that bear the highest relevance for characterizing de novo PD patients. METHODS: Forty patients with de novo PD and forty healthy controls were recorded while walking over an electronic walkway in three different conditions: (1) base walking, (2) walking with an additional motor task, (3) walking with an additional mental task...
July 17, 2017: Neurological Research
https://www.readbyqxmd.com/read/28714326/spinal-cord-ischemia-reperfusion-causes-damage-of-neurocyte-by-inhibiting-rap2c
#5
Yong Qiao, Changliang Peng, Ji Li, Dongjin Wu, Xiuwen Wang
OBJECTIVE: To explore the mechanism of RAP2C participating in spinal cord ischemia-reperfusion injury (SCII). MATERIALS AND METHODS: mRNA expressions of miR-204 and RAP2C were measured by qRT-PCR. Protein level of RAP2C was detected by Western blot. Cell apoptosis in AGE1.HN and PC12 cells was detected by Annexin V/propidium iodide assay. The effect of miR-204 knockdown or overexpression on RAP2C expression was observed by luciferase assay. RESULTS: In this experimental research, RAP2C expression in SCII group was lower than control group, while miR-204 expression was higher...
July 16, 2017: Neurological Research
https://www.readbyqxmd.com/read/28701075/the-effect-of-orexin-a-on-motor-and-cognitive-functions-in-a-rat-model-of-parkinson-s-disease
#6
Zahra Hadadianpour, Farangis Fatehi, Fateme Ayoobi, Ayat Kaeidi, Ali Shamsizadeh, Iman Fatemi
OBJECTIVE:  The aim of this study was to evaluate the effect of orexin-A (OX-A) and the orexin-1 receptor antagonist SB-334867 (SB) on motor and cognitive functions in a rat model of Parkinson's disease. METHODS: Parkinson was induced by intracerebroventricular (i.c.v) injection of 6- hydroxydopamine (6-OHDA) (200 μg/rat). 72 h later, the treatment was initiated by i.c.v administration of SB (30 nmol/rat) and/or OX-A (0.3 nmol/rat) for 10 days. Motor functions were monitored using rotarod and hanging tests...
July 12, 2017: Neurological Research
https://www.readbyqxmd.com/read/28701072/a-novel-biomimetic-composite-substitute-of-plla-gelatin-nanofiber-membrane-for-dura-repairing
#7
Kunxue Deng, Yaya Yang, Yiquan Ke, Chengyi Luo, Man Liu, Yuting Deng, Quan Tian, Yuyu Yuan, Tun Yuan, Tao Xu
OBJECTIVE: Biomimetic design will significantly improve growth and regeneration of dural cells and tissue for better repairing effects and fewer complications in repairing the native dura. This study designed a novel composite, biomimetic substitute based on the characteristics of native dura extracellular matrix. METHODS AND RESULTS: This substitute is expected to rapidly induce cell adhesion, migration, and fast regeneration of neotissue. The material characteristics (contact angle, surface charge, and zeta potential were evaluated), in vitro biological characteristics (cell stretch, connections between cells, cell proliferation) and in vivo tissue regeneration capability of this substitute were evaluated, compared to those of collagen dura substitute, the mostly used dura substitute...
July 12, 2017: Neurological Research
https://www.readbyqxmd.com/read/28689485/therapeutic-ultrasound-after-sciatic-nerve-compression-of-wistar-rats
#8
Gladson Ricardo Flor Bertolini, Jhenifer Karvat, Camila Mayumi Martin Kakihata, Lucinéia de Fátima Chasko Ribeiro, Rose Meire Costa Brancalhão
OBJECTIVES: The present study analyzed the effect of therapy with therapeutic ultrasound on the sciatic nerve after compression injury, comparing two similar doses of SATA. METHODS: In total, 32 Wistar rats were used, divided into the following groups: CG - control; IG - compression injury of the sciatic nerve; IGCU - injury and continuous ultrasound; and IGPU - injury and 20% pulsed ultrasound. The treatment with ultrasound started on the 3rd postoperative day, with a frequency of 1 MHz, 0...
July 8, 2017: Neurological Research
https://www.readbyqxmd.com/read/28683603/high-nonfasting-triglyceride-concentrations-predict-good-outcome-following-acute-ischaemic-stroke
#9
Kyusik Kang, Jung-Ju Lee, Jong-Moo Park, Ohyun Kwon, Sang Won Han, Byung Kun Kim
OBJECTIVES: A higher fasting triglyceride (TG) concentration has been associated with better functional outcomes after stroke. Recent observational studies have found that nonfasting TG concentrations predict incident stroke better than fasting concentrations. The aim of the study was to investigate the relationship between fasting and nonfasting serum TG concentrations versus 3-month functional activity and mortality among patients with acute ischaemic stroke. METHODS: This was a retrospective study based on prospectively collected data...
July 6, 2017: Neurological Research
https://www.readbyqxmd.com/read/28679344/survey-based-assessment-of-the-relationship-between-cognitive-impairment-and-mentally-stimulating-activity-in-multiple-sclerosis
#10
Briana C Prager, Amy S Nowacki, Devon S Conway
OBJECTIVES: Cognitive impairment (CI) is a common and potentially debilitating component of the disease course in multiple sclerosis (MS). However, therapeutic options remain limited. It is unknown whether cognitively enriching activities reduce the burden of CI in patients with MS, as is found in other neurologic diseases affecting cognition. The aim of this study was to determine whether participation in cognitively enriching activities decreased self-reported CI in MS patients. METHODS: CI and activity levels were reported through electronic surveys completed by MS patients at the Cleveland Clinic...
July 5, 2017: Neurological Research
https://www.readbyqxmd.com/read/28675964/postoperative-blood-pressure-variability-exerts-an-influence-on-clinical-outcome-after-coil-embolization-of-ruptured-intracranial-aneurysms
#11
Bin Xu, Qiuhong Ji, Yunfeng Zhang, Lihua Shen, Maohong Cao, Kefu Cai
OBJECTIVE: The present study was conducted to evaluate the effect of postoperative blood pressure (BP) variability on functional outcome in patients after coil embolization of ruptured aneurysms. METHODS: The authors retrospectively reviewed their database of patients undergoing endovascular coiling to treat subarachnoid hemorrhage (SAH) between November 2011 and December 2014. BP values were recorded every 2 hours in the initial 24 hours after endovascular obliteration of ruptured aneurysms...
July 4, 2017: Neurological Research
https://www.readbyqxmd.com/read/28604272/the-use-of-sheep-as-a-model-for-studying-peripheral-nerve-regeneration-following-nerve-injury-review-of-the-literature
#12
Camila Cardoso Diogo, José Arthur Camassa, José Eduardo Pereira, Luís Maltez da Costa, Vítor Filipe, Pedro Alexandre Couto, Stefano Geuna, Ana Colette Maurício, Artur Severo Varejão
Peripheral nerve injury and regeneration is a challenging scientific field with relevant clinical implications. Most peripheral nerve regeneration studies have been mainly carried out on rodents. However, it is important to note that the validity of the rodent as a model to study nerve injury and regeneration and translate these results into clinical practice has been questioned by several researchers. To overcome this problem, some investigators have used companion animals and large animal species as models for experimental peripheral nerve regeneration studies...
June 11, 2017: Neurological Research
https://www.readbyqxmd.com/read/28592211/calmodulin-like-skin-protein-is-downregulated-in-human-cerebrospinal-fluids-of-alzheimer-s-disease-patients-with-apolipoprotein-e4-a-pilot-study-using-postmortem-samples
#13
Yuichi Hashimoto, Takahiko Umahara, Haruo Hanyu, Toshihiko Iwamoto, Masaaki Matsuoka
OBJECTIVE: Calmodulin-like skin protein (CLSP) is a secreted peptide that inhibits neuronal cell death, linked to Alzheimer's disease (AD), by binding to the heterotrimeric humanin receptor and activating an intracellular survival pathway. CLSP is only expressed in skin keratinocytes and related epithelial cells, circulates in the blood stream, and passes the blood-cerebrospinal fluid (CSF) barrier. In the current study, we addressed the issues as to whether CLSP functions in the central nervous system and whether the concentration of CLSP is reduced in the CSFs of AD patients...
June 7, 2017: Neurological Research
https://www.readbyqxmd.com/read/28566060/topical-application-of-the-hematostatic-agent-surgiflo%C3%A2-could-attenuate-brain-injury-in-experimental-tbi-mice
#14
Dewei Guo, Dongpeng Li, Jinghong Li, Yunfeng Li, Xiang Hu, Fangxia Guan, Bo Yang
OBJECT: The pathologies resulting from traumatic brain injury (TBI) have been thoroughly studied, but rarely have the effects of bleeding and coagulation in the early stage of TBI been considered. In this study, we investigated the effects of topical Surgiflo(®) application on brain injury in experimental TBI mice using S100β, MAP-2 and mNSS scores. METHODS: TBI was induced by modified weight drop injury in male C57BL/6 mice. The mice were then randomly divided into (i) the sham group, (ii) TBI mice applied with saline (vehicle), and (iii) TBI mice applied with Surgiflo(®) in the same volume...
May 31, 2017: Neurological Research
https://www.readbyqxmd.com/read/28562233/relationship-of-phosphodiesterase-4d-pde4d-gene-polymorphisms-with-risk-of-ischemic-stroke-a-hospital-based-case-control-study
#15
Amit Kumar, Shubham Misra, Pradeep Kumar, Ram Sagar, Arti Gulati, Kameshwar Prasad
BACKGROUND: Stroke remains a leading cause of death and disability worldwide. Ischemic stroke (IS) accounts for around 80-85% of total stroke and is a complex polygenic multi-factorial disorder which is affected by a complex combination of vascular, environmental, and genetic factors. OBJECTIVE: The study was conducted with an aim to examine the relationship of single nucleotide polymorphisms (SNPs) of PDE4D (T83C, C87T, and C45T) gene with increasing risk of IS in patients in North Indian population...
May 31, 2017: Neurological Research
https://www.readbyqxmd.com/read/28552032/the-role-of-microrna-in-neuronal-inflammation-and-survival-in-the-post-ischemic-brain-a-review
#16
William A Li, Aslan Efendizade, Yuchuan Ding
Each year, more than 790 000 people in the United States suffer from a stroke. Although progress has been made in diagnosis and treatment of ischemic stroke (IS), new therapeutic interventions to protect the brain during an ischemic insult is highly needed. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression post-transcriptionally. Growing evidence suggests that miRNAs have a profound impact on ischemic stroke progression and are potential targets of novel treatments. Notably, inflammatory pathways play an important role in the pathogenesis of ischemic stroke and its pathophysiologic progression...
May 27, 2017: Neurological Research
https://www.readbyqxmd.com/read/28531358/vitamin-b1-deficiency-in-patients-with-postural-tachycardia-syndrome-pots
#17
Svetlana Blitshteyn
OBJECTIVE: POTS is a heterogeneous disorder of the autonomic nervous system that can result from multiple etiologies. An increased prevalence of vitamin B12, vitamin D 25-OH and iron deficiencies has been observed in patients with POTS. This study examined the prevalence of vitamin B1 deficiency and assessed response to vitamin B1 supplementation in the deficient POTS patients. METHODS AND RESULTS: Medical records of 65 consecutive patients with POTS evaluated at our clinic were reviewed...
May 21, 2017: Neurological Research
https://www.readbyqxmd.com/read/28502217/hippocampal-low-frequency-stimulation-inhibits-afterdischarge-and-increases-gaba-a-receptor-expression-in-amygdala-kindled-pharmacoresistant-epileptic-rats
#18
Guofeng Wu, Likun Wang, Zhen Hong, Siying Ren, Feng Zhou
OBJECTIVE: The purpose of the present study was to observe the effects of hippocampal low-frequency stimulation (Hip-LFS) on amygdala afterdischarge and GABA (A) receptor expression in pharmacoresistant epileptic (PRE) rats. METHODS: A total of 110 healthy adult male Wistar rats were used to generate a model of epilepsy by chronic stimulation of the amygdala. Sixteen PRE rats were selected from 70 amygdala-kindled rats by testing their response to Phenytoin and Phenobarbital, and they were randomly assigned to a pharmacoresistant stimulation group (PRS group, 8 rats) or a pharmacoresistant control group (PRC group, 8 rats)...
May 14, 2017: Neurological Research
https://www.readbyqxmd.com/read/28502216/a-retrospective-analysis-of-postoperative-recurrence-of-septated-chronic-subdural-haematoma-endoscopic-surgery-versus-burr-hole-craniotomy
#19
Kaixuan Yan, Heng Gao, Xinmin Zhou, Wei Wu, Weidong Xu, Yu Xu, Kai Gong, Xinchen Xue, Qipin Wang, Hanrong Na
OBJECTIVE: To identify the factors associated with Septated chronic subdural haematoma (sCSDH) recurrence and to compare the advantages and disadvantages of burr hole craniotomy (BHC) and endoscopic surgery (ES) with respect to preventing sCSDH recurrence. METHODS: A total of 76 consecutive patients with sCSDH underwent BHC or ES in our institution. Their clinical data were retrospectively analysed to identify the factors associated with sCSDH recurrence and to evaluate the effectiveness of BHC and ES with respect to preventing sCSDH recurrence...
May 13, 2017: Neurological Research
https://www.readbyqxmd.com/read/28490273/corrigendum
#20
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May 11, 2017: Neurological Research
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