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Neurological Research

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https://www.readbyqxmd.com/read/28918702/anterior-thalamic-nuclei-deep-brain-stimulation-reduces-disruption-of-the-blood-brain-barrier-albumin-extravasation-inflammation-and-apoptosis-in-kainic-acid-induced-epileptic-rats
#1
Ying-Chuan Chen, Guan-Yu Zhu, Xiu Wang, Lin Shi, Ting-Ting Du, De-Feng Liu, Yu-Ye Liu, Yin Jiang, Xin Zhang, Jian-Guo Zhang
Objective The therapeutic efficacy of anterior thalamic nuclei deep brain stimulation (ATN-DBS) against seizures has been largely accepted; however, the effects of ATN-DBS on disruption of the blood-brain barrier (BBB), albumin extravasation, inflammation and apoptosis still remain unclear. Methods Rats were distributed into four treatment groups: physiological saline (PS, N = 12), kainic acid (KA, N = 12), KA-sham-DBS (N = 12) and KA-DBS (N = 12). Seizures were monitored using video-electroencephalogram (EEG)...
September 18, 2017: Neurological Research
https://www.readbyqxmd.com/read/28889791/additional-resective-surgery-after-the-failure-of-initial-surgery-in-patients-with-intractable-epilepsy
#2
Masafumi Fukuda, Hiroshi Masuda, Hiroshi Shirozu, Yosuke Ito, Yoko Nakayama, Takefumi Higashijima, Yukihiko Fujii
Objectives There are three conceivable reasons for the failure of resective surgery for intractable epilepsy: incomplete resection of the epileptogenic zone including or overlapping with eloquent area (group A); incorrect determination of the epileptogenic zone prior to the first surgery (group B); and the development of a new epileptic focus after the first surgery (group C). We examined the relationship between the reason for failure of initial surgery and patient outcomes after repeated surgical resection...
September 11, 2017: Neurological Research
https://www.readbyqxmd.com/read/28885111/effects-of-different-montages-of-transcranial-direct-current-stimulation-on-the-risk-of-falls-and-lower-limb-function-after-stroke
#3
Suellen Marinho Andrade, José Jamacy de Almeida Ferreira, Thatiana Silva Rufino, Germana Medeiros, Jader Duarte Brito, Michele Alexandre da Silva, Raquel de Negreiros Moreira
BACKGROUND: Stroke is associated with high rates of falling and severe impairment of lower limb in patients who survive. OBJECTIVE: The aim of this study was to analyze the effectiveness of different montages of transcranial direct current stimulation (tDCS) on reducing falls and on lower limb function after acute stroke. METHODS: Sixty participants with acute stroke were randomly allocated into four groups with different electrode's setups: anodal, cathodal, bilateral and sham tDCS...
September 8, 2017: Neurological Research
https://www.readbyqxmd.com/read/28836485/the-vascularization-pattern-of-acellular-nerve-allografts-after-nerve-repair-in-sprague-dawley-rats
#4
Zhaowei Zhu, Yanyan Huang, Xiaoyan Zou, Canbin Zheng, Jianghui Liu, Longhai Qiu, Bo He, Qingtang Zhu, Xiaolin Liu
OBJECTIVE: We have demonstrated that angiogenesis in acellular nerve allografts (ANAs) can promote neuroregeneration. The present study aimed to investigate the microvascular regeneration pattern of ANAs in Sprague-Dawley (SD) rats. METHODS: Sixty male SD rats were randomly divided into an autologous group and a rat acellular nerve allograft group (rANA), and 10-mm sciatic nerve defects were induced in these rats. On the 7th, 14th and 21st days after surgery, systemic perfusion with Evans Blue (EB) or lead oxide was performed on the rats through carotid intubation...
August 24, 2017: Neurological Research
https://www.readbyqxmd.com/read/28830306/epigenetic-approach-to-early-onset-parkinson-s-disease-low-methylation-status-of-snca-and-park2-promoter-regions
#5
Isil Ezgi Eryilmaz, Gulsah Cecener, Sevda Erer, Unal Egeli, Berrin Tunca, Mehmet Zarifoglu, Bulent Elibol, Ayse Bora Tokcaer, Esen Saka, Meltem Demirkiran, Cenk Akbostanci, Okan Dogu, Beril Colakoglu, Gulay Kenangil, Hakan Kaleagasi
Background and aim The effect of epigenetic modifications in the genes related to Parkinson's disease (PD) is still unclear. In the present study, we investigated methylation status of SNCA and PARK2 genes in patients with early-onset Parkinson's disease (EOPD). Materials and methods The promoter region methylation status of SNCA and PARK2 genes was evaluated by methylation specific-PCR (MSP) in 91 patients with EOPD and 52 healthy individuals. Results The methylation of SNCA and PARK2 promoter regions were significantly lower in EOPD patients compared to the control group (P = 0...
August 22, 2017: Neurological Research
https://www.readbyqxmd.com/read/28829278/glucose-6-phosphatase-%C3%AE-participates-in-dopaminergic-differentiation
#6
Jing Chen, Ting Wang, Xiao-Yan Zhou, Chuan-Xi Tang, Dian-Shuai Gao
OBJECTIVE:  Induction of dopaminergic (DA) differentiation is a cell-based therapy for Parkinson's disease (PD). Here, we explore the key factors of DA differentiation with a focus on glucose-6-phosphatase (G6Pase), a marker enzyme for the endoplasmic reticulum (ER) associated with cell differentiation. METHODS:  We cultured SH-SY5Y human neuroblastoma cells, a model system for PD research, and added glial cell-derived neurotrophic factor (GDNF; 25, 50, or 100 ng/ml) to stimulate differentiation...
August 22, 2017: Neurological Research
https://www.readbyqxmd.com/read/28828964/clinical-nutrition-and-gastrointestinal-dysfunction-in-critically-ill-stroke-patients
#7
Robert Patejdl, Matthias Kästner, Stephan Kolbaske, Matthias Wittstock
Background Data on the epidemiology and risk factors of altered gastrointestinal motility (AGIM) is virtually lacking for patients suffering from non-traumatic neurologic diseases and stroke. This study investigated whether patterns of AGIM differ between patients with stroke and other severe acute brain diseases. Methods Clinical records of stroke and non-stroke patients treated at a neurological intensive care unit (ICU) were reviewed at day 1-5 and at day 10 after admission. The data was analyzed for the course of enteral/parenteral nutrition and for and for signs and symptoms of gastrointestinal dysfunction...
August 22, 2017: Neurological Research
https://www.readbyqxmd.com/read/28828931/post-stroke-depression-different-characteristics-based-on-follow-up-stage-and-gender-a-cohort-perspective-study-from-mainland-china
#8
Zixuan Wang, Meifang Zhu, Zhaoping Su, Boyuan Guan, Anxin Wang, Yongjun Wang, Ning Zhang, Chunxue Wang
BACKGROUND: Post-stroke depression (PSD) is a common and important comorbidity in patients after stroke. It negatively impacts stroke survivors' outcomes. Plenty of studies have investigated risk factors for PSD, especially sex differences. However, the results remain inconsistent. In this study, we explored the prevalence and risk factors for PSD both in the acute phase and the chronic phase of stroke, emphasizing on the impact of gender in PSD. METHODS: About 1094 patients with first-ever ischemic stroke were included in the study...
August 22, 2017: Neurological Research
https://www.readbyqxmd.com/read/28828929/prognostic-value-of-serum-thioredoxin-levels-in-ischemic-stroke
#9
Tieer Yu, Wanli Zhang, Yuanshao Lin, Qian Li, Jie Xue, Zhengyi Cai, Yifan Cheng, Bei Shao
OBJECTIVES: Thioredoxin (Trx) is one of significant antioxidative molecules to diminish oxidative stress. Current evidence suggests that Trx is a potent antioxidant with cytoprotective functions. The aim of our study was to investigate specifically the association between serum Trx levels and acute ischemic stroke (AIS) patients. METHODS: 198 AIS patients and 75 controls were enrolled to the study. Serum Trx levels were measured using an enzyme-linked immunosorbent assay (ELISA)...
August 22, 2017: Neurological Research
https://www.readbyqxmd.com/read/28816099/sex-differences-of-steroid-receptor-coactivator-1-expression-after-spinal-cord-injury-in-mice
#10
Jiayu Xiao, Jiqiang Zhang, Yangang Zhao, Wenjie Huang, Zhikai Guo, Bingyin Su, Qiang Guo
OBJECTIVE: The neural functional recovery of female is often better than that of male after spinal cord injury (SCI). Evidences show that estrogen can attenuate inflammation and promote the neural survival and regeneration after SCI. SRC-1 is an essential initiation factor for the estrogen-regulated target gene transcription and plays a key role in regulating estrogen activity. However, it is not known whether and how SRC-1 mediates the neural regeneration promoted by estrogen after SCI...
August 17, 2017: Neurological Research
https://www.readbyqxmd.com/read/28814157/the-role-and-mechanism-of-glutamic-nmda-receptor-in-the-mechanical-hyperalgesia-in-diabetic-rats
#11
Jin Wang, Zhaohui Sun, Yuzhao Wang, Huisheng Wang, Yuan Guo
OBJECTIVES: Some studies have shown that painful neuropathy is a common and costly complication of both type 1 and type 2 diabetes mellitus, and glutamate is involved in the process although the mechanisms are not clear. The purpose of the present study was to investigate the effect of N-methyl-D-aspartate (NMDA) receptor on mechanical hyperalgesia in diabetic rats and the possible mechanism. METHODS: Diabetic rat model was established by intraperitoneal injection of streptozotocin (STZ, 1%, 70 mg/kg) once, and evaluated by the change in the fasting blood glucose...
August 17, 2017: Neurological Research
https://www.readbyqxmd.com/read/28791919/the-study-of-memory-and-executive-dysfunction-in-patients-infected-with-helicobacter-pylori
#12
Farzaneh Rezvani, Mohammad Sayadnasiri, Omid Rezaei
Background Infectious agents are considered as potential causes of Alzheimer's disease. Recently, evidence of a high prevalence of Helicobacter pylori (H. pylori) infection in patients with Alzheimer's disease has been observed. The aim of this study was to investigate memory and executive function in H. pylori positive persons not suffering from Alzheimer's or other marked cognitive disorders. Methods This is a cross-sectional study. A total 140 participants were selected using purposive sampling from the patients within the age group of 18-60 years old at Fayyaz Bakhsh Hospital, Tehran in spring 2016...
August 9, 2017: Neurological Research
https://www.readbyqxmd.com/read/28782464/nimodipine-activates-neuroprotective-signaling-events-and-inactivates-autophages-in-the-vcid-rat-hippocampus
#13
Ming Hu, Zhijuan Liu, Peiyuan Lv, Hebo Wang, Yifei Zhu, Qianqian Qi, Jing Xu, Lei Gao
BACKGROUND: Autophagy and phosphatidylinositol 3-kinase (PI3K)/Akt kinase pathways are implicated in cognitive decline associated with cerebrovascular lesions. This decline is reflected in the concept of vascular cognitive impairment and dementia (VCID). However, the underlying molecular mechanism and specific details regarding these types of cognitive deficits induced by chronic brain hypoperfusion have not been elucidated. METHODS: We designed a method to evaluate these mechanisms...
August 7, 2017: Neurological Research
https://www.readbyqxmd.com/read/28782435/rufinamide-pretreatment-attenuates-ischemia-reperfusion-injury-in-the-gerbil-hippocampus
#14
Chan Woo Park, Tae-Kyeong Lee, Jeong Hwi Cho, In Hye Kim, Jae-Chul Lee, Bich-Na Shin, Ji Hyeon Ahn, Sung Koo Kim, Myoung Cheol Shin, Taek Geun Ohk, Jun Hwi Cho, Moo-Ho Won, Young Joo Lee, Jeong Yeol Seo, Joon Ha Park
OBJECTIVES: Rufinamide, a voltage-gated sodium channel (VGSC) blocker, is widely used for the clinical treatment of seizures associated with Lennox-Gastaut syndrome. Previous studies have demonstrated that VGSC blockers have neuroprotective properties against ischemic damage following experimental cerebral ischemia. However, protective effects of rufinamide against cerebral ischemic insults have not been addressed. Therefore, in the present study, we firstly examined neuroprotective effects of rufinamide using a gerbil model of transient global cerebral ischemia...
August 7, 2017: Neurological Research
https://www.readbyqxmd.com/read/28749740/the-role-of-high-sensitivity-c-reactive-protein-levels-in-functional-outcomes-in-patients-with-large-artery-atherosclerosis-and-small-artery-occlusion
#15
Dongzhe Hou, Ji Liu, Ren Feng, Yuan Gao, Yajing Wang, Jialing Wu
BACKGROUND: High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker that is associated with the outcomes of ischemic stroke. However, the role of hs-CRP levels in the functional outcomes after large-artery atherosclerosis (LAA) and small-artery occlusion (SAO) is poorly understood. METHODS: We recruited 1299 patients diagnosed as having LAA and 453 patients diagnosed as having SAO from 1 January 2009 to 31 December 2013, from the Department of Neurology, Tianjin Huanhu Hospital...
July 27, 2017: Neurological Research
https://www.readbyqxmd.com/read/28743230/cart-modulates-beta-amyloid-metabolism-associated-enzymes-and-attenuates-memory-deficits-in-app-ps1-mice
#16
Kailin Yin, Jiali Jin, Xiaolei Zhu, Linjie Yu, Sulei Wang, Lai Qian, Lijuan Han, Yun Xu
INTRODUCTION: Cocaine- and amphetamine-regulated transcript (CART) peptide has been demonstrated to exert neuroprotective effects in stroke and some neurodegeneration diseases. In current study, we investigated the protective effects and underlying mechanisms of CART in APP/PS1 mice. METHODS: The protein levels of CART, soluble Aβ1-40 and Aβ1-42 were measured in the hippocampus of APP/PS1 mice by enzyme-linked immunosorbent assay. We determined the mRNA and protein levels of Aβ metabolism-associated enzymes including neprilysin (NEP), insulin-degrading enzyme (IDE), receptor for advanced glycation end products (RAGE), and low-density lipoprotein receptor-related protein 1 (LRP-1) in the hippocampus of APP/PS1 mice using real-time PCR and western blotting...
July 25, 2017: Neurological Research
https://www.readbyqxmd.com/read/28738762/effects-of-neuroserpin-on-clinical-outcomes-and-inflammatory-markers-in-chinese-patients-with-acute-ischemic-stroke
#17
Weiwen Wu, Tetsuya Asakawa, Qianghong Yang, Jun Zhao, Lixia Lu, Yunhe Luo, Ping Gong, Sha Han, Wei Li, Hiroki Namba, Liang Wang
OBJECTIVE: Neuroserpin (NSP) is known for its neuroprotective effects. The aim of this study was to investigate the relationship between NSP level and clinical outcomes and inflammatory markers in Chinese patients with acute ischemic stroke. METHODS: A total of 133 patients with acute cerebral infarction (ischemia group) and 44 controls were recruited. The modified Rankin Scale (mRS) was used to determine the functional outcome three months after onset. We investigated the relationship between serum NSP levels [on admission and a decrease in NSP levels (10 days after admission versus on admission)] and serum levels of several inflammatory markers...
July 24, 2017: Neurological Research
https://www.readbyqxmd.com/read/28738742/effects-of-erk1-2-kinases-inactivation-on-the-nigrostriatal-system-of-krushinsky-molodkina-rats-genetically-prone-to-audiogenic-seizures
#18
Nadezhda A Dorofeeva, Yuliya S Grigorieva, Liubov S Nikitina, Elena A Lavrova, Elizaveta V Nasluzova, Margarita V Glazova, Elena V Chernigovskaya
Recently, we demonstrated that inhibition of ERK1/2 activity by SL-327 treatment blocks seizure behavior in Krushinsky-Molodkina (KM) rats, which was mediated by altering of GABA and glutamate release mechanism in the hippocampus. Basal ganglia representing various subcortical cell groups play a significant role in the regulation of motor activity, including epileptiform seizures. OBJECTIVES:  To verify if nigrostriatal system could be also affected by SL-327 treatment we analyzed the expression of tyrosine hydroxylase, D1 and D2 dopamine receptors, NR2B subunit of NMDA receptor as well as vesicular glutamate transporter VGLUT2 and glutamic acid decarboxylases GAD65/67 in the striatum and substantia nigra of KM rats...
July 24, 2017: Neurological Research
https://www.readbyqxmd.com/read/28720038/neuroprotective-effect-of-g-14-humanin-on-global-cerebral-ischemia-reperfusion-by-activation-of-socs3-stat3-mcl-1-signal-transduction-pathway-in-rats
#19
Guangsheng Gao, Huaihai Fan, Xiaoying Zhang, Fusen Zhang, Haiyan Wu, Feng Qi, Lei Zhao, Yun Li
OBJECTIVE: Humanin (HN) has been identified to suppress neuron death. Gly(14)-HN (HNG), as a variant of HN, can decrease infarct volume after ischemia/reperfusion (I/R) injury. This study aimed to investigate the neuroprotective mechanism of HNG on global cerebral I/R (GI) in rats. METHODS: Rats were randomly divided into 13 groups: Sham group, GI groups and HNG groups. Both GI group and HNG groups included six time points (1, 3, 6, 12, 24, and 72 h). At 24 h after reperfusion, Nissl staining was used to observe positive neurons, and p-STAT3, MCL-1, SOCS3, Bax and Caspase-3 in different groups were detected by immunohistochemistry...
July 18, 2017: Neurological Research
https://www.readbyqxmd.com/read/28715936/selection-of-gait-parameters-for-differential-diagnostics-of-patients-with-de-novo-parkinson-s-disease
#20
Milica Djurić-Jovičić, Minja Belić, Iva Stanković, Saša Radovanović, Vladimir S Kostić
BACKGROUND: Gait disturbances are an integral part of clinical manifestations of Parkinson's disease (PD), even in the initial stages of the disease. Our goal was to identify the set of spatio-temporal gait parameters that bear the highest relevance for characterizing de novo PD patients. METHODS: Forty patients with de novo PD and forty healthy controls were recorded while walking over an electronic walkway in three different conditions: (1) base walking, (2) walking with an additional motor task, (3) walking with an additional mental task...
July 17, 2017: Neurological Research
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