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Neurological Research

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https://www.readbyqxmd.com/read/29297273/circulating-levels-of-interleukin-17a-tumor-necrosis-factor-alpha-interleukin-18-interleukin-10-and-cognitive-performance-of-patients-with-relapsing-remitting-multiple-sclerosis
#1
Anastasiya G Trenova, Georgi S Slavov, Milena N Draganova-Filipova, Nonka G Mateva, Mariya G Manova, Lyuba D Miteva, Spaska A Stanilova
Multiple sclerosis (MS) is associated with cytokine imbalance and high rate (40-70%) of cognitive impairment. The objective of this study is to investigate the relationship between serum concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-17A, IL-18, IL-10, and cognitive performance in patients with relapsing-remitting MS (RRMS). Methods The study comprised 159 patients with RRMS (mean age 40.08 ± 8.48 years) in remission phase and 86 age-, gender-, and education-matched healthy controls...
January 3, 2018: Neurological Research
https://www.readbyqxmd.com/read/29291703/electroencephalographic-changes-using-virtual-reality-program-technical-note-condensed-title-a-study-using-a-mobile-eeg-device
#2
Síria Monyelle Silva de Oliveira, Candice Simões Pimenta de Medeiros, Thaiana Barbosa Ferreira Pacheco, Nathalia Priscilla Oliveira Silva Bessa, Fernanda Gabrielle Mendonça Silva, Nathália Stéphany Araújo Tavares, Isabelle Ananda Oliveira Rego, Tania Fernandes Campos, Fabrícia Azevedo da Costa Cavalcanti
The aim of the study was to describe the technique of an electroencephalographic (EEG) assessment using the Emotiv EPOC® during the performance of a virtual reality motor task and compare theta, alpha, beta and gamma power frequencies between left and right hemispheres. This is technical note in which 9 healthy young subjects were submitted to an evaluation with Emotiv EPOC® during the Nintendo® Wii 'Basic Step' virtual game using the Wii Balance Board (WBB) on a support 13 centimeters high. The Wilcoxon statistical test was applied and pairing between the cerebral hemispheres was performed...
January 1, 2018: Neurological Research
https://www.readbyqxmd.com/read/29191115/focal-neurons-another-source-of-vascular-endothelial-growth-factor-in-brain-arteriovenous-malformation-tissues
#3
Pengchen Li, Longbo Zhang, Deshun Chen, Ming Zeng, Fenghua Chen
Background Brain arteriovenous malformations (bAVMs) are devastating, hemorrhage-prone, cerebrovascular entities characterized by well-defined feeding arteries, draining veins, and the absence of a capillary bed. The endothelial cells that comprise bAVMs exhibit a loss of arterial and venous specification. The role of abnormal angiogenesis in the formation and progression of bAVMs is still unclear. This study aimed to investigate the expression of vascular endothelial growth factor (VEGF) in neurons and glial cells in bAVMs to try to uncover the multiple cell origin of VEGF...
November 30, 2017: Neurological Research
https://www.readbyqxmd.com/read/29173125/time-series-analysis-variation-of-anti-acetylcholine-receptor-antibody-titer-in-myasthenia-gravis-is-related-to-incidence-of-mycoplasma-pneumoniae-and-influenza-virus-infections
#4
Kazuo Iwasa, Hiroaki Yoshikawa, Tsuyoshi Hamaguchi, Kenji Sakai, Moeko Shinohara-Noguchi, Miharu Samuraki, Kazuya Takahashi, Daisuke Yanase, Kenjiro Ono, Chiho Ishida, Mitsuhiro Yoshita, Hiroyuki Nakamura, Masahito Yamada
Objectives The exacerbating factors of myasthenia gravis (MG) are unknown. However, it has been speculated that infections may play a role in disease progression. Methods We calculated the adjusted anti-acetylcholine receptor antibody (Adj-AChR-Ab) titers (range, 0-1) in 58 MG patients between 2006 and 2012. We determined the relationship between Adj-AChR-Ab titer and infection incidence. Results A cross-correlation function (CCF) analysis of Adj-AChR-Ab titer and incidence of Mycoplasma pneumoniae (M. pneumoniae) (r = 0...
November 24, 2017: Neurological Research
https://www.readbyqxmd.com/read/29168669/awake-craniotomy-versus-craniotomy-under-general-anesthesia-for-the-surgical-treatment-of-insular-glioma-choices-and-outcomes
#5
B Y Gravesteijn, M E Keizer, A J P E Vincent, J W Schouten, R J Stolker, M Klimek
OBJECTIVE: To investigate differences in outcomes in patients who underwent surgery for insular glioma using an awake craniotomy (AC) vs. a craniotomy under general anesthesia (GA). METHODS: Data from patients treated at our hospital between 2005 and 2015 were analyzed retrospectively. The preoperative, intraoperative, postoperative, and longer term follow-up characteristics and outcomes of patients who underwent surgery for primary insular glioma using either an AC or GA were compared...
November 23, 2017: Neurological Research
https://www.readbyqxmd.com/read/29168666/diagnostic-methods-used-in-searching-for-markers-of-atrophy-in-patients-with-multiple-sclerosis
#6
Przemyslaw Puz, Arkadiusz Steposz, Anetta Lasek-Bal, Karina Bartoszek, Patrycja Radecka, Aleksandra Karuga-Pierścieńska
The results of available studies on assessment of neurodegenerative lesions in multiple sclerosis (MS) patients using different approaches have not been conclusive. Currently, clinical assessment is the most commonly used (involving primarily mobility assessment), along with magnetic resonance imaging and electrophysiological testing. In this review we describe available clinical, neuroimaging, electrophysiological and laboratory tests used to assess the neurodegeneration in MS. Laboratory markers to determine the risk of disease, its conversion and prognosis in MS patients are being constantly sought...
November 23, 2017: Neurological Research
https://www.readbyqxmd.com/read/29157166/sub-chronic-boldine-treatment-exerts-anticonvulsant-effects-in-mice
#7
Leila Moezi, Siranoush Yahosseini, Akram Jamshidzadeh, Mona Dastgheib, Fateme Pirsalami
OBJECTIVES: Boldine is an aporphine alkaloid which is best known for its antioxidant, anti-inflammatory and cytoprotective characteristics. It seems that all these activities are related to boldine ability to scavenge reactive free radicals. As indicated by several pieces of evidence, free radicals generation are involved in initiation and propagation of epilepsy. METHODS: In this study, we investigated the sub-chronic effects of boldine on intraperitoneal and intravenous pentylenetetrazole (PTZ) models and electroshock-induced seizure in mice...
November 20, 2017: Neurological Research
https://www.readbyqxmd.com/read/29155646/combination-treatment-of-docosahexaenoic-acid-dha-and-all-trans-retinoic-acid-atra-inhibit-il-17-and-ror%C3%AE-t-gene-expression-in-pbmcs-of-patients-with-relapsing-remitting-multiple-sclerosis
#8
Ateke Mousavi Nasl-Khameneh, Abbas Mirshafiey, Abdorreza Naser Moghadasi, Reza Chahardoli, Maryam Mahmoudi, Karim Parastouei, Mir Saeed Yekaninejad, Ali Akbar Saboor-Yaraghi
OBJECTIVES: Multiple sclerosis (MS) is a demyelinating disorder with a complex autoimmune pathophysiology. Its initiation and progression correlate with IL-17 and the related transcription factor, RORγt. All-trans retinoic acid (ATRA) is a bioactive derivative of vitamin A, and docosahexaenoic acid (DHA) is an active metabolite of omega-3 fatty acid; both have immunomodulatory effects in many immune disorders. This study investigated the effects of DHA and ATRA individually and in combination on IL-17 and RORγt gene expression in peripheral blood mononuclear cells (PBMCs) of relapsing-remitting MS (RRMS) patients who were receiving interferon beta (IFN-β)...
November 18, 2017: Neurological Research
https://www.readbyqxmd.com/read/29126372/exercise-improves-recognition-memory-and-synaptic-plasticity-in-the-prefrontal-cortex-for-rats-modelling-vascular-dementia
#9
Juntao Dong, Jingpu Zhao, Yangyang Lin, Huiying Liang, Xiaokuo He, Xiuyuan Zheng, Minghong Sui, Zhiqiang Zhuang, Tiebin Yan
OBJECTIVES: Functional electrical stimulation (FES) may induce involuntary exercise and make beneficial effects on vascular dementia (VD) by strengthening the BDNF-pCREB-mediated pathway and hippocampal plasticity. Whether FES improves recognition memory and synaptic plasticity in the prefrontal cortex (PFC) was investigated by establishing a VD model. METHODS: The VD rats were administered with two weeks of voluntary exercise, forced exercise, or involuntary exercise induced with FES...
November 10, 2017: Neurological Research
https://www.readbyqxmd.com/read/29125072/predictors-of-dependence-after-mca-ischemic-stroke-submitted-to-thrombolysis
#10
Renata Dal-Prá Ducci, Marcos Christiano Lange, Francisco Manoel Branco Germiniani, Viviane de Hiroki Flumignan Zétola
OBJECTIVES: Stroke is one of the most common causes of disability-adjusted life years worldwide. The aim of this study is to identify variables associated with dependence at 3 months and also after the first 3 months after the first-ever ischemic stroke (IS) in middle cerebral artery (MCA) territory submitted to intravenous thrombolysis (IVT). METHODS: A single-center cohort study of patients with first-ever MCA IS treated with IVT at the Hospital de Clínicas, Universidade Federal do Paraná, was followed over 5 years...
November 10, 2017: Neurological Research
https://www.readbyqxmd.com/read/29125058/edaravone-attenuates-oxidative-stress-induced-by-chronic-cerebral-hypoperfusion-injury-role-of-erk-nrf2-ho-1-signaling-pathway
#11
Dandan Zhang, Yining Xiao, Peiyuan Lv, Zhenjie Teng, Yanhong Dong, Qianqian Qi, Zhijuan Liu
Objectives The potential protective effects and mechanisms of edaravone have not been well elucidated in vascular dementia (VaD) induced by chronic cerebral hypoperfusion (CCH). The aim of this study was to investigate whether edaravone could improve cognitive damage in rats induced by CCH, and whether the effects of edaravone were associated with ERK/Nrf2/HO-1 signaling pathway. Methods CCH was induced by bilateral common carotid arteries occlusion (BCCAO). Sprague-Dawley (SD) rats were randomly divided into four groups: sham (sham-operated) group, vehicle (BCCAO + normal saline) group, edaravone3...
November 10, 2017: Neurological Research
https://www.readbyqxmd.com/read/29105602/a-new-low-profile-visualized-intraluminal-support-lvis-device-lvis-blue-laboratory-comparison-between-old-and-new-lvis
#12
Joonho Chung, Yoshikazu Matsuda, Jessica Nelson, Kiffon Keigher, Demetrius K Lopes
Objectives The Low-profile Visualized Intraluminal Support (LVIS) device is a flexible intracranial stent. The first generation of this system had significant challenges in consistently providing good wall apposition and aneurysm neck coverage. A new modified LVIS, LVIS Blue (Blue), has been developed to address these issues. The purpose of this study is to report a laboratory comparison of wall apposition and aneurysm neck coverage between the original LVIS and Blue. Methods In bench-top experiments, we noted the visual appearance of the devices and evaluated changes in stent cell angles, neck coverage surface area (%), and stent cell crossing profile for microcatheters using a fusiform aneurysm model...
November 5, 2017: Neurological Research
https://www.readbyqxmd.com/read/29105578/role-of-perforin-secretion-from-cd8-t-cells-in-neuronal-cytotoxicity-in-multiple-sclerosis
#13
Daidi Zhao, Fuqiang Feng, Cong Zhao, Fang Wu, Chao Ma, Yanan Bai, Jun Guo, Hongzeng Li
OBJECTIVES: Multiple sclerosis (MS) is the most prevalent autoimmune disease of the central nervous system, and is characterized by inflammation and myelin damage. The immune system initiates the autoimmune response, although the mechanisms of neuronal damage have not been elucidated. The purpose of the present study was to investigate autoreactive CD4+ and CD8(+) T lymphocytes, in conjunction with other inflammatory cells and cytokines in active MS lesions. METHODS: EAE animal models was established by plantar injections of MBP (200 μg per rat)...
November 5, 2017: Neurological Research
https://www.readbyqxmd.com/read/29100486/an-ecv304-monoculture-model-for-permeability-assessment-of-blood-brain-barrier
#14
Shu Yang, Hong Jin, Zhigang Zhao
OBJECTIVE: ECV304/C6 co-culture model is a widely used tool for BBB studies. However, cell source may influence the establishment of co-culture model and some C6 cells could damage the barrier integrity. Here, we established an ECV304 monoculture model and evaluated it in the respect of tightness, tight junction proteins and discriminative brain penetration. METHODS: The tightness of ECV304 cell layers was evaluated by the measurement of permeability to hydrophilic marker Lucifer yellow...
November 3, 2017: Neurological Research
https://www.readbyqxmd.com/read/29088985/anticonvulsant-effect-of-gentamicin-on-the-seizures-induced-by-kainic-acid
#15
Yuxiao Zhao, Ziyi Wang, Wenwen Lao, Ping Kuang, Nan Jiang, Tao Yin, Weide Lin, Hongyan Zhu, Yonghua Ji
OBJECTIVE:  Epilepsy is a chronic neurological disorder affecting approximately 0.5-2% of the population worldwide. Gentamicin (GM) is an aminoglycoside antibiotic used to treat several types of bacterial infections. We investigate whether the administration of GM can reduce seizures in temporal lobe epilepsy (TLE). METHODS: The animal model of temporal lobe epilepsy (TLE) was established by kainic acid (KA) intrahippocampal injection. Behavioral test and Electroencephalography (EEG) recordings were performed to detect the effects of GM on the seizures triggered by KA injection in rats...
October 31, 2017: Neurological Research
https://www.readbyqxmd.com/read/29072550/association-of-glutathione-s-transferases-m1-p1-and-t1-variations-and-risk-of-late-onset-alzheimer-s-disease
#16
Zahra Jafarian, Kioomars Saliminejad, Koorosh Kamali, Mina Ohadi, Ali Kowsari, Leila Nasehi, Hamid Reza Khorram Khorshid
OBJECTIVE: Late-onset Alzheimer's disease (AD) is a genetically heterogeneous neurodegenerative disorder. Associations of the glutathione S-transferases (GSTs) polymorphisms with the risk factors for AD have not been definitely confirmed. We investigated the association of GSTM1 and GSTT1 null deletion and GSTP1 313 A/G polymorphisms and the risk of AD in an Iranian population. METHODS: The case group consisted of 280 individuals with AD and the control group included 168 age-matched healthy individuals...
October 26, 2017: Neurological Research
https://www.readbyqxmd.com/read/29057717/craniovertebral-fixation-%C3%A2-a-new-technique-of-occipital-cervical-fixation
#17
Sushil Patkar
BACKGROUND: Craniovertebral instability following transoral odontoid excision is usually treated by posterior occipital-cervical fixation using occipital plate and cervical lateral mass fixation with screw rod construct. A patient previously operated for basilar invagination had postoperative infection of both the transoral wound and the posterior implant site which needed removal of the posterior implant earlier. CLINICAL PRESENTATION: The patient presented with severe neck pain, myelopathy, and chronic discharging sinus in the posterior lower aspect the previous neck surgery wound...
October 23, 2017: Neurological Research
https://www.readbyqxmd.com/read/29057715/structural-and-functional-alterations-of-the-heart-in-parkinson-s-disease
#18
Jesús Piqueras-Flores, Ana López-García, Álvaro Moreno-Reig, Alicia González-Martínez, Amalia Hernández-González, Julia Vaamonde-Gamo, Alfonso Jurado-Román
Parkinson's disease (PD) patients have most frequently heart failure. The cause of this increased prevalence is not known. We designed a study to assess the cardiac function and cardiac structure in patients with PD compared to a control group. METHODS: Cross-sectional study with 50 PD patients and 50 healthy matched controls. We performed electro and echocardiograms to all patients and controls. The measurements were blind. In addition, we performed a neurological assessment. RESULTS: PD patients had higher left ventricular mass index (114...
October 23, 2017: Neurological Research
https://www.readbyqxmd.com/read/29048255/quality-of-life-in-patients-with-unilateral-vestibular-schwannoma-on-wait-and-see-strategy
#19
P C Klersy, F Arlt, M Hofer, J Meixensberger
OBJECTIVE: A 'wait and see' strategy is an option when managing patients with small vestibular schwannomas (VS). A risk of growth and worsening of hearing may influence a patient's daily quality of life (QOL). Therefore, the present study focused on QOL parameters in patients who are on a 'wait and see' strategy following magnetic resonance imaging (MRI)-based diagnosis of small unilateral VS. PATIENTS AND METHODS: Sixty-five patients (mean age 64.4 years; male:female, 32:33) who suffered from a small unilateral VS (9...
October 19, 2017: Neurological Research
https://www.readbyqxmd.com/read/29262766/neuroanatomical-and-electrophysiological-recovery-in-the-contralateral-intact-cortex-following-transient-focal-cerebral-ischemia-in-rats
#20
Sheng-Yang Huang, Chih-Han Chang, Hsin-Yi Hung, Yu-Wen Lin, E-Jian Lee
Objectives Focal cerebral ischemia may induce synaptic, electrophysiological, and metabolic dysfunction in remote areas. We have shown that the remote dendritic spine density changes and electrophysiological diaschisis in the acute and subacute stages after stroke previously. Here, we further evaluated electrophysiological outcomes and synapto-dendritic plasticity in long-term recovery in the contralateral cortex following focal cerebral ischemia. Methods Male Sprague-Dawley rats were subjected to intraluminal suture occlusion for 90 min or sham-occlusion...
February 2018: Neurological Research
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