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Neurological Research

Qiaofeng Liu, Yanxia Li, Yang Liu, Yanshuang Zhao, Xuemei Li, Yiping Zhang, Chenyi Wang, Wenli Huang, Xin Wang
OBJECTIVE: The objective of this article is to study the role of the dopamine (DA) D1 receptor in the midbrain periaqueductal grey (PAG) on learning and memory in morphine-addicted rats. METHODS: DA D1 receptor agonist SKF81297 and D1 receptor antagonist SCH SCH23390 were administrated into the PAG, respectively, and the learning and memory behavioral changes of morphine addicted rats were detected by water maze. Western blot and immunohistochemistry were used to detect glutamate decarboxylase 67 (GAD67) and tyrosine receptor kinase B (TrkB) in PAG...
September 17, 2018: Neurological Research
Abdul Qayyum Rana, Abdul Rehman M Qureshi, Asna Haris, Muhammad Affan Danish, Muhammad Saad Furqan, Omar Shaikh, Zainab Sarfraz, Ruqqiyah Rana
OBJECTIVE: Pain is an important non-motor symptom of Parkinson's disease (PD); however, it remains understudied. The purpose of previous studies on the relationship between PD and pain, has been to explore the cause, origin and types of pain. This case control study is designed for clinicians and rehabilitation specialists to effectively identify pain from the patient's point of view. Pain present in PD patients correlates with significant disruption to their daily lives, which was seen by analysing characteristics, frequency, severity and interference of pain...
September 15, 2018: Neurological Research
Elisabeth Bründl, Martin Proescholdt, Petra Schödel, Sylvia Bele, Julius Höhne, Florian Zeman, Eva-Maria Stoerr, Alexander Brawanski, Karl-Michael Schebesch
OBJECTIVES: Neuropsychological dysfunction after treatment of spontaneous subarachnoid haemorrhage (sSAH) is common but underreported. The vasoconstrictor neuropeptide Y (NPY) is excessively released after sSAH and in psychiatric disorders. We prospectively analysed the treatment-specific differences in the secretion of endogenous cerebrospinal fluid (CSF) NPY during the acute stage after sSAH and its impact on cognitive processing. METHODS: A total of 26 consecutive patients (f:m = 13:8; mean age 50...
September 14, 2018: Neurological Research
Kenichi Yamada, Yuji Suzuki, Makiko Okuyama, Masaki Watanabe, Tsutomu Nakada
OBJECTIVE: This study aimed to investigate brain developmental alterations in individuals exposed to childhood maltreatment (CM) with dissociative experiences and motor coordination symptoms using diffusion tensor imaging on a 3Tesla (3T) magnetic resonance (MR) system. METHODS: Five individuals exposed to CM who manifest behavioral and developmental problems with dissociative experiences and motor coordination symptoms (age range: 14-18 years; all female), as well as seven age- and gender-matched normal control individuals, participated in the study using a 3T MR system...
September 13, 2018: Neurological Research
Yash Sharma, Nidhi Srivastava, Kumud Bala
OBJECTIVE: Present study was to observe the neuroprotective ability of TMV coat protein by observing both in vitro studies on Rat PC-12 cells and in silico studies with LRRK2 receptor by molecular docking. METHODS: TMV coat protein was extracted out from the stem of Nicotiana tabacum and was purified and identified by MALDI-TOF/MS/MS analysis. We confer antioxidant activity of TMV coat protein by enzyme activity like superoxide dismutase (SOD), catalase (CAT) and glutathione-s-transferase (GST) and nonenzyme content by glutathione (GSH) and malondialdehyde (MDA) content...
September 13, 2018: Neurological Research
O Altintas, E Niftaliyev, T Asil
OBJECTIVES: There is no definitive data regarding the usefulness of Brain microbleeds (BMBs) as an imaging marker with homeostatic markers to predict intracerebral hemorrhage (ICH) and ischemic stroke risk to personalize decisions on anticoagulation in AF. In this study, we prospectively evaluated clinical, radiological homeostatic biomarkers and their association with stroke outcomes in 73 AF-related ischemic stroke patients. METHODS: All BMBs were measured manually on Susceptibility-Weighted Imaging (SWI)...
September 12, 2018: Neurological Research
John K Yue, Ethan A Winkler, Ross C Puffer, Hansen Deng, Ryan R L Phelps, Sagar Wagle, Molly Rose Morrissey, Ernesto J Rivera, Sarah J Runyon, Mary J Vassar, Sabrina R Taylor, Maryse C Cnossen, Hester F Lingsma, Esther L Yuh, Pratik Mukherjee, David M Schnyer, Ava M Puccio, Alex B Valadka, David O Okonkwo, Geoffrey T Manley, The Track-Tbi Investigators
INTRODUCTION: Mild traumatic brain injury (MTBI) can cause persistent functional deficits and healthcare burden. Understanding the association between intracranial contusions and outcome may aid in MTBI treatment and prognosis. METHODS: MTBI patients with Glasgow Coma Scale 13-15 and 6-month outcomes [Glasgow Outcome Scale-Extended (GOSE)], without polytrauma from the prospective TRACK-TBI Pilot study were analyzed. Intracranial contusions on computed tomography (CT) were coded by location...
September 3, 2018: Neurological Research
Takeshi Mikami, Tomoaki Tamada, Hime Suzuki, Ryo Ukai, Masahiko Wanibuchi, Nobuhiro Mikuni
OBJECTIVES: Enlarged perivascular spaces (EPVS) are often observed in small vessel disease on T2-weighted images. However, their role in ischemic conditions caused by cerebral large vessel disease remains unclear. We evaluated EPVS in patients with hemodynamic compromise associated with atherosclerotic large vessel disease and aimed to identify the pathophysiology of EPVS. METHODS: We examined 28 adults with atherosclerotic large vessel disease. EPVS numbers in the basal ganglia and the centrum semiovale were assessed...
August 29, 2018: Neurological Research
Junrong Lei, Qianxue Chen
OBJECTIVE: The aim of this study was to evaluate the potential molecular mechanism of resveratrol (RSV) that attenuates brain damage from focal cerebral ischemia. METHODS AND MATERIALS: To investigate whether phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway was involved in RSV anti-inflammatory and neuroprotective properties. Middle cerebral artery occlusion (MCAO) animal model was used in this study. Adult male Sprague-Dawley (SD) rats underwent MCAO, and then received treatment with RSV or vehicle after the onset of ischemia...
August 29, 2018: Neurological Research
Jagriti Saini, Maitreyee Dutta
OBJECTIVES: An Electroencephalogram (EEG) is the result of co-operative actions performed by brain cells. In other words, it can be defined as the time course of extracellular field potentials that are generated due to the synchronous action of cells. It is widely used for the analysis and diagnosis of several conditions. But this clinical data use to be multi-dimensional, context-dependent, complex, and it causes a concoction of various computing related research challenges. The objective of this study was to develop a computer-aided diagnosis system for epilepsy detection using EEG signals to ease the diagnosis process...
August 29, 2018: Neurological Research
Lanying He, Jian Wang, Ya Liu, Weiwei Dong, Hao Yang, Yong Luo, Tao Xiang, Lun Luo
BACKGROUND AND PURPOSE: Poststroke prognosis is associated with autonomic status. The purpose of our study was to determine whether percutaneous mastoid electrical stimulator (PMES) can alleviate abnormal heart rate variability (HRV) and improve clinical outcome. METHODS: This prospective, randomized, double-blinded, placebo-controlled study enrolled a total of 140 patients with autonomic dysfunction within 3d after acute ischemic stroke. The patients were treated with PMES or sham stimulation once daily over a period of 2 weeks...
August 15, 2018: Neurological Research
Ozlem Ergul Erkec, Sermin Algul, Mehmet Kara
OBJECTIVES: In this study, we aim to reveal the alterations (due to seizure) in the serum and brain levels of nesfatin-1, ghrelin and irisin after acute or chronic pentylenetetrazole administrations in rats using sodium valproate. METHODS: 35 Wistar albino rats were randomly divided into five groups: Control, Acute Pentylenetetrazole group (APTZ), Acute Pentylenetetrazole+ Valproate group (AVPA), PTZ kindling group (PTZk) and PTZ kindling+ Valproate group (KVPA)...
August 15, 2018: Neurological Research
Diana Costa, Camila Cardoso Diogo, Luís Maltez da Costa, José Eduardo Pereira, Vítor Filipe, Pedro Alexandre Couto, Stefano Geuna, Paulo A Armada-Da-Silva, Ana Colette Maurício, Artur S P Varejão
Functional recovery following general nerve reconstruction is often associated with poor results. Comparing to rat and mice experimental studies, there are much fewer investigations on nerve regeneration and repair in the sheep, and there are no studies on this subject using gait analysis in the sheep model as an assessment tool. Additionally, this is the first study evaluating obstacle negotiation and the compensatory strategies that take place at each joint in response to the obstacle during locomotion in the sheep model...
August 14, 2018: Neurological Research
Alexa Alves de Moraes, Cayo Antônio Soares de Almeida, Guilherme Lucas, José Antonio Thomazini, Aline Santos DeMaman
OBJECTIVE: This study aims to investigate morphological alterations caused by partial sciatic nerve ligation (PNL) and the efficacy of a moderate-intensity swimming training as therapeutic strategy for nerve regeneration. METHODS: A number of 30 male adult mice were equally divided in control, 14 days after PNL (PNL 14 days), 42 days after PNL (PNL 42 days), 70 days after PNL (PNL 70 days) and 5-week exercise training after 7 days post-lesion (PNL trained 35 days) groups...
August 9, 2018: Neurological Research
Ramazan Üstün, Elif Kaval Oğuz, Ayşe Şeker, Hasan Korkaya
OBJECTIVE: Peripheral nerve injury (PNI) is a significant health problem that is linked to sensory, motor, and autonomic deficits. This pathological condition leads to a reduced quality of life in most affected individuals. Schwann cells (SCs) play a crucial role in the repair of PNI. Effective agents that promote SC activation may facilitate and accelerate peripheral nerve repair. Thymoquinone (TQ), a bioactive component of Nigella sativa seeds, has an antioxidant, anti-inflammatory, immunomodulatory, and neuroprotective properties...
August 8, 2018: Neurological Research
Hamideh Bashiri, Heshmat Hosseini-Chegeni, Khadijeh Alsadat Sharifi, Mousa Sahebgharani, Ali-Akbar Salari
OBJECTIVE: Memory impairment induced by biliary cirrhosis is associated with abnormalities in the function of different neurotransmitter systems. However, the exact molecular mechanisms involved in the learning and memory dysfunctions following biliary cirrhosis is largely unknown. This study set out to determine whether activation of transient receptor potential vanilloid type 1 (TRPV1) in the CA1 area of the hippocampus in rats improve memory impairment induced by biliary cirrhosis...
August 6, 2018: Neurological Research
Weiji Weng, Xu Chen, Shaohui Gong, Liemei Guo, Xiaohua Zhang
BACKGROUND: Neutrophil-lymphocyte ratio (NLR) is a simple, low-cost and easily measured inflammation marker, corresponding with pathological tumor grading and clinical prognosis in various cancers. OBJECTIVES: This study aimed to investigate the relationship between preoperative NLR and glioma grading and also the correlation between NLR and glioblastoma survival. METHODS: The preoperative NLR was analyzed retrospectively in 239 gliomas of different grades, and receiver operating characteristic (ROC) curve analysis was adopted to investigate the prediction of glioma grading...
August 3, 2018: Neurological Research
Weipeng Zheng, Yimin Chen, Haoyi Chen, Wende Xiao, YingJie Liang, Ning Wang, Xin Jiang, Shifeng Wen
OBJECTIVE: The purpose of this study was to investigate critical genes in multiple sclerosis (MS) using microarray data from brain tissue in MS. MATERIALS: The expression profile data set of MS (GSE38010) downloaded from the Gene Expression Omnibus database contained gene information from five plaque tissues from MS brains and two white matter tissues from healthy controls. An R package was applied to process these raw chip data. Gene Ontology (GO) functional analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and protein-protein interaction (PPI) network analysis were performed to investigate interactions between differentially expressed genes (DEGs) in MS brain tissues...
August 3, 2018: Neurological Research
Zhiheng Sun, Yi Lin, Ying Li, Tong Ren, Guicheng Du, Jia Wang, Xin Jin, Li-Chao Yang
OBJECTIVE: Microglia have different phenotypic and functional states: M1 is associated with inflammatory responses, whereas M2 results in anti-inflammatory effects. The cellular state of microglia plays an important role in brain inflammation associating with many neuroinflammatory diseases. The purpose of this study was to detect the effect of dexmedetomidine (Dex) on inflammatory inhibition and microglial polarization in BV-2 cells. MATERIALS AND METHODS: Dex exerts anti-inflammatory effects in various experimental models...
August 2, 2018: Neurological Research
Lei Chen, Shanshan Cao, Junxiu Yang
OBJECTIVES: Anticoagulant therapy in the acute phase of AIS remains controversial. The aim of this study was to investigate whether argatroban benefited early stroke outcomes compared with antiplatelet treatment. METHODS: We reviewed data from 1,485 patients with AIS hospitalized at Tianjin Union Medical Center (TUMC) between 1 January 2013 and 31 December 2015 from the TUMC registry database. Patients were divided into two groups: an antiplatelet group (aspirin 300 mg daily) and an argatroban group (argatroban 60 mg for 2 days followed by 20 mg daily; or 20 mg daily - both regimens combination with aspirin 100 mg daily)...
July 27, 2018: Neurological Research
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