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Neurological Research

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https://www.readbyqxmd.com/read/28604272/the-use-of-sheep-as-a-model-for-studying-peripheral-nerve-regeneration-following-nerve-injury-review-of-the-literature
#1
Camila Cardoso Diogo, José Arthur Camassa, José Eduardo Pereira, Luís Maltez da Costa, Vítor Filipe, Pedro Alexandre Couto, Stefano Geuna, Ana Colette Maurício, Artur Severo Varejão
Peripheral nerve injury and regeneration is a challenging scientific field with relevant clinical implications. Most peripheral nerve regeneration studies have been mainly carried out on rodents. However, it is important to note that the validity of the rodent as a model to study nerve injury and regeneration and translate these results into clinical practice has been questioned by several researchers. To overcome this problem, some investigators have used companion animals and large animal species as models for experimental peripheral nerve regeneration studies...
June 11, 2017: Neurological Research
https://www.readbyqxmd.com/read/28592211/calmodulin-like-skin-protein-is-downregulated-in-human-cerebrospinal-fluids-of-alzheimer-s-disease-patients-with-apolipoprotein-e4-a-pilot-study-using-postmortem-samples
#2
Yuichi Hashimoto, Takahiko Umahara, Haruo Hanyu, Toshihiko Iwamoto, Masaaki Matsuoka
OBJECTIVE: Calmodulin-like skin protein (CLSP) is a secreted peptide that inhibits neuronal cell death, linked to Alzheimer's disease (AD), by binding to the heterotrimeric humanin receptor and activating an intracellular survival pathway. CLSP is only expressed in skin keratinocytes and related epithelial cells, circulates in the blood stream, and passes the blood-cerebrospinal fluid (CSF) barrier. In the current study, we addressed the issues as to whether CLSP functions in the central nervous system and whether the concentration of CLSP is reduced in the CSFs of AD patients...
June 7, 2017: Neurological Research
https://www.readbyqxmd.com/read/28566060/topical-application-of-the-hematostatic-agent-surgiflo%C3%A2-could-attenuate-brain-injury-in-experimental-tbi-mice
#3
Dewei Guo, Dongpeng Li, Jinghong Li, Yunfeng Li, Xiang Hu, Fangxia Guan, Bo Yang
OBJECT: The pathologies resulting from traumatic brain injury (TBI) have been thoroughly studied, but rarely have the effects of bleeding and coagulation in the early stage of TBI been considered. In this study, we investigated the effects of topical Surgiflo(®) application on brain injury in experimental TBI mice using S100β, MAP-2 and mNSS scores. METHODS: TBI was induced by modified weight drop injury in male C57BL/6 mice. The mice were then randomly divided into (i) the sham group, (ii) TBI mice applied with saline (vehicle), and (iii) TBI mice applied with Surgiflo(®) in the same volume...
May 31, 2017: Neurological Research
https://www.readbyqxmd.com/read/28562233/relationship-of-phosphodiesterase-4d-pde4d-gene-polymorphisms-with-risk-of-ischemic-stroke-a-hospital-based-case-control-study
#4
Amit Kumar, Shubham Misra, Pradeep Kumar, Ram Sagar, Arti Gulati, Kameshwar Prasad
BACKGROUND: Stroke remains a leading cause of death and disability worldwide. Ischemic stroke (IS) accounts for around 80-85% of total stroke and is a complex polygenic multi-factorial disorder which is affected by a complex combination of vascular, environmental, and genetic factors. OBJECTIVE: The study was conducted with an aim to examine the relationship of single nucleotide polymorphisms (SNPs) of PDE4D (T83C, C87T, and C45T) gene with increasing risk of IS in patients in North Indian population...
May 31, 2017: Neurological Research
https://www.readbyqxmd.com/read/28552032/the-role-of-microrna-in-neuronal-inflammation-and-survival-in-the-post-ischemic-brain-a-review
#5
William A Li, Aslan Efendizade, Yuchuan Ding
Each year, more than 790 000 people in the United States suffer from a stroke. Although progress has been made in diagnosis and treatment of ischemic stroke (IS), new therapeutic interventions to protect the brain during an ischemic insult is highly needed. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression post-transcriptionally. Growing evidence suggests that miRNAs have a profound impact on ischemic stroke progression and are potential targets of novel treatments. Notably, inflammatory pathways play an important role in the pathogenesis of ischemic stroke and its pathophysiologic progression...
May 27, 2017: Neurological Research
https://www.readbyqxmd.com/read/28531358/vitamin-b1-deficiency-in-patients-with-postural-tachycardia-syndrome-pots
#6
Svetlana Blitshteyn
OBJECTIVE: POTS is a heterogeneous disorder of the autonomic nervous system that can result from multiple etiologies. An increased prevalence of vitamin B12, vitamin D 25-OH and iron deficiencies has been observed in patients with POTS. This study examined the prevalence of vitamin B1 deficiency and assessed response to vitamin B1 supplementation in the deficient POTS patients. METHODS AND RESULTS: Medical records of 65 consecutive patients with POTS evaluated at our clinic were reviewed...
May 21, 2017: Neurological Research
https://www.readbyqxmd.com/read/28502217/hippocampal-low-frequency-stimulation-inhibits-afterdischarge-and-increases-gaba-a-receptor-expression-in-amygdala-kindled-pharmacoresistant-epileptic-rats
#7
Guofeng Wu, Likun Wang, Zhen Hong, Siying Ren, Feng Zhou
OBJECTIVE: The purpose of the present study was to observe the effects of hippocampal low-frequency stimulation (Hip-LFS) on amygdala afterdischarge and GABA (A) receptor expression in pharmacoresistant epileptic (PRE) rats. METHODS: A total of 110 healthy adult male Wistar rats were used to generate a model of epilepsy by chronic stimulation of the amygdala. Sixteen PRE rats were selected from 70 amygdala-kindled rats by testing their response to Phenytoin and Phenobarbital, and they were randomly assigned to a pharmacoresistant stimulation group (PRS group, 8 rats) or a pharmacoresistant control group (PRC group, 8 rats)...
May 14, 2017: Neurological Research
https://www.readbyqxmd.com/read/28502216/a-retrospective-analysis-of-postoperative-recurrence-of-septated-chronic-subdural-haematoma-endoscopic-surgery-versus-burr-hole-craniotomy
#8
Kaixuan Yan, Heng Gao, Xinmin Zhou, Wei Wu, Weidong Xu, Yu Xu, Kai Gong, Xinchen Xue, Qipin Wang, Hanrong Na
OBJECTIVE: To identify the factors associated with Septated chronic subdural haematoma (sCSDH) recurrence and to compare the advantages and disadvantages of burr hole craniotomy (BHC) and endoscopic surgery (ES) with respect to preventing sCSDH recurrence. METHODS: A total of 76 consecutive patients with sCSDH underwent BHC or ES in our institution. Their clinical data were retrospectively analysed to identify the factors associated with sCSDH recurrence and to evaluate the effectiveness of BHC and ES with respect to preventing sCSDH recurrence...
May 13, 2017: Neurological Research
https://www.readbyqxmd.com/read/28490273/corrigendum
#9
(no author information available yet)
No abstract text is available yet for this article.
May 11, 2017: Neurological Research
https://www.readbyqxmd.com/read/28481152/aspirin-attenuates-spontaneous-recurrent-seizures-in-the-chronically-epileptic-mice
#10
Kun Zhu, Ming Hu, Bo Yuan, Jian-Xin Liu, Yong Liu
OBJECTIVE: Neuroinflammatory processes are pathologic hallmarks of both experimental and human epilepsy, and could be implicated in the neuronal hyperexcitability. Aspirin represents one of the non-selective nonsteroidal anti-inflammatory drugs with fewer side effects in long-term application. This study was carried out to assess the anti-epileptic effects of aspirin when administered during the chronic stage of temporal lobe epilepsy [TLE] in mice. The alteration of hippocampal neurogenesis was also examined for raising a possible mechanism underlying the protective effect of anti-inflammatory treatment in the TLE...
May 7, 2017: Neurological Research
https://www.readbyqxmd.com/read/28475469/higher-ambulatory-systolic-blood-pressure-independently-associated-with-enlarged-perivascular-spaces-in-basal-ganglia
#11
Shuna Yang, Junliang Yuan, Xiaoyu Zhang, Huimin Fan, Yue Li, Jiangmei Yin, Wenli Hu
BACKGROUNDS: Enlarged perivascular spaces (EPVS) have been identified as a marker of cerebral small vessel diseases (CSVD). Ambulatory blood pressure (ABP) is the strongest predictor of hypertension-related brain damage. However, the relationship between ABP levels and EPVS is unclear. OBJECTIVES: This study aimed to investigate the association between ABP levels and EPVS by 24-hour ambulatory blood pressure monitoring (ABPM). METHODS: We prospectively recruited inpatients for physical examinations in our hospital from May 2013 to Jun 2016...
May 5, 2017: Neurological Research
https://www.readbyqxmd.com/read/28468601/anticonvulsant-activity-of-caryocar-coriaceum-wittm-fixed-pulp-oil-against-pentylenetetrazol-induced-seizures
#12
Cleide Correia Oliveira, Clarissa Vasconcelos Oliveira, Jéssica Grigoletto, Leandro Rodrigo Ribeiro, Vinícius Rafael Funck, Letícia Meier, Michele Rechia Fighera, Luiz Fernando Freire Royes, Ana Flávia Furian, Irwin Rose Alencar Menezes, Mauro Schneider Oliveira
OBJECTIVES: Epilepsy is a common brain disease and a major worldwide public health problem. The seizures in a significant number of patients suffering from epilepsy remain inadequately controlled by currently available pharmacological treatments. Accordingly, there is a need for the discovery of new anticonvulsant approaches with improved efficacy and a better safety profile. In this context, natural products can be a valuable source of substances with potential anticonvulsant activity...
May 3, 2017: Neurological Research
https://www.readbyqxmd.com/read/28460604/the-15-lo-1-15-hete-system-promotes-angiogenesis-by-upregulating-vegf-in-ischemic-brains
#13
Li Chen, Yan-Mei Zhu, Yu-Nong Li, Peng-Yan Li, Di Wang, Yu Liu, You-Yang Qu, Da-Ling Zhu, Yu-Lan Zhu
OBJECTIVES: Angiogenesis promotes neurobehavioral recovery after cerebral ischemic stroke. 15(S)-hydroxyeicosatetraenoic acid (15-HETE) is one of the major metabolites of arachidonic acid by 15-lipoxygenase (15-LO) and stimulates the production of vascular endothelial growth factor (VEGF), thus, inducing autocrine-mediated angiogenesis. The present study aimed to investigate the role of 15-LO/15-HETE system on VEGF expression and angiogenesis in brain ischemia. METHODS: Rat cerebral arterial vascular endothelial cells were used to set up a cell injury model of oxygen-glucose deprivation and reoxygenation (OGD/R), mimicking a condition of brain ischemia...
May 1, 2017: Neurological Research
https://www.readbyqxmd.com/read/28460598/circulating-igf-1-igfb-3-gh-and-tsh-levels-in-multiple-sclerosis-and-their-relationship-with-treatment
#14
Aylin Akcali, Berrin Bal, Binnur Erbagci
OBJECTIVES: Improving the proficiency of oligodendrocytes in their ability to repair myelin damage is one of the major goals of multiple sclerosis treatment. Insulin-like growth factor-1 (IGF-1) is one of several polypeptides that are considered to have potential benefits in that sense. In the present study, we aimed to determine serum levels of IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3), thyroid stimulating hormone (TSH) and growth hormone (GH) among treated and non-treated patients with Relapsing-Remitting Multiple Sclerosis (RRMS) and a healthy control group...
May 1, 2017: Neurological Research
https://www.readbyqxmd.com/read/28460569/neurological-outcome-and-frequency-of-overdrainage-in-normal-pressure-hydrocephalus-directly-correlates-with-implanted-ventriculo-peritoneal-shunt-valve-type
#15
Yavor Bozhkov, Karl Roessler, Nirjhar Hore, Michael Buchfelder, Sebastian Brandner
BACKGROUND: The correlation between neurological outcome and frequency of overdrainage in the management of idiopathic normal pressure hydrocephalus (iNPH) using different ventriculoperitoneal shunt valve types is under investigation. Thus, we retrospectively compared one group of iNPH patients implanted with a programmable differential pressure valve (DPV) with another group treated by implantation of a DPV in combination with a flow-regulated anti-siphon device valve (ASD). METHODS: A retrospective evaluation of clinical outcome and frequency of overdrainage of 40 consecutive iNPH patients following surgical management between 08/2010 and 08/2014 was performed...
May 1, 2017: Neurological Research
https://www.readbyqxmd.com/read/28436304/the-pten-inhibitor-bpv-pic-promotes-neuroprotection-against-amyloid-%C3%AE-peptide-25-35-induced-oxidative-stress-and-neurotoxicity
#16
Xiao-Ying Liu, Li-Jing Zhang, Zhou Chen, Li-Bin Liu
OBJECTIVES: The aim of this study was to elucidate the mechanism underlying the neuroprotective effects of the phosphatase and tensin homolog (PTEN) inhibitor, bisperoxovanadium-pic [bpV(pic)]. METHODS: We determined the effects of bpV(pic) on amyloid-β-peptide-(25-35)-induced neurotoxicity, particularly intracellular reactive oxygen species (ROS) production and mitochondria-mediated apoptotic signaling, in a human neuroblastoma (SH-SY5Y) cell model. RESULTS: We found that exposure of SH-SY5Y cells to amyloid β peptides (Aβ25-35) resulted in a significant reduction in cell viability accompanied by increased lactate dehydrogenase (LDH) release, elevated levels of intracellular ROS, and decreased superoxide dismutase (SOD) activities, all of which were reversed by co-treatment with bpV(pic)...
April 23, 2017: Neurological Research
https://www.readbyqxmd.com/read/28415958/glycyrrhizic-acid-exerts-anti-inflammatory-effect-to-improve-cerebral-vasospasm-secondary-to-subarachnoid-hemorrhage-in-a-rat-model
#17
Yi Li, Fengbin Sun, Zhaohui Jing, Xuhui Wang, Xuming Hua, Liang Wan
This study aimed to investigate the therapeutic effect of glycyrrhizic acid (GA) on the cerebral vasospasm (CVS) in a rat subarachnoid hemorrhage (SAH) model and to explore the potential mechanism. A total of 44 healthy male rats were randomly assigned into 3 groups: control group (n = 12), SAH group (n = 16) and GA group (n = 16). No treatment was conducted in control group; in SAH group and GA group, experimental CVS was induced using a double-hemorrhage model and then rats were intraperitoneally injected with normal saline and GA at 10 mg/kg, respectively, once daily...
April 17, 2017: Neurological Research
https://www.readbyqxmd.com/read/28403693/anterior-retropharyngeal-plate-screw-fixation-with-bilateral-anterior-transarticular-screws-for-odontoid-fractures-a-new-comprehensive-technique
#18
Sushil Patkar
INTRODUCTION: A certain group of odontoid fractures (Anderson and D' Alonzo Type-2) are usually offered surgical treatment. Common surgical option is an anterior odontoid screw. Some of the fractures are not suitable for anterior odontoid screw (anterior oblique, displaced distal fragments and those with atlantoaxial instability) and these are usually offered posterior transarticular screws (Magerl's) or posterior atlantoaxial screw rod/plate fixation (Goel-Harms technique). Posterior surgery involves atlantoaxial fixation with an indirect attempt to reduce and fuse the fracture ...
April 13, 2017: Neurological Research
https://www.readbyqxmd.com/read/28403681/atrophy-ultra-structural-disorders-severe-atrophy-and-degeneration-of-denervated-human-muscle-in-sci-and-aging-implications-for-their-recovery-by-functional-electrical-stimulation-updated-2017
#19
Helmut Kern, Cristian Hofer, Stefan Loefler, Sandra Zampieri, Paolo Gargiulo, Alfonc Baba, Andrea Marcante, Francesco Piccione, Amber Pond, Ugo Carraro
OBJECTIVES: Long-term lower motor neuron denervation of skeletal muscle is known to result in degeneration of muscle with replacement by adipose and fibrotic tissues. However, long-term survival of a subset of skeletal myofibers also occurs. METHODS: We performed transverse and longitudinal studies of patients with spinal cord injury (SCI), patients specifically complete Conus and Cauda Equina Syndrome and also of active and sedentary seniors which included analyses of muscle biopsies from the quadriceps m...
April 13, 2017: Neurological Research
https://www.readbyqxmd.com/read/28403684/mangiferin-prevents-corticosterone-induced-behavioural-deficits-via-alleviation-of-oxido-nitrosative-stress-and-down-regulation-of-indoleamine-2-3-dioxygenase-ido-activity
#20
Gao-Quan Luo, Ling Liu, Qu-Wen Gao, Xiao-Na Wu, Wei Xiang, Wen-Ting Deng
BACKGROUND: In recent years, a substantial amount of experimental studies have demonstrated that exogenous administration of corticosterone causes anxiety and depressive-like behaviour in rodents which involves hypothalamic-pituitary-adrenal axis dysregulation. Our present study aimed to explore the neuroprotective potential of mangiferin against corticosterone-induced anxiety and depressive-like behaviour. METHODS: Corticosterone (40 mg/kg; subcutaneously) was administered once daily in swiss albino mice for 21 days...
April 12, 2017: Neurological Research
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