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Nutrition and Cancer

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https://www.readbyqxmd.com/read/29781726/in-vitro-analysis-of-glucose-and-quercetin-effects-on-m-tor-and-nrf-2-expression-in-hepg2-cell-line-diabetes-and-cancer-connection
#1
Amir Yarahmadi, Fatemeh Khademi, Zohreh Mostafavi-Pour, Fatemeh Zal
Some types of cancers show a strong relationship with diabetes and play a central role in mortality in the patient population suffering from diabetes mellitus. In this study, HepG2 cells have been used to investigate the toxic effects of hyperglycemia and/or quercetin (Q) on mammalian target of rapamycin (m-TOR) and nuclear factor erythroid 2-related factor 2 (Nrf-2) expression as central molecules involved in cancer. HepG2 cells were cultured with different concentrations of glucose (5.5, 30, and 50 mM) and/or Q (25 µM) for 48 and 72 h...
May 21, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29781720/supplementation-of-vitamin-d-deficiency-in-patients-with-neuroendocrine-tumors-using-over-the-counter-vitamin-d3-preparations
#2
Helen L Robbins, Megan Symington, Barbara Mosterman, Josie Goodby, Louise Davies, Georgios K Dimitriadis, Gregory Kaltsas, Harpal S Randeva, Martin O Weickert
Vitamin D (vit-D) deficiency is highly prevalent in patients with gastro-entero-pancreatic neuroendocrine tumors (GEP-NET) and has been linked to reduced overall survival. We here assessed the vit-D status in 183 patients with GEP-NET at the time of their first presentation in the ARDEN NET Centre. We further examined the effect of simple advice to increase vit-D intake using over-the-counter vit-D preparations [colecalciferol (Vit-D3), 1,000-2,000 units/day], over a prospective observation period of 24 mo...
May 21, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29781715/andrographolide-exhibits-anticancer-potential-against-human-colon-cancer-cells-by-inducing-cell-cycle-arrest-and-programmed-cell-death-via-augmentation-of-intracellular-reactive-oxygen-species-level
#3
Imran Khan, Fahad Khan, Arshi Farooqui, Irfan A Ansari
Andrographolide, a diterpenoid lactone and a major constituent of Andrographis paniculata Nees, exhibits remarkable anticancer activity. However, the effect of andrographolide on colon cancer has not been completely elucidated yet. Thus, we investigated the chemopreventive potential of andrographolide in colon cancer HT-29 cells. The cytotoxic potential of andrographolide on HT-29 cells was determined by MTT assay, trypan blue exclusion assay, colony formation assay, and morphological analysis; and apoptotic property by DAPI and Hoechst staining, FITC-Annexin V assay, DNA fragmentation assay and caspase-3 activity assay...
May 21, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29781707/associations-of-whole-and-refined-grain-intakes-with-adiposity-related-cancer-risk-in-the-framingham-offspring-cohort-1991-2013
#4
Nour Makarem, Elisa V Bandera, Yong Lin, Nicola M McKeown, Richard B Hayes, Niyati Parekh
Case-control studies suggest that higher whole grain and lower refined grain intakes are associated with reduced cancer risk, but longitudinal evidence is limited. The objective of this prospective cohort study is to evaluate associations between whole and refined grains and their food sources in relation to adiposity-related cancer risk. Participants were adults from the Framingham Offspring cohort (N = 3,184; ≥18 yr). Diet, measured using a food frequency questionnaire, medical and lifestyle data were collected at exam 5 (1991-95)...
May 21, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29764209/next-gen-therapeutics-for-skin-cancer-nutraceuticals
#5
Annapoorna Sreedhar, Jun Li, Yunfeng Zhao
Growing modernization and lifestyle changes with limited physical activity have impacted diet and health, leading to an increased cancer mortality rate worldwide. As a result, there is a greater need than before to develop safe and novel anticancer drugs. Current treatment options such as chemotherapy, radiotherapy and surgery, induce unintended side effects, compromising patient's quality of life, and physical well-being. Therefore, there has been an increased global interest in the use of dietary supplements and traditional herbal medicines for treatment of cancer...
May 15, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29757003/transglutaminase-2-mediates-the-cytotoxicity-of-resveratrol-in-a-human-cholangiocarcinoma-and-gallbladder-cancer-cell-lines
#6
Leda Roncoroni, Luca Elli, Paola Braidotti, Delfina Tosi, Valentina Vaira, Lorenza Tacchini, Vincenza Lombardo, Federica Branchi, Alice Scricciolo, Luisa Doneda
Resveratrol is a polyphenolic compound extracted from plants and is also a constituent of red wine. Our aim was to evaluate if the cytotoxic effect of resveratrol (RES) on cholangiocarcinoma (CC) and gallbladder cancer (GBC) cell lines could be abolished by TG2 inhibition. Human CC and GBC cell lines (SK-ChA-1 and MZ-ChA-1), grown in a three-dimensional cell culture system (MCTS, multicellular tumor spheroids), were treated for 72 h with RES (32, 64 µM) alone or combined with different TG2 inhibitors (Cystamine, B003, T101)...
May 14, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29746191/future-research-directions-for-the-trophoblast-model-of-cancer
#7
Colin A Ross
The trophoblast model of cancer is incorporated into The Gonzalez Protocol for treatment of cancer and a range of noncancer chronic diseases. The other main component of the Protocol involves the prescription of detailed diets and supplementation. The foundation of the diet and supplementation component of the Protocol is the theory of autonomic types, which range from parasympathetic-dominant, through balanced, to sympathetic-dominant; a person's autonomic type determines the details of the prescribed diet and supplements...
May 10, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29781734/dairy-consumption-and-risk-of-testicular-cancer-a-systematic-review
#8
Virginia Signal, Stephanie Huang, Diana Sarfati, James Stanley, Katherine A McGlynn, Jason K Gurney
Dairy consumption has been studied extensively in terms of its relationship with testicular cancer (TC), yet this relationship remains unclear. In this systematic review, we aimed to answer whether TC development is associated with (a) high amounts of dairy product consumption, (b) the type of dairy product consumed, (c) increasing levels of dairy product consumption, and (d) dairy consumption during certain periods during the lifecourse. Following a systematic review of the literature, eight studies (all case-control studies) were included in our review...
July 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29781719/serum-vitamin-d-status-and-breast-cancer-risk-by-receptor-status-a-systematic-review
#9
Jessica L Tommie, Susan M Pinney, Laurie A Nommsen-Rivers
BACKGROUND: The association between vitamin D status and breast cancer risk is equivocal. No systematic reviews or meta-analyses have examined this association stratified by receptor status. Our objective is to conduct a systematic review to answer the question, "Is there a relationship between lower serum/plasma vitamin D levels and increased risk of triple negative breast cancer (TNBC) specifically?" METHODS: We systematically searched Embase and PubMed databases for published original research studies examining the risk of a breast cancer diagnosis according to vitamin D status...
July 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29708445/latest-in-vitro-and-in-vivo-assay-clinical-trials-and-patents-in-cancer-treatment-using-curcumin-a-literature-review
#10
Kevin Doello, Raúl Ortiz, Pablo J Alvarez, Consolación Melguizo, Laura Cabeza, José Prados
Curcumin, the main active compound of the curcuma root, shows antioxidant, anti-inflammatory, and antitumor properties which have been demonstrated in preclinical and clinical trials. Its antitumor activity is mediated by its ability to act directly on the tumor cell, activating apoptosis pathways and indirectly inhibiting the process of inflammation, angiogenesis, and metastasis in the tumor microenvironment. In addition, it has a preventive activity such as radio and/or chemosensitizer. These effects have been evident in in vitro assays but have also been corroborated in patient trials either through the isolated use of curcumin or through its association with other agents...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29708405/coffee-drinking-and-the-risk-of-endometrial-cancer-an-updated-meta-analysis-of-observational-studies
#11
Marko Lukic, Neela Guha, Idlir Licaj, Piet A van den Brandt, Leslie Thomas Stayner, Alessandra Tavani, Elisabete Weiderpass
BACKGROUND: Several compounds contained in coffee have been found to suppress carcinogenesis in experimental studies. We conducted a dose-response meta-analysis to assess the impact of coffee consumption on the risk of endometrial cancer. MATERIALS AND METHODS: We searched MEDLINE and EMBASE databases for studies published up to August 2016. Using random effects models, we estimated summary relative risks (RR) for cohort studies and odds ratios (OR) for case-control studies with 95% confidence intervals (CI)...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29697284/biological-and-immunological-aspects-of-iron-deficiency-anemia-in-cancer-development-a-narrative-review
#12
Fatema Zohora, Katayoon Bidad, Zahra Pourpak, Mostafa Moin
Iron Deficiency Anemia (IDA) is a universal health problem and a risk factor for the development of cancer. IDA changes the microenvironment of the human body by affecting both the biological and immunological systems. It increases DNA damage and genomic instability by different mechanisms. IDA is one of the leading causes of the imbalance between different antioxidant enzymes as well as enzymes involved in DNA damage and DNA repair systems of the body. It can affect the biogenesis/expression of microRNAs. IDA interrupts the oxidative phosphorylation energy metabolism and intestinal Cytochrome-P450 systems...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29697283/antitumoral-potency-by-immunomodulation-of-chloroform-extract-from-leaves-of-nitraria-retusa-tunisian-medicinal-plant-via-its-major-compounds-%C3%AE-sitosterol-and-palmitic-acid-in-balb-c-mice-bearing-induced-tumor
#13
Jihed Boubaker, Imene Ben Toumia, Aicha Sassi, Imen Bzouich-Mokded, Sonia Ghoul Mazgar, Fairouz Sioud, Ahmed Bedoui, Sihem Safta Skhiri, Kamel Ghedira, Leila Chekir-Ghedira
This study evaluated the antitumoral effect of Chloroform extract from Nitraria retusa leaves, via its major compounds β-sitosterols and palmitic acid. BALB/c mice were subcutaneously inoculated with B16-F10 cells, then treated intra-peritoneally after 7 days with the chloroform extract for 21 days. They were then euthanized, and the tumors were weighed. Lung parenchyma was analyzed. Lymphocyte and macrophages proliferation, cytotoxic T lymphocyte (CTL) activities were evaluated using the MTT assay. Macrophage phagocytosis was evaluated by measuring the lysosomal activity and nitric oxide production...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29697282/the-role-of-genetic-variants-in-the-association-between-dietary-acrylamide-and-advanced-prostate-cancer-in-the-netherlands-cohort-study-on-diet-and-cancer
#14
Andy Perloy, Leo J Schouten, Piet A van den Brandt, Roger Godschalk, Frederik-Jan van Schooten, Janneke G F Hogervorst
To investigate the association between dietary acrylanide and advanced prostate cancer, we examined acrylamide-gene interactions for advanced prostate cancer risk by using data from the Netherlands Cohort Study. Participants (n = 58,279 men) completed a baseline food frequency questionnaire (FFQ), from which daily acrylamide intake was calculated. At baseline, 2,411 men were randomly selected from the full cohort for case-cohort analysis. Fifty eight selected single nucleotide polymorphisms (SNPs) and two gene deletions in genes in acrylamide metabolism, DNA repair, sex steroid systems, and oxidative stress were analyzed...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29697280/effect-of-saccharomyces-boulardii-cell-wall-extracts-on-colon-cancer-prevention-in-male-f344-rats-treated-with-1-2-dimethylhydrazine
#15
Olivier Fortin, Blanca R Aguilar-Uscanga, Khanh D Vu, Stephane Salmieri, Monique Lacroix
The effect of Saccharomyces boulardii cell wall extracts on colon cancer prevention in rats treated with 1,2-dimethylhydrazine was investigated. A crude insoluble glucan (0.5 and 1.0 mg/kg/day) and a crude mannoprotein extract (0.3 and 3.0 mg/kg/day) were administered in rats by gavage for 12 weeks along with a high fat low fiber diet whereupon rats were sacrificed and aberrant crypt foci (ACF) were counted in the colon. Moreover, NAD(P)H: quinone reductase (QR) and harmful fecal enzymes (β-glucosidase and β-glucuronidase) were quantified in the liver and in the caecum, respectively...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29697274/effect-of-eicosapentaenoic-acid-on-body-composition-and-inflammation-markers-in-patients-with-head-and-neck-squamous-cell-cancer-from-a-public-hospital-in-mexico
#16
Obed Solís-Martínez, Valentina Plasa-Carvalho, Geraldine Phillips-Sixtos, Yanelly Trujillo-Cabrera, Arturo Hernández-Cuellar, Gloria E Queipo-García, Eduardo Meaney-Mendiolea, Guillermo M Ceballos-Reyes, Vanessa Fuchs-Tarlovsky
INTRODUCTION: Head and neck cancer patients are at high risk of anorexia-cachexia syndrome and literature shows that Eicosapentaenoic acid (EPA) could regulate it. We aim to determine the EPA effect on body composition and pro-inflammatory markers in patients with head neck cancer. MATERIALS AND METHODS: A randomized single-blind placebo-controlled clinical trial was conducted in patients with head and neck squamous cell cancer who received a polymeric diet with 2 g of EPA or a standard polymeric diet for six weeks before antineoplastic treatment...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29697270/antitumor-properties-of-cla-enriched-food-products
#17
Aneta A Koronowicz, Paula Banks
In this manuscript, we reviewed the available literature on the effects of conjugated linoleic acid (CLA)-enriched food products, including meat, dairy products, and eggs on cancer, both in vivo and in vitro. Based on our own studies on CLA-enriched eggs, we also identified potential molecular mechanisms by which such products may act on cancer cells. We propose the mitochondrial apoptosis pathway as mainly accountable for the reduction of cancer cells viability. Our hypothesis is supported by observed changes in expression of genes associated with downregulation of AKT/mTOR signalling pathway...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29697268/l-ascorbic-acid-and-%C3%AE-tocopherol-reduces-hepatotoxicity-associated-with-arsenic-trioxide-chemotherapy-by-modulating-nrf2-and-bcl2-transcription-factors-in-chang-liver-cells
#18
Radhakrishnan Chandraprabha Vineetha, Viswanathan Archana, Prakash Binu, Pettamanna Arathi, Raveendran Harikumaran Nair
Arsenic trioxide (As2 O3 ) is a promising new regimen for the treatment of acute promyelocytic leukemia (APL). The induction of oxidative stress mediated by reactive oxygen species (ROS) and excessive intracellular calcium influx are the main reasons behind As2 O3 toxicity. Since liver is the major organ for xenobiotic metabolism, it is always under stress. Antioxidant vitamins such as L-Ascorbic acid (L-AA) and α-Tocopherol (α-TOC) have been proposed to have beneficial effects against a variety of pathological conditions and are known by their free radical scavenging properties...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29693446/selective-cytotoxicity-of-luteolin-and-kaempferol-on-cancerous-hepatocytes-obtained-from-rat-model-of-hepatocellular-carcinoma-involvement-of-ros-mediated-mitochondrial-targeting
#19
Enayatollah Seydi, Ahmad Salimi, Hamid Reza Rasekh, Zhaleh Mohsenifar, Jalal Pourahmad
To evaluate the cytotoxicity effects of luteolin (LUT) and kaempferol (KAE) via reactive oxygen species (ROS) mediated mitochondrial targeting on hepatocytes obtained from the liver of hepatocellular carcinoma (HCC) rats. In this study, HCC induced by diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF). In the following, rat liver hepatocytes and mitochondria were isolated and tested for every eventual apoptotic and anti-HCC effects of LUT and KAE. The results of MTT assay showed that LUT and KAE were able to induce selective cytotoxicity in hepatocytes of HCC group in a dose- and time-dependent manner...
May 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29693426/usual-cruciferous-vegetable-consumption-and-ovarian-cancer-a-case-control-study
#20
Hallie McManus, Kirsten B Moysich, Li Tang, Janine Joseph, Susan E McCann
Ovarian cancer is the fifth leading cause of cancer-related deaths among women, primarily due to diagnosis at late stages. Therefore, identification of modifiable risk factors for this disease is warranted. Using the Patient Epidemiology Data System (PEDS), collected from 1981 to 1998 at Roswell Park Cancer Institute, Buffalo, NY, we conducted a hospital-based, case-control analysis of self-reported cruciferous vegetable intake and ovarian cancer among 675 women with primary, incident ovarian cancer, and 1275 without cancer...
May 2018: Nutrition and Cancer
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