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Nutrition and Cancer

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https://www.readbyqxmd.com/read/29043851/antioxidants-in-the-treatment-of-cancer
#1
Kanthi Athreya, Marin F Xavier
Several clinical trials have produced conflicting results regarding the benefit of antioxidants in cancer therapy thus questioning the incorporation of these substances in standard treatment regimens. Vitamins E and C, selenium, carotenoids, lycopene, soy products, and green tea extract are a few substances with antioxidant properties that have been studied in detail. This article reviews the results generated over the last 20 years through in vitro and in vivo studies in various types of cancers and stages of cancer treatment...
October 18, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29043842/the-protective-and-immunomodulatory-effects-of-fucoidan-against-7-12-dimethyl-benz-a-anthracene-induced-experimental-mammary-carcinogenesis-through-the-pd1-pdl1-signaling-pathway-in-rats
#2
Meilan Xue, Hui Liang, Qingjuan Tang, Chuanxing Xue, Xinjia He, Li Zhang, Zheng Zhang, Zhengyan Liang, Kang Bian, Lichen Zhang, Zhuxin Li
Fucoidan is a sulfated polysaccharide that is extracted from brown algae seaweed. This study was designed to evaluate the protective and immunomodulatory effects of dietary fucoidan on 7,12-dimethyl benz[a]anthracene (DMBA)-induced experimental mammary carcinogenesis in rats. Sixty Sprague-Dawley rats were randomly assigned to four equal groups: the control group (control group), the cancer model group (model group), and the F1 and F2 groups, which were fed fucoidan at concentrations of 200 and 400 mg/kg·body weight, respectively...
October 18, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29035593/the-impact-of-body-mass-index-and-waist-circumference-on-health-related-quality-of-life-among-colorectal-cancer-survivors-results-from-the-profiles-registry
#3
Pauline A J Vissers, Renata B Martucci, Floortje Mols, Martijn J L Bours, Renate M Winkels, Ellen Kampman, Matty P Weijenberg, Lonneke V van de Poll-Franse, Sandra Beijer
BACKGROUND: We aimed to assess the association of waist circumference (WC) and body mass index (BMI) with health-related quality of life (HRQL) among colorectal cancer (CRC) survivors. METHODS: CRC survivors diagnosed between 2000 and 2009 completed questionnaires in August 2013 (with self-reported weight, height, and self-assessed WC) and January 2014 (with HRQL using the EORTC-QLQ-C30). Clinical characteristics were retrieved from the Netherlands Cancer Registry...
October 16, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29016221/apoptotic-and-immunosuppressive-effects-of-turmeric-paste-on-7-12-di-methyl-benz-a-anthracene-induced-skin-tumor-model-of-wistar-rat
#4
R S Rajmani, Prafull Singh, Lakshya Veer Singh
Dietary components with potent anticancerous property are gaining attention as therapeutic agents due to low cost of therapy and minimal toxic effects. Turmeric is one such miracle spices of Indian and South Asian recipes with multiple medicinal properties. The anticarcinogenic properties of its active compound curcumin have been studied in detail. However, studies on the medicinal properties of crude turmeric used as dietary agents are lacking. Therefore, in this study we investigated the effects of dietary and topical crude turmeric paste on DMBA induced skin tumor of male Wistar rats...
October 10, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29016198/carcinogenicity-of-high-consumption-of-meat-and-lung-cancer-risk-among-non-smokers-a-comprehensive-meta-analysis
#5
Patrizia Gnagnarella, Saverio Caini, Patrick Maisonneuve, Sara Gandini
Increasing evidence suggests that high consumption of meat is linked to lung cancer but the previous meta-analyses did not properly address the role of tobacco smoking as a potential confounder. We conducted a meta-analysis to investigate the association of lung cancer, among never smokers, with consumption of various type of meat, fish, heterocyclic amines and polycyclic aromatic hydrocarbons. We performed a systematic literature search and meta-analysis, for highest versus lowest consumption and dose-response...
October 10, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29016197/nutritional-therapy-for-patients-with-esophageal-cancer
#6
Taja Jordan, Denis Mlakar Mastnak, Nizra Palamar, Nada Rotovnik Kozjek
Malnutrition develops in 79% patients with esophageal cancer. Thus, these patients represent a group of cancer patients, which is the most nutritionally compromised. Dysphagia and more than 10% loss of body weight are already present at the time of diagnosis. Treatments for esophageal cancer contribute significantly to the development of malnutrition. This paper describes the nutritional treatment of patients and nutritional strategies in patients with dysphagia and other nutritional problems that accompany the treatment of patients with esophageal cancer...
October 10, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28990814/induction-of-anoikis-in-human-colorectal-cancer-cells-by-fucoxanthinol
#7
Masaru Terasaki, Hayato Maeda, Kazuo Miyashita, Michihiro Mutoh
Fucoxanthin (Fx), one of the major xanthophylls in brown algae, is known to be effective for colorectal cancer (CRC) chemoprevention through inhibiting cell growth, cell cycle and caspase activation. Recently, we observed fucoxanthinol (FuOH), an anti-cancer active metabolite of Fx, treatment of human CRC cells resulted in plenty of living floating cells several hours after exposure, and induced apoptosis. In the present study, we investigated whether FuOH induced anchorage-dependent apoptosis, that is "anoikis", along with integrin signal suppression in human CRC cells...
October 9, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28976208/pomegranate-extract-alters-breast-cancer-stem-cell-properties-in-association-with-inhibition-of-epithelial-to-mesenchymal-transition
#8
Sameera Nallanthighal, Kristine M Elmaliki, Ramune Reliene
Cancer stem cells (CSCs) have become an important target population in cancer therapy and prevention due to their ability to self-renew, initiate tumors, and resist therapy. We examined whether pomegranate extract (PE) alters characteristics of breast CSCs. Ability to grow as mammospheres is a hallmark of breast CSCs. PE inhibited mammosphere formation in two different cell lines, neoplastic mammary epithelial HMLER and breast cancer Hs578T. In addition, mammosphere-derived cells from PE treatment groups showed reduced mammosphere formation for at least two serial passages...
October 4, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28952790/predictors-of-nutritional-risk-according-to-nrs-2002-and-calf-circumference-in-hospitalized-older-adults-with-neoplasms
#9
Vania Aparecida Leandro-Merhi, José Luis Braga de Aquino, Leonardo Oliveira Reis
OBJECTIVES: To investigate nutritional markers that better predict nutritional risk according to the Nutritional Risk Screening (NRS-2002), to verify agreement between indicators, and to identify the calf circumference cut-off point for diagnosing nutritional risk. METHODS: Cross-sectional study with older patients hospitalized for neoplasms. The nutritional risk was assessed by NRS-2002 and the nutritional status by Subjective Global Assessment (SGA), Mini-Nutritional Assessment (MNA long form), calf circumference (CC), and body mass index (BMI)...
September 27, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28945459/importance-of-pancreatic-enzyme-replacement-therapy-after-surgery-of-cancer-of-the-esophagus-or-the-esophagogastric-junction
#10
Thomas Kiefer, Dorothea Krahl, Kathrin Osthoff, Peter Thuss-Patience, Jörg Bunse, Ulrich Adam, Marc H Jansen, Rudolf Ott, Robert Pfitzmann, Matthias Pross, Thomas Kohlmann, Georg Daeschlein, Hermann Buhlert, Heinz Völler, Carsten Hirt
After surgical treatment of cancer of the esophagus or the esophagogastric junction we observed steatorrhea, which is so far seldom reported. We analyzed all patients treated in our rehabilitation clinic between 2011 and 2014 and focused on the impact of surgery on digestion of fat. Reported steatorrhea was anamnestic, no pancreatic function test was made. Here we show the results from 51 patients. Twenty-three (45%) of the patients reported steatorrhea. Assuming decreased pancreatic function pancreatic enzyme replacement therapy (PERT) was started or modified during the rehabilitation stay (in the following called STEA(+))...
September 25, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28945110/effects-of-obesity-on-the-regulation-of-macrophage-population-in-the-prostate-tumor-microenvironment
#11
G C Galván, C B Johnson, R S Price, M A Liss, C A Jolly, L A deGraffenried
Obesity is associated with a greater risk of prostate cancer mortality. However, the mechanisms connecting obesity to the progression of prostate cancer remain unknown. This study determined the impact of obesity on macrophage recruitment and tumor-associated macrophage (TAM) polarization in the prostate tumor microenvironment, since a high concentration of TAMs in tumors has been linked to progression in prostate cancer. We utilized an in vitro model in which pre-adipocytes, prostate cancer cells, and macrophages were exposed to sera from obese or nonobese men, or conditioned media generated under obese or nonobese conditions...
September 25, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28937804/obesity-and-endometrial-cancer-a-lack-of-knowledge-but-opportunity-for-intervention
#12
Ashley F Haggerty, David B Sarwer, Kathryn H Schmitz, Emily M Ko, Kelly C Allison, Christina S Chu
OBJECTIVE: The causal link between obesity and endometrial cancer is well established; however obese women's knowledge of this relationship is unknown. Our objective was to explore patients' understanding of this relationship and assess the acceptability of a technology-based weight loss intervention. METHODS/MATERIALS: Obese women with Type I endometrial cancer/hyperplasia were surveyed about their assessment of their body mass, knowledge of the relationship of obesity and endometrial cancer, and eating and activity habits...
September 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28937799/can-diet-modulate-helicobacter-pylori-associated-gastric-pathogenesis-an-evidence-based-analysis
#13
Syed Faisal Zaidi, Kanwal Ahmed, Sheikh Abdul Saeed, Usmanghani Khan, Toshiro Sugiyama
Helicobacter pylori is involved in the pathogenesis of gastritis, peptic ulcer, and gastric cancer. The infection is prevalent in more than half of the world's population. Although the infection may lead to detrimental consequences, still the majority of the infected individuals only develop mild gastritis. Several factors are behind this paradoxical outcome including virulence of the infecting H. pylori strains, genetic background of the host, and factors related to lifestyle such as dietary habits. Among these, lifestyle including dietary factors was not in the limelight, until recently, as one of the important factors that could modulate H...
September 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28937798/dual-effects-of-resveratrol-on-cell-death-and-proliferation-of-colon-cancer-cells
#14
Álvaro San Hipólito-Luengo, Antonio Alcaide, Mariella Ramos-González, Elena Cercas, Susana Vallejo, Alejandra Romero, Elena Talero, Carlos F Sánchez-Ferrer, Virginia Motilva, Concepción Peiró
Colorectal cancer remains a main cause of deaths worldwide, and novel agents are being searched to treat this disease. Polyphenols have emerged as promising therapeutic tools in cancer. Resveratrol (3,5,4'-trihydoxy-trans-stilbene) induces cell death in different tumor cell lines, and it also stimulates the proliferation of specific breast and prostate cancer cell lines. Here, we studied the impact of resveratrol over a 100-fold concentration range on cell death and proliferation of HT-29 colorectal adenocarcinoma cells...
September 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28937797/modified-nutrition-index-is-a-significant-prognostic-factor-for-the-overall-survival-of-the-nasopharyngeal-carcinoma-patients-who-undergo-intensity-modulated-radiotherapy
#15
Jin-Sheng Hong, Yang-Jing-Ling Hua, Li Su, Hai-Rong Zhang, Wen-Long Lv, Xiu-Ying Chen, Jun Tian, Wei-Jian Zhang
PURPOSE: To explore whether the modified-nutrition index (m-NI) is a prognostic factor for the overall survival (OS) in nasopharyngeal carcinoma (NPC) patients who undergo intensity-modulated radiotherapy (IMRT). METHODS: Clinical data were prospectively collected from NPC patients who underwent IMRT at our hospital between October 2008 and December 2014. The patient nutritional status before radiotherapy was evaluated using the m-NI, based on eight nutrition indicators including body mass index, arm muscle circumference, albumin, total lymphocyte count, red blood cell count, hemoglobin, serum pre-albumin, and transferrin...
September 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28937796/delay-of-lung-adenocarcinoma-lac-1-development-in-mice-by-dietary-oleic-acid
#16
Mariana Piegari, Elio A Soria, Aldo R Eynard, Mirta A Valentich
Lung cancer is the leading cause of death by cancer, and is a major sanitary concern worldwide. Some nutrients, such as ω-9 fatty acids, have been proposed as anticancer agents. Thus, an olein-enriched diet was assayed in a murine model of lung adenocarcinoma (LAC-1) to evaluate neoplastic and paraneoplastic evolution in BALB/c mice. The organic assimilation of dietary fatty acids was confirmed in liver by gas chromatography. This experimental oleic acid-containing diet increased animal survival and tumour latency (analysed by the Kaplan-Meier method), improving neoplastic evolution and general status, with weak effects on the paraneoplastic syndrome (thymus atrophy, splenomegaly, splenocyte response to mitogen, blood anaemia, and leucocytosis)...
September 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28937794/nutritional-status-of-hematological-patients-before-hematopoietic-stem-cell-transplantation-and-in-early-posttransplantation-period
#17
Joanna Krawczyk, Leszek Kraj, Teresa Korta, Wiesław Wiktor-Jędrzejczak
Hematopoietic stem cell transplantation (HSCT) is an aggressive method of treatment affecting patient's homeostasis. The aim of the study was to evaluate the initial nutritional status of HSCT patients and nutritional status in early posttransplantation period. The prospective study included 100 consecutive patients with hematological malignancies subjected to HSCT. The nutritional status evaluation was made using the nutritional screening scales, anthropometric and biochemical parameters, as well. On the day +7 following HSCT significant decrease in concentration of total protein (5...
September 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28937793/investigating-the-antiangiogenic-anti-drug-resistance-and-apoptotic-effects-of-soy-isoflavone-extract-alone-or-in-combination-with-docetaxel-on-murine-4t1-breast-tumor-model
#18
Ehsan Hejazi, Maryam Tavakoli, Mahmood Jeddi-Tehrani, Masoud Kimiagar, Jalal Hejazi, Mohammad Houshyari, Zohre Amiri, Hale Edalatkhah, Javad Nasrollahzadeh, Farah Idali
BACKGROUND: One major concern in the treatment of cancer patients during chemotherapy is drug resistance. Here we investigated the effects of soy isoflavone extracts alone or in combination with Docetaxel on the drug resistance, angiogenesis, apoptosis, and tumor volume in mouse 4T1 breast tumor model. METHODS: Sixty female BALB/c mice were randomly divided into 4 groups: control, dietary soy isoflavone extract [Iso, 100 mg/kg diet (0.01%)], Docetaxel (10 mg/kg) injection, and the combination of dietary soy isoflavone extract and intravenous Docetaxel injection (Docetaxel + Iso)...
September 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28937788/lipid-extracts-from-the-brains-of-silver-carp-hypophthalmichthys-molitrix-induce-apoptosis-in-mcf-7-cells-through-the-generation-of-reactive-oxygen-species-and-the-mitochondrial-pathway
#19
Caixia Wang, Wenshui Xia, Qixing Jiang, Yanshun Xu, Peipei Yu
Previous studies have verified the protective role of n3 polyunsaturated fatty acids (PUFAs) in cancer. Fish brain lipids are rich in n3 PUFAs. However, the action and mechanism of their potent anticancer activities remain unclear. In this study, polar lipids (PLs) and neutral lipids (NLs) were isolated from the total lipids (TLs) of the silver carp brain, and the anticancer effects of the lipid fractions (LFs) were examined in a human breast cancer cell line (MCF-7). The LFs effectively inhibited the cell proliferation of MCF-7 cells in a time- and concentration-dependent manner by cell cycle arrest at the S stage and induction of apoptosis...
September 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28922017/effects-of-chronic-and-intermittent-calorie-restriction-on-adropin-levels-in-breast-cancer
#20
Bilge G Tuna, Pinar B Atalay, Mine Altunbek, Batuhan M Kalkan, Soner Dogan
Adropin is a peptide hormone that has been implicated in insulin resistance and as a potential regulator of growth. The aim of this study is to determine the effect of calorie restriction on circulating levels of adropin in the MMTV-TGFα breast cancer mouse model and investigate the effects of adropin peptide on the viability of MCF-7 and MDA-231 breast cancer cells in culture. Ten-week-old mice were assigned to either ad libitum-fed (AL), chronic calorie-restricted, or intermittent calorie-restricted groups...
September 18, 2017: Nutrition and Cancer
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