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Nutrition and Cancer

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https://www.readbyqxmd.com/read/29220587/fto-gene-affects-obesity-and-breast-cancer-through-similar-mechanisms-a-new-insight-into-the-molecular-therapeutic-targets
#1
M E Akbari, M Gholamalizadeh, S Doaei, F Mirsafa
OBJECTIVES: This review focused on the possible mediatory role of the FTO in the association between obesity and breast cancer. METHOD: All articles published in English from June 1990 to January 2017 were studied. The search terms used were FTO gene, FTO polymorphism, breast cancer, and obesity. Inclusion criteria consisted of assessment of the relationship between FTO polymorphisms and/or FTO expression level with obesity and/or breast cancer as a primary outcome...
December 8, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29220583/elevated-serum-vitamin-b12-levels-as-a-prognostic-factor-for-survival-time-in-metastatic-cancer-patients-a-retrospective-study
#2
Hye Kyung Oh, Jee Young Lee, Wan Kyu Eo, Seong Woo Yoon, Sung Nim Han
BACKGROUND: Serum vitamin B12 levels have been proposed as one of the survival prediction factors, although no survival analysis in metastatic cancer patients has been conducted yet. This study examined whether serum vitamin B12 levels could be a prognostic factor in metastatic cancer patients. METHODS: Data from a retrospective chart review were used to perform Kaplan-Meier and multivariate analyses of the Cox proportional hazards. Subgroup analysis was performed on patients without a liver lesion (hepatocellular carcinoma or liver metastasis)...
December 8, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29166141/adherence-to-the-wcrf-aicr-for-women-in-breast-cancer-adjuvant-treatment-submitted-to-educational-nutritional-intervention
#3
Sheyla de Liz, Francilene Gracieli Kunradi Vieira, Maria Alice Altenburg de Assis, Alyne Lizane Cardoso, Clarice Perucchi Lopes Pazini, Patricia Faria Di Pietro
Patients undergoing breast cancer treatment are susceptible to changes in eating behavior and nutrition status, thus making nutrition education relevant. Based on the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guide, with recommendations for cancer prevention released in 2007, the present study aimed to evaluate the effectiveness of educational nutritional intervention for women with breast cancer undergoing treatment while adhering to the 2007 WCRF/AICR guidelines. A nonrandomized clinical trial was conducted with a population composed of female patients, divided in intervention (IG, n = 18) and comparison (CG, n = 68) groups...
November 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29166139/acknoweldgment-to-reviewers
#4
(no author information available yet)
No abstract text is available yet for this article.
November 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29161179/synergistic-induction-of-apoptosis-by-quercetin-and-curcumin-in-chronic-myeloid-leukemia-k562-cells
#5
Ergül Mutlu Altundağ, Ayşe Mine Yılmaz, Semra Koçtürk, Yavuz Taga, A Suha Yalçın
Chronic myeloid leukemia is a major hematopoietic malignancy characterized by expansion of myeloid cells. In this study, we have investigated whether quercetin, curcumin and their combination induce apoptosis and inhibit growth of K562 cells. We have observed that quercetin and curcumin combination induced apoptosis accompanied by increased ROS and decreased GSH levels as well as loss of mitochondrial membrane potential. Our mRNA and protein expression results suggested that cytochrome c was released from mitochondria causing PARP and caspase-9 cleavages, the hallmarks of mitochondrial apoptotic pathway...
November 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29161168/eov-editorial-board
#6
(no author information available yet)
No abstract text is available yet for this article.
November 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29148840/resveratrol-induces-mitochondrial-apoptosis-and-inhibits-epithelial-mesenchymal-transition-in-oral-squamous-cell-carcinoma-cells
#7
Seong-Eon Kim, Sang-Hun Shin, Jae-Yeol Lee, Chul-Hoon Kim, In-Kyo Chung, Hae-Mi Kang, Hae-Ryoun Park, Bong-Soo Park, In-Ryoung Kim
OSCC is the most common malignant cancer of the head and neck. EMT is an essential cellular process critical to the morphogenesis and homeostasis of solid tissues. It is also involved in the initial stage of cancer metastasis and invasion in which cells lose epithelial characteristics. While cancer therapy protocols such as surgery, radiation, and chemotherapy are effective and useful, the drug tolerance and toxicity of OSCC patients remain a problem. Resveratrol is mainly produced in red grape skin and exhibits anti-oxidative, anti-inflammatory, anti-proliferative, and anti-cancer properties...
November 17, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29144773/cancer-chemopreventive-antiproliferative-and-superoxide-anion-scavenging-properties-of-kluyveromyces-marxianus-and-saccharomyces-cerevisiae-var-boulardii-cell-wall-components
#8
Olivier Fortin, Blanca Aguilar-Uscanga, Khanh Dang Vu, Stephane Salmieri, Monique Lacroix
This study investigated the cancer chemopreventive, the antiradical, and the antiproliferative properties of polysaccharides extracts from cell wall of Saccharomyces boulardii and Kluyveromyces marxianus. β-glucan, mannan, and chitin were also quantified to identify the most important extract responsible for these biological properties. Soluble and insoluble glucans as well as mannoprotein were extracted from cell wall using single hot-alkaline method. Superoxide anion scavenging (antiradical capacity), NAD(P)H: quinone reductase (QR) (EC 1...
November 16, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29140733/proinflammatory-dietary-intake-is-associated-with-increased-risk-of-colorectal-cancer-results-of-a-case-control-study-in-argentina-using-a-multilevel-modeling-approach
#9
Camila Niclis, Sonia A Pou, Nitin Shivappa, James R Hébert, Susan E Steck, María Del Pilar Díaz
Little evidence regarding the inflammatory potential of diet and its effect on colorectal cancer exists in Latin American countries. The aim of the present study was to evaluate the association between the Dietary Inflammatory Index (DII®) and colorectal cancer (CRC) risk in Córdoba, Argentina. A frequency-matched case-control study (N = 446, including 144 (32.3%) CRC cases and 302 (67.7%) controls was conducted in Córdoba (Argentina) from 2008 through 2015. DII® scores were computed based on dietary intake assessed by a validated food frequency questionnaire (FFQ)...
November 15, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29125314/associations-of-calcium-and-dairy-products-with-all-cause-and-cause-specific-mortality-in-the-reasons-for-geographic-and-racial-differences-in-stroke-regards-prospective-cohort-study
#10
Caroline Y Um, Suzanne E Judd, W Dana Flanders, Veronika Fedirko, Roberd M Bostick
Associations of calcium and dairy product intakes with cardiovascular disease risk and cancer mortality are controversial. We investigated associations of calcium and dairy product intakes with mortality in the prospective REasons for Geographic and Racial Differences in Stroke study (n = 30,239). Of 2,966 total deaths, 32.3% were from CVD and 28.8% from cancer. For those in the upper relative to the lowest quintile of intakes, from Cox proportional hazards regression models, the multivariable-adjusted hazard ratios (HRs) for all-cause mortality were 1...
November 10, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29111814/sarsaparilla-smilax-glabra-rhizome-extract-activates-redox-dependent-atm-atr-pathway-to-inhibit-cancer-cell-growth-by-s-phase-arrest-apoptosis-and-autophagy
#11
Tiantian She, Junnan Feng, Shenyi Lian, Ruobing Li, Chuanke Zhao, Guoliang Song, Jie Luo, Rouxianguli Dawuti, Shaoqing Cai, Like Qu, Chengchao Shou
Sarsaparilla (Smilax Glabra Rhizome) exerts growth inhibitory effect on multiple cancer cells in vitro and in vivo, and redox-dependent persistent activation of ERK1/2 has been reported to underlie this effect. Here, we report an activation of ATM/ATR-dependent signaling pathway also as a mechanism for the cancer cell growth inhibition induced by the supernatant fraction of the water-soluble extract from sarsaparilla (SW). SW treatment (3.5 μg/μL) promoted the phosphorylations of ATM, ATR, and CHK1 in AGS and HT-29 cells...
November 7, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29111787/performance-status-prognostic-scoring-and-parenteral-nutrition-requirements-predict-survival-in-patients-with-advanced-cancer-receiving-home-parenteral-nutrition
#12
Niamh Keane, Konstantinos C Fragkos, Pinal S Patel, Friderike Bertsch, Shameer J Mehta, Simona Di Caro, Farooq Rahman
We describe a cohort of Home Parenteral Nutrition (HPN) patients with advanced cancer in order to identify factors affecting prognosis. Demographic, anthropometric, biochemical and medical factors, Karnofsky Performance Status (KPS), Glasgow Prognostic Score (GPS), and PN requirements were recorded. Univariate and multivariate analyses were performed including Kaplan-Meier curves, Cox Regression, and correlation analyses. In total, 107 HPN patients (68 women, 39 men, mean age 57 yr) with advanced cancer were identified...
November 7, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29111786/active-hexose-correlated-compound-ahcc-inhibits-the-proliferation-of-ovarian-cancer-cells-by-suppressing-signal-transducer-and-activator-of-transcription-3-stat3-activation
#13
Jin Young Choi, Seul Lee, Sun-Mi Yun, Dong Hoon Suh, Kidong Kim, Jae Hong No, Eun-Hwan Jeong, Yong Beom Kim
The purpose of this study was to investigate the antiproliferative effect of active hexose correlated compound (AHCC), derived from basidiomycete mushroom culture, on ovarian cancer cell lines. An in vitro growth inhibition assay was performed using AHCC in ovarian cancer cell lines. Western blotting was performed to investigate the mechanism of the observed antiproliferative effect of AHCC. We identified that ovarian cancer cell viability was significantly reduced through treatment with AHCC compared to that in the control...
November 7, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29111778/multi-carotenoids-at-physiological-levels-inhibit-vegf-induced-tube-formation-of-endothelial-cells-and-the-possible-mechanisms-of-action-both-in-vitro-and-ex-vivo
#14
Chien-Hao Huang, Chin-Shiu Huang, Miao-Lin Hu, Cheng-Hung Chuang
Carotenoids have been shown to exhibit antiangiogenic activities. Several studies have indicated that carotenoids used in combination were more effective on antioxidation and anticancer actions than carotenoids used singly. However, it is unclear whether multi-carotenoids have antiangiogenic effects. We investigated the effects of multi-carotenoids at physiological plasma levels of Taiwanese (abbreviated as MCT, with a total of 1.4 μM) and Americans (abbreviated as MCA, with a total of 1.8 μM), and of post-supplemental plasma levels (abbreviated as HMC with a total of 3...
November 7, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29095048/equol-enhances-apoptosis-inducing-activity-of-genistein-by-increasing-bax-bcl-xl-expression-ratio-in-mcf-7-human-breast-cancer-cells
#15
Misaki Ono, Kaoru Ejima, Takako Higuchi, Mikako Takeshima, Rei Wakimoto, Shuji Nakano
Anticancer activities of soy isoflavones, such as genistein and equol, a bioactive metabolite of daidzein, have been extensively studied because of possible involvement in the prevention of breast cancer. However, their interactions still remain unclear. We investigated here whether cytotoxic activity of genistein was enhanced by equol, using estrogen receptor positive MCF-7, HER2-positive SK-BR-3, and triple-negative MDA-MB-468 cell lines. Although cytotoxicity of genistein did not significantly differ between three subtypes of breast cancer cells, cytotoxic activities of genistein were significantly enhanced in combination with 50 μM equol in MCF-7 cells, but not in SK-BR-3 and MDA-MB-468 cells...
November 2, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29087221/association-between-dietary-inflammation-index-and-the-risk-of-colorectal-cancer-a-meta-analysis
#16
Caixia Zhang, Weijing Wang, Dongfeng Zhang
OBJECTIVES: We performed a meta-analysis to assess the association and possible dose-response relationship between dietary inflammation index (DII)™ and colorectal cancer (CRC). METHODS: A literature search was performed in PubMed, Web of Science and Chinese National Knowledge Infrastructure (CNKI) database for all relevant studies. The pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated by random effects model. RESULTS: A total of eight studies were included in this meta-analysis...
October 31, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29083245/assessment-and-impact-of-phase-angle-and-sarcopenia-in-palliative-cancer-patients
#17
Dana A Pérez Camargo, Silvia R Allende Pérez, Emma Verastegui Avilés, Mónica M Rivera Franco, Abelardo Meneses García, Ángel Herrera Gómez, Víctor I Urbalejo Ceniceros
Sarcopenia has been evaluated as a separate condition in cancer patients and as an important indicator of adverse outcomes. Muscle mass and phase angle are usually quantified by bioelectrical impedance analysis, due to its lower cost, and availability. The aim of this study was to assess the impact of sarcopenia, phase angle, and other characteristics on overall survival (OS) in palliative cancer patients at the National Cancer Institute of Mexico. We enrolled 628 patients (female, 59%). The most frequent disease was gastric cancer (39...
October 30, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29083244/intake-of-individual-flavonoids-and-risk-of-carcinogenesis-overview-of-epidemiological-evidence
#18
Katrin Sak
Several epidemiological findings have demonstrated that specific flavonoids can be responsible for reduction of the risk of certain cancer types. However, these results are still rather limited, inconclusive and controversial. Therefore, in this comprehensive review article the findings reported to date about the associations between dietary intake of individual flavonoid compounds and cancer incidence are compiled and analyzed. Also, the possible reasons for inconsistencies are brought forth and discussed...
October 30, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29083243/prospective-evaluation-of-nutritional-factors-to-predict-the-risk-of-complications-for-patients-undergoing-radical-cystectomy-a-cohort-study
#19
Janie Allaire, Caroline Léger, Tal Ben-Zvi, Molière Nguilé-Makao, Yves Fradet, Louis Lacombe, Vincent Fradet
The objective of this study was to identify nutritional preoperative factors associated with complications after radical cystectomy (RC). We prospectively evaluated the Mini-Nutritional Assessment Score, body mass index (BMI), appetite, stool frequency, hydration, food intake, weight loss, albuminemia, and prealbuminemia of 144 patients who underwent RC between January 2011 and April 2014. Postoperative complications were defined as any adverse event reported in the patient's file up to 90 days after surgery...
October 30, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29083238/critical-weight-loss-in-patients-with-oropharynx-cancer-during-radiotherapy-%C3%A2-chemotherapy
#20
Belinda Vangelov, Rebecca L Venchiarutti, Robert I Smee
Critical weight loss (CWL) defined as ≥5% in one month, is common in patients with oropharynx cancer and identification of patients at risk is challenging. We aimed to investigate if predictors of CWL in this population exist to guide nutritional intervention. Data were collected retrospectively on 134 patients who had radiotherapy (RT) ± concurrent chemotherapy (CRT) ± surgery. Body weights were collected pre-RT and during RT, with percentage weight change measured against baseline. Logistic regression was used to analyze chosen predictors...
October 30, 2017: Nutrition and Cancer
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