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Nutrition and Cancer

Radosław Chaber, Elżbieta Latos-Grażyńska, Krzysztof Ciebiera, Kornelia Łach, Barbara Tokar, Józef Cebulski, Katarzyna Trybucka, Artur Mazur
The incidence of treatment related mortality in children with acute lymphoblastic leukemia (ALL) is reported to be between 2% and 4% with infections being the leading cause. AIM: To establish a relationship between body mass index at diagnosis (BMI 0), after protocol I therapy completion (BMI I) and the incidence rate ratio (IRR) of infectious/febrile episodes in children with ALL intermediate risk. METHODS: Thirty one consecutive patients (2-18 years old, with a male to female ratio of 19/12) with newly diagnosed ALL that were treated uniformly according to ALL IC 2009 protocol were included in this analysis...
November 8, 2018: Nutrition and Cancer
Muayad Mehdi Abboud, Wajdy Al Awaida, Hakam Hasan Alkhateeb, Asia Numan Abu-Ayyad
The treatment of MCF-7 and T47D human breast cancer cell lines with amygdalin was able to reduce the growth of both cells, in concentration and time-dependent manners. The potency of this inhibition against MCF-7 and T47D cells produced IC50 values of 39 and 45 mM, respectively. To investigate the correlation of this inhibition with oxidative stress, an amygdalin treatment of both cell lines was capable of inducing the generation of malondialdehyde (MDA) and oxidized glutathione levels. Also, this treatment caused the decrease of total glutathione and glutathione reductase activity...
November 8, 2018: Nutrition and Cancer
Vicky C Chang, Michelle Cotterchio, Beatrice A Boucher, David J A Jenkins, Lucia Mirea, Susan E McCann, Lilian U Thompson
Lignan intake, and its richest food source, flaxseed, have been associated with reduced breast cancer risk. Endogenous sex hormones, such as estrogens, play a role in breast cancer development, and lignans may alter these sex hormone levels. To assess the effect of flaxseed on circulating sex hormones, a randomized controlled trial was conducted among 99 postmenopausal women in Toronto, Canada. The intervention arm consumed 2 tablespoons (15 g) of ground flaxseed daily for 7 weeks; the control arm maintained usual diet...
October 30, 2018: Nutrition and Cancer
Smitha Padmanabhan, Mostafa I Waly, Varna Taranikanti, Nejib Guizani, Amanat Ali, Mohammad S Rahman, Zaher Al-Attabi, Raya N Al-Malky, Sultan N M Al-Maskari, Bader R S Al-Ruqaishi, Jianan Dong, Richard C Deth
Folate and vitamin B12 deficiency is associated with depletion of the major intracellular antioxidant glutathione, and oxidative stress is emerging as an etiological mechanism for colon cancer. Azoxymethane (AOM), a potent carcinogen, induces colon cancer in rats by causing pathophysiological changes and oxidative stress. We investigated the synergistic effect of folate and vitamin B12 supplementation against AOM-induced carcinogenesis and oxidative stress in rat colon. Adult male rats were distributed into four groups: 1) Basal diet only; 2) AOM injection (15 mg/kg once per week in weeks 5 and 6); 3) Folate and vitamin B12 supplemented diet; 4) Folate and B12 diet with AOM injection...
October 29, 2018: Nutrition and Cancer
Jin Wang, Li Shao, Chong-Zhi Wang, Hong-Hao Zhou, Chun-Su Yuan, Wei-Hua Huang
Although irinotecan is an important anticancer drug for treating colorectal cancer, its dose-dependent side effects limited its clinical application. Thus, it's important to develop low-toxic candidates to enhance the efficacy of irinotecan. Polyynes from genus Oplopanax were reported to possess potential anticancer effects on colorectal cancer. Hereby, we evaluated the synergetic inhibition of human colorectal cancer cells by combining polyyne-enriched fraction from Oplopanax elatus (the dichloromethane fraction of Oplopanax elatus, OED) and irinotecan...
October 29, 2018: Nutrition and Cancer
Xin Yin, Roberd M Bostick
INTRODUCTION: Consumption of nuts, which contain multiple anti-carcinogenic components, has been inversely associated with colorectal cancer (CRC), particularly among women, but has not been investigated in relation to colorectal adenoma, the immediate precursor to most CRCs. METHODS: We pooled data from three case-control studies of incident, sporadic colorectal adenoma (n = 785 cases, 2107 controls) in which dietary intakes were assessed using food frequency questionnaires, and analyzed the data using multivariable unconditional logistic regression...
October 29, 2018: Nutrition and Cancer
Mohsen Tatar, Zohreh Bagheri, Masoumeh Varedi, Fakhraddin Naghibalhossaini
Several mechanisms have been proposed to explain berries' anticancer effects. However, no previously published studies have investigated berries' anti-telomerase activity. In this study, the anti-telomerase activity of blackberry crude extract was analyzed in six human colorectal cancer (CRC) cell lines by TRAP assay. The peripheral blood mononuclear cells (PBMCs) from a healthy donor were used as a normal control. We also examined the effect of blackberry on the human telomerase RNA (hTR) mRNA level and on human telomerase reverse transcriptase (hTERT) expression and promoter methylation in CRC cells...
October 29, 2018: Nutrition and Cancer
Paulo Victoria Soares, Vinicius Kannen, Alceu Afonso Jordão Junior, Sergio Britto Garcia
Colorectal cancer (CRC) is the third most frequent malignancy worldwide. Coffee is the second most consumed drink in the globe and suggested to decrease the CRC risk. Here, we explored whether coffee, decaffeinated coffee, or caffeine impact on the development of colorectal carcinogenesis induced by the direct carcinogen N-methyl-N-nitro-N-nitrosoguanidine (MNNG) in rats. To this end, sixty-four young male Wistar rats were divided into eight groups of eight animals each. We analyzed the frequency of dysplastic crypts and expression of metallothionein as a biomarker of the cancer risk, as well the expression of phosphorylated H2A histone family/member X (γH2AX) for DNA damage and cyclooxygenase-2 (COX-2) for inflammatory response...
October 26, 2018: Nutrition and Cancer
Lei Li, Feifei Shang, Yadong Zhu, Yanfu Sun, Radha Sharan Sudi
Many in vitro studies support the general idea that vitamin D plays a protective role against cancer. Increased doses of vitamin D dietary supplements have been widely used for the potential anticancer benefits of vitamin D. However, despite substantial epidemiological research, there are no clear conclusive data to support the use of vitamin D as a cancer preventive or treatment agent. In the, herein, reported study, we checked the effects of 1,25-dihydroxyvitamin D3 concentrations on the expression level of the vitamin D receptor (VDR) and cell cycle-related proteins CDKN1A (p21) and CDK1 in pancreatic cells and Panc-1 pancreatic cancer (PC) cells...
October 25, 2018: Nutrition and Cancer
Alireza Milajerdi, Nazli Namazi, Bagher Larijani, Leila Azadbakht
This study aimed to systematically review and do a meta-analysis on available evidence on the association of diet quality indices with cancer mortality. We searched for relevant papers published up to August 2017 through Web of science, PubMed/Medline, Scopus, and Google Scholar. Prospective cohort studies examined the association of any dietary quality indices with cancer mortality were included. Overall, 27 publications were included. There was significant inverse associations between the Dietary Approaches to Stop Hypertension (DASH) diet (HR: 0...
October 15, 2018: Nutrition and Cancer
Alireza Dadfarma, Mehdi Shayanfar, Sanaz Benisi-Kohansal, Minoo Mohammad-Shirazi, Giuve Sharifi, Saeed Hosseini, Ahmad Esmaillzadeh
This study aimed to assess the association of dietary polyunsaturated fatty acid (PUFA) and risk of glioma among the Iranian population. A case-control study carried out among 128 newly diagnosed glioma adult patients with pathologically confirmed samples along with 256 sex- and age-matched controls. Dietary intake was examined by means of a validated semiquantitative food frequency questionnaire (FFQ). Total PUFA intake was computed by summing up dietary PUFAs from all food items in the questionnaire. Participants were categorized based on quartile cut-points of dietary PUFA intake...
October 15, 2018: Nutrition and Cancer
Theodora Psaltopoulou, Ioannis Ntanasis-Stathopoulos, Diamantis I Tsilimigras, Ioannis-Georgios Tzanninis, Maria Gavriatopoulou, Theodoros N Sergentanis
There has been accumulating evidence that several micronutrients may play a protective role in the risk of solid cancers. However, their role in hematological malignancies remains to be elucidated; this meta-analysis aims to evaluate the associations between micronutrient intake as well as supplementation and risk of hematological cancer in adults. Eligible cohort studies (examining intake of vitamin A, vitamin C, vitamin D, vitamin E, lycopene, folate, iron, carotenoids, beta-carotene, selenium, pyridoxine) were sought in PubMed up to July 31, 2016...
October 5, 2018: Nutrition and Cancer
Shiwangni Rao, Abishek B Santhakumar, Kenneth A Chinkwo, Thiru Vanniasinkam, Jixun Luo, Christopher L Blanchard
It has been identified that diet is one of the major contributing factors associated with the development of cancer and other chronic pathologies. In the recent years, supplementing regular diet with food and/or its components that contain chemopreventive properties has been considered an effective approach in reducing the incidence of cancer and other lifestyle associated diseases. This systematic review provides an exhaustive summary of the chemopreventive properties exhibited by everyday dietary ingredients such as rice, barley, oats, and sorghum...
October 1, 2018: Nutrition and Cancer
Nadia Saadat, Sarah Akhtar, Arvind Goja, Nurul H Razalli, Andreea Geamanu, Doina David, Yimin Shen, Smiti Vaid Gupta
Pancreatic cancer (PC) patients have poor prognosis and survival rate. Gemcitabine, the drug of choice has a dismal 15% response rate. Earlier, we reported that Garcinol alone and in combination with gemcitabine showed a dose-dependent favorable response on PC cell lines. This study probes the in vivo effects of dietary Garcinol on PC progression in transgenic PC mice (KPC; K-ras and p53 conditional mutant). KPC male mice were divided into: KC- Control diet; KGr-0.05% Garcinol diet; KGm-Gemcitabine injected; KGG - Garcinol diet + Gemcitabine injected groups...
October 1, 2018: Nutrition and Cancer
Jenny Georgina Turcott, Luis F Oñate-Ocaña, Giovanny Soca-Chafre, Laura-Alejandra Ramírez-Tirado, Diana Flores-Estrada, Zyanya Lucia Zatarain-Barrón, Oscar Arrieta
Lung cancer (LC) has a high rate of anorexia, which negatively affects quality-of-life and prognosis; however prevalence values may vary as per diagnostic test. There is no standard for anorexia diagnosis, currently the anorexia cachexia scale (A/CS) has been proposed as a tool for diagnosing anorexia with a consensus cutoff value of ≤24, nonetheless a validated cutoff value is required. The A/CS was evaluated in advanced Non-Small Cell Lung Cancer (NSCLC) patients to establish a cutoff value. The appetite item from the QLQ-C30 questionnaire and survival served as a standard reference...
October 1, 2018: Nutrition and Cancer
Reza Mohseni, Soheil Abbasi, Fatemeh Mohseni, Fateme Rahimi, Shahab Alizadeh
BACKGROUND: Diet is a known source of pro- and anti-inflammatory mediators, and inflammatory markers have been associated with mechanisms involved in prostate cancer initiation and progression. The Dietary Inflammatory Index (DII® ) is a tool to assist researchers in determining the inflammatory potential of diet. The aim of this study was to conduct a meta-analysis to assess the association between DII and prostate cancer. METHODS: EMBASE and MEDLINE were searched from inception to February 2018, for relevant observational studies...
October 1, 2018: Nutrition and Cancer
Benedikt Kramer, Angela Wenzel, Maja Boerger, Burkard Lippert, Klaus Feist, Renate Petrasch, Randolf Riemann, Karl Hoermann, Christoph Aderhold
Disease and therapy of head and neck cancer impair quality of life (QOL). QOL varies profoundly during therapy and follow-up. AIM: We sought to monitor QOL and nutritional status of patients before, during and after therapy (AT). PATIENTS AND METHODS: This study evaluates QOL by using the EORTC-questionnaires QLQ-C30 and H&N35, body weight and plasma albumin up to two years AT. RESULTS: Chemoradiotherapy is the period of the most profound QOL-impairment...
October 1, 2018: Nutrition and Cancer
Hyeonji Kim, Jeong Yong Moon, Supawadee Burapan, Jaehong Han, Somi Kim Cho
Kaempferia parviflora (KP) is a famous medicinal plant from Thailand, and is a rich source of various kinds of methoxyflavones (MFs). Many kinds of food products such as tea, capsule, and liquor are manufactured from the rhizomes of KP. In this study, KP infusions were prepared with different brewing conditions, and the amounts of three major methoxylflavones, 5,7-dimethoxyflavone (DMF), 5,7,4'-trimethoxyflavone (TMF), and 3,5,7,3',4'-pentamethoxyflavone (PMF), were analyzed. The antiproliferative activities of DMF, TMF, and PMF isolated from the brewed tea samples were evaluated...
October 1, 2018: Nutrition and Cancer
Fatemeh Sedaghat, Zeinab Heidari, Saba Jalali, Azam Doustmohammadian, Mehdi Ehteshami, Bahram Rashidkhani
BACKGROUND: The role of dietary quality indexes for predicting breast cancer (BrCa) risk remains inconclusive. We aimed to assess the relation between healthy eating index 2010 (HEI-2010) and BrCa risk in a case-control study in Iranian women. METHOD: The 272 hospitalized controls and 136 newly diagnosed BrCa cases were recruited from two major hospitals. Food frequency questionnaire (FFQ) data were then utilized to calculate the HEI-2010 scores. Logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CIs) between tertiles of HEI-2010 and BrCa risk, adjusting for potential confounders...
October 1, 2018: Nutrition and Cancer
Dimitrios Giakoumettis, Chryssa Pourzitaki, Theofanis Vavilis, Anastasia Tsingotjidou, Anastasia Kyriakoudi, Maria Tsimidou, Marina Boziki, Antonia Sioga, Nikolaos Foroglou, Aristeidis Kritis
Crocus sativus L., a dietary herb, has been used for various diseases including cancer. This is an in vitro study investigating the antineoplastic effect of the extract of the plant against C6 glioma rat cell line. The mechanism of cellular death and the synergistic effect of the extract with the alkylating agent temozolomide (TMZ) were investigated. Cellular viability was examined in various concentrations of the extract alone or in combination with TMZ. Apoptosis was determined with flow cytometry and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and autophagy by western blotting of the light chain 3 (LC3)-II...
October 1, 2018: Nutrition and Cancer
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