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Nutrition and Cancer

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https://www.readbyqxmd.com/read/28323500/strategies-to-target-glucose-metabolism-in-tumor-microenvironment-on-cancer-by-flavonoids
#1
Gang Wang, Jun-Jie Wang, Rui Guan, Li Du, Jing Gao, Xing-Li Fu
The imbalance between glucose metabolism and cancer cell growth in tumor microenvironment (TME), which are closely related with the occurrence and progression of cancer. Accumulating evidence has demonstrated that flavonoids exert many biological properties, including antioxidant and anticarcinogenic activities. Recently, the roles and applications of flavonoids, particularly in relation to glucose metabolism in cancers, have been highlighted. Thus, the identification of flavonoids targeting alternative glucose metabolism pathways in TME may represent an attractive approach to the more effective therapeutic strategies for cancer...
March 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28323499/antiproliferative-activity-of-egg-yolk-peptides-in-human-colon-cancer-cells
#2
Marwa N Yousr, Akram A Aloqbi, Ulfat M Omar, Nazlin K Howell
Egg yolk peptides were successfully prepared from egg yolk protein by-products after lecithin extraction. Defatted egg yolk protein was hydrolyzed with pepsin and pancreatin and purified by gel filtration to produce egg yolk gel filtration fraction (EYGF-33) with antiproliferative activity. The highlight of this study was that the peptide EYGF-33 (1.0 mg/ml) significantly inhibits cell viability of colon cancer cells (Caco-2) with no inhibitory effects on the viability of human colon epithelial normal cells (HCEC) after 48 h...
March 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28323490/triterpenoid-acids-as-important-antiproliferative-constituents-of-european-elderberry-fruits
#3
Michał Gleńsk, Elżbieta Czapińska, Marta Woźniak, Ireneusz Ceremuga, Maciej Włodarczyk, Grzegorz Terlecki, Piotr Ziółkowski, Ewa Seweryn
In Europe, both the fruits and flowers of Sambucus nigra L. have been used against cold, as well as laxative, diaphoretic, and diuretic remedies. There are also a number of commercially available food products that contain elderberry juice, puréed or dried elderberries. Recent comprehensive literature data on pharmacology and chemistry of Sambuci fructus have encouraged us to screen extracts with different polarities from this plant material against cancer cell lines. The cytotoxic activity of the ethyl acetate and aqueous acetone extracts from elderberries as well as detected triterpenoids on human colon adenocarcinoma cell line (LoVo) and human breast cancer cell line (MCF-7) was investigated by sulforhodamine B assay...
March 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28323486/enterolactone-induces-g1-phase-cell-cycle-arrest-in-nonsmall-cell-lung-cancer-cells-by-downregulating-cyclins-and-cyclin-dependent-kinases
#4
Shireen Chikara, Kaitlin Lindsey, Harsharan Dhillon, Sujan Mamidi, Jeffrey Kittilson, Melpo Christofidou-Solomidou, Katie M Reindl
Flaxseed is a rich source of the plant lignan secoisolariciresinol diglucoside (SDG), which is metabolized into mammalian lignans enterodiol (ED) and enterolactone (EL) in the digestive tract. The anticancer properties of these lignans have been demonstrated for various cancer types, but have not been studied for lung cancer. In this study, we investigated the anticancer effects of EL for several nonsmall cell lung cancer (NSCLC) cell lines of various genetic backgrounds. EL inhibited the growth of A549, H441, and H520 lung cancer cells in concentration- and time-dependent manners...
March 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28323480/creatine-supplementation-and-doxorubicin-induced-skeletal-muscle-dysfunction-an-ex-vivo-investigation
#5
Eric C Bredahl, David S Hydock
Supplementing the diet with creatine (Cr) to manage chemotherapy-induced skeletal muscle weakness and fatigue has potential, but little has been done exploring it as an intervention. This study examined the effects of Cr on skeletal muscle dysfunction induced by the chemotherapy drug doxorubicin (Dox). Soleus and extensor digitorum longus (EDL) from male Sprague-Dawley rats maintained in an organ bath were incubated in Krebs-Henseleit (KH) buffer with or without creatine monohydrate (25 mM) for 30 min. Skeletal muscle was then incubated in KH buffer with or without Dox (24 μM) for an additional 30 min...
March 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28323443/impact-of-abdominal-adipose-depots-and-race-on-risk-for-colorectal-cancer-a-case-control-study
#6
Sandra L Gomez-Perez, Vivek Chaudhry, Winnie Mar, Bimal Patel, Giamila Fantuzzi, Sally Freels, Carol A Braunschweig
Visceral adipose tissue (VAT) but not subcutaneous adipose tissue (SAT) is associated with obesity-related diseases including colorectal cancer (CRC). Superficial SAT (SSAT) and deep SAT (DSAT), components of SAT, also appear to independently influence disease risk. These abdominal adipose tissues (AATs) are not extensively studied in connection with CRC and have not been explored in the United States despite known racial variations in body composition. We conducted a case-control study that compared associations between AAT with CRC risk and race of African-American (AA) and non-Hispanic white (NHW) men with incident CRC matched by age, body mass index, and race (N = 158, 79/group)...
March 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28323438/green-tea-polyphenols-inhibit-colorectal-tumorigenesis-in-azoxymethane-treated-f344-rats
#7
Xingpei Hao, Hang Xiao, Jihyeung Ju, Mao-Jung Lee, Joshua D Lambert, Chung S Yang
In studying the cancer-preventive activities of green tea polyphenols, we previously demonstrated that dietary administration of polyphenon E (PPE) inhibited the formation of aberrant crypt foci (ACF) in the colon of azoxymethane (AOM)-treated F344 rats. Herein, we reported cancer-preventive activity of PPE using colorectal cancer as an end point. F344 rats were given two weekly injections of AOM, and then maintained on a 20% high-fat diet with or without 0.24% PPE for 34 wk. In the control group, 83% of rats developed colorectal tumors...
March 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28323437/potato-consumption-and-risk-of-colorectal-cancer-in-the-norwegian-women-and-cancer-cohort
#8
Lene A Åsli, Anja Olsen, Tonje Braaten, Eiliv Lund, Guri Skeie
Potatoes are the fourth most plentiful food crop in the world, yet the scientific literature on the health effects of potato consumption is scarce. This study aimed to investigate the association between potato consumption and the risk of colorectal cancer (CRC) among 79,778 women aged 41-70, in the Norwegian Women and Cancer study. Information on diet, lifestyle, and health was collected by questionnaire. CRC cases (n  =  912) were identified through registry linkage. Adjusted Cox proportional hazard models were used to estimate the association between potato consumption and the risk of CRC...
March 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28094567/a-vulnerable-age-for-the-introduction-of-solid-foods-in-pediatric-acute-lymphoblastic-leukemia
#9
Jeremy M Schraw, Michael E Scheurer, Michele R Forman
BACKGROUND: There is little research concerning infant formula or the age at introduction to solid foods and pediatric acute lymphoblastic leukemia (ALL). The purpose of this case-control study was to estimate the association of age at introduction of solids and pediatric ALL. METHODS: 171 ALL cases aged 0-14 years were recruited at Texas Children's Cancer Center and matched on sex, age, and ethnicity to 342 population-based controls. Data were collected on infant feeding and known risk factors for ALL...
January 17, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28094538/the-obesity-paradox-in-colorectal-cancer-surgery-an-analysis-of-korean-healthcare-big-data-2012-2013
#10
Sanghun Lee
Although it is well known that obesity increases the risk of colorectal cancer, several studies have recently suggested that those who are overweight or class-one obese have better outcomes after surgery. However, the impact of obesity on the success of colorectal cancer surgery remains controversial. The medical records of patients diagnosed with colorectal cancer who were treated surgically from 2012 through 2013 were retrospectively analyzed. Data from a total of 36,740 patients were provided by the Healthcare Big Data Hub of the Korean Health Insurance Review & Assessment Service...
January 17, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28045565/the-effect-of-licorice-protein-fractions-on-proliferation-and-apoptosis-of-gastrointestinal-cancer-cell-lines
#11
Soheila Khazraei-Moradian, Mazdak Ganjalikhani-Hakemi, Alireza Andalib, Reza Yazdani, Javad Arasteh, Gholam Ali Kardar
BACKGROUND: Several methods for the treatment of colon cancer have been introduced, but none of them are safe and effective. We planned to evaluate the inhibitory effect of protein extract of licorice root on HT-29 and CT26 cell lines proliferation and apoptosis. METHODS: Protein extract of licorice root was prepared in phosphate-buffered solution, and SDS-PAGE was used to isolate its fractions. HT-29, CT-26, and HEK293 cell lines were treated with various concentrations of the fractions and full extract of licorice...
January 3, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28045557/metabolic-syndrome-and-mammographic-density-in-premenopausal-chilean-women
#12
Angela Martínez-Arroyo, Hortensia Moreno-Macías, Ana Pereira Scalabrino, Maria Luisa Garmendia
BACKGROUND: Metabolic syndrome (MetS) has been previously associated with an increased risk of breast cancer in postmenopausal women. Mammographic density (MD) is a marker of breast cancer risk. There is little evidence of an association between MetS and MD in premenopausal women. METHODS: Through a cross-sectional study, we evaluated 364 premenopausal Chilean women in which we measured anthropometric, blood pressure, and metabolic markers. MetS and its components were defined according to the National Cholesterol Education Program Adult Treatment Plan III criteria...
January 3, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28045549/curcumin-and-viscum-album-extract-decrease-proliferation-and-cell-viability-of-soft-tissue-sarcoma-cells-an-in-vitro-analysis-of-eight-cell-lines-using-real-time-monitoring-and-colorimetric-assays
#13
K Harati, B Behr, A Daigeler, T Hirsch, F Jacobsen, M Renner, A Harati, C Wallner, M Lehnhardt, M Becerikli
BACKGROUND: The cytostatic effects of the polyphenol curcumin and Viscum album extract (VAE) were assessed in soft-tissue sarcoma (STS) cells. METHODS: Eight human STS cell lines were used: fibrosarcoma (HT1080), liposarcoma (SW872, T778, MLS-402), synovial sarcoma (SW982, SYO1, 1273), and malignant fibrous histiocytoma (U2197). Primary human fibroblasts served as control cells. Cell proliferation, viability, and cell index (CI) were analyzed by BrdU assay, MTT assay, and real-time cell analysis (RTCA)...
January 3, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28045548/vitamin-d-reduces-colitis-and-inflammation-associated-colorectal-cancer-in-mice-independent-of-nod2
#14
Ihsan Elimrani, Jamie Koenekoop, Serge Dionne, Valerie Marcil, Edgar Delvin, Emile Levy, Ernest G Seidman
Inflammatory bowel disease (IBD) patients are at increased risk of developing colorectal cancer (CRC). Vitamin D (vD) induces NOD2 gene expression, enhancing immunity, while deficiency impairs intestinal epithelial integrity, increasing inflammation. This study investigated the effect of vD on CRC in colitis, and if preventive benefits are mediated via NOD2. Inflammation-associated CRC was induced by treating C57BL/6J and Nod2(-/-) mice with azoxymethane (AOM) and dextran sodium sulfate (DSS) cycles (×3). vD-deficient mice displayed more severe colitis compared to vD-supplemented mice, with greater weight loss, higher colitis activity index, increased colonic weight/length ratios, and lower survival rates...
January 3, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28287324/the-effect-of-a-home-delivery-meal-service-of-energy-and-protein-rich-meals-on-quality-of-life-in-malnourished-outpatients-suffering-from-lung-cancer-a-randomized-controlled-trial
#15
Eva Leedo, Josephine Gade, Sabrina Granov, Anders Mellemgaard, Tobias Wirenfeldt Klausen, Katrine Rask, Arne Astrup
Undernutrition is prevalent in cancer patients and associated with increased incidence of complications and mortality. We investigated the effects of a home delivery meal service, providing a selection of energy-dense, protein-rich meals, on quality of life (QoL) in malnourished lung cancer patients. Forty lung cancer patients with nutritional risk score ≥3 (NRS-2002) were randomized to control or intervention. The intervention group was offered energy- and protein-rich main meals and snacks, delivered 3 times per week...
April 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28287323/relationship-between-the-comprehensive-nutritional-index-and-the-eortc-qlq-h-n35-in-nasopharyngeal-carcinoma-patients-treated-with-intensity-modulated-radiation-therapy
#16
Yan He, Liping Chen, Linmin Chen, Wen Hu, Cong Wang, Linquan Tang, Haiqiang Mai, Jianmei Li, Liping Wu, Yuying Fan
This study aimed to explore the relationship between the comprehensive nutritional index (CNI) and quality of life in nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiation therapy (IMRT). The nutritional index, which includes total lymphocyte count, hemoglobin and albumin levels, body mass index, and usual body weight percentage, was evaluated pre-treatment and post-treatment in patients who underwent IMRT. The quality of life of NPC patients was measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Cancer Module (EORTC QLQ-H&N35) at four time points: pre-treatment, post-treatment, and 3 and 6 mo after IMRT...
April 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28287322/protective-effect-of-pistacia-lentiscus-oil-against-bleomycin-induced-lung-fibrosis-and-oxidative-stress-in-rat
#17
Anouar Abidi, Nadhem Aissani, Hichem Sebai, Raja Serairi, Nadia Kourda, Saloua Ben Khamsa
We aimed in the present study to investigate the protective effect of Pistacia lentiscus oil against bleomycin-induced lung fibrosis as well as the involvement of oxidative stress in such protection. In this respect, adult male Wistar rats were used and divided into three groups of twenty each: control (NaCl, 0.9%), bleomycin, and bleomycin (4 mg/kg b.w.) + P. lentiscus oil (3 g/kg, b.w.). Animals were pretreated for 30 days before the induction of fibrosis by bleomycin and 1 wk after the induction of fibrosis...
April 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28287321/curcumin-nanotechnologies-and-its-anticancer-activity
#18
Parasuraman Aiya Subramani, Kalpana Panati, Venkata Ramireddy Narala
Cancer is one of the leading causes of death worldwide. Curcumin is a well-established anticancer agent in vitro but its efficacy is yet to be proven in clinical trials. Poor bioavailability of curcumin is the principal reason behind the lack of efficiency of curcumin in clinical trials. Many studies prove that the bioavailability of curcumin can be improved by administering it through nanoparticle drug carriers. This review focuses on the efforts made in the field of nanotechnology to improve the bioavailability of curcumin...
April 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28287320/preoperative-prognostic-nutritional-index-correlates-with-severe-complications-and-poor-survival-in-patients-with-colorectal-cancer-undergoing-curative-laparoscopic-surgery-a-retrospective-study-in-a-single-chinese-institution
#19
Xianglong Cao, Gang Zhao, Tao Yu, Qi An, Hua Yang, Gang Xiao
The prognostic nutritional index (PNI) has been correlated with long-term outcomes in cancer patients. However, the relationship between PNI, the postoperative complications, and long-term outcomes in patients with colorectal cancer (CRC) undergoing curative laparoscopic surgery has not been fully investigated. This retrospective study was conducted in the Beijing Hospital between January 2009 and January 2012. A total of 228 patients diagnosed with primary CRC undergoing curative laparoscopic surgery in the center were analyzed...
April 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28287319/the-effect-of-green-tea-consumption-on-prostate-cancer-risk-and-progression-a-systematic-review
#20
Sabrina Anne Jacob, Tahir Mehmood Khan, Learn-Han Lee
This systematic review aimed to assess the clinical benefits of green tea consumption on the progression and prevention of prostate cancer (PCa). A systematic search was performed across the following databases: PubMed, Excerpta Medica dataBASE, Database of Abstracts of Reviews of Effects, Current Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials. We included studies from database inception to September 2015...
April 2017: Nutrition and Cancer
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