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Journal of Autism and Developmental Disorders

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https://www.readbyqxmd.com/read/28229350/-set-in-stone-or-ray-of-hope-parents-beliefs-about-cause-and-prognosis-after-genomic-testing-of-children-diagnosed-with-asd
#1
Marian Reiff, Eva Bugos, Ellen Giarelli, Barbara A Bernhardt, Nancy B Spinner, Pamela L Sankar, Surabhi Mulchandani
Despite increasing utilization of chromosomal microarray analysis (CMA) for autism spectrum disorders (ASD), limited information exists about how results influence parents' beliefs about etiology and prognosis. We conducted in-depth interviews and surveys with 57 parents of children with ASD who received CMA results categorized as pathogenic, negative or variant of uncertain significance. Parents tended to incorporate their child's CMA results within their existing beliefs about the etiology of ASD, regardless of CMA result...
February 22, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28229349/joint-attention-and-the-social-phenotype-of-school-aged-children-with-asd
#2
Peter Mundy, Stephanie Novotny, Lindsey Swain-Lerro, Nancy McIntyre, Matt Zajic, Tasha Oswald
The validity of joint attention assessment in school-aged children with ASD is unclear (Lord, Jones, Journal of Child Psychology and Psychiatry 53(5):490-509, 2012). This study examined the feasibility and validity of a parent-report measure of joint attention related behaviors in verbal children and adolescents with ASD. Fifty-two children with ASD and 34 controls were assessed with the Childhood Joint Attention Rating Scale (C-JARS). The C-JARS exhibited internally consistency, α = 0.88, and one factor explained 49% of the scale variance...
February 22, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28229348/brief-report-using-ipads-for-self-monitoring-of-students-with-autism
#3
Joy F Xin, Mary E Sheppard, Michelle Brown
This study examined the effect of using an iPad for students with autism spectrum disorder (ASD) on self-monitoring their behaviors in class. Four students with ASD were taught on-task behaviors by watching self-modeled video saved in the application "Choiceworks" on their iPads, and collected data on their own behaviors. A single subject research design with ABAB phases was used. Student behaviors were observed using interval recording and behavioral occurrences were compared across phases. Results showed that the participating students' on-task behaviors (e...
February 22, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28224345/electrophysiological-endophenotypes-and-the-error-related-negativity-ern-in-autism-spectrum-disorder-a-family-study
#4
Ann Clawson, Mikle South, Scott A Baldwin, Michael J Larson
We examined the error-related negativity (ERN) as an endophenotype of ASD by comparing the ERN in families of ASD probands to control families. We hypothesized that ASD probands and families would display reduced-amplitude ERN relative to controls. Participants included 148 individuals within 39 families consisting of a mother, father, sibling, and proband. Robust ANOVAs revealed non-significant differences in ERN amplitude and behavioral performance among ASD probands relative to control youth. In subsequent multiple regression analyses group and kinship (proband, sibling, mother, father) did not significantly predict ΔERN (error minus correct ERN) or behavioral performance...
February 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28224344/brief-report-characteristics-of-preschool-children-with-asd-vary-by-ascertainment
#5
Lori-Ann R Sacrey, Lonnie Zwaigenbaum, Peter Szatmari, Susan Bryson, Stelios Georgiades, Jessica Brian, Isabel M Smith, Tracy Vaillancourt, Nancy Garon, Caroline Roncadin, Mayada Elsabbagh
Prospective studies of infant siblings of children diagnosed with autism spectrum disorder (ASD) provide a unique opportunity to characterize ASD as it unfolds. A critical question that remains unanswered is whether and how these children with ASD resemble other children identified from the community, including those with no family history. The purpose of this study was to compare clinical characteristics of children with ASD identified by each method (n = 86 per group), drawn from two Canadian longitudinal research cohorts...
February 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28220359/mothers-and-children-s-story-telling-a-study-of-dyads-with-typically-developing-children-and-children-with-asd
#6
Tiffany L Hutchins, Chelsea Deraway, Patricia Prelock, Ana O'Neill
The production of specific mental state terms types and functions by caregivers and their TD children and caregivers and their children with ASD were assessed in two contexts: a parent's story-telling task and a child's story-telling task. Caregivers of children with ASD produced less causal talk and proportionally less desire and cognitive talk than did caregivers of TD children. When focusing only on variation in our ASD sample, caregivers' and children's production of different mental state references varied with context and were predicted by different child characteristics (i...
February 20, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28220358/potential-risk-factors-for-the-development-of-self-injurious-behavior-among-infants-at-risk-for-autism-spectrum-disorder
#7
Adele F Dimian, Kelly N Botteron, Stephen R Dager, Jed T Elison, Annette M Estes, John R Pruett, Robert T Schultz, Lonnie Zwaigenbaum, Joseph Piven, Jason J Wolff
Prevalence of self-injurious behavior (SIB) is as high as 50% among children with autism spectrum disorder (ASD). Identification of risk factors for the development of SIB is critical to early intervention and prevention. However, there is little empirical research utilizing a prospective design to identify early risk factors for SIB. The purpose of this study was to evaluate behavioral characteristics predicting SIB at age 2 years among 235 infants at high familial risk for ASD. Logistic regression results indicated that presence of SIB or proto-SIB and lower developmental functioning at age 12 months significantly predicted SIB at 24 months...
February 20, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28220357/are-generalized-anxiety-and-depression-symptoms-associated-with-social-competence-in-children-with-and-without-autism-spectrum-disorder
#8
Krista Haley Smith Johnston, Grace Iarocci
Generalized anxiety and depression symptoms may be associated with poorer social outcomes among children with Autism Spectrum Disorder (ASD) without intellectual disability. The goal of this study was to examine whether generalized anxiety and depression symptoms were associated with social competence after accounting for IQ, age, and gender in typically developing children and in children with ASD. Results indicated that for the TD group, generalized anxiety and depression accounted for 38% of the variance in social competence and for children with ASD, they accounted for 29% of the variance in social competence...
February 20, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28214978/depression-in-parents-of-children-diagnosed-with-autism-spectrum-disorder-a-claims-based-analysis
#9
Austin C Cohrs, Douglas L Leslie
Previous studies showing that Autism Spectrum Disorder (ASD) in children can have secondary effects on the child's parents are limited by small sample sizes and parent self-report. We examined the odds of depression in parents of children with ASD compared to parents of children without ASD using a large national claims database. Mothers (OR 2.95, 95% CI 2.81-3.09) and fathers (OR 2.41, 95% CI 2.25-2.58) of children with ASD were more likely to have a diagnosis of depression than parents of children without ASD...
February 18, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28213839/the-role-of-theory-of-mind-on-social-information-processing-in-children-with-autism-spectrum-disorders-a-mediation-analysis
#10
Monica Mazza, Melania Mariano, Sara Peretti, Francesco Masedu, Maria Chiara Pino, Marco Valenti
Individuals with autism spectrum disorders (ASD) show significant impairments in social skills and theory of mind (ToM). The aim of this study was to evaluate ToM and social information processing abilities in 52 children with ASD compared to 55 typically developing (TD) children. A mediation analysis evaluated whether social information processing abilities can be mediated by ToM competences. In our results, children with autism showed a deficit in social skills and ToM components. The innovative results of our study applying mediation analysis demonstrate that ToM plays a key role in the development of social abilities, and the lack of ToM competences in children with autism impairs their competent social behavior...
February 18, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28213838/brief-report-autism-like-traits-are-associated-with-enhanced-ability-to-disembed-visual-forms
#11
Antoinette Sabatino DiCriscio, Vanessa Troiani
Atypical visual perceptual skills are thought to underlie unusual visual attention in autism spectrum disorders. We assessed whether individual differences in visual processing skills scaled with quantitative traits associated with the broader autism phenotype (BAP). Visual perception was assessed using the Figure-ground subtest of the Test of visual perceptual skills-3rd Edition (TVPS). In a large adult cohort (n = 209), TVPS-Figure Ground scores were positively correlated with autistic-like social features as assessed by the Broader autism phenotype questionnaire...
February 17, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28213837/brief-report-meeting-the-needs-of-medically-hospitalized-adults-with-autism-a-provider-and-patient-toolkit
#12
Jocelyn Carter, Sarabeth Broder-Fingert, Ann Neumeyer, Ann Giauque, Ann Kao, Christiana Iyasere
In an effort to meet the needs of adults with autism spectrum disorder (ASD) while hospitalized, a team of experts and providers from Massachusetts General Hospital (MGH), MGH for Children as well as parents of individuals with ASD was sparked in 2013. This became a multidisciplinary collaborative, the MGH Autism Care Collaborative, to improve adult care for inpatients with ASD. The collaborative was created with three goals in mind: (1) to educate internal medicine adult inpatient providers and staff on the unique needs of adults with ASD when hospitalized; (2) to create ASD specific resources for internal medicine adult inpatient providers; (3) to optimize patient care from admission to discharge among adults with ASD admitted to internal medicine services...
February 17, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28213836/the-psychometric-properties-of-a-new-measure-of-sensory-behaviors-in-autistic-children
#13
Louise Neil, Dido Green, Elizabeth Pellicano
Unusual reactions to sensory input became part of the diagnostic criteria for autism spectrum disorder in the DSM-5. Measures accurately assessing these symptoms are important for clinical decisions. This study examined the reliability and validity of the Sensory Behavior Questionnaire, a parent-report scale designed to assess frequency and impact of sensory behaviors in autistic children. The scale demonstrated excellent internal consistency and concurrent validity, and was a better predictor of autistic symptoms than the Short Sensory Profile within a group of 66 school-age autistic children...
February 17, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28213835/fred-r-volkmar-brian-reichow-and-james-mcpartland-eds-adolescents-and-adults-with-autism-spectrum-disorder-springer-international-publishing-2014-337pp-isbn-978-1-4939-0506-5-59-99-hardcover
#14
https://www.readbyqxmd.com/read/28210827/medical-conditions-and-demographic-service-and-clinical-factors-associated-with-atypical-antipsychotic-medication-use-among-children-with-an-autism-spectrum-disorder
#15
Johanna K Lake, Danica Denton, Yona Lunsky, Amy M Shui, Jeremy Veenstra-VanderWeele, Evdokia Anagnostou
This study aimed to describe rates of antipsychotic medication use and the association between their use and demographics, clinical variables, and the use of behavioral/education services among children with ASD. For children with ASD ages 2-11 (n = 4749) and those 12-17 (n = 401), 5.4 and 17.7% were prescribed at least one atypical antipsychotic medication respectively. In the multivariable model of young children, older age, use of multiple psychotropic medications, prior ASD diagnosis, non-white Hispanic race/ethnicity, and oppositional defiant problems were associated with antipsychotic use...
February 16, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28210826/stranger-fear-and-early-risk-for-social-anxiety-in-preschoolers-with-fragile-x-syndrome-contrasted-to-autism-spectrum-disorder
#16
Jessica F Scherr, Abigail L Hogan, Deborah Hatton, Jane E Roberts
This study investigated behavioral indicators of social fear in preschool boys with fragile X syndrome (FXS) with a low degree of autism spectrum disorder (ASD) symptoms (FXS-Low; n = 29), FXS with elevated ASD symptoms (FXS-High; n = 25), idiopathic ASD (iASD; n = 11), and typical development (TD; n = 36). Gaze avoidance, escape behaviors, and facial fear during a stranger approach were coded. Boys with elevated ASD symptoms displayed more avoidant gaze, looking less at the stranger and parent than those with low ASD symptoms across etiologies...
February 16, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28197750/comprehensive-psychometric-analysis-of-the-eyberg-child-behavior-inventory-in-children-with-autism-spectrum-disorder
#17
Kathryn Jeter, Kimberly Zlomke, Paul Shawler, Maureen Sullivan
Many assessment measures have only been validated for one specific diagnostic population, which is costly and reduces the clinical utility of assessments. The Eyberg Child Behavior Inventory (ECBI) is one popular measure designed to assess disruptive behavior problems in youth. The ECBI has sound psychometric properties in typically developing youth, but the factor structure has never been examined in children with autism spectrum disorder (ASD). Therefore, the current study conducted a comprehensive psychometric analysis of the ECBI in children with ASD...
February 15, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28194554/emotion-perception-mediates-the-predictive-relationship-between-verbal-ability-and-functional-outcome-in-high-functioning-adults-with-autism-spectrum-disorder
#18
Sadao Otsuka, Shota Uono, Sayaka Yoshimura, Shuo Zhao, Motomi Toichi
The aim of this study was to identify specific cognitive abilities that predict functional outcome in high-functioning adults with autism spectrum disorder (ASD), and to clarify the contribution of those abilities and their relationships. In total, 41 adults with ASD performed cognitive tasks in a broad range of neuro- and social cognitive domains, and information concerning functional outcomes was obtained. Regression analyses revealed that emotion perception and verbal generativity predicted adaptive functioning directly, and the former mediated between the other two...
February 13, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28188464/brief-report-examination-of-correlates-of-adaptive-behavior-in-children-with-hfasd-using-the-basc-2-parent-rating-scale
#19
Christin A McDonald, James P Donnelly, Jonathan D Rodgers, Marcus L Thomeer, Christopher Lopata, Allyson K Jordan
This study extended the research on correlates of adaptive functioning of high-functioning children with autism spectrum disorder (HFASD) using the Behavior Assessment System for Children-Second Edition (BASC-2). Specifically, this study investigated the relationships between adaptive behavior and age, IQ, and ASD symptomology, in a well-characterized sample of 119 children with HFASD, ages 6-11 years. Results revealed age and IQ were not significantly correlated with adaptive ability. However, total autism symptoms [measured by the Autism Diagnostic Interview-Revised (ADI-R)], as well as ASD-social symptoms were negatively correlated with adaptive ability...
February 10, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28185044/a-predictive-coding-account-of-psychotic-symptoms-in-autism-spectrum-disorder
#20
Gerrit I van Schalkwyk, Fred R Volkmar, Philip R Corlett
The co-occurrence of psychotic and autism spectrum disorder (ASD) symptoms represents an important clinical challenge. Here we consider this problem in the context of a computational psychiatry approach that has been applied to both conditions-predictive coding. Some symptoms of schizophrenia have been explained in terms of a failure of top-down predictions or an enhanced weighting of bottom-up prediction errors. Likewise, autism has been explained in terms of similar perturbations. We suggest that this theoretical overlap may explain overlapping symptomatology...
February 10, 2017: Journal of Autism and Developmental Disorders
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