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International Ophthalmology

M Fatih Aşula, I Umut Onur, F Ulviye Yigit
PURPOSE: Fumagillin has been previously used to treat corneal microsporidial keratitis and also identified as an angiogenesis inhibitor. This study aimed to evaluate efficacy of fumagillin bicyclohexylamine on the rat model of corneal neovascularization induced by silver nitrate cauterization. METHODS: Twenty-four Albino Wistar rats (n = 24) were divided into three groups. Following silver nitrate-induced corneal injury, eyes in Group 1 received one drop of 5 mg/mL topical fumagillin bicyclohexylamine four times daily for 10 days...
July 13, 2018: International Ophthalmology
Chiara De Giacinto, Marco Paoloni, Alberto Armando Perrotta, Marco Rocco Pastore, Rita Piermarocchi, Daniele Tognetto
PURPOSE: To describe the macroscopic characteristics of the subretinal fluid (SRF) and its spilling modality during evacuative puncture in scleral buckling (SB) surgery for rhegmatogenous retinal detachment. METHODS: We retrospective reviewed all the SB surgeries performed over a period of 26 months at the University Eye Clinic of Trieste, Italy. We selected a cohort of 102 patients in which SRF drainage by means of evacuative puncture was performed. A high-definition video was recorded during the whole duration of the procedures, and the macroscopic characteristics of the SRF leakage were assessed...
July 10, 2018: International Ophthalmology
Ibrahim Inan Harbiyeli, Elif Erdem, Seyda Erdogan, Yurdun Kuyucu, Sait Polat, Meltem Yagmur
PURPOSE: To investigate changes in conjunctival tissue of conjunctivochalasis (CCh) patients and to determine the relationship between pathological findings and localization of loose conjunctiva. METHODS: Our study included nineteen eyes of 19 patients who were referred to Cukurova University Ophthalmology Department based on ocular surface symptoms and CCh detected in ocular examination. Amniotic membrane was applied after conjunctival excision as surgical treatment...
July 10, 2018: International Ophthalmology
Ahmet Burak Bilgin, Mehmet Erkan Dogan, Basak Aysun, Kadri Cemil Apaydın
PURPOSE: The aim of this study was to investigate whether intraoperative 360° prophylactic endolaser photocoagulation is necessary for the treatment of uncomplicated retinal detachment. METHODS: This prospective, randomized, comparative and interventional study includes 50 consecutive patients with primary rhegmatogenous retinal detachment (RRD) who were treated by pars plana vitrectomy. The patients were divided into two groups: in Group A endolaser applied to all existing breaks as well as a 360° laser retinopexy, while Group B received endolaser only to the retinal breaks...
July 10, 2018: International Ophthalmology
Nesrin Buyuktortop Gokcinar, Erhan Yumusak, Nurgul Ornek, Serap Yorubulut, Zafer Onaran
PURPOSE: To compare the repeatability and agreement of central corneal thickness (CCT) measurements by spectral-domain optical coherence tomography (OCT), corneal topography (CT) with a combined Scheimpflug-Placido system, optical biometry (OB), specular microscopy (SM), and ultrasound pachymetry (UP). METHODS: A single observer measured CCT twice in 150 eyes of 150 subjects with each of five devices: Nidek RS-3000 Advance OCT, CSO Sirius combined Scheimpflug-Placido disc system CT, Nidek AL-Scan partial coherence interferometry-based OB, Tomey EM-3000 SM, and Reichert iPac ultrasonic pachymeter...
July 9, 2018: International Ophthalmology
Farahnoosh Doustdar, Fatemeh Karimi, Zohreh Abedinyfar, Fahimeh Asadi Amoli, Hossein Goudarzi
BACKGROUND: Pseudomonas is the most common cause of microbial keratitis especially in people who use contact lens. The virulence of Pseudomonas aeruginosa in different eye infections is associated with different virulence factors . METHODS: In this study, 54 P. aeruginosa isolates including 39 isolates from keratitis and 15 isolates from conjunctivitis were evaluated for their ability to form biofilm, production of protease, elastase, alkaline protease and their antibiotic-resistant patterns...
July 7, 2018: International Ophthalmology
Mohammed A Abu-Ameerh, Hanan D Jafar, Maram H Hasan, Muawyah D Al Bdour, Mohammed Msallam, Osama H Ababneh, Dana M Alhattab, Ban Al-Kurdi, Abdelhalim A Awidi, Abdalla S Awidi
PURPOSE: To study the use of autologous platelet lysate prepared in a standardized method for the healing of persistent corneal epithelial defects (PED). STUDY DESIGN: Clinical and experimental investigation. METHODS: In this prospective pilot study ( identifier NCT02979912), ten patients with a PED duration of a minimum 14 days were included. Autologous platelet lysate was prepared in a standardized methodology. Repeated freeze-thaw cycles were used to lyse the platelets...
July 5, 2018: International Ophthalmology
Mohammad Ali Shahab, Tahreem Aman Mir, Sidra Zafar
INTRODUCTION: Uveitis encompasses a wide variety of sight-threatening diseases characterized by intraocular inflammation. It is often classified as infectious and non-infectious uveitis. Unlike infectious uveitis, a distinct infectious agent cannot be identified in non-infectious uveitis and disease origin is usually autoimmune, drug related, or idiopathic. THE ISSUE AT HAND: Non-infectious uveitis can often have a relapsing-remitting course, making it difficult to treat, and poses a significant challenge to ophthalmologists...
June 30, 2018: International Ophthalmology
Lukas Kofler, Sabine Kathrein-Schneider, Katrin Schweinzer, Heinz Kofler
INTRODUCTION: Causes of macular edema are multifactorial, but inflammation, vascular factors and mechanical traction are of major importance. Therapeutic options of macular edema depend on the underlying cause. Intravitreal administration of inhibitors of vascular endothelial growth factor leads to inhibition of retinal neovascularization and subsequent edema. OBJECTIVE: Fumaric acid esters are successfully used in dermatology for years according to their antiangiogenic and anti-inflammatory effects...
June 29, 2018: International Ophthalmology
K Gillmann, A El Ameen, R Massy, F Fabro, A Gasc, C P Herbort
PURPOSE: To assess posterior inflammation using a fluorescein (FA)/indocyanine-green angiography (ICGA) scoring system, and compare them to the presently recommended outcome measure, the standardization of uveitis nomenclature vitreous haze score (SUN-VH) in stromal choroiditis. METHODS: This was a retrospective study on patients with a diagnosis of ocular sarcoidosis(OS), ocular tuberculosis(OT), Birdshot retinochoroiditis(BRC) and Vogt-Koyanagi-Harada disease(VKH) seen in the Centre for Ophthalmic Specialized Care, Lausanne, Switzerland...
June 26, 2018: International Ophthalmology
Erdem Eriş, Irfan Perente, Esra Vural, Aslı Vural, Zeynep Seymen, Ali Rıza Cenk Celebi, Gurkan Erdogan, Abdullah Ozkaya, Ozgur Artunay
PURPOSE: To compare sub-tenon steroid plus anti-VEGF injection with anti-VEGF injection solely in the treatment of resistant diabetic macular edema (DME). METHOD: Patients who exhibited insufficient anatomic [over 350 μm central macular thickness (CMT)] and less than 3 lines of visual gain at least six anti-VEGF injections, were randomly divided into two groups. In group I, the anti-VEGF injection was performed 10 days after the sub-tenon steroid injection [Triamcinolone acetonide (Sinakort-A® )]...
June 26, 2018: International Ophthalmology
Vytautas Jasinskas, Renata Vaiciuliene, Aiste Varoniukaite, Martynas Speckauskas
PURPOSE: To report a series of cases and microsurgical management of rarely occurring uveitis-glaucoma-hyphema (UGH) syndrome in patients with single-piece acrylic intraocular lens (IOL) placed in the capsular bag. METHODS: It was a series of patients with UGH syndrome induced by posterior chamber IOL/capsular bag complex instability (pseudophakodonesis), who underwent IOL fixation to the iris. Visual acuity, intraocular pressure, number of glaucoma medications and IOL status (position) were recorded by the same protocol before and 6 months after the surgical treatment...
June 26, 2018: International Ophthalmology
Pranita Sahay, Divya Agarwal, Prafulla K Maharana, Jeewan S Titiyal
PURPOSE: To report the intra-familial phenotypic variation of granular corneal dystrophy (GCD) across different age groups. METHOD: Two cases of GCD belonging to the same family (mother and daughter) were assessed and clinical findings were noted. RESULT: An 18-year-old female with complaint of glare, on examination showed brownish granules involving bowman's layer and superficial corneal stroma suggesting a diagnosis of Bowman layer dystrophy...
June 25, 2018: International Ophthalmology
Hazem A Elbedewy, Tamer E Wasfy, Shaimaa S Soliman, Moataz M Sabry, Amr M Awara, Sharif Y El Emam, Heba M Shafik, Mostafa R Alam
PURPOSE: To study the prevalence of keratoconus (KC) and the topographical characteristics of the affected corneas in patients with refractive errors who were seeking refractive surgery in the Egyptian delta. METHODS: A retrospective study covering four and half years (Jan 2012-June 2016) where the topographical data of 8124 participants were obtained from the records of a refractive center in the Nile delta region, Egypt. The diagnosis of KC was based on the Holladay criteria in one or both eyes, using the Pentacam scans, whereas grading of KC was based on the Amsler-Krumeich classification...
June 25, 2018: International Ophthalmology
Talal Alabduljalil, Carol A Westall, Arun Reginald, Sina Farsiu, Stephanie J Chiu, Alec Arshavsky, Cynthia A Toth, Wai-Ching Lam
PURPOSE: To demonstrate the anatomical development of the human macula using handheld spectral domain optical coherence tomography (SD-OCT) during the first 5 years of life. METHODS: This study is a cross-sectional, observational case series. Thirty-five normal eyes of 35 full-term/late preterm infants and children under 5 years of age were included. Handheld SD-OCT was used to image the macula of each eye. The data were analyzed using the Duke OCT Retinal Analysis Program v17 software...
June 23, 2018: International Ophthalmology
Brynn N Wajda, Ronald Mancini, Bret Evers, R Nick Hogan
PURPOSE: To describe features of atypical pleomorphic adenoma, a rare clinical entity, particularly when found in ectopic periocular lacrimal gland tissue. METHODS: Case report of biopsy-confirmed periocular atypical pleomorphic adenoma. RESULTS: A 35-year-old female presented with a unique orbital lesion found to be ectopic lacrimal gland demonstrating atypical pleomorphic adenoma on formal histopathologic review. Pleomorphic adenoma is pathologically characterized as an epithelial lesion intermixed with mesenchymal elements...
June 23, 2018: International Ophthalmology
Orkut Guclu, Hande Guclu, Serhat Huseyin, Selcuk Korkmaz, Volkan Yuksel, Suat Canbaz, Vuslat Pelitli Gurlu
PURPOSE: To examine changes in retinal ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (RNFL) thicknesses by optical coherence tomography (OCT) in contralateral and ipsilatateral eyes of carotid artery stenosis (CAS) patients before and after carotid endarterectomy (CEA). METHODS: Forty-two consecutive patients diagnosed with CAS (70-99% stenosis rate) who underwent CEA were included in this prospective cross-sectional study. The indication for CEA was based on the Asymptomatic Carotid Atherosclerosis Study...
June 23, 2018: International Ophthalmology
Ali Asghar Sarchahi, Mehdi Eskandari
PURPOSE: To measure IOP in animals, it is often necessary to use topical anesthetics. The use of these drugs may cause changes in IOP and interfere with the final results. To address this issue, the effects of four local anesthetics (tetracaine, proparacaine, lidocaine, and bupivacaine) on IOP were investigated in ten adult dogs. METHODS: One drop of tetracaine was instilled in the right eye of half of the dogs and in the left eye of the other dogs; normal saline was instilled in the fellow eyes...
June 23, 2018: International Ophthalmology
Zhaotian Zhang, Shaochong Zhang
PURPOSE: To introduce novel and easy techniques for 27-gauge silicone oil (SO) infusion and removal. METHODS: Consecutive patients treated with 27-gauge pars plana vitrectomy (PPV) plus SO infusion (Infusion Group) and scheduled to have SO removal (Removal Group) were prospectively included, respectively. Patients in Infusion Group underwent 27-gauge PPV plus SO infusion. SO infusion was performed with a 24-gauge intravenous catheter connected with the SO syringe...
June 22, 2018: International Ophthalmology
Xiao-Cui Liu, Mao-Nian Zhang, Bing Chen, Ying Li, Hou-Bin Huang
PURPOSE: We aimed to analyze the clinical characteristics of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome. Furthermore, we aimed to correlate the number and location of retinal aneurysms with the size of retinal non-perfusion area and neovascularization. METHODS: Six patients with IRVAN syndrome (1 male and 5 females, age 5-38 years) were enrolled in this study. Fundus fluorescein angiography (FFA) was used to determine the total number of retinal aneurysms, number of aneurysms within the first branch of the retinal artery, minimum distance between the non-perfusion margin and the optic disc, and the number of retinal aneurysms in each quadrant, as well as the type of neovascularization...
June 22, 2018: International Ophthalmology
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