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Journal of Ethnopharmacology

Jung Jae-Young, Hyejin Joo, Jinhyun Bae, Yumi-Bang, Beom-Joon Lee, Jae-Heung Cho, Jae-Woo Park, Kyungjin Lee, Youngmin Bu
ETHNOPHARMACOLOGICAL RELEVANCE: Dangguisusan (DGSS) is a widely used prescription for the treatment of traumatic injury in Korean medicine. AIM OF THE STUDY: To demonstrate the effects of DGSS on a mouse model of traumatic brain injury (TBI) for providing scientific evidence in clinical use. MATERIALS AND METHODS: TBI was induced in a mouse model using the controlled cortical impact method. Water extract of DGSS (50, 150, and 450mg/kg) was administered twice a day for 8 d...
July 13, 2018: Journal of Ethnopharmacology
Alamgeer, C Auger, P Chabert, C Lugnier, M N Mushtaq, V B Schini-Kerth
ETHNOPHARMACOLOGICAL RELEVANCE: Thymus linearis, Benth indigenous to Pakistan has been traditionally used for the treatment of various diseases including hypertension. AIM OF THE STUDY: Present study aims to investigate vasorelaxant effect of Thymus linearis and its underlying vasorelaxation mechanisms in porcine coronary artery rings. MATERIALS AND METHODS: Aqueous-methanolic extract of aerial parts of Thymus linearis was prepared by maceration process and then bio-guided fractionation was carried out using different solvents...
July 13, 2018: Journal of Ethnopharmacology
Laddawan Lalert, Hathairat Kruevaisayawan, Patcharada Amatyakul, Kornkanok Ingkaninan, Onrawee Khongsombat
ETHNOPHARMACOLOGICAL RELEVANCE: Asparagus racemosus (AR) is well known as an Ayurvedic rasayana which used traditionally by Ayurvedic practitioners for nervous disorders and prevent aging. In our previous study it was found that ethanol AR root extract can improve learning and memory impairment, induced by an ovariectomy, but the extract's mechanisms as a neuroprotective property are still unknown. AIM OF THE STUDY: This study aimed to examine the effects and mechanisms of ethanol AR root extract on the alteration of brain-derived neurotrophic factor (BDNF) and estrogen receptor (ER) subtypes in ovariectomized (OVX) rats...
July 12, 2018: Journal of Ethnopharmacology
Nathalia Denise de Moura Sperotto, Luiza Steffens, Rodrigo Moisés Veríssimo, Jeferson Gustavo Henn, Valéria Flores Péres, Priscila Vianna, José Artur Bogo Chies, Adriana Roehe, Jenifer Saffi, Dinara Jaqueline Moura
ETHNOPHARMACOLOGICAL RELEVANCE: Plantago australis is a popular plant found to be widely spread in Latin America. In folk medicine, the seeds and leaves are used mainly for anti-inflammatory, wound healing, among others. The verbascoside, a phenolic glycoside, is an active chemical component described in this species of plant, which has antioxidant, anti-inflammatory and healing effects. PURPOSE: The aim of the present study was to evaluate whether P. australis hydroethanolic extract (PAHE) standardized in verbascoside could promote wound healing associated with anti-inflammatory action within both in vitro and in vivo models...
July 12, 2018: Journal of Ethnopharmacology
Xiaoyan Gao, Lingling Qin, Zhixin Zhang, Huizhen Zhao, Wenjuan Zhou, Ziye Xie, Honghong Yu, Zhenghai Huang
ETHNOPHARMACOLOGICAL RELEVANCE: Qingkailing injection (QKLI) is prepared from eight traditional Chinese medicinal materials or their extracts, which is widely used in clinical practice to treat the upper respiratory inflammation, pneumonia, high fever and viral encephalitis, nonetheless, suffering from serious anaphylaxis. AIM OF STUDY: This study aims to develop an integrative metabolomics approach for deciphering the biochemical basis of QKLI induced anaphylaxis (QKLI-IA)...
July 12, 2018: Journal of Ethnopharmacology
Sujogya Kumar Panda, Raju Das, Pieter Leyssen, Johan Neyts, Walter Luyten
ETHNOPHARMACOLOGICAL RELEVANCE: Knowledge on the use of plants for different ailments by the tribals of the Chirang Reserve Forest (CRF, Northeast India) was used to assess the potential of these plants for treating viral, bacterial and fungal infections. MATERIALS AND METHODS: Fieldwork in the CRF documented the use of plants for the treatment of various human ailments. The ethnobotanical data were analyzed using different quantitative indices viz. Informant Consensus Factor (ICF), Relative Frequency Citation (RFC), Fidelity Level (FL), Relative Popularity Level (RPL) and Rank Order Priority (ROP)...
July 10, 2018: Journal of Ethnopharmacology
Ufuk Cakir, Cuneyt Tayman, Utku Serkant, Halil Ibrahim Yakut, Esra Cakir, Ufuk Ates, Ismail Koyuncu, Eyyup Karaogul
ETHNOPHARMACOLOGICAL RELEVANCE: Necrotizing enterocolitis (NEC) is the most important gastrointestinal emergency affecting especially preterm infants and causes severe morbidities and mortality. However, there is no cure. Oxidant stress, inflammation, apoptosis, as well as prematurity are believed to responsible in the pathogenesis of the disease. Ginger and its compounds have anti-inflammatory, antimicrobial, anti-oxidant properties and immunomodulatory, cytoprotective/regenerative actions...
July 10, 2018: Journal of Ethnopharmacology
Gonzalo R Lara-Issasi, Nitzine E Ocampo, Lia Hoz-Rodríguez, Rodrigo Correa-Prado, Alberto Cedillo-Cruz, Higinio Arzate, Maria I Aguilar
ETHNOPHARMACOLOGICAL RELEVANCE: The medicinal plant Sedum oxypetalum Kunth (Crassulaceae), locally known as Jiote or in general Siempreviva (always alive) has been traditionally used by people of the Mexican community of Tenango del Valle as a home remedy to treat periodontal diseases, inducing teeth strengthening. Consequently, the aim of this work was to investigate its capacity directed to mineralized tissues regeneration. MATERIALS AND METHODS: The aerial parts of the plant were processed and its aqueous extract (AE) was chemically characterized...
July 7, 2018: Journal of Ethnopharmacology
Qiang Zhang, Xiao-Fang Hu, Man-Man Xin, Hong-Bing Liu, Li-Juan Sun, Susan L Morris-Natschke, Yong Chen, Kuo-Hsiung Lee
ETHNOPHARMACOLOGICAL RELEVANCE: The edible plant Physalis alkekengi (PA) is used in traditional medicine to treat diabetes. However, the anti-diabetic effects and constituents of the fruit and aerial parts of this plant have not been studied extensively. AIM OF THE STUDY: The purpose of this study was to investigate the antidiabetic potential of Physalis alkekengi and identify its chemical constituents. MATERIALS AND METHODS: In the present study, the in vitro glucose uptake capacity was tested using the 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) assay in HepG2 cells...
July 5, 2018: Journal of Ethnopharmacology
Xinyao Yang, Xiaoli Gao, Bingzhao Du, Feng Zhao, Xiao Feng, Hexinge Zhang, Zhixiang Zhu, Jianyong Xing, Zhengzhou Han, Pengfei Tu, Xingyun Chai
ETHNOPHARMACOLOGICAL RELEVANCE: Ilex asprella (Hook. et Arn.) Champ. ex Benth. (IA) is a representative medicinal plant from the South of the Five Ridges of China. Its roots (RIA) and stems (SIA) have been traditionally used for the inflammation-related diseases, such as acute and chronic pharyngitis, cough, and sore throats. AIM OF THE STUDY: To evaluate the in vivo anti-inflammatory effects of IA extracts to provide evidence for its traditional use and to enhance the knowledge of the medicinal properties of IA...
July 4, 2018: Journal of Ethnopharmacology
Sandra Morgado, Manuel Morgado, Ana I Plácido, Fátima Roque, Ana Paula Duarte
ETHNOPHARMACOLOGICAL RELEVANCE: Arbutus unedo L., the strawberry tree (Ericaceae family) is of increasing interest because of its common traditional, industrial, chemical and pharmaceutical uses. The plant is a typical evergreen plant of the Mediterranean basin, as well as of other regions with hot summers and mild rainy winters. This review covers the studies relevant to Arbutus unedo L. utilization in the current pharmacological therapy. MATERIALS AND METHODS: The available information on traditional uses, phytochemistry and biological activities of Arbutus unedo L...
July 4, 2018: Journal of Ethnopharmacology
Idha Kusumawati, Kresma Oky Kurniawan, Subhan Rullyansyah, Tri Anggono Prijo, Retno Widyowati, Juni Ekowati, Eka Pramyrtha Hestianah, Suprapto Maat, Katsuyoshi Matsunami
ETHNOPHARMACOLOGICAL RELEVANCE: Temu giring, the rhizome of Curcuma heyneana Valeton & Zipj (C. heyneana), is native to tropical regions, especially in Indonesia. It is traditionally used as a skin care, for cosmetic and body freshness, in Javanese and Balinese women, and has many other bioactivities such as antioxidant, anticancer and antiinflammatory. AIM OF THE STUDY: The purpose of this study was to determine the antiaging activity of C. heyneana to prove its traditional use...
July 3, 2018: Journal of Ethnopharmacology
Lianmei Wang, Xiaoshuang Ding, Chunying Li, Yong Zhao, Changan Yu, Yan Yi, Yushi Zhang, Yue Gao, Chen Pan, Suyan Liu, Jiayin Han, Jingzhuo Tian, Jing Liu, Nuo Deng, Guiqin Li, Aihua Liang
ETHNOPHARMACOLOGICAL RELEVANCE: Aristolochia manshuriensis Kom (AMK), belonging to the Aristolochia family, is traditionally used in China to remove heart fire, promote dieresis, restore menstruation, and enhance milk secretion. The active constitutes of AMK are aristolochic acids (AAs, I and II) that are reported to cause serious side effects including nephrotoxicity and carcinogenicity. AIM OF THE STUDY: The tumorigenic role of AMK is far to be understood. We analyzed the toxicity reactions after long-term exposure of AMK in rats...
July 2, 2018: Journal of Ethnopharmacology
Puthanpura Sasidharan Sreeja, Karuppusamy Arunachalam, Domingos Tabajara de Oliveira Martins, Joaquim Corsino da Silva Lima, Sikiru Olaitan Balogun, Eduarda Pavan, Sathyanarayanan Saikumar, Sivaraj Dhivya, Muniyandi Kasipandi, Thangaraj Parimelazhagan
ETHNOPHARMACOLOGICAL RELEVANCE: Sphenodesme involucrata var. paniculata (C. B. Clarke) Munir is native as well as endemic to South India. Its leaves are used in folklore medicine to treat pain and rheumatism. OBJECTIVE: This study was aimed at investigating the chemical characterization, anti-nociceptive and mechanism of action underlying the anti-inflammatory effects of methanol extract of S. involucrata leaves (MESi). METHODS: Phytoconstituents of MESi was analyzed using colorimetric and liquid chromatography-mass spectrometry (LC-MS) methods, and the oral acute toxicity was evaluated in mice up to 2000 mg/kg...
June 27, 2018: Journal of Ethnopharmacology
A B Cunningham, J A Brinckmann, U Schippmann, D Pyakurel
ETHNOPHARMACOLOGICAL RELEVANCE: Swertia chirayita is the most widely traded species in a genus of 150 species, many of which are used in traditional medicine. S. chirayita is used mainly in Ayurvedic and Tibetan systems of medicine and the homoeopathic system of medicine as well as in regional folk medicine. Primarily wild collected, with some cultivation. S. chirayita is traded as a medicinal substance and exported in the forms of dried whole plant or extract of whole plant individually and/or as active ingredients of Ayurvedic medicines...
June 27, 2018: Journal of Ethnopharmacology
Jonghoon Lim, Haerim Lee, Jiwon Ahn, Jeongjun Kim, Joonseong Jang, Yonghyun Park, Birang Jeong, Heejung Yang, Soon Shik Shin, Michung Yoon
ETHNOPHARMACOLOGICAL RELEVANCE: The herbal composition Gyeongshingangjeehwan 18 (GGEx18), composed of Rheum palmatum L. (Polygonaceae), Laminaria japonica Aresch (Laminariaceae), and Ephedra sinica Stapf (Ephedraceae), is used as an antiobesity drug in Korean clinics. The constituents of GGEx18 have traditionally been reported to inhibit obesity and related metabolic diseases such as insulin resistance and dyslipidemia. OBJECTIVE: This study investigated the effects of GGEx18 on nonalcoholic fatty liver disease (NAFLD) in mice fed a high-fat diet (HFD) and the underlying cellular and molecular mechanisms involved...
June 26, 2018: Journal of Ethnopharmacology
Ilhem Rjeibi, Anouar Feriani, Anouar Ben Saad, Sana Ncib, Jazia Sdayria, Najla Hfaiedh, Mohamed Salah Allagui
ETHNOPHARMACOLOGICAL RELEVANCE: Lycium europaeum Linn. is widely used to treat the burning of the skin and recognized as a medicinal plant having various biological activities. AIMS OF THE STUDY: The purpose of the present study is to characterize the polysaccharide from L. europaeum L. leaves (LEP) and to explore its antioxidant, anti-inflammatory and hepato-nephroprotective properties. MATERIALS AND METHODS: The structural and functional characteristics of LEP were investigated using X-ray diffraction techniques (XRD), Scanning Electron Microscopy (SEM), and FT-IR Spectroscopy...
June 26, 2018: Journal of Ethnopharmacology
A B Cunningham, W Ingram, J A Brinckmann, M Nesbitt
ETHNOPHARMACOLOGICAL RELEVANCE: This is the first study of global trade in fruits of the widely used traditional medicine, Helicteres isora L.. It is used in Ayurvedic, Siddha, Unani medical systems and/or local folk traditional medicines in Bangladesh, India and Pakistan. The roots are used in Traditional Chinese Medicines in China and the fruits in jamu products in Indonesia, Malaysia and Thailand. In addition, H. isora fruits are also used in "traditional" medical systems far beyond the natural distribition of this species, for example in Zulu herbal medicine (South Africa) and Kurdish herbal medicines (Iraq) AIMS OF THE STUDY: This study had three aims: (i) to assess the global trade in H...
June 23, 2018: Journal of Ethnopharmacology
Jaume Pellicer, C Haris Saslis-Lagoudakis, Esperança Carrió, Madeleine Ernst, Teresa Garnatje, Olwen M Grace, Airy Gras, Màrius Mumbrú, Joan Vallès, Daniel Vitales, Nina Rønsted
ETHNOPHARMACOLOGICAL RELEVANCE: The discovery of the antimalarial agent artemisinin is considered one of the most significant success stories of ethnopharmacological research in recent times. The isolation of artemisinin was inspired by the use of Artemisia annua in traditional Chinese medicine (TCM) and was awarded a Nobel Prize in 2015. Antimalarial activity has since been demonstrated for a range of other Artemisia species, suggesting that the genus could provide alternative sources of antimalarial treatments...
June 22, 2018: Journal of Ethnopharmacology
J Ferrier, A Saleem, A Carter Ramirez, R Liu, Eric Chen, T Pesek, V Cal, M Balick, J T Arnason
ETHNOPHARMACOLOGICAL RELEVANCE: Because of the recent increase in type 2 diabetes and the need for complementary treatments in remote communities in many parts of the world, we undertook a study of treatments for diabetic symptoms used by traditional Q'eqchi' Maya healers of Belize. We used quantitative ethnobotany to rank culturally important taxa and subsequent pharmacological and phytochemical studies to assess bioactivity. MATERIALS AND METHODS: Antidiabetic plants identified in field interviews with traditional healers were ranked by syndromic importance value (SIV) based on 15 symptoms of diabetes...
June 21, 2018: Journal of Ethnopharmacology
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