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Journal of Ethnopharmacology

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https://www.readbyqxmd.com/read/28336470/bioassay-guided-isolation-of-active-principles-from-nigerian-medicinal-plants-identifies-new-trypanocides-with-low-toxicity-and-no-cross-resistance-to-diamidines-and-arsenicals
#1
Godwin Unekwuojo Ebiloma, John Ogbaji Igoli, Evangelos Katsoulis, Anne-Marie Donachie, Anthonius Eze, Alexander Ian Gray, Harry P de Koning
ETHNOPHARMACOLOGICAL RELEVANCE: Leaves from the plant species studied herein are traditionally used in northern Nigeria against various protozoan infections. However, none of these herbal preparations have been standardized, nor have their toxicity to mammalian cells been investigated. In search of improved and non-toxic active antiprotozoal principles that are not cross-resistant with current anti-parasitics, we here report the results of the in vitro screening of extracts from seven selected medicinal plant species (Centrosema pubescens, Moringa oleifera, Tridax procumbens, Polyalthia longifolia, Newbouldia laevis, Eucalyptus maculate, Jathropha tanjorensis), used traditionally to treat kinetoplastid infections in Nigeria, and the isolation of their bioactive principles...
March 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28336469/a-review-of-the-ethnopharmacology-phytochemistry-and-pharmacology-of-notopterygium-incisum
#2
REVIEW
John Teye Azietaku, Huifen Ma, Xie-An Yu, Jin Li, Mahmood Brobbey Oppong, Jun Cao, Mingrui An, Yan-Xu Chang
ETHNOPHARMACOLOGICAL RELEVANCE: Notopterygium incisum Ting ex H.T. Chang, known in Chinese as 'Qianghuo' is a traditional Chinese medicinal herb with the rhizome and roots associated with meridians of the kidney and urinary bladder. It is pungent, bitter and warm in nature. It has been used over the years to disperse cold, prevent painful obstructions from wind, damp and warm pain. It has also been used with other herbs to treat wind-cold exterior syndrome and wind-cold-damp bi-syndromes and has been known to grow well in regions of high altitude such as Gansu, Tibet etc...
March 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28330724/treatment-effects-and-mechanisms-of-yujin-powder-on-rat-model-of-large-intestine-dampness-heat-syndrome
#3
Wanling Yao, Chaoxue Yang, Yanqiao Wen, Wangdong Zhang, Xiaosong Zhang, Qi Ma, Peng Ji, Yongli Hua, Yanming Wei
ETHNOPHARMACOLOGICAL RELEVANCE: Yujin Powder (YJP), an old prescription, is one of the most classical prescription for treating the large intestine dampness-heat syndrome (LIDHS). However, its potential modern pharmacological mechanisms remain unclear. AIM OF THE STUDY: The present study was designed to explore the essence of LIDHS and treatment mechanisms of the YJP on the LIDHS. METHODS: The rat model of LIDHS was established by such complex factors as high-sugar and high-fat diet, improper diet, high temperature and humidity environment (HTHE), drinking and intraperitoneal injection of Escherichia coli...
March 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28330723/standardization-and-anti-inflammatory-activity-of-aqueous-extract-of-psittacanthus-plagiophyllus-eichl-loranthaceae
#4
Adrielle Nara Serra Bezerra, Laís Tatiele Massing, Ricardo Bezerra de Oliveira, Rosa Helena Veras Mourão
ETHNOPHARMACOLOGICAL IMPORTANCE: The hemiparasitic species Psittacanthus plagiophyllus Eichl. (Loranthaceae), also known as erva de passarinho, is used in folk medicine in the Santarém region in the state of Pará, Brazil, to treat gastritis and a variety of inflammatory disorders. In view of the lack of pharmacological studies on this species in the literature and the fact that it is used constantly by the local population, this study sought to standardize the extract of the leaves of P...
March 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28330725/a-botanical-phytochemical-and-ethnomedicinal-review-of-the-genus-mitragyna-korth-implications-for-products-sold-as-kratom
#5
REVIEW
Paula N Brown, Jensen A Lund, Susan J Murch
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Mitragyna (Rubiacaeae) has been traditionally used in parts of Africa, Asia and Oceania. In recent years, there has been increased interest in species of Mitragyna with the introduction of products to western markets and regulatory uncertainty. AIM OF THE STUDY: This paper reviewed the traditional ethnomedicinal uses of leaves for species belonging to the genus Mitragyna with reference to the botany and known chemistry in order to highlight areas of interest for products currently being sold as kratom...
March 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28330722/the-use-of-chinese-herbal-medicine-as-an-adjuvant-therapy-to-reduce-incidence-of-chronic-hepatitis-in-colon-cancer-patients-a-taiwanese-population-based-cohort-study
#6
Tsai-Hui Lin, Hung-Rong Yen, Jen-Huai Chiang, Mao-Feng Sun, Hen-Hong Chang, Sheng-Teng Huang
ETHNOPHARMACOLOGICAL RELEVANCE: There is a decided lack of in-depth studies to evaluate the effectiveness of Chinese Herbal Medicine (CHM) as an adjuvant therapy on the incidence of chronic hepatitis in patients with colon cancer. AIM OF THE STUDY: The aim of this study is to assess whether CHM treatment decreased the incidence of chronic hepatitisin colon cancer patients who received conventional Western medical treatment. MATERIALS AND METHODS: A Taiwanese nationwide population-based study of colon cancer patients receiving Western medicine treatment in conjunction with CHM treatment, using data provided by the National Health Insurance (NHI) Research Database, was conducted...
March 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28323049/sutherlandia-frutescens-modulates-adrenal-hormone-biosynthesis-displays-anti-mineralocorticoid-and-serga-properties-acting-as-a-dissociated-glucocorticoid
#7
C A Sergeant, D Africander, P Swart, A C Swart
ETHNOPHARMACOLOGICAL RELEVANCE: Sutherlandia frutescens is a traditional African medicinal plant used in the treatment of stress and anxiety, while also exhibiting anti-inflammatory properties. AIM OF STUDY: The study aimed at linking anti-stress and anti-inflammatory properties of S. frutescens to its influence on glucocorticoid biosynthesis and the inflammatory response via steroid receptor interaction. MATERIALS AND METHODS: The influence of S...
March 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28323047/biochemical-and-chemical-characterization-of-cynara-cardunculus-l-extract-and-its-potential-use-as-co-adjuvant-therapy-of-chronic-myeloid-leukemia
#8
Antonio Russo, Mariarita Perri, Erika Cione, Maria Luisa Di Gioia, Monica Nardi, Maria Cristina Caroleo
ETHNOPHARMACOLOGICAL RELEVANCE: Ancient mediterranean diet was characterized by consuming the spontaneous forms of Cynara Cardunculus L. (CCL), commonly called artichoke. Cultivated and/or spontaneous forms of CC studies have demonstrated that methanol extract of CCL flower and/or cynaropicrin showed remarkable anti-proliferative activity in vitro models of leukocyte cancer cell. AIM OF THE STUDY: Chronic myeloid leukemia (CML) is associated with a reciprocal translocation of the long arms of chromosomes 9 and 22 generating the BCR/ABL fusion gene, translated in the p210(BCR/ABL) oncoprotein kinase...
March 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28323051/anticancer-and-anti-angiogenic-activities-of-extract-from-actinidia-eriantha-benth-root
#9
Jian-Guo Wu, Li Ma, Shui-Hua Lin, Yan-Bin Wu, Jun Yi, Bin-Jun Yang, Jin-Zhong Wu, Ka-Hing Wong
ETHNOPHARMACOLOGICAL RELEVANCE: The roots of Actinidia eriantha Benth (AER) are commonly used traditional folk medicine for the treatment of gastric carcinoma, nasopharyngeal carcinoma, and breast carcinoma. Besides, the anti-proliferative and immunomodulatory effects of AER polysaccharides on tumor-bearing mice have been reported previously. AIM OF THE STUDY: This work was carried out to investigate the anticancer and anti-angiogenic activities of AER. MATERIALS AND METHODS: The growth inhibitory effects of ethanol extracts from the leaves (EEL), stems (EES) and roots (EER) of A...
March 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28323050/antiplasmodial-activity-of-mezoneuron-benthamianum-leaves-and-identification-of-its-active-constituents
#10
Olivia Jansen, Alembert T Tchinda, Jean Loua, Virginie Esters, Ewa Cieckiewicz, Allison Ledoux, Paul D Toukam, Luc Angenot, Monique Tits, Aliou M Balde, Michel Frédérich
ETHNOPHARMACOLOGICAL RELEVANCE: Decoctions of the leaves of M. benthamianum Baill. are used by traditional healers in Guinea to treat malaria and this use was validated by a preliminary clinical assay. AIM OF THE STUDY: To evaluate the in vitro antiplasmodial activity and to identify active compounds from extracts of M. benthamianum leaves. MATERIAL AND METHODS: Antiplasmodial activity of extracts, fractions and pure compounds was evaluated in vitro against a chloroquine-sensitive strain of Plasmodium falciparum (3D7) using the measurement of the plasmodial lactate dehydrogenase activity...
March 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28323048/comparison-of-lamiaceae-medicinal-uses-in-eastern-morocco-and-eastern-andalusia-and-in-ibn-al-baytar-s-compendium-of-simple-medicaments-13th-century-ce
#11
Asmae El-Gharbaoui, Guillermo Benítez, M Reyes González-Tejero, Joaquín Molero-Mesa, Abderrahmane Merzouki
ETHNOPHARMACOLOGICAL RELEVANCE: Transmission of traditional knowledge over time and across culturally and historically related territories is an important topic in ethnopharmacology. Here, we contribute to this knowledge by analysing data on medicinal uses in two neighbouring areas of the Western Mediterranean in relation to a historical text that has been scarcely mentioned in historical studies despite its interest. AIM OF THE STUDY: This paper discusses the sharing of popular knowledge on the medicinal uses of plants between eastern Morocco and eastern Andalusia (Spain), focusing on one of the most useful plant families in the Mediterranean area: Lamiaceae...
March 16, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28323046/centaurium-erythraea-methanol-extract-protects-red-blood-cells-from-oxidative-damage-in-streptozotocin-induced-diabetic-rats
#12
Miloš Đorđević, Mirjana Mihailović, Jelena Arambašić Jovanović, Nevena Grdović, Aleksandra Uskoković, Anja Tolić, Marija Sinadinović, Jovana Rajić, Danijela Mišić, Branislav Šiler, Goran Poznanović, Melita Vidaković, Svetlana Dinić
ETHNOPHARMACOLOGICAL RELEVANCE: Centaurium erythraea Rafn (CE) is a traditional medicinal herb in Serbia with antidiabetic, digestive, antipyretic and antiflatulent effects. AIM OF THE STUDY: To investigate the potential protective effects of the methanol extract of the aerial parts of CE against glyco-oxidative stress in red blood cells (RBCs) in rats with experimentally induced diabetes. MATERIAL AND METHODS: Diabetes was induced in Wistar rats by intraperitoneal (i...
March 16, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28315720/the-protective-effect-of-the-active-components-of-erpc-on-diabetic-peripheral-neuropathy-in-rats
#13
Gai-Mei Hao, Yong-Gang Liu, Yan Wu, Wei Xing, Shu-Zhen Guo, Yong Wang, Zheng-Lin Wang, Chun Li, Tian-Tian Lv, Hong-Liang Wang, Tian-Jiao Shi, Wei Wang, Jing Han
ETHNOPHARMACOLOGICAL RELEVANCE: Euonymus alatus, Radix trichosanthis, Panax notoginseng and Coptis chinensis are popular plants used in traditional Chinese medicine to treat diabetes. AIM OF THE STUDY: The aim of the study is to investigate the therapeutic effect of the active components of Euonymus alatus, Radix trichosanthis, Panax notoginseng and Coptis chinensis (cERPC) on diabetic peripheral neuropathy in the rats and explore the underlying mechanism involved...
March 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28315458/cyperus-rotundus-l-extract-suppresses-rankl-induced-osteoclastogenesis-through-nfatc1-c-fos-downregulation-and-prevent-bone-loss-in-ovx-induced-osteoporosis-rat
#14
Chang-Jun Kum, Eun-Young Kim, Jae-Hyun Kim, Bina Lee, Ju-Hee Min, Jun Heo, Jong-Hyun Kim, Mijung Yeom, Youngjoo Sohn, Hyuk-Sang Jung
ETHNOPHARMACOLOGICAL RELEVANCE: Cyperus Rotundus L. (CyR) has been widely used for the treatment of gynecologic disorder. Recent studies have reported that CyR can prevent the formation of cystic follicles and ovarian malfunction. However, the effects of CyR on osteoclastogenesis and postmenopausal osteoporosis remain unknown. AIM OF THE STUDY: This study was aimed to investigate the preventive effects of CyR on RANKL-induced osteoclast formation and ovariectomy (OVX)-induced bone loss...
March 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28315457/anticonvulsant-activity-and-acute-neurotoxic-profile-of-achyranthes-aspera-linn
#15
Dinesh Y Gawande, Dmitry Druzhilovsky, Raghbir Chand Gupta, Vladimir Poroikov, Rajesh Kumar Goel
ETHNOPHARMACOLOGICAL RELEVANCE: Root powder of Achyranthes aspera Linn. (A. aspera) belongs to family Amaranthaceae is used in Indian traditional medicine for the management of epilepsy and its efficacy is widely acclaimed among the different rural communities. AIM OF THE STUDY: The present study was aimed to establish the possible anticonvulsant effect of A. aspera methanolic root extract using acute anticonvulsant models and to evaluate the acute toxicity and neurotoxic potential A...
March 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28315456/mechanisms-underlying-the-diuretic-effect-of-gomphrena-celosioides-mart-amaranthaceae
#16
Paulo Cesar de Paula Vasconcelos, Danilo Ramos Spessotto, Jane Vasconcelos Marinho, Marcos José Salvador, Arquimedes Gasparotto Junior, Candida Aparecida Leite Kassuya
ETHNOPHARMACOLOGICAL RELEVANCE: Gomphrena celosioides (Amaranthaceae) is a native medicinal plant found in Mato Grosso do Sul State that is used for treating urinary tract and kidney stones. This study aimed to evaluate the diuretic effects of ethanolic extract from G. celosioides (EEGC) on acute and extended diuresis to provide a pharmacological basis for its use in traditional medicine. AIM OF THE STUDY: To evaluate the diuretic and natriuretic activity of EEGC and its mechanism of action in an animal model...
March 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28288826/evaluation-of-acute-and-subacute-toxicity-of-hydroethanolic-extract-of-dolichandra-unguis-cati-l-leaves-in-rats
#17
Juliana Calil Brondani, Fernanda Ziegler Reginato, Evelyne da Silva Brum, Marina de Souza Vencato, Cibele Lima Lhamas, Carine Viana Silva, Maria Izabel Ugalde Marques da Rocha, Liliane de Freitas Bauermann, Melânia Palermo Manfron
ETHNOPHARMACOLOGICAL RELEVANCE: Dolichandra unguis-cati L. is a native climbing plant of Brazil, popularly known as "unha de gato". It has been traditionally used mainly as an antipyretic, anti-inflammatory and anti-tumor agent, yet little toxicological information is found in the literature. AIM OF THE STUDY: To identify the chemical composition of the hydroethanolic extract obtained from the leaves of Dolichandra uniguis-cati and to evaluate the acute and subacute toxicity in male and female rats, in order to assess the safety profile of this plant...
March 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28286104/akr1b10-inhibitory-selaginella-tamariscina-extract-and-amentoflavone-decrease-the-growth-of-a549-human-lung-cancer-cells-in-vitro-and-in-vivo
#18
Yu-Jin Jung, Eun Ha Lee, Chang Gun Lee, Ki-Jong Rhee, Woo-Suk Jung, Yongsoo Choi, Cheol-Ho Pan, Kyungsu Kang
ETHNOPHARMACOLOGICAL RELEVANCE: Selaginella tamariscina (P.Beauv.) Spring is a traditional medicinal plant used to treat various human diseases, including cancer, in Asia. The detailed molecular mechanism underlying the anti-cancer effects of this plant and the anti-cancer action of the combinatorial treatment of S. tamariscina and doxorubicin have not yet been investigated. AIM OF THE STUDY: We evaluated the inhibitory activity of S. tamariscina extract (STE) and its major compound, amentoflavone, on human aldo-keto reductase family 1B10 (AKR1B10), which is a detoxification enzyme involved in drug resistance, to evaluate their anti-cancer effects and their potential as adjuvant agents for doxorubicin cancer chemotherapy...
March 9, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28286103/the-vascular-protective-effects-of-anoectochilus-roxburghii-polysaccharose-under-high-glucose-conditions
#19
Zhen-Ling Liu, Jian-Gang Zhang, Qing Liu, Li-Tao Yi, Yu-Meng Li, Ya Li
ETHNOPHARMACOLOGICAL RELEVANCE: Anoectochilus roxburghii has been used as a health food and a herb for treatment diabetes in China for hundreds years. Anoectochilus roxburghii polysaccharose (ARP) is the major active component of the plant. AIM OF THE STUDY: The present study investigated the vascular protection of ARP in vivo and in vitro experiments. MATERIALS AND METHODS: Hypoglycemic activity of ARP was examined in diabetic mice. Moreover, the further vascular protective effects in vitro were investigated in human umbilical vein endothelial cells (HUVECs) stimulated by high glucose (HG, 35mM)...
March 9, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28284793/toxic-pyrrolizidine-alkaloids-in-herbal-medicines-commonly-used-in-ghana
#20
Emmanuel Letsyo, Gerold Jerz, Peter Winterhalter, Till Beuerle
ETHNOPHARMACOLOGICAL RELEVANCE: Herbal medicines have been used for centuries for the management and treatment of various ailments due to the belief that they pose only little or no health risk and side effects, and also, in part, due to their availability, affordability and/or self-supply. However, the increasing information over the recent years on the occurrence of pyrrolizidine alkaloids (PAs) in honey, herbal food and tea products has raised concerns about the safety of herbal medicines with respect to contamination...
March 8, 2017: Journal of Ethnopharmacology
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