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Journal of Ethnopharmacology

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https://www.readbyqxmd.com/read/29792919/seeing-the-light-shifting-from-wild-rhizomes-to-extraction-of-active-ingredients-from-above-ground-parts-of-paris-polyphylla-var-yunnanensis
#1
Xu-Jie Qin, Wei Ni, Chang-Xiang Chen, Hai-Yang Liu
ETHNOPHARMACOLOGICAL RELEVANCE: The dried rhizomes of Paris polyphylla var. yunnanensis are widely used in traditional Chinese medicine (TCM) as hemostatic, antitumor, and antimicrobial agents. More than 70 Chinese patent medicines are based on P. polyphylla var. yunnanensis rhizomes. Steroidal saponins are considered as the main active ingredients of these rhizomes. However, wild populations of P. polyphylla var. yunnanensis are greatly threatened due to the illegal wild harvest and over-utilization of the rhizomes...
May 21, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29787795/anti-allergy-and-anti-tussive-activity-of-clitoria-ternatea-l-in-experimental-animals
#2
Niraj Kumar Singh, Debapriya Garabadu, Priyanka Sharma, Sushant Kumar Shrivastava, Pradeep Mishra
ETHNOPHARMACOLOGICAL RELEVANCE: Clitoria ternatea flower is traditionally used in the treatment of respiratory disorders including bronchitis and is one of the ingredients in different Ayurvedic preparations that are used in respiratory disorders. However, till date there is no scientific report on the anti-asthmatic activity of this flower. AIM OF THE STUDY: Ethanolic extract of Clitoria ternatea flowers (ECT) was evaluated for its anti-allergy and anti-tussive potential in experimental animals...
May 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29783020/immune-modulation-of-a-novel-lipid-soluble-extract-of-pinellia-pedatisecta-schott-in-the-tumor-microenvironment-of-an-hpv-tumor-burdened-mouse-model
#3
Haixia Huang, Mingxing Zhang, Meng Zhang, Jing Peng, Guiling Li, Congjian Xu, Suiqi Gui
ETHNOPHARMACOLOGICAL RELEVANCE: Pinellia pedatisecta Schott extract (PE), a traditional Chinese medicine, has been used to reduce swelling, dry dampness and suppress cervical tumors. AIMS: To evaluate the roles of PE in the regulation of anti-tumor effects and the cellular immune response in the tumor microenvironment. METHODS: The immune microenvironment of HPV+ TC-1 tumors was examined by immunohistochemistry, real-time PCR and flow cytometry...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29783019/total-flavonoid-extract-of-epimedium-herb-increases-the-peak-bone-mass-of-young-rats-involving-enhanced-activation-of-the-ac10-camp-pka-creb-pathway
#4
Hui-Rong Xi, Hui-Ping Ma, Fang-Fang Yang, Yu-Hai Gao, Jian Zhou, Yuan-Yuan Wang, Wen-Yuan Li, Cory J Xian, Ke-Ming Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Epimedium sagittatum brevicornum Maxim. is an important traditional Chinese herb that has long been used to promote bone fracture healing and treat osteoporosis. AIM OF THE STUDY: Achieving peak bone mass by adolescence has now been accepted to be fundamental for preventing osteoporosis in adulthood life. This study investigated the possibility of increasing peak bone mass in young rats using the total flavonoid extract of Epimedium herb (TFE)...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29783018/tumor-inhibitory-effects-of-intravesical-ganoderma-lucidum-instillation-in-the-syngeneic-orthotopic-mb49-c57-bladder-cancer-mice-model
#5
J W M Yuen, D S Y Mak, E S Chan, M D I Gohel, C F Ng
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (GL) has been traditionally used in oriental medicine as superior health tonic, and there are numerous scientific evidences of its antitumorigenic activities. AIM OF THE STUDY: To evaluate the intravesical chemopreventive effects of ethanol extract of GL (GLe) on bladder cancer. MATERIALS AND METHODS: Intravesical therapy is defined as the direct instillation of a liquid drug into bladder through a catheter...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29783017/the-hydro-ethanolic-extract-of-acacia-seyal-mimosaceae-stem-barks-induced-death-in-an-er-negative-breast-cancer-cell-line-by-the-intrinsic-pathway-of-apoptosis-and-inhibited-cell-migration
#6
Stephane Zingue, Thomas Michel, Julia Cisilotto, Alain Brice Tueche, Derek Tantoh Ndinteh, Leônidas João Mello, Dieudonné Njamen, Tânia Beatriz Creczynski-Pasa
BACKGROUND: Despite the significant developments occurring in the treatment of cancer, it still remains the second deadly disease, responsible for 8.2 million deaths every year. Various natural substances have been studied for active molecules of tumor suppression in the past and the tropical flora, by its diversity, continues to provide new antitumor drugs. Acacia seyal is a plant used in Cameroonian traditional system to treat cancer. It exhibited cytotoxic effects towards human breast adenocarcinoma cells...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29783016/systematic-investigation-of-the-erigeron-breviscapus-mechanism-for-treating-cerebrovascular-disease
#7
Jiangmei Wang, Yangyang Chen, Baoshi Liu, Qian Wang, Lulu Zhang, Zhenzhong Wang, Jun Zhou, Wei Xiao, Chunli Zheng, Yonghua Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Cerebrovascular diseases (CBVDs), characterized by striking morbidity and mortality, have become the most common life-threatening diseases. The existing drugs of CBVDs target one or a few of pathogenic factors, the efficacy of which is limited because of the complexity of CBVDs. Traditional Chinese medicine (TCM), featured by multi-component and multi-target endows the great effectiveness in CBVDs treatment. For instance, Erigeron breviscapus (vant.) Hand...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29783015/extracts-of-compound-muniziqi-granule-suppressed-uterus-contraction-and-ameliorated-oxytocin-inducedprimary-dysmenorrhea
#8
Yue Wei, Tingyun Ma, Hanxue Wang, Jianguo Xing, Yuwen Wang, Zhengyi Gu, Dandan Mu, Qiang Yin, Xuemei Cheng, Changhong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Compound Muniziqi granule (CMG) is usually used as a traditional Uighur medicine to treat acne, chloasma, skin inflammation, primary dysmenorrhea (PDM), and menopausal syndrome. However, there are no sufficient data to support the clinic uses of CMG in PDM. AIM OF THE STUDY: This work aims to examine the effect of CMG as a treatment for PDM and reveal its possible therapeutic mechanism. MATERIALS AND METHODS: In vivo and in vitro mouse PDM models were utilized in this study...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29777902/chemical-characterization-and-cerebroprotective-effect-of-methanolic-root-extract-of-colebrookea-oppositifolia-in-rats
#9
Gollapalle Lakshminarayanashastry Viswanatha, Marikunte V Venkataranganna, Nunna Bheema Lingeswara Prasad, Shylaja Hanumanthappa
ETHNOPHARMACOLOGICAL RELEVANCE: Colebrookea oppositifolia Smith is one of the extensively used plants to treat neurological conditions such as epilepsy by the various ethnic communities in sub-Himalayan regions of India such as Bhoxa, Tharu and nomadic Gujjars. AIM OF THE STUDY: This study was conducted to evaluate the cerebroprotective effect of C. oppositifolia methanolic root (MeCO) extract in Wistar rats. MATERIALS AND METHODS: The MeCO was characterized for total phenolic content and later subjected for detailed liquid chromatography-mass spectrometry analysis...
May 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29777901/interrogation-of-ethnomedicinal-plants-for-synthetic-lethality-effects-in-combination-with-deficiency-in-the-dna-repair-endonuclease-rad1-using-a-yeast-cell-based-assay
#10
Hsu Mon Aung, Chananya Huangteerakul, Wittaya Panvongsa, Amornrat N Jensen, Arthit Chairoungdua, Suchada Sukrong, Laran T Jensen
ETHNOPHARMACOLOGICAL RELEVANCE: Plant materials used in this study were selected based on the ethnobotanical literature. Plants have either been utilized by Thai practitioners as alternative treatments for cancer or identified to exhibit anti-cancer properties. AIM OF THE STUDY: To screen ethnomedicinal plants using a yeast cell-based assay for synthetic lethal interactions with cells deleted for RAD1, the yeast homologue of human ERCC4 (XPF) MATERIALS AND METHODS: Ethanolic extracts from thirty-two species of medicinal plants utilized in Thai traditional medicine were screened for synthetic lethal/sick interactions using a yeast cell-based assay...
May 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29777900/material-basis-research-for-huangqi-jianzhong-tang-against-chronic-atrophic-gastritis-rats-through-integration-of-urinary-metabonomics-and-systemsdock
#11
Yuetao Liu, Wenqian Xu, GuoHong Wang, Xuemei Qin
ETHNOPHARMACOLOGICAL RELEVANCE: Huangqi Jianzhong Tang (HQJZ), a celebrated traditional Chinese medicine (TCM), is commonly used for treatment of chronic atrophic gastritis (CAG) in China. AIM OF THE STUDY: We aimed to screen out the material basis of HQJZ against CAG. MATERIALS AND METHODS: CAG rat model was constructed by alternant administrations of ammonia solution and sodium deoxycholate, and the hunger disorder method. Body weight, biochemical indexes and histopathological exam were used to evaluate the efficacy of HQJZ...
May 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29775695/pulsatilla-decoction-inhibits-candida-albicans-proliferation-and-adhesion-in-a-mouse-model-of-vulvovaginal-candidiasis-via-the-dectin-1-signaling-pathway
#12
Lilin Yang, Haiwang Wu, Weiyu Qiu, Longyi Guo, Xin Du, Qingying Yu, Jie Gao, Songping Luo
ETHNOPHARMACOLOGICAL RELEVANCE: Pulsatilla decoction (PD) is a classical prescription in Traditional Chinese Medicine (TCM) and has been reported to have inhibitory effects on Candida albicans proliferation. STUDY AIM: To investigate the therapeutic effects of PD in the treatment of Vulvovaginal candidiasis (VVC) and elucidate the potential mechanism. MATERIALS AND METHODS: Female BALB/c mice (N=90) were randomized to six treatment groups, including the Control group, Model group, three PD groups and Fluconazole group which served as a positive control (20mg/kg weekly)...
May 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29772356/assessment-of-toxicity-and-differential-antimicrobial-activity-of-methanol-extract-of-rhizome-of-simaba-ferruginea-a-st-hil-and-its-isolate-canthin-6-one
#13
Vanessa Fátima Gazoni, Sikiru Olaitan Balogun, Karuppusamy Arunacham, Darley Maria Oliveira, Valdir Cechinel Filho, Samara Rosolem Lima, Edson Moleta Colodel, Ilsamar Mendes Soares, Sérgio Donizeti Ascêncio, Domingos Tabajara de Oliveira Martins
ETHNOPHARMACOLOGICAL RELEVANCE: Simaba ferruginea A. St.-Hil., Simaroubaceae, popularly known as "calunga" is a typical subtropical shrub used in Central Brazil mainly for infection, anti-inflammatory, analgesic and gastric duodenal-ulcers. It presents in its composition the alkaloid canthin-6-one, an alkaloid indole β-carboxylic. AIM: This study aims to investigate the toxicity, antimicrobial activities of methanol extract of Simaba ferruginea (MESf) and canthin-6-one by using different experimental models...
May 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29772355/safety-assessment-of-morus-nigra-l-leaves-acute-and-subacute-oral-toxicity-studies-in-wistar-rats
#14
Kassia Caroline Figueredo, Camille Gaube Guex, Fernanda Ziegler Reginato, Andreia Regina Haas da Silva, Gabriela Buzatti Cassanego, Cibele Lima Lhamas, Aline Augusti Boligon, Gilberti Helena Hübscher Lopes, Liliane de Freitas Bauermann
ETHNOPHARMACOLOGICAL RELEVANCE: Morus nigra L. is a plant native to Asia, and well adapted to the Brazilian climate. It is popularly known as "amoreira preta", and is part of the National List of Plants of Interest to the Brazilian Unified Health System. It is used in folk medicine mainly to soften the effects of menopause, as anti-inflammatory, antidiabetic and antihypertensive. However, information on safe doses and use is still precarious. AIM OF THE STUDY: To identify the chemical composition of the ethanolic extract of Morus nigra L...
May 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29772354/acute-and-subacute-toxicity-and-chemical-constituents-of-the-hydroethanolic-extract-of-verbena-litoralis-kunth
#15
Rachel de Lima, Camille Gaube Guex, Andreia Regina Haas da Silva, Cibele Lima Lhamas, Karen Luise Dos Santos Moreira, Rosana Casoti, Rafaela Castro Dornelles, Maria Izabel Ugalde Marques da Rocha, Marcelo Leite da Veiga, Liliane de Freitas Bauermann, Melânia Palermo Manfron
ETHNOPHARMACOLOGICAL RELEVANCE: Verbena litoralis Kunth is a native species of South America, popularly known as gervãozinho-do-campo ou erva-de-pai-caetano. It is used in gastrointestinal disorders, as detoxifying the organism, antifebrile properties and amidaglitis. AIM OF THE STUDY: To identify the chemical constituents of the hydroethanolic extract obtained from the aerial parts of V. litoralis and to evaluate the acute and sub-acute toxicity in male and female rats...
May 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29758341/effect-of-zembrin-%C3%A2-and-four-of-its-alkaloid-constituents-on-electric-excitability-of-the-rat-hippocampus
#16
Wilfried Dimpfel, Richard Franklin, Nigel Gericke, Leonie Schombert
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (Mesembryanthemaceae), a succulent plant indigenous to South Africa. is consumed in the form of teas, decoctions and tinctures and is sometimes smoked and used as snuff. In recent years, Sceletium has received a great deal of commercial interest for relieving stress in healthy people, and for treating a broad range of psychological, psychiatric and inflammatory conditions. MATERIAL AND METHODS: The whole extract (Zembrin®) was tested ex vivo in the hippocampus slice preparation after one week of daily oral administration of 5 and 10mg/kg...
May 11, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29758340/traditional-mongolian-medicine-eerdun-wurile-improves-stroke-recovery-through-regulation-of-gene-expression-in-rat-brain
#17
Saren Gaowa, Narisi Bao, Man Da, Qiburi Qiburi, Tsogzolmaa Ganbold, Lu Chen, Altanzul Altangerel, Temuqile Temuqile, Huricha Baigude
ETHNOPHARMACOLOGICAL RELEVANCE: Eerdun Wurile (EW) is one of the key Mongolian medicines for treatment of neurological and cardiological disorders. EW is ranked most regularly used Mongolian medicine in clinic. Components of EW which mainly originate from natural products are well defined and are unique to Mongolian medicine. AIM OF THE STUDY: Although the recipe of EW contains known neuroactive chemicals originated from plants, its mechanism of action has never been elucidated at molecular level...
May 11, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29753098/anti-arthritic-activities-of-ethanol-extracts-of-circaea-mollis-siebold-zucc-whole-plant-in-rodents
#18
Yanhong Yu, Qing Zhang, Jiajia Li, Yeli Guan, Jiangeng Huang, Zhiping Wang, Zhen Zhang, Wenrui Zhang, Jing Guo, Jinghua Li, Jiachun Chen, Qun Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Circaea mollis Siebold & Zucc., a genus of Circaea that follows Onagraceae, has been used for centuries as a folk herb in traditional Chinese medicine (TCM) and Hani Ethnopharmacy for the treatment of joint swelling and pain in rheumatoid arthritis. AIM OF THE STUDY: This study was designed to confirm anti-arthritic effects and its underlying mechanism of ethanol extracts of Circaea mollis Siebold & Zucc. (EEC), which may contribute to provide the pharmacological basis in the treatment of rheumatoid disease...
May 9, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29751125/anti-inflammatory-activities-and-potential-mechanisms-of-phenolic-acids-isolated-from-salvia-miltiorrhiza-f-alba-roots-in-thp-1-macrophages
#19
Haimei Liu, Shuli Ma, Hongrui Xia, Hongxiang Lou, Faliang Zhu, Longru Sun
ETHNOPHARMACOLOGICAL RELEVANCE: The roots of Salvia miltiorrhiza f. alba (Lamiaceae) (RSMA) are used as the Danshen, a traditional Chinese medicine, to treat the vascular diseases at local clinics, especially for the remedy of thromboangiitis obliterans (TAO) more than 100 years. Phenolic acids are one of the major effective constituents of RSMA, and some studies have linked phenolic acids with anti-inflammatory functions. AIM OF THE STUDY: The purpose of this research was to isolate phenolic acids from RSMA and investigate their anti-inflammatory effects and potential mechanisms...
May 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29751124/geopharmaceuticals-of-himalayan-sowa-rigpa-medicine-pharmacopoeial-description-geochemical-identification-their-diversity-and-current-utilization-in-bhutan
#20
Karma Yeshi, Phurpa Wangchuk
ETHNOPHARMACOLOGICAL RELEVANCE: Geological materials/minerals have been used in the Himalayan Sowa Rigpa and Bhutanese traditional medicine (BTM) for treating various disorders for thousands of years. AIM OF THE STUDY: Our study reports the chemical identification of various geological materials and their ethno-medicinal uses for the first time. MATERIALS AND METHODS: A five stage process was conducted including: (1) a survey of specialized ancient ethnomedical literatures (Pharmacopoeias and formularies); (2) freely listing the mineral ingredients reported in the ancient Sowa Rigpa medical texts and translating their ethnomedical uses in equivalent terms in English; (3) cross-checking the chemical names and chemical composition of identified minerals with various mineral databases and mineral handbooks; (4) Authentication and standardization of Sowa Rigpa names through open forum discussion with BTM practitioners; (5) further confirmation of the chemical names of identified minerals by consulting experts and pharmacognosist...
May 8, 2018: Journal of Ethnopharmacology
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