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Journal of Ethnopharmacology

Beodeul Yang, Sura Kim, Jung-Hoon Kim, Chiyeon Lim, Hyungwoo Kim, Suin Cho
ETHNOPHARMACOLOGICAL RELEVANCE: The roots and rhizomes of Gentiana scabra Bunge in the family Gentianaceae comprise a major herbal medicine for skin diseases caused by wind-heat or dampness-heat in China, Japan and Korea. This treatment can clear away heat and dry dampness and purge fire from the liver and gallbladder. AIM OF THE STUDY: This study was designed to investigate the therapeutic potential and anti-inflammatory effects of G. scabra, roots and rhizomes...
January 7, 2019: Journal of Ethnopharmacology
Jinqiang Zhu, Qiaofeng Ye, Shixin Xu, Yan-Xu Chang, Xuan Liu, Yan Ma, Yan Zhu, Shengyu Hua
ETHNOPHARMACOLOGICAL RELEVANCE: Shengmai injection (SMI) is a classical traditional Chinese medicine (TCM) officially recorded in Pharmacopoeia of the People's Republic of China (version 2015) and has long been used to treat heart failure in China. However scientific evidence for the anti-oxidative stress potential of SMI used in traditional medicine is lacking. AIM OF STUDY: The present study aimed to evaluate the efficacy of SMI in alleviating H2 O2 ‑induced Oxidative Stress the underlying mechanisms MATERIALS AND METHODS: H2O2-induced oxidative stress model of cardiomyocytes was established with primary cultured neonatal rat cardiomyocytes...
January 4, 2019: Journal of Ethnopharmacology
Karuppusamy Arunachalam, Amilcar Sabino Damazo, Eduarda Pavan, Darley Maria Oliveira, Fabiana de Freitas Figueiredo, Marco Tulio Marra Machado, Balogun Sikiru Olaitan, Ilsamar Mendes Soares, Robson Dos Santos Barbosa, Tarso da Costa Alvim, Sérgio Donizeti Ascêncio, Domingos Tabajara de Oliveira Martins
ETHNOPHARMACOLOGICAL RELEVANCE: Cochlospermum regium (Bixaceae) is a native shrub of Brazil and its xylopodium (infusion/decoction) is being used for the treatment of gastritis, ulcers, arthritis, intestinal infections, gynaecological infections, skin diseases, among others. The aim of the present study was to evaluate the gastroprotective/antiulcer activity and the mechanism of action of hydroethanolic extract of C. regium xylopodium (HECr), using in vitro and in vivo models. Additionally, phytochemical constituents were identified by high-performance liquid chromatography (HPLC)...
January 3, 2019: Journal of Ethnopharmacology
Xie Zhang, Jia-Zhen Wu, Zhi-Xiu Lin, Qiu-Ju Yuan, Yu-Cui Li, Jia-Li Liang, Janis Ya-Xian Zhan, You-Liang Xie, Zi-Ren Su, Yu-Hong Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Chrysanthemum indicum Linne (C. indicum), a healthy food and folk medicine in China for thousands of years, has been reported to exert heat-clearing and detoxifying effects and extensively applied to treat various symptoms such as inflammation diseases, hepatitis and headache. AIM OF THIS STUDY: The purpose of the present study was to investigate the protective effect of the supercritical carbon dioxide fluid extract from flowers and buds of C...
January 2, 2019: Journal of Ethnopharmacology
Auditeau Emilie, Chassagne François, Bourdy Geneviève, Bounlu Mayoura, Jost Jérémy, Luna Jaime, Ratsimbazafy Voa, Preux Pierre-Marie, Boumediene Farid
RELEVANCE: More than 70 million people suffer epilepsy worldwide. Low availability of anti-epileptic drugs, side-effects and drug-resistant epilepsy affect the quality of life of persons with epilepsy in countries with a poorly developed health system. Herbal medicine is frequently used for this neurological condition. OBJECTIVES: The main objective was to provide a detailed analysis of Herbal Medicine used for neurological conditions related with epilepsy in Asia, Africa and Latin America...
January 2, 2019: Journal of Ethnopharmacology
Fernanda Carolina Ribeiro Dias, Ana Luiza Pereira Martins, Fabiana Cristina Silveira Alves de Melo, Marli do Carmo Cupertino, Marcos de Lucca Moreira Gomes, Jerusa Maria de Oliveira, Eduardo Medeiros Damasceno, Janaina Silva, Wagner Campos Otoni, Sérgio Luis Pinto da Matta
ETHNOPHARMACOLOGICAL USAGES: Leaves and roots of Pfaffia glomerata areused as aphrodisiacs, tranquilizers and antirheumatics. Due to the lack of experimental scientific data, studies are necessary to identify its medicinal properties. AIMS: The present study aimed to evaluate the effect of hydroalcoholic root extract of P. glomerata (Brazilian ginseng extract - BGE) on testicular parenchyma, and evaluate possible harmful effects through testicular oxidative stress analysis...
December 31, 2018: Journal of Ethnopharmacology
Hye Jin Park, In Ho Jung, Huiyoung Kwon, Jimin Yu, Eunbi Jo, Haneul Kim, Se Jin Park, Young Choon Lee, Dong Hyun Kim, Jong Hoon Ryu
ETHNOPHARMACOLOGICAL RELEVANCE: The seeds of Zizyphus jujuba var. spinosa (Bunge) Hu ex H.F. Chow (Rhamnaceae) have long been treated as hypnotic agent for sleep disturbances in traditional Chinese and Korean medicine and many previous studies have focused on its effect in central nervous system. AIMS OF STUDY: The present study aimed to provide evidence showing that the ethanol extract of Zizyphus jujuba var. spinosa seeds (EEZS), which may regulate plasmin activity, has the potential to serve as a therapeutic agent for AD...
December 31, 2018: Journal of Ethnopharmacology
Yin-Yin Siew, Hui-Chuing Yew, Soek-Ying Neo, Si-Min Lew, Shun-Wei Lim, Claire Sophie En-Shen Lim, Yi-Cheng Ng, Wei-Guang Seetoh, Azhar Ali, Chay-Hoon Tan, Hwee-Ling Koh
ETHNOPHARMACOLOGICAL RELEVANCE: The extensive biodiversity of plants in Southeast Asia and inadequate research hitherto warrant a continued investigation into medicinal plants. On the basis of a careful review of fresh medicinal plant usage to treat cancer from previous ethnobotanical interviews in Singapore and from the traditional uses of the indigenous plants, fresh leaves of seven locally grown medicinal plant species were evaluated for anti-proliferative activity. AIM OF THE STUDY: To evaluate the anti-proliferative activity of local medicinal plant species Clausena lansium Skeels, Clinacanthus nutans (Burm...
December 29, 2018: Journal of Ethnopharmacology
Guang Yu, Qian Linnan, Juanjuan Yu, Min Tang, Changming Wang, Yuan Zhou, Xiao Geng, Chan Zhu, Yan Yang, Yang Pan, Xu Shen, Zongxiang Tang
ETHNOPHARMACOLOGICAL RELEVANCE: Strychnos nux-vomica L. (Loganiaceae) is grown extensively in South Asian. The dried seed of this plant, nux vomica, has been clinically used in Chinese medicine for relieving rheumatic pain, reducing swelling and treating cancer. Brucine, the second abundant alkaloid constituent of nux vomica, shows excellent clinical therapetutic effect, especially in relieving pain, but mechanism of brucine in relieving pain is still unclear. AIM OF THE STUDY: Explore the analgesic effect of brucine, reveal the molecular mechanism of brucine analgesia...
December 29, 2018: Journal of Ethnopharmacology
Adedoyin Adefisan, Solomon Owumi, Oluwatosin Adaramoye
ETHNOPHARMACOLOGICAL RELEVANCE: Calliandra portoricensis (CP) is a herb widely used in Nigeria for the treatment of breast engorgement. However, the scientific evidence of this use and its mechanisms of action is not clearly understood. AIM OF THE STUDY: We assessed the chemopreventive effects of methanol extract of CP on N-methyl-N-nitrosourea (NMU)-induced mammary gland toxicity in rats. MATERIALS AND METHODS: Fingerprinting of methanol extract of CP by Gas Chromatography-Mass Spectrometry (GC-MS) was done...
December 29, 2018: Journal of Ethnopharmacology
Donatella D'Eliseo, Elisa Pannucci, Roberta Bernini, Margherita Campo, Annalisa Romani, Luca Santi, Francesca Velotti
ETHNOPHARMACOLOGICAL RELEVANCE: Kiwifruit is native to eastern China and many are the references about the consumption of fruits and fruits extracts of the Actinidia plants in Chinese traditional medicine as therapeutic food supplements to prevent and/or counteract numerous disorders including inflammation-related diseases like cancer. AIM OF THE STUDY: Aim of the present work was to obtain a kiwifruit peel extract, rich in polyphenols, and to explore the anti-inflammatory potential by analyzing its capability to target multiple pathways involved in monocyte-mediated inflammatory response...
December 29, 2018: Journal of Ethnopharmacology
Yusha'u Shu'aibu Baraya, Kah Keng Wong, Nik Soriani Yaacob
ETHNOPHARMACOLOGICAL RELEVANCE: Strobilanthes crispus (L.) Blume, locally known in Malaysia as "Pecah kaca" or "Jin batu", has been traditionally used for treatment of various ailments including cancer. We previously demonstrated that a standardized bioactive subfraction of S. crispus, termed as F3, possessed potent anticancer effects in both in vitro and in vivo breast cancer models. AIM OF THE STUDY: To investigate the potential of F3 from S...
December 27, 2018: Journal of Ethnopharmacology
Larissa Spósito, Fernando Bombarda Oda, Júlia Hunger Vieira, Flavio Alexandre Carvalho, Matheus Aparecido Dos Santos Ramos, Rogério Cardoso de Castro, Eduardo José Crevelin, Antônio Eduardo Miller Crotti, André Gonzaga Dos Santos, Patrícia Bento da Silva, Marlus Chorilli, Taís Maria Bauab
ETHNOPHARMACOLOGICAL RELEVANCE: The number of bacterial strains that are resistant to multiple conventional antimicrobial agents is increasing. In this context, natural products have been widely used as a strategy to treat diseases caused by bacteria. Infections by Helicobacter pylori have attracted attention because they are directly related to severe gastric medical conditions. Casearia sylvestris Swartz, popularly known as guaçatonga, is largely employed to treat gastric disorders in Brazilian folk medicine...
December 27, 2018: Journal of Ethnopharmacology
Swati Pundir, Neeraj Mahindroo
ROYLEA CINEREA: (D.Don) Baillon family Lamiaceae is a shrub of the monotypic genus. Aerial parts of the plant are used traditionally in Indian sub-Himalayas and Nepal for the treatment of jaundice, skin diseases, malaria, diabetes, febrifuge and contusions. METHOD: This article reviews botanical description, phytochemistry, ethnomedicinal uses and pharmacological activities of R. cinerea to evaluate if the scientifically evaluated pharmacological profile of the plant can corroborate ethnomedicinal uses...
December 27, 2018: Journal of Ethnopharmacology
Darshan Singh, Suresh Narayanan, Christian P Müller, Marc T Swogger, Nelson Jeng Yeou Chear, Eshal Bin Dzulkapli, Nur Sabrina Mohd Yusoff, Dinesh Sangarran Ramachandram, Francisco León, Christopher R McCurdy, Balasingam Vicknasingam
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Mitragyna speciosa (Korth.) or kratom have been traditionally used in Malaysia and Thailand mainly to enhance work productivity, as a folk remedy for treating common ailments, and as a mood enhancer. AIM OF THE STUDY: This present study sought to investigate kratom use motives among regular kratom users in Malaysia. MATERIALS AND METHODS: A total of 116 regular kratom users were recruited for this cross-sectional survey...
December 27, 2018: Journal of Ethnopharmacology
Peter Kelechi Ajuogu, Osaro O Mgbere, Disere S Bila, James R McFarlane
ETHNOPHARMACOLOGICAL RELEVANCE: Moringa oleifera Lam. (Moringaceae) is an important plant based staple food, known for its nutritional and medicinal value and is usually prescribed by herbal practitioners in Nigeria and in other tropical countries for the treatment of male infertility problems and reproductive diseases in females. Although the aphrodisiac properties and fertility enhancement potential in males have been reported, the underlying mechanisms for the activity remain unclear...
December 26, 2018: Journal of Ethnopharmacology
Lingesh A, David Paul, Naidu Vgm, Satheeshkumar N
ETHNOPHARMACOLOGICAL RELEVANCE: The flowers of Hibiscus rosa sinensis has array of pharmacological actions. They are used in preparation of herbal decoction and teas, which have been used traditionally to reduce body weight gain and for its effect on metabolic syndrome. AIM OF THE STUDY: To investigate the efficacy of major fraction from ethyl acetate extract of the flower at 25 and 50µg (HRF 25 and 50) in 3T3-L1 cells and delineate its possible mechanism of action...
December 26, 2018: Journal of Ethnopharmacology
Diógenes de Queiroz Dias, Débora Lima Sales, Jacqueline Cosmo Andrade, Ana Raquel Pereira da Silva, Saulo Relison Tintino, Cícera Datiane de Morais Oliveira-Tintino, Gyllyandeson de Araújo Delmondes, Maysa de Oliveira Barbosa, Henrique Douglas Melo Coutinho, Felipe Silva Ferreira, Marcos Fábio Gadelha Rocha, Daniela Maria do Amaral Ferraz Navarro, Suyana Karolyne Lino da Rocha, José Galberto Martins da Costa, Romulo Romeu da Nóbrega Alves, Waltécio de Oliveira Almeida
ETHNOPHARMACOLOGICAL RELEVANCE: Northeast Brazilian ethnoveterinary studies associated with the medicinal use of zootherapies have shown that ruminants' body fat such as sheep (Ovis aries), goats (Capra hircus) and cows (Bos taurus) are used in diseases affecting domestic animals. AIM OF THE STUDY: The objective of this study was to evaluate the antibacterial activity of the fixed oils from these ruminants in isolation and in association with antibiotics. RESULTS: Ovis aries (OFOA), Capra hircus (OFCH) and Bos taurus (OFBT) fixed oils were extracted using a Soxhlet apparatus with hexane as the solvent...
December 25, 2018: Journal of Ethnopharmacology
Jing-Ming Chen, Ting-Ting Yang, Tai-Shan Cheng, Ting-Fen Hsiao, Peter Mu-Hsin Chang, Jyh-Yih Leu, Feng-Sheng Wang, Shih-Lan Hsu, Chi-Ying F Huang, Jin-Mei Lai
ETHNOPHARMACOLOGICAL RELEVANCE: Sijunzi decoction is a well-known traditional Chinese medicine (TCM) commonly used for invigorating vital energy and for the enhancement of immunity. Modified Sijunzi decoctions have been extensively used to treat cachexia and improve the quality of life of cancer patients undergoing chemotherapy. AIM OF THE STUDY: This study was aimed to provide comprehensive evidence for the anti-cachectic effect of a modified Sijunzi decoction (Zhen-Qi; ZQ-SJZ) and characterize its anti-cachectic mechanism, especially in cisplatin-induced muscle atrophy...
December 24, 2018: Journal of Ethnopharmacology
Bangjie Li, Junqian Rui, Xuejian Ding, Xinghao Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Banxia Xiexin Decoction (BXD) is a representative prescription to regulate spleen and stomach in "Treatise on Febrile Diseases", which has been proven effective for the clinical treatment of irritable bowel syndrome (IBS) in the past decades. However, the active principles and molecular mechanisms involved in BXD against IBS are unknown yet. AIM OF THE STUDY: To reveal multicomponent synergy mechanism of BXD on irritable bowel syndrome, we analysed important components, drug targets and crucial pathways using a systems pharmacology strategy...
December 24, 2018: Journal of Ethnopharmacology
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