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Journal of Ethnopharmacology

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https://www.readbyqxmd.com/read/30243827/clinical-efficacy-and-safety-of-aidi-injection-plus-paclitaxel-based-chemotherapy-for-advanced-non-small-cell-lung-cancer-a-meta-analysis-of-31-randomized-controlled-trials-following-the-prisma-guidelines
#1
Zheng Xiao, Chengqiong Wang, Minghua Zhou, Shanshan Hu, Yuan Jiang, Xiaorong Huang, Nana Li, Jihong Feng, Fushan Tang, Xiaofan Chen, Jie Ding, Ling Chen, Yuhe Wang, Xiaofei Li
ETHNOPHARMACOLOGICAL RELEVANCE: As an important Chinese herb injection, Aidi injection is composed of the extracts from Astragalus, Eleutherococcus senticosus, Ginseng, and Cantharis. Aidi injection plus paclitaxel-based chemotherapy is often used to in the treatment of non-small cell lung cancer (NSCLC) in China. AIM OF THE STUDY: The objective of this study is to further confirm whether Aidi injection can improve the tumor responses and survivals, and reveal its safety, optimal usage and combination with paclitaxel...
September 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30243826/astragali-radix-and-its-compound-formononetin-ameliorate-diesel-particulate-matter-induced-skin-barrier-disruption-by-regulation-of-keratinocyte-proliferation-and-apoptosis
#2
Ly Thi Huong Nguyen, Uy Thai Nguyen, Yeoun-Hee Kim, Heung-Mook Shin, In-Jun Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Astragali Radix (AR), the root of Astragalus mongholicus Bunge, is widely applied in traditional medicine to promote skin health and tissue regeneration. AIM OF THE STUDY: This study investigated the effects of AR and its active compound, formononetin (FMT), on skin barrier defects in keratinocytes exposed to diesel particulate matter (PM). MATERIALS AND METHODS: HaCaT cells and three-dimensional (3D) human skin reconstructed model were pre-treated with AR (50, 100μg/ml) and FMT (30, 50μM), then treated with PM (200μg/ml)...
September 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30243825/astragali-radix-and-its-main-bioactive-compounds-activate-the-nrf2-mediated-signaling-pathway-to-induce-p-glycoprotein-and-breast-cancer-resistance-protein
#3
Yanmei Lou, Zhenzhen Guo, Yuanfeng Zhu, Guiyu Zhang, Ying Wang, Xiaoxiao Qi, Linlin Lu, Zhongqiu Liu, Jinjun Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Astragali radix (Huang Qi, HQ), a well-known Chinese herbal medicine, is widely coadministered with many other drugs for treating diseases. The potential herb-drug interactions (HDIs) possibly occur during the combination therapy. P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are the crucial targets that mediate the production of HDIs. We previously observed that HQ and its three main bioactive compounds, including Astragaloside IV (AS-IV), calycosin (CS) and formononetin (FMNT), could significantly induce the expression of P-gp and BCRP in HepG2 cells in vitro...
September 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30240786/comparative-comprehension-on-the-anti-rheumatic-chinese-herbal-medicine-siegesbeckiae-herba-combined-computational-predictions-and-experimental-investigations
#4
Qian Ru Zhang, Zhang Feng Zhong, Wei Sang, Wei Xiong, Hong Xun Tao, Guan Ding Zhao, Zhi Xin Li, Anfernee Kai Wing Tse, Yuan Jia Hu, Hua Yu, Yi Tao Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Siegesbeckiae Herba (SH) is a traditional anti-rheumatic herbal medicine in China. The SH-derived product is also the first licensed traditional herbal medicinal product for management of rheumatism-induced joint and muscle pain in United Kingdom. Officially, the authenticated plant origins by the current Chinese Pharmacopeia for SH include Siegesbeckia orientalis L. (SO), S. pubescens Markino (SP) and S. glabrescens Markino (SG). Although the therapeutic effects of the three SH species were very similar in treating rheumatoid arthritis (RA), the difference in chemistry suggested the poteintial biological mechanisms of individual SH species in anti-rheumatism...
September 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30223051/nigella-satival-seed-regulated-enos-vcam-1-and-lox-1-genes-expression-and-improved-vasoreactivity-in-aorta-of-diabetic-rat
#5
Abbasali Abbasnezhad, Saeed Niazmand, Maryam Mahmoudabady, Seyed Abdolrahim Rezaee, Mohmmad Soukhtanloo, Razieh Mosallanejad, Parichehr Hayatdavoudi
ETHNOPHARMACOLOGICAL RELEVANCE: Nigella sativa L. seed has been widely used in traditional medicine for the treatment of diabetes. The major reason for vascular complications in diabetic patients is endothelial dysfunction. However, the impact of N. sativa seed on endothelial dysfunction in diabetes remains unclear. AIM OF THE STUDY: This study was conducted to evaluate the effect of the hydroalcoholic extract of N. sativa seed on eNOS, VCAM-1, and LOX-1 genes expression and the vasoreactivity of aortic rings to acetylcholine (Ach) in streptozotocin (STZ)-induced diabetic rat...
September 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30223050/compatibility-and-its-metabolism-by-intestinal-bacteria-altered-the-transport-of-toxic-diterpenoid-alkaloids-from-processed-aconite-root-lateral-root-of-aconitum-carmichaelii-debx-in-traditional-chinese-formula-si-ni-decoction-across-caco-2-monolayers
#6
Min Zhang, Ying Peng, Mengyue Wang, Beibei Gao, Lijuan Zhao, Xiaobo Li
ETHNOPHARMACOLOGICAL RELEVANCE: In traditional Chinese medicine, processed aconite root (lateral root of Aconitum carmichaelii Debx., Fuzi in Chinese) is used as the principle herb of the Si-Ni decoction (SND) formula due to its cardiotonic effect, while its cardiotoxicity and neurotoxicity caused by diester and monoester diterpenoid alkaloids are reduced by compatibility of dried ginger (Ganjiang in Chinese) and honey-processed liquorice (Zhi-gancao in Chinese) in SND. AIM OF THE STUDY: To investigate the detoxification of processed aconite root by compatibility of SND from the perspective of intestinal absorption with metabolism in intestinal bacteria...
September 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30223049/achyranthes-aspera-linn-alleviates-cerebral-ischemia-reperfusion-induced-neurocognitive-biochemical-morphological-and-histological-alterations-in-wistar-rats
#7
Gollapalle Lakshminarayanashastry Viswanatha, Marikunte V Venkataranganna, Nunna Bheema Lingeswara Prasad, Hanumanthappa Shylaja
ETHNOPHARMACOLOGICAL RELEVANCE: In the traditional system of Indian medicine, the whole plant and roots of Achyranthes aspera L have been extensively used to treat neurological conditions such as epilepsy and stroke by the various ethnic communities of India. AIM OF THE STUDY: The present study was aimed to evaluate the cerebroprotective potential of methanol extract of A. aspera aerial parts (MeAA). MATERIALS AND METHODS: Initially the MeAA was evaluated for total phenolic content and subjected to detailed liquid chromatography-mass spectrometry analysis...
September 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30218813/fabiana-imbricata-ruiz-et-pav-solanaceae-a-review-of-an-important-patagonian-medicinal-plant
#8
REVIEW
Guillermo Schmeda-Hirschmann, Cristina Theoduloz
ETHNOPHARMACOLOGICAL RELEVANCE: Fabiana imbricata (Solanaceae) is a Patagonian medicinal plant with a long tradition of use. The aim of this review is to provide an integrative overview of the traditional uses, chemistry, bioactivity and chemical profiling of the crude drug. MATERIALS AND METHODS: The information was collected from scientific databases searching with the keywords Fabiana imbricata, Fabiana species, Fabiana (Solanaceae) and includes local literature and books...
September 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30218812/an-ethanol-extract-of-the-rhizome-of-atractylodes-chinensis-exerts-anti-gastritis-activities-and-inhibits-akt-nf-%C3%AE%C2%BAb-signaling
#9
Muhammad Jahangir Hossen, Ji-Yao Chou, Su-Mei Li, Xiu-Qiong Fu, Chengle Yin, Hui Guo, Aftab Amin, Gui-Xin Chou, Zhi-Ling Yu
ETHNOPHARMACOLOGICAL RELEVANCE: The rhizome of Atractylodes chinensis (DC.) kodiz (Compositae) has traditionally been used to treat inflammatory disorders such as arthritis and stomach ache, but scanted report has been issued on its anti-inflammatory mechanisms. AIM OF THE STUDY: Here, we investigated the anti-gastritis activities and explored the mechanism of action of an ethanolic extract of the herb (Ac-EE). MATERIALS AND METHODS: Ac-EE was prepared with 95% ethanol...
September 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30218811/effects-of-parkia-biglobosa-aqueous-seed-extract-on-some-biochemical-haematological-and-histopathological-parameters-in-streptozotocin-induced-diabetic-rats
#10
Ubong S Ekperikpe, Omonkhelin J Owolabi, Bolanle I Olapeju
ETHNOPHARMACOLOGICAL RELEVANCE: Parkia biglobosa seeds are used to treat diabetes and complications hence this study. AIM: This study investigated the effects of Parkia biglobosa aqueous seed extract on some biochemical, haematological and histopathological indices in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Wistar rats of either sex (180-300g) were fasted overnight and diabetes mellitus induced using streptozotocin 40mg/kg IP...
September 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30218810/the-immunostimulatory-effects-and-chemical-characteristics-of-heated-honey
#11
Misato Ota, Kan'ichiro Ishiuchi, Xin Xu, Masaaki Minami, Yasutaka Nagachi, Maho Yagi-Utsumi, Yoshiaki Tabuchi, Shao-Qing Cai, Toshiaki Makino
ETHNOPHARMACOLOGICAL RELEVANCE: In traditional Chinese medicine (TCM), honey has been used as an additive in the heat-processing of herbal medicines to enhance their immunostimulatory activities. AIM OF THE STUDY: We investigated the immunostimulatory activity of heated honey in vitro and in vivo. MATERIALS AND METHODS: For the in vitro study, we compared the differences among the inducible effects of honey subjected to various heating conditions on granulocyte colony-stimulating factor (G-CSF) secretion from the cultured enterocytes and investigated the active ingredient...
September 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30218809/bu-yang-huan-wu-decoction-prevents-reperfusion-injury-following-ischemic-stroke-in-rats-via-inhibition-of-hif-1-%C3%AE-vegf-and-promotion-%C3%AE-enac-expression
#12
Zhen-Zhen Chen, Xin Gong, Qi Guo, Hui Zhao, Lei Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Bu Yang Huan Wu Decoction (BYHW) is a famous traditional Chinese medicine (TCM) formula used in China for the treatment of cerebral ischemic stroke. But the protective effects and underlining mechanisms of BYHW remain unclear. AIM OF THE STUDY: This study was designed to investigate the protective effects and underlining signaling mechanisms of BYHW on brain tissues in a rat model of cerebral ischemic reperfusion (I/R) injury. MATERIALS AND METHODS: Liquid chromatography was used to verify the composition of BYHW...
September 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30217790/origanum-majorana-l-extract-exhibit-positive-cooperative-effects-on-the-main-mechanisms-involved-in-acute-infectious-diarrhea
#13
Hanane Makrane, Mohammed Aziz, Hassane Mekhfi, Abderrahim Ziyyat, Abdelkhaleq Legssyer, Ahmed Melhaoui, Mohamed Berrabah, Mohamed Bnouham, Chakib Alem, Ferdinand Kouoh Elombo, Bernard Gressier, Jehan-François Desjeux, Bruno Eto
ETHNOPHARMACOLOGICAL RELEVANCE: Origanum majorana L. (Lamiaceae) is commonly used in Moroccan folk medicine to treat infantile colic, abdominal discomfort and diarrhea. Liquid stools and abdominal discomfort observed in acute infectious diarrhea are the consequences of imbalance between intestinal water secretion and absorption in the lumen, and relaxation of smooth muscle surrounding the intestinal mucosa. AIM OF THE STUDY: The objective of our study was to see if aqueous extract of Origanum majorana L...
September 11, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30217789/antimicrobial-activity-of-elytropappus-rhinocerotis-asteraceae-against-micro-organisms-associated-with-foot-odour-and-skin-ailments
#14
I M Hulley, S F van Vuuren, N J Sadgrove, B-E van Wyk
ETHNOPHARMACOLOGICAL RELEVANCE: The twigs of Elytropappus rhinocerotis are widely used in the Cape region of South Africa to treat foot odour, perspiration and also itchy, chilblained and burning feet. However, no antimicrobial studies have hitherto been published on this popular Cape herbal medicine, which is also used for a wide range of ailments. AIMS OF THE STUDY: To determine the antimicrobial activity of the extracts, essential oil and two major labdane diterpenes isolated from E...
September 11, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30205181/cannabis-sativa-a-comprehensive-ethnopharmacological-review-of-a-medicinal-plant-with-a-long-history
#15
REVIEW
Sara Anna Bonini, Marika Premoli, Simone Tambaro, Amit Kumar, Giuseppina Maccarinelli, Maurizio Memo, Andrea Mastinu
ETHNOPHARMACOLOGICAL RELEVANCE: Cannabis sativa L. (C. sativa) is an annual dioecious plant, which shares its origins with the inception of the first agricultural human societies in Asia. Over the course of time different parts of the plant have been utilized for therapeutic and recreational purposes, for instance, extraction of healing oils from seed, or the use of inflorescences for their psychoactive effects. The key psychoactive constituent in C. sativa is called Δ-9-tetrahydrocannabinol (D9-THC)...
September 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30205180/origanum-majorana-l-extract-exhibit-positive-cooperative-effects-on-the-main-mechanisms-involved-in-acute-infectious-diarrhea
#16
Hanane Makrane, Mohammed Aziz, Hassane Mekhfi, Abderrahim Ziyyat, Abdelkhaleq Legssyer, Ahmed Melhaoui, Mohamed Berrabah, Mohamed Bnouham, Chakib Alem, Ferdinand Kouoh Elombo, Bernard Gressier, Jehan-François Desjeux, Bruno Eto
ETHNOPHARMACOLOGICAL RELEVANCE: Origanum majorana L. (Lamiaceae) is commonly used in Moroccan folk medicine to treat infantile colic, abdominal discomfort and diarrhea. Liquid stools and abdominal discomfort observed in acute infectious diarrhea are the consequences of imbalance between intestinal water secretion and absorption in the lumen, and relaxation of smooth muscle surrounding the intestinal mucosa. AIM OF THE STUDY: The objective of our study was to see if aqueous extract of Origanum majorana L...
September 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30201231/bioactivity-of-acanthus-mollis-contribution-of-benzoxazinoids-and-phenylpropanoids
#17
P Matos, A Figueirinha, A Paranhos, F Nunes, P Cruz, C F G C Geraldes, M T Cruz, M T Batista
ETHNOPHARMACOLOGICAL RELEVANCE: Acanthus mollis is a plant native to the Mediterranean region, traditionally used as diuretic, anti-inflammatory and soothing of the mucous membranes of the digestive and urinary tract and externally as healing of wounds and burns, also demonstrating analgesic and anti-inflammatory activities. However, studies focused on its phytochemical composition as well as scientific proof of Acanthus mollis efficacy are scarce. AIM OF THE STUDY: The proposed work aims to perform a phytochemical characterization and evaluation of the therapeutic potential of Acanthus mollis, based on biological properties that support its traditional uses...
September 7, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30201230/in-vitro-antiplasmodial-activity-and-identification-using-tandem-lc-ms-of-alkaloids-from-aspidosperma-excelsum-a-plant-used-to-treat-malaria-in-amazonia
#18
Myrth Soares do Nascimento, Nayla di Paula Vieira Pina, Andressa Santa Brigida da Silva, Luís Fabio Dos Santos Gomes, Flávio de Vasconcellos, Geraldo Célio Brandão, Maria Fernanda Alves do Nascimento, Alaíde Braga de Oliveira, Wagner Luiz Ramos Barbosa
ETHNOPHARMACOLOGICAL RELEVANCE: Aspidosperma excelsum Benth. (Apocynaceae) is a native tree in the Brazilian Amazonia, where it is traditionally used to treat various diseases, including malaria. AIM OF STUDY: To investigate the chemical constitution of different samples obtained from A. excelsum by chromatographic techniques and to evaluate its antimalarial potential. MATERIALS AND METHODS: The hydroethanolic extract and the alkaloid fractions from trunk bark of A...
September 7, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30201229/root-bark-of-discaria-americana-attenuates-pain-a-pharmacological-evidence-of-interaction-with-opioidergic-system-and-trp-asic-channels
#19
Róli Rodrigues Simões, Scheila Iria Kraus, Roberta Rosso, Alessandra Bridi, Rosana Casoti, Janice Dahmer, Ademir Farias Morel, Adair Roberto Soares Dos Santos, Eliane Maria Zanchet
ETHNOPHARMACOLOGICAL RELEVANCE: Discaria americana (Rhamnaceae) root bark infusion have been used in traditional medicine as antipyretic, tonic, ameliorative of stomach and skin diseases and diabetes. This study was designed to investigate whether the methanolic extract of the root bark of Discaria americana (MEDa) exhibits antinociceptive effects in mice. Furthermore, it was investigated the involvement of the opioidergic system in MEDa mechanism of action as well the interactions with TRP/ASIC channels in its effect...
September 7, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30195569/mucosal-immunomodulatory-evaluation-and-chemical-profile-elucidation-of-a-classical-traditional-chinese-formula-bu-zhong-yi-qi-tang
#20
Liyin Liu, Liufang Hu, Zhihong Yao, Zifei Qin, Mayu Idehara, Yi Dai, Hiroaki Kiyohara, Haruki Yamada, Xinsheng Yao
ETHNOPHARMACOLOGICAL EVIDENCE: With fast development and high pace life in modern society, autoimmune diseases like inflammatory bowel disease had become increasingly common. Bu-Zhong-Yi-Qi-Tang (BZYQT), a famous traditional Chinese medicine prescription (TCMP), has been used for 700 years mainly in Eastern Asia countries for the treatment of gastrointestinal and respiratory disorder, and weakness after serious diseases. These diseases were proved to be closely related to human immune system, among which, mucosal immune system is the largest immune system...
September 6, 2018: Journal of Ethnopharmacology
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