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Journal of Ethnopharmacology

Zhihui Liu, Jianxiu Zhai, Na Han, Jun Yin
ETHNOPHARMACOLOGICAL RELEVANCE: Astilboides tabularis has a long history of usage as the functional food with the effect of adjunctive therapy of diabetic in northeast of China. The present study was undertaken to assess anti-diabetic activity of the aqueous extract of leaves of A. tabularis and provided experimental evidence for the clinical usage of A. tabularis in the treatment of diabetes mellitus. MATERIALS AND METHODS: The aqueous extracts of leaves of A. tabularis (EAT) were orally administered at 300 and 600mg/kg dose to epinephrine-induced and alloxan-induced diabetes mice...
October 14, 2016: Journal of Ethnopharmacology
Juan Bai, Ying Zhu, Ying Dong
ETHNOPHARMACOLOGICAL RELEVANCE: Bitter melon (Momordica charantia L.) is rich in a variety of biologically active ingredients, and has been widely used in traditional Chinese medicine (TCM) to treat various diseases, including type 2 diabetes and obesity. AIM OF THE STUDY: We aimed to investigate how bitter melon powder (BMP) could affect obesity-associated inflammatory responses to ameliorate high-fat diet (HFD)-induced insulin resistance, and investigated whether its anti-inflammatory properties were effected by modulating the gut microbiota...
October 14, 2016: Journal of Ethnopharmacology
Cong Lu, Zhe Shi, Xiuping Sun, Ruile Pan, Shanguang Chen, Yinghui Li, Lina Qu, Lihua Sun, Haixia Dang, Lanlan Bu, Lingling Chen, Xinmin Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Kai Xin San (KXS), a traditional formula of Chinese medicine, has been used to treat dementia. AIM OF THE STUDY: The present study aimed to investigate its ameliorating effects on Aβ1-40-induced cognitive impairment in rats using a series of novel reward-directed instrumental learning tasks, and to determine its possible mechanism of action. MATERIALS AND METHODS: Rats were pretreated with KXS aqueous extract (0...
October 14, 2016: Journal of Ethnopharmacology
Bo Sun, Xubin Wang, Ruili Cao, Qi Zhang, Qiao Liu, Meifeng Xu, Ming Zhang, Xiangbo Du, Fangting Dong, Xianzhong Yan
ETHNOPHARMACOLOGICAL RELEVANCE: Fuzi, the processed lateral root of Aconitum carmichaelii Debeaux, is a traditional Chinese medicine used for its analgesic, antipyretic, anti-rheumatoid arthritis and anti-inflammation effects; however, it is also well known for its toxicity. Gancao, the root of Glycyrrhiza uralensis Fisch., is often used concurrently with Fuzi to alleviate its toxicity. However, the mechanism of detoxication is still not well clear. AIM OF THE STUDY: In this study, the effect of Gancao on the metabolic changes induced by Fuzi was investigated by NMR-based metabonomic approaches...
October 13, 2016: Journal of Ethnopharmacology
Kuo Zhang, Jingyu Yang, Fang Wang, Xing Pan, Jian Liu, Lijuan Wang, Guanyue Su, Jie Ma, Yinxu Dong, Zhili Xiong, Chufu Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis is often observed in the pathophysiology of depression. Antidepressant therapy can restore hippocampal neurogenesis to rescue the HPA axis regulation defects. Xiaochaihutang (XCHT), a famous Chinese herbal formula, has been used clinically in depressive disorders in China. Our previous studies have demonstrated XCHT improved depressive-like behaviors in chronic unpredictable mild stress rat, but the underlying mechanisms of XCHT on hippocampal neurogenesis and the HPA axis were still unclear...
October 13, 2016: Journal of Ethnopharmacology
Jian-Ying Wang, Ying Yuan, Xiao-Jun Chen, Sheng-Guang Fu, Lei Zhang, Yan-Long Hong, Sheng-Fu You, Yong-Qing Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Eucommia Ulmoides Oliv., a valuable Chinese herb, has shown a variety of health benefits. Despite the widespread clinical use of this herb to treat rheumatoid arthritis (RA) in Traditional Chinese Medicine (TCM), very few studies have described its anti-pathological effects or mechanism in RA. The present study investigated the mechanism of Eucommia Ulmoides Oliv. in an experimental collagen-induced arthritis (CIA) rat model. MATERIALS AND METHODS: The effects of four different Eucommia Ulmoides Oliv...
October 12, 2016: Journal of Ethnopharmacology
Kai-Chih Hung, Hui-Ju Huang, Yi-Ting Wang, Anya Maan-Yuh Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Neuroinflammation, oxidative stress, and protein aggregation form a vicious cycle in the pathophysiology of Parkinson's disease (PD); activated microglia is the main location of neuroinflammation. A Chinese medicine book, "Shanghan Lun", known as the "Treatises on Cold damage Diseases" has suggested that Scutellaria baicalensis Georgi is effective in treating CNS diseases. The anti-inflammatory mechanisms of baicalein, a phenolic flavonoid in the dried root of Scutellaria baicalensis Georgi, remain to be explored...
October 11, 2016: Journal of Ethnopharmacology
Tao Zheng, Xincai Hao, Qibin Wang, Li Chen, Si Jin, Fang Bian
ETHNOPHARMACOLOGICAL RELEVANCE: The seed of Entada phaseoloides (L.) Merr. (Entada phaseoloides) has been long used as a folk medicine for the treatment of Diabetes mellitus by Chinese ethnic minorities. Recent reports have demonstrated that total saponins from Entada phaseoloides (TSEP) could reduce fasting blood glucose in type 2 diabetic rats. However, the mechanism has not been fully elucidated. The aim of this study was to explore the underlying mechanisms of TSEP on type 2 Diabetes mellitus (T2DM)...
October 11, 2016: Journal of Ethnopharmacology
Bin Qi, Shan Wang, Qiu Wang, He Zhang, Xue-Yuan Bai, Hui-Nan He, Wei-Jie Sun, Li Liu, Da-Qing Zhao
ETHNOPHARMACOLOGICAL RELEVANCE: Panax quinquefolius L. has been used as a proverbial tonic in oriental countries for hundreds of years. It is used as a traditional medicinal herb to nourish vitality. AIM OF THE STUDY: The purpose of our study was to inquiry the activation effects on murine peritoneal macrophages of a novel protein separated from the roots of Panax quinquefolius L. MATERIALS AND METHODS: In our work, a novel protein of the roots of American ginseng (AGNP) was separated and purified from the roots of Panax quinquefolius L...
October 11, 2016: Journal of Ethnopharmacology
Rosa Mia F Cabanting, Loida M Perez
ETHNOPHARMACOLOGICAL RELEVANCE: Rice (Oryza sativa L.) remains as one the most important staple food of the Philippines with an overabundance of varieties and gastronomic use. Despite this, no published comprehensive ethnobotanical information exists for the exclusive subject on Philippine traditional rice varieties and their ethnomedicinal value. AIM OF THE STUDY: To identify and collect traditional rice landrace with ethnomedicinal application from local communities of the Philippines; and document the application, traditional preparation and administration of these plants...
October 11, 2016: Journal of Ethnopharmacology
Jyoti Dahiya, Jitender Singh, Ashwani Kumar, Anupam Sharma
ETHNOPHARMACOLOGICAL RELEVANCE: Leaves of M. koenigii Linn. Spreng (Rutaceae) have been used as traditional medicine for anxiety disorders. Aim of the study was to isolate antianxiety principle(s) from the leaves of M. koenigii using bioactivity guided approach. MATERIAL AND METHODS: Hydroalcoholic extract of M. koenigii leaves was prepared using soxhlet apparatus, and the same was evaluated for antianxiety activity at 250, 500 and 750mg/kg, po, using Elevated plus-maze (EPM)...
October 10, 2016: Journal of Ethnopharmacology
Mohammad Charehsaz, Rengin Reis, Sinem Helvacioglu, Hande Sipahi, Etil Guzelmeric, Ebru Turkoz Acar, Gamze Cicek, Erdem Yesilada, Ahmet Aydin
ETHNOPHARMACOLOGICAL RELEVANCE: Styrax liquidus is a resinous exudate (balsam) obtained from the wounded trunk of the Liquidambar orientalis Mill. (Hamamelidaceae). Styrax has been used for treatment of various ailments in Turkish folk medicine such as skin problems, peptic ulcers, nocturnal enuresis, parasitic infections, antiseptic or as expectorant. AIM OF STUDY: In spite of frequent use of styrax in Turkish folk medicine as well as once as a stabilizer in perfumery industry, negative reports have been noticed by the international authority for restriction its use based on some limited evidences from an in vitro study...
October 10, 2016: Journal of Ethnopharmacology
Yong Wang, Ting-Ting Ma, Na-Na Gao, Xiao-Ling Zhou, Jiang Hong, Rui Guo, Li-Na Jia, Hong Chang, Ying Gao, Zhi-Min Gao, Lei Pan
ETHNOPHARMACOLOGICAL RELEVANCE: Tongxinluo (TXL),which is a Chinese medicine rooted from traditional used herbs, has been used in clinic to treat cardiovascular and cerebrovascular diseases. However, it remains unknown whether TXL alleviates low pressure hypoxic pulmonary hypertension. AIM OF THE STUDY: Here, we aimed to observe the influence of TXL on pulmonary hypertension in a rat model that exposed to high altitude environment characterized by low pressure hypoxia...
October 10, 2016: Journal of Ethnopharmacology
Irma Izani Mohamad Isa, Suhaili Abu Bakar, Siti Farah Md Tohid, Abdul Manan Mat Jais
ETHNOPHARMACOLOGICAL RELEVANCE: Haruan, Channa striatus, is a freshwater fish which has been well-known locally to accelerate wound healing during post-operative and post-partum periods. The fish extract also has potent anti-inflammatory and analgesic properties. AIM OF THE STUDY: To assess topical anti-inflammatory effect of Haruan cream on 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced chronic-like dermatitis in mice. MATERIALS AND METHODS: Male ICR mice were randomized into six groups of five mice each: acetone (vehicle), TPA alone (negative control), three Haruan treatment groups (Haruan 1%, Haruan 5% and Haruan 10%) and hydrocortisone 1% (positive control)...
October 9, 2016: Journal of Ethnopharmacology
Wararut Buncharoen, Kanokporn Saenphet, Supap Saenphet, Chatchote Titaram
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional medicine has used Uvaria rufa Blume as an ethnomedicinal plant for treating fever, skin allergies, intestinal ulcers and prostate disorders including BPH. However, no scientific evidence supports the traditional use. AIM OF THE STUDY: This study aimed to evaluate the therapeutic potential of U. rufa on BPH using in vitro and in vivo models. MATERIALS AND METHODS: In vitro studies screened the efficacy of a 5α-reductase (5αR) inhibition and antioxidant activity of petroleum ether, ethyl acetate, ethanol and aqueous extracts from the stem of U...
October 9, 2016: Journal of Ethnopharmacology
Jingrui Chen, Wenjie Cao, Patrick Fordjour Asare, Ming Lv, Zhu Yan, Lan Li, Jing Wei, Hui Gao, Han Zhang, Haoping Mao, Xiumei Gao, Guanwei Fan
ETHNOPHARMACOLOGICAL RELEVANCE: Danhong injection (DHI) is a standardized product extracted from Radix et Rhizoma Salviae Miltiorrhizae and Flos Carthami ,which has been long applied mainly used to treat ischemic encephalopathy and cardiac diseases including myocardial infarction and angina in clinical practice. AIM OF THE STUDY: Aim of this study was to investigate the salutary effects of DHI by slowing ventricular remodeling and improving cardiac function after myocardial infarction (MI) in rats...
October 8, 2016: Journal of Ethnopharmacology
Hajer Taleb, Sarah E Maddocks, R Keith Morris, Ara D Kanekanian
ETHNOPHARMACOLOGICAL RELEVANCE: Date fruit, Phoenix dactylifera L. has traditionally been used as a medicine in many cultures for the treatment of a range of ailments such as stomach and intestinal disorders, fever, oedema, bronchitis and wound healing. AIM OF THE REVIEW: The present review aims to summarise the traditional use and application of Phoenix dactylifera date fruit in different ethnomedical systems, additionally the botany and phytochemistry are identified...
October 8, 2016: Journal of Ethnopharmacology
Paul Owusu Donkor, Ying Chen, Liqin Ding, Feng Qiu
ETHNOPHARMACOLOGICAL RELEVANCE: Ligusticum species (Umbelliferae) have been widely used in traditional Chinese medicine, Korean folk medicine and Native American medicine for their medicinal and nutritional value. Decoctions of the rhizomes are used in treatment and prophylaxis of migraine, anaemia and cardiovascular conditions including stroke. AIM OF STUDY: This review is intended to fully compile the constituents of locally and traditionally used Ligusticum species, present their bioactivities and highlight potential leads for future drug design, and thus, provide a reference for further research and application of these species...
October 8, 2016: Journal of Ethnopharmacology
Peter M Waziri, Rasedee Abdullah, Swee Keong Yeap, Abdul Rahman Omar, Ahmad Bustamam Abdul, Nur Kartinee Kassim, Ibrahim Malami, Thiruventhan Karunakaran, Mustapha Umar Imam
ETHNOPHARMACOLOGICAL RELEVANCE: Clausena excavata Burm.f. is used locally in folk medicine for the treatment of cancer in South East Asia. AIM OF THE STUDY: To determine the mechanism action of pure clausenidin crystals in the induction hepatocellular carcinoma (hepG2) cells apoptosis. MATERIALS AND METHODS: Pure clausenidin was isolated from Clausena excavata Burm.f. and characterized using (1)H and (13)C NMR spectra. Clausenidin-induced cytotoxicity was determined by MTT assay...
October 8, 2016: Journal of Ethnopharmacology
Peter Lorenz, Miriam Heinrich, Manuel Garcia-Käufer, Franziska Grunewald, Silke Messerschmidt, Anja Herrick, Kim Gruber, Christiane Beckmann, Matthias Knoedler, Roman Huber, Carmen Steinborn, Florian C Stintzing, Carsten Gründemann
ETHNOPHARMACOLOGICAL RELEVANCE: Oak bark has been used since ancient times in Europaen ethnomedicine because of its adstringent, antimicrobial and hemostatic features, e.g. as a remedy for the treatment of wounds and skin diseases. PURPOSE: Oak bark tannins are considered as bioactive natural products, interacting with surface proteins of mucous membranes and might be beneficial for the treatment of allergic diseases. This study investigated the effect of an oak bark decoction (OBD) and isolated tannin fractions on the degranulation capacity and cytokine/chemokine release from rat basophilic cells and human mast cells in vitro, which are essential for the initiation of early- and late-phase allergic reactions...
October 7, 2016: Journal of Ethnopharmacology
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