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Journal of Ethnopharmacology

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https://www.readbyqxmd.com/read/29031784/isobarictags-for-relative-and-absolute-quantitation-itraq-based-proteomics-for-the-investigation-of-the-effect-of-huganqingzhi-on-non-alcoholic-fatty-liver-disease-in-rats
#1
Fan Xia, Xiaorui Yao, Waijiao Tang, Chunxin Xiao, Miaoting Yang, Benjie Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Hugan Qingzhi tablet (HQT), a traditional Chinese medicine formula has been adopted for preventing and treating nonalcoholic fatty liver disease (NAFLD). AIM: In order to explore the anti-NAFLD mechanisms of HQT, iTRAQ-based proteomics was employed to investigate the expression profiles of proteins in NAFLD rats induced by high-fat diet after HQT treatment. MATERIALS AND METHODS: The NAFLD rat model was administration of high-fat diet (HFD) for 12weeks and administering HQT in a daily basis to the HFD groups...
October 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29031783/antidiabetic-effect-of-achillea-millefollium-through-multitarget-interactions-%C3%AE-glucosidases-inhibition-insulin-sensitization-and-insulin-secretagogue-activities
#2
Fabiola Chávez-Silva, Litzia Cerón-Romero, Luis Arias-Durán, Gabriel Navarrete-Vázquez, Julio Almanza-Pérez, Rubén Román-Ramos, Guillermo Ramírez-Ávila, Irene Perea-Arango, Rafael Villalobos-Molina, Samuel Estrada-Soto
ETHNOPHARMACOLOGICAL IMPORTANCE: Achillea millefolium L. (Asteraceae) is a perennial herb used in Mexican folk medicine for treatment of several pathologies, including inflammatory and spasmodic gastrointestinal disorders, hepatobiliary complaints, overactive cardiovascular, respiratory ailments and diabetes. AIM OF THE STUDY: To evaluate the potential antidiabetic effect in vivo and to establish the potential mode of action through in vitro approaches of Achillea millefolium...
October 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29032117/salvia-miltiorrhiza-protects-adenine-induced-chronic-renal-failure-by-regulating-the-metabolic-profiling-and-modulating-the-nadph-oxidase-ros-erk-and-tgf-%C3%AE-smad-signaling-pathways
#3
Hongdie Cai, Shulan Su, Yonghui Li, Huiting Zeng, Zhenhua Zhu, Jianming Guo, Yue Zhu, Sheng Guo, Li Yu, Dawei Qian, Yuping Tang, Jinao Duan
ETHNOPHARMACOLOGICAL RELEVANCE: Chronic renal failure (CRF) is defined as a progressive and irreversible loss of renal function and associated with inflammation and oxidative stress. Salvia miltiorrhiza (SM) is an important Chinese herb used in traditional Chinese medicine with notable effects on CRF. It significantly inhibited the elevation of serum creatinine (Scr), blood urea nitrogen (BUN) and urine protein (UP) in adenine-induced CRF rats, while the action mechanism need to be illuminated deeply...
October 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29030263/the-role-of-endemic-plants-in-mauritian-folkloric-medicine-therapeutic-efficacy-or-placebo-effect
#4
REVIEW
Nawraj Rummun, Vidushi S Neergheen-Bhujun, Kersley B Pynee, Cláudia Baider, Theeshan Bahorun
ETHNOPHARMACOLOGICAL RELEVANCE: The Mauritian endemic flora has been recorded to be used as medicinal for nearly 300 years. Despite acceptance of these endemic plants among the local population, proper documentation of their therapeutic uses is scarce. This review aims at summarizing documented traditional uses of Mauritian endemic plants with existing scientific data of their alleged bioactivities, showing there is a need for more stringent evidence-based validations for clinical efficacy...
October 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28993280/antidiabetic-activities-of-entagenic-acid-in-type-2-diabetic-db-db-mice-and-l6-myotubes-via-ampk-glut4-pathway
#5
Hui Xiong, Shengnan Zhang, Zhongqiu Zhao, Ping Zhao, Lvyi Chen, Zhinan Mei
ETHNOPHARMACOLOGICAL RELEVANCE: Entada phaseoloides (L.) Merr., a traditional Chinese folk medicine, has been used in treating diabetes and other inflammatory disorders. Our previous study revealed that the triterpene saponins in E.Phaseoloides possessed an antidiabetic effect in type 2 diabetic rats by activating AMP-activated protein kinase (AMPK). Entagenic acid, the principal aglycon, isolated from the seed kernels of E. phaseoloides, has been proposed to possess a significant role in the antidiabetic effect, however, its actual effect and pertinent mechanisms are still unknown...
October 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28993279/anti-scorpion-venom-activity-of-thapsia-garganica-methanolic-extract-histopathological-and-biochemical-evidences
#6
Btissam Bouimeja, Moulay Abdelmonaim El Hidan, Oulaid Touloun, Mehdi Ait Laaradia, Loubna Ait Dra, Noureddine El Khoudri, Abderrahman Chait, Ali Boumezzough
ETHNOPHARMACOLOGICAL RELEVANCE: Thapsia garganica, is a herbal medicine traditionally used as diuretic, emetic and purgative. It is also used as anti-scorpion venom in Morocco; however, its protective effects against scorpion venom remain elusive. AIM OF THE STUDY: The present study was undertaken to evaluate anti-venom activity of T. garganica in vivo through histological and biochemical studies. MATERIALS AND METHODS: Methanolic leaves extract of T...
October 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28989011/isoflavonoids-as-wound-healing-agents-from-ononidis-radix
#7
Burçin Ergene Öz, Gülçin Saltan İşcan, Esra Küpeli Akkol, İpek Süntar, Özlem Bahadır Acıkara
ETHNOPHARMACOLOGICAL RELEVANCE: Dried roots of Ononis spinosa L. are traditionally used for their diuretic, anti-inflammatory and wound healing effects. AIM OF THE STUDY: Isolation of the bioactive compounds of Ononis spinosa L. subsp. leiosperma (Boiss.) Sirj. MATERIALS AND METHODS: Ethyl acetate extract prepared from the roots of Ononis spinosa L. subsp. leiosperma (Boiss.) Sirj. was subjected to silica gel column. The fractions were tested for their wound healing and anti-inflammatory activities...
October 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28987599/anti-sepsis-protection-of-xuebijing-injection-is-mediated-by-differential-regulation-of-pro-and-anti-inflammatory-th17-and-t-regulatory-cells-in-a-murine-model-of-polymicrobial-sepsis
#8
Xi Chen, Yuxin Feng, Xiya Shen, Guixiang Pan, Guanwei Fan, Xiumei Gao, Jihong Han, Yan Zhu
ETHNOPHARMACOLOGICAL RELEVANCE: Xuebijing injection (XBJ), a Chinese herbal medicine containing extracts from 5 herbs, is frequently used as an add-on with standard therapies to treat sepsis or septic shock with fewer side effects in China. Nonetheless, its mechanism of action on septic shock remains to be unveiled. We explored the differential effects of XBJ on subtypes of CD4+ T cell differentiation and septic shock protection in a murine model to understand the contribution of XBJ to regulation of the inflammation-immune axis function...
October 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28987598/the-brazilian-market-of-herbal-medicinal-products-and-the-impacts-of-the-new-legislation-on-traditional-medicines
#9
Ana Cecília Bezerra Carvalho, Túlio Nader Lana, João Paulo Silvério Perfeito, Dâmaris Silveira
ETHNOPHARMACOLOGICAL RELEVANCE: the herbal medicinal products (HMP) market is expanding in the world, an expansion that has not occurred in Brazil when considering the number of licensed products. Despite being a megadiverse country, the number of HMP licensed in Brazil is small, and the number of HMP obtained from native species is even smaller. A new legislation for herbal products licensing, which divides the products into two categories, Herbal Medicine (HM) and Traditional Herbal Product (THP) was launched in Brazil focusing on traditional use, as well as a law regulating the use of biodiversity and traditional knowledge...
October 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28986333/protective-effect-of-danhong-injection-combined-with-naoxintong-capsule-on-cerebral-ischemia-reperfusion-injury-in-rats
#10
Jiayang Wan, Haofang Wan, Rongbin Yang, Haitong Wan, Jiehong Yang, Yu He, Huifen Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Danhong Injection (DHI) and Naoxintong Capsule (NXT) are renowned traditional Chinese medicine in China. The drug combination of DHI and NXT is frequently applied for the treatment of cardiovascular and cerebrovascular diseases in clinic. However, there had been no pharmacological experiment studies of interaction between DHI and NXT. Due to the drug interactions, exploring their interaction profile is of great importance. MATERIAL AND METHODS: In this study, focal cerebral I/R injury in adult male Sprague-Dawley rats were induced by transient middle cerebral artery occlusion (tMCAO) for 1h followed by reperfusion...
October 3, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28986332/anticonvulsant-effects-of-senna-spectabilis-on-seizures-induced-by-chemicals-and-maximal-electroshock
#11
Nkantchoua Nkamguie Gisele Claudine, Njapdounke Kameni Jacqueline Stephanie, Fifen Jean Jules, Taiwe Sotoing Germain, Ojong Lucie Josiane, Kandeda Kavaye Antoine, Ngo Bum Elisabeth
Senna spectabilis (Fabaceae) is one of the medicinal plants used in Cameroon by traditional healers to treat epilepsy, constipation, insomnia, anxiety. The present study aimed to investigate the anticonvulsant effects of Senna spectabilis decoction induced by maximal electroshock (MES), pentylenetetrazole (PTZ), pilocarpine (PC) and its possible action mechanisms in animal models using flumazenil (FLU), methyl-ß-carboline-3-carboxylate (BC) and bicuculline (BIC). Senna spectabilis decoction (106.5 and 213...
October 3, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28970156/leishmanicidal-activity-of-the-root-bark-of-erythrophleum-ivorense-fabaceae-and-identification-of-some-of-its-compounds-by-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-uplc-qtof-ms-ms
#12
Francis A Armah, Isaac K Amponsah, Abraham Y Mensah, Rita A Dickson, Paul A Steenkamp, Ntakadzeni E Madala, Christian K Adokoh
ETHNOPHARMACOLOGICAL RELEVANCE: Leishmaniasis is one of the neglected tropical disease caused by a protozoan of the genus Leishmania transmitted by sandflies. High cost and lack of oral formulation of existing drugs, rapid developments of resistance by the parasite coupled with serious side effects require new treatments to augment or replace currently available therapies. The major merits of herbal medicine seem to demonstrate perceived efficacy, low incidence of serious adverse effects and low cost...
September 29, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28970155/anti-inflammatory-effects-of-perillae-herba-ethanolic-extract-against-tnf-%C3%AE-ifn-%C3%AE-stimulated-human-keratinocyte-hacat-cells
#13
Ju-Hye Yang, Jae-Myung Yoo, Esther Lee, BoHyoung Lee, Won-Kyung Cho, Kwang-Il Park, Jin Yeul Ma
ETHNOPHARMACOLOGICAL RELEVANCE: Perillae Herba is a perennial plant that is widely distributed throughout Asia. The leaves of Perillae Herba have been widely used to treat various diseases, such as cold due to wind-cold, headache, cough, abdominal fullness, distention, and fish and crab poisoning. MATERIALS AND METHODS: To assess the anti-inflammatory activity of Perillae Herba leaf ethanolic extract (PHE) in human keratinocytes, we measured the tumor necrosis factor (TNF)-α/interferon (IFN)-γ-induced mRNA expression and production of proinflammatory chemokines such as thymus and activation-regulated chemokines; regulated on activation, normal T cell expressed and secreted; interleukin (IL)-6; and IL-8 in HaCaT cells...
September 29, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28970154/evaluation-of-extracts-prepared-from-16-plants-used-in-yao-ethnomedicine-as-potential-anticancer-agents
#14
Nadin Marwan Almosnid, Xiaolei Zhou, Lihe Jiang, Amy Ridings, Deborah Knott, Shuo Wang, Fan Wei, Jingquan Yuan, Elliot Altman, Ying Gao, Jianhua Miao
ETHNOPHARMACOLOGICAL RELEVANCE: Medicines of the Yao ethnic group in China are a special branch of traditional Chinese medicine (TCM) and are well documented for use in disease prevention. According to an ethnopharmacological survey, there are 1392 species of medicinal plants that have been documented as Yao ethnomedicines and 104 of these species are used routinely. This study evaluated a partial collection of these 104 core plant species for their potential as anticancer agents. MATERIAL AND METHODS: A literature study of scientific journals and books in the local language was conducted...
September 29, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28970153/the-croton-megalobotrys-m%C3%A3-ll-arg-traditional-medicine-in-hiv-aids-management-documentation-of-patient-use-in-vitro-activation-of-latent-hiv-1-provirus-and-isolation-of-active-phorbol-esters
#15
Ian Tietjen, Barbara N Ngwenya, Ghislain Fotso, David E Williams, Sundana Simonambango, Bonaventure T Ngadjui, Raymond J Andersen, Mark A Brockman, Zabrina L Brumme, Kerstin Andrae-Marobela
ETHNOPHARMACOLOGICAL RELEVANCE: Current HIV therapies do not act on latent cellular HIV reservoirs; hence they are not curative. While experimental latency reversal agents (LRAs) can promote HIV expression in these cells, thereby exposing them to immune recognition, existing LRAs exhibit limited clinical efficacy and high toxicity. We previously described a traditional 3-step medicinal plant regimen used for HIV/AIDS management in Northern Botswana that inhibits HIV replication in vitro...
September 29, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28970152/in-vitro-multimodal-effect-of-trichilia-catigua-a-juss-meliaceae-bark-aqueous-extract-in-cns-targets
#16
João Bernardo, Federico Ferreres, Ángel Gil-Izquierdo, Romeu António Videira, Patrícia Valentão, Francisco Veiga, Paula B Andrade
ETHNOPHARMACOLOGICAL RELEVANCE: The bark of Trichilia catigua A. Juss. (Meliaceae), popularly known as "big catuaba", is traditionally used in Brazilian folk medicine for its neuroactive potential as memory stimulant, and antinociceptive and antidepressant effects. AIM OF THE STUDY: To study the aqueous extract of T. catigua bark as dual inhibitor of monoamine oxidase A (MAO-A) and acetylcholinesterase (AChE). To explore its antioxidant potential through interaction with xanthine/xanthine oxidase (X/XO) pathway, and to attempt a relationship between its phenolic profile and effects displayed...
September 29, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28965754/patchouli-alcohol-isolated-from-pogostemon-cablin-mediates-endothelium-independent-vasorelaxation-by-blockade-of-ca-2-channels-in-rat-isolated-thoracic-aorta
#17
Guan-Ying Hu, Cheng Peng, Xiao-Fang Xie, Liang Xiong, San-Yin Zhang, Xiao-Yu Cao
ETHNOPHARMACOLOGICAL RELEVANCE: The aerial parts of Pogostemon cablin (Blanco) Benth. for the treatment of cardiodynia have been documented in Mingyi Bielu of late Han Dynasty, in addition to that the Ca(2+) antagonized activities of P. cablin and its critically pharmacological ingredient patchouli alcohol (PA) were reported previously. AIM OF THE STUDY: To investigate the relaxant effects of PA on rat isolated thoracic aortas and further explore its potential mechanisms of actions...
September 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28965753/leishmania-mexicana-cell-death-achieved-by-cleoserrata-serrata-jacq-iltis-learning-from-maya-healers
#18
Lorena Noemi Alamilla-Fonseca, José Delgado-Domínguez, Jaime Zamora-Chimal, Rocely Buenaventura Cervantes-Sarabia, Adelina Jiménez-Arellanes, José Fausto Rivero-Cruz, Ingeborg Becker
ETHNOPHARMACOLOGICAL RELEVANCE: Aerial parts of Cleoserrata serrata (Jacq.) Iltis are widely used in South-Central Mexico to treat wounds and bacterial skin infections and in Panama by Kuna, Ngöbe-Buglé, and Teribe Indians for tropical warm baths and by Kunas in the form of "Ina kuamakalet" for snakebites. AIMS OF THE STUDY: To evaluate the effect of Cleoserrata serrata extract on growth and viability of L. mexicana amastigotes and promastigotes in vitro, as well as on bacteria that usually co-infect skin ulcers...
September 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28964871/anti-ulcer-and-anti-helicobacter-pylori-potentials-of-the-ethyl-acetate-fraction-of-physalis-alkekengi-l-var-franchetii-solanaceae-in-rodent
#19
Yong Wang, Sui Lou Wang, Jiong Yi Zhang, Xiao Ning Song, Zhi Yong Zhang, Jing Feng Li, Song Li
ETHNOPHARMACOLOGICAL RELEVANCE: Physalis alkekengi L. var. franchetii (Solanaceae) has been widely used in Chinese folk medicine due to its wide distribution throughout the country, for the treatment of a wide range of diseases including heat and cold, sore throat, fever, fungal infection, inflammation, toothache, rheumatism, burn, analgesic, ulcer and urinary diseases. However, the effect of P. alkekengi var. franchetii on ulcer and Helicobacter pylori infection has not been reported to date...
September 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28964870/hemostasis-and-uterine-contraction-promoting-effect-of-the-extract-from-drugs-in-the-zi-yin-tiao-jing-granule-a-traditional-chinese-compound-preparation
#20
Qing Tang, Sheng Yang, Jie Tong, Xu Li, Junjie Wu, Senhong Wang, Jifen Zhang, Yi Chen, Xiaoyu Xu
ETHNOPHARMACOLOGICAL RELEVANCE: Zi-Yin-Tiao-Jing granule (ZG) is a traditional Chinese medicine compound preparation for perimenopausal dysfunctional uterine bleeding. It is made from 9 Chinese crude drugs based on a modified traditional Chinese prescription recorded in Fu Qingzhu Nvke as Guben Zhibeng Tang. AIM OF THE STUDY: This study aimed to investigate the hemostasis and uterine contraction promoting effect of quality controlled ZG extract on animals as a preclinical study...
September 28, 2017: Journal of Ethnopharmacology
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