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Clinical Cardiology

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https://www.readbyqxmd.com/read/28218398/changes-in-left-ventricular-function-after-spontaneous-coronary-artery-dissection
#1
Christopher Franco, Andrew Starovoytov, Milad Heydari, G B John Mancini, Eve Aymong, Jacqueline Saw
BACKGROUND: Spontaneous healing of spontaneous coronary artery dissection (SCAD) and left ventricular ejection fraction (LVEF) recovery is frequently observed clinically. However, LVEF on presentation and follow-up imaging has not been described. HYPOTHESIS: We hypothesize that LV dysfunction improves at follow-up after initial SCAD presentation. METHODS: We included patients with nonatherosclerotic SCAD prospectively followed at Vancouver General Hospital, who had baseline assessment of LVEF and wall-motion abnormality (WMA) during their index presentation...
February 20, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28207168/design-and-rationale-of-the-ebbinghaus-trial-a-phase-3-double-blind-placebo-controlled-multicenter-study-to-assess-the-effect-of-evolocumab-on-cognitive-function-in-patients-with-clinically-evident-cardiovascular-disease-and-receiving-statin-background-lipid
#2
Robert P Giugliano, Francois Mach, Kenton Zavitz, Christopher Kurtz, Jingjing Schneider, Huei Wang, Anthony Keech, Terje R Pedersen, Marc S Sabatine, Peter S Sever, Narimon Honarpour, Scott M Wasserman, Brian R Ott
Some observational studies raised concern that statins may cause memory impairment, leading to a US Food and Drug Administration warning. Similar questions were raised regarding proprotein convertase subtilisin/kexin-type 9 inhibitors (PCSK9i) and neurocognitive function. No prospectively designed study has evaluated the relationship between long-term PCSK9i use and cognition changes. Patients with prior cardiovascular disease treated with maximally tolerated statin enrolled in FOURIER (the randomized, double-blind, placebo-controlled cardiovascular outcome study of the PCSK9i evolocumab) could participate in this prospective assessment of cognitive function (EBBINGHAUS)...
February 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28207162/plasma-oxidative-stress-and-inflammatory-biomarkers-are-associated-with-the-sizes-of-the-left-atrium-and-pulmonary-vein-in-atrial-fibrillation-patients
#3
Jin-Yi Li, Yan He, Hong-Hong Ke, Yu Jin, Zhi-Yuan Jiang, Guo-Qiang Zhong
BACKGROUND: Oxidative stress and inflammatory processes are responsible for the pathogenesis of AF, but their relationship with the sizes of the LA and PVs in AF patients remains unclear. HYPOTHESIS: Oxidative stress and inflammatory processes are associated with the sizes of the LA and PVs in AF patients. METHODS: 82 AF patients were compared to 30 control patients by using a case-control study design. Oxidative stress, inflammatory biomarkers and the sizes of the LA and PVs were detected...
February 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28191912/the-clinical-utility-of-normal-findings-on-noninvasive-cardiac-assessment-in-the-prediction-of-atrial-fibrillation
#4
Sanjay Venkatesh, Wesley T O'Neal, Stephen T Broughton, Amit J Shah, Elsayed Z Soliman
BACKGROUND: The absence of abnormalities on noninvasive cardiac assessment possibly confers a reduced risk of atrial fibrillation (AF) despite the presence of traditional risk factors. HYPOTHESIS: Normal findings on noninvasive cardiac assessment are associated with a lower risk of AF development. METHODS: We examined the clinical utility of normal findings on routine noninvasive cardiac assessment in 5331 participants (85% white; 57% women) from the Cardiovascular Health Study who were free of baseline AF...
February 13, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28191909/the-influence-of-chemotherapy-on-the-right-ventricle-did-we-forget-something
#5
REVIEW
Marijana Tadic, Cesare Cuspidi, Dagmara Hering, Lucia Venneri, Oleksandr Danylenko
BACKGROUND: A large number of chemotherapy-induced cardiovascular complications were discovered in studies over the last several decades. The focus of the majority of these studies was left ventricular (LV) remodeling. The aim of this article was to provide a comprehensive overview of potential mechanisms of chemotherapy-induced right ventricular (RV) remodeling and summarize clinical studies on this topic. HYPOTHESIS: Chemotherapy induces RV structural, functional, and mechanical changes...
February 13, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28191907/anthropometric-parameters-and-the-incidence-of-atrial-fibrillation-in-older-people-the-pro-v-a-study
#6
Caterina Trevisan, Stefania Maggi, Chiara Curreri, Giovanni Nante, Marianna Noale, Marina De Rui, Egle Perissinotto, Leonardo Sartori, Sabina Zambon, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
BACKGROUND: Atrial fibrillation (AF) has been associated with body size and central obesity, but the impact of different anthropometric measures in this relationship has been inadequately investigated. HYPOTHESIS: In this study, we examined the association between baseline anthropometric parameters with the incidence of AF in older people, hypothesizing that body size could impact the onset of AF more than fat distribution. METHODS: Our study included 1764 participants with a mean age of 74...
February 13, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28191906/intracardiac-echocardiography-for-verification-for-left-atrial-appendage-thrombus-presence-detected-by-transesophageal-echocardiography-the-actionice-ii-study
#7
Jakub Baran, Beata Zaborska, Roman Piotrowski, Malgorzata Sikora-Frąc, Ewa Pilichowska-Paszkiet, Piotr Kułakowski
BACKGROUND: Transesophageal echocardiography (TEE) remains the gold standard for exclusion of left atrial appendage (LAA) thrombus in patients scheduled for direct electrical cardioversion (DEC) or atrial fibrillation (AF) ablation. Recently, intracardiac echocardiography (ICE) of the pulmonary artery (PA) has been shown to provide excellent LAA images and to be useful in verification of equivocal TEE findings. HYPOTHESIS: ICE of the PA may have a role in detecting false-positive TEE results...
February 13, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28191905/st-elevation-acute-myocardial-infarction-in-pregnancy-2016-update
#8
REVIEW
Sahar Ismail, Cynthia Wong, Priya Rajan, Mladen I Vidovich
Acute myocardial infarction (AMI) during pregnancy or the early postpartum period is rare, but can be devastating for both the mother and the fetus. There have been major advances in the diagnosis and treatment of acute coronary syndromes in the general population, but there is little consensus on the approach to diagnosis and treatment of pregnant women. This article reviews the literature relating to the pathophysiology of AMI in pregnant patients and the challenges in diagnosis and treatment of ST-elevation myocardial infarction (STEMI) in this unique population...
February 13, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28139844/short-and-long-term-radiation-induced-cardiovascular-disease-in-patients-with-cancer
#9
REVIEW
Kirsten Melgaard Nielsen, Birgitte Vrou Offersen, Hanne Melgaard Nielsen, Merete Vaage-Nilsen, Syed Wamique Yusuf
Radiation-induced cardiovascular disease is well described as a late effect in cancer patients treated with radiation therapy. Advancements in surgery, radiotherapy, and chemotherapy have led to an increasing number of cancer survivors with resultant long-term side effects related to their cancer treatments. In this review, we describe the short- and long-term cardiovascular consequences of mediastinal radiotherapy and discuss the optimal cardiovascular assessments and diagnostic tools in asymptomatic and symptomatic patients...
January 31, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28139837/long-term-follow-up-of-arrhythmogenic-right-ventricular-cardiomyopathy-patients-with-an-implantable-cardioverter-defibrillator-for-prevention-of-sudden-cardiac-death
#10
Kang Yin, Ligang Ding, Yuqiu Li, Wei Hua
BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare inherited cardiomyopathywith a high burden of ventricular arrhythmia, which is an important cause of suddencardiac death (SCD). Implantable cardioverter-defibrillator (ICD) is believed to be the most reliable management against SCD. HYPOTHESIS: Ventricular arrhythmia does not necessarily confer a poor prognosis in ARVC patients with an ICD. METHODS: A total of 39 ARVC patients (34 male) implanted with an ICD at our electrophysiologycenter and followed up continuously were included in this study...
January 31, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28139836/personalized-assessment-based-and-tiered-medical-education-curriculum-integrating-treatment-guidelines-for-atrial-fibrillation
#11
Brian C Lee, Karyn D Ruiz-Cordell, Steven M Haimowitz, Cara Williams, Bruce S Stambler, Anthia Mandarakas
BACKGROUND: This continuing medical education (CME) curriculum utilizes the Learner Assessment Platform (LAP), providing learners with personalized educational pathways related to atrial fibrillation treatment. HYPOTHESIS: There are improvements in knowledge among physician learners after CME, especially among LAP learners. METHODS: In this LAP-based curriculum, an evaluation of learner deficits on designated learning objectives was conducted in tier 1 and used to direct learners to individualized tier 2 activities...
January 31, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28120392/impact-of-rotor-temperospatial-stability-on-acute-and-one-year-atrial-fibrillation-ablation-outcomes
#12
Muhammad Balouch, Esra Gucuk Ipek, Jonathan Chrispin, Rizma J Bajwa, Tarek Zghaib, Ronald D Berger, Hiroshi Ashikaga, Saman Nazarian, Joseph E Marine, Hugh Calkins, David D Spragg
BACKGROUND: The utility of rotor ablation using commercially available systems as an adjunct to pulmonary vein isolation (PVI) is controversial. Variable results may stem from heterogeneous practice patterns. We investigated whether a prespecified protocol to determine temperospatial rotor stability improved acute and intermediate outcomes following rotor ablation. HYPOTHESIS: Protocolized rotor mapping and ablation, with prespecified metrics to determine temporal rotor stability prior to ablation, will improve short- and long-term PVI/rotor ablation outcomes...
January 25, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28075503/correlation-between-cardiac-rhythm-left-atrial-appendage-flow-velocity-and-cha2-ds2-vasc-score-study-based-on-transesophageal-echocardiography-and-2-dimensional-speckle-tracking
#13
Kun Zuo, Lanlan Sun, Xinchun Yang, Xiuzhang Lyu, Kuibao Li
BACKGROUND: The CHA2 DS2 -VASc score is a classic predictor of stroke in patients with atrial fibrillation (AF). Decreased left atrial appendage flow velocity (LAA-FV) reflects the blood stasis, and left atrial (LA) strain is a manifestation of atrial remodeling. This study aimed to explore the effects of AF rhythm and CHA2 DS2 -VASc score in the development of thrombogenesis and their potential correlation with LAA-FV and LA strain. HYPOTHESIS: AF rhythm and high CHA2 DS2 -VASc score correlate independently with decreased LAA-FV, which can be predicted by LA strain...
January 11, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28075500/very-short-short-term-benefit-of-inpatient-outpatient-cardiac-rehabilitation-programs-after-coronary-artery-bypass-grafting-surgery
#14
Dejan Spiroski, Mojsije Andjić, Olivera Ilić Stojanović, Milica Lazović, Ana Djordjević Dikić, Miodrag Ostojić, Branko Beleslin, Snežana Kostić, Marija Zdravković, Dragan Lović
BACKGROUND: Exercise-based rehabilitation is an important part of treatment patients following coronary artery bypass graft (CABG) surgery. HYPOTHESIS: To evaluate effect of very short/short-term exercise training on cardiopulmonary exercise testing (CPET) parameters. METHODS: We studied 54 consecutive patients with myocardial infarction (MI) treated with CABG surgery referred for rehabilitation. The study population consisted of 50 men and 4 women (age 57...
January 11, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28075499/long-term-outcome-following-remote-ischemic-postconditioning-during-percutaneous-coronary-interventions-the-rip-pci-trial-long-term-follow-up
#15
Shahar Lavi, Nour Abu-Romeh, Sabrina Wall, Mistre Alemayehu, Ronit Lavi
The clinical value of ischemic conditioning during percutaneous coronary intervention (PCI) and mode of administration is controversial. Our aim was to assess the long-term effect of remote ischemic postconditioning among patients undergoing PCI. We randomized 360 patients undergoing PCI who presented with a negative troponin T at baseline into 3 groups: 2 groups received remote ischemic postconditioning (with ischemia applied to the arm in 1 group and to the thigh in the other group), and the third group acted as a control group...
January 11, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28026044/expression-of-programmed-cell-death-1-and-its-ligand-b7-homolog-1-in-peripheral-blood-lymphocytes-from-patients-with-peripartum-cardiomyopathy
#16
Guozhi Xia, Xiaopu Zheng, Xinye Yao, Xiaowei Yao, Zhongwei Liu, Junkui Wang
BACKGROUND: Immune response has been postulated to play a prominent role in the pathogenesis of peripartum cardiomyopathy (PPCM). Given the importance of programmed death (PD)-1 and its ligand B7 homologue 1 (B7-H1) costimulatory molecules as an immune regulatory pathway, this study aimed to investigate the effect of PD-1 and B7-H1 expression on immune response in peripheral blood lymphocytes from the patients with PPCM. HYPOTHESIS: PD-1 and B7-H1 may be involved in modulating immune response in PPCM...
December 27, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/28026031/patterns-and-predictors-of-lipid-lowering-therapy-in-patients-with-atherosclerotic-cardiovascular-disease-and-or-diabetes-mellitus-in-2014-insights-from-a-large-us-managed-care-population
#17
Dylan L Steen, Irfan Khan, Laura Becker, JoAnne M Foody, Katherine Gorcyca, Robert J Sanchez, Robert P Giugliano
BACKGROUND: Lowering low-density lipoprotein cholesterol with statins reduces risk of cardiovascular events. We examined patterns and predictors of filled prescriptions for lipid-lowering therapy (LLT) in subgroups of patients with atherosclerotic cardiovascular disease (ASCVD) and/or diabetes mellitus (DM). HYPOTHESIS: Statin treatment remains underutilized across subgroups of high CV risk patients. METHODS: Patients in the Optum Research Database with these criteria were included: age ≥20 years, 2 years continuous enrollment, and ASCVD and/or DM...
December 27, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/28026030/evaluation-of-left-ventricular-diastolic-function-profile-in-patients-with-pulmonary-hypertension-due-to-heart-failure-with-preserved-ejection-fraction
#18
Pejman Raeisi-Giglou, Louis Lam, Balaji K Tamarappoo, Jennie Newman, Raed A Dweik, Adriano R Tonelli
BACKGROUND: Echocardiography plays an important role in the diagnostic work up of heart failure with preserved ejection fraction (HFpEF). We sought to determine the left ventricular (LV) diastolic profile by echocardiography in patients diagnosed with pulmonary hypertension (PH) due to PH-HFpEF. HYPOTHESIS: The study of LV diastolic function by echocardiography has limitations in patients with HFpEF and PH, and certain LV diastolic determinations convey a worse prognosis...
December 27, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/28026027/the-contemporary-value-of-peak-creatine-kinase-mb-after-st-segment-elevation-myocardial-infarction-above-other-clinical-and-angiographic-characteristics-in-predicting-infarct-size-left-ventricular-ejection-fraction-and-mortality
#19
Minke H T Hartman, Ruben N Eppinga, Pieter J J Vlaar, Chris P H Lexis, Erik Lipsic, Joost D E Haeck, Dirk J van Veldhuisen, Iwan C C van der Horst, Pim van der Harst
BACKGROUND: Complex multimarker approaches to predict outcome after ST-elevation myocardial infarction (STEMI) have only considered a single baseline sample, while neglecting easily obtainable peak creatine kinase and creatine kinase-MB (CK-MB) values during hospitalization. METHODS: We studied 476 patients undergoing primary percutaneous coronary intervention for STEMI and cardiac magnetic resonance imaging (CMRI) at 4-6 months after STEMI. We determined the association with cardiac biomarkers (peak CK-MB, peak troponin T, N-terminal pro-brain natriuretic peptide), clinical and angiographic characteristics with infarct size, and LVEF, followed by association with mortality in 1120 STEMI patients...
December 27, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/28026025/impact-of-diabetes-on-mortality-in-peripheral-artery-disease-a-meta-analysis
#20
Mislav Vrsalovic, Ksenija Vucur, Ana Vrsalovic Presecki, Damir Fabijanic, Milan Milosevic
BACKGROUND: There are accumulating studies showing the association between diabetes and all-cause mortality in peripheral vascular disease. However, the results in these studies are conflicting regarding the impact of diabetes on outcome. HYPOTHESIS: Diabetes is associated with increased risk of mortality in peripheral artery disease. METHODS: Using MEDLINE and Scopus, we searched for studies published before January 2016. Additionally, studies were identified by manual search of references of original articles or review studies on this topic...
December 27, 2016: Clinical Cardiology
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