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Clinical Cardiology

S Serge Barold
No abstract text is available yet for this article.
February 20, 2018: Clinical Cardiology
Egidio Imbalzano, Marco Vatrano, Sebastiano Quartuccio, Roberto Ceravolo, Vincenzo Antonio Ciconte, Paola Rotella, Renato Pardeo, Giovanni Trapani, Pasquale De Fazio, Cristina Segura-Garcia, Rossella Costantino, Antonino Saitta, Giuseppe Mandraffino
BACKGROUND: Smoking cessation is correlated with several psychological, social, biological, and pharmacological aspects. The combined tendency to experience negative emotions and to inhibit the expression of these emotions is indicated as "type D personality," an independent risk marker for clinical outcome in cardiac disease. Despite this effect of type D personality on cardiovascular disease, it is still unclear whether this personality trait may influence smoking cessation after a myocardial infarction...
February 19, 2018: Clinical Cardiology
Divya Gupta, Nanette K Wenger
Peripartum cardiomyopathy is a rare cardiac condition, overall. However, in certain populations can be found frequently enough and the signs, symptoms, and management should be readily understood. Here we provide an updated overview of this topic.
February 16, 2018: Clinical Cardiology
Martha Gulati, Nanette K Wenger
No abstract text is available yet for this article.
February 15, 2018: Clinical Cardiology
Martha Gulati, Sharon L Mulvagh
Cardiovascular disease remains the leading cause of death in women in the United States and is a major public health issue for all women, but it is of increasing concern to breast cancer survivors. Advancements in early detection and breast cancer therapy have resulted in over 90% of women surviving 5 years past their diagnosis of breast cancer. Nonetheless, with increased survivorship from breast cancer, there has been an increase in cardiovascular disease in these women. The consequences of the treatments for breast cancer may increase the risk for cardiovascular disease...
February 15, 2018: Clinical Cardiology
Alisse Hauspurg, Wendy Ying, Carl A Hubel, Erin D Michos, Pamela Ouyang
Cardiovascular disease (CVD) remains the leading cause of death in women. Although traditional risk factors increase later-life CVD, pregnancy-associated complications additionally influence future CVD risk in women. Recent guidelines for the prevention of CVD in women have added adverse pregnancy outcomes as major CVD risk factors. Studies have shown that women with a history of preeclampsia, gestational diabetes, preterm delivery, and delivery of a small-for-gestational-age infant have an increased risk of developing cardiometabolic risk factors and subsequent CVD...
February 15, 2018: Clinical Cardiology
Ajar Kochar, Anne S Hellkamp, Yuliya Lokhnygina, W Schuyler Jones, Richard C Becker, Scott D Berkowitz, Günter Breithardt, Keith A A Fox, Jonathan L Halperin, Graeme J Hankey, Kenneth W Mahaffey, Christopher C Nessel, Daniel E Singer, Jonathan P Piccini, Manesh R Patel
BACKGROUND: Atrial fibrillation (AF) increases risk of stroke 5-fold. Carotid artery disease (CD) also augments the risk of stroke, yet there are limited data about the interplay of these 2 diseases and clinical outcomes in patients with comorbid AF and CD. HYPOTHESIS: Among patients with both AF and CD, use of rivaroxaban when compared with warfarin is associated with a lower risk of stroke. METHODS: This post hoc analysis from ROCKET AF aimed to determine absolute rates of stroke/systemic embolism (SE) and bleeding, and the efficacy and safety of rivaroxaban compared with warfarin in patients with AF and CD (defined as history of carotid occlusive disease or carotid revascularization [endarterectomy and/or stenting])...
February 1, 2018: Clinical Cardiology
Subodh R Devabhaktuni, Eyas Chakfeh, Ali O Malik, Joshua A Pengson, Jibran Rana, Chowdhury H Ahsan
Subvalvular aortic stenosis (SAS) is one of the common adult congenital heart diseases, with a prevalence of 6.5%. It is usually diagnosed in the first decade of life. Echocardiography is the test of choice to diagnose SAS. Surgical correction is the best treatment modality, and the prognosis is usually excellent. In this review, we describe the pathophysiology, diagnosis, prognosis, and management of SAS with a focus on different pathophysiologic mechanisms, diagnostic approach, and prognosis of the disease by reviewing the current literature...
January 29, 2018: Clinical Cardiology
Hisham Samir Roshdy, Ibtesam Ibrahim El-Dosouky, Mohammad Hassan Soliman
BACKGROUND: It is important to diagnose right ventricular (RV) infarction in the setting of acute inferior myocardial infarction (MI). We aimed to improve the diagnostic accuracy of RV infarction and identify a high-risk subset of inferior MI patients with proximal RCA lesions. HYPOTHESIS: We tried to find the link between speckle tracking and coronaries in high risk inferior infarction METHODS: This study included 68 patients within 24 hours of first acute inferior MI...
January 29, 2018: Clinical Cardiology
Ahmed N Mahmoud, Nikhil H Shah, Islam Y Elgendy, Nayan Agarwal, Akram Y Elgendy, Amgad Mentias, Amr F Barakat, Dhruv Mahtta, R David Anderson, Anthony A Bavry
The efficacy of second-generation drug-eluting stents (DES; eg, everolimus and zotarolimus) compared with bare-metal stents (BMS) in patients undergoing percutaneous coronary intervention was challenged recently by new evidence from large clinical trials. Thus, we aimed to conduct an updated systematic review and meta-analysis of randomized clinical trials (RCTs) evaluating the efficacy and safety of second-generation DES compared with BMS. Electronic databases were systematically searched for all RCTs comparing second-generation DES with BMS and reporting clinical outcomes...
January 25, 2018: Clinical Cardiology
Xingfu Huang, Yanjia Chen, Junhui Xiao, Hongxin Zhao, Yizhen Chen, Shenrong Liu, Liwei He, Zheng Huang, Haobin Zhou, Dingli Xu, Jian Peng
BACKGROUND: We aimed to explore electrophysiological characteristics of premature atrial contractions (PACs) originating from pulmonary veins (PVs) and non-PVs and to evaluate the effectiveness and safety of catheter ablation for PACs. HYPOTHESIS: Symptomatic PACs originated from different positions and whether could be ablated. METHODS: Symptomatic, frequent, and drug-refractory PAC patients were enrolled in this study. All patients underwent electrophysiological study and catheter ablation...
January 25, 2018: Clinical Cardiology
Matthew Budoff, J Brent Muhlestein, Viet T Le, Heidi T May, Sion Roy, John R Nelson
Despite reducing progression and promoting regression of coronary atherosclerosis, statin therapy does not fully address residual cardiovascular (CV) risk. High-purity eicosapentaenoic acid (EPA) added to a statin has been shown to reduce CV events and induce regression of coronary atherosclerosis in imaging studies; however, data are from Japanese populations without high triglyceride (TG) levels and baseline EPA serum levels greater than those in North American populations. Icosapent ethyl is a high-purity prescription EPA ethyl ester approved at 4 g/d as an adjunct to diet to reduce TG levels in adults with TG levels >499 mg/dL...
January 24, 2018: Clinical Cardiology
Xiao Feng Hu, Rui Zhan, Shanhu Xu, Junjun Wang, Jiong Wu, Xiaoli Liu, Yaguo Li, Linhui Chen
BACKGROUND: There is evidence suggesting that growth differentiation factor 15 (GDF-15) appears to be associated with stroke in patients with atrial fibrillation (AF). AF-related thromboembolic stroke is predominantly attributed to the thrombus from the left atrium (LA) or left atrial appendage (LAA). HYPOTHESIS: GDF-15 is related to LA/LAA thrombus in nonvalvular AF (NVAF) patients. METHODS: A total of 894 patients with NVAF without anticoagulation therapy were included in this study...
January 24, 2018: Clinical Cardiology
Minmin Sun, Xuesen Cao, Yao Guo, Xiao Tan, Lili Dong, Cuizhen Pan, Xianhong Shu
BACKGROUND: Right ventricular (RV) dysfunction is a major cause of death in patients undergoing maintenance hemodialysis (MHD). We used 3-dimensional speckle-tracking echocardiography (3DSTE) to evaluate long-term impacts of MHD on RV function. HYPOTHESIS: In this study, RV dysfunction in MHD patients will be revealed and studied in depth by 3DSTE. METHODS: Echocardiography was performed on 110 consecutively enrolled individuals: 30 controls and 80 patients with MHD...
January 24, 2018: Clinical Cardiology
Natalie C Ward, Jing Pang, Jacqueline D M Ryan, Gerald F Watts
There is considerable evidence for the role of low-density lipoprotein cholesterol (LDL-C) in the development of atherosclerotic cardiovascular disease. Although statin therapy remains the most frequency prescribed medication to reduce LDL-C and lower risk of cardiovascular disease, a considerable number of patients develop muscle-related side affects. This review summarizes recent literature supporting the role of nutraceuticals as LDL-C-lowering therapy in statin-intolerant patients, with evidence from our own clinical practices...
January 24, 2018: Clinical Cardiology
Craig I Coleman, Tatsiana Vaitsiakhovich, Elaine Nguyen, Erin R Weeda, Nitesh A Sood, Thomas J Bunz, Bernhard Schaefer, Anna-Katharina Meinecke, Daniel Eriksson
BACKGROUND: Schemas to identify bleeding-related hospitalizations in claims data differ in billing codes used and coding positions allowed. We assessed agreement across bleeding-related hospitalization coding schemas for claims analyses of nonvalvular atrial fibrillation (NVAF) patients on oral anticoagulation (OAC). HYPOTHESIS: We hypothesized that prior coding schemas used to identify bleeding-related hospitalizations in claim database studies would provide varying levels of agreement in incidence rates...
January 23, 2018: Clinical Cardiology
Kuo Zhang, Wenyao Wang, Shihua Zhao, Stuart D Katz, Giorgio Iervasi, A Martin Gerdes, Yi-Da Tang
BACKGROUND: Thyroid dysfunction and myocardial fibrosis are both associated with cardiovascular events in patients with dilated cardiomyopathy (DCM). HYPOTHESIS: The combination of thyroid hormone (TH) and myocardial fibrosis (detected by late gadolinium enhancement [LGE]) is an independent and incremental predictor of adverse events in DCM. METHODS: We consecutively enrolled 220 idiopathic DCM patients with thyroid function and LGE assessment at Fuwai Hospital (China) from January 2010 to October 2011 and followed up through December 2015...
January 23, 2018: Clinical Cardiology
Pierpaolo Pellicori, Alessia Urbinati, Jufen Zhang, Anil C Joseph, Pierluigi Costanzo, Elena Lukaschuk, Alessandro Capucci, John G F Cleland, Andrew L Clark
BACKGROUND: The pulmonary artery (PA) distends as pressure increases. HYPOTHESIS: The ratio of PA to aortic (Ao) diameter may be an indicator of pulmonary hypertension and consequently carry prognostic information in patients with chronic heart failure (HF). METHODS: Patients with chronic HF and control subjects undergoing cardiac magnetic resonance imaging were evaluated. The main PA diameter and the transverse axial Ao diameter at the level of bifurcation of the main PA were measured...
January 23, 2018: Clinical Cardiology
Jörg Scharrenbroich, Sandra Hamada, Andras Keszei, Jörg Schröder, Andreas Napp, Mohammad Almalla, Michael Becker, Ertunc Altiok
BACKGROUND: Two-dimensional speckle strain (2D STE) echocardiography can aid in the prognosis of acute myocardial infarction (AMI) and chronic coronary artery disease (CAD). HYPOTHESIS: Differences occur in the prediction of cardiac events using 2D STE in AMI vs CAD patients. METHODS: In this prospective study, 94 patients with a first AMI and successful revascularization, and 137 patients with stable CAD after complete revascularization were included...
January 23, 2018: Clinical Cardiology
Isac C Thomas, Nketi I Forbang, Michael H Criqui
Calcification of the coronary artery is a complex pathophysiologic process that is intimately associated with atherosclerosis. Extensive investigation has demonstrated the value of identifying and quantifying coronary artery calcium (CAC) in atherosclerotic cardiovascular disease (CVD) prognostication. However, over the last several years, an increasing body of evidence has suggested that CAC has underappreciated aspects that modulate, and at times attenuate, future CVD risk. The most commonly used measure of CAC, the Agatston unit, effectively models both higher density and higher area of CAC as risk factors for future CVD events...
January 22, 2018: Clinical Cardiology
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