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Clinical Cardiology

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https://www.readbyqxmd.com/read/30178565/national-trends-in-hospitalizations-and-outcomes-in-patients-with-alcoholic-cardiomyopathy
#1
Pradhum Ram, Kevin Bryan Lo, Mahek Shah, Brijesh Patel, Janani Rangaswami, Vincent M Figueredo
BACKGROUND: Numerous studies have shown conflicting results regarding the natural history and outcomes with alcoholic cardiomyopathy (AC). HYPOTHESIS: Determining the trends in hospitalization among patients with AC and associated outcomes will facilitate a better understanding of this disease METHODS: We conducted our analysis on discharge data from the Nationwide Inpatient Sample (HCUP-NIS) from 2002 through 2014. We obtained data from patients aged ≥18 years with diagnosis of 'Alcoholic Cardiomyopathy'...
September 4, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30178507/meta-analysis-of-randomized-controlled-trials-on-atrial-fibrillation-ablation-in-patients-with-heart-failure-with-reduced-ejection-fraction
#2
Aiman Smer, Mohsin Salih, Yousef H Darrat, Abdulghani Saadi, Raviteja Guddeti, Toufik Mahfood Haddad, Amjad Kabach, Mohamed Ayan, Alok Saurav, Hussam Abuissa, Claude S Elayi
BACKGROUND: The role of catheter ablation (CA) is increasingly recognized as a reasonable therapeutic option in patients with atrial fibrillation (AF) and heart failure (HF). HYPOTHESIS: We aimed to compare CA to medical therapy in AF patients with HF with reduced ejection fraction (HFrEF). METHODS: We searched the literature for randomized clinical trials comparing CA to medical therapy in this population. RESULTS: Six trials with a total of 775 patients were included...
September 3, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30144129/evaluation-of-anticoagulation-use-and-subsequent-stroke-in-patients-with-atrial-fibrillation-after-empiric-surgical-left-atrial-appendage-closure-a-retrospective-case-control-study
#3
Daniel O Johnsrud, Rowlens M Melduni, Brian Lahr, Xiaoxi Yao, Kevin L Greason, Peter A Noseworthy
BACKGROUND: Surgical exclusion of the left atrial appendage (LAA) can be performed at the time of cardiac operation as a potential modality to decrease cardioembolic risk attributable to atrial fibrillation (AF), but it remains unclear if this decreases stroke incidence. Furthermore, it is not known whether LAA exclusion impacts the decision to discontinue anticoagulation impacting subsequent stroke risk. HYPOTHESIS: LAA exclusion does not significantly alter subsequent anticoagulation use or stroke incidence...
August 24, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30144126/thyroid-stimulating-hormone-elevation-as-a-predictor-of-long-term-mortality-in-patients-with-acute-myocardial-infarction
#4
Suk Min Seo, Yoon-Seok Koh, Hun-Jun Park, Dong Bin Kim, Sung Ho Her, Jong Min Lee, Chul Soo Park, Pum-Joon Kim, Hee Yeol Kim, Ki Dong Yoo, Doo Soo Jeon, Young Keun Ahn, Myung Ho Jeong, Wook Sung Chung, Ki-Bae Seung
BACKGROUND: Hypothyroidism has been known to be associated with hyperlipidemia, endothelial dysfunction and atherosclerosis. Elevation of thyroid-stimulation hormone (TSH) is a gold standard to detect these conditions. However, no large studies have investigated the association between TSH elevation and long-term clinical outcomes in patients with acute myocardial infarction (AMI). HYPOTHESIS: Hypothyroidism is associated with higher mortality in patients with AMI...
August 24, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30144123/left-atrial-size-and-function-in-a-south-asian-population-and-their-potential-influence-on-the-risk-of-atrial-fibrillation
#5
James O'Neill, Peter P Swoboda, Sven Plein, Muzahir H Tayebjee
BACKGROUND: South Asians have a low prevalence of atrial fibrillation (AF) compared with Caucasians despite having a higher prevalence of conventional risk factors for the arrhythmia. The reason for this disparity is uncertain but may be due to ethnic differences in atrial morphology. This study examines the association between ethnicity and left atrial (LA) size and function in South Asian and Caucasian subjects using the reference technique of cardiovascular magnetic resonance imaging (MRI)...
August 24, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30144122/characterization-of-hospitalized-cardiovascular-patients-with-suspected-heparin-induced-thrombocytopenia
#6
Felicitas Stoll, Miriel Gödde, Albrecht Leo, Hugo A Katus, Oliver J Müller
BACKGROUND: Little is known about heparin-induced thrombocytopenia (HIT), a pro-thrombotic, potentially life-threatening immune-mediated reaction to heparin exposure, in conservative and interventional cardiovascular medicine. HYPOTHESIS: The 4T score, validated for prediction of HIT in surgical patients before, is also suitable for assessing HIT probability in cardiovascular patients with unclear thrombocytopenia. METHODS: 403 consecutive patients from our department of cardiology, angiology and pneumology in whom a HIT screening test was performed between 2009 and 2016 were identified...
August 24, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30144121/increased-risk-of-atrial-fibrillation-in-patients-with-benign-prostatic-hypertrophy-a-population-based-cohort-study
#7
Wei-Syun Hu, Cheng-Li Lin
OBJECTIVE: The objective was to compare the rate of onset of atrial fibrillation (AF) in patients with benign prostatic hyperplasia (BPH) as compared with controls. METHODS: By using data retrieved from the ICD-9 hospitalizations coding system, we performed a retrospective study on national health registry comparing the incidence of AF between a cohort of 15670 BPH patients and a propensity-matched cohort of 15670 control patients. Univariable and multivariable Cox proportional hazards models were performed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of incident AF associated with BPH...
August 24, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30144119/glomerular-filtration-rate-a-prognostic-marker-in-atrial-fibrillation-a-sub-analysis-of-the-ata-af
#8
Riccardo Proietti, Lucio Gonzini, Giovanni Pizzimenti, Antonietta Ledda, Pietro Sanna, Ahmed AlTurki, Vincenzo Russo, Mauro Lencioni
OBJECTIVE: An increased cardiovascular mortality and morbidity has been widely reported in patients with atrial fibrillation (AF). In this study, a sub-analysis of the AntiThrombotic Agents Atrial Fibrillation (ATA-AF) is performed with the aim to evaluate estimated Glomerular Filtration Rate (eGFR) as an independent prognostic marker of cardiovascular mortality and morbidity in patients with AF METHODS AND RESULTS: The ATA-AF study enrolled 7148 patients with AF, in 360 Italian centers...
August 24, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30144116/viewpoints-in-the-diagnosis-and-treatment-of-cardiac-sarcoidosis-proposed-modification-of-current-guidelines
#9
REVIEW
Dae-Won Sohn, Jun-Bean Park, Seung-Pyo Lee, Hyung-Kwan Kim, Yong-Jin Kim
Isolated cardiac sarcoidosis is a generally accepted disease condition, and the low yield of endomyocardial biopsy because of patchy involvement is also well known. However, current guidelines still require histologic confirmation of granuloma for the diagnosis of cardiac sarcoidosis, either in myocardial or extra-cardiac tissues. Therefore, only a presumptive diagnosis of chronic multifocal myocarditis of unknown origin can be made in a large number of patients in whom the only considerable diagnosis is cardiac sarcoidosis based on current knowledge...
August 24, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30141213/the-impact-of-clinical-versus-administrative-claims-coding-on-hospital-risk-adjusted-outcomes
#10
Emily C O'Brien, Shuang Li, Laine Thomas, Tracy Y Wang, Matthew T Roe, Eric D Peterson
BACKGROUND: Comorbid condition and hospital risk-adjusted outcomes prevalence were compared based on clinical registry versus administrative claims data. METHODS: Clinical data from hospitalized CRUSADE non-ST-segment elevation myocardial infarction (NSTEMI) patients ≥65 years was linked to Medicare claims. Eight common comorbid conditions were coded and compared between registry data (derived from medical record review) and claims data; hospital-level observed versus expected ratios and outlier status for 30-day readmission and mortality were calculated using logistic generalized estimating equations for clinical versus claims data...
August 23, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30141210/predictors-of-long-term-mortality-with-cardiac-resynchronization-therapy-in-mild-heart-failure-patients-with-left-bundle-branch-block
#11
Yitschak Biton, Jason Costa, Wojciech Zareba, Jayson R Baman, Ilan Goldenberg, Scott McNitt, Scott D Solomon, Bronislava Polonsky, Valentina Kutyifa
BACKGROUND: Cardiac resynchronization therapy (CRT) is highly beneficial in patients with heart failure and left bundle branch block, however up to 30% of patients in this selected group are non-responders. HYPOTHESIS: We hypothesized that clinical and echocardiographic variables can be used to develop a simple mortality risk stratification score in CRT. METHODS: Best-subsets proportional-hazards regression analysis was used to develop a simple clinical risk score for all-cause mortality in 756 patients with left bundle branch block (LBBB) allocated to the CRT with defibrillator (CRT-D) group enrolled in the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT)...
August 23, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30141193/clinical-analysis-of-antithrombotic-treatment-and-occurrence-of-stroke-in-elderly-patients-with-non-valvular-persistent-atrial-fibrillation
#12
Lu-Jiao Yu, Shuai Chen, Yao Xu, Zi-Xin Zhang
BACKGROUND: Atrial fibrillation (AF) is common in elderly patients and is associated with ischaemic stroke. We sought to explore the current status of antithrombotic therapy in elderly patients with non-valvular persistent AF. METHODS: This is a retrospective study and data were collected from the first hospital of China Medical University. A total of 300 patients were enrolled from Jan. 2015 to Jun. 2017. Patients were divided into two groups: Group 1(from 65 to 74) and Group 2 (older than 75)...
August 23, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30125368/intravenous-regadenoson-with-aminophylline-reversal-is-safe-and-equivalent-to-intravenous-adenosine-infusion-for-fractional-flow-reserve-measurements
#13
Justin A Edward, John H Lee, Christopher J White, Daniel P Morin, Robert Bober
BACKGROUND: Small studies have shown that adenosine is equivalent to regadenoson when obtaining coronary fractional flow reserve (FFR) measurements. A study that also evaluates time and safety of aminophylline reversal of regadenoson effects has not been presented. HYPOTHESIS: Reversal of regadenoson with aminophylline is safe and equivalent to adenosine for FFR measurements. METHODS: Forty-six consecutive patients who underwent clinically indicated FFRs at the time of coronary angiography were enrolled between 4/2012 and 5/2014...
August 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30125365/the-emerging-role-of-novel-antihyperglycemic-agents-in-the-treatment-of-heart-failure-and-diabetes-a-focus-on-cardiorenal-outcomes
#14
REVIEW
Kelly R McHugh, Adam D DeVore, Robert J Mentz, Daniel Edmonston, Jennifer B Green, Adrian F Hernandez
Heart failure (HF) and type 2 diabetes mellitus (T2DM) are two global pandemics, affecting over 25 million and 420 million people, respectively. The prevalence of comorbid HF and T2DM is rising, and the prognosis remains poor. One central area of overlap of these two disease processes is renal dysfunction, which contributes to poor cardiovascular outcomes and mortality. As such, there is a growing need for antihyperglycemic agents with cardio- renoprotective effects. Three classes of novel antihyperglycemic agents, sodium-glucose cotransporter-2 (SGLT2) inhibitors, glucagon-like peptide-1 receptor agonists (GLP-1RA), and dipeptidyl peptidase-4 (DPP4) inhibitors have demonstrated varied cardiorenal outcomes in recent cardiovascular outcomes trials...
August 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30125052/assessment-of-omega-3-carboxylic-acids-in-statin-treated-patients-with-high-levels-of-triglycerides-and-low-levels-of-high-density-lipoprotein-cholesterol-rationale-and-design-of-the-strength-trial
#15
Stephen J Nicholls, A Michael Lincoff, Dianna Bash, Christie M Ballantyne, Philip J Barter, Michael H Davidson, John J P Kastelein, Wolfgang Koenig, Darren K McGuire, Dariush Mozaffarian, Terje R Pedersen, Paul M Ridker, Kausik Ray, Björn W Karlson, Torbjörn Lundström, Kathy Wolski, Steven E Nissen
BACKGROUND: It is uncertain whether omega-3 fatty acids are beneficial in statin-treated patients. Epanova is a mix of omega-3 free fatty acids, not requiring co-ingestion with food, which can lower triglycerides by up to 31%. STRENGTH will examine whether Epanova 4 g daily reduces the rate of cardiovascular events in statin-treated patients with hypertriglyceridemia and low levels of HDL-C at high risk for developing cardiovascular events. STUDY DESIGN: STRENGTH is a randomized, double-blind, placebo-controlled trial...
August 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30125047/design-and-rationale-of-the-atrial-fibrillation-occurring-transiently-with-stress-afots-follow-up-cohort-study
#16
William F McIntyre, Pablo A Mendoza, Emilie P Belley-Côté, Richard P Whitlock, Kevin J Um, Natalie Maystrenko, P J Devereaux, David Conen, Jorge A Wong, Stuart J Connolly, Jeff S Healey
BACKGROUND: Atrial fibrillation occurring transiently with stress (AFOTS) describes the first detection of AF in a patient who is hospitalized for a non-cardiac medical illness or following non-cardiac surgery. Uncertainty exists whether episodes of AFOTS are due to reversible precipitants and will not recur after recovery, or if they are paroxysmal AF that is detected during inpatient cardiac monitoring. Previous studies have used retrospective, non-systematic and ultimately low-sensitivity protocols to investigate the recurrence of AF in patients with AFOTS...
August 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30120784/clinical-and-echocardiographic-parameters-as-risk-factors-for-atrial-fibrillation-af-in-patients-with-hyperthrophic-cardiomyopathy-hcm
#17
Mariusz Klopotowski, Aleksandra Kwapiszewska, Krzysztof Kukula, Jacek Jamiolkowski, Maciej Dabrowski, Pawel Derejko, Artur Oreziak, Rafal Baranowski, Mateusz Spiewak, Magdalena Marczak, Anna Klisiewicz, Barbara Szepietowska, Zbigniew Chmielak, Adam Witkowski
BACKGROUND: Atrial fibrillation is a common complication in patients with hypertrophic cardiomyopathy (HCM) and may contribute to high cardiovascular morbidity and mortality. Therefore it is important to assess parameters associated with AF in HCM patients. OBJECTIVES: The aim of the study was to evaluate AF prevalence in patients with HCM and to investigate risk factors for AF. METHODS: 546 HCM patients age below 65 were included into analysis...
August 18, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30120772/consistent-ldl-c-response-with-evolocumab-among-patient-subgroups-in-proficio-a-pooled-analysis-of-3146-patients-from-phase-3-studies
#18
Erik Stroes, Jennifer G Robinson, Frederick J Raal, Robert Dufour, David Sullivan, Helina Kassahun, Yuhui Ma, Scott M Wasserman, Michael J Koren
BACKGROUND: Evolocumab significantly lowers low-density lipoprotein cholesterol (LDL-C) when dosed 140 mg every 2 weeks (Q2W) or 420 mg monthly (QM) subcutaneously. HYPOTHESIS: LDL-C changes are comparable among different patient subgroups in a pooled analysis of data from phase 3 trials. METHODS: A total of 3146 patients received ≥1 dose of evolocumab or control in four 12-week phase 3 studies. Percent change from baseline in LDL-C for evolocumab 140 mg Q2W or 420 mg QM vs control was reported as the average of week 10 and 12 values...
August 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30117180/right-atrial-function-by-speckle-tracking-echocardiography-in-atrial-septal-defect-prediction-of-atrial-fibrillation
#19
Antonio Vitarelli, Enrico Mangieri, Carlo Gaudio, Gaetano Tanzilli, Fabio Miraldi, Lidia Capotosto
PURPOSE: The purpose of this study was to examine right atrial (RA) function by two-dimensional (2DSTE) and three-dimensional (3DSTE) speckle-tracking echocardiography in patients with atrial septal defect (ASD) who had implantation of septal occluders and developed paroxysmal atrial fibrillation (PAF). METHODS: Seventy-three patients with hemodynamically significant secundum ASD were prospectively studied and followed up for six months after occluder insertion and compared with a normal age-matched group(n=73)...
August 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30117162/short-term-outcomes-of-pulmonary-embolism-a-national-perspective
#20
Purav Shah, Shilpkumar Arora, Varun Kumar, Surina Sharma, Harshil Shah, Byomesh Tripathi, Purnima Sharma, Ravina Sharma, Sejal Savani, Muhammad Raheel Qureshi, Ibrahim Faruqi
OBJECTIVE: Pulmonary embolism (PE) is associated with significant morbidity and mortality in hospitalized patients. Real time data on 90-day mortality, bleeding and readmission is sparse. METHODS: The study cohort was derived from the National Readmission Data (NRD) 2013-14. Pulmonary embolism was identified using International Classification of Diseases, 9th Revision (ICD-9-CM) code 415.11/3/9 in the primary diagnosis field. Any admission within 90 days of primary admission was considered a 90-day readmission...
August 17, 2018: Clinical Cardiology
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