journal
MENU ▼
Read by QxMD icon Read
search

Clinical Cardiology

journal
https://www.readbyqxmd.com/read/28333397/cardiac-device-implantations-in-obese-patients-success-rates-and-complications
#1
Philipp Attanasio, Philipp Lacour, Andrea Ernert, Burkert Pieske, Wilhelm Haverkamp, Florian Blaschke, Francesco Dalle Vedove, Martin Huemer
BACKGROUND: Obesity is associated with increased complications and potentially worse outcomes for various cardiac interventions. This study analyzed the success rate and complication rates associated with implantation of cardiac implantable electronic devices (CIEDs) in obese patients. HYPOTHESIS: Success rates are lower and complication rates higher in obese patients. METHODS: Consecutive patients undergoing CIED implantation between 2011 and 2015 in our hospital were included...
March 23, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28333373/ventricular-arrhythmias-in-patients-with-newly-diagnosed-nonischemic-cardiomyopathy-insights-from-the-prolong-study
#2
David Duncker, Thorben König, Stephan Hohmann, Johann Bauersachs, Christian Veltmann
BACKGROUND: Patients with nonischemic cardiomyopathy (NICM) reportedly have low incidence of appropriate shocks from wearable cardioverter-defibrillators (WCDs). A recent study questions the benefit from primary preventive implantation of implantable cardioverter-defibrillators in NICM. We therefore analyzed a subgroup of patients with NICM from the PROLONG study. HYPOTHESIS: Patients with newly diagnosed NICM show a risk for ventricular tachyarrhythmia. METHODS: The PROLONG study included 167 patients with newly diagnosed heart failure and left ventricular ejection fraction (LVEF) ≤35% with a WCD...
March 23, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28328015/pcsk9-inhibitor-access-barriers-issues-and-recommendations-improving-the-access-process-for-patients-clinicians-and-payers
#3
REVIEW
Seth J Baum, Peter P Toth, James A Underberg, Paul Jellinger, Joyce Ross, Katherine Wilemon
The proprotein convertase subtilisin/kexin type 9 inhibitors or monoclonal antibodies likely represent the greatest advance in lipid management in 30 years. In 2015 the US Food and Drug Administration approved both alirocumab and evolocumab for high-risk patients with familial hypercholesterolemia (FH) and clinical atherosclerotic cardiovascular disease requiring additional lowering of low-density lipoprotein cholesterol. Though many lipid specialists, cardiovascular disease prevention experts, endocrinologists, and others prescribed the drugs on label, they found their directives denied 80% to 90% of the time...
March 22, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28326559/a-phase-1-study-to-evaluate-the-safety-and-ldl-cholesterol-lowering-effects-of-rg7652-a-fully-human-monoclonal-antibody-against-proprotein-convertase-subtilisin-kexin-type-9
#4
Amos Baruch, Diana Luca, Robert S Kahn, Kyra J Cowan, Maya Leabman, Nageshwar R Budha, Cecilia P C Chiu, Yan Wu, Daniel Kirchhofer, Andrew Peterson, John C Davis, Whittemore G Tingley
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) downregulates low-density lipoprotein (LDL) receptors, thereby leading to a rise in circulating LDL cholesterol (LDL-C). RG7652 is a fully human monoclonal antibody against PCSK9. This placebo-controlled, phase 1 ascending-dose study in healthy subjects evaluated the safety of RG7652 and its efficacy as a potential LDL-C-lowering drug. HYPOTHESIS: Anti-PCSK9 antibody therapy safely and effectively reduces LDL-C...
March 22, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28323322/adaptations-following-an-intermittent-hypoxia-hyperoxia-training-in-coronary-artery-disease-patients-a-controlled-study
#5
Oleg Glazachev, Phylipp Kopylov, Davide Susta, Elena Dudnik, Elena Zagaynaya
BACKGROUND: Repeated exposure to intermittent normobaric hypoxia improves exercise tolerance in cardiac patients. Little is known on the effects of intermittent normobaric hypoxia-hyperoxia exposure in coronary artery disease (CAD) patients (New York Heart Association II-III). HYPOTHESIS: IHHT improves exercise tolerance, cardiometabolic profile, and quality of life in CAD patients. METHODS: The study design was a nonrandomized, controlled, before-and-after trial...
March 21, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28300293/coronary-artery-calcification-is-common-on-nongated-chest-computed-tomography-imaging
#6
Revathi Balakrishnan, Brian Nguyen, Roy Raad, Robert Donnino, David P Naidich, Jill E Jacobs, Harmony R Reynolds
BACKGROUND: Coronary artery calcification as assessed by computed tomography (CT) is a validated predictor of cardiovascular risk, whether identified on a dedicated cardiac study or on a routine non-gated chest CT. The prevalence of incidentally detected coronary artery calcification on non-gated chest CT imaging and consistency of reporting have not been well characterized. HYPOTHESIS: Coronary calcification is present on chest CT in some patients not taking statin therapy and may be under-reported...
March 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28300288/trends-and-outcomes-of-infective-endocarditis-in-patients-on-dialysis
#7
Nirmanmoh Bhatia, Sahil Agrawal, Aakash Garg, Divyanshu Mohananey, Abhishek Sharma, Manyoo Agarwal, Lohit Garg, Nikhil Agrawal, Amitoj Singh, Sudip Nanda, Jamshid Shirani
Dialysis patients are at high risk for infective endocarditis (IE); however, no large contemporary data exist on this issue. We examined outcomes of 44 816 patients with IE on dialysis and 202 547 patients with IE not on dialysis from the Nationwide Inpatient Sample database from 2006 thorough 2011. Dialysis patients were younger (59 ± 15 years vs 62 ± 18 years) and more likely to be female (47% vs 40%) and African-American (47% vs 40%; all P < 0.001). Hospitalizations for IE in the dialysis group increased from 175 to 222 per 10 000 patients (P trend  = 0...
March 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28300284/predictors-and-variability-of-drug-eluting-vs-bare-metal-stent-selection-in-contemporary-percutaneous-coronary-intervention-insights-from-the-prism-study
#8
Ali Shafiq, Kensey Gosch, Amit P Amin, Henry H Ting, John A Spertus, Adam C Salisbury
Drug-eluting stents (DES) reduce risk of in-stent restenosis after percutaneous coronary intervention (PCI) but require dual antiplatelet therapy (DAPT) for a longer term than bare-metal stents (BMS). Few studies have examined clinical predictors of DES vs BMS, and variability in provider selection between DES and BMS in clinical practice has not been well described. These insights can inform our understanding of current practice and may identify opportunities to improve decision-making stent selection decinsion-making...
March 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28294373/rationale-and-design-of-reduce-it-reduction-of-cardiovascular-events-with-icosapent-ethyl-intervention-trial
#9
Deepak L Bhatt, Ph Gabriel Steg, Eliot A Brinton, Terry A Jacobson, Michael Miller, Jean-Claude Tardif, Steven B Ketchum, Ralph T Doyle, Sabina A Murphy, Paresh N Soni, Rene A Braeckman, Rebecca A Juliano, Christie M Ballantyne
Residual cardiovascular risk persists despite statins, yet outcome studies of lipid-targeted therapies beyond low-density lipoprotein cholesterol (LDL-C) have not demonstrated added benefit. Triglyceride elevation is an independent risk factor for cardiovascular events. High-dose eicosapentaenoic acid (EPA) reduces triglyceride-rich lipoproteins without raising LDL-C. Omega-3s have postulated pleiotropic cardioprotective benefits beyond triglyceride-lowering. To date, no large, multinational, randomized clinical trial has proved that lowering triglycerides on top of statin therapy improves cardiovascular outcomes...
March 15, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28294370/is-there-a-prognostic-relevance-of-electrophysiological-studies-in-bundle-branch-block-patients
#10
Harilaos Bogossian, Gerrit Frommeyer, Kornelius Göbbert, Fuad Hasan, Quy Suu Nguyen, Ilias Ninios, Dejan Mijic, Dirk Bandorski, Reinhard Hoeltgen, Melchior Seyfarth, Bernd Lemke, Lars Eckardt, Markus Zarse
BACKGROUND: The present European guidelines suggest a diagnostic electrophysiological (EP) study to determine indication for cardiac pacing in patients with bundle branch block and unexplained syncope. We evaluated the prognostic relevance of an EP study for mortality and the development of permanent complete atrioventricular (AV) block in patients with symptomatic bifascicular block and first-degree AV block. HYPOTHESIS: The HV interval is a poor prognostic marker to predict the development of permanent AV block in patients with symptomatic bifascicular block (BFB) and AV block I°...
March 15, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28295398/echocardiographic-evaluation-of-the-right-ventricle-clinical-implications
#11
REVIEW
Tanya Dutta, Wilbert S Aronow
Interest in evaluation of the right ventricle (RV) has increased recently. With the growth of new echocardiographic techniques and technology, there has been a corresponding increase in the ability to evaluate the RV, both qualitatively and quantitatively. Older echocardiographic techniques, such as right ventricular fractional area of change, tricuspid annular plane systolic excursion, and tissue S', and newer echocardiographic techniques including 3-dimensional evaluation and global longitudinal strain, can improve our evaluation of RV function...
March 14, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28295387/short-and-long-term-clinical-predictors-of-pharmacological-cardioversion-of-persistent-atrial-fibrillation-by-dofetilide-a-retrospective-cohort-study-of-160-patients
#12
Hafeez Ul Hassan Virk, Waqas T Qureshi, Nayani Makkar, Joseph Bastawrose, Nektarios Souvaliotis, Joshua Aziz, Emad Aziz
INTRODUCTION: Dofetilide is a class III antiarrhythmic prescribed to cardiovert persistent atrial fibrillation (AF) to sinus rhythm (SR). HYPOTHESIS: To determine the clinical predictors of cardioversion and readmission in persistent AF patients on dofetilide. METHODS: We analyzed 160 patients with persistent AF who were started on dofetilide and followed for 1 year. We examined age, sex, race, hypertension, diabetes, smoking, dyslipidemia, CAD, left ventricular ejection fraction (LVEF), creatinine, BMI and concomitant use of calcium channel blockers (CCB), β-blockers in a multivariable logistic regression model...
March 14, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28294364/predictors-and-long-term-outcome-of-super-responders-to-cardiac-resynchronization-therapy
#13
Abdul Ghani, Peter Paul H M Delnoy, Ahmet Adiyaman, Jan Paul Ottervanger, Anand R Ramdat Misier, Jaap Jan J Smit, Arif Elvan
BACKGROUND: The level of improvement in left ventricular ejection fraction (LVEF) in super-responders to cardiac resynchronization therapy (CRT) is exceptional. However, the long-term prognosis remains unknown in a large population. HYPOTHESIS: Whether super-responders haven good long-term outcomes. METHODS: We registered 347 patients with primary CRT-D indication. Super-response was defined by LVEF >50% at follow-up echocardiogram. Best-subset regression analysis identified predictors of super-response...
March 14, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28295468/the-protective-effects-of-a-novel-fitness-fatness-index-on-all-cause-mortality-among-adults-with-cardiovascular-disease
#14
Emily Frith, Paul D Loprinzi
BACKGROUND: We evaluated the specific association between a fitness-fatness index (FFI) and all-cause mortality among a national sample of US adults with coronary artery disease, congestive heart failure, or myocardial infarction. This FFI has recently emerged in the literature as a novel index of health. HYPOTHESIS: We hypothesize that FFI will be inversely associated with mortality risk. METHODS: The FFI was calculated as cardiorespiratory fitness divided by waist-to-height ratio...
March 10, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28295435/the-role-of-thyroid-hormones-in-acute-coronary-syndromes-prognostic-value-of-alterations-in-thyroid-hormones
#15
REVIEW
Vasileios Lamprou, Dimitrios Varvarousis, Kali Polytarchou, Giolanda Varvarousi, Theodoros Xanthos
The prognosis of acute coronary syndromes (ACS) is affected by many factors. Normal thyroid homeostasis is known to alter during various critical illnesses, a condition that has been shown to correlate with the severity of the disease and increased mortality. The purpose of this article is to review literature to emphasize the considerable association of thyroid function with the cardiovascular system and summarize all existing evidence with regard to the role of thyroid hormones alterations during ACS. The electronic databases of PubMed, Medline, Scopus, and Cochrane were searched for relevant literature and studies...
March 10, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28295429/urinary-timp-2-%C3%A2-%C3%A3-%C3%A2-igfbp7-for-risk-prediction-of-acute-kidney-injury-in-decompensated-heart-failure
#16
Moritz Schanz, Jing Shi, Christoph Wasser, Mark Dominik Alscher, Martin Kimmel
BACKGROUND: In acute decompensated heart failure (ADHF) the risk of acute kidney injury (AKI) is high. Early detection of patients at risk for AKI is important. We tested urinary [TIMP-2] × [IGFBP7], a new US Food and Drug Administration-cleared test to assess AKI risk, in a cohort of hospitalized ADHF patients. HYPOTHESIS: In patients with ADHF, urinary [TIMP-2] × [IGFBP7] is associated with moderate to severe AKI and related to increased mortality. METHODS: We enrolled 400 patients in the emergency department at Robert-Bosch Hospital, Stuttgart, Germany...
March 10, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28294372/alcohol-and-cardiovascular-disease-in-the-geriatric-population
#17
REVIEW
Aditi Kalla, Vincent M Figueredo
There has been little focus on the effects of alcohol on the elderly. Although the cardiovascular benefits of moderate alcohol consumption could be of the greatest benefit in this group, so might be the detrimental effects of abuse. In this article, we review available data on the effects of alcohol consumption on cardiovascular disease, cardiomyopathy, arrhythmias, hypertension, and vascular function in older adults. Alcohol consumption has increased in the US population age 65 years and older in the last decade, as has monthly heavy episodic drinking in older alcohol consumers...
March 10, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28294356/prevalence-and-clinical-significance-of-left-bundle-branch-block-according-to-classical-or-strict-definition-criteria-in-permanent-pacemaker-patients
#18
Andrea Mazza, Maria Grazia Bendini, Raffaele De Cristofaro, Mariolina Lovecchio, Sergio Valsecchi, Massimo Leggio, Giuseppe Boriani
BACKGROUND: Previous studies have shown that the presence of left bundle branch block (LBBB) is associated with an increased risk of cardiac mortality and heart failure (HF). Recently, new criteria to define strict LBBB have been proposed: QRS duration ≥140 ms for men and ≥130 ms for women, along with mid-QRS notching or slurring in ≥2 contiguous leads. HYPOTHESIS: We assessed the prevalence and prognostic significance of LBBB according to classical (QRS duration ≥120ms) and strict criteria in permanent pacemaker patients...
March 10, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28273405/heart-rhythm-society-expert-consensus-statements-part-2
#19
REVIEW
Susie Sennhauser, Rishi Anand, Fred Kusumoto, Nora Goldschlager
One of the most important roles for professional societies in medicine is assembling multiple stakeholders and experts to develop documents that can help guide and define policies and strategies for best medical care. Each year the Heart Rhythm Society (HRS) develops several consensus documents that address critical clinical subjects that have been identified by input from HRS members and HRS committees. Over the past 5 years, HRS has produced documents with multiple professional societies from around the world, and although the topics chosen for exploration center around arrhythmia management, the reviews and recommendations made in the documents are important for clinical cardiologists and generalists who are not arrhythmia specialists...
March 8, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28273368/silent-atrial-fibrillation-epidemiology-diagnosis-and-clinical-impact
#20
REVIEW
Polychronis E Dilaveris, Harold L Kennedy
Silent or subclinical asymptomatic atrial fibrillation (SAF) has currently gained wide interest in the epidemiologic, neurologic, and cardiovascular communities. It is well known that the electrophysiological and mechanical effects of symptomatic and silent atrial fibrillation (AF) are the same. It is probable that because "AF begets AF," progression from paroxysmal to persistent or permanent AF might be more rapid in patients with long-term unrecognized and untreated SAF, because no treatment is sought by or provided to such patients...
March 8, 2017: Clinical Cardiology
journal
journal
27597
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"