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Clinical Cardiology

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https://www.readbyqxmd.com/read/28817194/prediction-and-prognosis-of-ventricular-tachycardia-recurrence-after-catheter-ablation-with-remote-magnetic-navigation-for-electrical-storm-in-patients-with-ischemic-cardiomyopathy
#1
Qi Jin, Peter Karl Jacobsen, Steen Pehrson, Xu Chen
BACKGROUND: Ventricular tachycardia (VT) recurrence after catheter ablation for electrical storm is commonly seen in patients with ischemic cardiomyopathy (ICM). HYPOTHESIS: We hypothesized that VT recurrence can be predicted and be related to the all-cause death after VT storm ablation guided by remote magnetic navigation (RMN) in patients with ICM. METHODS: A total of 54 ICM patients (87% male; mean age, 65 ± 7.1 years) presenting with VT storm undergoing acute ablation using RMN were enrolled...
August 17, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28805969/study-of-young-patients-with-myocardial-infarction-design-and-rationale-of-the-young-mi-registry
#2
Avinainder Singh, Bradley Collins, Arman Qamar, Ankur Gupta, Amber Fatima, Sanjay Divakaran, Josh Klein, Jon Hainer, Petr Jarolim, Ravi V Shah, Khurram Nasir, Marcelo F Di Carli, Deepak L Bhatt, Ron Blankstein
The YOUNG-MI registry is a retrospective study examining a cohort of young adults age ≤ 50 years with a first-time myocardial infarction. The study will use the robust electronic health records of 2 large academic medical centers, as well as detailed chart review of all patients, to generate high-quality longitudinal data regarding the clinical characteristics, management, and outcomes of patients who experience a myocardial infarction at a young age. Our findings will provide important insights regarding prevention, risk stratification, treatment, and outcomes of cardiovascular disease in this understudied population, as well as identify disparities which, if addressed, can lead to further improvement in patient outcomes...
August 14, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28805967/prognostic-value-of-exercise-capacity-among-men-undergoing-pharmacologic-treatment-for-erectile-dysfunction-the-fit-project
#3
Robert V Same, Mahmoud Al Rifai, David I Feldman, Kevin L Billups, Clinton A Brawner, Zeina A Dardari, Jonathan K Ehrman, Steven J Keteyian, Mouaz H Al-Mallah, Michael J Blaha
BACKGROUND: Vascular erectile dysfunction (ED) has been identified as a potentially useful risk factor for predicting future cardiovascular events, particularly in younger men. Because these men typically score more favorably on traditional cardiovascular disease risk assessment tools, there exists a gap in knowledge for how to most appropriately identify those men who would benefit from more aggressive treatments. To date, no studies have examined the impact of fitness on cardiovascular outcomes in men with ED...
August 14, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28805957/stroke-or-left-atrial-thrombus-prediction-using-antithrombin-iii-and-mean-platelet-volume-in-patients-with-nonvalvular-atrial-fibrillation
#4
Seo-Won Choi, Bo-Bae Kim, Dong-Hyun Choi, Geon Park, Byung Chul Shin, Heesang Song, DongHun Kim, Dong-Min Kim
BACKGROUND: CHADS2 (congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke) and CHA2 DS2 -VASc (congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke, vascular disease, age 65 to 74 years, sex category) scores showed just moderate discrimination ability in predicting thromboembolic complications in patients with nonvalvular atrial fibrillation (AF). HYPOTHESIS: To determine the association of antithrombin III (AT-III) deficiency and mean platelet volume (MPV) with the development of stroke or left atrial (LA) thrombus in patients with AF...
August 14, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28800149/atrial-fibrillation-variability-on-long-term-monitoring-of-implantable-cardiac-rhythm-management-devices
#5
Rachel M Kaplan, Paul D Ziegler, Jodi Koehler, Taya V Glotzer, Rod S Passman
BACKGROUND: Atrial fibrillation (AF) burden and duration are predictors of thromboembolic events. The random nature of these measures may affect clinical decision making. The objective of this study was to determine temporal changes in AF burden as detected by continuous monitoring. HYPOTHESIS: AF burden changes over time when detected by continuous monitoring. METHODS: A post hoc analysis of patients enrolled in the TRENDS (A Prospective Study of the Clinical Significance of Atrial Arrhythmias Detected by Implanted Device Diagnostics) study with ≥1 stroke risk factor(s) who were implanted with a dual-chamber cardiac rhythm management device (CRMD) and had AF burden data available for ≥2 years was performed...
August 11, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28750156/psychiatric-conditions-as-predictors-of-rehospitalization-among-african-american-patients-hospitalized-with-heart-failure
#6
Marvin Louis Roy Lu, Toni Anne De Venecia, Abhinav Goyal, Mary Rodriguez Ziccardi, Napatt Kanjanahattakij, Mahek Kishor Shah, Carlos D Davila, Vincent M Figueredo
INTRODUCTION: African Americans (AAs) have the highest risk of developing heart failure (HF) among all ethnicities in the United States and are associated with higher rates of readmissions and mortality. This study aims to determine the prevalence and relationship of common psychiatric conditions to outcomes of patients hospitalized with HF. HYPOTHESIS: Psychiatric conditions lead to worse outcomes in HF patients. METHODS: This single-center retrospective study enrolled 611 AA patients admitted to an urban teaching community hospital for HF from 2010 to 2013...
July 27, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28750152/left-atrial-appendage-occlusion-for-stroke-prevention-in-patients-with-atrial-fibrillation
#7
REVIEW
Rizma Jalees Bajwa, Lara Kovell, Jon R Resar, Armin Arbab-Zadeh, Kaushik Mandal, Hugh Calkins, Ronald D Berger
Atrial fibrillation (AF) is a commonly sustained atrial arrhythmia with associated morbidity and mortality. AF is associated with increased risk of thromboembolism and stroke, requiring use of anticoagulation. Anticoagulation decreases the risk of stroke but is associated with a higher risk of bleeding, necessitating discontinuation in some patients. The left atrial appendage is the likely source of thrombus in the majority of patients with AF. This has led to the development of left atrial appendage occlusion as a means to reduce stroke risk in patients who have a contraindication to long-term anticoagulation...
July 27, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28741314/the-2017-american-society-for-preventive-cardiology-congress-and-experts-course
#8
EDITORIAL
Seth J Baum
No abstract text is available yet for this article.
July 24, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28741295/early-segmental-relaxation-abnormalities-in-hypertrophic-cardiomyopathy-for-differential-diagnostic-of-patients-with-left-ventricular-hypertrophy
#9
Christian Voigt, Julia Münch, Maxim Avanesov, Anna Suling, Katrin Witzel, Gunnar Lund, Monica Patten
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left ventricular hypertrophy (LVH). However, clinical signs can be subtle and differentiation from other causes of LVH is challenging. HYPOTHESIS: As diastolic dysfunction (DD) is an early sign in HCM, we aimed to find regional changes in relaxation pattern for differentiation from other entities of LVH. METHODS: In 148 patients (81 HCM, 55 arterial hypertension (AHT), 12 Fabry disease) and 63 healthy controls, relaxation patterns were assessed using regional tissue Doppler imaging...
July 24, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28724192/handheld-echocardiography-during-hospitalization-for-acute-myocardial-infarction
#10
Michael W Cullen, Jeffrey B Geske, Nandan S Anavekar, J Wells Askew, Bradley R Lewis, Jae K Oh
BACKGROUND: Handheld echocardiography (HHE) is concordant with standard transthoracic echocardiography (TTE) in a variety of settings but has not been thoroughly compared to traditional TTE in patients with acute myocardial infarction (AMI). HYPOTHESIS: Completed by experienced operators, HHE provides accurate diagnostic capabilities compared with standard TTE in AMI patients. METHODS: This study prospectively enrolled patients admitted to the coronary care unit with AMI...
July 19, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28712144/frailty-is-an-independent-prognostic-marker-in-elderly-patients-with-myocardial-infarction
#11
Gonzalo Luis Alonso Salinas, Marcelo Sanmartin, Marina Pascual Izco, Luis Miguel Rincon, Pablo Pastor Pueyo, Alvaro Marco Del Castillo, Alberto Garcia Guerrero, Pedro Caravaca Perez, Alejandro Recio-Mayoral, Asuncion Camino, Manuel Jimenez-Mena, José Luis Zamorano
BACKGROUND: Acute coronary syndrome (ACS) patients are increasingly older. Conventional prognostic scales include chronological age but do not consider vulnerability. In elderly patients, a frail phenotype represents a better reflection of biological age. HYPOTHESIS: This study aims to determine the prevalence of frailty and its influence on patients age ≥75 years with ACS. METHODS: Patients age ≥75 years admitted due to type 1 myocardial infarction were included in 2 tertiary hospitals, and clinical data were collected prospectively...
July 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28703931/rationale-and-design-of-a-randomized-trial-of-apixaban-vs-warfarin-to-evaluate-atherosclerotic-calcification-and-vulnerable-plaque-progression
#12
Kazuhiro Osawa, Rine Nakanishi, Theingi Tiffany Win, Dong Li, Sina Rahmani, Negin Nezarat, Nasim Sheidaee, Matthew J Budoff
Vitamin K antagonists (VKAs) are known to increase vascular calcification, suggesting increased cardiovascular disease events. Apixaban is an oral direct factor Xa inhibitor superior to warfarin at preventing stroke or systemic embolism and may stabilize coronary atherosclerosis. The potential benefits of avoiding VKA therapy and the favorable effects of factor Xa inhibitors could contribute to cardiovascular disease event reduction. We hypothesized that apixaban inhibits vascular calcification and coronary atherosclerosis progression compared with warfarin in patients with atrial fibrillation (AF)...
July 13, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28696578/does-education-modify-the-effect-of-ethnicity-in-the-expression-of-ideal-cardiovascular-health-the-baptist-health-south-florida-employee-study
#13
Oluseye Ogunmoroti, Ovie A Utuama, Erin D Michos, Javier Valero-Elizondo, Victor Okunrintemi, Ziyad Ben Taleb, Raed Bahelah, Sankalp Das, Maribeth Rouseff, Don Parris, Arthur Agatston, Theodore Feldman, Emir Veledar, Wasim Maziak, Khurram Nasir
BACKGROUND: Despite the progress made to decrease risk factors for cardiovascular diseases, disparities still exist. We examined how education and ethnicity interact to determine disparities in cardiovascular health (CVH) as defined by the American Heart Association. HYPOTHESIS: Education modifies the effect of ethnicity on CVH. METHODS: Individual CVH metrics (smoking, physical activity, body mass index, diet, total cholesterol, blood pressure, and blood glucose) were defined as ideal, intermediate, or poor...
July 11, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28696573/prognostic-implications-of-q-waves-at-presentation-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention-an-analysis-of-the-horizons-ami-study
#14
Ioanna Kosmidou, Björn Redfors, Aaron Crowley, Bernard Gersh, Shmuel Chen, José M Dizon, Monica Embacher, Roxana Mehran, Ori Ben-Yehuda, Gary S Mintz, Gregg W Stone
BACKGROUND: Presence of Q waves on the presenting electrocardiogram (ECG) in patients with ST-segment elevation myocardial infarction (STEMI) has been associated with worse prognosis; however, whether the prognostic value of Q waves is influenced by baseline characteristics and/or rapidity of revascularization based on the guideline-based metric of door-to-balloon time remains unknown. HYPOTHESIS: We hypothesized that Q waves in the presenting ECG will be predictive of long term mortality regardless of time to reperfusion...
July 11, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28692760/current-trends-in-admissions-and-outcomes-of-cardiac-diseases-in-ghana
#15
Lambert T Appiah, Fred S Sarfo, Charles Agyemang, Humphrey O Tweneboah, Nana Akua B A Appiah, George Bedu-Addo, Ohene Opare-Sem
Cardiovascular diseases (CVDs) pose a major burden in Africa, but data on temporal trends in disease burden are lacking. We assessed trends in CVD admissions and outcomes in central Ghana using a retrospective analysis of data from January 2004 to December 2015 among patients admitted to the medical wards of a tertiary medical center in Kumasi, Ghana. Rates of admissions and mortality were expressed as CVD admissions and deaths divided by the total number of medical admissions and deaths, respectively. Case fatality rates per specific cardiac disease diagnosis were also computed...
July 10, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28692753/decreased-pulmonary-arterial-proportional-pulse-pressure-is-associated-with-increased-mortality-in-group-1-pulmonary-hypertension
#16
Hunter Mwansa, Kenneth C Bilchick, Alex M Parker, William Harding, Benjamin Ruth, Jamie L W Kennedy, Manu Mysore, Younghoon Kwon, Andrew Mihalek, Sula Mazimba
BACKGROUND: This study evaluated the utility of a novel index, pulmonary arterial (PA) proportional pulse pressure (PAPP; range 0-1, defined as [PA systolic pressure - PA diastolic pressure] / PA systolic pressure), in predicting mortality in patients with World Health Organization group 1 pulmonary hypertension (PH). HYPOTHESIS: Low PAPP is associated with increased 5-year mortality independent of a validated contemporary risk-prediction equation (Pulmonary Hypertension Connection [PHC] equation)...
July 10, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28692742/vitamin-k-antagonists-with-or-without-long-term-antiplatelet-therapy-in-outpatients-with-stable-coronary-artery-disease-and-atrial-fibrillation-association-with-ischemic-and-bleeding-events
#17
Gilles Lemesle, Gregory Ducrocq, Yedid Elbez, Eric Van Belle, Shinya Goto, Christopher P Cannon, Christophe Bauters, Deepak L Bhatt, Philippe Gabriel Steg
BACKGROUND: It remains uncertain whether patients with atrial fibrillation (AF) requiring long-term oral anticoagulation (OAC) and with stable coronary artery disease (CAD) should receive antiplatelet therapy (APT) in addition to OAC. HYPOTHESIS: APT in addition to OAC would be more effective than OAC alone in preventing ischaemic events in such patients. METHODS: In the international REduction of Atherothrombosis for Continued Health (REACH) Registry including 68 236 outpatients with or at risk for atherothrombosis, we identified 2347 patients with stable CAD and AF receiving vitamin K antagonists (VKA)...
July 10, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28692741/pulmonary-embolism-in-a-morbidly-obese-patient-receiving-dabigatran
#18
LETTER
Usama Nasir
No abstract text is available yet for this article.
July 10, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28683177/determination-of-ideal-target-exercise-heart-rate-for-cardiac-patients-suitable-for-rehabilitation
#19
Shih Jia Janice Tan, John Carson Allen, Swee Yaw Tan
BACKGROUND: Exercise prescription for patients with cardiovascular disease remains a challenge. The concept of exercising at an intensity equivalent to one's anaerobic threshold has been well studied and highly recommended in the fitness industry for other populations. For this concept to be applicable to patients with cardiovascular disease, the level and intensity of activity must not trigger myocardial ischemia. HYPOTHESIS: We hypothesized that the heart rate at ventilatory anaerobic threshold (HRVAT ) will not exceed heart rate at ischemic threshold (HRIT ) (ie, HRVAT ≤ HRIT in a majority [>50%] of patients)...
July 6, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28683175/cost-effectiveness-analysis-of-30-month-vs-12-month-dual-antiplatelet-therapy-with-clopidogrel-and-aspirin-after-drug-eluting-stents-in-patients-with-acute-coronary-syndrome
#20
Minghuan Jiang, Joyce H S You
Continuation of dual antiplatelet therapy (DAPT) beyond 1 year reduces late stent thrombosis and ischemic events after drug-eluting stents (DES) but increases risk of bleeding. We hypothesized that extending DAPT from 12 months to 30 months in patients with acute coronary syndrome (ACS) after DES is cost-effective. A lifelong decision-analytic model was designed to simulate 2 antiplatelet strategies in event-free ACS patients who had completed 12-month DAPT after DES: aspirin monotherapy (75-162 mg daily) and continuation of DAPT (clopidogrel 75 mg daily plus aspirin 75-162 mg daily) for 18 months...
July 6, 2017: Clinical Cardiology
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