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Clinical Cardiology

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https://www.readbyqxmd.com/read/29998519/reply-to-low-prevalence-of-diabetes-with-chronic-complications-in-patients-with-takotsubo-syndrome
#1
LETTER
Rupak Desai, Sandeep Singh, Hemant Goyal, Abhijeet Dhoble, Abhishek Deshmukh, Gautam Kumar, Rajesh Sachdeva
We thank Dr. Madias for his interest in our manuscript regarding the impact of obesity on the in-hospital outcomes in takotsubo cardiomyopathy (TCM) patients.1 In Table 2 of our paper, we compared the frequency of comorbidities in non-obese vs. obese TCM patients. We found a higher frequency of diabetes mellitus (DM) including both uncomplicated (37.2% vs 15.3%) and complicated (4.5% vs 1.9%) cases in the obese-TCM cohort. This article is protected by copyright. All rights reserved.
July 11, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29992581/low-prevalence-of-diabetes-with-chronic-complications-in-patients-with-takotsubo-syndrome
#2
LETTER
John E Madias
Desai et al1 reported on their explorations whether obesity affects the in-hospital outcomes of patients who have suffered takotsubo syndrome (TTS), employing 612 obese TTS (weighted N=3034) and 5696 non-obese TCM (weighted N=28,186) patients in propensity-score matched cohorts, from the National Inpatient Sample database from 2010-2014. Although there were no significant differences in all-cause mortality, arrhythmias, length of hospital stay, and total hospital charges, between the two groups, cardiac complications, such as acute myocardial infarction, cardiac arrest, cardiogenic shock, congestive heart failure, use of mechanical hemodynamic support (Impella®), and respiratory failure, were significantly higher among obese patients with TTS, as compared to non-obese patients with TTS...
July 11, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29974493/the-incremental-predictive-value-of-frailty-measures-in-elderly-patients-undergoing-cardiac-surgery-a-systematic-review
#3
REVIEW
Zhe Li, Xin Ding
BACKGROUND: Emerging evidence demonstrate that frailty measures can predict adverse outcomes after cardiac procedures. Our objective was to examine whether the inclusion of frailty measures adds incremental predictive value on existing surgical risk prediction models in patients undergoing cardiac surgery, and evaluate the reporting and methods of studies that investigated the prediction of frailty measures in cardiology. HYPOTHESIS: The inclusion of frailty measures adds incremental predictive value on existing perioperative risk scoring systems...
July 5, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29968356/atrial-fibrillation-in-an-african-american-cohort-the-jackson-heart-study
#4
Thomas R Austin, Kerri L Wiggins, Chad Blackshear, Yi Yang, Emelia J Benjamin, Lesley H Curtis, Nona Sotoodehnia, Adolfo Correa, Susan R Heckbert
BACKGROUND: Atrial fibrillation (AF) is an important public health problem across race/ethnic groups. Data from US cohort studies initiated in the 1980s suggest higher prevalence of AF risk factors among African Americans (AAs) than whites, but lower AF incidence. The Jackson Heart Study (JHS) is a community-based study of 5,306 AAs recruited starting in 2000. HYPOTHESIS: Demographic, anthropometric, cardiovascular, and/or electrocardiographic factors are associated with AF incidence in JHS...
July 2, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29962050/rationale-and-design-of-a-randomized-study-to-assess-the-efficacy-and-safety-of-evolocumab-in-patients-with-diabetes-and-dyslipidemia-the-berson-clinical-trial
#5
Alberto J Lorenzatti, Freddy G Eliaschewitz, Yundai Chen, Jonathan Fialkow, Juming Lu, Alexis Baass, Maria Laura Monsalvo, Hui-Chun Hsu, Ransi Somaratne, Junbo Ge
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major independent risk factor for cardiovascular disease, and diabetic dyslipidemia is a major contributor to cardiovascular risk in these patients. Here we report the rationale and design of a phase 3, double-blind study specifically designed to evaluate the lipid-lowering efficacy of the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor evolocumab in patients with T2DM and hyperlipidemia or mixed dyslipidemia who are on background statin therapy...
July 1, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29959806/severe-bradyarrhythmia-linked-to-left-atrial-dysfunction-in-fabry-disease-a-cross-sectional-study-cross-sectional-analysis-of-the-clinical-electrocardiographic-and-echocardiographic-determinants-of-bradyarrhythmic-events-in-patients-with-fabry-disease-the-impact
#6
Lu Zhao Di, Maxime Pichette, Réginald Nadeau, Daniel G Bichet, Frédéric Poulin
BACKGROUND: Fabry disease (FD) is a lysosomal storage disorder caused by an enzymatic deficiency. Conduction abnormalities and bradyarrhythmias are common and can occur prior to the onset of left ventricular (LV) hypertrophy. We aimed to describe the clinical, electrocardiographic and echocardiographic, including left atrial (LA) function, determinants of bradyarrhythmic events in FD. METHODS: We designed a cross-sectional study that includes 53 FD patients (mean age, 45 years; 42% male)...
June 30, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29952015/c-reactive-protein-during-and-after-myocardial-infarction-in-relation-to-cardiac-injury-and-left-ventricular-function-at-follow-up
#7
Maarten Vanhaverbeke, Denise Veltman, Nele Pattyn, Nico De Crem, Hilde Gillijns, Véronique Cornelissen, Stefan Janssens, Peter R Sinnaeve
BACKGROUND: Acute myocardial infarction (MI) invokes a large inflammatory response which contributes to myocardial repair. HYPOTHESIS: We investigated whether C-reactive protein (CRP) measured during MI versus at 1 month follow-up improves the prediction of left ventricular (LV) function. METHODS: We prospectively enrolled 131 consecutive patients with acute myocardial infarction and without non-cardiovascular causes of inflammation. We correlated admission and peak levels of CRP during hospitalization and high-sensitivity (hs) CRP at 1 month follow-up with markers of cardiac injury...
June 27, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29934991/the-role-and-outcome-of-cardiac-rehabilitation-program-in-patients-with-atrial-fibrillation
#8
Arwa Younis, Ella Shaviv, Eyal Nof, Ariel Israel, Anat Berkovitch, Ilan Goldenberg, Michael Glikson, Robert Klempfner, Roy Beinart
BACKGROUND: Atrial fibrillation (AF) is associated with diminished cardiac function, and exercise tolerance. HYPOTHESIS: We sought to investigate the role of cardiac rehabilitation program (CR) in patients with AF. METHODS: The study included 2165 consecutive patients that participated in our CR program between the years 2009 - 2015. All were evaluated by a standard exercise stress test (EST) at baseline, and upon completion of at least 3 months of training...
June 23, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29934948/impact-of-pacemaker-longevity-on-expected-device-replacement-rates-results-from-computer-simulations-based-on-a-multicenter-registry-essential
#9
Giuseppe Boriani, Matteo Bertini, Davide Saporito, Giuseppina Belotti, Fabio Quartieri, Corrado Tomasi, Angelo Pucci, Giulio Boggian, Gian Franco Mazzocca, Davide Giorgi, Paolo Diotallevi, Biagio Sassone, Diego Grassini, Alessio Gargaro, Mauro Biffi
AIMS: We estimated the probability of device replacement in an unselected population of pacemaker recipients, with automatic management of atrial and ventricular pacing output. METHODS: We considered a cohort of 542 pacemaker patients (age 78±9 years, 60% male, 71% de-novo implants) and combined 1-month projected device longevity with survival data and late complication rate in a 3-state Markov model tested in several Monte Carlo computer simulations. Predetermined subgroups were: age < or ≥ 70; gender; primary indication to cardiac pacing...
June 23, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29934946/the-de-winter-electrocardiogram-pattern-is-a-transient-electrocardiographic-phenomenon-that-presents-at-the-early-stage-of-st-segment-elevation-myocardial-infarction
#10
Aihua Wang, Jing Xu, Li Liu, Zijun Chen
BACKGROUND: The de Winter electrocardiogram (EKG) pattern is a novel sign that indicates left anterior descending coronary artery (LAD) occlusion in patients with chest pain. This study aimed to assess the prevalence and clinical characteristics of patients with this pattern. HYPOTHESIS: The de Winte EKG pattern is an special anterior ST-segment elevation myocardial infarction(STEMI) equivalents without obvious ST-segment elevation. METHODS: This retrospective study included all patients with anterior myocardial infarction admitted between January 2011 and December 2017...
June 23, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29920728/rate-related-left-bundle-branch-block-and-cardiac-memory-in-a-patient-with-bradycardia-case-report-and-literature-review
#11
REVIEW
Luke Seibolt, Camila Maestas, Mohamad Lazkani, Umaima Fatima, Akil Loli, Michael Chesser
BACKGROUND: Rate-related left bundle branch block (LBBB) is a well-studied phenomenon. Cardiac memory is another physiologic phenomenon in which T-wave abnormalities occur in the absence of ischemia. The association between these two phenomena has been described in several case reports. METHODS: A literature review was performed through OVID and Pubmed, where at total of 93 cases of rate- related LBBB were identified. Cases were reviewed and data were collected on rates of appearance and disappearance as well as the presence or absence of cardiac memory...
June 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29920711/the-art-of-cardiovascular-risk-assessment
#12
LETTER
Jay Khambhati, Marc Allard-Ratick, Devinder Dhindsa, Suegene Lee, John Chen, Pratik B Sandesara, Arshed A Quyyumi, Nathan D Wong, Roger S Blumenthal, Laurence Sperling
The authors would like to submit two corrections on the recently published manuscript, Art of Cardiovascular Risk Assessment. In section 4, the original sentence states: "However, the SCCT does not recommend use of a CAC score in low-risk patients with an ASCVD risk of < 10%." We would like to correct this to "Furthermore, the SCCT recommends consideration of a CAC score in those with a risk score of 5-20% and selectively in those with lower predicted risk who have a family history of premature ASCVD or other risk conditions...
June 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29920702/false-positive-stress-testing-does-endothelial-vascular-dysfunction-contribute-to-st-segment-depression-in-women-a-pilot-study
#13
Shilpa Sharma, Puja K Mehta, Reza Arsanjani, Tara Sedlak, Zachary Hobel, Chrisandra Shufelt, Erika Jones, Paul Kligfield, David Mortara, Michael Laks, Marcio Diniz, C Noel Bairey Merz
BACKGROUND: The utility of exercise-induced ST-segment depression for diagnosing ischemic heart disease (IHD) in women is unclear. HYPOTHESIS: Based on evidence that IHD pathophysiology in women involves coronary vascular dysfunction, we hypothesized that coronary vascular dysfunction contributes to exercise electrocardiography (Ex-ECG) ST-depression in the absence of obstructive CAD, so-called "false positive" results. We tested our hypothesis in a pilot study evaluating the relationship between peripheral vascular endothelial function and Ex-ECG...
June 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29917260/does-obesity-affect-the-outcomes-in-takotsubo-cardiomyopathy-analysis-of-the-nationwide-inpatient-sample-database-2010-2014
#14
Rupak Desai, Sandeep Singh, Maryam Baikpour, Hemant Goyal, Abhijeet Dhoble, Abhishek Deshmukh, Gautam Kumar, Rajesh Sachdeva
BACKGROUND: It is well known that obesity can lead to increased oxidative stress, which is one of the proposed mechanisms in the etiopathogenesis of Takotsubo Cardiomyopathy (TCM). However, it is unknown if the presence of obesity affects the outcomes in patients with TCM. METHODS: We queried the National Inpatient Sample database from 2010-2014 to identify adult patients who admitted with a principal diagnosis of TCM with and without obesity. We compared the categorical and continuous variables by Pearson's chi-square and Student's t-test respectively in propensity-score matched cohorts...
June 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29896874/is-self-rated-health-associated-with-ideal-cardiovascular-health-the-multi-ethnic-study-of-atherosclerosis
#15
Olatokunbo Osibogun, Oluseye Ogunmoroti, Erica S Spatz, Gregory L Burke, Erin D Michos
BACKGROUND: Self-rated health (SRH) is an indicator of health status. It is a determinant of health-promoting behaviors and predictor of morbidity and mortality. Yet, little is known about the association between SRH and ideal cardiovascular health (CVH) as measured by the American Heart Association Life's Simple Seven (LS7) metrics, or whether the relation of SRH and CVH differ by race/ethnicity. HYPOTHESIS: Favorable SRH is associated with better CVH. METHODS: We conducted a cross-sectional analysis of 6457 men and women of 4 race/ethnicities who participated in the Multi-Ethnic Study of Atherosclerosis...
June 12, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29896861/galectin-3-and-st2-as-predictors-of-therapeutic-success-in-high-risk-patients-undergoing-percutaneous-mitral-valve-repair-mitraclip
#16
Oliver Dörr, Claudia Walther, Christoph Liebetrau, Till Keller, Thomas Sommer, Niklas Boeder, Matthias Bayer, Pascal Bauer, Helge Möllmann, Luise Gaede, Christian Troidl, Sandra Voss, Timm Bauer, Christian W Hamm, Holger Nef
BACKGROUND: Percutaneous mitral valve repair (PMVR) is an interventional treatment option in patients with severe mitral regurgitation (MR) who have a high risk for open-heart surgery. Currently, there is limited information about predictors of procedural success after PMVR. Galectin-3 (Gal-3) and ST2 induce fibrotic alterations in severe MR and heart failure. The aim of the present study was to examine the predictive value of Gal-3 and ST2 as specific indicators of therapeutic success in high-risk patients undergoing PMVR...
June 12, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29896859/right-ventricular-base-apex-ratio-in-the-assessment-of-pediatric-pulmonary-arterial-hypertension-results-from-the-european-pediatric-pulmonary-vascular-disease-network
#17
Martin Koestenberger, Alexander Avian, Andreas Gamillscheg, Hannes Sallmon, Gernot Grangl, Ante Burmas, Sabrina Schweintzger, Stefan Kurath-Koller, Gerhard Cvirn, Georg Hansmann
BACKGROUND: Echocardiographic determination of the RV end-systolic base/apex (RVESb/a) ratio was proposed to be of clinical value for the assessment of pulmonary arterial hypertension (PAH) in adults. HYPOTHESIS: We hypothesized that the RVES b/a ratio will be affected in children with PAH and aimed to correlate the RVES b/a ratio with conventionally used echocardiographic and hemodynamic variables, and with NYHA functional class (FC). METHODS: We first determined normal pediatric values for the RVES b/a ratio in 157 healthy children (68 male; age range: 0...
June 12, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29896847/advanced-chronic-kidney-disease-relationship-to-outcomes-post-tavr-a-meta-analysis
#18
REVIEW
Nader Makki, Scott M Lilly
OBJECTIVE: Chronic kidney (CKD) is associated with worse outcomes in high-surgical risk patients undergoing transcatheter aortic valve replacement (TAVR). However, it is unclear whether this relationship is apparent in lower surgical risk patients. Herein we sought to analyze existing literature to assess whether or not advanced CKD is associated with increased mortality, or a greater incidence of adverse events (specifically major stroke, bleeding and vascular complications). METHODS: We searched PubMed and EMBASE (2008-2017) for relevant studies...
June 12, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29896777/comparing-outcomes-after-transcatheter-aortic-valve-replacement-in-patients-with-stenotic-bicuspid-and-tricuspid-aortic-valve-a-systematic-review-and-meta-analysis
#19
Napatt Kanjanahattakij, Benjamin Horn, Wasawat Vutthikraivit, Sylvia Marie Biso, Mary Rodriguez Ziccardi, Marvin Louis Roy Lu, Pattara Rattanawong
BACKGROUND: Transcatheter aortic valve replacement (TAVR) has become an alternative treatment to surgery in patients with severe aortic stenosis (AS). However, patients with Bicuspid aortic stenosis (BiAV) are usually excluded from major TAVR studies. The aim of this study is to reexamine the current evidence of TAVR in patients with severe AS and BiAV comparing to tricuspid aortic valve (TriAV). METHOD: Databases were systematically searched for relevant articles according to the following criteria...
June 12, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29896758/use-of-the-adapted-diabetes-complications-severity-index-to-predict-acute-coronary-syndrome-ischemic-stroke-and-mortality-in-asian-patients-with-type-2-diabetes-mellitus-a-nationwide-cohort-investigation
#20
Wei-Syun Hu, Cheng-Li Lin
OBJECTIVE: We report a retrospective population study aiming at identifying and validating the adapted diabetes complications severity index (DCSI) for acute coronary syndrome (ACS), ischemic stroke and mortality in Asian people with type 2 diabetes mellitus (DM). METHODS: Utilizing the Taiwanese national dataset, we included 84450 type 2 diabetic individuals between 2000 and 2011. The area under the curve in the presentation of receiver operating characteristic (C-statistics of logistic model) and the C-statistics of Cox model were used to evaluate whether the progression of type 2 DM could be a predictor of ACS, ischemic stroke and death...
June 12, 2018: Clinical Cardiology
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