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Digestive Diseases and Sciences

Theresa Nguyen Wenker, Mimi C Tan, Yan Liu, Hashem B El-Serag, Aaron P Thrift
BACKGROUND: Efforts to reduce mortality from esophageal adenocarcinoma (EA) have focused on screening and surveillance of Barrett's esophagus (BE). AIMS: We sought to determine the frequency of prior diagnosis of BE in patients with EA and to evaluate the impact of a prior BE diagnosis on mortality in EA patients. METHODS: This was a retrospective cohort study of patients diagnosed with EA in the VA during 2002-2016. We compared the distributions of EA stage and receipt of treatment between EA patients with and without a prior BE diagnosis and used Cox proportional hazards models to compare mortality risk (all-cause and cancer specific) unadjusted and adjusted for stage and treatment to assess their impact on any survival differences...
August 14, 2018: Digestive Diseases and Sciences
Angela C Tramontano, Ryan Nipp, Nathaniel D Mercaldo, Chung Yin Kong, Deborah Schrag, Chin Hur
BACKGROUND: Survival outcome disparities among esophageal cancer patients exist, but are not fully understood. AIMS: We used the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database to determine whether survival differences among racial/ethnic patient populations persist after adjusting for demographic and clinical characteristics. METHODS: Our study included T1-3N0M0 adenocarcinoma and squamous cell cancer patients diagnosed between 2003 and 2011...
August 14, 2018: Digestive Diseases and Sciences
Amit Kumar Dutta, Grace Rebekah, Sudipta Dhar Chowdhury, Sajith Kattiparambil Gangadharan, Yuvaraj Subramani, Manoj Kumar Sahu, Reuben Thomas Kurien, Deepu David, Ebby George Simon, Anjilivelil Joseph Joseph, Viswanath Reddy Donapati, Ashok Chacko
BACKGROUND: The guidelines for performing endoscopy in dyspeptic patients based on clinical parameters alone have shown variable performance, and there is a need for better prediction tools. AIM: We aimed to prospectively develop and validate a simple clinical-cum-laboratory test-based scoring model to identify dyspeptic patients with high risk of upper gastrointestinal malignancy (UGIM). METHODS: Adult patients with dyspeptic symptoms were prospectively recruited over 5 years...
August 14, 2018: Digestive Diseases and Sciences
Charat Thongprayoon, Wisit Kaewput, Spencer T Hatch, Tarun Bathini, Konika Sharma, Karn Wijarnpreecha, Patompong Ungprasert, Matthew D'Costa, Michael A Mao, Wisit Cheungpasitporn
BACKGROUND/OBJECTIVES: We performed this systematic review and meta-analysis to evaluate effects of probiotics on inflammation, uremic toxins, and gastrointestinal (GI) symptoms in end-stage renal disease (ESRD) patients. METHODS: A literature search was conducted utilizing MEDLINE, EMBASE, and Cochrane Database from inception through October 2017. We included studies that assessed assessing effects of probiotics on inflammatory markers, protein-bound uremic toxins (PBUTs), and GI symptoms in ESRD patients on dialysis...
August 11, 2018: Digestive Diseases and Sciences
Hui-Jing Zhang, Yi-Ning Zhang, Huan Zhou, Lin Guan, Yue Li, Ming-Jun Sun
BACKGROUND: Intestinal fibrosis is a common complication of Crohn's disease (CD). Its exact mechanism is still unclear, and effective treatments to control or reverse the fibrosis process are unavailable. Epithelial-mesenchymal transition (EMT) may promote intestinal fibrosis by increasing deposition of extracellular matrix protein. IL-17A is a pro-inflammatory cytokine, and it has been shown as a profibrotic factor as its association with fibrosis of multiple organs was reported. AIMS: To assess the roles of IL-17A and EMT in the initiation and development of intestinal fibrosis and to verify the potential inductive effect of IL-17A on EMT...
August 10, 2018: Digestive Diseases and Sciences
Adam C Fields, Nelya Melnitchouk
No abstract text is available yet for this article.
August 10, 2018: Digestive Diseases and Sciences
Warapan Nakayuenyongsuk, Danielle Barnes, Brock Martin, Megan Christofferson, John Kerner
No abstract text is available yet for this article.
August 10, 2018: Digestive Diseases and Sciences
Abhijeet Waghray, Nisheet Waghray, Adam T Perzynski, Mark Votruba, M Michael Wolfe
BACKGROUND: Proton pump inhibitors (PPIs) are potent inhibitors of acid secretion and are the mainstay of therapy for gastroesophageal reflux disease (GERD). Initially designed to be taken 30 min before the first daily meal, these agents are commonly used suboptimally, which adversely affects symptom relief. No study to date has assessed whether correcting dosing regimens would improve symptom control. The objective of this study was to determine whether patients with persistent GERD symptoms on suboptimal omeprazole dosing experience symptomatic improvement when randomized to commonly recommended dosing regimen and to evaluate the economic impact of suboptimal PPI dosing in GERD patients...
August 9, 2018: Digestive Diseases and Sciences
Lin Wu, Wujian Xu, Fangyu Wang, Tangfeng Lv, Zhiqiang Yin, Yong Song
BACKGROUND: Specific plasma biomarkers in predicting pancreatic necrosis (PNec) are needed in treating acute pancreatitis (AP). AIMS: To investigate the prognostic value of plasma mitochondrial DNA fragments (mtDNA) in patient with AP for PNec. METHODS: AP patients with symptoms onset within 72 h were prospectively enrolled from June 2015 through June 2017 and were assessed for PNec using contrast-enhanced CT scan. Plasma mtDNA concentration (specific mitochondrial gene ND1) was measured using qRT-PCR...
August 9, 2018: Digestive Diseases and Sciences
Sarah Ballou, Eaman Alhassan, Elise Hon, Cara Lembo, Vikram Rangan, Prashant Singh, William Hirsch, Thomas Sommers, Johanna Iturrino, Judy Nee, Anthony Lembo
BACKGROUND: Poor sleep quality is common among patients with gastrointestinal (GI) disorders. However, few studies have assessed the presence of insomnia or reported circadian preferences and none have directly compared sleep between common GI conditions. AIMS: To compare clinical sleep characteristics in patients presenting to a tertiary care GI clinic for irritable bowel syndrome (IBS), functional dyspepsia (FD), inflammatory bowel disease (IBD), gastroesophageal reflux disease (GERD), and celiac disease (CD)...
August 9, 2018: Digestive Diseases and Sciences
Cameron Sikavi, Lisa Najarian, Sammy Saab
BACKGROUND: Clinical trials evaluating efficacy of direct-acting antiviral (DAA) therapies demonstrate sustained virologic response (SVR) rates greater than 90% in patients infected with hepatitis C (HCV) and human immunodeficiency virus (HIV). However, generalizability of this data to real-world coinfected populations is unknown. AIM: We aim to compare efficacy data from clinical trials to effectiveness data of real-world observational studies that evaluate oral interferon-free HCV treatment regimens in patients infected with HIV and HCV...
August 9, 2018: Digestive Diseases and Sciences
Bechien U Wu, Michael Batech, Elizabeth Y Dong, Lewei Duan, Dhiraj Yadav, Wansu Chen
BACKGROUND AND AIMS: To evaluate impact of ambulatory triglyceride levels on risk of recurrent pancreatitis in patients with hypertriglyceridemic pancreatitis. METHODS: We conducted a longitudinal retrospective cohort study of patients with serum triglyceride level ≥ 500 mg/dL during index hospitalization for acute pancreatitis within a regional integrated healthcare system between 2006 and 2013 (follow-up through 2015). Cases were identified based on combination of diagnosis codes and serum amylase/lipase...
August 9, 2018: Digestive Diseases and Sciences
Yue Li, Hui Xu, Tao Xu, Meng Xiao, Hao Tang, Dong Wu, Bei Tan, Ji Li, Hong Yang, Hong Lv, Yingchun Xu, Jiaming Qian
BACKGROUND AND AIMS: Clostridium difficile infection (CDI) incidence and risk factors in patients with inflammatory bowel disease (IBD) have been extensively studied. However, data describing CDI in Chinese patients with IBD are limited. We investigated the cumulative incidence, risk factors, and outcomes of CDI in Chinese IBD patients. METHODS: We conducted a retrospective, case-control study of patients hospitalized with IBD and CDI at Peking Union Medical College Hospital from January 2010 to December 2015...
August 9, 2018: Digestive Diseases and Sciences
Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND: Obesity and metabolic syndrome are risk factors for colorectal neoplasia (CRN). However, the association between metabolically healthy obese (MHO) or metabolically unhealthy non-obese (MUNO) status and the risk of CRN remains unclear. AIMS: We aimed to elucidate the association between MHO or MUNO status and the risk of CRN. METHODS: A total of 139,023 asymptomatic subjects who underwent a primary screening colonoscopy were categorized into 4 groups according to obesity and metabolic status: metabolically healthy non-obese (MHNO), MHO, MUNO, and metabolically unhealthy obese (MUO)...
August 9, 2018: Digestive Diseases and Sciences
Marisa Claudia Alvarez, Julien Fernandes, Valérie Michel, Eliette Touati, Marcelo Lima Ribeiro
BACKGROUND: GATA factors, which constitute a family of transcription regulatory proteins, participate in gastrointestinal development. Trefoil factor 1 (TFF1) plays a crucial role in mucosal defense and healing, and evidence suggests that GATA-5 mediated its regulation. Gastric cancer is a multiple-step process triggered by Helicobacter pylori and is characterized by accumulation of molecular and epigenetic alteration. The aim of this study was to evaluate the effect of H. pylori infection on the regulation of GATA-5 and TFF1 in vitro and in vivo...
August 6, 2018: Digestive Diseases and Sciences
Monique T Barakat, Subhas Banerjee
No abstract text is available yet for this article.
August 4, 2018: Digestive Diseases and Sciences
Ashley N Tran, Rishabh Sachdev, Zachary P Fricker, Michael Leber, Toni Zahorian, Bhavesh Shah, David P Nunes, Michelle T Long
BACKGROUND: Treatment of hepatitis C virus (HCV) with direct-acting antiviral (DAA) regimens has resulted in high rates of sustained virologic response (SVR). Treatment of vulnerable populations may be improved by incorporating an on-site intensive specialty pharmacy (ON-ISP). AIMS: To describe outcomes of HCV treatment at a safety-net hospital and proportion of subjects achieving SVR for those using the ON-ISP compared to an off-site pharmacy (OFF-SP). METHODS: A retrospective cohort study of 219 subjects treated for HCV with DAA at Boston Medical Center was conducted...
August 4, 2018: Digestive Diseases and Sciences
Yifei Bian, Ping Liu, Jia Zhong, Yusheng Hu, Shen Zhuang, Kai Fan, Zhongjie Liu
BACKGROUND: In inflammatory bowel disease, activation of microvascular endothelial cells and adhesion of immune cells are required for the initiation and maintenance of inflammation. We evaluated the effects and mechanisms of quercetin, a flavone identified in a wide variety of dietary sources, in LPS-induced rat intestinal microvascular endothelial cells (RIMVECs). METHODS: RIMVECs were pretreated with quercetin of various concentrations (20, 40 and 80 μM) followed by LPS (10 μg/ml) stimulation...
August 4, 2018: Digestive Diseases and Sciences
Kirstin Heinrich, James Harnett, Jeffrey Vietri, Richard Chambers, Holly Yu, Marya Zilberberg
BACKGROUND: Evidence of humanistic detriments of Clostridium difficile infection (CDI) remains limited. AIMS: To assess humanistic burden associated with CDI. METHODS: Self-reported National Health and Wellness Survey data between 2013 and 2016 were analyzed for the USA, five European countries, China, and Brazil. Outcome measures included SF-36v2® for health-related quality of life (HRQoL) and Work Productivity and Activity Impairment questionnaire...
August 3, 2018: Digestive Diseases and Sciences
Swathi Paleti, Bharath Yarlagadda, Anas Gremida, Muhammad Aziz, Joshua Hanson, Denis McCarthy
No abstract text is available yet for this article.
August 1, 2018: Digestive Diseases and Sciences
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