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Digestive Diseases and Sciences

Valentine Millien, Daniel Rosen, Jason Hou, Rajesh Shah
BACKGROUND: Microscopic colitis (MC), a subtype of inflammatory bowel disease, is a chronic condition of unknown etiology. Recent evidence has linked MC with intriguing changes in the stool microbiota, which may be linked to disease pathogenesis. The composition of the mucosal microbiome in patients with MC remains unclear. METHODS: We performed a cross-sectional study comparing colonic tissue samples from patients with MC to those of healthy controls at the Michael E...
October 15, 2018: Digestive Diseases and Sciences
Sun Jung Oh, Vartan C Tashjian, James Mirocha, Menachem Nagar, Ruchi Mathur, Eugenia Lin, Kathleen Shari Chua, Ali Rezaie, Mark Pimentel, Nipaporn Pichetshote
BACKGROUND: Irritable bowel syndrome (IBS) is a common chronic disorder of the gastrointestinal tract. Several treatments have been developed, including rifaximin for the treatment of IBS without constipation (non-IBS-C), but no studies have evaluated the effect of these therapies on patient referral rates to tertiary care gastroenterology clinics. AIM: To assess referral patterns for IBS patients at a tertiary motility clinic over a 10-year period. METHODS: Data from consecutive patients referred to the clinic during 2006-2016 were analyzed...
October 15, 2018: Digestive Diseases and Sciences
Sang Hoon Ahn, Patrick Marcellin, Xiaoli Ma, Florin A Caruntu, Won Young Tak, Magdy Elkhashab, Wan-Long Chuang, Fehmi Tabak, Rajiv Mehta, Jörg Petersen, William Guyer, Belinda Jump, Alain Chan, Mani Subramanian, Gerald Crans, Scott Fung, Maria Buti, Giovanni B Gaeta, Aric J Hui, George Papatheodoridis, Robert Flisiak, Henry L Y Chan
The original version of this article unfortunately contained affiliation and textual errors. This has been corrected with this erratum.
October 15, 2018: Digestive Diseases and Sciences
Freddy Caldera, Elizabeth Ann Misch, Sumona Saha, Arnold Wald, Youqi Zhang, Jeffrey Hubers, Bryant Megna, Dana Ley, Mark Reichelderfer, Mary S Hayney
BACKGROUND: The Advisory Committee on Immunization Practices (ACIP) recommends using the immunization record and not serologic testing to determine immunity against measles and rubella in the general population, due to potential false negatives. However, it is unknown whether the immune response is less durable among patients who are immunosuppressed. AIMS: The primary aim of this study was to evaluate sustained vaccine-induced measles, mumps, and rubella (MMR) antibody concentrations in immunosuppressed patients with inflammatory bowel disease (IBD)...
October 13, 2018: Digestive Diseases and Sciences
Omer Faruk Beser, Emine Gulluelli, Fugen Cullu Cokugras, Tulay Erkan, Tufan Kutlu, Rasit Vural Yagci, Firuze Erbek Alp, Gulten Ercal, Nuray Kepil, Mine Kucur
BACKGROUND/AIMS: The aim of this study was to determine the prevalence of celiac disease (CD) in healthy school-aged children in the northern region of Cyprus and to investigate the existence of potential markers that may accompany CD. This is the first study to measure the prevalence of CD in the northern region of Cyprus. METHODS: This study included 3792 school-aged children who were between the ages of 6 and 10 years between January 2015 and October 2016. CD was screened using total serum IgA, IgA anti-tissue transglutaminase (tTG), and IgA antiendomysial (EMA) antibodies...
October 12, 2018: Digestive Diseases and Sciences
Seong Woo Jeon, Hyun Woo Park, Yong Hwan Kwon, Su Youn Nam, Hyun Seok Lee
BACKGROUND: The inappropriate selection of patients with early gastric cancer (EGC) for endoscopic submucosal dissection (ESD) may lead to additional surgery because of a non-curative resection. This study was performed to assess the accuracy of clinical decisions in ESD for EGC. METHODS: A total of 607 cases of EGC treated by ESD were prospectively enrolled from January 2011 to June 2014 at a single academic hospital. The 607 EGCs were divided into three groups (overestimated, same-estimated, and underestimated) based on pre-procedure endoscopic findings (indication) and pathological diagnosis after ESD (criteria)...
October 11, 2018: Digestive Diseases and Sciences
Seema A Patil, Mark H Flasar, Jay Lin, Melissa Lingohr-Smith, Martha Skup, Song Wang, Jingdong Chao, Raymond K Cross
BACKGROUND: Radiation exposure from diagnostic imaging may increase cancer risk of Crohn's disease (CD) patients, who are already at increased risk of certain cancers. AIM: To compare imaging radiation exposure and associated costs in CD patients during the year pre- and post-initiation of anti-tumor necrosis factor (anti-TNF) agents or corticosteroids. METHODS: Adults were identified from a large US claims database between 1/1/2005 and 12/31/2009 with ≥ 1 abdominal imaging scan and 12 months of enrollment before and after initiating therapy with anti-TNF or corticosteroids...
October 11, 2018: Digestive Diseases and Sciences
Mandana Khalili, Robert J Wong
No abstract text is available yet for this article.
October 11, 2018: Digestive Diseases and Sciences
L Allyson Checkley, Loretta Kristofek, Samantha Kile, William Bolgar
BACKGROUND: Infliximab is a chimeric anti-tumor necrosis factor alpha (TNF-α) monoclonal antibody that ameliorates inflammation when it binds to and neutralizes TNF-α. It is often used in patients with Crohn's disease and ulcerative colitis to reduce the severity of disease symptoms and induce disease remission. Infusions are generally administered in the hospital setting due to concerns over patient safety, and limited data exist regarding the incidence and management of infusion reactions (IRs) in an alternate care setting without direct physician oversight...
October 11, 2018: Digestive Diseases and Sciences
Yanping Hu, Xiaojing Teng, Linlin Wu, Wei Liu, Jianduo An
BACKGROUND: Esophageal squamous cell precursor lesions remain one of the most controversial topics in pathology and clinical management. AIMS: To analyze the dysregulation of human telomerase RNA component (hTERC) in esophageal squamous cell precursor lesions and the clinicopathological correlations with the characteristics of esophageal squamous cell precursor lesions. METHODS: Florescence in situ hybridization was performed to detect hTERC amplification in different gradings of esophageal squamous cell precursor lesions...
October 11, 2018: Digestive Diseases and Sciences
Reut Doyev, Shlomi Cohen, Amir Ben-Tov, Yael Weintraub, Achiya Amir, Tut Galai, Hadar Moran-Lev, Anat Yerushalmy-Feler
BACKGROUND AND AIMS: Approximately 10% of children with celiac disease (CD) have ultra-short celiac disease (USCD), where histological abnormalities are limited to the duodenal bulb. The aim of our retrospective study was to identify clinical and serological characteristics at baseline and at follow-up of children with USCD. METHODS: All children that were diagnosed with CD in our unit during 7/2010-12/2017, in whom biopsies were taken from duodenal bulb and second part, were included...
October 11, 2018: Digestive Diseases and Sciences
Mahendran Jayaraj, Babu P Mohan, Banreet S Dhindsa, Harmeet S Mashiana, Gowri Radhakrishnan, Vinay Dhir, Arvind J Trindade, Douglas G Adler
INTRODUCTION: Periampullary diverticulum (PAD) is most often asymptomatically found in elderly population. ERCP in the presence of PAD is technically challenging since the location and orientation of the ampulla could be altered. Various studies have reported differing results on the technical success and safety outcomes of ERCP in the presence of PAD. We aimed at a meta-analysis of such studies to assess the technical success and the occurrence of complications during ERCP in patients with PAD...
October 6, 2018: Digestive Diseases and Sciences
Kuei-Chuan Lee, Wei-Fan Hsu, Yun-Cheng Hsieh, Che-Chang Chan, Ying-Ying Yang, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin
BACKGROUND: Liver fibrosis can progress to cirrhosis, hepatocellular carcinoma, or liver failure. Unfortunately, the antifibrotic agents are limited. Thrombin activates hepatic stellate cells (HSCs). Therefore, we investigated the effects of a direct thrombin inhibitor, dabigatran, on liver fibrosis. METHODS: Adult male Sprague-Dawley rats were injected intraperitoneally with thioacetamide (TAA, 200 mg/kg twice per week) for 8 or 12 weeks to induce liver fibrosis...
October 4, 2018: Digestive Diseases and Sciences
Sang Yeon Cho, Sungha Kim, Mi-Ju Son, Woo Sun Rou, Seok Hyun Kim, Hyuk Soo Eun, Byung Seok Lee
BACKGROUND: Oxidative stress occurs due to the excessive generation of cellular reactive oxygen species and antioxidant system dysfunction. The thioredoxin (TXN) system and TXN-domain-containing protein (TXNDC) family form networks maintaining the cellular reducing environment. Recently, the importance of these genes in the tumor environment has been emphasized. AIM: To investigate the clinical significance of TXNs and TXNDC family members in HCC. METHODS: Genomic data from 367 hepatocellular carcinoma (HCC) patients who underwent hepatic resections were analyzed to determine genetic alterations in mRNA and protein levels between patients and healthy controls...
October 4, 2018: Digestive Diseases and Sciences
Yan Jiao, Yanqing Li, Zhengyang Lu, Yahui Liu
BACKGROUND: Trophinin-associated protein (TROAP) is a cytoplasmic protein that functions as an adhesion molecule in processes such as embryo implantation, spindle formation, and cancer. OBJECTIVE: To evaluate the relationship of TROAP expression in hepatocellular carcinoma (HCC) tissue with clinicopathologic parameters and survival time in liver cancer patients based on an analysis of The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) data. METHODS: RNA-sequencing (RNA-Seq) expression data and clinical information were downloaded for the TCGA-LIHC cohort...
October 4, 2018: Digestive Diseases and Sciences
Hidenori Tanaka, Shiro Oka, Shinji Tanaka, Kenta Matsumoto, Kazuki Boda, Ken Yamashita, Daiki Hirano, Kyoku Sumimoto, Yuzuru Tamaru, Yuki Ninomiya, Nana Hayashi, Kazuaki Chayama
BACKGROUND: The endoscopic lens becomes clouded and its visibility reduces during colorectal endoscopic submucosal dissection (ESD), especially in cases with submucosal fatty tissue. Dual red imaging (DRI) is a novel image-enhanced endoscopic technique that improves endoscopic visibility. AIMS: This study aimed to evaluate the predictive factors of submucosal fatty tissue and the clinical usefulness of DRI in maintaining clear visibility during colorectal ESD. METHODS: The study participants included 586 consecutive patients with 645 colorectal tumors who underwent ESD between January 2014 and July 2017...
October 4, 2018: Digestive Diseases and Sciences
Siqing Feng, Qiongqiong Wei, Qing Hu, Xiaomei Huang, Xi Zhou, Gang Luo, Mingming Deng, Muhan Lü
Acute pancreatitis is a human disease with multiple causes that leads to autodigestion of the pancreas. There is sufficient evidence to support the key role of sustained increase in cytosolic calcium concentrations in the early pathogenesis of the disease. To clarify the mechanism of maintaining calcium homeostasis in the cell and pathological processes caused by calcium overload would help to research directly targeted therapeutic agents. We will specifically review the following: intracellular calcium homeostasis and regulation, the occurrence of calcium overload in acinar cells, the role of calcium overload in the pathogenesis of AP, the treatment strategy proposed for calcium overload...
October 3, 2018: Digestive Diseases and Sciences
Xiaoling Jin, Teresa A Zimmers, Zongxiu Zhang, Leonidas G Koniaris
INTRODUCTION: Loss of hepatic epidermal growth factor receptor (EGFR) expression is a cause for the increased perioperative risk for complications and death in patients with obesity and fatty liver undergoing liver resection. Herein, we set out to identify agents that might increase EGFR expression and improve recovery for patients with fatty liver undergoing resection. Using the diet-induced obese (DIO) mouse model of fatty liver, we examined resveratrol as a therapy to induce EGFR expression and improve outcomes following 80% partial hepatectomy (PH) in a murine model...
October 3, 2018: Digestive Diseases and Sciences
Salman Nusrat, Taseen Syed, Rabia Saleem, Shari Clifton, Klaus Bielefeldt
BACKGROUND: Widespread opioid use has led to increase in opioid-related adverse effects like constipation. We examined the impact of study endpoints on reported treatment benefits. METHODS: Using MEDLINE, EMBASE, and, we searched for randomized control trials targeting chronic opioid-induced constipation (OIC) and subjected them to meta-analysis. Data are given with 95% confidence intervals. RESULTS: Thirty trials met our inclusion criteria...
October 3, 2018: Digestive Diseases and Sciences
Hideyuki Chiba, Ken Ohata, Jun Tachikawa, Jun Arimoto, Keiichi Ashikari, Hiroki Kuwabara, Michiko Nakaoka, Toru Goto, Atsushi Nakajima
BACKGROUND: Endoscopic submucosal dissection (ESD) is an effective treatment for early-colorectal cancer. Although delayed bleeding is a serious potential complication, there is no consensus on the optimal protocol to determine which cases require emergency colonoscopy. AIMS: This study aimed to assess the risk factors for delayed bleeding after ESD and evaluate the "watch and wait" strategy for delayed bleeding. The "watch and wait" strategy was used for delayed bleeding, unless the shock index was ≥ 1 and/or a moderate amount of hematochezia occurred more than five occurrences...
October 3, 2018: Digestive Diseases and Sciences
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