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Digestive Diseases and Sciences

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https://www.readbyqxmd.com/read/29052819/getting-a-low-grade-for-missing-high-grade-dysplasia-and-colorectal-cancer-in-ibd
#1
EDITORIAL
James R Conner, Robert H Riddell
No abstract text is available yet for this article.
October 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29052818/out-of-pocket-cost-is-a-barrier-to-therapeutic-drug-monitoring-in-inflammatory-bowel-disease
#2
James P Campbell, Erin Burton, Shelly Wymer, Michael Shaw, Byron P Vaughn
BACKGROUND: Therapeutic drug monitoring (TDM) is increasingly performed to optimize biologic therapy in inflammatory bowel disease (IBD). However, patients and physicians may be reluctant to perform TDM due to concerns related to potential out-of-pocket costs. AIMS: The aim of this study was to evaluate patient understanding and attitudes toward TDM in different clinical scenarios with and without potential out-of-pocket costs. METHODS: Adult IBD patients at a tertiary gastroenterology clinic were anonymously surveyed from March to September 2016 to assess their understanding of and willingness to undergo TDM in a variety of clinical scenarios, both with and without a potential out-of-pocket cost...
October 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29052817/androgen-signaling-in-esophageal-adenocarcinoma-cell-lines-in-vitro
#3
Helen M Palethorpe, Paul A Drew, Eric Smith
BACKGROUND: We showed previously that nuclear localization of the androgen receptor (AR) and expression of the androgen-responsive gene FK506-binding protein 5 (FKBP5) in esophageal adenocarcinoma (EAC) tissues were associated with decreased patient survival, suggesting a role for androgens in this cancer. AIM: To investigate the effect of the AR ligand 5α-dihydrotestosterone (DHT) on AR-expressing EAC cell lines in vitro. METHODS AND RESULTS: In tissue resection specimens from EAC patients, FKBP5 expression was positively associated with proliferation as measured by Ki-67 expression...
October 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29052816/depressive-symptoms-predict-anti-tumor-necrosis-factor-therapy-noncompliance-in-patients-with-inflammatory-bowel-disease
#4
Alexis Calloway, Robin Dalal, Dawn B Beaulieu, Caroline Duley, Kimberly Annis, Lawrence Gaines, Chris Slaughter, David A Schwartz, Sara Horst
BACKGROUND: Noncompliance in use of anti-tumor necrosis factor (anti-TNF) therapy in patients with moderate-to-severe inflammatory bowel disease (IBD) can be a factor in medication failure. Few studies have evaluated the contribution of depressive symptoms to medication noncompliance in anti-TNF therapies. METHODS: A retrospective chart review was performed in a single-center tertiary care IBD center for patients with Crohn's disease and ulcerative colitis starting anti-TNF therapy over a 2-year period...
October 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29043596/short-term-prospective-questionnaire-study-of-early-postoperative-quality-of-life-after-colorectal-endoscopic-submucosal-dissection
#5
Fumihiko Nakamura, Yutaka Saito, Shin Haruyama, Masau Sekiguchi, Masayoshi Yamada, Taku Sakamoto, Takeshi Nakajima, Seiichiro Yamamoto, Yoshitaka Murakami, Hideki Ishikawa, Takahisa Matsuda
BACKGROUND: Endoscopic submucosal dissection (ESD) has become popular as an alternative to laparoscopy-assisted colectomy (LAC) for early colorectal cancer. AIM: To validate postoperative quality of life (QOL) based on subjective symptoms of patients from questionnaire survey. METHODS: We prospectively enrolled patients planned to undergo ESD for adenoma or Tis/T1a cancer at our institution between December 2011 and January 2013. Controls were prospectively enrolled LAC patients diagnosed with T1b cancer...
October 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29043595/stress-hormone-cortisol-enhances-bcl2-like-12-expression-to-inhibit-p53-in-hepatocellular-carcinoma-cells
#6
Weizhong Wu, Sanguang Liu, Yunfei Liang, Zegao Zhou, Wei Bian, Xueqing Liu
BACKGROUND AND AIMS: The pathogenesis of hepatocellular carcinoma (HC) is unclear. It is suggested that psychological stress associates with the pathogenesis of liver cancer. Bcl2-like protein 12 (Bcl2L12) suppresses p53 protein. This study tests a hypothesis that the major stress hormone, cortisol, inhibits the expression of p53 in HC cells (HCC) via up regulating the expression of Bcl2L12. METHODS: Peripheral blood samples were collected from patients with HC to be analyzed for the levels of cortisol...
October 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29043594/specialty-care-access-network-extension-of-community-healthcare-outcomes-model-program-for-liver-disease-improves-specialty-care-access
#7
Lisa M Glass, Akbar K Waljee, Heather McCurdy, Grace L Su, Anne Sales
BACKGROUND AND AIMS: To improve subspecialty access, VA Ann Arbor Healthcare System (VAAAHS) implemented the first Specialty Care Access Network (SCAN)-Extension of Community Healthcare Outcomes (ECHO) in chronic liver disease. SCAN-ECHO Liver links primary care providers (PCPs) to hepatologists via secure video-teleconferencing. We aim to describe characteristics of participants (PCPs) and patients (clinical question and diagnosis) in SCAN-ECHO Liver. METHODS: This is a prospective study of the VAAAHS SCAN-ECHO Liver (June 10, 2011-March 31, 2015)...
October 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29043593/fecal-calprotectin-in-monitoring-the-disease-activity-in-colonic-inflammatory-bowel-disease
#8
LETTER
Cong Dai, Min Jiang, Ming-Jun Sun
No abstract text is available yet for this article.
October 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29043592/factors-associated-with-surveillance-adenoma-and-sessile-serrated-polyp-detection-rates
#9
Jennifer K Maratt, Joseph Dickens, Philip S Schoenfeld, Grace H Elta, Kenya Jackson, Daniel Rizk, Christine Erickson, Stacy B Menees
BACKGROUND: Adenoma detection rate (ADR) and sessile serrated polyp detection rate (SSPDR) data in surveillance colonoscopy are limited. AIMS: Our aim was to determine surveillance ADR and SSPDR and identify associated predictors. METHODS: A retrospective review of subjects who underwent surveillance colonoscopy for adenoma and/or SSP at an academic center was performed. The following exclusion criteria were applied: prior colonoscopy ≤ 3 years, incomplete examination, or another indication for colonoscopy...
October 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29030745/modulation-of-gut-microbiota-by-maillard-reaction-products-in-intestinal-inflammation-are-we-what-we-eat
#10
EDITORIAL
Adam Fabisiak
No abstract text is available yet for this article.
October 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29030744/peptide-tyrosine-tyrosine-3-36-reduces-meal-size-and-activates-the-enteric-neurons-in-male-sprague-dawley-rats
#11
Kayla D Newman, Thaer R Mhalhal, Martha C Washington, John C Heath, Ayman I Sayegh
BACKGROUND: Peptide tyrosine tyrosine 3-36 (peptide YY 3-36 or PYY 3-36) reduces food intake by unknown site(s). AIM: To test the hypothesis that the gastrointestinal tract contains sites of action regulating meal size (MS) and intermeal interval (IMI) length by PYY 3-36. METHODS: Peptide YY 3-36 (0, 1, 5, 10 and 20 nmol/kg) was injected in the aorta, the artery that supplies the gastrointestinal tract, prior to the onset of the dark cycle in free feeding male Sprague-Dawley rats and food intake was measured...
October 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29030743/mir-182-and-mir-135b-mediate-the-tumorigenesis-and-invasiveness-of-colorectal-cancer-cells-via-targeting-st6galnac2-and-pi3k-akt-pathway
#12
Li Jia, Shihua Luo, Xiang Ren, Yang Li, Jialei Hu, Bing Liu, Lifen Zhao, Yujia Shan, Huimin Zhou
BACKGROUND: Metastasis is a leading cause of cancer-related death including colorectal cancer (CRC). MicroRNAs are known to regulate cancer pathways and to be expressed aberrantly in cancer. Aberrant sialylation is closely associated with malignant phenotype of tumor cells, including invasiveness and metastasis. AIM: This study aimed to investigate the association of miR-182 and miR-135b with proliferation and invasion by targeting sialyltransferase ST6GALNAC2 in CRC cells and explore the potential molecular mechanism...
October 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29030742/pten-gene-induces-cell-invasion-and-migration-via-regulating-akt-gsk-3%C3%AE-%C3%AE-catenin-signaling-pathway-in-human-gastric-cancer
#13
Jingjing Ma, Xufeng Guo, Jixiang Zhang, Dandan Wu, Xue Hu, Jiao Li, Qingzhi Lan, Ya Liu, Weiguo Dong
BACKGROUND: Abnormality of PTEN gene and Wnt/β-catenin signaling have been strongly implicated in various malignant cancers. Recently, it has been noted that a functional interaction/cross-talk was found between the PTEN/PI3K/AKT and Wnt/β-catenin, which plays a key role in the development of cancers. However, few related studies on gastric cancer are available. AIM: We examined the expression of PTEN and β-catenin in gastric cancer tissues and detected whether down-regulation of PTEN promotes the migration and invasion in gastric cancer cells along with its underlying mechanism...
October 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29027652/correction-to-tumor-volume-doubling-time-as-a-dynamic-prognostic-marker-for-patients-with-hepatocellular-carcinoma
#14
Jong Kwan Kim, Hyung-Don Kim, Mi-Jung Jun, Sung-Cheol Yun, Ju Hyun Shim, Han Chu Lee, Danbi Lee, Jihyun An, Young-Suk Lim, Young-Hwa Chung, Yung Sang Lee, Kang Mo Kim
The original version of this article unfortunately contained an error in corresponding author e-mail. It was submitted and published as kimkim70@amc.seoul.kr instead of kimkm70@amc.seoul.kr.
October 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29027599/dyspepsia-diarrhea-and-deafness-some-calling-cards-of-the-great-mimic
#15
Anas Gremida, Muqeet Adnan, Vidit Kappor, Farzana Harji, Joseph Glass, Denis McCarthy
No abstract text is available yet for this article.
October 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29022147/interventional-activism-in-gastroenterology
#16
LETTER
Amnon Sonnenberg, Brintha K Enestvedt, Gennadiy Bakis
No abstract text is available yet for this article.
October 11, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28993968/enteral-autonomy-with-teduglutide-treatment-of-intestinal-failure-short-bowel-syndrome-with-depleted-central-venous-access
#17
Mohammad M Jami, Russell J Merritt
No abstract text is available yet for this article.
October 9, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28993941/il-8-is-involved-in-estrogen-related-receptor-%C3%AE-regulated-proliferation-and-migration-of-colorectal-cancer-cells
#18
Sijuan Ding, Zhaohui Tang, Yongjun Jiang, Honglin Huang, Pengfei Luo, Bohua Qing, Siyuan Zhang, Ruoting Tang
BACKGROUND AND AIMS: Studies revealed that estrogenic signals were involved in the development of colorectal cancer (CRC), while the roles of estrogen related receptor (ERR) on the progression of CRC have not been well illustrated. Its roles on the development of CRC were investigated. METHODS: The expression of ERRα/β/γ in CRC cells were measured. The effects of ERRα on cell proliferation, migration and expression of cytokines were investigated accordingly...
October 9, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28986716/cirrhosis-is-associated-with-increased-mortality-in-patients-with-diverticulitis-a-nationwide-cross-sectional-study
#19
Andrew J Kruger, Khalid Mumtaz, Ahmad Anaizi, Rohan M Modi, Hisham Hussan, Cheng Zhang, Alice Hinton, Darwin L Conwell, Somashekar G Krishna, Peter P Stanich
BACKGROUND: Diverticulitis in patients with cirrhosis has been associated with higher surgical mortality, but no prior studies evaluate non-surgical treatment results. AIMS: Our aim was to compare the outcomes of hospitalization for diverticulitis in patients with and without cirrhosis. METHODS: We utilized the Nationwide Inpatient Sample (2007-2013) for patients with and without cirrhosis hospitalized for diverticulitis. Patients were further stratified by the presence of compensated versus decompensated cirrhosis...
October 6, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28986667/prolonged-release-oxycodone-naloxone-improves-anal-sphincter-relaxation-compared-to-oxycodone-plus-macrogol-3350
#20
Jakob Lykke Poulsen, Christina Brock, Debbie Grønlund, Donghua Liao, Hans Gregersen, Klaus Krogh, Asbjørn Mohr Drewes
BACKGROUND: Opioid analgesics inhibit anal sphincter function and contribute to opioid-induced bowel dysfunction (OIBD). However, it is unknown whether the inhibition can be reduced by opioid antagonism with prolonged-release (PR) naloxone and how this compares to laxative treatment. AIMS: To compare the effects of combined PR oxycodone/naloxone or PR oxycodone plus macrogol 3350 on anal sphincter function and gastrointestinal symptoms. METHODS: A randomized, double-blind, crossover trial was conducted in 20 healthy men...
October 6, 2017: Digestive Diseases and Sciences
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