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Digestive Diseases and Sciences

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https://www.readbyqxmd.com/read/28229252/pain-in-patients-with-pancreatic-cancer-prevalence-mechanisms-management-and-future-developments
#1
REVIEW
Andreas I Koulouris, Paul Banim, Andrew R Hart
Pain affects approximately 80% of patients with pancreatic cancer, with half requiring strong opioid analgesia, namely: morphine-based drugs on step three of the WHO analgesic ladder (as opposed to the weak opioids: codeine and tramadol). The presence of pain is associated with reduced survival. This article reviews the literature regarding pain: prevalence, mechanisms, pharmacological, and endoscopic treatments and identifies areas for research to develop individualized patient pain management pathways. The online literature review was conducted through: PubMed, Clinical Key, Uptodate, and NICE Evidence...
February 22, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28224253/lrrk2-expression-in-the-enteric-nervous-system-ensuring-its-significance
#2
EDITORIAL
Pascal Derkinderen
No abstract text is available yet for this article.
February 21, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28220262/imaging-pancreatic-cysts-with-ct-and-mri
#3
REVIEW
R Brooke Jeffrey
CT and MRI are the imaging modalities of choice to guide the clinical management of incidentally discovered pancreatic cysts. Most of these lesions are mucinous cysts with varying degrees of malignant potential. This article reviews the CT and MRI findings that help differentiate a potentially aggressive lesion that requires EUS or surgery from a lesion of low malignant potential that is appropriate for imaging surveillance. The imaging-based societal guidelines for these cysts are reviewed.
February 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28210907/erratum-to-multicenter-prospective-study-on-the-safety-of-upper-gastrointestinal-endoscopic-procedures-in-antithrombotic-drug-users
#4
Yoshiyasu Kono, Minoru Matsubara, Tatsuya Toyokawa, Ryuta Takenaka, Seiyu Suzuki, Junichirou Nasu, Masao Yoshioka, Masahiro Nakagawa, Motowo Mizuno, Hiroyuki Sakae, Makoto Abe, Tatsuhiro Gotoda, Ko Miura, Hiromitsu Kanzaki, Masaya Iwamuro, Keisuke Hori, Takao Tsuzuki, Masahide Kita, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada
No abstract text is available yet for this article.
February 16, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28210906/suspected-liver-injury-and-the-dilemma-of-causality
#5
LETTER
Rolf Teschke, Axel Eickhoff
For causality assessment in cases of suspected liver injury, RUCAM provides objective and transparent results and should be the preferred tool rather than the DILIN method, which is based on subjective opinion.
February 16, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28205111/risk-factors-for-bile-duct-injury-after-percutaneous-thermal-ablation-of-malignant-liver-tumors-a-retrospective-case-control-study
#6
Man-Xia Lin, Jie-Yi Ye, Wen-Shuo Tian, Ming Xu, Bo-Wen Zhuang, Ming-De Lu, Xiao-Yan Xie, Ming Kuang
BACKGROUND: Bile duct injury after ablation of malignant liver tumors (MLTs) was not unusual and should be avoided. However, few studies have focused on evaluating the risk factors for intrahepatic bile duct injury. AIM: To evaluate the risk factors for intrahepatic bile duct injury after ablation of MLTs and to evaluate the minimum safe distance for ablating tumors abutting bile ducts. METHODS: Sixty-five patients with intrahepatic bile duct injury after ablation of MLTs, and 65 controls were recruited...
February 15, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28205110/psychological-comorbidity-and-chronic-heartburn-which-is-the-chicken-and-which-is-the-egg
#7
EDITORIAL
Ronnie Fass, Shira S Fass
No abstract text is available yet for this article.
February 15, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28205109/acknowledgment-of-2016-reviewers
#8
(no author information available yet)
No abstract text is available yet for this article.
February 15, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28197743/the-impact-of-therapeutic-antibodies-on-the-management-of-digestive-diseases-history-current-practice-and-future-directions
#9
EDITORIAL
M Anthony Sofia, David T Rubin
The development of therapeutic antibodies represents a revolutionary change in medical therapy for digestive diseases. Beginning with the initial studies that confirmed the pathogenicity of cytokines in inflammatory bowel disease, the development and application of therapeutic antibodies brought challenges and insights into their potential and optimal use. Infliximab was the first biological drug approved for use in Crohn's disease and ulcerative colitis. The lessons learned from infliximab include the importance of immunogenicity and the influence of pharmacokinetics on disease response and outcomes...
February 14, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28197742/novel-biomarkers-for-pancreatic-cysts
#10
REVIEW
Harkirat Singh, Kevin McGrath, Aatur D Singhi
With increased utilization and ongoing advancements in cross-sectional abdominal imaging, the identification of a pancreatic cyst has become a frequent finding. While many pancreatic cysts are associated with a benign clinical course, others may transform into pancreatic ductal adenocarcinoma. However, distinguishing a benign from a malignant pancreatic cyst or pancreatic cyst with malignant potential on the basis of standard clinical findings, imaging parameters and ancillary studies can be challenging. Hence, a significant interest within the past decade has been the identification of novel biomarkers to accurately classify and prognosticate a pancreatic cyst...
February 14, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28194671/activation-of-insulin-pi3k-akt-p70s6k-pathway-in-hepatic-stellate-cells-contributes-to-fibrosis-in-nonalcoholic-steatohepatitis
#11
Cindy X Cai, Hema Buddha, Shobha Castelino-Prabhu, Zhiwei Zhang, Robert S Britton, Bruce R Bacon, Brent A Neuschwander-Tetri
BACKGROUND AND AIMS: Hyperinsulinemia and insulin resistance are hallmark features of nonalcoholic fatty liver disease and steatohepatitis (NASH). It remains unclear whether and how insulin contributes to the development of fibrosis in NASH. In this study, we explored insulin signaling in the regulation of hepatic stellate cell (HSC) activation and the progression of NASH-fibrosis. METHODS: Phosphorylation of Akt and p70S6K were examined in primary HSC and in a rat model of NASH-fibrosis induced by high-fat and high-cholesterol diet for 24 weeks...
February 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28194670/state-of-the-art-in-airway-management-during-gi-endoscopy-the-missing-pieces
#12
LETTER
M Sorbello, G S Pulvirenti, D Pluchino, M Skinner
No abstract text is available yet for this article.
February 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28194669/mir-143-targeting-tak1-attenuates-pancreatic-ductal-adenocarcinoma-progression-via-mapk-and-nf-%C3%AE%C2%BAb-pathway-in-vitro
#13
Feng-Ting Huang, Juan-Fei Peng, Wen-Jie Cheng, Yan-Yan Zhuang, Ling-Yun Wang, Chu-Qiang Li, Jian Tang, Wen-Ying Chen, Yuan-Hua Li, Shi-Neng Zhang
BACKGROUND: Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) is one of the major regulators of inflammation-induced cancer cell growth and progression. MiR-143 dysregulation is a common event in a variety of human diseases including pancreatic ductal adenocarcinoma (PDA). AIMS: To identify the interaction between TAK1 and miR-143 in PDA. METHODS: Data mining of TAK1 expression in PDA patient gene profiling was conducted. QRT-PCR and western blot were performed to detect the expression of TAK1 in PDA tissues and cell lines...
February 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28194668/value-of-raw-rhubarb-solution-in-the-precaution-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-in-patients-with-high-risk-factors-a-predictive-random-compared-research-in-one-center
#14
Chong Wang, Qirui Li, Peng Ye, Sheng Zeng, Guo-Hua Li, You-Xiang Chen, Xiao-Jiang Zhou, Nong-Hua Lv
BACKGROUND AND AIMS: Post-ERCP pancreatitis and hyperamylasemia are common complications of endoscopic retrograde cholangiopancreatography (ERCP), especially in high-risk patients. The aim of this study is to evaluate whether a raw rhubarb solution can reduce the incidence of PEP and post-ERCP hyperamylasemia. METHODS: From October 2012 to October 2013, 2100 patients received ERCP in our Endoscopic Center. Five hundred patients with high-risk factors were enrolled randomly into the raw rhubarb group (RG, 250 cases drank a raw rhubarb soak solution per 3 h until defecation after ERCP) and the control group (CG, 250 cases drank water after ERCP) in the study...
February 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28194667/three-dimensional-anorectal-manometry-enhances-diagnostic-gain-by-detecting-sphincter-defects-and-puborectalis-pressure
#15
Shreya Raja, Francis C Okeke, Ellen M Stein, Sameer Dhalla, Monica Nandwani, Kristle L Lynch, C Prakash Gyawali, John O Clarke
BACKGROUND: Constipation and fecal incontinence (FI) are common and are often evaluated with anorectal manometry. Three-dimensional high-resolution anorectal manometry (HRAM) is a promising technology; however, implementation has been limited by lack of metrics and unclear clinical utility. AIM: To investigate the diagnostic utility of 3D HRAM compared to 2D HRAM. METHODS: Three-dimensional HRAM studies performed from April 2012 to October 2013 were identified and re-interpreted by two blinded investigators examining 3D function...
February 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28194666/increasing-burden-of-chronic-liver-disease-among-adolescents-and-young-adults-in-the-usa-a-silent-epidemic
#16
Iliana Doycheva, Kymberly D Watt, Ghassoub Rifai, Rachel Abou Mrad, Rocio Lopez, Nizar N Zein, William D Carey, Naim Alkhouri
BACKGROUND AND AIMS: Chronic liver disease (CLD) starts or becomes established in the adolescent and young adult (AYA) age group. This study aimed to estimate trends in CLD prevalence among US AYAs and to assess factors associated with CLD. METHODS: Cross-sectional data from 14,547 AYAs (population-weighted N = 68,274,386) aged 15-39 years enrolled in the National Health and Nutrition Examination Survey from 1988 to 2012 were used. Nonalcoholic fatty liver disease (NAFLD) was defined as elevated alanine aminotransferase (>19 U/L for females and >30 U/L for males) in subjects with BMI ≥ 25 kg/m(2); alcoholic liver disease (ALD) as excessive alcohol use (≥3 drinks/day for men and ≥2 drinks/day for women) and elevated aminotransferases after excluding alternative etiologies...
February 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28194665/performance-improvement-quality-is-in-the-cards
#17
EDITORIAL
Emily J Campbell, James M Richter
No abstract text is available yet for this article.
February 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28194597/celiac-disease-treatment-is-it-the-chicken-or-the-egg-yolk
#18
EDITORIAL
Valentina Discepolo, Stefano Guandalini
No abstract text is available yet for this article.
February 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28194596/a-recurrent-theme-a-nationwide-analysis-of-hospitalization-for-cyclic-vomiting-syndrome
#19
EDITORIAL
Robert Issenman
No abstract text is available yet for this article.
February 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28194595/double-balloon-colonoscopy-has-a-higher-cecal-intubation-rate-than-conventional-colonoscopy-using-a-colon-simulator
#20
Keijiro Sunada, Satoshi Shinozaki, Tomonori Yano, Yoshikazu Hayashi, Hirotsugu Sakamoto, Alan Kawarai Lefor, Hironori Yamamoto
BACKGROUND/AIM: Cecal intubation using conventional colonoscopy (CC) requires substantial training. We hypothesized that double-balloon colonoscopy (DBC) facilitates cecal intubation by endoscopy naïve operators. The aim of this study is to evaluate the cecal intubation rate and learning curve of DBC compared with CC. METHODS: Eighteen endoscopy naïve medical students were allocated to two groups and attempted cecal intubation within 20 min using a colon simulator...
February 13, 2017: Digestive Diseases and Sciences
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