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Digestive Diseases and Sciences

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https://www.readbyqxmd.com/read/28823082/mir-3910-promotes-the-growth-and-migration-of-cancer-cells-in-the-progression-of-hepatocellular-carcinoma
#1
Lina Cheng, Hongwei Wang, Shuangyin Han
INTRODUCTION: Previous studies have reported that specific depletion of mammalian sterile-like kinase (MST1) in the mouse liver driven Hepatocellular carcinoma (HCC). However, how the expression of MST1 was regulated in the progression of HCC remains largely unknown. MATERIALS AND METHODS: The expression of miR-3910 in the HCC tissues and cell lines were examined using q-PCR. The functions of miR-3910 in HCC were examined using MTT assay, Boyden chamber assay and soft agar assay...
August 19, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28823012/ratio-of-circulating-estrogen-receptors-beta-and-alpha-er%C3%AE-er%C3%AE-indicates-endoscopic-activity-in-patients-with-crohn-s-disease
#2
Pablo M Linares, Alicia Algaba, Ana Urzainqui, Mercedes Guijarro-Rojas, Rafael González-Tajuelo, Jesús Garrido, María Chaparro, Javier P Gisbert, Fernando Bermejo, Iván Guerra, Víctor Castellano, María-Encarnación Fernández-Contreras
BACKGROUND: Data supporting a role of female hormones and/or their receptors in inflammatory bowel disease (IBD) are increasing, but most of them are derived from animal models. Estrogen receptors alpha (ERα) and beta (ERβ) participate in immune and inflammatory response, among a variety of biological processes. Their effects are antagonistic, and the net action of estrogens may depend on their relative proportions. AIM: To determine the possible association between the balance of circulating ERβ and ERα (ERβ/ERα) and IBD risk and activity...
August 19, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28822006/long-term-outcomes-of-adalimumab-treatment-in-254-patients-with-crohn-s-disease-a-hospital-based-cohort-study-from-korea
#3
Hyungil Seo, Byong Duk Ye, Eun Mi Song, Sun-Ho Lee, Kiju Chang, Ho-Su Lee, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
BACKGROUND AND AIMS: Large-scale studies regarding the long-term outcomes of adalimumab (ADA) treatment in Asian patients with Crohn's disease (CD) are still scarce. METHODS: We retrospectively analyzed the long-term outcomes of ADA treatment in Korean CD patients who commenced on scheduled ADA treatment at Asan Medical Center between November 2008 and July 2016. Clinical response was defined as maintaining ADA treatment without dose intensification (DI) and/or major abdominal surgery (MAS)...
August 18, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28815403/overexpression-of-topoisomerase-2-alpha-confers-a-poor-prognosis-in-pancreatic-adenocarcinoma-identified-by-co-expression-analysis
#4
Zhou Zhou, Shi Liu, Meng Zhang, Rui Zhou, Jing Liu, Ying Chang, Qiu Zhao
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of human cancer-related death in the developed countries. Its progression and prognosis are influenced by a complex network of gene interactions. AIMS: The purpose of this study is to explore key genes associated with pancreatic ductal adenocarcinoma and to predict the possible mechanisms. METHODS: A weighted gene co-expression network was constructed to identify gene modules associated with the progression of PDAC...
August 16, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28815402/covered-esophageal-stenting-is-effective-for-symptomatic-gastric-lumen-narrowing-and-related-complications-following-laparoscopic-sleeve-gastrectomy
#5
Murad A Aburajab, Joshua B Max, Mel A Ona, Kapil Gupta, Miguel Burch, F Michael Feiz, Simon K Lo, Laith H Jamil
BACKGROUND AND STUDY AIMS: Laparoscopic sleeve gastrectomy (LSG) is gaining popularity in treating morbid obesity. Prior studies showed a 3.5% risk of gastric sleeve stenosis (GSS). There is no consensus on how to treat these patients, and the role of endoscopic therapy has been addressed in only a few studies. We aim to assess the efficacy and safety of endoscopic stenting in the management of GSS following LSG. PATIENTS AND METHODS: Retrospective data were reviewed from July 2009 to November 2013...
August 16, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28815354/nf-e2-related-factor-2-suppresses-intestinal-fibrosis-by-inhibiting-reactive-oxygen-species-dependent-tgf-%C3%AE-1-smads-pathway
#6
Yadi Guan, Yue Tan, Weiyu Liu, Jun Yang, Dongxu Wang, Di Pan, Yan Sun, Changqing Zheng
BACKGROUND AND AIMS: This study aimed to evaluate the antifibrotic effects of NF-E2-Related Factor 2 (Nrf2) on intestinal fibrosis. Intestinal fibrosis is a common complication of Crohn's disease; however, its mechanism of intestinal fibrosis is largely unclear. METHODS: BALB/c mice received 2,4,6-trinitrobenzene sulfonic acid weekly via intrarectal injections to induce chronic fibrotic colitis. They also diet containing received 1% (w/w) tert-butylhydroquinone (tBHQ), which is an agonist of Nrf2...
August 16, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28815353/perceptions-of-the-inpatient-training-experience-a-nationwide-survey-of-gastroenterology-program-directors-and-fellows
#7
EDITORIAL
Navin L Kumar, Molly L Perencevich, Jerry S Trier
BACKGROUND: Inpatient training is a key component of gastroenterology (GI) fellowship programs nationwide, yet little is known about perceptions of the inpatient training experience. AIM: To compare the content, objectives and quality of the inpatient training experience as perceived by program directors (PD) and fellows in US ACGME-accredited GI fellowship programs. METHODS: We conducted a nationwide, online-based survey of GI PDs and fellows at the conclusion of the 2016 academic year...
August 16, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28815349/tumor-volume-doubling-time-as-a-dynamic-prognostic-marker-for-patients-with-hepatocellular-carcinoma
#8
Jong Kwan Kim, Hyung-Don Kim, Mi-Jung Jun, Sung-Cheol Yun, Ju Hyun Shim, Han Chu Lee, Danbi Lee, Jihyun An, Young-Suk Lim, Young-Hwa Chung, Yung Sang Lee, Kang Mo Kim
BACKGROUND AND AIMS: To evaluate the clinical value of tumor growth rate in hepatocellular carcinoma (HCC) patients, we investigated the growth rate of HCC by calculating the tumor volume doubling time (TVDT) and its impact on survival and recurrence. METHODS: A retrospective cohort study of 269 HCC patients who underwent two or more pretreatment imaging studies of computed tomography or magnetic resonance imaging was performed. Tumor growth rate and TVDT were calculated by comparing tumor volumes between imaging studies...
August 16, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28815345/mosapride-stabilizes-intestinal-microbiota-to-reduce-bacterial-translocation-and-endotoxemia-in-ccl4-induced-cirrhotic-rats
#9
Hong Xu, Jingfang Xiong, Jianjun Xu, Shuiming Li, Yang Zhou, Dongya Chen, Xinjun Cai, Jian Ping, Min Deng, Jianyong Chen
BACKGROUND: Impaired intestinal motility may lead to the disruption of gut microbiota equilibrium, which in turn facilitates bacterial translocation (BT) and endotoxemia in cirrhosis. We evaluated the influence of mosapride, a prokinetic agent, on BT and DNA fingerprints of gut microbiota in cirrhotic rats. METHODS: A rat model of cirrhosis was set up via subcutaneous injection of carbon tetrachloride (CCl4). The portal pressure, liver and intestinal damage, plasma endotoxin, BT, and intestinal transit rate (ITR) of cirrhotic rats were determined...
August 16, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28791556/the-clinical-implications-of-fatty-pancreas-a-concise-review
#10
REVIEW
Tawfik Khoury, Akwi W Asombang, Tyler M Berzin, Jonah Cohen, Douglas K Pleskow, Meir Mizrahi
Fatty pancreas is a newly recognized condition which is poorly investigated until today as compared to nonalcoholic fatty liver disease. It is characterized by pancreatic fat accumulation and subsequent development of pancreatic and metabolic complications. Association of fatty pancreas have been described with type 2 diabetes mellitus, acute and chronic pancreatitis and even pancreatic carcinoma. In this review article, we provide an update on clinical implications, pathogenesis, diagnosis, treatment and outcomes...
August 8, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28785916/hepatic-dysfunction-in-renal-cell-carcinoma-not-what-you-think
#11
Anas Gremida, Ahmad Al-Taee, Joseph Alcorn, Denis McCarthy
No abstract text is available yet for this article.
August 7, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28780610/pancreatic-leaks-and-fistulae-an-endoscopy-oriented-classification
#12
REVIEW
Massimiliano Mutignani, Stefanos Dokas, Alberto Tringali, Edoardo Forti, Francesco Pugliese, Marcello Cintolo, Raffaele Manta, Lorenzo Dioscoridi
BACKGROUND: Pancreatic leaks occur as a complication of upper gastrointestinal surgery, acute pancreatitis, or abdominal trauma. Pancreatic fistulas and leaks are primarily managed conservatively. Overall, conservative measures are successful in more than half of cases. Whenever conservative treatment is not efficient, surgery is usually considered the treatment of choice. Nowadays however, endoscopic treatment is being increasingly considered and employed in many cases, as a surgery sparing intervention...
August 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28780609/unstable-housing-still-a-barrier-to-receiving-hcv-treatment-in-france-anrs-co13-hepavih-cohort
#13
LETTER
I Yaya, P Roux, F Marcellin, D Salmon-Ceron, M P Carrieri
No abstract text is available yet for this article.
August 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28780608/sx-ella-stent-danis-effectively-controls-refractory-variceal-bleed-in-patients-with-acute-on-chronic-liver-failure
#14
Rakhi Maiwall, Kapil Dev Jamwal, Ankit Bhardwaj, Ajeet Singh Bhadoria, Jaswinder Singh Maras, Guresh Kumar, Ankur Jindal, Ashok Choudhury, Lovkesh Anand, Amrish Sahney, Awinash Kumar, Manoj Kumar Sharma, Barjesh Chander Sharma, Shiv Kumar Sarin
BACKGROUND AND AIMS: Almost 10% of bleeding episodes are refractory to combination of vasoactive agent and endotherapy, and are associated with a mortality up to 50%. Severity of liver disease and high portal pressure are mainly responsible for it. TIPS cannot be used in these patients due to high MELD score. We aimed to evaluate the efficacy of self-expandable DE stents for control of refractory variceal bleeds in patients with ACLF. METHODS: Acute-on-chronic liver failure patients (n = 88, mean age 47...
August 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28780607/strategies-to-identify-and-reduce-opioid-misuse-among-patients-with-gastrointestinal-disorders-a-systematic-scoping-review
#15
REVIEW
Salva N Balbale, Itishree Trivedi, Linda C O'Dwyer, Megan C McHugh, Charlesnika T Evans, Neil Jordan, Laurie A Keefer
BACKGROUND: Scoping reviews are preliminary assessments intended to characterize the extent and nature of emerging research evidence, identify literature gaps, and offer directions for future research. We conducted a systematic scoping review to describe published scientific literature on strategies to identify and reduce opioid misuse among patients with gastrointestinal (GI) symptoms and disorders. METHODS: We performed structured keyword searches to identify manuscripts published through June 2016 in the PubMed MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science databases to extract original research articles that described healthcare practices, tools, or interventions to identify and reduce opioid misuse among GI patients...
August 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28780606/therapeutic-potential-of-the-gabaergic-system-in-ulcerative-colitis-current-status-and-perspectives
#16
EDITORIAL
Maria Grazia Zizzo, Rosa Serio
No abstract text is available yet for this article.
August 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28776143/th1-pathway-the-missing-link-between-inflammatory-bowel-disease-and-microscopic-colitis
#17
EDITORIAL
Anna Carrasco, Fernando Fernández-Bañares
No abstract text is available yet for this article.
August 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28776142/understanding-the-differences-between-gastroparesis-and-gastroparesis-like-syndrome-filling-a-gaping-hole
#18
EDITORIAL
Jonathan Gotfried, Ron Schey
No abstract text is available yet for this article.
August 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28776141/vonoprazan-based-helicobacter-pylori-eradication-therapy-time-to-get-kompetitive
#19
EDITORIAL
Eun Hye Kim, Chan Hyuk Park
No abstract text is available yet for this article.
August 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28776140/biosimilar-drugs-for-inflammatory-bowel-disease-is-similar-good-enough
#20
EDITORIAL
Mariangela Allocca, Gionata Fiorino, Silvio Danese
No abstract text is available yet for this article.
August 3, 2017: Digestive Diseases and Sciences
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