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Digestive Diseases and Sciences

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https://www.readbyqxmd.com/read/28721575/gastroparesis-medical-and-therapeutic-advances
#1
REVIEW
Christopher M Navas, Nihal K Patel, Brian E Lacy
Gastroparesis is a chronic, bothersome, and often disabling neuromuscular disorder of the upper gastrointestinal tract. The most frequently reported symptoms of gastroparesis include nausea, vomiting, epigastric pain, early satiety, and unintentional weight loss. Etiologies of gastroparesis include diabetes, connective tissue disorders, prior infection, mesenteric ischemia, and post-surgical complications. The largest category of gastroparesis patients is comprised of those in whom no definitive cause can be identified (idiopathic gastroparesis)...
July 18, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28717845/proteomics-in-inflammatory-bowel-disease-approach-using-animal-models
#2
REVIEW
Fadi H Mourad, Yunki Yau, Valerie C Wasinger, Rupert W Leong
Recently, proteomics studies have provided important information on the role of proteins in health and disease. In the domain of inflammatory bowel disease, proteomics has shed important light on the pathogenesis and pathophysiology of inflammation and has contributed to the discovery of some putative clinical biomarkers of disease activity. By being able to obtain a large number of specimens from multiple sites and control for confounding environmental, genetic, and metabolic factors, proteomics studies using animal models of colitis offered an alternative approach to human studies...
July 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28717844/application-of-the-biopsy-sparing-espghan-guidelines-for-celiac-disease-diagnosis-in-adults-a-real-life-study
#3
Konstantinos Efthymakis, Mariaelena Serio, Angelo Milano, Francesco Laterza, Antonella Bonitatibus, Marta Di Nicola, Matteo Neri
BACKGROUND: Current adult celiac disease diagnosis requires histological confirmation. However, pediatric guidelines have proposed biopsy-sparing algorithms. AIMS: To explore the applicability of the ESPGHAN criteria and assess the accuracy of serology in predicting disease in adults. METHODS: We evaluated 234 consecutive adults showing elevated anti-tTG titers, EMA-positivity, and genetic susceptibility. Patients underwent upper endoscopy with duodenal biopsy...
July 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28710658/global-disparities-and-their-implications-in-the-occurrence-and-outcome-of-autoimmune-hepatitis
#4
REVIEW
Albert J Czaja
Autoimmune hepatitis has a variable occurrence, clinical phenotype, and outcome, and the factors contributing to this variability are uncertain. The goals of this review are to examine the global disparities in the occurrence and outcome of autoimmune hepatitis, suggest bases for these disparities, and encourage investigations that extend beyond single-center experiences. Disparities in the incidence and prevalence of autoimmune hepatitis in different age groups, genders, ethnicities, and geographical regions suggest that factors other than genetic predisposition are involved...
July 14, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28702754/endoscopic-cyanoacrylate-injection-with-post-injection-audible-doppler-assessment-of-gastric-varices-a-single-institution-experience
#5
Tom D Catron, George B Smallfield, Le Kang, Richard K Sterling, Mohammad S Siddiqui
BACKGROUND AND AIMS: Gastric varices (GV) have higher rates of morbidity and mortality from hemorrhage than esophageal varices. Several studies have shown the safety and efficacy of cyanoacrylate (CA) injection for acute gastric variceal hemorrhage. We report data from our experience with CA injection for GV before and after routine use of post-injection audible Doppler assessment (ADA) for GV obturation and describe long-term outcomes after this therapy. METHODS: We retrospectively identified patients who had documented GV, underwent CA injection, and had at least 2 weeks of follow-up...
July 12, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28702753/magnifying-nbi-patterns-of-gastric-mucosa-after-helicobacter-pylori-eradication-and-its-potential-link-to-the-gastric-cancer-risk
#6
Tomomitsu Tahara, Sayumi Tahara, Tetsuya Tuskamoto, Noriyuki Horiguchi, Dai Yoshida, Tomohiko Kawamura, Masaaki Okubo, Mitsuo Nagasaka, Yoshihito Nakagawa, Makoto Urano, Makoto Kuroda, Tomoyuki Shibata, Naoki Ohmiya
BACKGROUND: Gastric cancer develops after successful H. pylori eradication in patients with severe atrophic gastritis. We classified atrophic and non-atrophic mucosa of gastric body using magnifying NBI endoscopy in patients after successful H. pylori eradication. MATERIALS AND METHODS: One hundred and twenty-five patients after successful H. pylori eradication (median period after eradication: 36 months) were enrolled. Magnifying NBI patterns in the uninvolved gastric body were divided into the following: restored-small, round pits, accompanied with honeycomb-like subepithelial capillary networks; atrophic-well-demarcated oval or tubulovillous pits with clearly visible coiled or wavy vessels...
July 12, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28689252/erratum-to-the-validity-of-a-new-structured-assessment-of-gastrointestinal-symptoms-scale-sagis-for-evaluating-symptoms-in-the-clinical-setting
#7
N A Koloski, M Jones, J Hammer, M von Wulffen, A Shah, H Hoelz, M Kutyla, D Burger, N Martin, S R Gurusamy, N J Talley, G Holtmann
No abstract text is available yet for this article.
July 8, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28687943/symptoms-of-functional-intestinal-disorders-are-common-in-patients-with-celiac-disease-following-transition-to-a-gluten-free-diet
#8
Jocelyn A Silvester, Lesley A Graff, Lisa Rigaux, Charles N Bernstein, Daniel A Leffler, Ciarán P Kelly, John R Walker, Donald R Duerksen
BACKGROUND: Celiac disease and functional intestinal disorders may overlap, yet the natural history of functional symptoms in patients with celiac disease is unknown. AIM: To investigate the prevalence of irritable bowel syndrome (IBS), functional dyspepsia (FD), and functional bloating (FB) symptoms among patients with celiac disease at diagnosis and during the first year of a gluten-free diet. METHODS: Adults with a new diagnosis of celiac disease were surveyed at baseline, 6 months and 1 year using standardized measures for intestinal symptoms [Rome III diagnostic questionnaire and celiac symptom index (CSI)] and gluten-free diet adherence [gluten-free eating assessment tool (GF-EAT) and celiac diet adherence test]...
July 7, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28687942/rare-duodenal-varix-coil-erosion-post-tips-creation-and-coil-embolization-of-mesenteric-systemic-shunt
#9
Matthew P Soape, Andrew Lichliter, Marco Cura, Maria R Lepe-Suastegui, J Steven Burdick
No abstract text is available yet for this article.
July 7, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28681083/a-novel-protocol-obviates-endoscope-sampling-for-carbapenem-resistant-enterobacteriaceae-experience-of-a-center-with-a-prior-outbreak
#10
Zachary L Smith, Arshish Dua, Kia Saeian, Nathan A Ledeboer, Mary Beth Graham, Murad Aburajab, Darren D Ballard, Abdul H Khan, Kulwinder S Dua
BACKGROUND: Numerous published outbreaks, including one from our institution, have described endoscope-associated transmission of multidrug-resistant organisms (MDROs). Individual centers have adopted their own protocols to address this issue, including endoscope culture and sequestration. Endoscope culturing has drawbacks and may allow residual bacteria, including MDROs, to go undetected after high-level disinfection. AIM: To report the outcome of our novel protocol, which does not utilize endoscope culturing, to address our outbreak...
July 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28676901/does-metabolic-syndrome-and-not-the-inflammatory-load-predict-nonalcoholic-fatty-liver-disease-severity-in-inflammatory-bowel-disease-patients
#11
LETTER
Alessandro Sartini, Stefano Gitto, Erica Villa
No abstract text is available yet for this article.
July 4, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28667432/evaluation-of-the-international-consensus-guidelines-for-the-surgical-resection-of-intraductal-papillary-mucinous-neoplasms
#12
Mariko Tsukagoshi, Kenichiro Araki, Fumiyoshi Saito, Norio Kubo, Akira Watanabe, Takamichi Igarashi, Norihiro Ishii, Takahiro Yamanaka, Ken Shirabe, Hiroyuki Kuwano
BACKGROUND: International consensus guidelines for intraductal papillary mucinous neoplasms (IPMNs) were revised in 2012. AIMS: We aimed to evaluate the clinical utility of each predictor in the 2006 and 2012 guidelines and validate the diagnostic value and surgical indications. METHODS: Forty-two patients with surgically resected IPMNs were included. Each predictor was applied to evaluate its diagnostic value. RESULTS: The 2012 guidelines had greater accuracy for invasive carcinoma than the 2006 guidelines (64...
June 30, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28667431/increase-in-hospital-discharges-for-inflammatory-bowel-diseases-in-chile-between-2001-and-2012
#13
Felipe Bellolio Roth, Javier Gómez, Jaime Cerda
AIM: To determine the number of annual hospital discharges for inflammatory bowel diseases in Chile. The hypothesis is that there is a significant increase in the hospital discharges due to this disease from 2001 to 2012. MATERIALS AND METHODS: This is a descriptive study. Data were obtained from the Web site of the Department of Health Statistics. All hospital discharges from 2001 to 2012 were included. The following variables were analyzed: length of stay, hospital mortality, and eventual surgical procedure...
June 30, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28667430/attenuated-gabaergic-signaling-in-intestinal-epithelium-contributes-to-pathogenesis-of-ulcerative-colitis
#14
Surbhi Aggarwal, Vineet Ahuja, Jaishree Paul
BACKGROUND: Neuromediators produced by enteric nervous system regulate inflammatory processes via interacting with enteric immune system. Role of γ-aminobutyric acid (GABA), which is also a neuromediator, has been implicated in autoimmune diseases like multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, where they modulate the immune responses. However, its role in ulcerative colitis (UC) has not been defined. AIMS: This study was carried out to investigate the role of GABA and its signaling components in pathogenesis of UC...
June 30, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28667429/long-term-clinical-outcomes-after-switching-from-remicade-%C3%A2-to-biosimilar-ct-p13-in-inflammatory-bowel-disease
#15
Lisa J T Smits, Anna Grelack, Lauranne A A P Derikx, Dirk J de Jong, Aura A J van Esch, Ronald S Boshuizen, Joost P H Drenth, Frank Hoentjen
BACKGROUND: Limited data are available on long-term clinical outcomes regarding the switch from Remicade(®) to the infliximab biosimilar CT-P13 in inflammatory bowel disease (IBD) patients. AIMS: To investigate long-term efficacy, safety, pharmacokinetic profile, and immunogenicity. METHODS: We performed a single-center prospective observational cohort study following an elective switch from Remicade(®) to CT-P13 in IBD patients. RESULTS: Eighty-three patients were included (57 Crohn's disease, 24 ulcerative colitis, and 2 IBD unclassified), and 68 patients completed one-year follow-up...
June 30, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28664410/efficacy-of-vonoprazan-based-triple-therapy-for-helicobacter-pylori-eradication-a-multicenter-study-and-a-review-of-the-literature
#16
Hiroki Tanabe, Katsuyoshi Ando, Kiichi Sato, Takahiro Ito, Mitsuru Goto, Tomonobu Sato, Akihiro Fujinaga, Toru Kawamoto, Tatsuya Utsumi, Nobuyuki Yanagawa, Eiichiro Ichiishi, Takaaki Otake, Yutaka Kohgo, Yoshiki Nomura, Nobuhiro Ueno, Hiroko Sugano, Shin Kashima, Kentaro Moriichi, Mikihiro Fujiya, Toshikatsu Okumura
BACKGROUND: Eradication therapies for Helicobacter pylori infection are advancing as new acid inhibitory reagents approved. The aim of this study was to assess the efficacy and safety of vonoprazan-based triple treatment. MATERIALS AND METHODS: Triple therapy with vonoprazan and two antibiotics (amoxicillin and clarithromycin or metronidazole) received focus in this analysis. We performed a multicenter retrospective study of patients who received vonoprazan-based eradication therapy between February 2015 and February 2016 and conducted a review of the literature...
June 29, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28646286/rifaximin-re-treatment-in-patients-with-irritable-bowel-syndrome-feels-like-the-first-time
#17
EDITORIAL
Francesca Romana Ponziani, Maurizio Pompili, Antonio Gasbarrini
No abstract text is available yet for this article.
June 23, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28646285/growing-concerns-a-3-year-old-girl-with-multiple-hepatic-masses-and-gastrointestinal-bleeding
#18
Christine Yang, Adam Gomez, Anshul Haldipur, William Berquist, Dorsey Bass
No abstract text is available yet for this article.
June 23, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28646284/chd1l-expression-increases-tumor-progression-and-acts-as-a-predictive-biomarker-for-poor-prognosis-in-pancreatic-cancer
#19
Chuan Liu, Xiaowei Fu, Zhiwei Zhong, Jing Zhang, Haiyan Mou, Qiong Wu, Tianle Sheng, Bo Huang, Yeqing Zou
BACKGROUND: The chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) plays a key role in controlling various cellular phenomena, including immune-mediated inflammation, transformation, apoptosis, cell cycle progression, and proliferation. METHODS: This study investigated the function and clinical significance of CHD1L protein expression in pancreatic cancer (PC). We analyzed CHD1L expression in surgical specimens from 112 PC patients. The correlation between the clinical characteristics and prognosis was also determined...
June 23, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28646283/cd4-t-cells-in-ibd-crossing-the-line
#20
EDITORIAL
Elisa K Boden, James D Lord
No abstract text is available yet for this article.
June 23, 2017: Digestive Diseases and Sciences
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