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Digestive Diseases and Sciences

Stefan Seewald, Tiing Leong Ang, Roos E Pouw, Fridolin Bannwart, Jacques J Bergman
Barrett's esophagus with high-grade dysplasia and early-stage adenocarcinoma is amenable to curative treatment by endoscopic resection. Histopathological correlation has established that mucosal cancer has minimal risk of nodal metastases and that long-term complete remission can be achieved. Although surgery is the gold-standard treatment once there is submucosal involvement, even T1sm1 (submucosal invasion ≤ 500 μm) cases without additional risk factors for nodal metastases might also be cured with endoscopic resection...
June 23, 2018: Digestive Diseases and Sciences
Ryan Howard, David Machado-Aranda
No abstract text is available yet for this article.
June 23, 2018: Digestive Diseases and Sciences
Shouhua Zhang, Yuanqi Gong, Juhua Xiao, Yong Chai, Jun Lei, Hui Huang, Tianxin Xiang, Wei Shen
BACKGROUND: Soluble TGF-β1 type II receptor (sTβRII) via TGF-β1 inhibition could inhibit hepatic fibrosis, but over-dosage triggers autoimmune responses. AIM: To test whether the use of a TGF-β1-responsive collagen I promoter COL1A1, via generating a feedback loop to TGF-β1 level, could offer accurate control on sTβRII expression. METHODS: Recombinant adenoviruses with COL1A1 (Ad-COL-sTβRII/Luc) or CMV promoter (Ad-CMV-sTβRII/Luc) were constructed and characterized...
June 23, 2018: Digestive Diseases and Sciences
Itaru Naitoh, Yasuki Hori
No abstract text is available yet for this article.
June 23, 2018: Digestive Diseases and Sciences
Adrienne Lenhart, Salwa Hussain, Reena Salgia
BACKGROUND: Acute kidney injury in the setting of alcoholic liver disease portends a poor prognosis without liver transplant. AIMS: Using a tertiary care population, we aimed to evaluate the outcomes of renal replacement therapy in patients with alcoholic liver disease and acute kidney injury with < 6 months sobriety. METHODS: A retrospective review of hospitalized patients with alcoholic hepatitis/acute on chronic alcoholic cirrhosis and hepatorenal syndrome or acute tubular necrosis was performed...
June 22, 2018: Digestive Diseases and Sciences
Huohui Ou, Yu Huang, Leyang Xiang, Zhanjun Chen, Yinghao Fang, Yixiong Lin, Zhonglin Cui, Sheng Yu, Xianghong Li, Dinghua Yang
BACKGROUND: Circulating tumors cells (CTCs) may be a promising prognostic marker for patients with malignant tumors. However, there are few reports regarding its value for hepatocellular carcinoma (HCC) patients. AIMS: To investigate CTCs with epithelial and mesenchymal phenotypes as a potential prognostic biomarker for HCC patients. METHODS: Peripheral blood samples were obtained from 165 HCC patients before radical surgery. CTCs were isolated via the CanPatrol CTC enrichment technique and classified using epithelial-mesenchymal transition (EMT) markers...
June 21, 2018: Digestive Diseases and Sciences
C Roberto Simons-Linares, Jodie A Barkin, Yuchen Wang, Palashkumar Jaiswal, William Trick, Michael J Bartel, Jamie S Barkin
BACKGROUND AND AIM: Twenty-percentage of acute pancreatitis (AP) cases is labeled as idiopathic. Cannabis remains the most frequently used illicit drug in the world. The aim of this study was to identify the prevalence of cannabis use among all patients with a first episode of AP, particularly in those labeled as idiopathic etiology, and determine any effect on AP severity. METHODS: Retrospective cohort of all consecutive patients admitted with a first episode of AP at a large tertiary referral hospital from 01/2013 through 12/2014...
June 20, 2018: Digestive Diseases and Sciences
Ernst J Kuipers, Manon C Spaander
Barrett's esophagus (BE) is a very common condition. We have obtained fairly profound knowledge of the natural history of this condition. This results from many cross-sectional and cohort studies, many describing patients undergoing long-term surveillance. Their consent to use their clinical data has improved our knowledge to the benefit of these same and other patients. The prevalence of BE increases with age both in men and in women. This increase starts at a younger age in men than in women. The incidence of high-grade dysplasia and cancer in BE depends on segment length, gender, and age...
June 15, 2018: Digestive Diseases and Sciences
Ji-Hong Chen, Jan D Huizinga
No abstract text is available yet for this article.
June 7, 2018: Digestive Diseases and Sciences
Georgios I Tsiaoussis, Eleni C Papaioannou, Eleni P Kourea, Stelios F Assimakopoulos, Georgios I Theocharis, Michalis Petropoulos, Vasileios I Theopistos, Georgia G Diamantopoulou, Zoi Lygerou, Iris Spiliopoulou, Konstantinos C Thomopoulos
AIM: The present study investigates the role of innate and adaptive immune system of intestinal mucosal barrier function in cirrhosis. METHODS: Forty patients with decompensated (n = 40, group A), 27 with compensated cirrhosis (n = 27, group B), and 27 controls (n = 27, group C) were subjected to duodenal biopsy. Expression of α-defensins 5 and 6 at the intestinal crypts was evaluated by immunohistochemistry and immunofluorescence. Serum endotoxin, intestinal T-intraepithelial, and lamina propria B-lymphocytes were quantified...
June 7, 2018: Digestive Diseases and Sciences
Shirley Cohen-Mekelburg, Stephanie Gold, Yecheskel Schneider, Madison Dennis, Clara Oromendia, Heather Yeo, Fabrizio Michelassi, Ellen Scherl, Adam Steinlauf
BACKGROUND: Studies have shown that prophylactic biologic therapy can reduce post-surgical Crohn's disease recurrence. AIMS: We aimed to identify the frequency of delay and risk factors associated with a delay in the initiation of prophylactic post-surgical biologic therapy in high-risk patients. METHODS: We performed a cohort study of Crohn's disease patients who underwent a bowel resection. We identified those at risk of recurrence and explored multiple characteristics for those with and without a delay post-operatively...
June 7, 2018: Digestive Diseases and Sciences
Jin Young Yoon, Jae Myung Cha, Ju Kyoung Oh, Pei Lei Tan, Sae Hun Kim, Min Seob Kwak, Jung Won Jeon, Hyun Phil Shin
BACKGROUND/AIMS: The efficacy of probiotics for improving clinical symptoms, altering the fecal microbiota, and regulating serum immune cytokine levels was investigated in patients with irritable bowel syndrome-constipation (IBS-C) or functional constipation (FC). METHODS: A randomized, double-blind, placebo-controlled trial was conducted at Kyung Hee University Hospital between October 2016 and February 2017. Consecutive 18-75-year-old patients with diagnosis of IBS-C or FC (based on Rome IV criteria) consumed probiotics (3...
June 7, 2018: Digestive Diseases and Sciences
Yunho Jung, Jong Wook Kim, Jeong-Sik Byeon, Hoon Sup Koo, Sun-Jin Boo, Jun Lee, Young Hwangbo, Yoon Mi Jeen, Hyun Gun Kim
BACKGROUND: Endoscopic submucosal dissection (ESD) with snaring (hybrid ESD) bridges the gap between ESD and endoscopic mucosal resection. We evaluated factors predictive of en bloc and complete resection of large colorectal neoplasms using hybrid ESD. METHODS: This was a prospective clinical study of 78 patients who underwent hybrid ESD for excision of colorectal neoplasms (≥ 2 cm) between May 2015 and September 2016 at six university hospitals. We evaluated lesion and patient characteristics, endoscopist experience level (< 50 or ≥ 50 cases with colorectal ESD), and technical factors such as concurrent fibrosis, completion of a circumferential incision, degree of submucosal dissection (< 50 or ≥ 50%), and visualization during snaring (< 50 or ≥ 50%)...
June 7, 2018: Digestive Diseases and Sciences
Andrew J Read, Michael D Rice, Hari S Conjeevaram, Sameer D Saini
BACKGROUND: Although there are guidelines for video capsule endoscopy (VCE) and device-assisted enteroscopy (DAE), little is known about fellowship training in these technologies. AIMS: The aims were to better characterize current small bowel endoscopy training in 3-year GI fellowship programs and 4th-year advanced endoscopy programs in the U.S. METHODS: We developed an online multiple-choice survey to assess current GI fellowship program training in small bowel endoscopy...
June 5, 2018: Digestive Diseases and Sciences
Seema A Patil, Raymond K Cross
No abstract text is available yet for this article.
June 4, 2018: Digestive Diseases and Sciences
Peiqi Wang, Jun Hu, Shadi Ghadermarzi, Ali Raza, Douglas O'Connell, Amy Xiao, Faraz Ayyaz, Min Zhi, Yuanqi Zhang, Nimisha K Parekh, Mark Lazarev, Alyssa Parian, Steven R Brant, Marshall Bedine, Brindusa Truta, Pinjin Hu, Rupa Banerjee, Susan M Hutfless
BACKGROUND: Cigarette smoking is thought to increase the risk of Crohn's disease (CD) and exacerbate the disease course, with opposite roles in ulcerative colitis (UC). However, these findings are from Western populations, and the association between smoking and inflammatory bowel disease (IBD) has not been well studied in Asia. AIMS: We aimed to compare the prevalence of smoking at diagnosis between IBD cases and controls recruited in China, India, and the USA, and to investigate the impact of smoking on disease outcomes...
June 4, 2018: Digestive Diseases and Sciences
Dale Lee, C Kaiulani Swan, David Suskind, Ghassan Wahbeh, Jairam Vanamala, Robert N Baldassano, Mary B Leonard, Johanna W Lampe
OBJECTIVE: Certain food additives may promote the pathogenesis of Crohn's disease (CD), but thus far the evaluation of food additive exposures in humans has been limited. The objective of this study was to quantify food additive exposures in children with CD. METHODS: In a trial for bone health in CD, children were followed over 24 months with evaluation of disease characteristics, dietary intake, and body composition. At baseline, participants completed three 24-h dietary recalls...
June 4, 2018: Digestive Diseases and Sciences
Omar Vergara-Fernández, Fredy Chablé-Montero, Natllely Ruiz, David Mitre-Reyes, Eduardo Cerda-Contreras, Andrea Hernández, Erika Marroquín-Fabián, Luis Felipe Flores-Suárez
No abstract text is available yet for this article.
June 4, 2018: Digestive Diseases and Sciences
Allen A Lee, William L Hasler
No abstract text is available yet for this article.
May 31, 2018: Digestive Diseases and Sciences
Sammy Au, Vladimir Marquez, Fergal Donnellan, Baljinder S Salh, Michael Nimmo, Karen J Goddard, Majid Alsahafi, Nazira Chatur
BACKGROUND: Cancer survivors treated with abdominal or pelvic radiation therapy (RT) for childhood cancer have an increased risk of colorectal cancer. However, clinical guidelines are inconsistent on recommendations regarding the early initiation of screening in these patients due to the lack of supporting evidence that these patients pass through a pre-invasive phase, in which adenomatous polyps can be detected and removed. AIMS: To determine the prevalence of adenomatous polyps in cancer survivors treated with RT for childhood cancer; the prevalence in average-risk patients aged 17-49; and the prevalence in average-risk patients aged 50-75...
May 31, 2018: Digestive Diseases and Sciences
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