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Digestive Diseases and Sciences

Yuan Liu, Wenbo Wang, Ziying Zou, Zonghai Hu, Quanshui Fan, Jie Xiong
BACKGROUND: Hepatitis C virus (HCV) has been classified as a strictly hepatotropic pathogen for a long time, and hepatocytes are target cells for HCV infection. More and more studies showed non-liver cells supported HCV entry and replication, such as macrophages. The mechanisms of HCV entry into macrophages are still not clear. AIMS: This study aims to determine the way of HCV entry into macrophages. METHODS: Cell culture-derived infectious HCV particles (HCVcc) were prepared using Huh7 cells transfected with HCV RNA...
December 10, 2018: Digestive Diseases and Sciences
Priyanka Chugh, Tyson Collazo, Brad Dworkin, Daniela Jodorkovsky
BACKGROUND: Ineffective esophageal motility (IEM) is defined as a distal contractile integral < 450 mmHg/s/cm in at least 50% of ten liquid swallows on high-resolution esophageal manometry (HREM). Whether this latest definition correlates with degree of symptoms has not been studied. METHODS: Patients presenting for HREM prospectively rated their symptoms using the Eckardt score. Topography plots were retrospectively reviewed and classified according to the latest Chicago Classification...
December 10, 2018: Digestive Diseases and Sciences
Thomas Sommers, Travis Petersen, Prashant Singh, Vikram Rangan, William Hirsch, Jesse Katon, Sarah Ballou, Vivian Cheng, Daniel Friedlander, Judy Nee, Anthony Lembo, Johanna Iturrino
BACKGROUND: Fecal impaction (FI) is defined as a large mass of stool in the rectum and/or colon that is unable to be evacuated. No study to date details demographics and outcomes in a sizeable sample of FI patients in the USA. AIMS: The present study aims to develop knowledge of FI by reporting descriptive measures and outcomes of patients presenting to a US emergency department (ED) with FI. METHODS: Medical charts coded with FI at Beth Israel Deaconess Medical Center from 2016 or 2017 were identified retrospectively...
December 8, 2018: Digestive Diseases and Sciences
S Sebastian, S Myers, S Nadir, S Subramanian
BACKGROUND: Pharmacokinetic data suggest that standard induction dosing schedules may not be sufficient in patients with acute severe colitis (ASUC). Hence, intensified induction regimes are increasingly used in the rescue treatment of hospitalized patients with ASUC to avoid the need for colectomy although the evidence for this is uncertain. AIM: To conduct a systematic review of short- and long-term efficacy outcomes from accelerated infliximab induction studies...
December 7, 2018: Digestive Diseases and Sciences
V Mitsialis, Y Wu, B Gewurz, R Bleday, L A Doyle, R W Winter, M J Hamilton
No abstract text is available yet for this article.
December 7, 2018: Digestive Diseases and Sciences
Yu-Feng Qi, Jun-Ning Sun, Lai-Feng Ren, Xue-Ling Cao, Jian-Hong Dong, Kai Tao, Xue-Mei Guan, Ya-Ni Cui, Wen Su
BACKGROUND: Many diseases have been associated with intestinal microbial dysbiosis. Host-microbial interactions regulate immune function, which influences the development of gastric cancer. AIMS: The aims were to investigate the characteristics of intestinal microbiota composition in gastric cancer patients and correlations between the intestinal microbiota and cellular immunity. METHODS: Fecal samples were collected from 116 gastric cancer patients and 88 healthy controls from Shanxi Province, China...
December 7, 2018: Digestive Diseases and Sciences
Nikolas Plevris, Gareth R Jones, Philip W Jenkinson, Mathew Lyons, Cher S Chuah, Lynne M Merchant, Rebecca J Pattenden, Eleanor F Watson, Gwo-Tzer Ho, Colin L Noble, Shahida Din, Alan G Shand, Ian D Arnott, Charlie W Lees
BACKGROUND: Switching from Remicade to CT-P13 allows for significant cost savings and has been shown to be non-inferior to continued therapy with Remicade for the treatment of Crohn's disease. AIM: The aim of this work was to prospectively evaluate clinical outcomes in a cohort of patients with Crohn's disease switching from Remicade to CT-P13. METHODS: A prospective service evaluation was performed. The Harvey-Bradshaw index, CRP, faecal calprotectin and serum for infliximab/antibody levels were collected prior to patients' final Remicade infusion and at 6 and 12 months after switching to CT-P13 as part of routine clinical care...
December 7, 2018: Digestive Diseases and Sciences
Sara M Lewin, Kwun Wah Wen, Fernando S Velayos, Uma Mahadevan, Kendall R Beck
No abstract text is available yet for this article.
December 7, 2018: Digestive Diseases and Sciences
Reena Kumari, Senthilnathan Palaniyandi, Gerhard Carl Hildebrandt
Hematopoietic cell transplantation is an intensive therapy used to treat high-risk hematological malignant disorders and other life-threatening hematological and genetic diseases. Graft-versus-host disease (GVHD) presents a barrier to its wider application. A conditioning regimen and medications given to patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HCT) are capable of disturbing the homeostatic crosstalk between the microbiome and the host immune system and of leading to dysbiosis...
December 7, 2018: Digestive Diseases and Sciences
Mohamed Tausif Siddiqui, Mohammad Bilal, Lakshmi Asritha Gollapudi, Dhruv Mehta, Shifa Umar, Jonathan Barsa, Christopher Nabors, Beth Schorr-Lesnick, Edward Lebovics, Virendra Tewari
BACKGROUND: Gastrointestinal hemorrhage (GIH) is reported to occur in 1-8% of patients admitted with acute ischemic stroke (AIS). AIS is considered to be a relative contraindication to GIE. AIMS: Evaluate the outcomes of gastrointestinal endoscopy (GIE) in patients hospitalized with AIS and GIH. METHODS: Patients hospitalized with AIS and GIH were included from the National Inpatient Sample 2005-2014. Primary outcome measure was in-hospital mortality in patients with AIS and GIH who underwent gastrointestinal endoscopy...
December 5, 2018: Digestive Diseases and Sciences
Qian Wang, Qian Zhang, Handong Sun, Weiwei Tang, Lili Yang, Zhipeng Xu, Zhihua Liu, Hui Jin, Xiufeng Cao
BACKGROUND: Circular RNAs (circRNAs), a special class of noncoding RNAs with the characteristic of covalent closed-loop structure, have been widely found in various organisms. Growing evidence has shown that circRNAs play a crucial role in regulating biological functions of cancers. However, the specific role of circRNAs in esophageal squamous cell carcinoma (ESCC) remains largely unknown. AIM: The present study aims to investigate the effects of circ-TTC17 in ESCC clinical samples as well as cells...
December 5, 2018: Digestive Diseases and Sciences
Mohannad Abou Saleh, Emad Mansoor, Mohammad Anindo, Gerard Isenberg
BACKGROUND AND AIMS: Most carcinoid tumors of the gastrointestinal tract are located in the small bowel (SB). Epidemiological studies of these tumors have been limited by small sample sizes. Our aim was to evaluate the epidemiology of SB carcinoids (SBCs) using a large database. METHODS: We queried a commercial database (Explorys), an aggregate of electronic health data from 26 US healthcare systems. We identified patients with SBCs between 2012 and 2017. We evaluated the epidemiology of SBC and identified possible risk factors...
December 5, 2018: Digestive Diseases and Sciences
Diego Almanza, Mehrnaz Gharaee-Kermani, Alisa Zhilin-Roth, Jose A Rodriguez-Nieves, Cory Colaneri, Todd Riley, Jill A Macoska
BACKGROUND: Metabolic syndrome contributing to nonalcoholic fatty liver disease (NAFLD) can lead to hepatic dysfunction, steatohepatitis, cirrhosis, and hepatocellular carcinoma. AIMS: In this study, we tested whether diet-induced fatty liver in a mouse model physiologically mimicked human NAFLD, and whether transcriptional alterations in mouse fatty liver signified risk for the development of hepatitis, cirrhosis, and/or hepatocellular carcinoma. METHODS: SAMP6 strain mice were fed a low-fat diet or high-fat diet (HFD) for 6 months...
December 5, 2018: Digestive Diseases and Sciences
Sammy Saab, Satvir S Saggi, Mizna Akbar, Gina Choi
BACKGROUND: There is currently an inadequate supply of allografts to meet the number of transplant candidates worldwide. A number of controversial policies, including implementation of a presumed consent organ donation system, have been considered to rectify the organ donation crisis. AIMS: A secondary retrospective data analysis aimed to assess the impact of switching to a presumed consent organ donation model on organ donation rates. METHODS: Deceased organ donation rates were compared before and after countries adopted presumed consent...
December 5, 2018: Digestive Diseases and Sciences
Long B Le, Harman K Rahal, Matthew R Viramontes, Katherine G Meneses, Tien S Dong, Sammy Saab
BACKGROUND: Post-liver transplantation care is limited to tertiary care centers. Concentration at expert centers leads to high-volume clinics with long wait times and decreased accessibility. AIM: To assess whether telemedicine can be utilized to overcome barriers to care while sustaining strong patient-physician relationships. METHODS: The Patient Satisfaction Questionnaire-18, Telemedicine Satisfaction Questionnaire, and Health Utilization Questionnaire were used to assess patient satisfaction and healthcare utilization among patients who received care via video connection (telemedicine group) and in clinic (control group)...
December 5, 2018: Digestive Diseases and Sciences
Jessica R Allegretti, Monika Fischer, Sashidhar V Sagi, Matthew E Bohm, Hala M Fadda, Sejal R Ranmal, Shrish Budree, Abdul W Basit, Dean L Glettig, Eva L de la Serna, Amanda Gentile, Ylaine Gerardin, Sonia Timberlake, Rotem Sadovsky, Mark Smith, Zain Kassam
BACKGROUND: Fecal microbiota transplantation (FMT) is an effective therapy for recurrent Clostridium. difficile infection (rCDI). FMT capsules have emerged, and it is unknown if delivery location and dose impact efficacy. METHODS: We compared two cohorts of patients receiving two capsule formulations: gastric release (FMTgr) and targeted colonic release (FMTcr) at two different sites. Cohort A received FMTgr at (1) high dose: 60 capsules and low dose: 30 capsules...
December 5, 2018: Digestive Diseases and Sciences
Federico Piñero, Fernando Rubinstein, Sebastián Marciano, Nora Fernández, Jorge Silva, Yanina Zambelo, Margarita Anders, Alina Zerega, Ezequiel Ridruejo, Carlos Miguez, Beatriz Ameigeiras, Claudia D'Amico, Luis Gaite, Carla Bermúdez, Carlos Rosales, Gustavo Romero, Lucas McCormack, Virginia Reggiardo, Luis Colombato, Adrián Gadano, Marcelo Silva
BACKGROUND: Biannual ultrasound (US) is recommended as the clinical screening tool for hepatocellular carcinoma (HCC). The effectiveness of surveillance according to the place where US is performed has not been previously reported. AIMS: To compare the effectiveness of US performed in the center responsible for follow-up as opposed to US proceeding from centers other than that of follow-up. METHODS: This is a multicenter cohort study from Argentina...
December 3, 2018: Digestive Diseases and Sciences
Kirstine S Tølbøl, Birgit Stierstorfer, Jörg F Rippmann, Sanne S Veidal, Kristoffer T G Rigbolt, Tanja Schönberger, Matthew P Gillum, Henrik H Hansen, Niels Vrang, Jacob Jelsing, Michael Feigh, Andre Broermann
BACKGROUND: There is a marked need for improved animal models of nonalcoholic steatohepatitis (NASH) to facilitate the development of more efficacious drug therapies for the disease. METHODS: Here, we investigated the development of fibrotic NASH in male Wistar rats fed a choline-deficient L-amino acid-defined (CDAA) diet with or without cholesterol supplementation for subsequent assessment of drug treatment efficacy in NASH biopsy-confirmed rats. The metabolic profile and liver histopathology were evaluated after 4, 8, and 12 weeks of dieting...
December 3, 2018: Digestive Diseases and Sciences
Hemant Goyal, Abhilash Perisetti, M Rubayat Rahman, Avi Levin, Giuseppe Lippi
Calcitriol (1,25(OH)2 D3 ) performs various activities throughout the body. Although low serum 25-hydroxyvitamin D [25(OH)D] levels are associated with several disease processes such as risk of fractures and falls, hypertension, cardiovascular disease, and diabetes mellitus, recent evidence attests that this important hormone also regulates several cellular pathways involved in cancer development and progression. Calcitriol modulates several genes controlling gut physiology and calcium homeostasis and also maintains the integrity of epithelial barriers, regulates the absorption of phosphate and calcium, and modulates host defense against pathogens and inflammatory response by interplaying with several types of secretory and immune cells...
December 3, 2018: Digestive Diseases and Sciences
Bryan P Kline, Kathleen M Schieffer, Christine S Choi, Tara Connelly, Jeffrey Chen, Leonard Harris, Sue Deiling, Gregory S Yochum, Walter A Koltun
BACKGROUND: The management of diverticulitis is compromised by difficulty in identifying patients who require surgery for recurrent or persistent disease. Here, we introduce the concept of multifocal diverticulitis (MFD), characterized by multiple episodes of diverticulitis occurring at different locations within the colon. AIMS: To compare clinical characteristics, success of surgical management, and colonic transcriptomes of MFD patients to patients with conventional unifocal diverticulitis (UFD)...
December 3, 2018: Digestive Diseases and Sciences
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