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Digestive Diseases and Sciences

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https://www.readbyqxmd.com/read/29450749/an-analysis-of-the-clinical-laboratory-and-histological-features-of-striped-punctate-and-nodular-gastric-antral-vascular-ectasia
#1
Arul Thomas, David Koch, William Marsteller, David Lewin, Adrian Reuben
BACKGROUND: Gastric antral vascular ectasia (GAVE) commonly presents as linear striped ("watermelon stomach") or punctate phenotypes, to which a newly discovered nodular form was recently added. AIMS: We performed a retrospective cohort study to detail and compare the clinical and histological characteristics of major GAVE phenotypes. METHODS: In 136 GAVE patients (tertiary care ambulatory and inpatient, median age 61.3 years, 73 men, and 63 women), clinical and laboratory results were recorded, with comorbidities, endoscopy indications, and complications of cirrhosis...
February 15, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29450748/water-exchange-versus-split-dose-bowel-preparation-and-the-adr-is-we-there-yet
#2
EDITORIAL
Felix W Leung, Hui Jia
No abstract text is available yet for this article.
February 15, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29450747/efficacy-of-bifidobacterium-breve-fermented-milk-in-maintaining-remission-of-ulcerative-colitis
#3
Katsuyoshi Matsuoka, Yukari Uemura, Takanori Kanai, Reiko Kunisaki, Yasuo Suzuki, Kaoru Yokoyama, Naoki Yoshimura, Toshifumi Hibi
BACKGROUND: Fermented milk products containing Bifidobacterium breve strain Yakult (BFM) may improve clinical status in ulcerative colitis (UC) patients. AIMS: To assess efficacy of BFM in maintaining remission in Japanese patients with quiescent UC. METHODS: This double-blind study (B-FLORA) enrolled 195 patients with quiescent UC, randomized to receive one pack of BFM fermented milk per day [Bifidobacterium breve strain Yakult (10 billion bacteria) and Lactobacillus acidophilus (1 billion bacteria)] (n = 98) or matching placebo (n = 97) for 48 weeks...
February 15, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29442276/novel-albumin-bilirubin-grade-based-risk-prediction-model-for-patients-with-hepatocellular-carcinoma-undergoing-chemoembolization
#4
Jung Hee Kim, Dong Hyun Sinn, Jeong-Hoon Lee, Dongho Hyun, Sung Ki Cho, Sung Wook Shin, Young Chang, Yoon Jun Kim, Jung-Hwan Yoon, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Moon Seok Choi
BACKGROUND: Recently, albumin-bilirubin (ALBI) grade has been suggested as a better surrogate for hepatic functional reserve for patients with hepatocellular carcinoma (HCC). AIMS: We developed and validated a novel prediction model to predict outcome for HCC patients who underwent transcatheter arterial chemoembolization (TACE) as a first-line therapy. METHODS: From a multivariate Cox regression model for overall survival, five objective variables (ALBI grade), the Barcelona clinic liver cancer (BCLC) stage, response after the first TACE session, Alpha-fetoprotein level, and sex were chosen and the ABRAS score was developed from the derivation cohort (n = 476) and scored to generate an 8-point risk prediction model...
February 13, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29442275/five-novel-oncogenic-signatures-could-be-utilized-as-afp-related-diagnostic-biomarkers-for-hepatocellular-carcinoma-based-on-next-generation-sequencing
#5
Zheng Yu, Rongchang Wang, Fan Chen, Jianru Wang, Xiaohui Huang
BACKGROUND: Alpha-fetal protein (AFP) is an important conventional clinical diagnostic indicator of hepatocellular carcinoma (HCC). However, the utilization of AFP alone might yield deceptive results due to its limited sensitivity and accuracy. AIMS: Our study was designed to investigate latent diagnostic biomarkers that could function as auxiliary clinical indicators of HCC and enhance the accuracy of joint diagnosis with AFP. METHODS: We analyzed gene expression profiles and clinical data from HCC patients in The Cancer Genome Atlas database...
February 13, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29435701/acknowledgment-of-2017-reviewers
#6
(no author information available yet)
No abstract text is available yet for this article.
February 12, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29427225/autophagy-strengthens-intestinal-mucosal-barrier-by-attenuating-oxidative-stress-in-severe-acute-pancreatitis
#7
Luqiao Huang, Yingjian Jiang, Zhenqing Sun, Zhengyu Gao, Jiang Wang, Dianliang Zhang
BACKGROUND: Intestinal mucosal barrier dysfunction can be caused by severe acute pancreatitis (SAP). It is normally associated with changes to mucosal autophagy and oxidative stress. OBJECTIVE: The aim of this study was to investigate the correlation between autophagy and oxidative stress on the intestinal mucosal barrier of SAP rat model. METHODS: SAP was induced by retrograde injection of sodium taurocholate (5%) into the biliopancreatic duct...
February 9, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29427224/chemoprevention-by-probiotics-during-1-2-dimethylhydrazine-induced-colon-carcinogenesis-in-rats
#8
Sohini Walia, Rozy Kamal, D K Dhawan, S S Kanwar
BACKGROUND: Probiotics are believed to have properties that lower the risk of colon cancer. However, the mechanisms by which they exert their beneficial effects are relatively unknown. AIM: To assess the impact of probiotics in preventing induction of colon carcinogenesis in rats. METHODS: The rats were divided into six groups viz., normal control, Lactobacillus plantarum (AdF10)-treated, Lactobacillus rhamnosus GG (LGG)-treated, 1,2-dimethylhydrazine (DMH)-treated, L...
February 9, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29427223/gastric-acid-and-enteric-infections-souring-on-the-use-of-ppis
#9
EDITORIAL
Herbert L DuPont
No abstract text is available yet for this article.
February 9, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29427222/long-noncoding-rna-gaplinc-promotes-cells-migration-and-invasion-in-colorectal-cancer-cell-by-regulating-mir-34a-c-met-signal-pathway
#10
Yuqi Luo, Jun Ouyang, Donggen Zhou, Shizhen Zhong, Minjie Wen, Wentao Ou, Haitao Yu, Lin Jia, Yaoxin Huang
BACKGROUND: Gastric adenocarcinoma predictive long intergenic noncoding RNA (GAPLINC) has been detected in colorectal cancer (CRC) cells and reportedly performs many functions related to tumor proliferation and metastasis. Aim The present study aimed to comprehensively explore the biological functions of GAPLINC and their underlying mechanism in CRC cell. METHODS: The human cancer LncRNA PCR array was used to detect the differentially expressed long noncoding RNAs in human CRC samples...
February 9, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29417332/left-sided-colectomy-one-of-the-important-risk-factors-of-metachronous-colorectal-adenoma-after-colectomy-for-colon-cancer
#11
Gee Young Yun, Hee Seok Moon, In Sun Kwon, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
BACKGROUND: Patients with a history of colonic resection for cancer have an increased risk for the development of metachronous malignant lesions. However, there is a lack of data on the detection rates of premalignant lesions during colonoscopy surveillance in these patients, and the few existing studies have shown conflicting results. AIMS: To identify the risk factor of metachronous premalignant lesions after colon cancer surgery. METHODS: We retrospectively screened consecutive patients who had undergone colonic surgery to treat colon cancer at the Chungnam National University Hospital between September 2009 and April 2014...
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29417331/risk-factors-for-clostridium-difficile-isolation-in-inflammatory-bowel-disease-a-prospective-study
#12
Dejan Micic, Andres Yarur, Alex Gonsalves, Vijaya L Rao, Susan Broadaway, Russell Cohen, Sushila Dalal, John N Gaetano, Laura R Glick, Ayal Hirsch, Joel Pekow, Atsushi Sakuraba, Seth T Walk, David T Rubin
INTRODUCTION: Clostridium difficile is the most commonly isolated stool pathogen in inflammatory bowel disease (IBD). Traditional risk factors for C. difficile may not exist in patients with IBD, and no prior studies have assessed the risk factors for the isolation of C. difficile in both symptomatic and asymptomatic IBD outpatients. METHODS: We prospectively recruited consecutive IBD patients presenting to our outpatient clinic between April 2015 and February 2016...
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29417330/igg4-related-disease-mimicking-crohn-s-disease-a-case-report-and-review-of-literature
#13
Fabiana Ciccone, Antonio Ciccone, Mirko Di Ruscio, Filippo Vernia, Gianluca Cipolloni, Gino Coletti, Giuseppe Calvisi, Giuseppe Frieri, Giovanni Latella
No abstract text is available yet for this article.
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29417329/concise-commentary-presurgical-evaluation-of-ipmns-eight-is-enough
#14
EDITORIAL
Nicholas J Zyromski
No abstract text is available yet for this article.
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29417328/identification-of-small-proteins-and-peptides-in-the-differentiation-of-patients-with-intraductal-mucinous-neoplasms-of-the-pancreas-chronic-pancreatitis-and-pancreatic-adenocarcinoma
#15
Chiara Fania, Raffaele Pezzilli, Gianvico Melzi d'Eril, Cecilia Gelfi, Alessandra Barassi
BACKGROUND: There are a limited number of studies investigating the type of serum proteins capable of differentiating intraductal papillary mucinous neoplasms from benign or malignant diseases of the pancreas. AIMS: To select proteins able to differentiate intraductal papillary mucinous neoplasms from benign and malignant pancreatic disease using semiquantitative proteomics. METHODS: Serum samples were obtained from 74 patients (19 with type II intraductal papillary mucinous neoplasms, 8 with type I/III intraductal papillary mucinous neoplasms, 24 with chronic pancreatitis, 23 with pancreatic ductal adenocarcinomas) and 21 healthy subjects...
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29417327/infliximab-versus-adalimumab-in-patients-with-biologic-na%C3%A3-ve-crohn-s-disease-is-the-difference-real
#16
EDITORIAL
Tamara Mogilevski, Miles P Sparrow
No abstract text is available yet for this article.
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29417326/role-of-esophageal-metal-stents-placement-and-combination-therapy-in-inoperable-esophageal-carcinoma-a-systematic-review-and-meta-analysis
#17
Andrew Lai, Seth Lipka, Ambuj Kumar, Sajiv Sethi, David Bromberg, Nanxing Li, Huafeng Shen, Lilia Stefaniwsky, Patrick Brady
INTRODUCTION: More than 50% of patients with esophageal cancer already have inoperable disease at the time of diagnosis. Controversy surrounds the outcomes of patients with advanced esophageal cancer who receive palliative care by either stent alone or stent plus an additional modality. We set out to perform a systematic review and meta-analysis of studies assessing the use of metal stents as treatment options for symptomatic improvement, survival, and adverse events. METHODS: We searched Embase, MEDLINE, and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception until January 14, 2016, as well as other databases for randomized controlled trials (RCTs) comparing esophageal stent versus either esophageal stent plus brachytherapy, radiotherapy, or chemotherapy...
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29417325/preoperative-right-sided-cardiac-congestion-is-associated-with-gastrointestinal-bleeding-in-patients-with-continuous-flow-left-ventricular-assist-devices
#18
Yutaka Tomizawa, Akiko Tanaka, Hiroto Kitahara, Atsushi Sakuraba, Nir Uriel, Valluvan Jeevanandam, Takeyoshi Ota
BACKGROUND: Large scale data on preoperative risk stratification for gastrointestinal bleeding (GIB) following continuous-flow left ventricular assist device (CF-LVAD) implantation are scarce. AIMS: To identify independent predictors for GIB following CF-LVAD implantation. METHODS: We conducted a retrospective cohort study of consecutive 243 patients who underwent CF-LVAD implantation (HeartMateII) from January 2009 to March 2015 at the University of Chicago Medical Center...
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29411209/crohn-s-disease-in-niemann-pick-disease-type-c1-caught-in-the-cross-fire-of-host-microbial-interactions
#19
EDITORIAL
Athena Cavounidis, Holm H Uhlig
No abstract text is available yet for this article.
February 6, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29411208/stool-pcr-for-gastrointestinal-pathogens-in-patients-with-and-without-immune-mediated-intestinal-diseases
#20
Yael R Nobel, Jordan Axelrad, Suzanne K Lewis, Susan Whittier, Garrett Lawlor, Simon Lichtiger, Peter H R Green, Benjamin Lebwohl
BACKGROUND: Patients with celiac disease and inflammatory bowel disease, two immune-mediated luminal conditions, have higher rates of certain infections than healthy counterparts. The prevalence of many gastrointestinal infections in these patients, however, is unknown. AIMS: Using a novel clinical stool pathogen PCR test, we investigated the hypothesis that patients with celiac disease/inflammatory bowel disease had different distributions of diarrheal pathogens than other patients...
February 6, 2018: Digestive Diseases and Sciences
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