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Digestive Diseases and Sciences

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https://www.readbyqxmd.com/read/29691780/combinatory-rna-sequencing-analyses-reveal-a-dual-mode-of-gene-regulation-by-adar1-in-gastric-cancer
#1
Charles J Cho, Jaeeun Jung, Lushang Jiang, Eun Ji Lee, Dae-Soo Kim, Byung Sik Kim, Hee Sung Kim, Hwoon-Yong Jung, Ho-June Song, Sung Wook Hwang, Yangsoon Park, Min Kyo Jung, Chan Gi Pack, Seung-Jae Myung, Suhwan Chang
BACKGROUND: Adenosine deaminase acting on RNA 1 (ADAR1) is known to mediate deamination of adenosine-to-inosine through binding to double-stranded RNA, the phenomenon known as RNA editing. Currently, the function of ADAR1 in gastric cancer is unclear. AIMS: This study was aimed at investigating RNA editing-dependent and editing-independent functions of ADAR1 in gastric cancer, especially focusing on its influence on editing of 3' untranslated regions (UTRs) and subsequent changes in expression of messenger RNAs (mRNAs) as well as microRNAs (miRNAs)...
April 25, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29691779/nomogram-and-validity-of-a-model-for-predicting-malnutrition-in-patients-on-liver-transplant-lists
#2
María Teresa García-Rodríguez, Sonia Pértega-Díaz, Beatriz López-Calviño, María Del Carmen Piñón-Villar, Alejandra Otero-Ferreiro, Francisco Suárez-López, Manuel Gómez-Gutiérrez, María Teresa Seoane-Pillado, Salvador Pita-Fernández
BACKGROUND: Malnutrition is associated with increased morbimortality in liver transplant patients, and it is important to identify factors related to nutritional status in these patients. AIMS: Determine variables associated with malnutrition and create a nomogram in liver transplant candidates. METHODS: Cross-sectional study (n = 110). VARIABLES: demographic variables, imbalances due to the disease, transplant aetiology and analytical parameters...
April 25, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29679298/future-of-treatment-for-nonalcoholic-steatohepatitis-can-the-use-of-safe-evidence-based-clinically-proven-supplements-provide-the-answer-to-the-unmet-need
#3
REVIEW
Yaron Ilan
The epidemic of nonalcoholic fatty liver disease (NAFLD) has created a real and unmet therapeutic need. The long regulatory pathway and the focus on selected subsets of patients with established and advanced disease are some of the current obstacles to providing effective treatment for the majority of NAFLD patients. The complexity of the disease pathogenesis, which involves multiple mechanisms, requires targeting of more than one pathway or a combination-based therapy. Although the drugs being developed may prevent progression to cirrhosis or may decrease negative liver outcomes, their effects on cardiometabolic health and cancer prevention remain unknown...
April 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29679297/animal-models-of-diverticulosis-review-and-recommendations
#4
REVIEW
Bhavesh Patel, Xiaomei Guo, Jillian Noblet, Sean Chambers, Ghassan S Kassab
Diverticulosis is a structural alteration of the colon tissue characterized by the development of pouch-like structures called diverticula. It afflicts a significant portion of the population in Western countries, with a higher prevalence among the elderly. Diverticulosis is believed to be the result of a synergetic interaction between inherent tissue weakness, diet, colonic microstructure, motility, and genetic factors. A validated etiology has, however, not yet been established. Non-surgical treatment is currently lacking due to this poor understanding, and surgical colon resection is the only long-term solution following recurrent complications...
April 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29675665/thyroid-dysfunction-and-nonalcoholic-fatty-liver-disease-we-need-new-larger-and-well-designed-longitudinal-studies
#5
LETTER
Alessandro Mantovani, Giorgio Grani
No abstract text is available yet for this article.
April 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29675664/how-should-we-report-endoscopic-results-in-patient-s-with-barrett-s-esophagus
#6
REVIEW
Venkata Subhash Gorrepati, Prateek Sharma
Barrett's esophagus is the only known pre-cancerous lesion for esophageal adenocarcinoma and is diagnosed by high-definition white light endoscopy demonstrating a columnar-lined esophagus along with biopsy evidence of intestinal metaplasia. With accurate performance and reporting of the endoscopic procedure, an evidence-based management strategy can be developed for treatment of Barrett's dysplasia. However, cross-sectional data demonstrate that there is still inconsistency among gastroenterologists in performance and reporting of endoscopic findings in patients with Barrett's esophagus...
April 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29675663/origins-of-metaplasia-in-barrett-s-esophagus-is-this-an-esophageal-stem-or-progenitor-cell-disease
#7
REVIEW
Wei Zhang, David H Wang
The incidence of esophageal adenocarcinoma has been increasing in Western countries over the past several decades. Though Barrett's esophagus, in which the normal esophageal squamous epithelium is replaced with metaplastic intestinalized columnar cells due to chronic damage from gastroesophageal reflux, is accepted as the requisite precursor lesion for esophageal adenocarcinoma, the Barrett's esophagus cell of origin and the molecular mechanism underlying esophageal epithelial metaplasia remain controversial...
April 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29675662/portal-hypertensive-bleeding-a-navel-approach
#8
Sarah Safadi, Adam Nicol Delu, Joseph Alcorn, Denis McCarthy
No abstract text is available yet for this article.
April 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29675661/topical-steroids-and-elimination-diets-for-eoe-happier-together
#9
EDITORIAL
Carla M Davis
No abstract text is available yet for this article.
April 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29675660/rates-of-prevalent-colorectal-cancer-occurrence-in-persons-75-years-of-age-and-older-a-population-based-national-study
#10
Vijit Chouhan, Emad Mansoor, Sravanthi Parasa, Gregory S Cooper
BACKGROUND/AIMS: There is a lack of studies describing the epidemiology of colorectal cancer (CRC) in patients aged 75 years and older (elderly). Current guidelines recommend against routine screening colonoscopies in this population. We sought to describe the epidemiology of CRC in the elderly, utilizing a large, population-based database as this may impact screening guidelines in this population. METHODS: Utilizing a commercial database (Explorys Inc, Cleveland, OH), we identified a cohort of patients with a first-ever diagnosis of CRC between 2012 and 2017 based on the Systematized Nomenclature of Medicine-Clinical Terms...
April 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29671162/gi-bleeding-risk-of-doacs-versus-warfarin-is-newer-better
#11
EDITORIAL
Linda A Feagins, Rick A Weideman
No abstract text is available yet for this article.
April 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29671161/under-evaluated-or-unassessed-pathogenic-pathways-in-autoimmune-hepatitis-and-implications-for-future-management
#12
REVIEW
Albert J Czaja
Autoimmune hepatitis is a consequence of perturbations in homeostatic mechanisms that maintain self-tolerance but are incompletely understood. The goals of this review are to describe key pathogenic pathways that have been under-evaluated or unassessed in autoimmune hepatitis, describe insights that may shape future therapies, and encourage investigational efforts. The T cell immunoglobulin mucin proteins constitute a family that modulates immune tolerance by limiting the survival of immune effector cells, clearing apoptotic bodies, and expanding the population of granulocytic myeloid-derived suppressor cells...
April 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29671160/cardiac-metaplasia-follow-treat-or-ignore
#13
REVIEW
Stuart J Spechler
Over the past two decades, evidence has accumulated to challenge the traditional view that cardiac mucosa, which is comprised exclusively of mucus glands, is the normal lining of the most proximal portion of the stomach (the gastric cardia). There is now considerable evidence to suggest that cardiac mucosa develops as a GERD-induced, squamous-to-columnar esophageal metaplasia in some, if not all, cases. Although cardiac mucosa lacks the goblet cells commonly required for a histologic diagnosis of intestinal metaplasia, cardiac mucosa has many molecular features of an intestinal-type mucosa, and appears to be the precursor of intestinal metaplasia with goblet cells...
April 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29671159/clinical-guidelines-update-on-the-diagnosis-and-management-of-barrett-s-esophagus
#14
REVIEW
Michelle Clermont, Gary W Falk
Barrett's esophagus is a condition in which metaplastic columnar epithelium replaces stratified squamous epithelium in the distal esophagus. This condition occurs due to chronic gastroesophageal reflux disease and is a risk factor for the development of esophageal adenocarcinoma. Multiple clinical guidelines have been published around the world in recent years to assist gastroenterologists in the management of these patients and have evolved as new data have become available. While some information such as surveillance technique has not drastically changed, there has been an evolution over the years in diagnostic criteria, screening and endoscopic therapy with a variety of subtle differences among the different guidelines...
April 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29671158/barrett-s-esophagus-and-esophageal-adenocarcinoma-how-common-are-they-really
#15
REVIEW
Aaron P Thrift
Since the early 1970s, the incidence of esophageal adenocarcinoma (EA) has increased dramatically in most Western populations while the incidence of esophageal squamous cell carcinoma has decreased. As a result, EA has become the predominant subtype of esophageal cancer in North America and Europe and is an important contributor to overall cancer mortality. Barrett's esophagus (BE), a metaplastic columnar epithelium of the distal esophagus, is the known precursor lesion for EA. EA and BE occur more frequently in white men over 50 years old, as well as in people with frequent symptoms of gastroesophageal reflux, in smokers, and in people who are obese...
April 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29671157/natural-history-of-the-post-ablation-esophagus
#16
REVIEW
Craig C Reed, Nicholas J Shaheen
Endoscopic ablative therapy including radiofrequency ablation (RFA) represents the preferred management strategy for dysplastic Barrett's esophagus (BE) and appears to diminish the risk of developing esophageal adenocarcinoma (EAC). Limited data describe the natural history of the post-ablation esophagus. Recent findings demonstrate that recurrent intestinal metaplasia (IM) following RFA is relatively frequent. However, dysplastic BE and EAC subsequent to the complete eradication of intestinal metaplasia (CEIM) are uncommon...
April 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29663266/hepatitis-b-virus-screening-and-reactivation-in-a-national-va-cohort-of-patients-with-inflammatory-bowel-disease-treated-with-tumor-necrosis-factor-antagonists
#17
Rajesh Shah, Edith Y Ho, Jennifer R Kramer, Peter Richardson, Shubhada Sansgiry, Hashem B El-Serag, Jason K Hou
BACKGROUND: Practice guidelines recommend screening for hepatitis B virus (HBV) infection prior to initiating treatment of inflammatory bowel disease (IBD) with anti-tumor necrosis factor (anti-TNF) therapy. However, the adherence to these screening guidelines and the clinical outcomes of HBV reactivation following anti-TNF use are not well known. METHODS: This is a retrospective cohort study using the Veterans Health Administration datasets for IBD patients with filled prescriptions for anti-TNFs from 2003 to 2011...
April 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29663265/telemedicine-and-mobile-health-technology-are-effective-in-the-management-of-digestive-diseases-a-systematic-review
#18
REVIEW
Brian C Helsel, Joel E Williams, Kristen Lawson, Jessica Liang, Jonathan Markowitz
BACKGROUND: Mobile applications and interactive websites are an increasingly used method of telemedicine, but their use lacks evidence in digestive diseases. AIM: This study aims to explore digestive disease studies that use telemedicine to effectively manage disease activity, help monitor symptoms, improve compliance to the treatment protocol, increase patient satisfaction, and enhance the patient-to-provider communication. METHODS: EBSCO, PubMed, and Web of Science databases were searched using Medical Subject Headings and other keywords to identify studies that utilized telemedicine in patients with digestive disease...
April 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29663264/no-association-of-timing-of-endoscopic-biliary-drainage-with-clinical-outcomes-in-patients-with-non-severe-acute-cholangitis
#19
Ryunosuke Hakuta, Tsuyoshi Hamada, Yousuke Nakai, Hirofumi Kogure, Rie Uchino, Naminatsu Takahara, Suguru Mizuno, Tatsunori Suzuki, Tatsuya Sato, Tsuyoshi Takeda, Kazunaga Ishigaki, Kei Saito, Tomotaka Saito, Minoru Tada, Hiroyuki Isayama, Kazuhiko Koike
BACKGROUND: Biliary drainage via endoscopic retrograde cholangiopancreatography (ERCP) is the first-line treatment for acute cholangitis. Despite the established effectiveness of urgent biliary drainage in patients with severe acute cholangitis, the indication of this procedure for non-severe acute cholangitis is controversial. AIMS: To assess the safety of elective drainage (≥ 12 h of admission) for non-severe acute cholangitis. METHODS: We retrospectively identified 461 patients with non-severe acute cholangitis who underwent endoscopic biliary drainage...
April 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29663263/concise-commentary-visceral-obesity-sarcopenia-and-cancer-surgery-increasing-fitness-decreases-risk
#20
EDITORIAL
Oliver A Varban
No abstract text is available yet for this article.
April 16, 2018: Digestive Diseases and Sciences
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