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Digestive Diseases and Sciences

Amine Benmassaoud, Talal Al-Taweel, Mark Solomon Sasson, Dasha Moza, Matthew Strohl, Uri Kopylov, Laurence Paradis-Surprenant, Mohanad Almaimani, Alain Bitton, Waqqas Afif, Peter L Lakatos, Talat Bessissow
BACKGROUND: Direct head-to-head studies comparing the long-term outcomes of infliximab (IFX) to adalimumab (ADA) in Crohn's disease (CD) are sparse. AIMS: We compared the short-term and long-term efficacy and safety of IFX and ADA in CD. METHODS: We performed a single-center retrospective study including biologic-naïve adult patients with CD who were started on IFX or ADA at the McGill University Health Center. The primary end points were clinical response and remission at 12 months...
December 14, 2017: Digestive Diseases and Sciences
Loren G Rabinowitz, Haley M Zylberberg, Alan Levinovitz, Melissa S Stockwell, Peter H R Green, Benjamin Lebwohl
BACKGROUND: There has been a marked increase in the adoption of the gluten-free (GF) diet. AIMS: To query individuals with celiac disease (CD) and non-celiac gluten sensitivity (NCGS) on their beliefs toward the health effects of gluten, and safety of vaccines and GF food products. METHODS: We distributed a Web-based survey to individuals with CD and NCGS on a CD center e-mail list. We used univariate and multivariate analysis to compare responses of respondents with CD and NCGS...
December 14, 2017: Digestive Diseases and Sciences
Patrick G Brady, Pushpak Taunk
No abstract text is available yet for this article.
December 14, 2017: Digestive Diseases and Sciences
Li Wang, Brandon S Sprung, Arthur J DeCross, Danielle Marino
BACKGROUND AND AIMS: Split-dose bowel preparation is associated with improved mucosal visualization and patient tolerance, becoming a standard of care. However, quality measures data associated with this preparation are limited. At our academic tertiary-care facility, we aim to study the effect of changing from single- to split-dose preparation on colonoscopy quality measures. METHODS: A retrospective cohort study with quality indicators was conducted using electronic medical record data...
December 14, 2017: Digestive Diseases and Sciences
Wa'el Tuqan, Sarah Lee, Joshua Hanson, Denis McCarthy
No abstract text is available yet for this article.
December 14, 2017: Digestive Diseases and Sciences
Xiaoyun Zhang, Chuan Li, Tianfu Wen, Wei Peng, Lunan Yan, Jiayin Yang
BACKGROUND: The treatment of intrahepatic recurrent hepatocellular carcinoma (HCC) has been poorly investigated, and the optimal treatment strategy remains unclear. AIMS: The aim of this study was to compare outcomes between salvage liver transplantation (SLT) and re-resection (RR)/radiofrequency ablation (RFA) for intrahepatic recurrent HCC according to recurrence pattern. METHODS: Based on postoperative histopathological examination, 122 patients with intrahepatic recurrent HCC were divided into an intrahepatic metastasis (IM, n = 75) group and a multicentric occurrence (MO, n = 47) group...
December 14, 2017: Digestive Diseases and Sciences
Cameron Schlegel, Victoria G Weis, Byron C Knowles, Lynne A Lapierre, Martin G Martin, Paul Dickman, James R Goldenring, Mitchell D Shub
OBJECTIVES: Microvillus inclusion disease (MVID) is a severe form of neonatal diarrhea, caused mainly by mutations in MYO5B. Inactivating mutations in MYO5B causes depolarization of enterocytes in the small intestine, which gives rise to chronic, unremitting secretory diarrhea. While the pathology of the small intestine in MVID patients is well described, little is known about extraintestinal effects of MYO5B mutation. METHODS: We examined stomach, liver, pancreas, colon, and kidney in Navajo MVID patients, who share a single homozygous MYO5B-P660L (1979C>T p...
December 7, 2017: Digestive Diseases and Sciences
Hirofumi Kogure, Shomei Ryozawa, Iruru Maetani, Yousuke Nakai, Hiroshi Kawakami, Ichiro Yasuda, Hitoshi Mochizuki, Hirotoshi Iwano, Hiroyuki Maguchi, Mitsuhiro Kida, Kensuke Kubota, Tsuyoshi Mukai, Osamu Hasebe, Yoshinori Igarashi, Keiji Hanada, Atsushi Irisawa, Kei Ito, Takao Itoi, Hiroyuki Isayama
BACKGROUND: Both fully covered (FC) and partially covered (PC) self-expandable metal stents (SEMSs) are now commercially available for distal malignant biliary obstruction (MBO). While FCSEMS can be easily removed at the time of re-interventions, it is theoretically prone to migration. However, few comparative data between FC and PC SEMSs have been reported. AIMS: The aim of this study was to compare clinical outcomes of FCSEMS with those of PCSEMS. METHODS: This was a multicenter, prospective study of FCSEMS for unresectable distal MBO with a historical control of PCSEMS, which was previously reported as the WATCH study...
December 7, 2017: Digestive Diseases and Sciences
Lauren C Chartier, Gordon S Howarth, Ian C Lawrance, Debbie Trinder, Scott J Barker, Suzanne Mashtoub
BACKGROUND/AIMS: Ulcerative colitis is a remitting and relapsing inflammatory bowel disorder. Current treatments are limited, and if poorly controlled, colitis may progress to colorectal cancer. Previously, Emu Oil protected the intestine in experimental models of gut damage. We aimed to determine whether Emu Oil could reduce the severity of chronic colitis and prevent the onset of neoplasia in a mouse model of colitis-associated colorectal cancer. METHODS: Female C57BL/6 mice were injected (day 0) with azoxymethane, followed by ad libitum access to three dextran sulfate sodium/water cycles (7 days of dextran sulfate sodium and 14 days of water)...
December 6, 2017: Digestive Diseases and Sciences
Aisaku Osamura, Yasuo Suzuki
BACKGROUND: Crohn's disease (CD) is an intractable disease that requires long-term treatment. Tumor necrosis factor (TNF) inhibitors have strong efficacy and are widely used for CD treatment. However, a loss of response is one of the issues in long-term TNF therapy. To identify the factors affecting the efficacy of long-term CD treatment with TNF inhibitors, we conducted a retrospective study of treatment outcomes and clinical factors using clinical data over a 14-year period. METHODS: Clinical characteristics and factors for surgery, hospitalization, and TNF inhibitor treatment discontinuation were examined in 219 biologic-naïve patients who were treated with TNF inhibitors at our hospital before October 2014...
December 5, 2017: Digestive Diseases and Sciences
Brendan Campbell, Aristeo Lopez, Benny Liu, Taft Bhuket, Robert J Wong
BACKGROUND: Safety-net hospitals are enriched in ethnic minorities and provide opportunities for high-impact hepatitis B virus (HBV) screening. AIM: We aim to evaluate the impact of a pilot program integrating HBV screening into outpatient endoscopy among urban safety-net populations. METHODS: From July 2015 to May 2017, consecutive adults undergoing outpatient endoscopy were prospectively assessed for HBV screening eligibility using US Preventative Services Task Force guidelines...
December 5, 2017: Digestive Diseases and Sciences
Eugenia N Uche-Anya, Christopher D Packey, Ali S Khan, Amrita Sethi
No abstract text is available yet for this article.
December 4, 2017: Digestive Diseases and Sciences
Elisabeth Norén, Marie-Rose Mellander, Sven Almer, Jan Söderman
BACKGROUND AND AIM: Microscopic colitis (MC) has been associated with increased paracellular permeability. Therefore, we aimed to investigate potential associations between MC and several genes encoding tight junction (TJ) proteins reported to interact with each other. METHODS: The association between MC and single nucleotide polymorphisms (SNP; n = 63) within TJ genes (F11R, MAGI1, MAGI2, MAGI3, PARD3, PTEN, and TJP1) were investigated in a case-control study (n MC patients = 104 and n controls = 423)...
December 4, 2017: Digestive Diseases and Sciences
Xue Hu, Jingjing Ma, Vikash Vikash, Jiao Li, Dandan Wu, Ya Liu, Jixiang Zhang, Weiguo Dong
BACKGROUND: Thymoquinone (TQ) is the major constituent of Nigella sativa seed and has shown biological activity in various human carcinomas. However, few studies have reported its effect on esophageal carcinoma (EC). AIMS: To explore the chemosensitive effect and mechanism of TQ in augmentation of cisplatin (DDP)-induced apoptosis of EC, both in vitro and in vivo. METHODS: The viability and apoptosis of esophageal carcinoma cells were detected by the Cell Counting Kit-8 assay, flow cytometry, and Hoechst 33258 staining...
December 2, 2017: Digestive Diseases and Sciences
Minghua Lin, Yuan Chang, Fang Xie, Ying Shi, Lijun Pang, Dexi Chen
BACKGROUND: Apoptosis-stimulating protein of p53-2 (ASPP2) is a damage-inducible P53-binding protein that enhances damage-induced apoptosis. Fibrosis is a wound-healing response, and hepatic stellate cells (HSCs) are key players in liver fibrogenesis. However, little is known about the relationship between ASPP2 and hepatic fibrosis. AIMS: We investigated the effects of ASPP2 overexpression in HSCs and the role of ASPP2 in mouse liver fibrogenesis. METHODS: Human HSCs (LX-2 cells) were pre-incubated with GFP adenovirus (Ad) or ASPP2 adenovirus (AdASPP2) for 24 h and then treated with or without TGF-β1...
December 2, 2017: Digestive Diseases and Sciences
M Hovaida, E Torrazza-Perez, D McCarthy
No abstract text is available yet for this article.
December 1, 2017: Digestive Diseases and Sciences
Mohamed Hasif Jaafar, Sher Zaman Safi, Maw-Pin Tan, Sanjay Rampal, Sanjiv Mahadeva
OBJECTIVE: The role of gastritis in dyspepsia remains controversial. We aimed to examine the efficacy of rebamipide, a gastric mucosal protective agent, in both organic and functional dyspepsia. DESIGN: A systematic review and meta-analysis was performed. The following databases were searched using the keywords ("rebamipide" OR "gastroprotective agent*" OR "mucosta") AND ("dyspepsia" OR "indigestion" OR "gastrointestinal symptoms"): PubMed, Wed of Science, Embase, CINAHL, Cochrane Clinical Trials Register...
December 1, 2017: Digestive Diseases and Sciences
Ki Tae Suk, Moon Young Kim, Soung Won Jeong, Jae Young Jang, Yoon Ok Jang, Soon Koo Baik
BACKGROUND/AIMS: Hepatopulmonary syndrome (HPS) is characterized by a defect in oxygenation induced by pulmonary vascular dilatation in cirrhosis. While severe HPS is responsible for a high rate of mortality, the prevalence and pathophysiology of HPS are not fully elucidated. We evaluated the prevalence and pathophysiology of HPS in patients with cirrhosis. METHODS: A total of 142 patients with cirrhosis who underwent saline-agitated contrast echocardiography were enrolled in this prospective observational study...
December 1, 2017: Digestive Diseases and Sciences
Hongliang Liu, Junwen Hu, Hua Pan, Dilai Luo, Mingwen Huang, Wei Xu
BACKGROUND: Increasing evidence has suggested that E3 Ubiquitin Ligase CSN5 is a newly characterized oncogene involved in various types of cancer. Scavenger receptor class A member 5 (SCARA5) is an important regulator of biological processes in cancer cells. However, the roles and relationship of CSN5 and SCARA5 in hepatocellular carcinoma (HCC) remain unclear. METHODS: We used RT-PCR, Western blot, and immunohistochemistry to measure CSN5 and SCARA5 expression in HCC tissues and corresponding non-tumor tissues...
November 30, 2017: Digestive Diseases and Sciences
Jessica R Allegretti, Zain Kassam, Walter W Chan
BACKGROUND: Fecal microbiota transplantation (FMT) is safe and effective for recurrent Clostridium difficile infection (rCDI) and often involves terminal ileal (TI) stool infusion. Patients report gastrointestinal (GI) symptoms post-FMT despite rCDI resolution. Small intestinal bacterial overgrowth (SIBO) screening is not routinely performed pre-FMT. The effect of donor/recipient SIBO status on FMT outcomes and post-FMT GI symptoms is unclear. We aim to evaluate the value of pre-FMT SIBO screening on post-FMT outcomes and symptoms...
November 29, 2017: Digestive Diseases and Sciences
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