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Digestive Diseases and Sciences

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https://www.readbyqxmd.com/read/28084605/diet-to-the-rescue-cessation-of-pharmacotherapy-after-initiation-of-exclusive-enteral-nutrition-een-followed-by-strict-and-liberalized-specific-carbohydrate-diet-scd-in-crohn-s-disease
#1
Warapan Nakayuenyongsuk, Megan Christofferson, Kaylie Nguyen, Jennifer Burgis, K T Park
No abstract text is available yet for this article.
January 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28083843/microrna-19b-expression-in-human-biliary-atresia-specimens-and-its-role-in-ba-related-fibrosis
#2
Dong Zhao, Yi Luo, Yun Xia, Jian-Jun Zhang, Qiang Xia
BACKGROUND AND AIM: Biliary atresia (BA) is a pediatric liver disease with unknown underlying etiology. MicroRNAs (miRNAs) represent a family of small noncoding RNAs. Among them, miR-19b has been suggested to function in the diseased liver. We therefore decided to investigate its potential role in BA. METHODS: We used infant-derived specimens to analyze miR-19b expression in a tissue- and cell-specific fashion, predicted interaction with genes, and finally performed a functional study in vitro...
January 12, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28083842/effect-of-vonoprazan-a-potassium-competitive-acid-blocker-on-the-13-c-urea-breath-test-in-helicobacter-pylori-positive-patients
#3
Mayu Takimoto, Toshihiko Tomita, Takahisa Yamasaki, Shota Fukui, Masato Taki, Takuya Okugawa, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Eitatsu Arai, Yoshio Ohda, Tadayuki Oshima, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
BACKGROUND AND AIM: Vonoprazan (VPZ) is a new oral potassium-competitive acid blocker that has recently become available. The aim of this study was to investigate the effects of VPZ on the urease activity of H. pylori as measured by the (13)C-urea breath test ((13)C-UBT). PATIENTS AND METHODS: A total of 60 patients (26 men, 34 women; mean age 53.2 ± 13.6 years) who were diagnosed as H. pylori-positive were recruited. The patients were randomly allocated to three treatment groups: lansoprazole (LPZ) 30 mg (n = 20), VPZ 20 mg (n = 20) once daily for 3 weeks, or the control group (n = 20)...
January 12, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28078527/circulating-endothelial-progenitor-cells-in-crohn-s-disease-an-epic-in-the-making
#4
EDITORIAL
Catharine Dietrich, Shree Ram Singh
No abstract text is available yet for this article.
January 11, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28078526/effectiveness-and-safety-of-entecavir-or-tenofovir-in-a-spanish-cohort-of-chronic-hepatitis-b-patients-validation-of-the-page-b-score-to-predict-hepatocellular-carcinoma
#5
Mar Riveiro-Barciela, David Tabernero, José L Calleja, Sabela Lens, María L Manzano, Francisco Gea Rodríguez, Javier Crespo, Belén Piqueras, Juan M Pascasio, Carmen Comas, Maria L Gutierrez, Alberto Aguirre, Emilio Suárez, Javier García-Samaniego, Miguel Rivero, Doroteo Acero, Miguel Fernandez-Bermejo, Diego Moreno, Pilar Sánchez-Pobre, Beatriz de Cuenca, J J Moreno-Palomares, Rafael Esteban, Maria Buti
BACKGROUND: Long-term antiviral therapy has resulted in viral suppression and biochemical response in chronic hepatitis B, although the risk of hepatocellular carcinoma has not been abolished. The Page-B score could be useful to estimate the probability of HCC. AIMS: To analyze the effectiveness and safety of entecavir or tenofovir for more than 4 years and the usefulness of Page-B score in the real-world setting. METHODS: Analysis of Caucasian chronic hepatitis B subjects treated with entecavir or tenofovir from the prospective, multicenter database CIBERHEP...
January 11, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28070826/interaction-of-ethnicity-and-h-pylori-infection-in-the-occurrence-of-microscopic-colitis
#6
Amnon Sonnenberg, Kevin O Turner, Robert M Genta
BACKGROUND: Previous studies found that microscopic colitis is inversely associated with Helicobacter pylori infection and that microscopic colitis is characterized by a marked ethnic variation. AIM: The aim of the present study was to test whether an underlying ethnic variation of H. pylori infection is responsible for the ethnic variation of microscopic colitis. METHODS: The Miraca Life Sciences Database is a large national electronic repository of histopathologic records of patients distributed throughout the entire USA...
January 9, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28070825/prevalence-and-predictors-of-giardia-in-the-united-states
#7
Haley M Zylberberg, Peter H R Green, Kevin O Turner, Robert M Genta, Benjamin Lebwohl
BACKGROUND: Infection with Giardia lamblia is a common cause of diarrheal disease in the developing and industrialized world. AIMS: We aimed to assess the prevalence of giardiasis in the United States (US) among patients with duodenal biopsies, investigating demographic and clinical factors associated with this condition. METHODS: We conducted a cross-sectional study of patients with duodenal biopsies submitted to a national pathology laboratory between January 2, 2008, and December 31, 2015...
January 9, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28058597/when-it-rains-it-pours-evolving-complicated-small-intestinal-crohn-s-disease
#8
George Triadafilopoulos, Saul Eisenstat, Shane Dormady, Robert Sinha, Fabio Komlos, Charles Lombard
No abstract text is available yet for this article.
January 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28058596/comparative-analysis-of-mutational-profile-of-sonic-hedgehog-gene-in-gallbladder-cancer
#9
Ruhi Dixit, Manoj Pandey, Sunil Kumar Tripathi, Amit Nandan Dhar Dwivedi, Vijay Kumar Shukla
BACKGROUND: Gallbladder cancer has high incidence in northeastern India; mortality too is high as the disease is often diagnosed late. Numerous studies have shown the role of sonic hedgehog (shh) in different cancers, an important ligand of the hedgehog signaling pathway. AIM: This study was carried out to evaluate the shh gene mutations in gallbladder cancer patients. METHODS: PCR-SSCP was performed for shh gene in 50 samples each of gallbladder cancer, cholelithiasis, and control...
January 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28058595/mutation-detection-of-fibroblast-growth-factor-receptor-3-for-infiltrative-hepatocellular-carcinoma-by-whole-exome-sequencing
#10
Xiaopeng Yan, Cong Shao, Chuang Chen, Jun Chen, Shen Gu, Luoshun Huang, Xu Fu, Hui Zhao, Yudong Qiu
BACKGROUND: Gene data on infiltrative hepatocellular carcinoma (iHCC) are still unknown. AIMS: This study aims to identify the gene expression signature of iHCC compared with single nodular (SN)-type HCC according to the gross classification. METHODS: The whole-exome sequencing was performed in six matched HCC tumor/normal pairs (three infiltrative type and three single nodular type) from six patients who received curative hepatectomy. Subsequent validation using Sanger sequencing and real-time PCR was performed in 30 HCC tumor samples (15 infiltrative type and 15 single nodular type)...
January 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28058594/an-algorithm-for-management-after-transjugular-intrahepatic-portosystemic-shunt-placement-according-to-clinical-manifestations
#11
REVIEW
Seung Kwon Kim, Bryan G Belikoff, Carlos J Guevara, Seong Jin Park
We propose an algorithm for management after transjugular intrahepatic portosystemic shunt (TIPS) placement according to clinical manifestations. For patients with an initial good clinical response, surveillance Doppler ultrasound is recommended to detect stenosis or occlusion. A TIPS revision can be performed using basic or advanced techniques to treat stenosis or occlusion. In patients with an initial poor clinical response, a TIPS venogram with pressure measurements should be performed to assess shunt patency...
January 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28054162/patients-age-rather-than-model-of-end-stage-liver-disease-score-predicts-survival-after-liver-transplantation
#12
Yaara Leibovici-Weissman, Eytan Mor, Moshe Leshno, Amir Shlomai
BACKGROUND: The model of end-stage liver disease (MELD) score is the standard tool for prioritizing patients awaiting liver transplantation. There is currently no definite high cutoff score reflecting disease severity that might exclude patients from transplantation. Furthermore, the age limit that used to disqualify patients from eligibility to transplantation was recently withdrawn in several countries. AIMS: The aims of this study were to assess the effects of MELD score and age at time of transplantation on patients' short- and long-term survival...
January 4, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28050786/multicenter-prospective-study-on-the-safety-of-upper-gastrointestinal-endoscopic-procedures-in-antithrombotic-drug-users
#13
Yoshiyasu Kono, Minoru Matsubara, Tatsuya Toyokawa, Ryuta Takenaka, Seiyu Suzuki, Junichirou Nasu, Masao Yoshioka, Masahiro Nakagawa, Motowo Mizuno, Hiroyuki Sakae, Makoto Abe, Tatsuhiro Gotoda, Ko Miura, Hiromitsu Kanzaki, Masaya Iwamuro, Keisuke Hori, Takao Tsuzuki, Masahide Kita, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada
BACKGROUND: The Japan Gastroenterological Endoscopy Society updated its guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment in July 2012. However, the safety of endoscopic procedures in antithrombotic drug users has not been fully investigated. AIMS: To evaluate the safety of upper gastrointestinal endoscopic procedures in antithrombotic drug users. METHODS: From September 2013 to September 2015, patients who were taking antithrombotic drugs and who underwent upper gastrointestinal endoscopic procedures were prospectively enrolled at five hospitals...
January 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28050785/india-needs-effective-surveillance-to-control-hepatitis-c
#14
LETTER
Govindasamy Agoramoorthy
No abstract text is available yet for this article.
January 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28050784/roles-of-microrna-330-and-its-target-gene-ing4-in-the-development-of-aggressive-phenotype-in-hepatocellular-carcinoma-cells
#15
Xiao Hu, Yujie Feng, Lin Sun, Linlin Qu, Chuandong Sun
BACKGROUND: Aberrant expression of microRNAs contributes to tumor growth and progression. AIMS: This study was designed to explore the prognostic and biological significance of miR-330 in hepatocellular carcinoma (HCC). METHODS: The expression of miR-330 and its associations with tumor parameters and overall survival were analyzed in HCC patients. The biological functions of miR-330 in HCC cell growth, invasion, and tumorigenesis were investigated...
January 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28050783/daily-intake-of-high-fat-diet-with-lysophosphatidic-acid-rich-soybean-phospholipids-augments-colon-tumorigenesis-in-kyoto-apc-delta-rats
#16
Toshihiko Tsutsumi, Manami Inoue, Yoko Okamoto, Akira Ishihara, Akira Tokumura
BACKGROUND: Oral administration of lysophosphatidic acid (LPA) was shown to attenuate gastric ulceration in rats and mice but aggravate intestinal tumorigenesis in mice. AIMS: The present study examined whether dietary LPA induces or prevents development of colorectal tumor in rats. METHODS: Kyoto Apc Delta rats fed high-fat diet with or without an LPA-rich soybean phospholipid mixture (LSP, 0.1 or 1%) were treated with azoxymethane and dextran sodium sulfate to induce colorectal tumorigenesis...
January 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28050782/colorectal-cancer-in-inflammatory-bowel-diseases-a-population-based-study-in-utah
#17
N Jewel Samadder, John F Valentine, Stephen Guthery, Harminder Singh, Charles N Bernstein, Yuan Wan, Jathine Wong, Kenneth Boucher, Lisa Pappas, Kerry Rowe, Mary Bronner, Cornelia M Ulrich, Randall W Burt, Karen Curtin, Ken R Smith
BACKGROUND AND AIMS: The molecular, endoscopic, and histological features of IBD-associated CRC differ from sporadic CRC. The objective of this study was to describe the prevalence, clinical features, and prognosis of IBD-associated CRC compared to patients with sporadic CRC in a US statewide population-based cohort. METHODS: All newly diagnosed cases of CRC between 1996 and 2011 were obtained from Utah Cancer Registry. IBD was identified using a previously validated algorithm, from statewide databases of Intermountain Healthcare, University of Utah Health Sciences, and the Utah Population Database...
January 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28050781/the-role-of-ciap1-and-xiap-in-apoptosis-induced-by-tumor-necrosis-factor-alpha-in-esophageal-squamous-cell-carcinoma-cells
#18
Shoichiro Hikami, Atsushi Shiozaki, Maki Kitagawa-Juge, Daisuke Ichikawa, Toshiyuki Kosuga, Hirotaka Konishi, Shuhei Komatsu, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
BACKGROUND: The inhibitor of apoptosis protein (IAP) family are reported to play important roles in cancer cells evading apoptosis. However, the significance of their expression in human esophageal squamous cell carcinoma (ESCC) cells remains uncertain. AIMS: The present study aimed to investigate the role of the IAP family members in tumor necrosis factor-α (TNF-α)-induced apoptosis of human ESCC cells. METHODS: Five human ESCC cell lines were pretreated with TNF-α, cycloheximide (CHX, protein synthesis inhibitor), epoxomicin (proteasome inhibitor)...
January 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28050780/clinical-characteristics-comorbidities-and-hospital-outcomes-in-hospitalizations-with-cyclic-vomiting-syndrome-a-nationwide-analysis
#19
Sanjay Bhandari, Thangam Venkatesan
BACKGROUND: Data on cyclic vomiting syndrome (CVS) are limited to studies from tertiary care centers. There is a paucity of information about CVS on a national scale. AIM: To study the clinical characteristics, comorbidities, and hospital outcomes in patients hospitalized with CVS using a nationwide database. METHODS: We identified all hospitalizations associated with a primary diagnosis of CVS in 2010 and 2011 using the Nationwide Inpatient Sample with an age category of 18-55 years...
January 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28044230/long-term-outcomes-and-predictors-of-sustained-response-in-patients-with-intestinal-behcet-s-disease-treated-with-infliximab
#20
Jun Zou, Da-Nian Ji, Jian-Fei Cai, Jian-Long Guan, Zhi-Jun Bao
BACKGROUND: Intestinal Behcet's disease (BD) is a specific subtype of BD. Effective drug therapy for intestinal BD remains elusive. AIMS: To investigate long-term outcomes and identify predictors of sustained response in intestinal BD patients receiving infliximab (IFX) treatment. METHODS: The medical records were reviewed of patients received IFX from September 2012 to March 2016. The cumulative probabilities of sustained response were calculated using the Kaplan-Meier...
January 2, 2017: Digestive Diseases and Sciences
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