Jesus H Beltran-Ornelas, Diana L Silva-Velasco, Jorge Tapia-Martínez, Araceli Sánchez-López, Edgar Cano-Europa, Saúl Huerta de la Cruz, David Centurión
Chronic stress induces a group of unrecognized cardiovascular impairments, including elevated hemodynamic variables and vascular dysfunction. Moreover, hydrogen sulfide (H2S), a gasotransmitter that regulates the cardiovascular system, decreases under chronic stress. Thus, this study assessed the impact of NaHS (H2S donor) on chronic restraint stress (CRS)-induced cardiovascular changes. For that purpose, male Wistar rats were restrained for 2 h in a transparent acrylic tube over eight weeks. Then, body weight, relative adrenal gland weight, serum corticosterone, H2S-synthesizing enzymes, eNOS expression, reactive oxygen species (ROS) levels, lipid peroxidation, and reduced glutathione/oxidized glutathione (GSH2/GSSG) ratio, were determined in the thoracic aorta...
January 11, 2024: Journal of Cardiovascular Pharmacology