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Journal of Cardiovascular Pharmacology

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https://www.readbyqxmd.com/read/29300220/genomics-of-cardiovascular-measures-of-autonomic-tone
#1
Martin I Sigurdsson, Nathan H Waldron, Andrey V Bortsov, Shad B Smith, William Maixner
The autonomic nervous system exerts broad control over the involuntary functions of the human body via complex equilibrium between sympathetic and parasympathetic tone. Imbalance in this equilibrium is associated with a multitude of cardiovascular outcomes, including mortality. The cardiovascular static state of this equilibrium can be quantified via physiological parameters such as heart rate, blood pressure and by spectral analysis of heart rate variability.Here we review the current state of knowledge of the genetic background of cardiovascular measurements of autonomic tone...
January 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29300219/the-effect-of-a-non-peptide-angiotensin-ii-type-2-receptor-agonist-compound-21-on-aortic-aneurysm-growth-in-a-mouse-model-of-marfan-syndrome
#2
Peter Verbrugghe, Jelle Verhoeven, Marnick Clijsters, Dominique Vervoort, Jarne Schepens, Bart Meuris, Paul Herijgers
IntroductionAvailable evidence suggests that the renin-angiotensin-aldosterone (RAA) system is a good target for medical intervention on aortic root dilatation in Marfan syndrome (MFS). The effect of Compound 21 (C21), a non-peptide angiotensin II type 2 receptor (AT2R) agonist on aneurysm progression is was tested.MethodsMice with a mutation in fibrillin-1 (Fbn1C1039G/+) and wild-type (WT) mice were treated with vehicle, losartan, C21, enalapril or a combination. Blood pressure, aortic root diameter, and histological slides were evaluated...
January 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29256972/factors-influencing-various-aspects-of-patients-knowledge-of-oral-anticoagulation
#3
Leili Pourafkari, Aidin Baghbani-Oskouei, Mohammadreza Taban-Sadeghi, Vida Salamzadeh, Samad Ghaffari, Safa Savadi-Oskouei, Nader D Nader
OBJECTIVES: To identify and examine individual characteristics and socioeconomic factors that contribute to the knowledge of patients who receive warfarin anticoagulation. METHODS: All patients treated with warfarin for anticoagulation were enrolled during a 6-month period at a university-affiliated cardiac clinic. All relevant demographic and clinical information were collected and the Anticoagulation Knowledge Assessment (AKA) questionnaire consisting of 29 questions was administered...
December 18, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29256971/cardioprotective-mechanisms-of-exenatide-in-isoprenaline-induced-mi-novel-effects-on-myocardial-%C3%AE-estrogen-receptor-expression-and-igf-1-igf-2-system
#4
Ahmed M Darwesh, Mona F El-Azab, Noha M Abo-Gresha, Norhan M El-Sayed, Yasser M Moustafa
Myocardial infarction (MI) is one of the main causes of morbidity and mortality in diabetic patients. The antidiabetic glucagon-like polypeptide-1 receptor (GLP-IR) agonists, like exenatide, proved to confer cardioprotection; however, their exact mechanisms are not fully elucidated. Although the cardioprotective effect of á-estrogen receptor (ERá) is well established, its involvement in exenatide-induced cardioprotection has never been investigated. Moreover, modulation of insulin-like growth factor-1/2 (IGF-1/IGF-2) system by exenatide, and the consequent effect on cardiomyocyte apoptosis, is yet to be established...
December 18, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29140957/beneficial-effects-of-angiotensin-1-7-on-cd34-cells-from-heart-failure-patients
#5
Colleen T Cole-Jeffrey, Carl J Pepine, Michael J Katovich, Maria B Grant, Mohan K Raizada, Sugata Hazra
The dysfunctional nature of CD34 cells from heart failure (HF) patients makes them unsuitable for autologous stem cell therapy. In view of evidence that the vasoprotective axis of the renin-angiotensin system (RAS) improves CD34 cell functions, we hypothesized that CD34 cells from HF patients will be dysfunctional and that Angiotensin-(1-7) [Ang-(1-7)] would improve their function. Peripheral blood was collected from NYHA class II-IV HF patients (n=31) and reference subjects (n=16). CD34 cell numbers from HF patients were reduced by 47% (p<0...
November 8, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29112592/antihypertensive-therapy-and-new-on-set-of-diabetes-mellitus-the-double-edge-sword
#6
Reza Tabrizchi
No abstract text is available yet for this article.
October 31, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29112591/pharmacokinetics-and-dynamics-of-low-intermediate-and-high-dose-landiolol-and-esmolol-during-long-term-infusion-in-healthy-caucasians
#7
Günther Krumpl, Ivan Ulč, Michaela Trebs, Pavla Kadlecová, Juri Hodisch, Gabriele Maurer, Bernhard Husch
The pharmacokinetics, pharmacodynamics, safety, and tolerability of long-term administration of esmolol and landiolol, a new fast-acting cardioselective β-blocker, were compared for the first time in Caucasian subjects in a prospective clinical trial.Twelve healthy volunteers received landiolol and esmolol by continuous infusion for 24 hr in a randomized crossover study using a dose-escalation regimen. Blood concentrations of drugs and metabolites, heart rate, blood pressure, ECG parameters and tolerability were observed for 30 hrs and compared...
October 31, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29112590/effect-of-andrographolide-on-gene-expression-profile-and-intracellular-calcium-in-primary-rat-myocardium-microvascular-endothelial-cells
#8
Bo Feng, Qian Zhang, Xin Wang, Xiangwan Sun, Xiang Mu, Hong Dong
Andrographolide (ANDRO) is a diterpene lactone compound with extensive biological effects, such as antibacterial, antitumor and treatment of cardiovascular diseases. Until now, studies on the pharmacological functions of ANDRO are still in progress. However, little is known about the gene expression profile and calcium response of endothelial cells to ANDRO. In this study, we used a microarray technology to investigate the gene expression responses in primary rat myocardium microvascular endothelial cells (RMMECs) treated with 10μg/mL ANDRO...
October 31, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29112589/androgens-mediate-%C3%AE-adrenergic-vasorelaxation-impairment-via-adenylyl-cyclase
#9
O A López-Canales, M C Castillo-Hernández, H Vargas-Robles, A Rios, J S López-Canales, B Escalante
Cardiovascular disease development has been associated with gender differences, suggesting that sex hormones are implicated in vascular function and development of hypertension. Vascular tone comparison at different stages of rat growth represents a good model to study testosterone-related vascular response. We explored the role of testosterone in modulation of age-dependent impaired β-adrenergic vasodilation.The 3 week-old male Sprague-Dawley rats were sorted in 3 week-old rats without any manipulation and 3 week-old rats treated with testosterone...
October 31, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29076887/the-use-of-levosimendan-in-cardiac-surgery-an-update-after-the-levo-cts-cheetah-and-licorn-trials-in-the-light-of-clinical-practice
#10
Fabio Guarracino, Matthias Heringlake, Bernard Cholley, Dominique Bettex, Stefaan Bouchez, Vladimir V Lomivorotov, Angela Rajek, Matti Kivikko, Piero Pollesello
Levosimendan is a calcium sensitizer and ATP-dependent potassium channel opener which exerts sustained hemodynamic, symptomatic and organ-protective effects. It is registered for the treatment of acute heart failure, and when inotropic support is considered appropriate. In the past fifteen years, levosimendan has been widely used in clinical practice, and has also been tested in clinical trials to stabilize at-risk patients undergoing cardiac surgery. Recently, three randomized, placebo-controlled, multicenter studies (LICORN, CHEETAH and LEVO-CTS) have been published reporting on the peri-operative use of levosimendan in patients with compromised cardiac ventricular function...
October 30, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29095793/low-dose-sinapic-acid-abates-the-pyroptosis-of-macrophages-via-downregulation-of-lncrna-malat1-in-rats-with-diabetic-atherosclerosis
#11
Yong Han, Hong Qiu, Xing Pei, Yigang Fan, Hongyan Tian, Jie Geng
Pyroptosis is a type of programmed cell death, which has been associated with multiple inflammatory diseases including diabetic atherosclerosis (DA). The study aims to explore the role of sinapic acid (SA) in the pyroptosis of macrophages in diabetic atherosclerosis. Our results from the in vivo experiments showed that low-dose (≤ 50 mg/Kg) chronic SA adiministration suppressed serum endothelin 1 (ET-1) and interleukine-1β (IL-1β) contents, pyroptotic death of bone marrow derived macrophages (BMDMs), and the expression of pyroptotic proteins ASC, NRLP3 and Caspase-1...
October 27, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29095792/important-role-of-endothelial-caveolin-1-in-the-protective-role-of-edh-against-no-mediated-nitrative-stress-in-microcirculation-in-mice
#12
Hiroki Saito, Shigeo Godo, Saori Sato, Akiyo Ito, Yosuke Ikumi, Shuhei Tanaka, Tomoaki Ida, Shigemoto Fujii, Takaaki Akaike, Hiroaki Shimokawa
AIMS: Nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) play important roles in maintaining cardiovascular homeostasis. We have previously demonstrated that endothelial NO synthase (eNOS) plays diverse roles depending on vessel size, as a NO generating system in conduit arteries and an EDH-mediated system in resistance arteries, for which caveolin-1(Cav-1) is involved. However, the physiological role of endothelial Cav-1 in microvessels remains to be elucidated. METHODS AND RESULTS: We newly generated endothelium-specific Cav-1-knockout (eCav-1-KO) mice...
October 27, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29286954/selective-%C3%A3-1-blockers-are-not-associated-with-new-onset-diabetes-mellitus-in-hypertensive-patients
#13
Yoonjee Park, Byoung Geol Choi, Seung-Woon Rha, Man Jong Baek, Yang Gi Ryu, Se Yeon Choi, Jae Kyeong Byun, Min Suk Shim, Ahmed Mashaly, Hu Li, Won Young Jang, Woohyeun Kim, Jun Hyuk Kang, Jah Yeon Choi, Eun Jin Park, Sung Hun Park, Sunki Lee, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
BACKGROUND: Although ß-blockers are known to increase new-onset diabetes mellitus (DM), previous evidence have been controversial. It has been suggested that newer vasodilatory ß-blockers yield better glycemic control than older nonselective agents. The aim of this study was to evaluate the diabetogenicity of currently used newer ß-blockers based on ß1 receptor selectivity in a series of Asian population. METHODS: We investigated a total of 65,686 hypertensive patients without DM from 2004 to 2014...
January 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29283926/interactions-of-propofol-with-human-voltage-gated-kv1-5-channel-determined-by-docking-simulation-and-mutagenesis-analyses
#14
Akiko Kojima, Yutaka Fukushima, Yuki Ito, Wei-Guang Ding, Rika Ueda, Tomoyoshi Seto, Hirotoshi Kitagawa, Hiroshi Matsuura
Propofol blocks the voltage-gated human Kv1.5 (hKv1.5) channel by preferentially affecting in its open state. A previous mutational study suggested that several amino acids within the pore region of the hKv1.5 channel are involved in mediating the blocking action of propofol. The present investigation was undertaken to elucidate the predicted binding modes of propofol within the pore cavity of the open-state hKv1.5 channel, using computational docking and mutagenesis approaches. The docking simulation using a homology model of the hKv1...
January 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29216016/why-the-cantos-is-a-game-changer-in-cardiovascular-medicine
#15
Antonio Abbate
No abstract text is available yet for this article.
December 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29215436/phosphoinositide-3-kinases-and-diabetic-cardiomyopathy
#16
Richard Z Lin
No abstract text is available yet for this article.
December 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29112047/memantine-an-nmda-receptor-antagonist-prevents-thyroxin-induced-hypertension-but-not-cardiac-remodeling
#17
Steven J Repas, Nancy S Saad, Paul M L Janssen, Mohammad T Elnakish
Stimulation of glutamatergic tone has been causally linked to myocardial pathogenesis and amplified systemic blood pressure (BP). Memantine, a noncompetitive N-methyl-D-aspartate glutamatergic receptor (NMDA-R) antagonist, has been proposed to be an active cardioprotective drug. However, the efficacy of memantine and subsequently the possible involvement of the NMDA-R in the thyroxin (T4)-induced cardiovascular complications have never been investigated. We examined the effect of memantine (30 mg·kg·d) on the T4 (500 μg·kg·d)-provoked increase in mouse BP, cardiac hypertrophy indicated by enlarged overall myocardial mass, and reformed reactions of the contractile myocardium both in vivo and ex vivo after 2 weeks of treatment...
November 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28777252/n-methyl-d-aspartate-receptor-driven-calcium-influx-potentiates-the-adverse-effects-of-myocardial-ischemia-reperfusion-injury-ex-vivo
#18
Zi-You Liu, Shou Hu, Qin-Wen Zhong, Cheng-Nan Tian, Hou-Mou Ma, Jun-Jian Yu
BACKGROUND: Despite the adverse effects of N-methyl-D-aspartate receptor (NMDAR) activity in cardiomyocytes, no study has yet examined the effects of NMDAR activity under ex vivo ischemic-reperfusion (I/R) conditions. Therefore, our aim was to comprehensively evaluate the effects of NMDAR activity through an ex vivo myocardial I/R rat model. METHODS: Isolated rat hearts were randomly segregated into 6 groups (n = 20 in each group): (1) an untreated control group; (2) a NMDA-treated control group; (3) an untreated I/R group; (4) an I/R+NMDA group treated with NMDA; (5) an I/R+NMDA+MK-801 group treated with NMDA and the NMDAR inhibitor MK-801; and (6) an I/R+NMDA+[Ca]-free group treated with NMDA and [Ca]-free buffer...
November 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29068807/antiarrhythmic-effects-of-combining-dofetilide-and-ranolazine-in-a-model-of-acutely-induced-atrial-fibrillation-in-horses
#19
Helena Carstensen, Line Kjær, Maria Mathilde Haugaard, Mette Flethøj, Eva Zander Hesselkilde, Jørgen K Kanters, Steen Pehrson, Rikke Buhl, Thomas Jespersen
BACKGROUND: Antiarrhythmic compounds against atrial fibrillation (AF) often have reduced efficacy and may display cardiac and/or non-cardiac toxicity. Efficacy can be improved by combining two compounds with distinct mechanisms, and it may be possible to use lower doses of each compound, thereby reducing the likelihood of adverse side-effects. The purpose of this study was to investigate whether the effective doses of dofetilide and ranolazine can be reduced if the drugs are combined...
October 25, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29064846/pre-and-post-conditioning-by-cardiac-glycosides-in-the-mouse-heart
#20
Qiming Duan, Yunhui Xu, Pauline Marck, Jennifer Kalisz, Eric E Morgan, Sandrine V Pierre
Ouabain preconditioning (OPC) initiated by low concentrations of the cardiac glycoside (CG) ouabain binding to Na/K-ATPase is relayed by a unique intracellular signaling and protects cardiac myocytes against ischemia/reperfusion (IR) injury. To explore more clinically applicable protocols based on CG properties, we tested whether the FDA-approved CG digoxin could trigger cardioprotective effects comparable to those of ouabain using PC and PostC protocols in the Langendorff-perfused mouse heart subjected to global ischemia and reperfusion...
October 23, 2017: Journal of Cardiovascular Pharmacology
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