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Journal of Cardiovascular Pharmacology

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https://www.readbyqxmd.com/read/27875385/effects-of-linagliptin-on-vessel-wall-healing-in-the-rat-model-of-arterial-injury-under-normal-and-diabetic-conditions
#1
Linnea Eriksson, Samuel Röhl, Robert Saxelin, Mariette Lengquist, Malin Kronqvist, Kenneth Caidahl, Claes-Göran Östenson, Anton Razuvaev
Diabetic patients suffer an increased risk of restenosis and late stent thrombosis after angioplasty, complications that are related to a defective re-endothelialization. Dipeptidyl peptidase-4 inhibitors have been suggested to exert direct effect on endothelial and smooth muscle cells (SMCs). Therefore the objective was to study if the dipeptidyl peptidase-4 inhibitor linagliptin could influence vascular repair and accelerate re-endothelialization after arterial injury in healthy and diabetic animals. Diabetic Goto-Kakizaki and healthy Wistar rats were subjected to arterial injury and treated with linagliptin or vehicle...
November 17, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27851698/nitrite-prevents-right-ventricular-failure-and-remodeling-induced-by-pulmonary-artery-banding
#2
Jian Hu, Maryam Sharifi-Sanjani, Stevan P Tofovic
BACKGROUND: Nitrite has been shown to reduce right ventricle (RV) remodeling in experimental pulmonary hypertension. However, whether this effect is due to a reduction in RV afterload (i.e., reduction in pulmonary artery pressure) or a direct effect on the RV itself remains unanswered. We hypothesize that nitrite has direct effects on RV remodeling and studied its effects in mice with pulmonary artery banding (PAB). METHODS AND RESULTS: PAB decreased exercise tolerance, and reduced RV systolic and diastolic function...
November 14, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27851697/preventing-publication-of-falsified-and-fabricated-data-roles-of-scientists-editors-reviewers-and-readers
#3
Sanne M Korte, Marcel A G van der Heyden
Recently, the Journal of Cardiovascular Pharmacology retracted two papers for figure irregularities. In an attempt to reduce the number of such cases in future, we provide insights in a number of existing control mechanisms for scientists, editors, reviewers and readers, in the process of scholarly publication. We encourage case-based education using very recent examples from literature, implementation of early detection measures in the editorial and peer review processes, and finally, we emphasize the value of post-publication quality control by readers and means to assist them in such endeavors...
November 14, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27828791/efficacy-and-safety-of-vernakalant-for-cardioversion-of-recent-onset-atrial-fibrillation-in-the-asia-pacific-region-a-phase-3-randomized-controlled-trial
#4
Gregory N Beatch, Kiran Bhirangi, Steen Juul-Moller, Jörg Rustige
Atrial fibrillation (AF) is a common clinically significant cardiac arrhythmia. This phase 3 randomized, double-blind, placebo-controlled trial assessed the efficacy and safety of vernakalant hydrochloride for the pharmacological conversion of AF to sinus rhythm (SR) in patients with recent-onset (>3 hours-≤7 days) symptomatic AF from the Asia-Pacific region. Patients received an infusion of vernakalant (3 mg/kg) or placebo over 10 minutes. If AF had not been terminated 15 minutes later, a second infusion of vernakalant (2 mg/kg) or placebo 15 minutes was administered...
November 7, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27798416/effect-of-free-and-nanoencapsulated-copaiba-oil-on-monocrotaline-induced-pulmonary-arterial-hypertension
#5
Cristina Campos, Alexandre Luz de Castro, Angela Maria Vicente Tavares, Rafael Oliveira Fernandes, Vanessa Duarte Ortiz, Tatiane Evelyn Barboza, Cláudio Pereira, Miriam Apel, Onilda Santos da Silva, Susana Llesuy, Alex Sander da Rosa Araujo, Adriane Belló-Klein
Copaiba oil comes from an Amazonian tree and has been used as an alternative medicine in Brazil. However, it has not been investigated yet in the treatment of cardiovascular diseases. This study was designed to test whether copaiba oil or nanocapsules containing this oil could modulate monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). Male Wistar rats (170 ± 20 g) received oil or nanocapsules containing this oil (400 mg/kg) by gavage daily for one week. At the end of this period, a single injection of MCT (60 mg/kg i...
October 28, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27828790/naoxintong-enhances-atorvastatin-induced-plaque-stability-while-ameliorating-atorvastatin-induced-hepatic-inflammation
#6
Xiaoxiao Yang, Yan Li, Lei Sun, Ying Liu, Chuanrui Ma, Yuanli Chen, Hao Tan, Qi Li, Xiaoju Li, Yong Wang, Yajun Duan, Buchang Zhao, Jihong Han
Buchang NaoXinTong (NXT) is a Chinese medicine which has been used for many years for treatment of patients with coronary heart disease (CHD) in China. Statins substantially reduce hypercholesterolemia and CHD mortality and morbidity. However, there is still a lot of CHD patients do not respond well to statin therapy. Herein, we report the effects of NXT on atorvastatin-inhibited atherosclerosis and atorvastatin-induced hepatic side effects. After 10 weeks high-fat diet (HFD) feeding, apoE deficient mice were randomly divided into 4 groups, and received the following treatment for another 8 weeks: group 1, HFD; group 2, HFD containing NXT; group 3, HFD containing atorvastatin; and group 4, HFD containing both NXT and atorvastatin...
October 26, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27798417/efficacy-of-zofenopril-compared-to-placebo-and-other-ace-inhibitors-in-patients-with-acute-myocardial-infarction-and-previous-cardiovascular-risk-factors-a-pooled-individual-data-analysis-of-four-randomized-double-blind-controlled-prospective-studies
#7
Claudio Borghi, Stefano Omboni, Giorgio Reggiardo, Stefano Bacchelli, Daniela Degli Esposti, Ettore Ambrosioni
In the SMILE 1, 3 and 4 studies early administration of zofenopril in acute myocardial infarction (AMI) showed to be prognostically beneficial vs. placebo or ramipril. The SMILE-2 showed that both zofenopril and lisinopril are safe and showed no significant differences in the incidence of major cardiovascular complications. In this pooled analysis of individual data of the SMILE studies we evaluated whether the superior efficacy of zofenopril is maintained also in patients with ≥1 cardiovascular risk factor (CV+, n=2962) as compared to CV- (n=668)...
October 7, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27753702/green-tea-polyphenol-epigallocatechin-3-gallate-alleviated-coxsackievirus-b3-induced-myocarditis-via-inhibiting-viral-replication-but-not-through-inhibiting-inflammatory-responses
#8
Xiran He, Bo Gao, Lei Zhou, Sidong Xiong
Viral myocarditis, which is mainly caused by coxsackievirus B3 (CVB3), affects about 5%-20% of the world population and still lacks efficient treatments. Green tea, a tonic and healthful beverage that was originated in ancient China, has been receiving considerable attention for its protective effect on cardiovascular diseases in recent years. In present investigation, we aimed to explore the effect of Green tea polyphenol epigallocatechin-3-gallate (EGCG) on CVB3-induced myocarditis and its underlying mechanism...
October 6, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27676327/chronic-sarpogrelate-treatment-reveals-5-ht7-receptor-in-the-serotonergic-inhibition-of-the-rat-vagal-bradycardia
#9
José Ángel García-Pedraza, Mónica García, María Luisa Martín, Nélida Eleno, Asunción Morán
5-hydroxytryptamine (5-HT) modulates the cardiac parasympathetic neurotransmission, inhibiting the bradyarrhythmia by 5-HT2 receptor activation. We aimed to determine whether the chronic selective 5-HT2 blockade (sarpogrelate) could modify the serotonergic modulation on vagal cardiac outflow in pithed rat. Bradycardic responses in rats treated with sarpogrelate (30 mg/kg.day; p.o.) were obtained by electrical stimulation of the vagal fibers (3, 6, and 9 Hz) or i.v. injections of acetylcholine (ACh; 1, 5, and 10 μg/kg)...
September 20, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27676326/tetramethylpyrazine-and-astragaloside-iv-synergistically-ameliorate-left-ventricular-remodeling-and-preserve-cardiac-function-in-a-rat-myocardial-infarction-model
#10
Chuying Wang, Yumei Li, Xinxin Yang, Shengnan Bi, Yajie Zhang, Dong Han, Dafang Zhang
Tetramethylpyrazine (TMP) and astragaloside IV (AGS-IV) are herbal ingredients that have been demonstrated in animal models to limit infarct size and protect cardiomyocytes in the acute phase of myocardial infarction (MI), yet their long-term cardio-protective effects have not been evaluated. In the present study, TMP and/or ASG-IV were administrated to rats for 14 days after MI. Echocardiography revealed that the left ventricular (LV) dimensions and cardiac function was preserved in the MI rats with TMP and ASG-IV treatment, compared to untreated MI rats...
September 20, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27676325/the-effect-of-chronic-activation-of-the-novel-endocannabinoid-receptor-gpr18-on-myocardial-function-and-blood-pressure-in-conscious-rats
#11
Asmaa I Matouk, Ashraf Taye, Mohamed A El-Moselhy, Gehan H Heeba, Abdel A Abdel-Rahman
While acute activation of the novel endocannabinoid receptor GPR18 causes hypotension, there are no reports on GPR18 expression in the heart or its chronic modulation of cardiovascular function. In this study, after demonstrating GPR18 expression in the heart, we show that chronic (2 weeks) GPR18 activation with its agonist abnormal cannabidiol (abn-cbd; 100 µg/kg/day; i.p) produced hypotension, suppressed the cardiac sympathetic dominance, and improved left ventricular (LV) function (increased the contractility index dp/dtmax, and reduced LV end diastolic pressure, LVEDP) in conscious rats...
September 20, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27652911/dexmedetomidine-depresses-sinoatrial-and-atrioventricular-nodal-function-without-any-change-in-atrial-fibrillation-inducibility
#12
Akinori Sairaku, Yukiko Nakano, Kazuyoshi Suenari, Takehito Tokuyama, Hiroshi Kawazoe, Hiroya Matsumura, Shunsuke Tomomori, Michitaka Amioka, Yasuki Kihara
It has been reported that dexmedetomidine (dex) has an impact on the cardiac conduction system and even has potential antiarrhythmic actions. We examined the influence of dex on the cardiac electrophysiological properties and atrial fibrillation (AF) inducibility. Adult paroxysmal AF patients were randomly assigned to receive (N=107) or not receive (N=108) dex during cardiac electrophysiological studies. The corrected sinus node recovery time (558±331 vs. 459±260ms; P=0.02), Wenckebach cycle length (P<0...
September 19, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27652910/inotropic-effects-of-prostacyclins-on-the-right-ventricle-are-abolished-in-isolated-rat-hearts-with-right-ventricular-hypertrophy-and-failure
#13
Sarah Holmboe, Asger Andersen, Jacob Johnsen, Jan Møller Nielsen, Rikke Nørregaard, Hans Erik Bøtker, Lucie H Clapp, Jens Erik Nielsen-Kudsk
BACKGROUND: Prostacyclin mimetics are vasodilatory agents used in the treatment of pulmonary arterial hypertension. The direct effects of prostanoids on right ventricular (RV) function are unknown. We aimed to investigate the direct effects of prostacyclin mimetics on RV function in hearts with and without RV hypertrophy and failure. METHODS: Wistar rats were subjected to pulmonary trunk banding to induce compensated RV hypertrophy (n=32) or manifest RV failure (n=32)...
September 19, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27824722/antioxidant-treatment-improves-cardiac-dysfunction-in-a-murine-model-of-premature-aging
#14
Bianca Hemmeryckx, Philipp Hohensinner, Melissa Swinnen, Ward Heggermont, Johann Wojta, Henri Roger Lijnen
Bmal1-(brain and muscle ARNT-like protein-1) deficient (Bmal1) mice prematurely age because of an increased reactive oxygen species (ROS) production. These mice also show a decline in cardiac function with age. We investigated whether an antioxidant treatment can ameliorate the declining cardiac function in prematurely aged Bmal1 mice. Male Bmal1 and wild-type (Bmal1) mice were exposed for 15 weeks to a high fat and high cholesterol diet with or without the antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPOL; 5 mmol/L; in drinking water during the last 10 weeks)...
November 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27824721/antiperoxynitrite-treatment-ameliorates-vasorelaxation-of-resistance-arteries-in-aging-rats-involvement-with-protection-of-circulating-endothelial-progenitor-cells
#15
Qi Sun, Yu Dong, Huanyuan Wang, Kun Jiao, Jiahui Xu, Lu Ma, Haixia Huang, Huirong Liu, Wen Wang
Numerous studies have found that the age-associated structural and functional alterations in arteries were characterized by increased endothelial dysfunction. In this study, young (3 months), adult (9 months), and aging (20 months) male Sprague-Dawley rats were randomly divided into 6 groups, including control groups and FeTMPyP (peroxynitrite scavenger) groups receiving saline and FeTMPyP, respectively, for 5 administrations once every 3 days through intraperitoneal injection. The aged-related proteins beta-galactosidase, p53, and p16 as well as the nitrotyrosine and endothelial marker endothelial nitric oxide synthase and von Willebrand factor (vWF) in vascular tissues were measured by immunohistochemistry...
November 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27525576/safety-of-immediate-release-nifedipine
#16
Laura Means, Scott T Benken, Eljim P Tesoro
Nifedipine immediate release (IR) is a short-acting dihydropyridine calcium channel blocker historically used for hypertensive crisis, but its use has decreased because of reports of adverse reactions such as myocardial infarction (MI), arrhythmias, and stroke. This was a retrospective evaluation of the safety of nifedipine IR in 122 patients at an academic medical center from January 1, 2009, to December 31, 2014. Patients were separated into high- and low-risk groups. High risk was defined as a medical history significant for arrhythmia, MI, or stroke...
November 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27760067/role-of-asymmetrical-dimethylarginine-in-diabetic-microvascular-complications
#17
Mei-Rong Du, Gui-Xia Ju, Nian-Sheng Li, Jun-Lin Jiang
Microvascular complications are the leading causes of acquired blindness, end-stage renal failure, and varieties of neuropathy associated with diabetes. Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, is involved in endothelial dysfunction, oxidative stress, and inflammation associated with the progression of diabetic microvascular complications. Elevated ADMA has been detected in experimental animals and patients with diabetic microangiopathy like retinopathy, nephropathy, and neuropathy...
October 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27760066/the-impact-of-allopurinol-on-patients-with-acute-st-elevation-myocardial-infarction-undergoing-thrombolytic-therapy
#18
Ahmad Separham, Samad Ghaffari, Hossein Najafi, Reza Ghaffari, Mojtaba Ziaee, Hossein Babaei
Allopurinol may have protective effects over ischemic reperfusion injury and reduce infarct size. In this randomized study, we aimed to evaluate the impact of allopurinol in patients with acute ST elevation myocardial infarction (STEMI) undergoing thrombolytic therapy. Overall, 140 patients with STEMI were randomly assigned to receive 400 mg of allopurinol or placebo before treating with streptokinase. Then, study group received 100 mg of allopurinol daily for 28 days and placebo group received placebo for the same period...
October 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27617699/tetrodotoxin-sensitive-ca2-currents-but-no-t-type-currents-in-normal-hypertrophied-and-failing-mouse-cardiomyocytes
#19
Ilona Bodi, Hiroyuki Nakayama, Arnold Schwartz
AIMS: To obtain functional evidence that ICa,T is involved in the pathogenesis of cardiac hypertrophy and heart failure. We unexpectedly identified ICa(TTX) rather than ICa,T, therefore, we adjusted our aim to encompass these findings. METHODS AND RESULTS: We investigated 1) Cav3.1 (α1G) transgenic (Tg) mice compared with non-transgenic (tTA-Ntg) 2) Cav3.1 deficient mice (Cav3.1) compared with wild-type (Wt) after chemically and surgically induced cardiac remodeling 3) Spontaneous hypertensive rats (SHR) and thoracic aorta constricting (TAC) rats...
September 7, 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27606935/puerarin-suppresses-na-k-atpase-mediated-systemic-inflammation-and-cd36-expression-and-alleviates-cardiac-lipotoxicity-in-vitro-and-in-vivo
#20
Hua Qin, Yan Zhang, Ru Wang, Xiaoyan Du, Liping Li, Haiwei Du
Puerarin, a type of isoflavone, was shown to have multiple protective effects on myocardial injury. The objective of this study was to investigate the role of puerarin in the progression of lipotoxic cardiomyopathy. Primary cardiomyocytes were isolated from FATP1 transgenic (Tg) mice with lipotoxic cardiomyopathy, and various concentrations of puerarin were used to incubate with the cardiomyocytes. Our results showed low dose puerarin (≤ 20 μM) treatment increased the cell viability and decreased the accumulation of free fatty acid (FFA)...
September 6, 2016: Journal of Cardiovascular Pharmacology
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