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Journal of Cardiovascular Pharmacology

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https://www.readbyqxmd.com/read/29787401/the-melatonin-receptor-agonist-ramelteon-reduces-ischemia-reperfusion-injury-via-activation-of-mitochondrial-potassium-channels
#1
Martin Stroethoff, Iris Christoph, Friederike Behmenburg, Annika Raupach, Sebastian Bunte, Semra Senpolat, André Heinen, Markus W Hollmann, Alexander Mathes, Ragnar Huhn
Activation of melatonin receptors induces cardioprotection. Mitochondrial potassium channels (mKCa and mKATP) are involved in the signalling cascade of preconditioning. The melatonin receptor agonist ramelteon is an approved oral medication for treatment of insomnia but nothing is known about possible cardioprotective properties. We investigated whether (1) ramelteon induces cardioprotection mediated by the melatonin receptor; (2) this effect is concentration-dependent; and (3) mKCa- and/or mKATP-channels are critically involved in ramelteon-induced cardioprotection...
May 21, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29738373/ivabradine-s-pleiotropic-profile-can-it-protect-against-doxorubicin-induced-heart-failure
#2
Richard L Verrier
No abstract text is available yet for this article.
May 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29738372/paradoxical-effects-of-sodium-calcium-exchanger-inhibition-on-torsade-de-pointes-and-early-afterdepolarization-in-a-heart-failure-rabbit-model
#3
Po-Cheng Chang, Yu-Ying Lu, Hui-Ling Lee, Shien-Fong Lin, Yen Chu, Ming-Shien Wen, Chung-Chuan Chou
Calcium homeostasis plays an important role in development of early afterdepolarizations (EADs) and torsade de pointes (TdP). The role of sodium-calcium exchanger (NCX) inhibition in genesis secondary Ca rise and EADs-TdP is still debated. Dual voltage and intracellular Ca optical mapping were conducted in 6 control and 9 failing rabbit hearts. After baseline electrophysiological and optical mapping studies, E4031 was given to simulate long QT syndrome. ORM-10103 was then administrated to examine the electrophysiological effects on EAD-TdP development...
May 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29738371/apoa-1-mimetic-peptide-elk-2a2k2e-decreases-inflammatory-factor-levels-via-the-abca1-jak2-stat3-ttp-axis-in-thp-1-derived-macrophages
#4
Jia-Lin Wang, Duo Gong, Xin-Yan Hu, Su Wu, Xi-Long Zheng, Jie Wu, Xiao-Er Tang, Da-Wei Zhang, Chao-Ke Tang
OBJECTIVE: The aim of this study was to determine whether the apolipoprotein A-1 (apoA-1) mimetic peptide ELK-2A2K2E regulates inflammatory cytokine expression via activating the ATP-binding cassette transporter A1 (ABCA1)-janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3)- tristetraprolin (TTP) signaling pathway in THP-1 macrophage-derived foam cells. METHODS AND RESULTS: The cells were treated with the apoA-1 mimetic peptide ELK-2A2K2E at different concentrations (0, 20, 40, 80 μg/ml) or incubated with ELK-2A2K2E (40 μg/ml) for different times (0, 6, 12, 24 h)...
May 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29738370/biologics-and-cardiovascular-disease
#5
John S Van Taunay, M Teresa Albelda, Juan Carlos Frias, Michael J Lipinski
The advent of biologic therapy has enhanced our ability to augment disease in an increasingly targeted manner. The use of biologics in cardiovascular disease (CVD) has steadily increased over the past several decades. Much of the early data on biologics and CVD were derived from their use in rheumatologic populations. Atherosclerosis, myocardial infarction, and heart failure have been closely linked to the inflammatory response. Accordingly, cytokines such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 have been targeted...
May 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29738369/cardioprotective-effects-of-metformin
#6
Christine Driver, Kayode Dominion Samuel Bamitale, Aniessa Kazi, Mehnaaz Olla, Annah Ntsoaki Nyane, Peter Mark Oroma Owira
Metformin, routinely used as first-line drug in the treatment of type 2 diabetes has been shown to have cardioprotective effects beyond its glycemic control. These have been attributed to increases in Akt concentrations and activation of protein kinases in the RISK pathways. which prevent the mitochondrial mPTP from opening and rupturing it and therefore protects myocyte viability. In myocardial infarction and subsequent reperfusion, metformin activation of AMPK promotes glycolysis and keeps the mPTP closed...
May 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29738368/anti-apoptotic-effect-of-%C3%AE-1-blockers-in-ascending-thoracic-aortic-smooth-muscle-cells-the-role-of-hsp70-expression
#7
Ioannis K Rizos, James N Tsoporis, Ioannis K Toumpoulis, Vasileios Salpeas, Shehla Izhar, Angelos G Rigopoulos, Eleftherios A Sakadakis, Thomas G Parker
Heat shock proteins (HSP) play an important role in the cellular adaptation to stress, a requisite for cell survival. The aortic wall appears to be a target for increased expression of HSP during surgical stress. We aimed to define the expression and function of aortic HSP70 in 31 patients with normal ascending thoracic aortic diameter who underwent aortic valve replacement due to aortic valve stenosis (AVS) and in 35 patients with dilated ascending thoracic aorta who underwent replacement of an ascending thoracic aortic aneurysm (ATAA)...
May 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29738374/effect-of-interleukin-1-blockade-on-left-ventricular-systolic-performance-and-work-a-post-hoc-pooled-analysis-of-two-clinical-trials
#8
Leo F Buckley, Salvatore Carbone, Cory R Trankle, Justin M Canada, Claudia Oddi Erdle, Jessica A Regan, Michele M Viscusi, Dinesh Kadariya, Hayley Billingsley, Ross Arena, Antonio Abbate, Benjamin W Van Tassell
BACKGROUND: Interleukin-1 (IL-1) blockade appears to improve anaerobic exercise in patients with systolic heart failure through improved left ventricular systolic performance. However, it is unclear whether IL-1 blockade affects left ventricular systolic performance. METHODS: We pooled data from two clinical trials of patients with systolic heart failure who were randomized to IL-1 blockade or placebo. We estimated changes in left ventricular systolic performance (left ventricular ejection fraction [LVEF] and end-systolic elastance [LVEes]) and pressure-volume area, a surrogate of oxygen consumption, after 14 days of treatment...
April 30, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29738377/proton-pump-inhibition-in-patients-treated-with-novel-antithrombotic-drugs-should-we-worry-about-thrombosis
#9
Tomáš Bolek, Matej Samoš, Ingrid Škorňová, Frantisek Kovář, Peter Galajda, Ján Stasko, Peter Kubisz, Marián Mokáň
Proton pump inhibition (PPI) administrated together with antiplatelet and anticoagulant agents reduces the risk of gastrointestinal hemorrhage. Several novel antithrombotic agents have been recently introduced for acute coronary syndrome patients (prasugrel, ticagrelor), or for patients requiring long-term anticoagulation (dabigatran, rivaroxaban, apixaban, edoxaban, betrixaban). In fact, these agents might offer even stronger inhibition of platelets or coagulation compared with older agents; and therefore, the need for gastroprotection might be even stronger when these new agents are used for long-term antithrombotic therapy...
April 24, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29738376/naoxintong-capsule-inhibits-carrageenan-induced-thrombosis-in-mice
#10
Qi Li, Yi Chen, Dan Zhao, Zhuo Wei, Shuang Zhang, Yuanli Chen, Yong Wang, Ke Qian, Buchang Zhao, Yan Zhu, Xiumei Gao, Pengzhi Dong, Xiaoju Li, Yajun Duan, Jihong Han, Xiaoxiao Yang
Formation of thrombosis is mainly associated with dysfunctions of endothelial cells. NaoXinTong capsule (NXT), a traditional Chinese medicine, has been demonstrated multiple protective effects on vascular systems. However, it is unknown the effect of NXT on thrombosis. In this study, we determined if NXT can inhibit carrageenan-induced thrombosis and the underlying mechanisms. Two days after carrageenan injection, severe thrombi were found in blood vessels of mouse tail and liver. In contrast, thrombi were substantially reduced by NXT treatment, and the reduction was associated with reduced serum tumor necrosis factor α and P-selectin levels...
April 24, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29738375/magnesium-citrate-protects-against-vascular-calcification-in-an-adenine-induced-crf-rat-model
#11
PhD Zhihui-Yao, M D Yang-Xu, M D Weidong-Ma, Xin-Yuan Sun, PhD Shan-Jia, M D Yang-Zheng, M D Xiaohuan-Liu, M D Yajie-Fan, M D Congxia-Wang
BACKGROUND: Hypomagnemia was identified as a strong risk factor for cardiovascular disease in patients with chronic renal failure (CRF). However, the effects of magnesium (Mg) on vascular calcification (VC) have not been fully elucidated. Thus we aim to determine the effects of Mg citrate (MgCit) on VC in CRF rats. METHODS: Rats were divided into 5 groups: group 1 (normal diet); group 2 (normal diet with MgCit); group 3 (VC model of CRF induced by 0.75% adenine and 0...
April 24, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29688913/the-possible-ameliorative-effect-of-ivabradine-on-the-autonomic-and-left-ventricular-dysfunction-induced-by-doxorubicin-in-male-rats
#12
Amany E El-Naggar, Sahar M El-Gowilly, Fouad M Sharabi
Heart failure is a common adverse effect associated with doxorubicin treatment. The aim of this study is to investigate the effect of ivabradine treatment on doxorubicin-induced heart failure in conscious rats. Rats were treated with doxorubicin (2.5 mg/kg/day) or ivabradine (10 mg/kg/day) alone or along with doxorubicin injections. Changes in heart rate variability (HRV), baroreflex sensitivity, left ventricular function, serum cardiac troponin T and cardiac histological features were taken as index parameters for the development of heart failure...
April 20, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29688912/tilianin-loaded-ros-scavenging-nano-micelles-protect-h9c2-cardiomyocyte-against-hypoxia-reoxygenation-induced-injury
#13
Yanfang Wang, Ying Wang, Xinchun Wang, Ping Hu
Previous studies have shown that Tilianin alleviates ischemia-reperfusion-induced cardiomyocyte injury. However, its clinical translation has been hampered because of its insolubility in water. Tilianin-based nano micelles that may overcome this critical issue are presented. A polyethylene glycol compound (PEG) was covalently attached to propylene sulfide formed amphiphilic diblock polymers. In the aqueous solution, tilianin is encapsulated in a hydrophobic shell to form nano micelles. The Ph-PPS-PEG self-assembled into nanoscale micelles with a size of approximately 70 nm, termed tilianin loaded micelles (TLMs)...
April 20, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29688911/tranilast-blunts-the-hypertrophic-and-fibrotic-response-to-increased-afterload-independent-of-cardiomyocyte-transient-receptor-potential-vanilloid-2-channels
#14
Sheryl E Koch, Michelle L Nieman, Nathan Robbins, Samuel Slone, Mariah Worley, Lisa C Green, Yamei Chen, Alexandria Barlow, Michael Tranter, HongSheng Wang, John N Lorenz, Jack Rubinstein
Tranilast is clinically indicated for the treatment of allergic disorders and is also a non-selective blocker of the Transient Receptor Potential Vanilloid 2 (TRPV2) channel. Prior studies have found that it has protective effects in various animal models of cardiac disease. Our laboratory has found that genetic deletion of TRPV2 results in a blunted hypertrophic response to increased afterload, thus this study tested the hypothesis that tranilast through cardiomyocyte TRPV2 blockade can inhibit the hypertrophic response to pressure overload in-vivo via transverse aortic constriction and ex vivo via isolated myocyte studies...
April 20, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29668531/correlation-between-extended-leukocyte-differential-count-and-coronary-artery-disease
#15
Si Chen, Shulan Zhang, Haixia Luan, Xiaoli Zeng, Yongzhe Li, Hui Yuan
BACKGROUND: Leukocyte count is closely associated with the risk of coronary artery disease (CAD). Levels of leukocyte subpopulations in CAD patients, however, remain largely unknown. METHODS: In the present study, we compared the distributions and counts of 16 leukocyte subpopulations between 40 CAD patients and 40 healthy controls using the CytoDiff flow cytometric system. RESULTS: Our results demonstrated significant increases in the frequencies and counts of all monocytes, immature granulocytes and B-lymphocytes in CAD patients, suggesting the levels of these leukocyte subpopulations may serve as potential biomarkers for diagnosis of CAD...
April 10, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29642134/effect-of-diallyl-trisulfide-on-ischemic-tissue-injury-and-revascularization-in-a-diabetic-mouse-model
#16
Hai-Bing Yang, Hui-Min Liu, Jin-Chuan Yan, Zhao-Yang Lu
BACKGROUND AND OBJECTIVE: Allitridin (diallyl trisulfide, DATS) is an extract from garlic (Allium sativum) that putatively improves endothelial function and is protective against cardiovascular diseases. Endothelial dysfunction after tissue ischemia in diabetic patients is partially due to poor angiogenic response. This study investigated whether DATS may improve angiogenesis in a diabetic mouse model with hind limb ischemia. METHODS: Streptozotocin (STZ) was administered by intraperitoneal injection to establish the model of diabetes in male C57BL/6 mice...
April 10, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29672418/perioperative-use-of-levosimendan-improves-clinical-outcomes-in-patients-post-cardiac-surgery-a-systematic-review-and-meta-analysis
#17
Hua Qiang, Xiu Luo, Jian-Hua Huo, Zhi-Quan Wang
Severe postoperative complications can affect cardiac surgery patients. Levosimendan is a novel calcium sensitizer commonly administered after cardiac surgery. However, the patient benefits are controversial. PubMed, Embase, and the Cochrane library were systematically searched for randomized controlled trials (RCTs) comparing levosimendan with control in adult cardiac surgery patients. Twenty-five studies (3247 patients) were included. Pooled data indicated that levosimendan reduced mortality after cardiac surgery (OR 0...
April 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29634656/inhibiting-the-inflammatory-injury-following-myocardial-ischemia-reperfusion-with-plasma-derived-%C3%AE-1-anti-trypsin-a-post-hoc-analysis-of-the-vcu-%C3%AE-1rt-study
#18
Nayef Antar Abouzaki, Sanah Christopher, Cory Trankle, Benjamin Wallace Van Tassell, Salvatore Carbone, Adolfo Gabriele Mauro, Leo Buckley, Stefano Toldo, Antonio Abbate
BACKGROUND: Despite the benefits of reperfusion in limiting myocardial injury, the infarct size continues to expand after reperfusion due to secondary inflammatory injury. Plasma derived α-1 anti-trypsin (AAT) inhibits the inflammatory injury in myocardial ischemia and reperfusion. To explore the effects of plasma-derived AAT on the inflammatory response to ischemia-reperfusion injury, we analyzed time-to-reperfusion and enzymatic infarct size estimates in a post-hoc analysis of the VCU-α1RT clinical trial (clinicaltrials...
March 23, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29621036/comparative-evaluation-of-gemcabene-and-ppar-ligands-in-transcriptional-assays-of-peroxisome-proliferator-activated-receptors-implication-for-the-treatment-of-hyperlipidemia-and-cardiovascular-disease
#19
Charles L Bisgaier, Daniela C Oniciu, Rai Ajit K Srivastava
Gemcabene, a late-stage clinical candidate, has shown efficacy for LDL-C, non-HDL cholesterol, apoB, triglycerides and hsCRP reduction, all risk factors for cardiovascular disease (CVD). In rodents, gemcabene showed changes in targets, including apoC-III, apoA-I, peroxisomal enzymes, considered regulated via PPAR gene activation, suggesting a PPAR-mediated mechanism of action for the observed hypolipidemic effects observed in rodents and humans. In the current study, the gemcabene agonist activity against PPAR subtypes of human, rat and mouse were compared to known lipid lowering PPAR activators...
March 21, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29634657/muramyl-dipeptide-mdp-induces-reactive-oxygen-species-ros-generation-via-the-nod2-cox-2-nox4-signaling-pathway-in-human-umbilical-vein-endothelial-cells-huvecs
#20
Ling-Jun Kong, Xiao-Qian Liu, Ying Xue, Wei Gao, Qian-Zhou Lv
Vascular endothelium dysfunction caused by oxidative stress accelerates the pathologic process of cardiovascular diseases. NOD2, an essential receptor of innate immune system, has been demonstrated to play a critical role in atherosclerosis. Here, the aim of our study was to investigate the effect and underlying molecular mechanism of muramyl dipeptide (MDP) on NOX4-mediated ROS generation in human umbilical vein endothelial cells (HUVECs). 2,7-dichlorofluorescein diacetate staining was to measure the intracellular ROS level and showed MDP promoted ROS production in a time- and dose-dependent manner...
March 20, 2018: Journal of Cardiovascular Pharmacology
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