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Indian Journal of Pharmacology

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https://www.readbyqxmd.com/read/30166754/erratum-effect-of-aluminum-chloride-on-blood-glucose-level-and-lipid-profile-in-normal-diabetic-and-treated-diabetic-rats
#1
(no author information available yet)
[This corrects the article on p. 357 in vol. 49, PMID: 29515276.].
May 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30166753/-teaching-experience-and-research-publications-quantity-matters-and-quality-suffers-a-medical-teacher-perspective
#2
LETTER
Sunil M Doshi
No abstract text is available yet for this article.
May 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30166752/social-desirability-bias-a-confounding-factor-to-consider-in-survey-by-self-administered-questionnaire
#3
LETTER
Himel Mondal, Shaikat Mondal
No abstract text is available yet for this article.
May 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30166751/etoricoxib-induced-toxic-epidermal-necrolysis-a-fatal-case-report
#4
Sukalyan Saha Roy, Shatavisa Mukherjee, Nikhil Era, Mala Mukherjee
Cyclooxygenase inhibitors were developed in the quest of enhanced analgesic efficacy devoid of gastric side effects. High usage of etoricoxib by prescription as well as self-administered routes has led to increasing reports of side effects and adverse reactions including dermatologic reactions in 0.1%-0.3% of cases. The present report enumerates a case of toxic epidermal necrolysis induced by etoricoxib.
May 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30166750/phytochemical-screening-antioxidant-antityrosinase-and-antigenotoxic-potential-of-amaranthus-viridis-extract
#5
Sima Kumari, R Elancheran, Rajlakshmi Devi
OBJECTIVE: Amaranthus viridis ( Amaranthaceae ) widely distributed all over the world, growing under a wide range of climatic conditions and has been utilized as a medicinal herb in traditional Ayurvedic medicine as antipyretic agents, also for the treatment of inflammation, ulcer, diabetic, asthma and hyperlipidemia. The aim of the study was designed to evaluate the chemical composition and antioxidant and biological properties of different fractions obtained from A. viridis . MATERIALS AND METHODS: Four different extracts of A...
May 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30166749/gas-chromatography-coupled-to-mass-spectrometry-characterization-anti-inflammatory-effect-wound-healing-potential-and-hair-growth-promoting-activity-of-algerian-carthamus-caeruleus-l-asteraceae
#6
Mohammed Mahdi Dahmani, Razika Laoufi, Okba Selama, Karim Arab
OBJECTIVES: The roots of Carthamus caeruleus have been used by the population of Northern Algeria to treat several pathological conditions, including wound healing and hair growth. The present study was conducted to evaluate the anti-inflammatory activity, wound-healing potential, and hair growth-promoting activity attributed to C. caeruleus root. MATERIALS AND METHODS: In this study, we have investigated the anti-inflammatory effect using carrageenan-induced paw edema test, evaluated the wound-healing potential by linear incision wound model, and evaluated hair growth activity using in vivo hair growth-promoting test attributed to C...
May 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30166748/apoptosis-induction-in-cancer-cell-lines-by-the-carotenoid-fucoxanthinol-from-pseudomonas-stutzeri-jgi-52
#7
Megha Shukla, Kilingar Nadumane Varalakshmi
CONTEXT: Microorganisms produce a variety of pigments and many pigments from bacteria were reported to have therapeutic potential including anticancer effects. AIM: The aim of this study is to evaluate the anticancer potential a yellow pigment from newly isolated Pseudomonas stutzeri JGI 52. MATERIALS AND METHODS: Serial dilution method was adopted for the isolation of pigmented bacteria from soil sources. Pigment extraction was carried out from bacterial isolates using methanol as the solvent and the pigment was purified by thin layer chromatography...
May 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30166747/-in-vivo-anticlastogenic-effect-of-silymarin-from-milk-thistle-silybum-marianum-l
#8
Sirajudheen Anwar, Hafez R Madkor, Nafees Ahmed, Mohamed E Wagih
OBJECTIVE: Silymarin, extracted from the seeds of Silybum marianum L. (Milk thistle), is traditionally used for treating various illnesses such as diabetes, cancer, inflammation, hepatitis, liver cirrhosis, and renal problems. Acute cytotoxicity and genotoxicity studies have been reported with ambiguous outcomes; however, its relevant anticlastogenic potential is not yet evaluated. This study was aimed to evaluate in vivo subacute anticlastogenic properties of silymarin to validate its use as a medicinal agent...
May 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30166746/mhealth-technologies-in-clinical-trials-opportunities-and-challenges
#9
EDITORIAL
Ashish Kumar Kakkar, Phulen Sarma, Bikash Medhi
No abstract text is available yet for this article.
May 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30100660/clinical-trials-waiver-in-india-some-considerations
#10
LETTER
Atul Juneja, Tulsi Adhikari
No abstract text is available yet for this article.
March 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30100659/well-tolerated-oral-cyclosporine-in-a-case-of-hypersensitivity-to-parenteral-cyclosporine-in-postallogeneic-bone-marrow-transplantation
#11
Mahsa Moeinian, Hamed Sotoude, Zahra Mohebbi, Ali Asadollahi-Amin, Rambod Mozafari
Cyclosporine is one of the main drugs used for the prophylaxis of graft versus host disease in bone marrow transplanted patients. Hypersensitivity reaction to intravenous cyclosporine is rare and might be due to its vehicle polyoxyethylated castor oil, Cremophor EL. The exact mechanism is unknown, but IgE and IgG antibodies, complement, and histamine release have been considered to play a role in the development of this reaction. Here, we describe a case of anaphylaxis to intravenous cyclosporine, which was developed in a 19-year-old Iranian female with acute myeloid leukemia who underwent allogeneic bone marrow transplantation from her sister...
March 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30100658/is-inhaled-glucocorticoids-the-only-culprit-in-angina-bullosa-hemorrhagica
#12
Ahu Yorulmaz, Basak Yalcin
Angina bullosa hemorrhagica (ABH) is an infrequent dermatosis characterized by acute onset of hemorrhagic bulla in the oral cavity. Clinical presentation of ABH may be quite worrisome, and clinicians often feel skeptical regarding their clinical diagnosis and lack confidence in managing this distinct entity. Indeed, ABH is a completely benign and self-limited disorder. The exact etiopathogenesis of ABH is still unknown. There have been reports in the literature addressing a central role for mechanical instability of the epithelial-connective tissue connection in the pathogenesis of ABH...
March 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30100657/clozapine-induced-bicytopenia-an-unusual-side-effect
#13
Abhijeet D Faye, Vivek C Kirpekar, Rahul Tadke, Sushil Gawande, Sudhir H Bhave
Agranulocytosis is a rare documented side effect of clozapine which can be associated with grave consequences. When it is associated with other blood dyscrasia, prognosis worsens further. In literature, there are very few cases of pancytopenia and bicytopenia caused by clozapine. We present a case of bicytopenia (reduced white and red blood cells' counts) caused by clozapine within a month of therapy and complicated by a Klebsiella pneumoniae infection. Patient improved in 3 weeks after stopping clozapine along with medical management in the Intensive Care Unit...
March 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30100656/potentiation-of-pentylenetetrazole-induced-neuronal-damage-by-dimethyl-sulfoxide-in-chemical-kindling-model-in-rats
#14
Puja Kumari, Neha Singh, Lekha Saha
OBJECTIVES: Dimethyl sulfoxide (DMSO) is commonly used as a vehicle for many hydrophobic drugs. This study aimed at evaluating the effect of low dose of DMSO (0.1%) on Pentylenetetrazole(PTZ) induced neuronal damage in rats. MATERIALS AND METHODS: Young male Wistar rats (n = 32) were divided into four groups as follows: saline control group, DMSO control group, PTZ group (35 mg/kg), and combination group (DMSO + PTZ). Animals were observed for seizure score, latency to develop kindling, percentage of animals kindled, and histopathological score of hippocampus...
March 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30100655/pharmacokinetics-and-bioavailability-of-chromium-malate-and-its-influence-on-trace-metals-absorption-after-oral-or-intravenous-administration
#15
Weiwei Feng, Qian Li, Wei Wang, Ting Zhao, Yun Feng, Fang Li, Guanghua Mao, Yao Chen, Yangyang Ding, Liuqing Yang, Xiangyang Wu
OBJECTIVES: In our preliminary study, chromium malate could decrease the blood glucose level in mice with diabetes and exhibits good benefits in treating glycometabolism and adipose metabolization obstacle in rats with type 2 diabetes. This study was aimed at assessing the pharmacokinetics and bioavailability of chromium malate and influence on trace metals absorption in rats. METHODS: BAPP 2.3 pharmacokinetic calculating program (China Pharmaceutical University Medicine Center) was used to calculate the pharmacokinetic parameters...
March 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30100654/incidence-of-multidrug-resistance-and-extended-spectrum-beta-lactamase-expression-in-community-acquired-urinary-tract-infection-among-different-age-groups-of-patients
#16
Sakina Fatima, Iyad Neeam Muhammad, Shahnaz Usman, Subia Jamil, Muhammad Naseem Khan, Seema Ismat Khan
OBJECTIVES: Urinary tract infection (UTI) is a frequent disorder and depends on age and gender. Ineffective empiric treatment of UTI is common when associated with extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae . The aim of the study was to investigate the prevalence of Gram-negative uropathogens of E. coli and K. pneumoniae in different age groups along with the identification of ESBL-producing uropathogens and antimicrobial susceptibility profiles...
March 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30100653/metabolic-syndrome-associated-cognitive-decline-in-mice-role-of-minocycline
#17
Aniruddha Mukherjee, Bina K Mehta, Kalyan K Sen, Sugato Banerjee
OBJECTIVE: The objective of the study was to characterize the mechanism associated with metabolic syndrome (MetS)-associated cognitive decline and determine the effect of minocycline on the above condition in mice. MATERIALS AND METHODS: We developed a HFHC diet-induced MetS model in mice. Diagnostic characteristics of MetS including waist circumference, lipid levels, blood pressure, and fasting blood glucose were measured in these Swiss albino mice. Cognitive parameters were measured using passive avoidance and elevated plus maze test...
March 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/30100652/intellectual-property-rights-and-indian-pharmaceutical-industry-present-scenario
#18
EDITORIAL
Ajay Prakash, Phulen Sarma, Subodh Kumar, Bikash Medhi
No abstract text is available yet for this article.
March 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29861527/is-tapentadol-a-potential-trojan-horse-in-the-postdextropropoxyphene-era-in-india
#19
Aniruddha Basu, Jayant Mahadevan, Dhruva Ithal, Sowmya Selvaraj, Prabhat Kumar Chand, Pratima Murthy
Tapentadol is a centrally acting opioid analgesic which has partial opioid agonistic and norepinephrine reuptake inhibitor action similar to its nearest congener and tramadol though with a relatively higher μ-affinity. It has abuse potential, is a scheduled drug, yet currently is not known to be an opioid widely misused in India. However, under the current drug abuse legislation in India, where common prescription opioids such as dextropropoxyphene have been banned, tapentadol may take the center stage of pharmaceutical opioid abuse in the near future...
January 2018: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29861526/levetiracetam-use-during-pregnancy-in-women-with-epilepsy-preliminary-observations-from-a-tertiary-care-center-in-northern-india
#20
Ramandeep Bansal, Vanita Suri, Seema Chopra, Neelam Aggarwal, Pooja Sikka, Subhas Chandra Saha, Manoj Kumar Goyal, Praveen Kumar
INTRODUCTION: Data on efficacy and safety of levetiracetam (LEV) during pregnancy is still limited. We analyzed efficacy and safety of LEV during pregnancy in North Indian women with epilepsy (WWE) which is being presented here. PATIENTS AND METHODS: This retrospective study included 99 WWE (on treatment with a single antiepileptic drug [AED]) who were evaluated in medical-surgical disorder antenatal clinic of the department of obstetrics and gynecology at a tertiary care teaching hospital and referral center in North India...
January 2018: Indian Journal of Pharmacology
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