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Indian Journal of Pharmacology

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https://www.readbyqxmd.com/read/29674803/iatrogenic-metrorrhagia-after-the-use-of-itraconazole-for-onychomycosis
#1
Piotr Brzezinski, Sandra Jerkovic Gulin, Dario Gulin, Anca Chiriac
We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia. The suggested probable mechanism is the inhibition of steroidogenesis, especially estrogens that resulted in low-estrogen breakthrough bleeding. This article emphasizes the importance of drug interaction check prior the initiation of onychomycosis treatment.
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674802/dried-urine-spots-for-detection-of-benzodiazepines
#2
Raka Jain, Rizwana Quraishi, Atul Ambekar, Arpita Verma, Pratibha Gupta
BACKGROUND AND AIM: Benzodiazepines (BZD) are widely prescribed to substance users. However, the nonmedical use of prescription BZD often leads to abuse and dependence. Therefore, it is important to detect BZD among substance users seeking treatment. The aim of the present study was to develop an efficient method for testing BZD on dried urine spot (DUS) and evaluating its clinical applicability. METHODS: This involved optimization of conditions for the detection, recovery, and stability of BZD from dried urine, spotted on filter paper...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674801/immunomodulatory-properties-of-titanium-dioxide-nanostructural-materials
#3
T Sree Latha, Madhava C Reddy, Prasad V R Durbaka, Shankar V Muthukonda, Dakshayani Lomada
OBJECTIVES: Although titanium dioxide (TiO2 ) nanostructural materials have been widely used in Biology and Medicine, very little is known about immunomodulation mechanism of these materials. Objectives of this study are to investigate in vitro immunomodulatory effects of TiO2 . Immunosuppressant may lower immune responses and are helpful for the treatment of graft versus host diseases and autoimmune disorders. MATERIALS AND METHODS: In this study, we used H2 Ti3 O7 titanium dioxide nanotubes (TNT) nanotubes along with commercial TiO2 nanoparticles (TNP) and TiO2 fine particles (TFP)...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674800/olanzapine-versus-aprepitant-for-the-prophylaxis-of-chemotherapy-induced-nausea-and-vomiting-in-breast-cancer-patients-receiving-doxorubicin-cyclophosphamide-regimen-a-prospective-nonrandomized-open-label-study
#4
G Shivaprakash, Karthik S Udupa, V Sarayu, Joseph Thomas, Vishal Gupta, L C Pallavi, Sudhakar Pemminati
OBJECTIVE: Despite the guideline-directed therapy, complete absence of nausea was noted only in 33% of breast cancer patients on anthracycline-cyclophosphamide regimen. Hence, we sought to compare the efficacy of aprepitant (APT) versus olanzapine (OLP) in preventing chemotherapy-induced nausea and vomiting (CINV) in breast cancer patients on doxorubicin-cyclophosphamide regimen. PATIENTS AND METHODS: A prospective, open-label, nonrandomized study was conducted at the Department of Oncology...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674799/assessment-of-nonsteroidal-anti-inflammatory-drug-use-pattern-using-world-health-organization-indicators-a-cross-sectional-study-in-a-tertiary-care-teaching-hospital-of-chhattisgarh
#5
P R R Vaishnavi, Nitin Gaikwad, S P Dhaneria
OBJECTIVE: The objective of this study is to assess drug utilization pattern of nonsteroidal anti-inflammatory drugs (NSAIDs) in a tertiary care teaching hospital, Raipur, Chhattisgarh. MATERIALS AND METHODS: A prospective, cross-sectional observational study was conducted in the outpatient department during 2-month period. After informed consent, the patients visiting pharmacy shop with a prescription were enrolled in the study. Their demographic details and prescription data were recorded in a case record form...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674798/switching-of-antihypertensive-drugs-at-tertiary-care-government-hospital-hyderabad-india-a-cross-sectional-retrospective-investigation
#6
Varsha Varakantham, Ashok Kumar Kurakula Sailoo, Venkaiah Kodali, Dinesh Kumar Bharatraj
OBJECTIVE: Switching of antihypertensive drugs is attributed to uncontrolled blood pressure (BP) which imposes a great burden on health economics. But again, switching leads to accomplishment of the goal BP, thereby improving the health status. Such studies are well documented in developed nations but rarely reported in developing countries, especially in India. Therefore, the aim of this study was to evaluate various factors associated with switching of antihypertensive drugs. METHODS: A cross-sectional retrospective investigation was performed using a standardized schedule adapting the World Health Organization indicators for drug utilization in a tertiary care government hospital, Hyderabad, India...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674797/adverse-drug-reactions-at-adverse-drug-reaction-monitoring-center-in-raipur-analysis-of-spontaneous-reports-during-1-year
#7
Preeti Singh, Manju Agrawal, Rajesh Hishikar, Usha Joshi, Basant Maheshwari, Ajay Halwai
BACKGROUND: India is a developing country and adverse drug reactions (ADRs) influence most of the diseases in our population, and monitoring is required due to the paucity of ADRs. The present study was done to analyze the ADRs at the ADR monitoring center (AMC) of tertiary care hospital in Raipur during 1 year. MATERIALS AND METHODS: Study of ADR monitoring of outpatient and inpatient was a prospective and observational study carried out between September 2015 and August 2016...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674796/prescriber-and-dispenser-perceptions-about-antibiotic-use-in-acute-uncomplicated-childhood-diarrhea-and-upper-respiratory-tract-infection-in-new-delhi-qualitative-study
#8
Anita Kotwani, P C Joshi, Urmila Jhamb, Kathleen Holloway
OBJECTIVE: The objective of the study was to explore the prescribing practices, knowledge, and attitudes of primary care doctors and community pharmacists, regarding antibiotic use in acute upper respiratory tract infections (URTI) and diarrhea in children to better understand causes of misuse and identify provider suggestions to change such behavior. MATERIALS AND METHODS: Two focus group discussions (FGDs) each were conducted with primary care government doctors (GDs), private general practitioners (GPs), pediatricians, and community pharmacists in Delhi...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29674795/three-dimensional-drugs-a-new-era-in-the-pharmaceutical-development
#9
EDITORIAL
Harish Kumar, Ajay Prakash, Phulen Sarma, Bikash Medhi
No abstract text is available yet for this article.
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29515283/are-your-capsules-vegetarian-or-nonvegetarian-an-ethical-and-scientific-justification
#10
Ajay Prakash, Hariom Soni, Abhishek Mishra, Phulen Sarma
Capsules are important component of day to day health management. But recently an issue came up whether the capsule you are using is of vegetarian or non-vegetarian origin. Capsule shell can be divided into vegetarian and non-vegetarian origin on the basis of their origin. Gelatin capsule shell are typically of animal origin and HPMC or starch based shells are of vegetarian origin. CDSCO received one proposal to replace all non veg capsule with capsule of vegetarian origin. CDSCO has invited comments from different stakeholders regarding this...
September 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29515282/magnesium-valproate-induced-pedal-edema-on-chronic-therapy-a-rare-adverse-drug-reaction
#11
Himani Prajapati, Dinesh Kansal, Rajan Negi
Valproate-related pedal edema is usually regarded as a problem occurring after long-term administration of valproate. Valproate has been a drug of choice for the treatment of generalized or partial seizures as monotherapy or adjunctive therapy, bipolar disorder, for the prophylaxis of migraine headache in adults. This case report described patient-acquiring bilateral pedal edema after long-term use of magnesium valproate. Discontinuing valproate resulted in rapid improvement of the condition. This adverse reaction to the best of our knowledge is first reported a case of bilateral pedal edema cause by magnesium valproate in low dose...
September 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29515281/fatal-dapsone-hypersensitivity-syndrome-with-hypothyroidism-and-steroid-induced-diabetes-mellitus
#12
Sarayu Pai, Renuka Munshi, Chitra Nayak
Dapsone has been part of the World Health Organization multidrug therapy for the treatment of leprosy. While it has been efficacious in the management of leprosy, there are many patients who develop adverse drug reactions to the drug including life-threatening reactions such as dapsone hypersensitivity syndrome (DHS). We report a case of a patient who was prescribed dapsone as part of multidrug therapy for leprosy following which she developed DHS. Her condition worsened after tapering the oral steroids given to manage the DHS, and she was detected to have hypothyroidism...
September 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29515280/pediatric-pharmacovigilance-in-an-institute-of-national-importance-journey-has-just-begun
#13
Pramod Kumar Sharma, Arup Kumar Misra, Neeraj Gupta, Daisy Khera, Ajay Gupta, Pushpinder Khera
OBJECTIVE: The objective of this study is to determine the nature and severity of adverse drug reactions (ADRs) in pediatric patients. MATERIALS AND METHODS: In this retrospective cohort study, we extracted the data from all the available pediatric ADR forms submitted to ADR monitoring center (AMC) from May 2014 to December 2016. The data including nature, frequency, causality (World Health Organization [WHO] causality scale), and the severity (Hartwig and Siegel scale for severity) of ADR were extracted...
September 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29515279/comparison-of-clinical-effectiveness-and-safety-of-newer-nonsteroidal-anti-inflammatory-drugs-in-patients-of-osteoarthritis-of-knee-joint-a-randomized-prospective-open-label-parallel-group-study
#14
Yashika Garg, Jatinder Singh, H S Sohal, Rajeshwari Gore, Arun Kumar
OBJECTIVE: Osteoarthritis (OA) is a chronic progressive degenerative disease of weight-bearing joints and the leading cause of disability in elderly. Current medical management of OA is mostly palliative with nonsteroidal anti-inflammatory drugs (NSAIDs) being the mainstay of therapy. Reports of gastrointestinal adverse effects with traditional NSAIDs and cardiovascular adverse effects associated with selective cyclooxygenase-2 (COX-2) inhibitors have prompted the hunt for a better NSAID with no or minimal adverse effects...
September 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29515278/comparison-of-online-reporting-systems-and-their-compatibility-check-with-respective-adverse-drug-reaction-reporting-forms
#15
Vikas Maharshi, Pravesh Nagar
AIM: Different forms and online tools are available in different countries for spontaneous reporting, one of the most widely used methods of pharmacovigilance. Capturing sufficient information and adequate compatibility of online systems with respective reporting form is highly desirable for appropriate reporting of adverse drug reactions (ADRs). This study was aimed to compare three major online reporting systems (US, UK, and WHO) of the world and also to check their compatibility with the respective ADR reporting form...
September 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29515277/sitagliptin-moringa-oleifera-coadministration-did-not-delay-the-progression-nor-ameliorated-functional-and-morphological-anomalies-in-alloxan-induced-diabetic-nephropathy
#16
Comfort Omoigemete Olurishe, Helen Ochuko Kwanashie, Abdulkadiri Umar Zezi, Nuhu Mohammed Danjuma, Bisalla Mohammed
OBJECTIVE: Sitagliptin (ST) and Moringa oleifera (MO) Lam (Moringaceae) are used concomitantly by diabetic patients, with no study ascertaining for potential favorable or otherwise renal implications. We investigated the effect of coadministration of ST and MO leaf extract on functional and morphological biomarkers of alloxan-induced diabetic nephropathy (DN). MATERIALS AND METHODS: Diabetes was induced with a single dose of 150 mg/kg of alloxan intraperitoneally...
September 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29515276/effect-of-aluminum-chloride-on-blood-glucose-level-and-lipid-profile-in-normal-diabetic-and-treated-diabetic-rats
#17
Venugopala Rao Konda, Madhavi Eerike, R Prasanth Chary, Ruckmani Arunachalam, Venkata Ramana Yeddula, Vinayak Meti, T Sobita Devi
OBJECTIVES: The objectives of the study were to assess evaluate the effects of aluminum chloride (AlCl3 ) on blood glucose and lipid levels in normal, diabetic, and glibenclamide-treated diabetic rats. MATERIALS AND METHODS: Forty-two male Wistar rats were divided into seven groups of six each. Group I was normal control, Groups II and III were given AlCl3 50 and 100 mg/kg, and Group IV to VII were administered with streptozotocin (STZ) (60 mg/kg) intraperitoneally...
September 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29515275/telmisartan-and-esculetin-combination-ameliorates-type-2-diabetic-cardiomyopathy-by-reversal-of-h3-h2a-and-h2b-histone-modifications
#18
Almesh Kadakol, Vajir Malek, Santosh Kumar Goru, Anuradha Pandey, Anil Bhanudas Gaikwad
OBJECTIVES: Although cardioprotective effects of telmisartan are well explored, its effects on epigenetic alterations associated with type 2 diabetic (T2D) cardiomyopathy remain unmapped. Thus, the present study was designed to evaluate the potential of esculetin and telmisartan combination to reverse histone posttranslational modifications (PTMs) in curbing T2D cardiomyopathy. MATERIALS AND METHODS: T2D was induced by high-fat diet feeding along with low dose of streptozotocin (35 mg/kg, I...
September 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29515274/incorporating-problem-based-learning-into-medical-curriculum-an-experience-from-a-medical-college-in-mangalore
#19
Nithin Kumar, Tanuj Kanchan, Bhaskaran Unnikrishnan, Rekha Thapar, Prasanna Mithra, Vaman Kulkarni, Ramesh Holla, Darshan Bhagwan, Yeshwanter Radhakrishnan
BACKGROUND: The Medical Council of India (MCI) has envisioned a change in the undergraduate medical curriculum by encouraging integrated teaching and Problem Based Learning (PBL). METHODS: In this cross-sectional study 110 medical teachers of Kasturba Medical College, Mangalore were assessed regarding their perception on PBL. Independent t -test was applied to find out the difference in the mean perception scores regarding PBL among the teachers in pre/para-clinical and clinical departments and P < 0...
September 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29515273/cosmetovigilance-in-india-need-of-the-day
#20
EDITORIAL
Phulen Sarma, Harish Kumar, Bikash Medhi
No abstract text is available yet for this article.
September 2017: Indian Journal of Pharmacology
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