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Indian Journal of Pharmacology

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https://www.readbyqxmd.com/read/28458441/erratum-modulation-of-hippocampal-gene-expression-of-microrna-146a-microrna-155-nuclear-factor-kappa-b-inflammatory-signaling-by-troxerutin-in-healthy-and-diabetic-rats
#1
(no author information available yet)
[This corrects the article on p. 675 in vol. 48, PMID: 28066106.].
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458440/hydroxychloroquine-induced-erythroderma
#2
Sunil B Pai, Bhuvaneshwari Sudershan, Maria Kuruvilla, Ashwin Kamath, Pooja K Suresh
Erythroderma is characterized by diffuse erythema and scaling of the skin involving more than 90% of the total body skin surface area. Drug-induced erythroderma has rarely been reported with hydroxychloroquine. We report a case of a 50-year-old female patient, with systemic lupus erythematosus, who developed itchy lesions all over the body 1 month after starting treatment with hydroxychloroquine. Drug-induced erythroderma was suspected. Hydroxychloroquine was withdrawn and the patient was treated with emollients, mid-potency corticosteroids, and oral antihistamines...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458439/chronic-administration-of-phenytoin-and-pleomorphic-adenoma-a-case-report-and-review-of-literature
#3
Vikas Maharshi, Pravesh Nagar
Adverse drug effects that are uncommon or appear only on chronic administration of a drug may not be detected in clinical trials. This explains the need of strict post-marketing vigilance on drug use. Phenytoin administration has been shown in the literature to be associated with development of neoplasia (benign/malignant). In our knowledge current work represents the first case of pleomorphic-adenoma of sub-mandibular salivary gland developed following chronic phenytoin use. A 40 year old male having a history of head trauma twenty years back, had been on tablet phenytoin 100 mg thrice daily since then...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458438/chronic-lithium-intoxication-varying-electrocardiogram-manifestations
#4
Raja Naga Mahesh Maddala, A J Ashwal, M Sudhakar Rao, R Padmakumar
Lithium is a commonly used drug in psychiatric practice. It is used in the treatment of depression and bipolar disorder. It has a narrow therapeutic index with documented adverse effects even near therapeutic levels. It has myriad of manifestations at toxic levels. The cardiovascular effects range from relatively benign ST-T wave changes to fatal arrhythmias. We describe a case of lithium toxicity which presented as a junctional rhythm and later showed a variety of manifestations such as complete heart block, atrial fibrillation, sinus bradycardia, and finally reverted to sinus rhythm at par with serum lithium levels...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458437/levetiracetam-induced-leukocytoclastic-vasculitis
#5
Mrinal Gupta
Drug-induced leukocytoclastic vasculitis is a small-vessel vasculitis that most commonly manifests with palpable purpuric lesions on gravity-dependent areas. Vasculitis occurs within weeks after initial administration of medication and demonstrates clearance upon withdrawal of medication. Levetiracetam, a pyrrolidone derivative, is used as an adjunctive therapy in patients with refractory focal epilepsy, myoclonic epilepsy, and primary generalized tonic-clonic seizures. We present a case of a 14-year-old female, who developed cutaneous small-vessel vasculitis within 8 days of initiation of levetiracetam...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458436/response-to-eperisone-in-patients-of-therapy-resistant-dissociative-convulsions-a-report-of-two-cases
#6
Vijendra Nath Jha, Pramod Kumar Singh
Dissociative convulsions or pseudoseizures are a difficult to treat common psychiatric condition. In a subset of these patients, the chief complaint is clenching of teeth with apparent nonresponsiveness alone. Neither drugs nor psychotherapeutic interventions have been found to be of much help in its management. Report of two such subsets of cases is presented, in which patients with dissociative convulsions showed sudden, dramatic, and sustained good response to the addition of a muscle relaxant eperisone.
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458435/ciprofloxacin-induced-acute-generallised-exanthematous-pustulosis
#7
Caterina Foti, Paolo Romita, Giovanni Zanframundo, Mario Mastrolonardo, Gianni Angelini, Gianfranco Calogiuri, Eustacchio Nettis, Domenico Bonamonte
Acute generalized exanthematous pustulosis (AGEP) is an uncommon and self-limiting skin rash commonly caused by drugs and is characterized by the acute onset of fever, pustulosis, and neutrophilia from 4 to 10 days after the drug intake. We describe a case of AGEP in a 61-year-old woman that was hospitalized for the acute onset of fever, erythroderma, and pustulosis. Clinical history revealed that she had been treating a bacterial inguinal intertrigo for 4 days with ciprofloxacin 500 mg tablets twice daily and desloratadine 5 mg tablet once daily...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458434/noninvasive-recording-of-electrocardiogram-in-conscious-rat-a-new-device
#8
Pradeep Kumar, Pooja Srivastava, Ankit Gupta, Manish Bajpai
AIM: Electrocardiogram (ECG) is an important tool for the study of cardiac electrophysiology both in human beings and experimental animals. Existing methods of ECG recording in small animals like rat have several limitations and ECG recordings of the anesthetized rat lack validity for heart rate (HR) variability analysis. The aim of the present study was to validate the ECG data from new device with ECG of anesthetized rat. MATERIALS AND METHODS: The ECG was recorded on student's physiograph (BioDevice, Ambala) and suitable coupler and electrodes in six animals first by the newly developed device in conscious state and second in anesthetized state (stabilized technique)...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458433/evaluation-of-relationship-of-inhaler-technique-with-asthma-control-and-quality-of-life
#9
Bharti Chogtu, Sadhana Holla, Rahul Magazine, Asha Kamath
INTRODUCTION: There is a need to assess erroneous steps in the use of inhaler devices in people who have asthma. The objectives of this study were to assess the inhaler technique in patients who have asthma, the factors affecting improper technique, and the association of inhaler use with asthma control, hospital visits, and quality of life (QOL) of patients who have asthma. METHODS: It was an observational, prospective, cross-sectional study conducted on patients with bronchial asthma...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458432/rational-drug-therapy-education-in-clinical-phase-carried-out-by-task-based-learning
#10
S Sırrı Bilge, Bahar Akyüz, Arzu Erdal Ağrı, Mıdık Özlem
OBJECTIVES: Irrational drug use results in drug interactions, treatment noncompliance, and drug resistance. Rational pharmacotherapy education is being implemented in many faculties of medicine. Our aim is to introduce rational pharmacotherapy education by clinicians and to evaluate task-based rational drug therapy education in the clinical context. METHODS: The Kirkpatrick's evaluation model was used for the evaluation of the program. The participants evaluated the program in terms of constituents of the program, utilization, and contribution to learning...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458431/a-pharmacological-evidence-for-the-presence-of-antihistaminic-and-anticholinergic-activities-in-equisetum-debile-roxb
#11
Shahrukh Ali, Muhammad Ovais Omer, Mueen Ahmad Chaudhry, Muhammad Ashraf, Allah Bukhsh
OBJECTIVE: The study was designed to evaluate possible antihistaminic and anticholinergic activities of Equisetum debile. MATERIALS AND METHODS: Effects of crude ethanolic (Ed.Eth) and effects of crude aqueous (Ed.Aq) extracts of E. debile were studied using isolated guinea pig ileum, rabbit jejunum, and rabbit trachea. Tissue responses were recorded using isotonic and isometric transducers, connected with PowerLab data acquisition system. RESULTS: A dose-dependent (0...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458430/anesthetic-efficacy-of-ketamine-diazepam-ketamine-xylazine-and-ketamine-acepromazine-in-caspian-pond-turtles-mauremys-caspica
#12
Milad Adel, Amin Bigham Sadegh, Vincenzo Arizza, Hossein Abbasi, Luigi Inguglia, Hasan Nasrollahzadeh Saravi
OBJECTIVES: The objective of this study was to assess the efficacy of different anesthetic drug combinations on the Caspian Pond turtles (Mauremys caspica). SUBJECTS AND METHODS: Three groups of the Caspian Pond turtles (n = 6) were anesthetized with three different drug combinations. Initially, a pilot study was conducted to determine the best drug doses for the anesthetization of the turtles, and according to these results, ketamine-diazepam (120 mg/kg ketamine hydrochloride [5%] and 2 mg/kg diazepam [5%]), ketamine-acepromazine (120 mg/kg ketamine hydrochloride [5%] and 1 mg/kg acepromazine [1%]), and ketamine-xylazine (120 mg/kg ketamine hydrochloride [5%] and 1 mg/kg xylazine [2%]) were injected intramuscularly...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458429/pricing-and-components-analysis-of-some-key-essential-pediatric-medicine-in-odisha-state
#13
Satyajit Samal, Trupti Rekha Swain
OBJECTIVE: Study highlighting prices, i.e., the patients actually pay at ground level is important for interventions such as alternate procurement schemes or to expedite regulatory assessment of essential medicines for children. The present study was undertaken to study pricing and component analysis of few key essential medicines in Odisha state. METHODOLOGY: Six child-specific medicines of different formulations were selected based on use in different disease condition and having widest pricing variation...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458428/a-study-of-the-use-of-drugs-in-patients-suffering-from-psoriasis-and-their-impact-on-quality-of-life
#14
V V Karamata, A M Gandhi, P P Patel, A Sutaria, M K Desai
OBJECTIVE: To study the use of drugs in patients suffering from psoriasis and their effect on quality of life (QOL). MATERIALS AND METHODS: This was a prospective, observational study carried out in newly diagnosed patient of psoriasis at Department of Pharmacology and Outpatient Department of Skin and Venereal diseases at tertiary care teaching hospital, and patients were divided into three groups: Group A: topical therapy alone, Group B: methotrexate with topical therapy, and Group C: cyclosporine with topical therapy...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458427/antiurolithiatic-and-antioxidant-efficacy-of-musa-paradisiaca-pseudostem-on-ethylene-glycol-induced-nephrolithiasis-in-rat
#15
Padma Nibash Panigrahi, Sahadeb Dey, Monalisa Sahoo, Ananya Dan
OBJECTIVE: Musa paradisiaca has been used in the treatment of urolithiasis by the rural people in South India. Therefore, we plan to evaluate its efficacy and possible mechanism of antiurolithiatic effect to rationalize its medicinal use. MATERIALS AND METHODS: Urolithiasis was induced in hyperoxaluric rat model by giving 0.75% ethylene glycol (EG) for 28 days along with 1% ammonium chloride (AC) for the first 14 days. Antiurolithiatic effect of aqueous-ethanol extract of M...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458426/antidiabetic-antihyperlipidemic-and-antioxidant-activities-of-musa-balbisiana-colla-in-type-1-diabetic-rats
#16
Mukundam Borah, Swarnamoni Das
OBJECTIVES: To evaluate the antidiabetic, antihyperlipidemic, and antioxidant activities of the ethanolic extracts of the flowers and inflorescence stalk of Musa balbisiana Colla. in streptozotocin (STZ)-induced Type 1 diabetic rats. MATERIALS AND METHODS: Diabetes was induced in male Wistar albino rats (150-200 g) by single intraperitoneal injection of STZ (60 mg/kg b.w. i.p.). Albino rats (n = 25) were divided into five groups, of which five animals each. Group A (normal control) and Group B (diabetic control) received normal saline (10 ml/kg/day p...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458425/cardioprotective-effect-of-curcumin-and-piperine-combination-against-cyclophosphamide-induced-cardiotoxicity
#17
Manodeep Chakraborty, Ananya Bhattacharjee, Jagadish Vasudev Kamath
OBJECTIVE: Curcumin is a well-established cardioprotective phytoconstituent, but the poor bioavailability associated with it is always a matter of therapeutic challenge. The present study was undertaken to increase the therapeutic efficacy of curcumin by combining with bio-enhancer like piperine against cyclophosphamide (CP)-induced cardiotoxicity in rats. MATERIALS AND METHODS: Rats (n = 8) were treated with curcumin (200 mg/kg, p.o.) alone and different dose combination of curcumin (100, 50, 25 mg/kg, p...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458424/evaluation-of-neuroprotective-effect-of-quercetin-with-donepezil-in-scopolamine-induced-amnesia-in-rats
#18
Laxmi Adiveppa Pattanashetti, Ashok D Taranalli, Vinay Parvatrao, Rohit H Malabade, Dushyant Kumar
OBJECTIVE: The objective of this study was to evaluate the neuroprotective effect of quercetin with donepezil in scopolamine-induced amnesia in rats. MATERIALS AND METHODS: Five groups of adult male Wistar rats (12 months old) weighing 180-200 g (n = 6) were used. The normal control group received normal saline and test group animals were pretreated orally with quercetin (25 mg/kg), donepezil (3 mg/kg), and a combination of quercetin (25 mg/kg) with donepezil (3 mg/kg), respectively, dosed at every 24 h interval for 14 consecutive days, afterward amnesia was induced by scopolamine (3 mg/kg) on the 14(th) day through intraperitoneal route...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458423/effect-of-angelica-glauca-essential-oil-on-allergic-airway-changes-induced-by-histamine-and-ovalbumin-in-experimental-animals
#19
Shilpa Sharma, Vijaykumar P Rasal, Paragouda A Patil, Rajesh K Joshi
OBJECTIVE: Angelica glauca Edgew (Apiaceae) is used in traditional medicine for treatment of several diseases including bronchial asthma. The present investigation was aimed to evaluate broncho-relaxant activity of A. glauca essential oil in histamine and ovalbumin (OVA)-induced broncho constriction in experimental animals. MATERIALS AND METHODS: Airway was induced using histamine aerosol in guinea pigs (n = 24) and OVA aerosol in albino mice (n = 24). The number of inflammatory cells, namely, absolute eosinophils count in blood, total immunoglobulin E (IgE) in serum, eosinophils, and neutrophils in bronchoalveolar lavage fluid (BALF) and histopathological examination of lung tissues were investigated in A...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458422/effect-of-daidzein-on-cisplatin-induced-hematotoxicity-and-hepatotoxicity-in-experimental-rats
#20
Sanjiv Karale, Jagadish Vasudev Kamath
OBJECTIVE: The objective of the study was to investigate the effect of daidzein flavonoid on cisplatin (CP)-induced hematotoxicity and hepatotoxicity in experimental rats. MATERIALS AND METHODS: The Wistar rats were randomly divided into four equal groups: Normal (saline 1 ml p.o.), CP (7.5 mg/kg once intraperioteneally on 16(th) day), test group of low dose (combination of CP and daidzein 20 mg/kg p.o. for 21 days), and test group of high dose (combination of CP and daidzein 40 mg/kg p...
January 2017: Indian Journal of Pharmacology
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