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Journal of Cancer Research and Clinical Oncology

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https://www.readbyqxmd.com/read/28540403/analysis-of-primary-mirna-3662-and-its-mature-form-may-improve-detection-of-the-lung-adenocarcinoma
#1
Tomasz Powrózek, Radosław Mlak, Marcin Dziedzic, Teresa Małecka-Massalska, Dariusz Sagan
INTRODUCTION: Because of the alarming data concerning lung cancer morbidity and mortality, investigation of new molecular markers allowing early cancer detection is desirable. In the present study, we investigated the potential role of miRNA-3662 precursor (pri-miRNA-3662) as potential novel diagnostic marker of lung adenocarcinoma (AC). MATERIALS AND METHODS: Expression of miRNA-3662 and pri-miRNA-3662 was analyzed in 56 fresh-frozen tissues of non-small cell lung cancer and corresponding adjacent non-cancerous tissues using (NCT) qRT-PCR...
May 24, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28536738/selective-targeted-delivery-of-doxorubicin-via-conjugating-to-anti-cd24-antibody-results-in-enhanced-antitumor-potency-for-hepatocellular-carcinoma-both-in-vitro-and-in-vivo
#2
Zhaoxiong Ma, Hua He, Fumou Sun, Yao Xu, Xuequn Huang, Yuexing Ma, Hong Zhao, Yang Wang, Min Wang, Juan Zhang
PURPOSE: Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for clinical application. Cluster of differentiation 24 (CD24) is over-expressed in several human malignancies, especially in hepatocellular carcinoma (HCC). We aimed to develop a new class of CD24-targeted ADCs for HCC. METHODS: DOX was conjugated with G7mAb by a heterobifunctional cross-linker GMBS (N-[gamma-maleimido butyryloxy] succinimide ester) and further analyzed using HPLC...
May 23, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28534173/successful-treatment-of-patients-with-newly-diagnosed-untreated-light-chain-multiple-myeloma-with-a-combination-of-bendamustine-prednisone-and-bortezomib-bpv
#3
Hannah Tessenow, Madlen Holzvogt, Bruno Holzvogt, Marc Andrea, Simone Heyn, Thomas Schliwa, Maik Schwarz, Thomas Zehrfeld, Cornelia Becker, Christian Pfrepper, Georg Nikolaus Franke, Rainer Krahl, Madlen Jentzsch, Sabine Leiblein, Sebastian Schwind, Marius Bill, Vladan Vucinic, Thoralf Lange, Dietger Niederwieser, Wolfram Pönisch
INTRODUCTION: Patients with light chain myeloma frequently have a light chain tubular cast nephropathy, which can lead to severe renal impairment. In the present retrospective study, bortezomib was combined with other active substances like bendamustine and prednisone (BPV), in order to assess the efficacy and toxicity of the combination therapy in patients with light chain multiple myeloma. METHODS: Between September 2008 and May 2015, 25 patients with newly diagnosed light chain multiple myeloma were treated with bendamustine 60 mg/m(2) on days 1 and 2, bortezomib 1...
May 22, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28534172/the-influence-of-local-therapy-on-the-survival-of-patients-with-metastatic-rectal-cancer-a-population-based-propensity-matched-study
#4
Chi-Hao Zhang, Yuan-Bo Pan, Qing-Wei Zhang, Ou-Min Shi, Lei Zheng, Liang Gui, Meng Luo
PURPOSE: This study was aimed to determine the effect of the local tumor therapy on patients' prognosis in the management of metastatic rectal cancer. METHODS: Patients diagnosed with metastatic rectal cancer from 2004 to 2013 were selected from the SEER (Surveillance, Epidemiology, and End Results) database. Overall survival and cancer-specific survival were compared between the local treatment group and the nonlocal treatment group using Kaplan-Meier methods. Uni- and multivariate analyses were further performed to confirm or deny the results...
May 22, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28534171/surgery-for-colorectal-cancer-in-elderly-patients-how-can-we-improve-outcome
#5
Henning Mothes, Astrid Bauschke, Silke Schuele, Ekkehard Eigendorff, Annelore Altendorf-Hofmann, Utz Settmacher
PURPOSE: Patients over 70 years of age are characterised by diminished long-term survival rates following resection of colorectal cancer (CRC) compared to younger patients. The aim of this study was to clarify whether reduced survival is a result of malignancy, comorbidities or the treatment received. METHODS: All patients with CRC, who were admitted to our institution over a period of 10 years, were selected from a prospectively maintained database. Disease-specific, disease-free and overall survival rates were calculated dependent on variables considered potentially relevant for the patients' prognosis...
May 22, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28528497/microrna-30a-5p-mir-30a-regulates-cell-motility-and-emt-by-directly-targeting-oncogenic-tm4sf1-in-colorectal-cancer
#6
Y R Park, S L Kim, M R Lee, S Y Seo, J H Lee, S H Kim, I H Kim, S O Lee, S T Lee, Sang Wook Kim
PURPOSE: Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide, and many oncogenes and tumor suppressor genes are involved in CRC. MicroRNAs (miRNAs) are small non-coding RNAs that can negatively regulate gene expression. Previous studies have revealed that miRNAs regulate the development and progression of many cancers. In this study, we investigated the role of microRNA-30a-5p (miR-30a) in CRC and its unknown mechanisms. METHODS: qRT-PCR was used to detect miR-30a and TM4SF1 mRNA expression in CRC specimens and cell lines...
May 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28523407/heterogeneous-oncologic-outcomes-according-to-surgical-pathology-in-high-risk-prostate-cancer-implications-for-better-risk-stratification-and-preoperative-prediction-of-oncologic-outcomes
#7
Seung-Kwon Choi, Myungsun Shim, Myong Kim, Myungchan Park, Sangmi Lee, Cheryn Song, Hyung-Lae Lee, Hanjong Ahn
PURPOSE: To evaluate the better risk stratification based on surgical pathology, and to predict oncologic outcomes after radical prostatectomy (RP) with a better scoring system in high-risk prostate cancer (PCa) patients. METHODS: We evaluated high-risk PCa patients (PSA >20 ng/ml, ≥cT3a, or Gleason score 8-10) who underwent RP between 2007 and 2013 at our institute. We classified patients into three groups according to their pathologic outcomes: favorable (pT2, Gleason score ≤7, and node negative), intermediate (specimen-confined disease (pT2-3a, node negative PCa with negative surgical margins) but not in the favorable group), and unfavorable (the remaining patients)...
May 18, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28516380/polymyalgia-rheumatica-in-a-melanoma-patient-due-to-nivolumab-treatment
#8
LETTER
Kiyotaka Nakamagoe, Tetuya Moriyama, Hiroshi Maruyama, Masahiro Yokosawa, Tadashi Hara, Shinya Tanaka, Manabu Fujimoto, Akira Tamaoka
No abstract text is available yet for this article.
May 17, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28497169/homogeneous-pancreatic-cancer-spheroids-mimic-growth-pattern-of-circulating-tumor-cell-clusters-and-macrometastases-displaying-heterogeneity-and-crater-like-structure-on-inner-layer
#9
Hao Feng, Bao-Chi Ou, Jing-Kun Zhao, Shuai Yin, Ai-Guo Lu, Eva Oechsle, Wolfgang E Thasler
PURPOSE: Pancreatic cancer 3D in vitro models including multicellular tumor spheroid (MCTS), single cell-derived tumor spheroid (SCTS), tissue-derived tumor spheroid, and organotypic models provided powerful platforms to mimic in vivo tumor. Recent work supports that circulating tumor cell (CTC) clusters are more efficient in metastasis seeding than single CTCs. The purpose of this study is to establish 3D culture models which can mimic single CTC, monoclonal CTC clusters, and the expansion of macrometastases...
May 11, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28493019/surgical-treatment-of-advanced-penile-cancer
#10
Ke Zhang, Xiang Wan, Huan Xu, Wenzhi Li, Juan Zhou, Ming-Xi Xu, Hai-Jun Yao, Zhong Wang
PURPOSE: To evaluate the therapeutic effect of surgery in patients with advanced penile cancer, who have a dismal prognosis. PATIENTS AND METHODS: Between September 2007 and July 2015, we treated 12 patients with surgical therapy. RESULTS: The median follow-up period for all the patients was 16 months (range 4-60 months). The outcome and concomitant symptoms were analyzed, and the survival rates were calculated. Three of the patients are currently alive...
May 10, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28484844/urinary-transcript-quantitation-of-ck20-and-igf2-for-the-non-invasive-bladder-cancer-detection
#11
Karsten Salomo, Doreen Huebner, Manja U Boehme, Alexander Herr, Werner Brabetz, Ulrike Heberling, Oliver W Hakenberg, Daniela Jahn, Marc-Oliver Grimm, Daniel Steinbach, Marcus Horstmann, Michael Froehner, Manfred P Wirth, Susanne Fuessel
PURPOSE: Cytokeratin 20 (CK20) and insulin-like growth factor 2 (IGF2) were previously proposed to be elevated in clinical samples from patients with bladder cancer (BCa). A two cohort design validation study was used to assess the relevance for BCa detection by transcript quantitation of both markers in urine samples. Their diagnostic value was assessed in comparison with voided urine cytology (VUC). METHODS: RNA isolation was carried out using cellular sediments of urine samples from 196/103 histologically positive BCa patients, as well as 97/50 control subjects for the test (TC) and validation cohort (VC), respectively...
May 8, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28470473/reduced-intensity-conditioning-of-allogeneic-hematopoietic-stem-cell-transplantation-for-myelodysplastic-syndrome-and-acute-myeloid-leukemia-in-patients-older-than-50%C3%A2-years-of-age-a-systematic-review-and-meta-analysis
#12
Zhi-Hui Zhang, Xin-Yue Lian, Dong-Ming Yao, Pin-Fang He, Ji-Chun Ma, Zi-Jun Xu, Hong Guo, Wei Zhang, Jiang Lin, Jun Qian
PURPOSE: A systematic review and meta-analysis were performed to explore the efficacy and safety of allogeneic hematopoietic stem cell transplantation with a reduced intensity conditioning regimen in elderly patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). METHODS: Overall survival (OS) and event-free survival (EFS) were established as the primary endpoints for directly assessing the efficacy, and non-relapse mortality (NRM) for safety...
May 3, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28470472/impact-of-intra-tumoral-il17a-and-il32-gene-expression-on-t-cell-responses-and-lymph-node-status-in-breast-cancer-patients
#13
Shreyas Bhat, Nilesh Gardi, Sujata Hake, Nirupama Kotian, Sharada Sawant, Sadhana Kannan, Vani Parmar, Sangeeta Desai, Amit Dutt, Narendra N Joshi
PURPOSE: Pro-inflammatory cytokines such as Interleukin-17A (IL17A) and Interleukin-32 (IL32), known to enhance natural killer and T cell responses, are also elevated in human malignancies and linked to poor clinical outcomes. To address this paradox, we evaluated relation between IL17A and IL32 expression and other inflammation- and T cell response-associated genes in breast tumors. METHODS: TaqMan-based gene expression analysis was carried out in seventy-eight breast tumors...
May 3, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28451753/histologic-subtype-needs-to-be-considered-after-partial-nephrectomy-in-patients-with-pathologic-t1a-renal-cell-carcinoma-papillary-vs-clear-cell-renal-cell-carcinoma
#14
Sangjun Yoo, Dalsan You, In Gab Jeong, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
PURPOSE: We compared the oncological outcomes of papillary renal cell carcinoma (pRCC) with clear cell renal cell carcinoma (ccRCC) after partial nephrectomy (PN) in patients with pathologic T1a RCC. METHODS: After excluding patients with synchronous multiple renal tumors, familial RCC, and pathologic stage T1b or above, 759 patients with ccRCC and 84 patients with pRCC were included. We assessed the impact of histologic subtypes on oncologic outcomes after PN in patients with pathologic T1a RCC (median follow-up duration, 67 months)...
April 27, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28447160/cancer-of-the-ovary-fallopian-tube-and-peritoneum-a-population-based-comparison-of-the-prognostic-factors-and-outcomes
#15
Miriam Rottmann, A Burges, S Mahner, C Anthuber, T Beck, D Grab, A Schnelzer, M Kiechle, D Mayr, M Pölcher, G Schubert-Fritschle, J Engel
PURPOSE: The objective was to compare the prognostic factors and outcomes among primary ovarian cancer (OC), fallopian tube cancer (FC), and peritoneal cancer (PC) patients in a population-based setting. METHODS: We analysed 5399 OC, 327 FC, and 416 PC patients diagnosed between 1998 and 2014 in the catchment area of the Munich Cancer Registry (meanwhile 4.8 million inhabitants). Tumour site differences were examined by comparing prognostic factors, treatments, the time to progression, and survival...
April 26, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28439713/personalized-axillary-dissection-the-number-of-excised-lymph-nodes-of-nodal-positive-breast-cancer-patients-has-no-significant-impact-on-relapse-free-and-overall-survival
#16
Florian Ebner, Achim Wöckel, Wolfgang Janni, Rolf Kreienberg, Lukas Schwentner, Manfred Wischnewsky
PURPOSE: Sentinel lymph node (SLN) biopsy has replaced axillary lymph node dissection (ALND) for the staging of clinically node-negative breast cancer patients (BCP), demonstrating equivalent survival to ALND while resulting in reduced morbidity. ALND has remained the standard of care for the majority of BCP with clinical axillary metastases or metastases found on SLN biopsy. More recently, it is debated whether ALND could be avoided not only in SLN-negative BCP but also in selected SLN-positive disease or even in all patients...
April 24, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28434043/early-whole-brain-radiotherapy-in-primary-cns-lymphoma-negative-impact-on-quality-of-life-in-the-randomized-g-pcnsl-sg1-trial
#17
Ulrich Herrlinger, Niklas Schäfer, Rolf Fimmers, Frank Griesinger, Michael Rauch, Heinz Kirchen, Patrick Roth, Martin Glas, Michael Bamberg, Peter Martus, Eckhard Thiel, Agnieszka Korfel, Michael Weller
PURPOSE: In the randomized G-PCNSL-SG-1 trial, the addition of whole brain radiotherapy (45 Gy) to high-dose methotrexate (HD-MTX)-based chemotherapy (early WBRT arm) did not prolong overall survival (OS) as compared to HD-MTX-based chemotherapy alone (no early WBRT arm) in primary CNS lymphoma (PCNSL) patients. To determine whether WBRT might lead to quality of life (QoL)-relevant late neurotoxicity, this trial prospectively monitored QoL. METHODS: QoL measurements were performed using the EORTC-QLQ-C30 and BN20 questionnaires and combined with repeated Mini Mental State Examinations (MMSE)...
April 22, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28434042/erratum-to-curcumin-induces-g2-m-arrest-apoptosis-nf-%C3%AE%C2%BAb-inhibition-and-expression-of-differentiation-genes-in-thyroid-carcinoma-cells
#18
Suzan Schwertheim, Frederik Wein, Klaus Lennartz, Karl Worm, Kurt Werner Schmid, Sien-Yi Sheu-Grabellus
No abstract text is available yet for this article.
April 22, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28432456/deregulated-bcl-2-family-proteins-impact-on-repair-of-dna-double-strand-breaks-and-are-targets-to-overcome-radioresistance-in-lung-cancer
#19
Sarah A Wieczorek, Frank Breitenbuecher, Aashish Soni, Katja Paul-Konietzko, Sophie Ziegler, Ali Sak, George Iliakis, Martin Schuler
PURPOSE: DNA damage-induced cell death is a major effector mechanism of radiotherapy. Aberrant expression of anti-apoptotic BCL-2 family proteins is frequently observed in lung cancers. Against this background, we studied radioresistance mediated by BCL-2 family proteins at the mechanistic level and its potential as target for radiochemotherapy. METHODS: Lung cancer models stably expressing BCL-xL or MCL-1 were irradiated to study cell death, clonogenic survival, and DNA repair kinetics in vitro, and growth suppression of established tumors in vivo...
April 21, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28432455/dual-activation-of-toll-like-receptors-7-and-9-impairs-the-efficacy-of-antitumor-vaccines-in-murine-models-of-metastatic-breast-cancer
#20
Mariela A Moreno Ayala, María Florencia Gottardo, María Soledad Gori, Alejandro Javier Nicola Candia, Carla Caruso, Andrea De Laurentiis, Mercedes Imsen, Slobodanka Klein, Elisa Bal de Kier Joffé, Gabriela Salamone, Maria G Castro, Adriana Seilicovich, Marianela Candolfi
PURPOSE: Since combination of Toll-like receptor (TLR) ligands could boost antitumor immunity, we evaluated the efficacy of dendritic cell (DC) vaccines upon dual activation of TLR9 and TLR7 in breast cancer models. METHODS: DCs were generated from mouse bone marrow or peripheral blood from healthy human donors and stimulated with CpG1826 (mouse TLR9 agonist), CpG2006 or IMT504 (human TLR9 agonists) and R848 (TLR7 agonist). Efficacy of antitumor vaccines was evaluated in BALB/c mice bearing metastatic mammary adenocarcinomas...
April 21, 2017: Journal of Cancer Research and Clinical Oncology
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