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Journal of Cancer Research and Clinical Oncology

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https://www.readbyqxmd.com/read/28653099/meeting-report-of-the-6th-heidelberg-myeloma-workshop-current-status-and-developments-in-diagnosis-and-therapy-of-multiple-myeloma
#1
Maximilian Merz, Marc S Raab, Hartmut Goldschmidt, Jens Hillengass
PURPOSE: The 6th Heidelberg Myeloma Workshop was held on May 5th and 6th, 2017 in the lecture hall of the University Hospital Heidelberg. METHODS AND RESULTS: Main topics of the meeting were (1) biology and genomics of multiple myeloma, (2) diagnostics and prognostic factors, (3) role of immunotherapy in multiple myeloma, as well as (4) therapy of multiple myeloma-drugs and treatment strategies. CONCLUSION: The landscape for the treatment of newly diagnosed and relapsed disease has significantly changed since the last Heidelberg Myeloma Workshop in 2015...
June 26, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28653098/overexpression-of-glutathione-peroxidase-1-predicts-poor-prognosis-in-oral-squamous-cell-carcinoma
#2
Jae Ryung Lee, Jong-Lyel Roh, Sun Mi Lee, Yangsoon Park, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
PURPOSE: Intracellular antioxidant enzymes are commonly upregulated in various cancer types and are associated with treatment outcomes. Because the relationship has rarely been examined in oral squamous cell carcinoma (OSCC), we aimed to evaluate the association between the levels of glutathione peroxidase (GPX)1, GPX4, and thioredoxin reductase (TrxR)1 expression and prognosis in patients with OSCC who underwent curative surgical resection. METHODS: This study included 233 patients who underwent curative surgery for previously untreated OSCC between 2000 and 2012...
June 26, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28647857/ros-modulated-therapeutic-approaches-in-cancer-treatment
#3
REVIEW
Muhammad Hassan Raza, Sami Siraj, Abida Arshad, Usman Waheed, Fahad Aldakheel, Shatha Alduraywish, Muhammad Arshad
PURPOSE: Reactive oxygen species (ROS) are produced in cancer cells as a result of increased metabolic rate, dysfunction of mitochondria, elevated cell signaling, expression of oncogenes and increased peroxisome activities. Certain level of ROS is required by cancer cells, above or below which lead to cytotoxicity in cancer cells. This biochemical aspect can be exploited to develop novel therapeutic agents to preferentially and selectively target cancer cells. METHODS: We searched various electronic databases including PubMed, Web of Science, and Google Scholar for peer-reviewed english-language articles...
June 24, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28646261/hepatic-arterial-infusion-chemotherapy-for-extensive-liver-metastases-of-breast-cancer-efficacy-safety-and-prognostic-parameters
#4
Mitra Tewes, Michael Wilhelm Peis, Simon Bogner, Jens M Theysohn, Marcus Paul Reinboldt, Martin Schuler, Anja Welt
PURPOSE: Hepatic arterial infusion chemotherapy (HAIC) is an option for patients with liver-predominant metastatic breast cancer (LMBC), when no further systemic treatment is available. But systematic reports are limited. Here we conducted a retrospective analysis of LMBC patients treated at an expert center. METHODS: Individual patient data were retrieved from the clinical data base of the West German Cancer Center. Primary endpoints included hepatic response (RECIST), progression-free survival (PFS), overall survival (OS), and toxicity...
June 23, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28639083/tumor-vascularization-and-clinicopathologic-parameters-as-prognostic-factors-in-merkel-cell-carcinoma
#5
A Bob, F Nielen, J Krediet, J Schmitter, D Freundt, D Terhorst, J Röwert-Huber, J Kanitakis, E Stockfleth, Ch Ulrich, M Weichenthal, F Egberts, B Lange-Asschenfeldt
PURPOSE: Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine tumor of the skin with an increasing incidence. The clinical course is variable and reliable prognostic factors are scarce. Tumor angiogenesis has been shown to have prognostic impact in different types of cancer. The aim of our study was to determine potential prognostic factors, including tumor vascularization, for clinical outcome of MCC. METHODS: The medical records of 46 patients with MCC diagnosed between 1997 and 2010 were analyzed retrospectively...
June 21, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28634728/aroma-oil-therapy-in-palliative-care-a-pilot-study-with-physiological-parameters-in-conscious-as-well-as-unconscious-patients
#6
Melanie Goepfert, Patrick Liebl, Natalie Herth, Giancarlo Ciarlo, Jens Buentzel, Jutta Huebner
OBJECTIVE: The aim of this pilot study is to analyze the reactions of healthy test persons and conscious as well as unconscious palliative patients to aroma stimuli. PATIENTS AND METHODS: In a randomized controlled study, healthy probands, conscious and unconscious palliative patients were exposed to two essential oils (lemon, lavender). Water was used as the control stimulus. Physiological parameters (breathing rate and heart rate, oxygen saturation, systolic, diastolic and mean arterial pressure) were measured...
June 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28634727/safety-and-efficacy-of-chemosaturation-in-patients-with-primary-and-secondary-liver-tumors
#7
Martha M Kirstein, Steffen Marquardt, Nils Jedicke, Silke Marhenke, Wolfgang Koppert, Michael P Manns, Frank Wacker, Arndt Vogel
BACKGROUND: Chemosaturation with percutaneous hepatic perfusion (CS-PHP; hepatic CHEMOSAT(®) delivery system; Delcath Systems Inc, USA) is a novel medical device, which delivers high doses of melphalan directly to the liver in patients with primary and secondary liver tumors while limiting systemic toxicity through hemofiltration of the hepatic venous blood. The aim of this study was to analyze the safety and efficacy of the second-generation CS-PHP after 54 treatments at Hannover Medical School, Germany...
June 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28631213/the-constitutive-protease-release-by-primary-human-acute-myeloid-leukemia-cells
#8
Maria Honnemyr, Øystein Bruserud, Annette K Brenner
INTRODUCTION: Acute myeloid leukemia (AML) cells show constitutive release of matrix metalloproteases and their inhibitors. We now investigated this constitutive release of protease/protease regulators associated with carcinogenesis (ADAM12, uPA, cystatin B), angiogenesis (serpin E1, uPA, CD147), cancer cell migration (uPA, cystatin C), coagulation (ADAM TS13, serpin C1), inflammation (fetuin A, caspase 1, cystatin C), monocytic differentiation (CFD) or regulation of hematopoiesis (neutrophil elastase)...
June 19, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28624910/clinical-pharmacology-and-clinical-trials-of-ribonucleotide-reductase-inhibitors-is-it-a-viable-cancer-therapy
#9
REVIEW
Mukundan Baskar Mannargudi, Subrata Deb
PURPOSE: Ribonucleotide reductase (RR) enzymes (RR1 and RR2) play an important role in the reduction of ribonucleotides to deoxyribonucleotides which is involved in DNA replication and repair. Augmented RR activity has been ascribed to uncontrolled cell growth and tumorigenic transformation. METHODS: This review mainly focuses on several biological and chemical RR inhibitors (e.g., siRNA, GTI-2040, GTI-2501, triapine, gemcitabine, and clofarabine) that have been evaluated in clinical trials with promising anticancer activity from 1960's till 2016...
June 17, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28623481/erratum-to-homogeneous-pancreatic-cancer-spheroids-mimic-growth-pattern-of-circulating-tumor-cell-clusters-and-macrometastases-displaying-heterogeneity-and-crater-like-structure-on-inner-layer
#10
Hao Feng, Bao-Chi Ou, Jing-Kun Zhao, Shuai Yin, Eva Oechsle, Ai-Guo Lu
No abstract text is available yet for this article.
June 16, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28620685/the-efficacy-of-a-new-high-intensity-focused-ultrasound-therapy-for-locally-advanced-pancreatic-cancer
#11
Jing Zhao, Fuguang Zhao, Yulan Shi, Yongchuan Deng, Xiaoye Hu, Hong Shen
PURPOSE: To compare the survival benefit and safety of the low power cumulative and traditional high intensity focused ultrasound (HIFU) for locally advanced pancreatic cancer. METHOD: We retrospectively analyzed 38 patients with locally advanced, inoperable, stage III pancreatic patients received HIFU treatment between January 2008 and April 2014 in the Department of Surgery, the Second Affiliated Hospital, Zhejiang University, School of Medicine. 11 of them received the low power cumulative HIFU treatment, while other 27 received the traditional HIFU treatment...
June 15, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28620684/response-to-men-and-women-show-similar-survival-rates-after-breast-cancer-yin-pan-ze-zhou-song
#12
LETTER
Luiz Claudio Santos Thuler, Anke Bergmann, Paulo Franscisco Mascarenhas Bender, Letícia Lima de Oliveira, Célia Regina Costa, Suzana Sales de Aguiar
No abstract text is available yet for this article.
June 15, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28616702/the-indication-of-completion-lobectomy-for-lung-adenocarcinoma-%C3%A2-3%C3%A2-cm-after-wedge-resection-during-surgical-operation
#13
Yiyang Wang, Rui Wang, Difan Zheng, Baohui Han, Jie Zhang, Heng Zhao, Jizhuang Luo, Jiajie Zheng, Tianxiang Chen, Qingyuan Huang, Yihua Sun, Haiquan Chen
PURPOSE: This retrospective study was designed to find out the potential indications of completion lobectomy (CL) during wedge resection (WR) operation among patients with lung adenocarcinoma (ADC) ≤3 cm, by the use of Shanghai Chest Hospital Lung Cancer Database. PATIENTS AND METHODS: There were totally 1938 patients in this study, including 746 WRs and 1192 CLs. The propensity score matching (PSM) was performed to minimize the effect of confounders. Univariable and multivariable cox regressions were analyzed to discover the independent risk factors of recurrence-free survival (RFS) and overall survival (OS)...
June 14, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28616701/predictive-value-of-pd-l1-based-on-mrna-level-in-the-treatment-of-stage-iv-melanoma-with-ipilimumab
#14
C Brüggemann, M C Kirchberger, S M Goldinger, B Weide, A Konrad, M Erdmann, D Schadendorf, R S Croner, L Krähenbühl, K C Kähler, C Hafner, W Leisgang, F Kiesewetter, R Dummer, G Schuler, M Stürzl, L Heinzerling
INTRODUCTION: PD-L1 is established as a predictive marker for therapy of non-small cell lung cancer with pembrolizumab. Furthermore, PD-L1 positive melanoma has shown more favorable outcomes when treated with anti-PD1 antibodies and dacarbazine compared to PD-L1 negative melanoma. However, the role of PD-L1 expression with regard to response to checkpoint inhibition with anti-CTLA-4 is not clear, yet. In addition, the lack of standardization in the immunohistochemical assessment of PD-L1 makes the comparison of results difficult...
June 14, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28608286/survival-of-melanoma-patients-treated-with-novel-drugs-retrospective-analysis-of-real-world-data
#15
Marta Polkowska, Paweł Ekk-Cierniakowski, Edyta Czepielewska, Wojciech Wysoczański, Wojciech Matusewicz, Małgorzata Kozłowska-Wojciechowska
PURPOSE: Recently, several new drugs have been licensed for advanced melanoma therapy, significantly changing the therapeutic landscape. Ipilimumab and vemurafenib were the first drugs that demonstrated a survival benefit over the long-standing standard therapy with dacarbazine. However, the comparative efficacy of these novel drugs has not been properly assessed yet. PATIENTS AND METHODS: We conducted a retrospective analysis of all the Polish population treated between January 2012 and October 2016 with one of the following agents: ipilimumab (IPI), vemurafenib (VEM), dabrafenib (DAB), and classic chemotherapy (CTH)...
June 12, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28601935/a-novel-systemic-immune-inflammation-index-predicts-survival-and-quality-of-life-of-patients-after-curative-resection-for-esophageal-squamous-cell-carcinoma
#16
Lu Wang, Cong Wang, Jiangfeng Wang, Xiaochen Huang, Yufeng Cheng
PURPOSE: A novel systemic immune-inflammation index (SII) based on platelet (P), neutrophil (N), and lymphocyte (L) counts has been reported to be associated with clinical outcomes in several solid tumors. We aimed to investigate its prognostic value in esophageal squamous cell carcinoma (ESCC) and the potential relationship with quality of life (QOL). METHODS: A total of 280 ESCC patients who underwent esophagectomy were enrolled. SII (SII = P × N/L) was calculated on the basis of data obtained within 1 week before surgery...
June 10, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28597099/commentary-on-men-and-women-show-similar-survival-rates-after-breast-cancer
#17
LETTER
Yin Pan, Ze-Zhou Song
No abstract text is available yet for this article.
June 8, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28555356/the-long-term-prognostic-value-of-survivin-expressing-circulating-tumor-cells-in-patients-with-high-risk-non-muscle-invasive-bladder-cancer-nmibc
#18
Chiara Nicolazzo, Gian Maria Busetto, Francesco Del Giudice, Isabella Sperduti, Diana Giannarelli, Angela Gradilone, Paola Gazzaniga, Ettore de Berardinis, Cristina Raimondi
OBJECTIVES: Long-term follow-up study to evaluate the impact on disease-free survival and cancer-specific survival of survivin expression in tissue and CTCs from T1G3 bladder cancer patients. PATIENTS AND METHODS: The study was conducted using tumor tissue and blood samples from 54 patients with a primary diagnosis of T1G3 NMIBC. Survivin was evaluated by reverse transcription-polymerase chain reaction in tumor tissues. CTCs were isolated from blood by CELLection™ Dynabeads (Invitrogen, Carlsbad, CA, USA)...
May 29, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28551769/clinical-course-and-end-of-life-care-in-patients-who-have-died-after-allogeneic-stem-cell-transplantation
#19
Christoph Busemann, Andreas Jülich, Britta Buchhold, Vanessa Schmidt, Laila Schneidewind, Daniel Pink, Christian Andreas Schmidt, Thomas Neumann, William H Krüger
PURPOSE: Allogeneic stem cell transplantation may cure approximately 50% of patients, however, a significant part of the other half might benefit from a high-quality palliative care medicine at the end of life. Somatic, psychic and spiritual needs of these patients may differ from those of patients suffering from incurable solid tumours and are not comprehensively evaluated so far. METHODS: To address this question, data from charts of 123 patients who have died after allogeneic stem cell transplantation were extracted...
May 27, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28551768/an-analysis-of-the-kinetics-of-molecular-response-during-the-first-trimester-of-treatment-with-nilotinib-in-newly-diagnosed-chronic-myeloid-leukemia-patients-in-chronic-phase
#20
Juan Luis Steegmann, Dolors Colomer, Maria-Teresa Gómez-Casares, Valentín García-Gutiérrez, Guillermo Ortí, Angel Ramírez-Payer, Eduardo Olavarria, Ferrán Vall-Llovera, Pilar Giraldo, Eulogio Conde, Rolando Vallansot, Jose Luis López-Lorenzo, Luis Palomera, Alberto Álvarez-Larrán, Venancio Conesa, Guiomar Bautista, Laura Casas, Frank Giles, Andreas Hochhaus, Luis Felipe Casado-Montero
PURPOSE: This study was aimed to analyze the association of very early molecular response to nilotinib with the achievement of deep molecular response (MR4) at 18 months. We hypothesized that the BCR-ABL1 levels during the first 3 months of therapy, and the kinetics of their descent in this period, could be predictive of deep molecular response thereafter. METHODS: This substudy of the ENEST1st trial included 60 patients with chronic myeloid leukemia in chronic phase treated with front-line nilotinib, and BCR-ABL1IS levels were measured using GUS as the control gene...
May 27, 2017: Journal of Cancer Research and Clinical Oncology
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