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Journal of Cancer Research and Clinical Oncology

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https://www.readbyqxmd.com/read/28913558/only-setbp1-hotspot-mutations-are-associated-with-refractory-disease-in-myeloid-malignancies
#1
Nils Winkelmann, Vivien Schäfer, Jenny Rinke, Alexander Kaiser, Philipp Ernst, Sebastian Scholl, Andreas Hochhaus, Thomas Ernst
INTRODUCTION: SETBP1 mutations have been established as a diagnostic marker in myeloid malignancies and are associated with inferior survival. Since there is limited data on their clinical impact and stability during disease progression, we sought to investigate the relationship between SETBP1 mutations and disease evolution. METHODS: Bidirectional Sanger sequencing of the SETBP1 gene was performed for 442 unselected patients with World Health Organization (WHO) defined myeloid disorders...
September 14, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28905168/the-usefulness-of-testosterone-administration-in-identifying-false-positive-elevation-of-serum-human-chorionic-gonadotropin-in-patients-with-germ-cell-tumor
#2
Akitoshi Takizawa, Koji Kawai, Takashi Kawahara, Takahiro Kojima, Satoru Maruyama, Nobuo Shinohara, Shusuke Akamatsu, Tomomi Kamba, Terukazu Nakamura, Osamu Ukimura, Ryosuke Jikuya, Takeshi Kishida, Kenichi Kakimoto, Kazuo Nishimura, Toru Harabayashi, Satoshi Nagamori, Shinichi Yamashita, Yoichi Arai, Yoshitomo Sawada, Noritoshi Sekido, Hidefumi Kinoshita, Tadashi Matsuda, Tohru Nakagawa, Yukio Homma, Hiroyuki Nishiyama
OBJECTIVE: The pituitary production of human chorionic gonadotropin (hCG) can cause false-positive results during or after germ cell tumor (GCT) treatment. Because hypogonadism leads to pituitary hCG production, testosterone administration test (TAT) has been recommended for pituitary hCG diagnosis. However, little is known about its efficacy for the discrimination of pituitary hCG as detected by currently used hCG assays in treatment of GCT. We conducted a retrospective multicenter study to determine the usefulness of TAT...
September 13, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28894944/higher-out-of-pocket-expenses-for-tyrosine-kinase-inhibitor-therapy-is-associated-with-worse-health-related-quality-of-life-in-persons-with-chronic-myeloid-leukemia
#3
Qian Jiang, Haibo Wang, Lu Yu, Robert Peter Gale
PURPOSE: To explore health-related quality-of-life (HRQoL) profiles and identify socio-demographic and clinical variables associated with HRQoL in persons with chronic myeloid leukemia (CML) receiving tyrosine kinase inhibitors (TKIs). METHODS: A cross-sectional questionnaire was distributed to adults with chronic-phase CML receiving tyrosine kinase-inhibitor (TKI) therapy >3 months in complete cytogenetic response (CCyR). Respondents were anonymous. SF-36 Health Survey was used to measure HRQoL...
September 11, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28889189/prognostic-role-of-progesterone-receptor-expression-in-a-population-based-analysis
#4
Adele Caldarella, Alessandro Barchielli
PURPOSE: The role of progesterone (PR) expression in the management of breast cancer is controversial. The aim of this study is to evaluate the characteristics and prognosis of progesterone status among breast cancers patients in a population-based analysis. MATERIALS AND METHODS: Through the Tuscan Cancer Registry data on all the invasive breast cancer cases diagnosed during the period 2004-2005 in the provinces of Florence and Prato, central Italy, were retrieved...
September 9, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28875407/karyopherin-%C3%AE-2-is-a-reliable-marker-for-identification-of-patients-with-high-risk-stage-ii-colorectal-cancer
#5
Dongjun Jeong, Hyeongjoo Kim, Seona Ban, Seunghyun Oh, Sanghee Ji, Doyeon Kim, Tae Sung Ahn, Han Jo Kim, Sang Byung Bae, Hyog Young Kwon, Jungkyun Im, Moon Soo Lee, Hyun Deuk Cho, Chang-Jin Kim, Moo-Jun Baek
PURPOSE: Adjuvant chemotherapy (AC) is frequently considered in patients with high-risk stage II colorectal cancer (CRC). Among patients with stage II CRC who do not receive AC because they are not considered to be at high risk, 20-25% will develop recurrence and die from the disease. Elevated levels of KPNA2 have been observed in various cancers, and overexpression of KPNA2 is related to CRC progression. METHODS: We examined the expression of KPNA2 using 293 CRC tissues, including 118 with stage II CRC, and investigated the applicability of KPNA2 as a biomarker to predict high-risk stage II CRC...
September 5, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28875356/response-to-commentary-on-undertreatment-trend-in-elderly-lung-cancer-patients-in-brazil-jing-lan-tang-chun-jie-hou
#6
LETTER
Luiz Claudio Santos Thuler, Guilherme Jorge Costa, Maria Júlia Gonçalves de Mello, Carlos Gil Ferreira
No abstract text is available yet for this article.
September 5, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28875225/methodological-quality-evaluation-of-systematic-reviews-or-meta-analyses-on-ercc1-in-non-small-cell-lung-cancer-a-systematic-review
#7
REVIEW
Huan Tao, Yueyuan Zhang, Qian Li, Jin Chen
PURPOSES: To assess the methodological quality of systematic reviews (SRs) or meta-analysis concerning the predictive value of ERCC1 in platinum chemotherapy of non-small cell lung cancer. METHODS: We searched the PubMed, EMbase, Cochrane library, international prospective register of systematic reviews, Chinese BioMedical Literature Database, China National Knowledge Infrastructure, Wan Fang and VIP database for SRs or meta-analysis. The methodological quality of included literatures was evaluated by risk of bias in systematic review (ROBIS) scale...
September 5, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28871458/percutaneous-irreversible-electroporation-combined-with-allogeneic-natural-killer-cell-immunotherapy-for-patients-with-unresectable-stage-iii-iv-pancreatic-cancer-a-promising-treatment
#8
Mao Lin, Shuzhen Liang, Xiaohua Wang, Yinqing Liang, Mingjie Zhang, Jibing Chen, Lizhi Niu, Kecheng Xu
PURPOSE: This study was attempted to investigate the safety and clinical efficacy of percutaneous irreversible electroporation combined with allogeneic natural killer cell therapy for treating stage III/IV pancreatic cancer, evaluate median progression-free survival (PFS), and overall survival (OS). METHODS: Between March 2016 and February 2017, we enrolled 67 patients who met the enrollment criteria. According to the latest NCCN Guidelines, the patients were divided into stage III (35 patients, 16 patients received only irreversible electroporation (IRE) and 19 patients received IRE-NK: 8 patients underwent one course NK and 11 patients underwent ≥3 courses) and stage IV (32 patients, 14 patients received only IRE and 18 patients received IRE-NK: 8 patients underwent one course NK and 10 patients underwent ≥3 courses)...
September 4, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28866839/image-guided-ablations-in-patients-with-thyroid-tumors
#9
LETTER
Valerio Ferrara, Ciriaco Buonomenna, Giovanni Mauri
No abstract text is available yet for this article.
September 2, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28852875/commentary-on-undertreatment-trend-in-elderly-lung-cancer-patients-in-brazil
#10
LETTER
Jing-Lan Tang, Chun-Jie Hou
No abstract text is available yet for this article.
August 29, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28849422/the-more-from-east-asian-the-better-risk-prediction-of-colorectal-cancer-risk-by-gwas-identified-snps-among-japanese
#11
Makiko Abe, Hidemi Ito, Isao Oze, Masatoshi Nomura, Yoshihiro Ogawa, Keitaro Matsuo
BACKGROUND: Little is known about the difference of genetic predisposition for CRC between ethnicities; however, many genetic traits common to colorectal cancer have been identified. This study investigated whether more SNPs identified in GWAS in East Asian population could improve the risk prediction of Japanese and explored possible application of genetic risk groups as an instrument of the risk communication. METHODS: 558 Patients histologically verified colorectal cancer and 1116 first-visit outpatients were included for derivation study, and 547 cases and 547 controls were for replication study...
August 28, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28849413/prognostic-stratification-of-patients-with-metastatic-nasopharyngeal-carcinoma-using-a-clinical-and-biochemical-scoring-system
#12
Jeremy Chee, Kwok Seng Loh, Ivan Tham, Francis Ho, Lea Choung Wong, Chee Seng Tan, Boon Cher Goh, Chwee Ming Lim
PURPOSE: Metastatic nasopharyngeal cancer (NPC) is known to have poor survival outcomes. Clinical and biochemical parameters may impact survival outcomes among patients with metastatic NPC and may be used for prognostication. METHODS: One-hundred and fifty-eight patients with metastatic NPC treated at a single tertiary institution were analyzed retrospectively. Multivariate analysis was carried out on patients who were given disease control treatment (n = 135)...
August 28, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28849390/identification-of-prognostic-markers-of-high-grade-prostate-cancer-through-an-integrated-bioinformatics-approach
#13
Hai Huang, Qin Zhang, Chen Ye, Jian-Min Lv, Xi Liu, Lu Chen, Hao Wu, Lei Yin, Xin-Gang Cui, Dan-Feng Xu, Wen-Hui Liu
PURPOSE: Prostate cancer is one of the leading causes of cancer death for male. In the present study, we applied an integrated bioinformatics approach to provide a novel perspective and identified some hub genes of prostate cancer. METHOD: Microarray data of fifty-nine prostate cancer were downloaded from Gene Expression Omnibus. Gene Ontology and pathway analysis were applied for differentially expressed genes between high and low grade prostate cancer. Weighted gene coexpression network analysis was applied to construct gene network and classify genes into different modules...
August 28, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28849266/validity-of-eleven-prognostic-scores-with-respect-to-intra-and-extrahepatic-recurrence-of-hepatocellular-carcinoma-after-liver-transplantation
#14
A Bauschke, A Altendorf-Hofmann, H Kissler, A Koch, C Malessa, U Settmacher
INTRODUCTION: Tumor recurrence is the most frequent cause of death after liver transplantation for hepatocellular carcinoma. We selected ten other prognostic classifications to evaluate their potential to predict the risk of recurrence after LT for HCC as compared to the Milan classification. All of the other scores have not been compared with one another in a single cohort. METHODS: Data of 147 consecutive patients transplanted at our department between 1996 and 2014 were analyzed and staged for morphological and functional scores of underlying liver disease...
August 28, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28849265/safety-of-intraoperative-chemotherapy-with-5-fu-for-colorectal-cancer-patients-receiving-curative-resection-a-randomized-multicenter-prospective-phase-iii-ioccrc-trial-ioccrc
#15
Rong-Xin Zhang, Jun-Zhong Lin, Jian Lei, Gong Chen, Li-Ren Li, Zhen-Hai Lu, Pei-Rong Ding, Jiong-Qiang Huang, Ling-Heng Kong, Fu-Long Wang, Cong Li, Wu Jiang, Chuan-Feng Ke, Wen-Hao Zhou, Wen-Hua Fan, Qing Liu, De-Sen Wan, Xiao-Jun Wu, Zhi-Zhong Pan
PURPOSE: The safety and efficacy of intraoperative chemotherapy in colorectal cancer have not yet been extensively investigated. This randomized control trial was designed to compare the safety and efficacy of intraoperative chemotherapy in combination with surgical resection to those of traditional surgical resection alone. METHODS: From January 2011 to January 2016, 696 colorectal cancer patients were enrolled in this study: 341 patients were randomly assigned to the intraoperative chemotherapy, which consist of portal vein chemotherapy, intraluminal chemotherapy and intraperitoneal chemotherapy, plus surgery group, whereas 344 patients were randomized to the control group to undergo surgery alone...
August 28, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28840384/survival-benefit-of-pelvic-and-paraaortic-lymphadenectomy-in-high-grade-endometrial-carcinoma-a-retrospective-population-based-cohort-analysis
#16
Thomas Papathemelis, S Scharl, K Kronberger, M Gerken, A Scharl, A Pauer, M Klinkhammer-Schalke
OBJECTIVE: The standard therapy for high-grade endometrial cancer is surgery but the therapeutic effects of pelvic and paraaortic lymph node dissection (LND) are poorly investigated. In this study, we retrospectively evaluated overall survival, recurrence rates and recurrence-free survival among patients with high-grade type I and II endometrial carcinoma who underwent LND. METHODS: This study included 284 patients who are recorded in the German Tumor Centre Regensburg form 1998 to 2015 and were selected by cancer grading, the absence of secondary tumors, primary surgery including hysterectomy and available follow-up...
August 24, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28831650/modifiable-health-related-factors-smoking-physical-activity-and-body-mass-index-and-health-care-use-and-costs-among-adult-cancer-survivors
#17
Sapna Kaul, Jaqueline C Avila, Daniel Jupiter, Ana M Rodriguez, Anne C Kirchhoff, Yong-Fang Kuo
OBJECTIVE: To examine the associations between modifiable health-related factors, such as smoking, low physical activity and higher body mass index (BMI), and annual health care visits and expenditures among adult cancer survivors in the United States. METHODS: Using data from the 2010-2014 Medical Expenditures Panel Survey, we identified 4920 cancer survivors (aged 18-64 years) and a matched comparison group. Our outcomes were number of annual health care visits [i...
August 22, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28828692/systemic-inflammation-response-index-siri-cancer-stem-cells-and-survival-of-localised-gastric-adenocarcinoma-after-curative-resection
#18
Sen Li, Xiuwen Lan, Hongyu Gao, Zhiguo Li, Li Chen, Wenpeng Wang, Shubin Song, Yimin Wang, Chunfeng Li, Hongfeng Zhang, Yingwei Xue
PURPOSE: Systemic Inflammation Response Index (SIRI), based on peripheral neutrophil, monocyte, and lymphocyte counts, was recently developed and used as a marker to predict the survival of patients with malignant tumours. Cancer stem cells (CSCs) can contribute to gastric cancer progression and recurrence. It is not clear whether SIRI is associated with CSCs during gastric cancer development. METHODS: The SIRI was developed in a training cohort of 455 gastric cancer patients undergoing curative resection between 2007 and 2009, and validated in a validation cohort of 327 patients from 2010 to 2011...
August 21, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28828689/lenalidomide-in-combination-with-bendamustine-and-prednisolone-in-relapsed-refractory-multiple-myeloma-results-of-a-phase-2-clinical-trial-osho-077
#19
Juliane Beck, Andreas Schwarzer, Dietrich Gläser, Lars-Olof Mügge, Jens Uhlig, Simone Heyn, Brigitte Kragl, Martin Mohren, Franz Albert Hoffmann, Thoralf Lange, Thomas Schliwa, Thomas Zehrfeld, Cornelia Becker, Ute Kreibich, Cornelia Winkelmann, Thomas Edelmann, Marc Andrea, Marius Bill, Madlen Jentzsch, Sebastian Schwind, Dietger Niederwieser, Wolfram Pönisch
INTRODUCTION: While lenalidomide monotherapy is established for relapsed and/or refractory multiple myeloma (MM) treatment, combination therapies including lenalidomide are still under investigation in a number of phase 2/3 studies. In the current study, a treatment regime of lenalidomide (Revlimid(®)), bendamustine and prednisolone (RBP) was tested in patients with relapsed/refractory MM. METHODS: In the previously completed phase 1 study RBP with a dose of 75 mg/m(2) bendamustine days 1-2, prednisolone 100 mg days 1-4 and 25 mg lenalidomide days 1-21 was well tolerated...
August 21, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28828528/sentinel-lymph-node-mapping-in-endometrial-cancer-comparison-of-fluorescence-dye-with-traditional-radiocolloid-and-blue
#20
REVIEW
Andrea Papadia, Maria Luisa Gasparri, Alessandro Buda, Michael D Mueller
Sentinel lymph node (SLN) mapping in endometrial cancer (EMCA) is rapidly gaining acceptance in the clinical community. As compared to a full lymphadenectomy in every patient, to a selective lymphadenectomy after frozen section of uterus in selected patients with intrauterine risk factors or to a strategy in which a lymphadenectomy is always omitted, SLN mapping seems to be a reasonable and oncologically safe middle ground. Various protocols can be used when applying an SLN mapping. In this manuscript we review the characteristics, toxicity and clinical impact of technetium-99m radiocolloid (Tc-99m), of the blue dyes (methylene blue, isosulfan blue and patent blue) and of indocyanine green (ICG)...
August 21, 2017: Journal of Cancer Research and Clinical Oncology
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