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Journal of Cancer Research and Clinical Oncology

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https://www.readbyqxmd.com/read/30244390/the-ambiguous-role-of-microrna-205-and-its-clinical-potential-in-pancreatic-ductal-adenocarcinoma
#1
Max Michael Traeger, Jan Rehkaemper, Hansjoerg Ullerich, Konrad Steinestel, Eva Wardelmann, Norbert Senninger, Sameer Abdallah Dhayat
PURPOSE: Early treatment of pancreatic ductal adenocarcinoma (PDAC) is significantly delayed due to the lack of liquid biopsy markers for early diagnosis at surgically resectable tumor stages. Recent studies suggest that microRNA-205 (miR-205) is involved in PDAC progression by post-transcriptional regulation of epithelial-to-mesenchymal transition (EMT). However, the clinical potential of miR-205 as diagnostic and prognostic marker remains undefined and its exact role in PDAC is still ambiguous...
September 22, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30244389/efficacy-and-safety-analysis-of-the-german-expanded-access-program-of-osimertinib-in-patients-with-advanced-t790m-positive-non-small-cell-lung-cancer
#2
Jan A Stratmann, Sebastian Michels, Sofia Hornetz, Daniel C Christoph, Sandra Sackmann, Werner Spengler, Helge Bischoff, Monica Schäfer, Jürgen Alt, Annette Müller, Eckart Laack, Martin Kimmich, Frank Griesinger, Martin Sebastian
PURPOSE: Osimertinib, a third-generation irreversible mutant-selective inhibitor of EGFR kinase activity was clinically evaluated in the AURA trials, where it showed high clinical efficacy and a favorable toxicity profile in patients with acquired exon 20-EGFR pT790M mutation. We provide the clinical data of the German expanded access program that further characterizes the efficacy and safety of osimertinib in a heterogeneous patient population outside clinical trials. METHODS: We performed a retrospective data analysis on patients who were included into the German osimertinib EAP...
September 22, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30232558/everolimus-in-patients-with-multiply-relapsed-or-cisplatin-refractory-germ-cell-tumors-results-of-a-phase-ii-single-arm-open-label-multicenter-trial-radit-of-the-german-testicular-cancer-study-group
#3
Martin Fenner, Christoph Oing, Annette Dieing, Thomas Gauler, Karin Oechsle, Anja Lorch, Marcus Hentrich, Hans-Georg Kopp, Carsten Bokemeyer, Friedemann Honecker
BACKGROUND: Treatment options for patients (pts) with multiply relapsed or refractory metastatic germ cell cancer (GCC) are limited. The mTOR inhibitor everolimus has been approved for the treatment of different solid tumors and was assessed in refractory GCC within this phase II RADIT trial of the German Testicular Cancer Study Group. METHODS: GCC pts progressing during cisplatin-based salvage chemotherapy, or relapsing after high-dose chemotherapy, or failing at least two lines of cisplatin-based chemotherapy were eligible...
September 19, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30225541/microrna-338-5p-plays-a-tumor-suppressor-role-in-glioma-through-inhibition-of-the-mapk-signaling-pathway-by-binding-to-foxd1
#4
Xin-Long Ma, Feng Shang, Wei Ni, Jin Zhu, Bin Luo, Yu-Qi Zhang
PURPOSE: MicroRNAs (miRs) play an important role in many cancers and can affect cancer cell behavior, including glioma. This study aims at investigating the effects of miR-338-5p on the senescence, migration, invasion, and apoptosis of glioma cells via MAPK-signaling pathway by binding to FOXD1. METHODS: Gene expression microarray analysis was performed to screen differentially expressed miRNAs associated with glioma. Glioma tissues and adjacent tissues were collected...
September 17, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30225540/circulating-microrna-99-family-as-liquid-biopsy-marker-in-pancreatic-adenocarcinoma
#5
Anda J Stroese, Hansjoerg Ullerich, Gabriele Koehler, Verena Raetzel, Norbert Senninger, Sameer A Dhayat
PURPOSE: Recently, we identified the microRNA-99 family as unfavorable prognostic factor in patients with pancreatic ductal adenocarcinoma (PDAC). The aim of this study is to evaluate its value as circulating biomarker for PDAC. METHODS: Tissue and corresponding preoperative blood samples of 181 patients with PDAC UICC Stages I-IV (n = 90), intraductal papillary mucinous neoplasm (IPMN, n = 11), chronic pancreatitis (n = 40), pancreatic cystadenoma (n = 20), and age-matched healthy blood serum controls (n = 20) were collected between 2014 and 2017 prospectively...
September 17, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30225539/presence-and-activity-of-hpv-in-primary-lung-cancer
#6
Talita Helena Araujo de Oliveira, Carolina Medeiros do Amaral, Bianca de França São Marcos, Kamylla Conceição Gomes Nascimento, Ana Carine de Miranda Rios, Dafne Carolina Alves Quixabeira, Maria Tereza Cartaxo Muniz, Jacinto da Costa Silva Neto, Antonio Carlos de Freitas
PURPOSE: Evaluate the presence of human papillomavirus (HPV) in biopsies of Brazilian patients with lung cancer and also the expression of the E6 and E7 oncoproteins. HPV is widely known as an important condition for cervical cancer although evidence today shows it is associated with several other types of cancer and may also be involved in lung cancer development. However, there are some divergences regarding the presence and activity of HPV in lung carcinogenesis. METHODS: The detection of HPV was performed by PCR, followed by genotype and immunohistochemical evaluation of E6 and E7 HPV type specific, from 63 patients...
September 17, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30209612/modified-ajcc-staging-of-gastric-neuroendocrine-carcinoma-based-on-t-staging-can-improve-the-capacity-of-prognosis-assessment
#7
Jian-Wei Xie, Ping Li, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Ying-Hong Yang, De-Yong Kang, Chao-Hui Zheng, Chang-Ming Huang
BACKGROUND OR PURPOSE: This study was designed to determine the value of AJCC staging 7th edition and improved AJCC staging in assessing the prognosis of gastric neuroendocrine carcinoma (GNEC). METHODS: In total, GNEC 475 patients in the Surveillance, Epidemiology, and End Results (SEER) database and 129 GNEC patients in our department undergoing resection were included. The former served as the test group, and the latter served as the validation group. Those with stage IIIb disease were allocated into four subgroups, and improved AJCC staging was established...
September 12, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30209611/treatment-outcomes-of-intracranial-germinoma-a-retrospective-analysis-of-170-patients-from-a-single-institution
#8
Xin Lian, Xiaorong Hou, Junfang Yan, Shuai Sun, Zheng Miao, Zhikai Liu, Weiping Wang, Jing Shen, Jie Shen, Ke Hu, Fuquan Zhang
PURPOSE: To perform a retrospective analysis of patients with intracranial germinoma treated in our department to evaluate treatment outcomes and determine optimal treatment strategies. METHODS: We reviewed the treatment outcomes of 170 patients with intracranial germinoma who were treated in our department from January 1996 to January 2017. The median patient age was 15 years old. Among the patients, 56 (33%) were pathologically diagnosed, and 114 (67%) were diagnosed clinically...
September 12, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30203148/variability-in-her2-expression-between-primary-colorectal-cancer-and-corresponding-metastases
#9
Lina Shan, Yiming Lv, Bingjun Bai, Xuefeng Huang, Hongbo Zhu
PURPOSE: This study aimed to investigate the HER2 status of primary colorectal cancer (CRC) and corresponding metastases, and determine the correlation between HER2 and clinicopathological characteristics. METHODS: We collected the clinicopathological features of 98 CRC patients and 66 patients which were previously evaluated for the KRAS status. The tissue samples of primary CRC tumors (n = 98), noninvolved colorectal mucosa (n = 98), paired lymph nodes (n = 98, 69 patients had positive metastatic nodes), and liver metastases (n = 22) were evaluated using immunohistochemistry for HER2...
September 10, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30203147/correlation-of-genomic-alterations-between-tumor-tissue-and-circulating-tumor-dna-by-next-generation-sequencing
#10
Ya-Sian Chang, Hsin-Yuan Fang, Yao-Ching Hung, Tao-Wei Ke, Chieh-Min Chang, Ting-Yuan Liu, Yu-Chia Chen, Dy-San Chao, Hsi-Yuan Huang, Jan-Gowth Chang
PURPOSE: Analysis of circulating tumor DNA (ctDNA) offers an unbiased and noninvasive way to assess the genetic profiles of tumors. This study aimed to analyze mutations in ctDNA and their correlation with tissue mutations in patients with a variety of cancers. METHODS: We included 21 cancer patients treated with surgical resection for whom we collected paired tissue and plasma samples. Next-generation sequencing (NGS) of all exons was performed in a targeted human comprehensive cancer panel consisting of 275 genes...
September 10, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30196439/correction-to-the-impact-of-different-doses-of-indocyanine-green-on-the-sentinel-lymph-node-mapping-in-early-stage-endometrial-cancer
#11
Andrea Papadia, Alessandro Buda, Maria Luisa Gasparri, Giampaolo Di Martino, Beatrice Bussi, Debora Verri, Michael D Mueller
Unfortunately, the P value at multivariate analysis for ICG concentration in Table 3 was incorrectly published.
September 8, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30194485/pole-gene-hotspot-mutations-in-advanced-pancreatic-cancer
#12
Michael Guenther, Vivien Veninga, Joerg Kumbrink, Michael Haas, C Benedikt Westphalen, Stephan Kruger, Volker Heinemann, Thomas Kirchner, Stefan Boeck, Andreas Jung, Steffen Ormanns
PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, lacking relevant prognostic and predictive biomarkers. DNA polymerase epsilon (POLE) has important functions in the maintenance of genetic stability during DNA replication and has previously been associated with favorable prognosis in endometrial and colorectal cancer. However, its relevance in advanced pancreatic cancer (aPDAC) has not been examined to date. METHODS: Using pyrosequencing on tumoral DNA extracted from 60 samples from the AIO-PK0104 study as well as 55 samples from completed translational trials, we examined POLE hotspot mutations in exon 9 (P286R) and exon 13 (V411R/L/M) in the POLE gene exonuclease domain...
September 7, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30171333/the-gene-mutational-discrepancies-between-primary-and-paired-metastatic-colorectal-carcinoma-detected-by-next-generation-sequencing
#13
Shuang-Mei Zou, Wei-Hua Li, Wen-Miao Wang, Wen-Bin Li, Su-Sheng Shi, Jian-Ming Ying, Ning Lyu
PURPOSE: To better understand the gene mutational status and heterogeneity between primary and metastatic CRC (mCRC) using a sensitive sequencing method. METHODS: The mutational status of EGFR, KRAS, NRAS, PIK3CA, ERBB2, BRAF, KIT, and PDGFRA was analyzed in 65 patients, with 147 samples of primary and paired live or lung metastatic CRC, using next-generation sequencing (NGS), quantitative RT-PCR (qPCR), and Sanger sequencing. RESULTS: Fifteen cases (15/22, 68...
August 31, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30167888/prognostic-impact-of-hyperdiploidy-in-multiple-myeloma-patients-with-high-risk-cytogenetics-a-pilot-study-in-china
#14
Jiangang Mei, Yongping Zhai, Hanqing Li, Feng Li, Xiaogang Zhou, Ping Song, Qian Zhao, Yaping Yu, Zhiming An, Liping Wang
PURPOSE: Multiple myeloma is genetically heterogeneous with varied clinical outcomes, primarily due to the coexistence of diverse numerical and structural cytogenetic abnormalities. The prognostic impact of hyperdiploidy in myeloma patients with high-risk cytogenetics remains controversial in Western studies and is unknown in China. METHODS: We examined the cytogenetic features of hyperdiploidy in 201 Chinese patients with newly diagnosed myeloma using magnetic-activated cell sorting and interphase fluorescence in situ hybridization and analyzed the effect of hyperdiploidy on the prognosis of patients with high-risk cytogenetics...
August 24, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30167889/role-of-ferroptosis-in-hepatocellular-carcinoma
#15
REVIEW
Jianhua Nie, Binlin Lin, Meng Zhou, Li Wu, Tongsen Zheng
PURPOSE: Hepatocellular carcinoma (HCC) is a complicated disease with low survival rate due to frequent recurrence and the lack of efficient therapies. For advanced HCC, sorafenib, as the only approved first-line drug for HCC, improves the survival to some extent, but depressingly with severe adverse effects and emerging resistance conditions, which cause a poor prognosis. Ferroptosis is a new recognized way of non-apoptosis-regulated cell death, characterized by the iron-dependent accumulation of lipid hydroperoxides, showing a tremendous promising in the therapy of cancer, especially in HCC...
August 22, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30132118/evaluation-of-classical-clinical-endpoints-as-surrogates-for-overall-survival-in-patients-treated-with-immune-checkpoint-blockers-a-systematic-review-and-meta-analysis
#16
Howard L Kaufman, Lawrence H Schwartz, William N William, Mario Sznol, Kyle Fahrbach, Yingxin Xu, Eric Masson, Andrea Vergara-Silva
PURPOSE: Classical clinical endpoints [e.g., objective response rate (ORR), disease control rate (DCR), and progression-free survival (PFS)] may not be appropriate for immune checkpoint blockers (ICBs). We evaluated correlations between these endpoints and overall survival (OS) for surrogacy. METHODS: Randomized controlled trials (RCTs) of solid tumors patients treated with ICBs published between 01/2005 and 03/2017, and congress proceedings (2014-2016) were included...
August 21, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30128672/the-heat-shock-protein-47-as-a-potential-biomarker-and-a-therapeutic-agent-in-cancer-research
#17
REVIEW
Beatriz Dal Pont Duarte, Diego Bonatto
Heat shock protein 47 (HSP47) is an important chaperone required for the correct folding and secretion of collagen. Several studies revealed that HSP47 has a role in numerous steps of collagen synthesis, preventing procollagen aggregation and inducing hydroxylation of proline and lysine residues. HSP47 is encoded by the SERPINH1 gene, which is located on chromosome 11q13.5, one of the most frequently amplified regions in human cancer. The altered expression levels of HSP47 have been correlated with several types of cancer, such as cervical, breast, pancreatic and gastric cancers...
August 20, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30120542/low-radiographic-muscle-density-is-associated-with-lower-overall-and-disease-free-survival-in-early-stage-colorectal-cancer-patients
#18
Harm van Baar, S Beijer, M J L Bours, M P Weijenberg, M van Zutphen, F J B van Duijnhoven, G D Slooter, J F M Pruijt, J J Dronkers, A Haringhuizen, E J Spillenaar Bilgen, B M E Hansson, J H W de Wilt, E Kampman, R M Winkels
BACKGROUND: In cancer patients with a poor prognosis, low skeletal muscle radiographic density is associated with higher mortality. Whether this association also holds for early-stage cancer is not very clear. We aimed to study the association between skeletal muscle density and overall mortality among early-stage (stage I-III) colorectal cancer (CRC) patients. Furthermore, we investigated the association between skeletal muscle density and both CRC-specific mortality and disease-free survival in a subset of the study population...
August 17, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30116883/the-roles-of-pkcs-in-regulating-autophagy
#19
REVIEW
Tianyi Wang, Conghe Liu, Lili Jia
PURPOSE: Autophagy, as a highly conserved cellular degradation and recycling process, plays an important part in maintaining cellular homeostasis. PKC signaling is involved in multiple pathways including cell cycle progression, tumorigenesis, migration and autophagy. METHODS: Literatures about PKC and autophagy from PubMed databases were reviewed in this study. RESULTS: Studies regarding the association of PKC and autophagy remain debatable...
August 16, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30109501/platinum-based-concurrent-chemotherapy-remains-the-optimal-regimen-for-nasopharyngeal-carcinoma-a-large-institutional-based-cohort-study-from-an-endemic-area
#20
Yahui Yu, Hu Liang, Xing Lv, Liangru Ke, Wenze Qiu, Xinjun Huang, Guoying Liu, Wangzhong Li, Xiang Guo, Yanqun Xiang, Weixiong Xia
PURPOSE: To retrospectively investigate the optimal regimen of concurrent chemotherapy for nasopharyngeal carcinoma (NPC) by comparing clinical outcomes of patients who received platinum-based and non-platinum-based concurrent chemoradiotherapy (CCRT) regimens. METHODS: Based on a prospectively maintained database from 1998 to 2013 in an endemic area, a total of 4608 newly diagnosed, biopsy-proven, and non-disseminated NPC patients were identified and allocated into three cohorts based on concurrent chemotherapy regimens: cisplatin-based (CP) chemotherapy cohort, other platinum-based (OP) chemotherapy cohort, and non-platinum-based (NP) chemotherapy cohort...
August 14, 2018: Journal of Cancer Research and Clinical Oncology
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