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Journal of Cancer Research and Clinical Oncology

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https://www.readbyqxmd.com/read/28447160/cancer-of-the-ovary-fallopian-tube-and-peritoneum-a-population-based-comparison-of-the-prognostic-factors-and-outcomes
#1
Miriam Rottmann, A Burges, S Mahner, C Anthuber, T Beck, D Grab, A Schnelzer, M Kiechle, D Mayr, M Pölcher, G Schubert-Fritschle, J Engel
PURPOSE: The objective was to compare the prognostic factors and outcomes among primary ovarian cancer (OC), fallopian tube cancer (FC), and peritoneal cancer (PC) patients in a population-based setting. METHODS: We analysed 5399 OC, 327 FC, and 416 PC patients diagnosed between 1998 and 2014 in the catchment area of the Munich Cancer Registry (meanwhile 4.8 million inhabitants). Tumour site differences were examined by comparing prognostic factors, treatments, the time to progression, and survival...
April 26, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28439713/personalized-axillary-dissection-the-number-of-excised-lymph-nodes-of-nodal-positive-breast-cancer-patients-has-no-significant-impact-on-relapse-free-and-overall-survival
#2
Florian Ebner, Achim Wöckel, Wolfgang Janni, Rolf Kreienberg, Lukas Schwentner, Manfred Wischnewsky
PURPOSE: Sentinel lymph node (SLN) biopsy has replaced axillary lymph node dissection (ALND) for the staging of clinically node-negative breast cancer patients (BCP), demonstrating equivalent survival to ALND while resulting in reduced morbidity. ALND has remained the standard of care for the majority of BCP with clinical axillary metastases or metastases found on SLN biopsy. More recently, it is debated whether ALND could be avoided not only in SLN-negative BCP but also in selected SLN-positive disease or even in all patients...
April 24, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28434043/early-whole-brain-radiotherapy-in-primary-cns-lymphoma-negative-impact-on-quality-of-life-in-the-randomized-g-pcnsl-sg1-trial
#3
Ulrich Herrlinger, Niklas Schäfer, Rolf Fimmers, Frank Griesinger, Michael Rauch, Heinz Kirchen, Patrick Roth, Martin Glas, Michael Bamberg, Peter Martus, Eckhard Thiel, Agnieszka Korfel, Michael Weller
PURPOSE: In the randomized G-PCNSL-SG-1 trial, the addition of whole brain radiotherapy (45 Gy) to high-dose methotrexate (HD-MTX)-based chemotherapy (early WBRT arm) did not prolong overall survival (OS) as compared to HD-MTX-based chemotherapy alone (no early WBRT arm) in primary CNS lymphoma (PCNSL) patients. To determine whether WBRT might lead to quality of life (QoL)-relevant late neurotoxicity, this trial prospectively monitored QoL. METHODS: QoL measurements were performed using the EORTC-QLQ-C30 and BN20 questionnaires and combined with repeated Mini Mental State Examinations (MMSE)...
April 22, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28434042/erratum-to-curcumin-induces-g2-m-arrest-apoptosis-nf-%C3%AE%C2%BAb-inhibition-and-expression-of-differentiation-genes-in-thyroid-carcinoma-cells
#4
Suzan Schwertheim, Frederik Wein, Klaus Lennartz, Karl Worm, Kurt Werner Schmid, Sien-Yi Sheu-Grabellus
No abstract text is available yet for this article.
April 22, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28432456/deregulated-bcl-2-family-proteins-impact-on-repair-of-dna-double-strand-breaks-and-are-targets-to-overcome-radioresistance-in-lung-cancer
#5
Sarah A Wieczorek, Frank Breitenbuecher, Aashish Soni, Katja Paul-Konietzko, Sophie Ziegler, Ali Sak, George Iliakis, Martin Schuler
PURPOSE: DNA damage-induced cell death is a major effector mechanism of radiotherapy. Aberrant expression of anti-apoptotic BCL-2 family proteins is frequently observed in lung cancers. Against this background, we studied radioresistance mediated by BCL-2 family proteins at the mechanistic level and its potential as target for radiochemotherapy. METHODS: Lung cancer models stably expressing BCL-xL or MCL-1 were irradiated to study cell death, clonogenic survival, and DNA repair kinetics in vitro, and growth suppression of established tumors in vivo...
April 21, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28432455/dual-activation-of-toll-like-receptors-7-and-9-impairs-the-efficacy-of-antitumor-vaccines-in-murine-models-of-metastatic-breast-cancer
#6
Mariela A Moreno Ayala, María Florencia Gottardo, María Soledad Gori, Alejandro Javier Nicola Candia, Carla Caruso, Andrea De Laurentiis, Mercedes Imsen, Slobodanka Klein, Elisa Bal de Kier Joffé, Gabriela Salamone, Maria G Castro, Adriana Seilicovich, Marianela Candolfi
PURPOSE: Since combination of Toll-like receptor (TLR) ligands could boost antitumor immunity, we evaluated the efficacy of dendritic cell (DC) vaccines upon dual activation of TLR9 and TLR7 in breast cancer models. METHODS: DCs were generated from mouse bone marrow or peripheral blood from healthy human donors and stimulated with CpG1826 (mouse TLR9 agonist), CpG2006 or IMT504 (human TLR9 agonists) and R848 (TLR7 agonist). Efficacy of antitumor vaccines was evaluated in BALB/c mice bearing metastatic mammary adenocarcinomas...
April 21, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28429102/improved-systemic-treatment-for-early-breast-cancer-improves-cure-rates-modifies-metastatic-pattern-and-shortens-post-metastatic-survival-35-year-results-from-the-munich-cancer-registry
#7
Dieter Hölzel, Renate Eckel, Ingo Bauerfeind, Bernd Baier, Thomas Beck, Michael Braun, Johannes Ettl, Ulrich Hamann, Marion Kiechle, Sven Mahner, Christian Schindlbeck, Johann de Waal, Nadia Harbeck, Jutta Engel
PURPOSE: Systemic therapies (ATHs) in early breast cancer have improved the survival of breast cancer (BC) patients in recent decades. The magnitude of the changes in overall, metastasis-free (MFS) and post-metastatic (PMS) survival and in the metastasis (MET) pattern will be described. PATIENT AND METHODS: We analysed 60,227 patients with a diagnosis of T-N-M0 BC between 1978 and 2013 and 11,983 patients with metastases (MET) in the Munich Cancer Registry. Patients will be divided into four time periods to identify relationships between BC and METs...
April 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28429101/human-circulating-and-tissue-gastric-cancer-stem-cells-display-distinct-epithelial-mesenchymal-features-and-behaviors
#8
Shengliang Zhang, Yanna Shang, Tie Chen, Xin Zhou, Wengtong Meng, Chuanwen Fan, Ran Lu, Qiaorong Huang, Xue Li, Xu Hong, Zongguang Zhou, Jiankun Hu, Xianming Mo
INTRODUCTION: Metastasis is a leading cause of cancer-related-deaths worldwide. Recently, cancer stem cells (CSCs) have been believed to be responsible for tumor initiation and metastasis, but till now, difference of cellular features and behaviors between CSCs from tumor tissues (TCSCs) and circulation (CCSCs) remains largely unknown, which hinders the progression of targeted therapies for metastasis. METHODS AND RESULTS: Here, we provide the features of circulating gastric cancer stem cells (CGCSCs) isolated from human gastric adenocarcinoma...
April 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28429100/conversion-of-hormone-and-her-2-receptor-in-metachronous-neck-metastases-from-breast-carcinoma
#9
Andreas Nauroth, Matthias Kalder, Marion Rössler, Gunnar Wichmann, Andreas Dietz, Susanne Wiegand
PURPOSE: Metastases are a common event in breast cancer. The expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) is essential for therapy and prognosis, and their conversion during disease progression potentially affects the treatment regimen. The aim was to analyze the estrogen, progesterone and HER-2 receptor expression in primary tumors and metachronous neck metastases from patients with breast cancer. METHODS: A retrospective analysis of 27 patients with breast cancer and metachronous neck metastasis was performed...
April 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28424903/zcchc12-a-novel-oncogene-in-papillary-thyroid-cancer
#10
Ouchen Wang, Zhouci Zheng, Qingxuan Wang, Yixiang Jin, Wenxu Jin, Yinghao Wang, Endong Chen, Xiaohua Zhang
PURPOSE: Thyroid cancer is the most common endocrine malignancy worldwide. The molecular mechanisms underlying thyroid tumorigenesis remain unclear. Some studies suggested that the ZCCHC12 gene correlates with certain diseases. However, the function of ZCCHC12 in thyroid cancer has yet to be determined. This study investigated the role of the ZCCHC12 gene in papillary thyroid cancer (PTC). METHODS: We conducted a comprehensive analysis of massively parallel whole-transcriptome resequencing of matched PTC tumors and normal tissues in 19 patients...
April 19, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28424902/physical-and-psychosocial-aspects-of-adolescent-and-young-adults-after-allogeneic-hematopoietic-stem-cell-transplantation-results-from-a-prospective-multicenter-trial
#11
Kristin Pulewka, Daniel Wolff, Philipp Y Herzberg, Hildegard Greinix, Pia Heussner, Friederike H A Mumm, Stephanie von Harsdorf, Kathrin Rieger, Philipp Hemmati, Andreas Hochhaus, Inken Hilgendorf
PURPOSE: Allogeneic hematopoietic stem-cell transplantation (alloHSCT) is physically and psychosocially demanding. Among transplant recipients, adolescent and young adults (AYA) represent a special group, as disease occurs early in life, resulting in the prospect of long survival time and high burden of alloHSCT sequelae. However, data focusing on AYA undergoing alloHSCT are rare. METHODS: Data resulting from a prospective multicenter trial initially focusing on graft-versus-host disease (GvHD) after alloHSCT were reused to analyse the differences between AYA and elderly patients...
April 19, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28417195/rrx-001-protects-against-cisplatin-induced-toxicities
#12
Bryan Oronsky, Tony R Reid, Christopher Larson, Corey A Carter, Christina E Brzezniak, Arnold Oronsky, Pedro Cabrales
PURPOSE: RRx-001, a minimally toxic tumor-associated macrophage and neutrophil-repolarizing agent, is under investigation in Phase II clinical trials as a sensitizer/resensitizer to cisplatin and carboplatin. On the basis of anecdotal clinical observations of improved platinum tolerability following a priming period with RRx-001 as well as preclinical studies that have previously demonstrated radioprotection of intestinal stem cells and cardioprotection from doxorubicin, the in vivo cytoprotective potential of RRx-001 pretreatment against cisplatin-induced bone marrow suppression and renal toxicity was investigated...
April 17, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28417194/impact-of-bcl2-polymorphisms-on-survival-in-transitional-cell-carcinoma-of-the-bladder
#13
Jochen Hess, Patrick Stelmach, Andreas Eisenhardt, Herbert Rübben, Henning Reis, Kurt Werner Schmid, Hagen Sjard Bachmann
PURPOSE: To evaluate the impact of three BCL2 single-nucleotide polymorphisms, i.e., c.-938C>A (rs2279115), c.21G>A (rs1801018), and c.*2203A>G (rs4987853) on survival in patients with transitional cell carcinoma of the bladder. METHODS: We analyzed 179 patients who underwent surgical treatment for bladder cancer at the Clinic of Urology, University Hospital Essen, Germany. Genomic DNA was extracted and genotyped for the polymorphisms. For all polymorphisms, linkage analysis was performed...
April 17, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28409273/development-of-a-novel-prognostic-signature-of-long-non-coding-rnas-in-lung-adenocarcinoma
#14
Shanbo Zheng, Difan Zheng, Chuanpeng Dong, Jiahua Jiang, Juntao Xie, Yihua Sun, Haiquan Chen
OBJECTIVES: Increasing evidence suggests that long non-coding RNAs (lncRNAs) may play a crucial role in many biological processes in a variety of cancers and serve as the basis for many clinical applications including prognostic biomarkers and potential therapeutic targets. The aim of this study is to develop a prognostic lncRNA signature with RNA-seq data in lung adenocarcinomas. METHODS: LncRNA expression profiles and clinical data of lung adenocarcinoma patients from The Cancer Genome Atlas (TCGA) were analyzed...
April 13, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28409272/increased-trace-amine-associated-receptor-1-taar1-expression-is-associated-with-a-positive-survival-rate-in-patients-with-breast-cancer
#15
Aurelia Vattai, Elif Akyol, Christina Kuhn, Simone Hofmann, Helene Heidegger, Franz von Koch, Kerstin Hermelink, Rachel Wuerstlein, Nadia Harbeck, Doris Mayr, Christine Spitzweg, Bettina Toth, Sven Mahner, Udo Jeschke, Nina Ditsch
PURPOSE: A correlation between breast cancer and thyroid disorders has been described in previous studies. Degraded thyroid hormones are referred to as trace amines. These endogenous amines have the ability to bind to the G-protein-coupled receptor TAAR1 (trace amine-associated receptor) and thereby activate it. TAAR1 is able to modulate the serotonergic and dopaminergic system in the brain and has so far been studied in the neurological field. The following study represents the first investigation of the regulation of TAAR1 in primary breast cancer (no metastases, M0)...
April 13, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28405827/mgmt-promoter-methylation-status-in-merkel-cell-carcinoma-in-vitro-versus-invivo
#16
Giuseppina Improta, Cathrin Ritter, Angela Pettinato, Valeria Vasta, David Schrama, Filippo Fraggetta, Jürgen C Becker
PURPOSE: Expression of O6-methylguanine-DNA methyltransferase (MGMT) in Merkel cell carcinoma (MCC) is very variable; thus, we tested whether this may be due to differential methylation of the MGMT gene promoter. METHODS: Quantitative analysis of MGMT mRNA and protein expression, as well as MGMT promoter methylation status, was performed in a series of tissue samples of MCC tumors, representing both primary and metastatic lesions, as well as in six MCC cell lines...
April 12, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28405826/everolimus-as-first-line-therapy-for-pancreatic-neuroendocrine-tumours-current-knowledge-and-future-perspectives
#17
REVIEW
Marco Gallo, Pasqualino Malandrino, Giuseppe Fanciulli, Francesca Rota, Antongiulio Faggiano, Annamaria Colao
PURPOSE: Everolimus has been shown to be effective for advanced pancreatic neuroendocrine tumours (pNETs), but its positioning in the therapeutic algorithm for pNETs is matter of debate. METHODS: With the aim to shed light on this point, we performed an up-to-date critical review taking into account the results of both retrospective and prospective published studies, and the recommendations of international guidelines. In addition, we performed an extensive search on the Clinical Trial Registries databases worldwide, to gather information on the ongoing clinical trials related to this specific topic...
April 12, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28401302/combinatorial-therapy-with-adenoviral-mediated-pten-and-a-pi3k-inhibitor-suppresses-malignant-glioma-cell-growth-in-vitro-and-in-vivo-by-regulating-the-pi3k-akt-signaling-pathway
#18
Yang Nan, Liyun Guo, Yunpeng Song, Le Wang, Kai Yu, Qiang Huang, Yue Zhong
PURPOSE: Glioblastoma is a highly invasive and challenging tumor of the central nervous system. The mutation/deletion of the tumor suppressor phosphatase and tensin homolog (PTEN) gene is the main genetic change identified in glioblastomas. PTEN plays a critical role in tumorigenesis and has been shown to be an important therapeutic target. The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 is commonly used to inhibit glioma cell growth via regulation of the PI3K/AKT signaling pathway...
April 11, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28396948/a-novel-classification-scheme-for-advanced-laryngeal-cancer-midline-involvement-implications-for-the-contralateral-neck
#19
Arne Böttcher, Heidi Olze, Nadine Thieme, Carmen Stromberger, Steffen Sander, Adrian Münscher, Johannes Bier, Steffen Knopke
PURPOSE: There are insufficient data concerning risk factors for contralateral regional metastases in laryngeal cancer. The aim of this study was to investigate the frequency and risk factors for contralateral lymph node metastases and their dependence on midline involvement of the primary tumor in patients with advanced laryngeal squamous cell carcinoma. METHODS: 58 consecutive patients (8 females, 50 males; mean age 64.2 ± 9.8 years; AJCC stage III disease in 43...
April 10, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28393270/mitochondrial-dna-variants-in-colorectal-carcinogenesis-drivers-or-passengers
#20
REVIEW
Edoardo Errichiello, Tiziana Venesio
INTRODUCTION: Mitochondrial DNA alterations have widely been reported in many age-related degenerative diseases and tumors, including colorectal cancer. In the past few years, the discovery of inter-genomic crosstalk between nucleus and mitochondria has reinforced the role of mitochondrial DNA variants in perturbing this essential signaling pathway and thus indirectly targeting nuclear genes involved in tumorigenic and invasive phenotype. FINDINGS: Mitochondrial dysfunction is currently considered a crucial hallmark of carcinogenesis as well as a promising target for anticancer therapy...
April 9, 2017: Journal of Cancer Research and Clinical Oncology
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