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Journal of Cancer Research and Clinical Oncology

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https://www.readbyqxmd.com/read/27933395/influence-of-the-her-receptor-ligand-system-on-sensitivity-to-cetuximab-and-trastuzumab-in-gastric-cancer-cell-lines
#1
Julia Kneissl, Anja Hartmann, Nicole Pfarr, Franziska Erlmeier, Thomas Lorber, Simone Keller, Gwen Zwingenberger, Wilko Weichert, Birgit Luber
PURPOSE: Gastric cancer remains a major health concern, and improvement of the therapeutic options is crucial. Treatment with targeted therapeutics such as the EGFR-targeting antibody cetuximab or the HER2-targeting antibody trastuzumab is either ineffective or moderately effective in this disease, respectively. In this study, we analysed the involvement of the HER receptor ligands amphiregulin (AREG), epidermal growth factor (EGF), heparin-binding epidermal growth factor (HB-EGF) and transforming growth factor alpha (TGFα) in the responsiveness of gastric cancer cell lines to cetuximab and trastuzumab...
December 8, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27933394/men-and-women-show-similar-survival-rates-after-breast-cancer
#2
Paulo Franscisco Mascarenhas Bender, Letícia Lima de Oliveira, Célia Regina Costa, Suzana Sales de Aguiar, Anke Bergmann, Luiz Claudio Santos Thuler
PURPOSE: To compare the disease-free survival (DFS) and overall survival (OS) rates of men and women undergoing treatment for breast cancer. METHODS: A retrospective cohort study of patients with breast cancer diagnosed and treated at the Cancer Hospital III of the National Cancer Institute of Brazil, Rio de Janeiro, Brazil, between 1999 and 2013. Male breast cancer cases were matched for age, year of diagnosis, and clinical staging to three female cases (1:3). Patient characteristics were abstracted from hospital records and medical charts...
December 8, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27928645/braf-v600e-dependent-role-of-autophagy-in-uveal-melanoma
#3
Yinu Zhao, Weibin Wang, Irene Min, Brian Wyrwas, Maureen Moore, Rasa Zarnegar, Thomas J Fahey
BACKGROUND: Autophagy can function in a dual role in cancer development and progression: It can be cytoprotective or contribute to cell death. Therefore, determining the contextual role of autophagy between these two opposing effects is important. So far, little is known about the role of autophagy in uveal melanoma. In the present study, we looked to investigate the autophagic process, as well as its effect on cell survival in uveal melanoma cell lines under stressed conditions (starvation)...
December 7, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27921276/relationship-between-physician-adjudicated-adverse-events-and-patient-reported-health-related-quality-of-life-in-a-phase-ii-clinical-trial-nct01143402-of-patients-with-metastatic-uveal-melanoma
#4
Thomas M Atkinson, Jennifer L Hay, Alexander Shoushtari, Yuelin Li, Daniel J Paucar, Sloane C Smith, Ragini R Kudchadkar, Austin Doyle, Jeffrey A Sosman, Jorge Fernando Quevedo, Mohammed M Milhem, Anthony M Joshua, Gerald P Linette, Thomas F Gajewski, Jose Lutzky, David H Lawson, Christopher D Lao, Patrick J Flynn, Mark R Albertini, Takami Sato, Karl Lewis, Brian Marr, David H Abramson, Mark Andrew Dickson, Gary K Schwartz, Richard D Carvajal
PURPOSE: Clinical trials commonly use physician-adjudicated adverse event (AE) assessment via the common terminology criteria for adverse events (CTCAE) for decision-making. Patient-reported health-related quality of life (HRQoL) data are becoming more frequent in oncology; however, the relationship between physician-adjudicated AE assessment and HRQoL is understudied. METHODS: Data from a phase II trial (clinicaltrials.gov identifier: NCT01143402) where patients with metastatic uveal melanoma were randomized to receive selumetinib, an oral MEK inhibitor, or chemotherapy were analyzed...
December 5, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27921275/preoperative-characteristics-of-the-p-r-o-s-t-a-t-e-scores-a-novel-predictive-tool-for-the-risk-of-positive-surgical-margin-after-radical-prostatectomy
#5
Ben Xu, Cheng Luo, Qian Zhang, Jie Jin
OBJECTIVES: To propose a novel scoring system to predict the risk of positive surgical margin (PSM) after radical prostatectomy (RP) in prostate cancer (PCa) patients. MATERIALS AND METHODS: Eight reproducible variables available from preoperative characteristics of PCa patients were measured: PSA level (P), ratio of positive biopsy needles (R), obesity (O), scores of Gleason (S), T stage by preoperative MRI scan (T), age (A), tumor volume (T) and experience of the surgeon (E)...
December 5, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27913867/comparison-of-different-concepts-for-interpretation-of-chromosomal-aberrations-in-urothelial-cells-detected-by-fluorescence-in-situ-hybridization
#6
Johannes Mischinger, Lutz Philipp Guttenberg, Jörg Hennenlotter, Georgios Gakis, Stefan Aufderklamm, Steffen Rausch, Eva Neumann, Jens Bedke, Stefan Kruck, Christian Schwentner, Arnulf Stenzl, Tilman Todenhöfer
PURPOSE: Urine fluorescence in situ hybridization (FISH) has become a broadly used marker for noninvasive detection of bladder cancer (BC). However, it has been discussed whether the interpretation algorithm proposed by the manufacturer could be improved. Aim of the present study was to compare alternative evaluation strategies of FISH for detection of BC. METHODS: We included 1048 patients suspicious for BC, who underwent urine FISH examination before cystoscopy (diagnostic cohort)...
December 2, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27909811/plasma-microrna-103-microrna-107-and-microrna-194-levels-are-not-biomarkers-for-human-diffuse-gastric-cancer
#7
LETTER
Isao Oze, Shu Shimada, Hiromi Nagasaki, Yoshimitsu Akiyama, Miki Watanabe, Yasushi Yatabe, Keitaro Matsuo, Yasuhito Yuasa
PURPOSE: Diffuse-type gastric cancer (DGC) carries a poor prognosis. Effective screening is one measure that might improve the prognosis of this disease. An E-cadherin/p53 double-conditional knockout (DCKO) mouse line recapitulates human DGC morphologically and molecularly. Three circulating microRNAs (miRNA) (miR-103, miR-107, miR-194) in DCKO mice have been identified as biomarkers for DGC. We sought to evaluate whether these circulating miRNAs could be used for the detection of human DGC...
December 1, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27909810/erratum-to-differential-somatostatin-and-cxcr4-chemokine-receptor-expression-in-malt-type-lymphoma-of-gastric-and-extragastric-origin
#8
Susann Stollberg, Daniel Kaemmerer, Elisa Neubauer, Stefan Schulz, Ingrid Simonitsch-Klupp, Barbara Kiesewetter, Markus Raderer, Amelie Lupp
No abstract text is available yet for this article.
December 1, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27896440/a-phase-iii-open-label-randomized-multicenter-controlled-trial-of-oral-versus-intravenous-treosulfan-in-heavily-pretreated-recurrent-ovarian-cancer-a-study-of-the-north-eastern-german-society-of-gynecological-oncology-noggo
#9
Jalid Sehouli, Oliver Tomè, Desislava Dimitrova, Oumar Camara, Ingo Bernhard Runnebaum, Hans Werner Tessen, Beate Rautenberg, Radoslav Chekerov, Mustafa Zelal Muallem, Michael Patrick Lux, Tanja Trarbach, Gerald Gitsch
OBJECTIVE: In recurrent ovarian cancer (ROC), there is a high demand on effective therapies with a mild toxicity profile. Treosulfan is an alkylating agent approved as oral (p.o.) and intravenous (i.v.) formulation for the treatment of recurrent ovarian cancer. Data on safety and efficacy for either formulation are rare. For the first time we conducted a randomized phase III study comparing both formulations in women with ROC. METHODS: Patients having received at least two previous lines of chemotherapy were randomly assigned to one of two treatment arms: treosulfan i...
November 28, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27878363/improvement-of-overall-survival-in-stage-iv-melanoma-patients-during-2011-2014-analysis-of-real-world-data-in-441-patients-of-the-german-central-malignant-melanoma-registry-cmmr
#10
Andrea Forschner, Felizitas Eichner, Teresa Amaral, Ulrike Keim, Claus Garbe, Thomas Kurt Eigentler
BACKGROUND: During 2011 and 2014, new treatment modalities like tyrosine kinase inhibitors and checkpoint inhibitors were introduced into the therapy of metastatic melanoma. This study addresses the question whether overall survival (OS) of metastatic melanoma patients has already been improved in 441 patients diagnosed with metastatic melanoma between 2011 and 2014 in the real-world setting at the University Hospital Tuebingen. METHODS: All patients were documented with their different therapies by the CMMR and followed up until March 2016...
November 22, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27858163/expression-of-piwil3-in-primary-and-metastatic-melanoma
#11
Thilo Gambichler, Christina Kohsik, Ann-Kathrin Höh, Kerstin Lang, Heiko U Käfferlein, Thomas Brüning, Eggert Stockfleth, Markus Stücker, Max Dreißigacker, Michael Sand
PURPOSE: The PIWI-interacting RNA machinery in malignant melanoma (MM) has not been sufficiently studied. We aimed to investigate the PIWIL3 expression profiles in primary melanomas and metastases of MM including a correlation with clinical data. METHODS: We studied 161 primary melanomas, 45 lymph node metastases, and 16 distant metastases of 183 patients with MM. We used immunohistochemistry to assess PIWIL3 protein expression in situ. The relationship between the immunoreactivity of PIWIL3 and clinical data was statistically evaluated...
November 17, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27858162/downregulated-klk13-expression-in-bladder-cancer-highlights-tumor-aggressiveness-and-unfavorable-patients-prognosis
#12
Theodoros Tokas, Margaritis Avgeris, Christos Alamanis, Andreas Scorilas, Konstantinos G Stravodimos, Constantinos A Constantinides
PURPOSE: Despite recent research advantages on the molecular and subcellular background, bladder cancer (BlCa) remains a clinically neglected malignancy. This is strongly reflected by the generic approach of disease diagnosis and management. Additionally, patients' prognosis became a rather demanding task due to the great disease heterogeneity. Here, we aimed to evaluate, for the first time, the clinical value of KLK13 in BlCa. METHODS: A total of 279 bladder specimens (137 tumors, 107 adjacent normal tissues and 35 healthy samples) were included...
November 17, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27853869/survival-of-de-novo-stage-iv-breast-cancer-patients-over-three-decades
#13
Dieter Hölzel, Renate Eckel, Ingo Bauerfeind, Bernd Baier, Thomas Beck, Michael Braun, Johannes Ettl, Ulrich Hamann, Nadia Harbeck, Marion Kiechle, Sven Mahner, Christian Schindlbeck, Johann de Waal, Jutta Engel
BACKGROUND: De novo stage IV breast cancer patients (BCIV) depict a clinical picture not influenced by adjuvant therapy. Therefore, the time-dependent impact of changes in diagnostics and treatments on progression and survival can best be evaluated in this subgroup. METHODS: BCIV patients from 1978 to 2013 registered in the Munich Cancer Registry were divided into four periods, and the trends were analysed. Survival was estimated by Kaplan-Meier methods, and prognostic factors were fitted with Cox proportional hazard models...
November 16, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27844145/presence-of-sarcomatoid-differentiation-as-a-prognostic-indicator-for-survival-in-surgically-treated-metastatic-renal-cell-carcinoma
#14
Liangyou Gu, Hongzhao Li, Hanfeng Wang, Xin Ma, Lei Wang, Luyao Chen, Wenlei Zhao, Yu Zhang, Xu Zhang
PURPOSE: To assess the prognostic significance of sarcomatoid differentiation for surgically treated metastatic renal cell carcinoma (mRCC). METHODS: Patients undergoing cytoreductive nephrectomy for mRCC in our center between 2006 and 2014 were included. All enrolled patients were separated into two groups according to the presence of sarcomatoid differentiation. Clinical and pathological variables were recorded. Student's t test or Chi-square test was applied to compare them...
November 14, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27838786/53bp1-loss-induces-chemoresistance-of-colorectal-cancer-cells-to-5-fluorouracil-by-inhibiting-the-atm-chk2-p53-pathway
#15
Jing Yao, Ai Huang, Xiumei Zheng, Tao Liu, Zhenyu Lin, Sheng Zhang, Qin Yang, Tao Zhang, Hong Ma
PURPOSE: Loss of P53 binding protein 1 (53BP1) is considered a poor prognostic factor for colorectal cancer. However, its effect on chemosensitivity of colorectal cancer to 5-fluorouracil (5-FU) remains elusive. This study aimed to examine the association of 53BP1 expression with chemosensitivity of colorectal cancer cells to 5-FU. METHODS: Immunohistochemistry was performed on 30 metastatic colorectal cancer samples to assess the associations of 53BP1 levels with clinical therapeutic effects...
November 12, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27837281/cancer-and-hereditary-haemorrhagic-telangiectasia
#16
LETTER
A E Hosman, C L Shovlin
OBJECTIVE: To examine associations between cancer incidence and hereditary haemorrhagic telangiectasia (HHT). METHODS: Two studies with contrasting conclusions were compared. The first had used a registry-based, matched-pairs approach, while the second utilised HHT family-based, survey methodology. RESULTS: The first manuscript captured data on cancer incidence in a total of 316,581 matched cancer patients-non-cancer controls, which included 431 HHT cases...
November 11, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27834005/figo-stage-iiic-endometrial-cancer-identification-among-patients-with-complex-atypical-hyperplasia-grade-1-and-2-endometrioid-endometrial-cancer-laparoscopic-indocyanine-green-sentinel-lymph-node-mapping-versus-frozen-section-of-the-uterus-why-get-around-the
#17
Andrea Papadia, Maria Luisa Gasparri, Franziska Siegenthaler, Sara Imboden, Stefan Mohr, Michael D Mueller
PURPOSE: To compare two surgical strategies used to identify lymph node metastases in patients with preoperative diagnosis of complex atypical hyperplasia (CAH), grade 1 and 2 endometrial cancer (EC). METHODS: Data on patients with preoperative diagnosis of CAH, grade 1 and 2 EC undergoing laparoscopic indocyanine green (ICG) sentinel lymph node (SLN) mapping followed by frozen section of the uterus were collected. When risk factors were identified at frozen section, patients were subjected to a systematic lymphadenectomy...
November 11, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27832356/risk-factors-for-intestinal-metaplasia-in-a-southeastern-chinese-population-an-analysis-of-28-745-cases
#18
Jian-Xia Jiang, Qing Liu, Bing Zhao, Hai-Han Zhang, Huai-Ming Sang, Soyfoo-Muhammad Djaleel, Guo-Xin Zhang, Shun-Fu Xu
PURPOSE: To identify risk factors for intestinal metaplasia in a southeastern Chinese population. METHODS: Subjects who underwent upper GI endoscopy and endoscopic biopsy in the First Affiliated Hospital of Nanjing Medical University from 2008 to 2013 were included into this study. Various demographic, geographic, clinical and pathological data were analyzed separately to identify risk factors for intestinal metaplasia. RESULTS: The incidence of intestinal metaplasia differed significantly in 17 municipal areas ranging from 16...
November 10, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27826686/resin-based-yttrium-90-microspheres-for-unresectable-and-failed-first-line-chemotherapy-intrahepatic-cholangiocarcinoma-preliminary-results
#19
Zhongzhi Jia, Ricardo Paz-Fumagalli, Gregory Frey, David M Sella, J Mark McKinney, Weiping Wang
PURPOSE: To evaluate the value of resin-based yttrium-90 ((90)Y) radioembolization for unresectable and failed first-line chemotherapy (cisplatin plus gemcitabine) intrahepatic cholangiocarcinoma (ICC). METHODS: From February 2006 to September 2015, a retrospective study was conducted of all patients who underwent resin-based (90)Y therapy for unresectable and failed first-line chemotherapy ICC. Tumor response was assessed using modified RECIST criteria; side effects were assessed using Common Terminology Criteria for Adverse Events version 4...
November 8, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27812854/sentinel-lymph-node-mapping-in-patients-with-stage-i-endometrial-carcinoma-a-focus-on-bilateral-mapping-identification-by-comparing-radiotracer-tc99-m-with-blue-dye-versus-indocyanine-green-fluorescent-dye
#20
Andrea Papadia, Ignacio Zapardiel, Beatrice Bussi, Fabio Ghezzi, Marcello Ceccaroni, Elena De Ponti, Federica Elisei, Sara Imboden, Begoña Diaz de la Noval, Maria Luisa Gasparri, Giampaolo Di Martino, Javier De Santiago, Michael Mueller, Francesca Vecchione, Federica Dell'Orto, Alessandro Buda
PURPOSE: The aim of this study was to compare technetium radiocolloid (Tc99(m)) + blue dye (BD) versus Indocyanine green (ICG) fluorescent dye in terms of the overall detection rate and bilateral sentinel lymph node (SLN) mapping in patients with endometrial carcinoma. METHODS: Patients from five European centers with apparently confined clinical stage I endometrial cancer were reviewed. A comparison was made between women who received SLN mapping with pelvic and/or aortic lymphadenectomy (LND), and women who underwent SLN algorithm (SA), was also performed between the two groups...
November 3, 2016: Journal of Cancer Research and Clinical Oncology
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