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Journal of Cancer Research and Clinical Oncology

Hanna Heiman, Christian Keinki, Jutta Huebner
OBJECTIVE: Our aim was to learn more about the association between the sources of information cancer patients and caregivers use and their eHealth literacy. METHODS: We distributed a standardized questionnaire among participants of a lecture program on complementary and alternative medicine (CAM). RESULTS: Among 182 attendants, the Internet was the third most important source of information (57%), preceded by the oncologist (67%) and print media (61%)...
July 13, 2018: Journal of Cancer Research and Clinical Oncology
Jie Yang, Yuan Zhang, Xiaoting Sun, Aaron M Gusdon, Nan Song, Linsong Chen, Gening Jiang, Yueye Huang
PURPOSE: This study aimed to investigate the prognostic value of different organs metastases in patients with non-small cell lung cancer (NSCLC) and its most common subtypes. METHODS: We identified 45,423 NSCLC cases (25,129 men and 20,294 women) between 2010 and 2013 with distant metastases, with complete clinical information obtained from the surveillance, epidemiology, and end results (SEER) database. RESULTS: Bone and liver were the most and the least common metastatic sites with rates of 37...
July 12, 2018: Journal of Cancer Research and Clinical Oncology
David H Murray, Erin L Symonds, Graeme P Young, Susan Byrne, Philippa Rabbitt, Amitesh Roy, Kathryn Cornthwaite, Christos S Karapetis, Susanne K Pedersen
PURPOSE: Methylation in IKZF1 and BCAT1 are common events in colorectal cancer (CRC). They are often detected in blood as circulating tumor DNA (ctDNA) at diagnosis and disappear after surgery in most CRC patients. A prospective study was conducted to determine the relationship between detection of these markers following surgery and risk for residual disease and for recurrence. METHODS: ctDNA status with methylated BCAT1 and IKZF1 was determined within 12 months of surgical resection of CRC, and was related to presence of or risk for residual disease (margins involved, metastases present or nature of node involvement), and to recurrence-free survival...
July 10, 2018: Journal of Cancer Research and Clinical Oncology
Eran Ben-Arye, Hadeel Dahly, Yael Keshet, Jamal Dagash, Noah Samuels
CONTEXT AND OBJECTIVES: To examine the impact of a complementary/integrative medicine (CIM) program on quality of life (QoL)-related concerns among patients scheduled for chemotherapy for breast and gynecologic cancer. METHODS: Chemotherapy-naïve patients were referred by their oncology healthcare professional to an integrative oncology program, where CIM is provided as part of palliative/supportive care. CIM treatments were tailored to patients' preferences and leading concerns, and for most included acupuncture and mind-body-spirit modalities, which were usually co-administered in the week preceding the first chemotherapy cycle...
July 6, 2018: Journal of Cancer Research and Clinical Oncology
Alexey Tryakin, Mikhail Fedyanin, Anatoly Bulanov, Shalva Kashia, Ildar Kurmukov, Vsevolod Matveev, Igor Fainstein, Olga Gordeeva, Tatjana Zakharova, Sergei Tjulandin
PURPOSE: Patients with metastatic nonseminomatous germ cell tumors (mNSGCT) and a high tumor burden or a poor performance status at initial diagnosis are at risk from potentially life-threatening early complications during or after the first chemotherapy cycle. The outcomes with dose-reduced first cycle of chemotherapy in this population of patients are not well established. METHODS: We performed a retrospective analysis of patients with mNSGCT and International Germ Cell Cancer Collaborative Group (IGCCCG) poor risk features...
July 5, 2018: Journal of Cancer Research and Clinical Oncology
Patrick Sven Plum, Dita Ulase, Elfriede Bollschweiler, Seung-Hun Chon, Felix Berlth, Thomas Zander, Hakan Alakus, Arnulf H Hölscher, Christiane J Bruns, Simon Schallenberg, Alexander Quaas, Heike Loeser
PURPOSE: Therapeutic decisions in esophageal adenocarcinomas (EAC) restricted to mucosa (pT1a) or submucosa (pT1b) depend mainly on classic histomorphology-based criteria like tumor grading or lymphovascular invasion with limited success. There is a strong need for reliable pre-therapeutical biomarker-based evaluation also applicable on endoscopically obtained biopsies. METHODS: Patients who underwent esophagectomy due to EAC in a high volume center between 1999 and 2016 were included...
July 4, 2018: Journal of Cancer Research and Clinical Oncology
Hongbin Li, Xiaodong Jin, Bing Chen, Ping Li, Qiang Li
BACKGROUND: Radiotherapy (RT) is one of the most important therapeutic strategies against cancer. However, resistance of cancer cells to radiation remains a major challenge for RT. Thus, novel strategies to overcome cancer cell radioresistance are urgent. Macroautophagy (hereafter referred to as autophagy) is a biological process by which damaged cell components can be removed and accordingly represent a cytoprotective mechanism. Because radiation-induced autophagy is associated with either cell death or radioresistance of cancer cells, a deeper understanding of the autophagy mechanism triggered by radiation will expedite a development of strategies improving the efficacy of RT...
July 3, 2018: Journal of Cancer Research and Clinical Oncology
Silvia Codenotti, Maura Poli, Michela Asperti, Daniela Zizioli, Francesco Marampon, Alessandro Fanzani
PURPOSE: Ferroptosis is a programmed form of iron-dependent cell death caused by lipid hydroperoxide accumulation, which can be prevented by glutathione peroxidase 4 (GPx4) activity. Here we investigated the effects of ferroptosis inducers called erastin and RSL3, which act by glutathione depletion and GPx4 inactivation, respectively, on muscle-derived cell lines of embryonal and alveolar rhabdomyosarcoma (RMS), and mouse normal skeletal C2C12 myoblasts. METHODS: Myogenic lines were exposed to stepwise increasing concentrations of ferroptosis inducers either alone or in combination with iron supplementation, iron chelating agents (bathophenanthrolinedisulfonic acid, BPS), antioxidant molecules (glutathione, N-acetylcysteine), lipid peroxidation inhibitors (ferrostatin-1), and chemotherapeutic agents (doxorubicin and actinomycin D)...
July 3, 2018: Journal of Cancer Research and Clinical Oncology
Yi-Jun Kim, Jae-Sung Kim, In Ah Kim
PURPOSE: To evaluate the impact of molecular subtype on incidence and prognosis of brain metastasis from breast cancer. METHODS: The Surveillance, Epidemiology, and End Results (SEER) 18 registry was used to select breast cancer patients from 2010 to 2014. Molecular subtypes were classified as luminal A (hormone receptor [HR]+/human epidermal growth factor receptor 2 [HER2]-), luminal B (HR+/HER2+), HER2 (HR-/HER2+), or triple negative breast cancer (TNBC) (HR-/HER2-)...
July 3, 2018: Journal of Cancer Research and Clinical Oncology
M Isabel Gonzaga, Leah Grant, Christina Curtin, Jonathan Gootee, Peter Silberstein, Elida Voth
PURPOSE: Clear cell sarcoma (CCS) is a rare soft tissue tumor thought to originate from tendons and aponeuroses. This is the largest and most comprehensive study of CCS to the best of our knowledge. In addition, this is the first study to determine the estimated 10-year overall survival, specific treatment modalities including neoadjuvant and adjuvant combinations, and sites of distant metastasis in CCS utilizing a national database. METHODS: The National Cancer Database (NCDB) was used to study 489 patients diagnosed with CCS from 2004 to 2014...
June 30, 2018: Journal of Cancer Research and Clinical Oncology
Sebastien Rinaldetti, Ralph Wirtz, Thomas Stefan Worst, Arndt Hartmann, Johannes Breyer, Lars Dyrskjot, Philipp Erben
PURPOSE: The proto-oncogene forkhead box M1 (FOXM1) is associated with poor survival in many cancers. The impact of FOXM1 expression on progression-free survival (PFS) of non-muscle invasive bladder cancer (NMIBC) has not yet been investigated. The differential expression of FOXM1 between the different molecular NMIBC subtypes has further been assessed. METHODS: Transcript levels of FOXM1 and MKI67 were determined in 460 NMIBC patients (UROMOL cohort) by RNA-Seq and validated in silico by the Chungbuk and Lund cohort (n = 277)...
June 29, 2018: Journal of Cancer Research and Clinical Oncology
Carmela Ciccarelli, Agnese Di Rocco, Giovanni Luca Gravina, Annunziata Mauro, Claudio Festuccia, Andrea Del Fattore, Paolo Berardinelli, Francesca De Felice, Daniela Musio, Marina Bouché, Vincenzo Tombolini, Bianca Maria Zani, Francesco Marampon
PURPOSE: Prostate cancer (PCa) cell radioresistance causes the failure of radiation therapy (RT) in localized or locally advanced disease. The aberrant accumulation of c-Myc oncoprotein, known to promote PCa onset and progression, may be due to the control of gene transcription and/or MEK/ERK-regulated protein stabilization. Here, we investigated the role of MEK/ERK signaling in PCa. METHODS: LnCAP, 22Rv1, DU145, and PC3 PCa cell lines were used in in vitro and in vivo experiments...
June 29, 2018: Journal of Cancer Research and Clinical Oncology
Sarah Besora, Cristina Santos, Cristina Izquierdo, Maria Mercedes Martinez-Villacampa, Jordi Bruna, Roser Velasco
BACKGROUND: Oxaliplatin (OXA) is a cornerstone in the treatment of colorectal cancer (CRC). Retreatment with OXA is frequently considered as salvage treatment. OXA-induced neuropathy (OIN) is the most frequent and feared long-term side effect. PATIENTS AND METHODS: CRC patients receiving at least twice OXA-based chemotherapy lines at our institution between June 2000 and July 2016 were reviewed. The aim of this study was to investigate whether retreatment with OXA increases the risk of developing new or worsening previous neuropathy...
June 28, 2018: Journal of Cancer Research and Clinical Oncology
Paul Lennart Vollmers, Christoph Mundhenke, Nicolai Maass, Dirk Bauerschlag, Stefan Kratzenstein, Christoph Röcken, Thorsten Schmidt
INTRODUCTION: Breast cancer is the most common cancer disease of women in industrialized countries. Neurotoxic chemotherapy drugs are known to harm peripheral nerves and cause a chemotherapy-induced peripheral neuropathy (CIPN). CIPN is one of the most common adverse events associated with Paclitaxel chemotherapy and may remain present long after the termination of chemotherapy. Thus, it reduces the patients' quality of life (QoL) both during chemotherapy and onwards, and can impose a danger on breast cancer survivors due to an increased risk of falling and fall-related injuries...
June 25, 2018: Journal of Cancer Research and Clinical Oncology
Ciro Franzese, Tiziana Comito, Elena Clerici, Lucia Di Brina, Stefano Tomatis, Pierina Navarria, Giacomo Reggiori, Luca Viganò, Dario Poretti, Vittorio Pedicini, Guido Torzilli, Luigi Solbiati, Marta Scorsetti
PURPOSE: The study aim was to compare the disease control in two groups of patients affected by liver metastases from CRC treated with microwave ablation (MWA) or stereotactic body radiation therapy (SBRT). METHODS: We extracted data of patients treated between 2009 and 2016. Inclusion criteria were: (1) maximum diameter of the liver lesions less than 4 cm; (2) no more than three liver lesions; (3) no evidence of progressive or untreated gross disease outside the liver; (4) adequate liver function; (5) no concurrent chemotherapy; (6) minimum age of 18...
June 22, 2018: Journal of Cancer Research and Clinical Oncology
Labrinus van Manen, Jouke Dijkstra, Claude Boccara, Emilie Benoit, Alexander L Vahrmeijer, Michalina J Gora, J Sven D Mieog
INTRODUCTION: Tumor detection and visualization plays a key role in the clinical workflow of a patient with suspected cancer, both in the diagnosis and treatment. Several optical imaging techniques have been evaluated for guidance during oncological interventions. Optical coherence tomography (OCT) is a technique which has been widely evaluated during the past decades. This review aims to determine the clinical usefulness of OCT during cancer interventions focussing on qualitative features, quantitative features and the diagnostic value of OCT...
June 20, 2018: Journal of Cancer Research and Clinical Oncology
Dominika Piasecka, Marcin Braun, Radzislaw Kordek, Rafal Sadej, Hanna Romanska
PURPOSE: Dysregulation of miRNA profile has been associated with a broad spectrum of cellular processes underlying progression of various human malignancies. Increasing evidence suggests that specific microRNA clusters might be of clinical utility, especially in triple-negative breast carcinoma (TNBC), devoid of both predictive markers and potential therapeutic targets. Here we provide a comprehensive review of the existing data on microRNAs in TNBC, their molecular targets, a putative role in invasive progression with a particular emphasis on the epithelial-to-mesenchymal transition (EMT) and acquisition of stem-cell properties (CSC), regarded both as prerequisites for metastasis, and significance for therapy...
June 19, 2018: Journal of Cancer Research and Clinical Oncology
Claire M B Holloway, Li Jiang, Marlo Whitehead, Jennifer M Racz, Patti A Groome
PURPOSE: Mortality reduction attributable to organized breast screening is modest. Screening may be less effective at detecting more aggressive cancers at an earlier stage. This study was conducted to determine the relative efficacy of screening mammography to detect cancers at an earlier stage by molecular phenotype. METHODS: We identified 2882 women with primary invasive breast cancer diagnosed between January 1, 2008 and December 31, 2012 and who had a mammogram through the Ontario Breast Screening Program in the 28 months before diagnosis...
June 16, 2018: Journal of Cancer Research and Clinical Oncology
Seung-Ryeol Lee, Young-Deuk Choi, Nam-Hoon Cho
PURPOSE: To evaluate associations between pathologic factors and erythroblast transformation-specific (ETS)-related gene (ERG) expression in prostate cancer patients. Using next-generation sequencing, we identified target genes and regulatory networks. METHODS: ERG expression in 60 radical prostatectomies was compared with pathological findings by association rule mining with the Apriori algorithm. Whole-exome and RNA sequencing were performed on three formalin-fixed, paraffin-embedded ERG-positive and negative prostate cancer samples...
June 12, 2018: Journal of Cancer Research and Clinical Oncology
Hea Nam Hong, You Jin Won, Ju Hee Shim, Hyun Ji Kim, Seung Hee Han, Byung Sik Kim, Hee Sung Kim
PURPOSE: Under physiologic conditions, the binding of erythropoietin-producing hepatocellular (Eph) A2 receptor and its ligand ephrinA1 results in decreased EphA2 level and tumor suppression. However, EphA2 and ephrinA1 are highly expressed in human cancers including gastric adenocarcinoma. In this study, we tested our hypothesis that cancer-associated fibroblasts (CAFs) promote gastric tumorigenesis through EphA2 signaling in a ligand-independent manner. METHODS: Expression of EphA2 protein in primary tumor tissues of 91 patients who underwent curative surgery for gastric adenocarcinoma was evaluated by immunohistochemistry and western blotting...
June 12, 2018: Journal of Cancer Research and Clinical Oncology
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