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American Journal of Chinese Medicine

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https://www.readbyqxmd.com/read/28922926/acupuncture-plus-herbal-medicine-for-alzheimer-s-disease-a-systematic-review-and-meta-analysis
#1
Simin Zhou, Lanlan Dong, Yuan He, Hong Xiao
Alzheimer's disease (AD) is associated with the unprecedented aging tendency in our world population and has become a significant health issue. The use of Traditional Chinese Medicine to treat AD has been increasing in recent years. The objective of this meta-analysis is to evaluate the effectiveness of combining acupuncture with herbal medicine to treat AD. Randomized controlled trials (RCTs) of acupuncture plus herbals versus treatment with western drugs for AD were retrieved from 11 databases. The data were extracted by two authors; dichotomous data were expressed as odds ratio (ORs) and 95% confidence intervals (CIs), while continuous data were calculated by mean differences (MDs) with 95% CIs...
September 18, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28830215/a-systematic-review-and-meta-analysis-of-acupressure-for-postoperative-gastrointestinal-symptoms-among-abdominal-surgery-patients
#2
Yunhong Liu, Winnie P Y Tang, Shengxiang Gong, Carmen W H Chan
Postoperative ileus is a common and often life-threatening gastrointestinal complication with few management methods available for patients. Integrating acupressure into perioperative care promises to bring benefits into preventing postoperative ileus. This systematic review and meta-analysis aims to evaluate the efficacy of acupressure in identifying the signs and symptoms of postoperative ileus among patients undergoing abdominal surgery. The MEDLINE, EMBASE, Web of Science, CINAHL, China Journal Net and Wanfang databases were searched for high-quality RCTs using keywords such as acupressure, postoperative ileus, abdominal surgery, etc...
August 22, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28830214/anti-inflammatory-and-immunostimulatory-activities-of-astragalosides
#3
Yan Qi, Feng Gao, Lifei Hou, Chunping Wan
Astragalus membranaceus (Fisch) Bge(Huang-Qi) is a well-known herbal medicine with tonic property and has been widely used to treat cancer and other immune disorders in China and Southeast Asia for thousands of years. Accumulating evidence suggests that Huang-Qi possesses both immune-boosting and anti-inflammatory/immune-regulatory effects clinically, leaving the mechanism elusive. Recently, we discovered that Astragaloside (ASI), a major active component of Huang-Qi, is able to increase CD45 phosphatase activity...
August 22, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28830213/syk-mediated-suppression-of-inflammatory-responses-by-cordyceps-bassiana
#4
Woo Seok Yang, Gyeong Sug Nam, Mi-Yeon Kim, Jae Youl Cho
The fruit body of artificially cultivated Cordyceps bassiana has been reported to exhibit anti-inflammatory and anticancer activities. Although it has been suggested that the fruit body has neutraceutic and pharmaceutic biomaterial potential, the exact anti-inflammatory molecular mechanism has not been fully elucidated. In this study, we demonstrated the immunopharmacologic activity of Cordyceps bassiana under in vitro conditions and investigated its anti-inflammatory mechanism. Water extract (Cm-WE) of the fruit body of artificially cultivated Cordyceps bassiana without polysaccharide fractions reduced the expression of the proinflammatory genes cyclooxygenase (COX)-2, interleukin (IL)-12, and inducible nitric oxide synthase (iNOS) and promoted the expression of the anti-inflammatory gene IL-10 in lipopolysaccharide (LPS)-treated RAW264...
August 22, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28830212/heat-processed-scutellariae-radix-protects-hepatic-inflammation-through-the-amelioration-of-oxidative-stress-in-lipopolysaccharide-induced-mice
#5
Chan Hum Park, Mi-Rae Shin, Byung Kwan An, Hyun Woo Joh, Jang Cheon Lee, Seong-Soo Roh, Takako Yokozawa
The present study evaluated the effects of heat-processed Scutellariae Radix (Scutellaria baicalensis) on lipopolysaccharide (LPS)-induced liver injury in mice. Scutellariae Radix heat-processed at 160[Formula: see text]C or 180[Formula: see text]C was orally administered at a dose of 100 mg/kg body weight for three days before the intraperitoneal injection of LPS, and the effects were compared with those of vehicle-treated LPS administered to control mice. The administration of Scutellariae Radix decreased the elevated serum monocyte chemotactic protein-1 (MCP-1), interleukin-6 (IL-6), reactive oxygen species (ROS), nitrite/nitrate, peroxynitrite, and hepatic functional parameters, and reduced the increased ROS in the liver...
August 22, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28830211/rhodiola-crenulata-attenuates-high-glucose-induced-endothelial-dysfunction-in-human-umbilical-vein-endothelial-cells
#6
Li-Yen Huang, I-Chuan Yen, Wei-Cheng Tsai, Blerina Ahmetaj-Shala, Tsu-Chung Chang, Chien-Sung Tsai, Shih-Yu Lee
Rhodiola crenulata root extract (RCE), a traditional Chinese medicine, has been shown to regulate glucose and lipid metabolism via the AMPK pathway in high glucose (HG) conditions. However, the effect of RCE on HG-induced endothelial dysfunction remains unclear. The present study was designed to examine the effects and mechanisms of RCE against hyperglycemic insult in endothelial cells. Human umbilical vein endothelial cells (HUVECs) were pretreated with or without RCE and then exposed to 33[Formula: see text]mM HG medium...
August 22, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28830210/arctii-fructus-inhibits-colorectal-cancer-cell-proliferation-and-mmps-mediated-invasion-via-ampk
#7
Yo-Han Han, Ji-Ye Kee, Dae-Seung Kim, Jeong-Geon Mun, Seong-Hwan Park, Yong Ju Kim, Jae-Young Um, Seung-Heon Hong
Although Arctii Fructus (AF) has been shown to have various pharmacological effects, there have been no studies concerning the inhibitory effects of AF on the metastatic properties of colorectal cancer (CRC). The aim of this study was to investigate whether AF could suppress CRC progression by inhibiting cell growth, epithelial-mesenchymal transition (EMT), migration, and the invasion ability of CRC cells. AF decreased proliferation of CRC cells by inducing cell cycle arrest and apoptosis via extrinsic and intrinsic apoptotic pathways...
August 22, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28830209/puerarin-improves-vascular-insulin-resistance-and-cardiovascular-remodeling-in-salt-sensitive-hypertension
#8
Chunxiang Tan, Aimei Wang, Chan Liu, Yao Li, Yuepin Shi, Ming-Sheng Zhou
Puerarin is an isoflavonoid isolated from the Chinese herb, Kudzu roots (also known as Gegen), which has been widely used for the treatment of hypertensive diseases and diabetic mellitus in traditional Chinese medicine. Dahl salt-sensitive (DS) rat is a genetic model of salt-sensitive hypertension with cardiovascular injury and vascular insulin resistance. Here, we investigated whether puerarin improved vascular insulin resistance and attenuated cardiac and aortic remodeling in salt-sensitive hypertension. DS rats were given a normal (NS) or high salt diet (HS) for five weeks...
August 22, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28830207/ginseng-on-nuclear-hormone-receptors
#9
Joonwoo Park, Phuong T C Bui, Heewon Song, Si-Kwan Kim, Dong-Kwon Rhee, Eun-Young Kim, Mee-Ra Rhyu, Myeong Soo Lee, Young Joo Lee
The first record of ginseng use dates back over two millennia, and ginseng is now popular in more than 35 countries. Ginsenosides are the pharmacological constituents responsible for the beneficial effects of ginseng. There is increasing evidence that ginseng and its bioactive ingredients are involved in the regulation of nuclear receptors, molecules that act in response to the specific binding of hormones, which link to a diverse array of signaling pathways, such as the ERK and PI3K/Akt pathways. Knowledge of the mechanism of how ginseng mediates these complexes is essential for the development of multi-target phytomedicine as possible therapy for different diseases...
August 22, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28830206/sulforaphane-reduces-hmgb1-mediated-septic-responses-and-improves-survival-rate-in-septic-mice
#10
In-Chul Lee, Dae Yong Kim, Jong-Sup Bae
Sulforaphane (SFN), a natural isothiocyanate present in cruciferous vegetables such as broccoli and cabbage, is effective in preventing carcinogenesis, diabetes, and inflammatory responses. Inhibition of high mobility group box 1 (HMGB1) and restoration of endothelial integrity is emerging as an attractive therapeutic strategy in the management of severe sepsis or septic shock. In this study, we examined the effects of SFN on HMGB1-mediated septic responses and survival rate in a mouse sepsis model. The anti-inflammatory activities of SFN were monitored based on its effects on lipopolysaccharide (LPS)- or cecal ligation and puncture (CLP)-mediated release of HMGB1...
August 22, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28659035/geraniin-promotes-recovery-of-hematopoietic-cells-after-radiation-injury
#11
So Jin Bing, Jinhee Cho, Areum Kim, Kalahe Hewage Iresha Nadeeka Madushani Herath, Ginnae Ahn, Nam Ho Lee, Jae Woo Park, Youngheun Jee
Cells of the hematopoietic system are uniquely radiosensitive due to their rapid proliferation. Consequently, immune suppression readily and undesirably results from irradiation. Our previous studies demonstrated that geraniin isolated from Nymphaea tetragona var. angusta (water lily) had a protective effect on the splenocytes and intestinal tract of irradiated mice. This study was designed to assess the effectiveness of geraniin, an ellagitannin isolated from the water lily, in decreasing gamma ray irradiation-induced destruction of the hematopoietic system in mice...
June 28, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28659034/a-review-on-annona-squamosa-l-phytochemicals-and-biological-activities
#12
Chengyao Ma, Yayun Chen, Jianwei Chen, Xiang Li, Yong Chen
Annona squamosa L. (Annonaceae) is a fruit tree with a long history of traditional uses. A. squamosa is an evergreen plant mainly located in tropical and subtropical regions. Srikayas, the fruits of A. squamosa, are extensively used to prepare candies, ice creams and beverages. A wide range of ethno-medicinal uses has been related to different portions of A. squamosa, such as tonic, apophlegmatisant, cool medicine, abortient and heart sedative. Numerous research projects on A. squamosa have found that it has anticancer, anti-oxidant, antidiabetic, antihypertensive, hepatoprotective, antiparasitic, antimalarial, insecticidal, microbicidel and molluscicidal activities...
June 28, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28659032/epimedin-c-promotes-vascularization-during-bmp2-induced-osteogenesis-and-tumor-associated-angiogenesis
#13
Yan-Mei Shui, Gui-Yuan Lv, Le-Tian Shan, Chun-Lei Fan, Nan Tian, Li Zhang, Tong-Chuan He, Jian-Li Gao
Epimedin C is one of the chemical markers and major flavonoids in Herba Epimedii (Yinyanghuo), which is traditionally used to treat bone diseases and gonadal dysfunction in China. Our previous study indicated that epimedin C could induce endothelial-like, but not osteogenic differentiation of C3H/10T1/2 cells in vitro. As vasculogenesis plays a pivotal role in bone formation, this study used the bone morphogenetic protein 2 (BMP2) induced ectopic bone formation model and mice 4T1 breast cancer cells co-implanted with luciferase labeled C3H/10T1/2 cells (4T1 [Formula: see text] C3H/10T1/2-Luc) model to examine the in vivo effects of Epimedin C on vasculogenesis...
June 28, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28659031/gypenosides-ameliorate-carbon-tetrachloride-induced-liver-fibrosis-by-inhibiting-the-differentiation-of-hepatic-progenitor-cells-into-myofibroblasts
#14
Jiamei Chen, Xuewei Li, Yonghong Hu, Wei Liu, Qun Zhou, Hua Zhang, Yongping Mu, Ping Liu
Gypenosides (GPs), the predominant components of Gynostemma pentaphyllum, exert antifibrotic effects; however, the mechanisms underlying their ability to ameliorate liver fibrosis are unclear. Liver fibrosis was induced in C57BL/6 mice via subcutaneous injection of 10% carbon tetrachloride (CCl[Formula: see text] three times a week for two weeks. Then, CCl4 was administered in conjunction with intragastric GPs for another three weeks. For in vitro analyses, WB-F344, hepatatic progenitor cells (HPCs) were treated with transforming growth factor beta 1 (TGF-β1) with or without GPs for 48[Formula: see text]h...
June 28, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28659030/tongxinluo-inhibits-renal-fibrosis-in-diabetic-nephropathy-involvement-of-the-suppression-of-intercellular-transfer-of-tgf-formula-see-text-1-containing-exosomes-from-gecs-to-gmcs
#15
Xiao-Ming Wu, Yan-Bin Gao, Li-Ping Xu, Da-Wei Zou, Zhi-Yao Zhu, Xiao-Lei Wang, Wei-Jie Yao, Liang-Tao Luo, Yu Tong, Nian-Xiu Tian, Zhe-Ji Han, Wan-Yu Dang
Glomerular mesangial cells (GMCs) activation is implicated in the pathogenesis of diabetic nephropathy (DN). Our previous study revealed that high glucose (HG)-treated glomerular endothelial cells (GECs) produce an increased number of TGF-β1-containing exosomes to activate GMCs through the TGF-β1/Smad3 signaling pathway. We also identified that Tongxinluo (TXL), a traditional Chinese medicine, has beneficial effects on the treatment of DN in DN patients and type 2 diabetic mice. However, it remained elusive whether TXL could ameliorate renal structure and function through suppression of intercellular transfer of TGF-β1-containing exosomes from GECs to GMCs...
June 28, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28659029/the-mixture-of-anemarrhena-asphodeloides-and-coptis-chinensis-attenuates-high-fat-diet-induced-colitis-in-mice
#16
Su-Min Lim, Hyun-Sik Choi, Dong-Hyun Kim
Anemarrhena asphodeloides (AA, family Liliaceae) inhibits macrophage activation by inhibiting IRAK1 phosphorylation and helper T (Th)17 differentiation. Coptis chinensis (CC, family Ranunculaceae), which inhibits macrophage activation by inhibiting the binding of lipopolysaccharide (LPS) on toll-like receptor 4 and inducing regulatory T (Treg) cell differentiation. The mixture of AA and CC (AC-mix) synergistically attenuates 2,4,6-trinitrobenzenesulfonic acid or dextran sulfate sodium-induced colitis in mice by inhibiting NF-[Formula: see text]B activation and regulating Th17/Treg balance...
June 28, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28659028/efficacy-and-mechanisms-of-chinese-medicine-on-the-modulation-of-myocardial-autophagy-in-cardiovascular-disease
#17
Yue-Ying Li, Yong-Hua Zhao
Autophagy refers to the process in which the cellular lysosome degrades the cell's own damaged organelles and related macromolecule substances. It plays important roles in the homeostasis of organs, cell survival, and stable development. Previous studies indicate that the process of cardiopathology is closely associated with autophagy and some of Chinese medicines (active compounds and formulae) are found to have beneficial effects on injured cardiomyocytes via the modulation of autophagy. This review highlights the efficacy of the action of Chinese medicine on the regulation of myocardial autophagy and summarizes the related molecular and signal mechanisms...
June 28, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28659027/eclipta-prostrata-improves-dss-induced-colitis-through-regulation-of-inflammatory-response-in-intestinal-epithelial-cells
#18
Dae-Seung Kim, Sung-Hee Kim, Ji-Ye Kee, Yo-Han Han, JinBong Park, Jeong-Geon Mun, Moon-Jung Joo, Yong-Deok Jeon, Su-Jin Kim, Sang-Hyun Park, Sung-Joo Park, Jae-Young Um, Seung-Heon Hong
Eclipta prostrata (EP) and its compounds are known to have several pharmacological effects including anti-inflammatory effects. In the present study, we demonstrated that EP improves the dextran sulfate sodium (DSS)-induced colitis symptoms such as body weight loss, colon length shortening and disease activity index. In DSS-induced colitis tissue, EP controls the protein expressions of cyclooxygenase-2 (COX-2) and hypoxia inducible factor-1[Formula: see text] (HIF-1[Formula: see text]). In addition, the release of prostaglandin E2 and vascular endothelial growth factor-A were significantly reduced by EP administration...
June 28, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28893092/salvianolic-acid-a-a-component-of-salvia-miltiorrhiza-attenuates-endothelial-mesenchymal-transition-of-hpaecs-induced-by-hypoxia
#19
Tianyi Yuan, Yucai Chen, Huifang Zhang, Lianhua Fang, Guanhua Du
Salvianolic acid A (SAA), a polyphenols acid, is a bioactive ingredient from a traditional Chinese medicine called Dan shen (Salvia Miltiorrhiza Bunge). According to previous studies, it was shown to have various effects such as anti-oxidative stress, antidiabetic complications and antipulmonary hypertension. This study aimed to investigate the effect of SAA on pulmonary arterial endothelial-mesenchymal transition (EndoMT) induced by hypoxia and the underlying mechanisms. Primary cultured human pulmonary arterial endothelial cells (HPAECs) were exposed to 1% O2 for 48[Formula: see text]h with or without SAA treatment...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28893091/lutein-induces-autophagy-via-beclin-1-upregulation-in-iec-6-rat-intestinal-epithelial-cells
#20
Chi-Jen Chang, Ji-Fan Lin, Chien-Yu Hsiao, Hsun-Hao Chang, Hsin-Ju Li, Hsun-Hsien Chang, Gon-Ann Lee, Chi-Feng Hung
Lutein is a carotenoid with anti-oxidant properties. Autophagy, an evolutionarily conserved catabolic cellular pathway for coping with stress conditions, is responsive to reactive oxygen species (ROS) and degrades damaged organelles. We previously demonstrated that lutein can induce anti-oxidant enzymes to relieve methotrexate-induced ROS stress. We therefore hypothesized that lutein, which activates ROS-scavenging enzymes, can also induce autophagy for cell survival. In this study, we demonstrated that lutein treatment attenuated the reduction in cell viability caused by H2O2...
2017: American Journal of Chinese Medicine
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