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American Journal of Chinese Medicine

Zefeng Zhao, Xirui He, Qiang Zhang, Xiaoyang Wei, Linhong Huang, Jia Cheng Fang, Xiaoxiao Wang, Meimei Zhao, Yajun Bai, Xiaohui Zheng
Plants from the genus Sanguisorba have been treated as medicinal ingredients for over 2000 years. This paper reviews advances in the botanical, phytochemical and pharmacological studies of the genus. To date, more than 120 chemical constituents have been isolated and identified from these plants, especially from S. officinalis and S. minor. Among these compounds, triterpenoids, phenols and flavonoids are the primary biologically active constituents. Triterpenoids can be used as quality control markers to determine the quality of medicinal materials and their preparations...
March 2, 2017: American Journal of Chinese Medicine
San Fu, Yanfang Yang, Dan Liu, Yan Luo, Xiaochuan Ye, Yanwen Liu, Xin Chen, Song Wang, Hezhen Wu, Yuhang Wang, Qiwei Hu, Pengtao You
In vitro evidence indicates that Smilax china L. rhizome (SCR) can inhibit cell proliferation. Therefore, in the present study, we analyzed the effects in vitro of SCR extracts on human lung adenocarcinoma A549 cells. Our results showed that A549 cell growth was inhibited in a dose- and time-dependent manner after treatment with SCR extracts. Total flavonoids and total tannins from SCR induced A549 apoptosis in a dose-dependent manner, as shown by our flow cytometry analysis, which was consistent with the alterations in nuclear morphology we observed...
February 23, 2017: American Journal of Chinese Medicine
Hsin-Shun Tseng, Yu-Fen Wang, Yew-Min Tzeng, Dar-Ren Chen, Ya-Fan Liao, Hui-Yu Chiu, Wen-Tsong Hsieh
Aloe-emodin (AE) is derived from Aloe vera and rhubarb (Rheum palmatum) and exhibits anticancer activities via multiple regulatory mechanisms in various cancers. AE can also enhance the anticancer efficacy of cisplatin, doxorubicin, docetaxel, and 5-fluorouracil; however, its effects remain poorly characterized. MCF-7, MDA-MB-231, MDA-MB-468, BT-474, and HCC-1954 breast cancer cell lines were treated with the indicated conditions of AE, and cell viability assays were performed. The expression levels of signaling proteins were determined by western blot analysis, intracellular reactive oxygen species (ROS), cell cycle distributions, and rates of apoptosis as estimated by flow cytometry...
February 23, 2017: American Journal of Chinese Medicine
Chang-Han Chen, Ming-Feng Chen, S Joseph Huang, Chun-Yen Huang, Hao-Kuang Wang, Wen-Chuan Hsieh, Chih-Hao Huang, Li-Feng Liu, Li-Yen Shiu
Saikosaponin a (SSa) is one of the main active components of Bupleurum falcatum. It is commonly used to treat liver injury and fibrosis in traditional Chinese medicine. Our previous study showed that SSa induces apoptosis and inhibits the proliferation of rat hepatic stellate cell (HSC) line HSC-T6. The aim of the present study was to elucidate the mechanism of SSa-mediated apoptosis. Rat HSC cell line HSC-T6 and human HSC cell line LX-2 were used in this study. SSa triggered cell death mainly by apoptosis, as indicated by the typical morphological changes, sub-G1 phase of cell cycle increase, and activation of the caspase-9/caspase-3 cascade...
February 23, 2017: American Journal of Chinese Medicine
Sijia Fang, Miao Wang, Yiyuan Zheng, Shigao Zhou, Guang Ji
Obesity is an epidemic health hazard associated with many medical conditions. Lifestyle interventions are foundational to the successful management of obesity. However, the body's adaptive biological responses counteract patients' desire to restrict food and energy intake, leading to weight regain. As a complementary and alternative medical approach, acupuncture therapy is widely used for weight control. The objective of this study was to assess the efficacy of acupuncture treatment alone and in combination with lifestyle modification...
February 23, 2017: American Journal of Chinese Medicine
Na-Hyung Kim, Ming Jie Xin, Ji-Yoon Cha, Soo-Jeong Ji, Se-Uk Kwon, Ho-Kyun Jee, Mi-Ran Park, Yong-Soo Park, Chong-Tai Kim, Dae-Ki Kim, Young-Mi Lee
Gastrodia elata Blume (GE) is a well-known kind of herb that has been used in traditional medicine for thousands of years. The extrusion of raw materials from it could improve flavor and enhance bioavailability in food and drug development. The purpose of this study is to investigate antitumor and immune boosting effects of extruded GE in human colon carcinoma cells, splenocytes, and mice-bearing CT26 colon carcinoma cell. Treatment with 100[Formula: see text][Formula: see text]g/mL of extruded GE decreased cell viability and induced the expression of Caspase-3 and Bax in HT29 cells ([Formula: see text])...
February 23, 2017: American Journal of Chinese Medicine
Yen-Nung Liao, Wen-Long Hu, Hsuan-Ju Chen, Yu-Chiang Hung
In Oriental countries, combinations of Chinese herbal products (CHPs) are often utilized as therapeutic agents for chronic obstructive pulmonary disease (COPD). The effects of CHPs on COPD have been previously reported. This study aimed to analyze the frequency of prescription and usage of CHPs in patients with COPD in Taiwan. In this nationwide population-based cross-sectional study, 19,142 patients from a random sample of one million individuals in the Longitudinal Health Insurance Database 2000 (LHID 2000) of the National Health Insurance Research Database (NHIRD) were enrolled from 2000 to 2011...
February 23, 2017: American Journal of Chinese Medicine
Tae Won Rho, Seo Young Lee, Sang-Yong Han, Ji Hoon Kim, Kyung-Hee Lee, Dong-Seon Kim, Han Bok Kwak, Yun-Kyung Kim
Osteoporosis results from imbalance between new bone formation and bone resorption leading to bone loss and is especially troublesome for postmenopausal women who suffer from estrogen deficiency. The ability of new therapeutic agents to treat this bone disease with minimal side effects has been extensively reported on and is continuously being sought out by researchers in this field. Thus, the purpose of this study was to investigate a natural herb that was already being used as a new treatment for osteoporosis...
February 23, 2017: American Journal of Chinese Medicine
Ling Jin, Meng Xu, Xue-Hua Luo, Xiao-Feng Zhu
Chinese Herbal Formulation, supplement energy and nourish lung (SENL), effectively enhances chemotherapeutic efficacy in lung cancer treatment and reverses multi-drug resistance (MDR) in lung cancer cells in vitro. The present study is designed to assess the effect of a New SENL (NSENL, modification of SENL) formulation on resistance to chemotherapy of cisplatin (DDP)-resistant human lung cancer cell line (A549/DDP) xenografts in nude mice. We assessed six constituents in NSENL by high performance liquid chromatography (HPLC)...
February 23, 2017: American Journal of Chinese Medicine
Ya Wen Chiang, Chia Feng Yeh, Ming Hong Yen, Chi Yu Lu, Lien Chai Chiang, Den En Shieh, Jung San Chang
Enterovirus 71 (EV71) infection can cause airway symptoms, brainstem encephalitis, neurogenic shock, and neurogenic pulmonary edema with high morbidity and mortality. There is no proven therapeutic modality. Flos Farfarae is the dried flower bud of Tussilago farfara L. that has been used to manage airway illnesses for thousands of years. It has neuro-protective activity and has been used to manage neuro-inflammatory diseases. However, it is unknown whether Flos Farfarae has activity against EV71-induced neuropathy...
February 23, 2017: American Journal of Chinese Medicine
Jun Matsumoto-Miyazaki, Hiroaki Ushikoshi, Shusaku Miyata, Nagisa Miyazaki, Takahide Nawa, Hideshi Okada, Shinsuke Ojio, Shinji Ogura, Shinya Minatoguchi
The aim of this study was to determine the effect of combination therapy consisting of acupuncture and traditional herbal medicine (Kampo medicine) for reducing the incidence rate of delirium in patients with cardiovascular (CV) disease in ICUs. Twenty-nine patients who had been urgently admitted to the ICU in the control period were treated with conventional intensive care. Thirty patients in the treatment period received conventional therapy plus a combination therapy consisting of acupuncture and herbal medicine...
February 23, 2017: American Journal of Chinese Medicine
Mi Hye Kim, Eun-Jung Kim, You Yeon Choi, Jongki Hong, Woong Mo Yang
The fruit of Lycium chinense Miller (Solanaceae) is used as a functional food and a medicinal herb for treating many specific health concerns. Weight gain induced by estrogen deficiency is a problem for post-menopausal women around the globe. The present study investigates the effects of aqueous extract of L. chinense (LC) on post-menopausal obesity. Female C57BL/6 mice were ovariectomized and fed on high-fat diet (HFD) for 12 weeks to induce post-menopausal obesity. LC extract (1[Formula: see text]mg/kg and 10[Formula: see text]mg/kg) was orally administrated for 6 weeks with continuous HFD feeding...
February 23, 2017: American Journal of Chinese Medicine
Chiung-Huei Peng, Mon-Yuan Yang, Yi-Sun Yang, Chieh-Chou Yu, Chau-Jong Wang
Antrodia cinnamomea (AC), a protogenic fungus that only grows on the heartwood of endemic Cinnamomum kanehirae Hayata in Taiwan, is used to treat a variety of illness including liver disease. However, little is known about the benefit of AC against obesity and the related hepatic disorder. Using high-fat-diet (HFD) feed mice, we aimed to investigate whether the extract of AC (ACE) could reduce excessive weight, body fat, and serum lipids and prevent the development of non-alcoholic fatty liver (NAFLD). C57BL/6 mice were divided into five groups fed with different diets: control, HFD, and HFD with 0...
2017: American Journal of Chinese Medicine
Chia-Chih Liao, Yuan-Ji Day, Hung-Chen Lee, Jiin-Tarng Liou, An-Hsun Chou, Fu-Chao Liu
Acetaminophen (APAP) overdose causes hepatocytes necrosis and acute liver failure. Baicalin (BA), a major flavonoid of Scutellariae radix, has potent hepatoprotective properties in traditional medicine. In the present study, we investigated the protective effects of BA on a APAP-induced liver injury in a mouse model. The mice received an intraperitoneal hepatotoxic dose of APAP (300[Formula: see text]mg/kg) and after 30[Formula: see text]min, were treated with BA at concentrations of 0, 15, 30, or 60[Formula: see text]mg/kg...
2017: American Journal of Chinese Medicine
Ya-Fang Wang, Yu-Lian Xu, Zheng-Hai Tang, Ting Li, Le-Le Zhang, Xiuping Chen, Jia-Hong Lu, Chung-Hang Leung, Dik-Lung Ma, Wen-An Qiang, Yi-Tao Wang, Jin-Jian Lu
Baicalein (BA), one of the major compounds isolated from the root of Scutellaria baicalensis Gerogi, exhibits various pharmacological effects, such as anti-oxidant, anti-inflammatory, and anticancer effects. In this study, we found that BA reduced cell viability and increased apoptosis in ovarian cancer cells. Treatment of cells with BA enhanced microtubule-associated protein light chain 3-II (LC3-II) expression, acidic vesicular organelle and GFP-LC3 fluorescence dot accumulation. Combined treatment with chloroquine and BA apparently reduced cell viability and increased the cleavage of poly (ADPribose) polymerase (PARP) in both HEY and A2780 ovarian cancer cell lines, indicating that BA induces a protective autophagy in these cells...
2017: American Journal of Chinese Medicine
Xiao Zhang, Ying Xu, Jia-Mei Chen, Cheng Liu, Guang-Li Du, Hua Zhang, Gao-Feng Chen, Shi-Li Jiang, Cheng-Hai Liu, Yong-Ping Mu, Ping Liu
Notch signaling has been demonstrated to be involved in ductular reactions and fibrosis. Previous studies have shown that Huang Qi Decoction (HQD) can prevent the progression of cholestatic liver fibrosis (CLF). However, whether HQD affects the Notch signaling pathway is unclear. In this study, CLF was established by common bile duct ligation (BDL) in rats. At the end of the first week, the rats were randomly divided into a model group (i.e., BDL), an HQD group, and a sorafenib positive control group (SORA) and were treated for 3 weeks...
2017: American Journal of Chinese Medicine
Mingge Ding, Yin Wang, Di Sun, Zhenghua Liu, Jie Wang, Xing Li, Cong Huo, Xin Jia, Wei Chen, Feng Fu, Xiaoming Wang
Punicalagin (PUN), a major bioactive component in pomegranate juice, has been proven to exert neuroprotective effects against cerebral ischemia/reperfusion (I/R) insult via anti-oxidant properties. This study aims to investigate whether PUN provides cardioprotection against myocardial I/R (MI/R) injury and the underlying mechanisms. PUN (30[Formula: see text]mg/kg/d) or vehicle was intragastrically administered to Sprague-Dawley rats for one week before the operation. MI/R was induced by ligating the left anterior descending coronary artery for 30[Formula: see text]min and subsequent reperfusion for 3[Formula: see text]h...
2017: American Journal of Chinese Medicine
Na-Ra Han, Phil-Dong Moon, Na-Rae Kim, Hee-Yun Kim, Hyun-Ja Jeong, Hyung-Min Kim
Schisandra chinensis (SC) and its main constituent, schizandrin (SCH) exhibit anti-inflammatory and anti-allergic activities. Allergic and inflammatory reactions are aggravated via caspase-1 signaling pathway. However, the regulatory effects of SC and SCH on caspase-1 activation have not been clarified yet. In this study, we aimed to clarify the anti-allergic effects of SC and SCH using an ovalbumin (OVA)-sensitized mice and anti-CD3 and anti-CD28 antibodies-stimulated splenocytes. SC or SCH significantly inhibited the levels of immunoglobulin (Ig)E, IgG1, or interleukin (IL)-4 in serum of OVA-sensitized mice...
2017: American Journal of Chinese Medicine
An-Jan Tien, Chen-Yen Chien, Yueh-Hsi Chen, Lung-Chin Lin, Chiang-Ting Chien
Antrodia cinnamomea (A. cinnamomea), a popular medicinal mushroom in Taiwan, is widely used to prevent or treat liver diseases. Systematic studies on the anti-inflammatory effect of A. cinnamomea and its molecular mechanisms have not yet been fully investigated. HPLC fingerprint analysis identified seven ergostane-type triterpenoids from A. cinnamomea water extract (ACW), including high amounts of Antcin K (AC), Antcin C, Antcin H, Dehydrosulphurenic acid, Antcin B, Antcin A and Dehydroeburicoic acid. Here, we explored the effects and mechanisms of ACW and the highest content AC on N-nitrosodiethylamine (DEN) induced liver inflammation, fibrosis and carcinogenesis in rats...
2017: American Journal of Chinese Medicine
Jian-Jung Chen, Chung-Chun Huang, Heng-Yuan Chang, Pei-Ying Li, Yu-Chia Liang, Jeng-Shyan Deng, Shyh-Shyun Huang, Guan-Jhong Huang
Scutellaria baicalensis has been widely used as both a dietary ingredient and traditional herbal medicine in Taiwan to treat inflammation, cancer, and bacterial and viral infections of the respiratory tract and gastrointestinal tract. This paper aims to investigate the in vitro and in vivo anti-inflammatory effects of S. baicalensis. In HPLC analysis, the fingerprint chromatogram of the water extract of S. baicalensis (WSB) was established. The anti-inflammatory effects of WSB were inverstigated using lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW264...
2017: American Journal of Chinese Medicine
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