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American Journal of Chinese Medicine

Haiyi Wang, Guanhu Yang, Shaobai Wang, Xin Zheng, Wei Zhang, Yongming Li
Acupuncture has been a popular alternative medicine in the United States for several decades. Its therapeutic effects on pain have been validated by both basic and clinical researches, and it is currently emerging as a unique non-pharmaceutical choice for pain against opioid crisis. However, the full spectrum of acupuncture indications remains unexplored. In this study, we conducted a cross-sectional survey among 419 acupuncturists nation-wide to investigate the top 10 and top 99 acupuncture indications in private clinics in the United States...
October 9, 2018: American Journal of Chinese Medicine
Hyeneui Jeong, Jong-Won Kim, Myeon-Sik Yang, Chul Park, Jong Hoon Kim, Chae Woong Lim, Bumseok Kim
Korean red ginseng (KRG) is a traditional herbal medicine used to prevent several geriatric diseases due to its therapeutic effects on metabolic disorder, including type 2 diabetes and fatty liver disease. In this study, we investigated the effects of KRG on the progression of nonalcoholic steatohepatitis (NASH) in mice. NASH was induced by feeding a methionine- and choline-deficient high-fat or high-fat/high-sucrose diet for 6 or 13 weeks, respectively. Each diet group was also orally administered saline (group G0) or KRG extract (100, 200, or 400 mg/kg/day; groups G1, G2, and G4, respectively)...
October 9, 2018: American Journal of Chinese Medicine
Peile Wang, Jing Yang, Zhenfeng Zhu, Xiaojian Zhang
The stems and roots of Marsdenia tenacissima (Roxb.) Wight et Arn., a traditional Chinese medicine and Dai herbal medicine, have been widely used for the treatment of asthma, trachitis, tonsillitis, pharyngitis, cystitis, pneumonia and drug or food poisoning. Nowadays, the extract of Marsdenia tenacissima, under the trademark of "Xiao-ai-ping", is widely used in clinic for the treatment of different cancers in China. To date, approximately 196 chemical ingredients covering steroids, triterpenes and organic acids have been identified from different parts of this plant...
October 4, 2018: American Journal of Chinese Medicine
Yuan-Cheng Si, Wei-Na Miao, Jia-Yue He, Li Chen, Yi-Li Wang, Wei-Jun Ding
Recently, gut flora has been linked to the onset of obesity and has been shown to influence the host's metabolism. Acupuncture is a well-known agent used for the treatment of numerous diseases such as obesity. This study aimed to explore the impacts of electroacupuncture treatment on gut microbiota composition and function in obese mice. Pyrosequencing of 16S rRNA genes and Metagenomic analysis of the fecal microbiota were used for this purpose. The basic parameters of body weight, Lee's index, serum lipid and epididymal adipose weight were ameliorated significantly after introducing an electroacupuncture intervention...
October 4, 2018: American Journal of Chinese Medicine
Hung-En Chen, Ji-Fan Lin, Te-Fu Tsai, Yi-Chia Lin, Kuang-Yu Chou, Thomas I-Sheng Hwang
Allyl isothiocyanate (AITC), one of the most widely studied phytochemicals, inhibits the survival of human prostate cancer cells while minimally affecting normal prostate epithelial cells. Our study demonstrates the mechanism of AITC-induced cell death in prostate cancer cells. AITC induces autophagy in RV1 and PC3 cells, judging from the increased level of LC3-II protein in a dose- and time-dependent manner, but not in the normal prostate epithelial cell (PrEC). Inhibition of autophagy in AITC-treated cells decreased cell viability and enhanced apoptosis, suggesting that the autophagy played a protective role...
October 4, 2018: American Journal of Chinese Medicine
Dool-Ri Oh, Yujin Kim, Eun-Jin Choi, Ara Jo, Jawon Shin, Huwon Kang, Seul-Gi Lee, Jaeyong Kim, Young Ran Kim, Chul Yung Choi
The present study evaluates the anti-oxidative stress activity of Vaccinium bracteatum Thunb. fruit extract (VBFW) to identify the mechanisms responsible for its antidepressant-like effects. To evaluate the antidepressant and anti-oxidant effects of VBFW, malondialdehyde (MDA), serotonin transporter (SERT), and monoamine oxidase A (MAO-A) levels were measured in a mouse model of chronic restraint stress (CRS). The underlying mechanisms preventing oxidative stress and neuronal apoptosis were investigated using in vitro models of hydrogen peroxide (H2 O[Formula: see text]-induced neuronal damage...
October 4, 2018: American Journal of Chinese Medicine
Chih-Chia Huang, Mang-Hung Tsai, Ya-Chieh Wu, Kuang-Ti Chen, Han-Wen Chuang, Yun Chen, Guan-Woei Tseng, Pin-I Fu, I-Hua Wei
Puerarin is a traditional Chinese medicine with beneficial effects of reduced depression-like behaviors in mice with stress. Previous studies also show that puerarin can produce neuroprotective effect via activating the Akt or increased brain-derived neurotrophic factor (BDNF) expression. Interestingly, BDNF and Akt downstream target, mammalian target of rapamycin (mTOR) mediate the fast-acting antidepressant properties of ketamine. Until now, the involvement of the mTOR signaling pathway or BDNF on puerarin-induced antidepressant effect remains unknown...
October 4, 2018: American Journal of Chinese Medicine
Zhen Yang Cui, Eunbi Jo, Hyun Jin Jang, In-Hu Hwang, Kyung-Bok Lee, Hwa-Seung Yoo, Soo Jung Park, Mi-Kyung Jung, Yeon Wol Lee, Ik-Soon Jang
The cytokine C-X-C motif chemokine ligand 8 (CXCL8) is produced in the tumor microenvironment and has an important role in cancer pathogenesis. CXCL8 activates the nuclear factor (NF)-[Formula: see text]B signaling. However, the role of NF-[Formula: see text]B inactivation in apoptosis induced by negative regulation of CXCL8 remains unclear. Here, we assessed the effects of MRGX on the transcriptional activity of NF-[Formula: see text]B and the expression of tumor necrosis factor (TNF)-[Formula: see text]-stimulated target genes in liver cancer cells...
October 4, 2018: American Journal of Chinese Medicine
Ya-Jen Chiu, Chi-Mei Lee, Te-Hsien Lin, Hsuan-Yuan Lin, Shin-Ying Lee, Mina Mesri, Kuo-Hsuan Chang, Jung-Yaw Lin, Guey-Jen Lee-Chen, Chiung-Mei Chen
Amyloid [Formula: see text] (A[Formula: see text]) plays a major role in the pathogenesis of Alzheimer's disease (AD). The accumulation of misfolded A[Formula: see text] causes oxidative and inflammatory damage leading to apoptotic cell death. Chinese herbal medicine (CHM) has been widely used in clinical practice to treat neurodegenerative diseases associated with oxidative stress and neuroinflammation. This study examined the neuroprotection effects of CHM extract Glycyrrhiza inflata (G. inflata) and its active constituents, licochalcone A and liquiritigenin in AD...
October 4, 2018: American Journal of Chinese Medicine
Zhao-Hui Xu, Ying-Ying Gao, Hua-Ting Zhang, Ke-Feng Ruan, Yi Feng
Diabetic retinopathy (DR), one of the most common microvascular complications of diabetic mellitus, is currently the main cause of adult-acquired blindness. The pathogenesis of DR is complex and the current clinical application of various treatment methods cannot completely prevent the development of this disease. Many reports have been published regarding the treatment of DR with Traditional Chinese Medicine (TCM), which has received increasing attention from medical practitioners worldwide. Studies published between 1994 and April 2017 were collected from the CNKI, VIP, Medline and Web of Science databases, as well as from Chinese traditional books and Chinese Pharmacopoeia, subsequently obtaining more than 550 studies...
October 4, 2018: American Journal of Chinese Medicine
Zengjie Zhang, Chenggui Wang, Jialiang Lin, Haiming Jin, Ke Wang, Yingzhao Yan, Jianle Wang, Congcong Wu, Majid Nisar, Naifeng Tian, Xiangyang Wang, Xiaolei Zhang
Intervertebral disc degeneration (IDD) is a major cause of lower back pain, but few efficacious medicines have been developed for IDD. Increased nucleus pulposus cells apoptosis is a dominant pathogenesis of IDD and is considered a therapeutic target. Previously, our group proved that autophagy may protect nucleus pulposus cells against apoptosis. As one of the major bioflavonoids of citrus, naringin activates autophagy. Therefore, we hypothesize that naringin may have therapeutic potential for IDD by activating autophagy in nucleus pulposus cells...
October 4, 2018: American Journal of Chinese Medicine
Ruoming Fang, Renyi Wu, Qian Zuo, Ran Yin, Chengyue Zhang, Chao Wang, Yue Guo, Anne Yuqing Yang, Wenji Li, Lizhu Lin, Ah-Ng Kong
Qu-Yu-Jie-Du decoction (QYJD) is a commercially available traditional Chinese medicine (TCM). It is an aqueous extract of a Chinese herbal formula primarily consisting of eight TCM herbs: Taraxacum campylodes G.E. Haglund, Coix lacryma-jobi L., Smilax glabra Roxb., Sanguisorba officinalis L, Styphnolobium japonicum (L.) Schott, Prunus persica (L.) Batsch, Sophora flavescens Aiton, and Eupolyphaga sinensis Walker. Matrine and oxymatrine are two of the major phytochemical constituents of QYJD. Inflammation and oxidative stress are strongly associated with colon carcinogenesis...
October 4, 2018: American Journal of Chinese Medicine
Wei Xiong, Fang-Fang He, Ren-Yu You, Jing Xiong, Yu-Mei Wang, Chun Zhang, Xian-Fang Meng, Hua Su
Chronic kidney disease (CKD) is an increasing major public health problem worldwide. The number of CKD patients on hemodialysis is growing rapidly as well. Acupuncture technique is one of the traditional Chinese medicine methods and has been used in a variety of diseases. Nowadays, the clinical application of acupuncture technique for CKD patients has become the focus for its effectiveness and security. In this paper, we will review the therapeutic effects and mechanisms of different acupuncture techniques for CKD patients...
2018: American Journal of Chinese Medicine
Ui-Jin Bae, Eun-Ock Park, John Park, Su-Jin Jung, Hyeonmi Ham, Kee-Won Yu, Young-Jun Park, Soo-Wan Chae, Byung-Hyun Park
Nonalcoholic steatohepatitis (NASH) arises from nonalcoholic fatty liver disease (NAFLD) as a consequence of oxidative stress. Gynostemma pentaphyllum extract (GPE) is proven to be beneficial for patients suffering from NAFLD. However, the precise mechanism by which GPE confers these benefits remains largely unknown. The purpose of this study was to investigate the underlying mechanism and to determine whether supplementation with the newly discovered GPE gypenoside UL4 mitigates NASH progression. Male c57BL/6 mice were fed a normal chow diet, a methionine choline-deficient (MCD) diet, or an MCD diet supplemented with various doses of UL4-rich GPE for eight weeks...
2018: American Journal of Chinese Medicine
Bosung Kim, Eun-Yeong Kim, Eun-Ji Lee, Jung Ho Han, Chung-Hwan Kwak, Yeon-Seop Jung, Syng-Ook Lee, Tae-Wook Chung, Ki-Tae Ha
Among the herbal ingredients of HangAmDan-B, a medicinal formula that redirects macrophages to become tumoricidal effectors, we found that Panax notoginseng (Burk.) F. H. Chen is the active component responsible for its macrophage-mediated antitumor activity. The water extracted roots of P. notoginseng (PN) did not affect the viability of RAW264.7 murine macrophage-like cells and murine Lewis lung carcinoma (LLC) cells up to a concentration of 100[Formula: see text][Formula: see text]g/mL. However, the transfer of culture media from PN-treated RAW264...
2018: American Journal of Chinese Medicine
Dewei Wu, Qiao Zhang, Yangyang Yu, Yuxin Zhang, Minyu Zhang, Qing Liu, Erli Zhang, Shiyou Li, Guangyuan Song
Endothelin-1 (ET-1) and its receptor endothelin A receptor (ET[Formula: see text] have been shown to be upregulated in a high glucose environment, which increase the incidence of diabetes-related heart failure. Our previous study demonstrated that oleanolic acid (OA), a natural compound found in Chinese herbs had ET-1 antagonistic effects. We aimed to verify whether OA could ameliorate diabetes mellitus (DM)-induced injury in cardiomyocytes by reducing the antagonistic effects of the ET-1 pathway. For the induction of high glucose-related injury in cardiomyocytes, neonatal rat ventricular cardiomyocytes (NRVMs) were subjected to culture medium containing 25[Formula: see text]mM of glucose...
2018: American Journal of Chinese Medicine
Jung-Won Shin, Ki-Jung Kweon, Dong-Kyu Kim, Pyungsoo Kim, Tae-Dong Jeon, Sungho Maeng, Nak-Won Sohn
Chronic cerebral hypoperfusion is considered as a pivotal factor of cognitive impairment that occurs in cerebrovascular diseases. This study investigated the ameliorating effect of scutellarin (SCT) on spatial cognitive impairment and [Formula: see text]-amyloid (A[Formula: see text]) formation in rats with chronic cerebral hypoperfusion induced by permanent bilateral common carotid artery occlusion (pBCAO). SCT is a flavonoid in medicinal herb of Erigeron breviscapus (vant.) Hand. Mazz. known to have neuroprotective, antioxidative and anti-inflammatory effects...
2018: American Journal of Chinese Medicine
Yucong Peng, Pingyou He, Linfeng Fan, Hangzhe Xu, Jianru Li, Ting Chen, Wu Ruan, Zhangqi Dou, Gao Chen
Subarachnoid hemorrhage (SAH) is a severe cerebrovascular disease with few effective pharmacotherapies available. Salvia miltiorrhiza, a traditional Chinese medicinal herb, has been widely used to treat cardiovascular diseases for centuries. Recent studies have demonstrated that magnesium lithospermate B (MLB), a bioactive ingredient extracted from Salvia miltiorrhiza, exerts neuroprotective effects in several central nervous system insults. However, little is known about the role of MLB in SAH-induced brain injury and the exact molecular mechanism...
2018: American Journal of Chinese Medicine
Juyeon Ham, Seungyeon Lee, Hyunkyung Lee, Dawoon Jeong, Sungbin Park, Sun Jung Kim
Ginsenoside Rg3 is a key metabolite of ginseng and is known to inhibit cancer cell growth. However, the epigenetics of CpG methylation and its regulatory mechanism have yet to be determined. Genome-wide methylation analysis of MCF-7 breast cancer cells treated with Rg3 was performed to identify epigenetically regulated genes and pathways. The effect of Rg3 on apoptosis and cell proliferation was examined by a colony formation assay and a dye-based cell proliferation assay. The association between methylation and gene expression was monitored by RT-PCR and Western blot analysis...
2018: American Journal of Chinese Medicine
Hyun Jong Kim, Yu Ran Nam, Eun-Jung Kim, Joo Hyun Nam, Woo Kyung Kim
Intracellular calcium signaling cascades are integral to early and late allergic responses involving mast cell degranulation and type 2 helper T cell activation, respectively. Both the responses are accompanied by the movement of calcium through the calcium release-activated calcium (CRAC) channel, encoded by the ORAI1 gene. Spirodela polyrhiza (L.) Schleid (SP) has anti-inflammatory and anti-allergic effects, but its effect on calcium signaling has not been reported. This study investigated whether a 30% ethanolic SP extract (SPEtOH ) and its constituents can reduce CRAC currents ([Formula: see text]), and thus inhibit mast cell degranulation and T cell activation...
2018: American Journal of Chinese Medicine
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