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American Journal of Chinese Medicine

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https://www.readbyqxmd.com/read/29132216/curcumin-decreases-hyperphosphorylation-of-tau-by-down-regulating-caveolin-1-gsk-3%C3%AE-in-n2a-app695swe-cells-and-app-ps1-double-transgenic-alzheimer-s-disease-mice
#1
Jieyun Sun, Xiong Zhang, Chen Wang, Zhipeng Teng, Yu Li
Caveolin-1, the marker protein of membranal caveolae, is not only involved in cholesterol regulation, but also participates in the cleavage of amyloid [Formula: see text]-protein precursor (APP) and the generation of [Formula: see text]-amyloid peptide. It has been reported to be tightly related with Tau. In our previous studies, curcumin has been confirmed to play a neuroprotective role in Alzheimer's disease (AD), but its effects on Caveolin-1, Tau and their correlation, and the mechanism is still unknown...
November 13, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29121805/prostate-cancer-xenograft-inhibitory-activity-and-pharmacokinetics-of-decursinol-a-metabolite-of-angelica-gigas-pyranocoumarins-in-mouse-models
#2
Wei Wu, Su-Ni Tang, Yong Zhang, Manohar Puppala, Timothy K Cooper, Chengguo Xing, Cheng Jiang, Junxuan Lü
We have previously shown that the ethanol extract of dried Angelica gigas Nakai (AGN) root exerts anticancer activity against androgen receptor (AR)-negative human DU145 and PC-3 prostate cancer xenografts and primary carcinogenesis in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. The major pyranocoumarin isomers decursin (D) and decursinol angelate (DA), when provided at equi-molar intake to that provided by AGN extract, accounted for the inhibitory efficacy against precancerous epithelial lesions in TRAMP mice...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29121804/melaleuca-alternifolia-induces-heme-oxygenase-1-expression-in-murine-raw264-7-cells-through-activation-of-the-nrf2-are-pathway
#3
Shih-Yu Lee, Po-Yu Chen, Jung-Chun Lin, Nicholas S Kirkby, Ching-Huei Ou, Tsu-Chung Chang
Melaleuca alternifolia concentrate (MAC) is the refined essential oil of the Australian native plant Melaleuca alternifolia. MAC has been reported to suppress the production of pro-inflammatory cytokines in both murine RAW264.7 macrophages and human monocytes stimulated with lipopolysaccharide (LPS). However, the mechanisms involved in this effect remain unclear. This study aims to delineate the molecular mechanisms that drive the anti-inflammatory activity of MAC and its active component, terpinen-4-ol, in macrophages...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29121803/carnosol-induced-ros-inhibits-cell-viability-of-human-osteosarcoma-by-apoptosis-and-autophagy
#4
Yu-Cheng Lo, Yung-Chi Lin, Yi-Fu Huang, Chen-Pu Hsieh, Chia-Chieh Wu, Ing-Lin Chang, Chiu-Liang Chen, Chun-Hsiang Cheng, Hsin-Yao Chen
Carnosol is an anti-oxidant and anti-inflammatory compound from rosemary. In this report, we investigated antitumor activity of carnosol against human osteosarcoma cells. We found the viability of human osteosarcoma MG-63 cells was significantly decreased in the presence of carnosol (cell viabilities: 17.2% for 20[Formula: see text][Formula: see text]g/ml of CS vs. 100% for control, [Formula: see text]). Carnosol induced apoptosis and cell cycle arrest in a dose-dependent manner in MG-63 cells. Furthermore, carnosol exposure increased the levels of reactive oxygen species (ROS)...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29121802/hispolon-suppresses-lps-or-lta-induced-inos-no-production-and-apoptosis-in-bv-2-microglial-cells
#5
Ming-Shun Wu, Chih-Chiang Chien, Kur-Ta Cheng, Gottumukkala V Subbaraju, Yen-Chou Chen
Hispolon (HIS) is an active polyphenol compound derived from Phellinus linteus (Berkeley & Curtis), and our previous study showed that HIS effectively inhibited inflammatory responses in macrophages (Yang et al., 2014); however, its effect on neuronal inflammation is still undefined. In this study, HIS concentration- and time-dependently inhibited lipopolysaccharide (LPS)- and lipoteichoic acid (LTA)-induced inducible nitric oxide (NO) synthase (iNOS)/NO production with increased heme oxygenase (HO)-1 proteins in BV-2 microglial cells...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29121801/usefulness-of-chinese-herbal-medicines-as-host-directed-therapeutics-against-mycobacterial-infections-a-review
#6
Haruaki Tomioka
The high incidence of tuberculosis (TB) in developing countries, the resurgence of TB in industrialized countries, and the world-wide increase in the prevalence of Mycobacterium avium complex infections have prompted the quest for new antimycobacterial drugs. However, the development of such chemotherapeutics is currently making very slow progress. It therefore appears that devising improved administration protocols for clinical treatment against intractable mycobacteriosis using existing chemotherapeutics is more practical than awaiting the development of novel antimycobacterial drugs...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29121800/protective-effects-of-ginsenosides-on-17-formula-see-text-ethynyelstradiol-induced-intrahepatic-cholestasis-via-anti-oxidative-and-anti-inflammatory-mechanisms-in-rats
#7
Yan-Jiao Xu, Zao-Qin Yu, Cheng-Liang Zhang, Xi-Ping Li, Cheng-Yang Feng, Kai Lei, Wen-Xi He, Dong Liu
The present study was designed to assess the effects and potential mechanisms of ginsenosides on 17[Formula: see text]-ethynyelstradiol (EE)-induced intrahepatic cholestasis (IC). Ginsenoside at doses of 30, 100, 300[Formula: see text]mg/kg body weight was intragastrically (i.g.) given to rats for 5 days to examine the effect on EE-induced IC. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bile acid (TBA) were measured. Hepatic malondialdehyde (MDA) content and superoxide dismutase (SOD) activity were determined...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29121799/pueraria-lobate-inhibits-rankl-mediated-osteoclastogenesis-via-downregulation-of-creb-pgc1%C3%AE-c-fos-nfatc1-signaling
#8
Keun Ha Park, Dong Ryun Gu, Su Hyun Jin, Chi-Su Yoon, Wonmin Ko, Youn Chul Kim, Seoung Hoon Lee
Puerariae radix, the dried root of Pueraria lobate Ohwi, is known to prevent bone loss in ovariectomized mice; however, the precise molecular mechanisms are not understood. In this study, we investigated the effects and underlying mechanisms of action of Puerariae radix extract (PRE) on receptor activator of NF-[Formula: see text]B ligand (RANKL)-induced osteoclastogenesis. PRE dose-dependently inhibited osteoclast differentiation and formation, decreased the bone-resorbing activity of osteoclasts, and downregulated the expression of osteoclast differentiation marker genes...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29121798/angelica-sinensis-exerts-angiogenic-and-anti-apoptotic-effects-against-cerebral-ischemia-reperfusion-injury-by-activating-p38mapk-hif-1-formula-see-text-vegf-a-signaling-in-rats
#9
Chin-Yi Cheng, Tin-Yun Ho, Chien-Yun Hsiang, Nou-Ying Tang, Ching-Liang Hsieh, Shung-Te Kao, Yu-Chen Lee
This study evaluated the effects of Angelica sinensis extract [Dang Gui (DG)] administered before 60[Formula: see text]min of middle cerebral artery occlusion followed by 3[Formula: see text]d of reperfusion and investigated the involvement of mitogen-activated protein kinase (MAPK)/hypoxia-inducible factor (HIF)-1[Formula: see text] signaling in the cortical ischemic penumbra. DG was intraperitoneally administered at a dose of 0.25[Formula: see text]g/kg (DG-0.25g), 0.5[Formula: see text]g/kg (DG-0.5g), or 1[Formula: see text]g/kg (DG-1g) 30[Formula: see text]min before the onset of cerebral ischemia...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29121797/effectiveness-of-acupuncture-and-electroacupuncture-for-chronic-neck-pain-a-systematic-review-and-meta-analysis
#10
See Yoon Seo, Ki-Beom Lee, Joon-Shik Shin, Jinho Lee, Me-Riong Kim, In-Hyuk Ha, Youme Ko, Yoon Jae Lee
The aim of this systematic review was to assess evidence from randomized controlled trials (RCTs) on the effectiveness and safety of acupuncture and electroacupuncture in patients with chronic neck pain. We searched nine databases including Chinese, Japanese and Korean databases through 30 July 2016. The participants were adults with chronic neck pain and were treated with acupuncture or electroacupuncture. Eligible trials were those with intervention groups receiving acupuncture and electroacupuncture with or without active control, and control groups receiving other conventional treatments such as physical therapy or medication...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29121796/absorption-properties-of-luteolin-and-apigenin-in-genkwa-flos-using-in-situ-single-pass-intestinal-perfusion-system-in-the-rat
#11
Xin He, Zi-Jing Song, Cui-Ping Jiang, Chun-Feng Zhang
The flower bud of Daphne genkwa (Genkwa Flos) is a commonly used herbal medicine in Asian countries. Luteolin and apigenin are two recognized active flavonoids in Genkwa Flos. The aim of this study was to investigate the intestinal absorption mechanisms of Genkwa Flos flavonoids using in situ single-pass intestinal perfusion rat model. Using HPLC, we determined its major effective flavonoids luteolin, apigenin, as well as, hydroxygenkwanin and genkwanin in biological samples. The intestinal absorption mechanisms of the total flavonoids in Genkwa Flos (TFG) were investigated using in situ single-pass intestinal perfusion rat model...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29121795/berberine-ameliorates-diabetic-neuropathy-trpv1-modulation-by-pkc-pathway
#12
Yan Zan, Cui-Xing Kuai, Zhi-Xia Qiu, Fang Huang
In recent years, berberine has increasingly become a topic of research as a treatment for diabetes due to its repair function, which recovers damaged pancreatic β cells. However, it is the complications of diabetes that seriously affect patients' life quality and longevity, among which diabetic neuropathy and the consequent acute pain are the most common. In this study, we established STZ-induced diabetic models to observe whether berberine, a main constitute of Coptis chinensis Franch which has shown good hypoglycemic effects, could relieve diabetes-induced pain and explored its possible mechanism in rats and mice...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29025293/berberine-induces-apoptotic-cell-death-via-activation-of-caspase-3-and-8-in-hl-60-human-leukemia-cells-nuclear-localization-and-structure-activity-relationships
#13
Shinya Okubo, Takuhiro Uto, Aya Goto, Hiroyuki Tanaka, Tsuyoshi Nishioku, Katsushi Yamada, Yukihiro Shoyama
Berberine (BBR), an isoquinoline alkaloid, is a well-known bioactive compound contained in medicinal plants used in traditional and folk medicines. In this study, we investigated the subcellular localization and the apoptotic mechanisms of BBR were elucidated. First, we confirmed the incorporation of BBR into the cell visually. BBR showed antiproliferative activity and promptly localized to the nucleus from 5[Formula: see text]min to 15[Formula: see text]min after BBR treatment in HL-60 human promyelocytic leukemia cells...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28950713/literature-review-herbal-medicine-treatment-after-large-scale-disasters
#14
Shin Takayama, Soichiro Kaneko, Takehiro Numata, Tetsuharu Kamiya, Ryutaro Arita, Natsumi Saito, Akiko Kikuchi, Minoru Ohsawa, Yoshitaka Kohayagawa, Tadashi Ishii
Large-scale natural disasters, such as earthquakes, tsunamis, volcanic eruptions, and typhoons, occur worldwide. After the Great East Japan earthquake and tsunami, our medical support operation's experiences suggested that traditional medicine might be useful for treating the various symptoms of the survivors. However, little information is available regarding herbal medicine treatment in such situations. Considering that further disasters will occur, we performed a literature review and summarized the traditional medicine approaches for treatment after large-scale disasters...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28950712/maydis-stigma-elicits-analgesia-and-blocks-edema-in-mice-and-inhibits-inflammation-in-macrophages
#15
Yun Hee Jeong, You-Chang Oh, Won-Kyung Cho, Hye Jin Yang, Jin Yeul Ma
Maydis Stigma (MS) is an herb traditionally used in many parts of the world. Previous studies have reported that MS plays a role in several biological activities, including antidiabetic and anticancer activities. However, the effects of a MS ethanolic extract (MSE) on the anti-inflammatory cellular mechanism remain unclear. Here, we investigated the anti-inflammatory properties of MSE and its molecular mechanism both in vitro and in vivo. The effects of MSE on the production of inflammatory mediators, cytokines, and related proteins and the identification of target genes were determined using LPS-stimulated macrophages...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28946772/combination-of-cinobufacini-and-doxorubicin-increases-apoptosis-of-hepatocellular-carcinoma-cells-through-the-fas-and-mitochondria-mediated-pathways
#16
Jufeng Xia, Yoshinori Inagaki, Jianjun Gao, Fanghua Qi, Peipei Song, Guohua Han, Tatsuo Sawakami, Bo Gao, Chuan Luo, Norihiro Kokudo, Kiyoshi Hasegawa, Yoshihiro Sakamoto, Wei Tang
Cinobufacini, a traditional Chinese medicine, has been used widely for cancer treatment, such as hepatocellular carcinoma (HCC), sarcoma, and leukemia. Previous studies done by our lab indicated that cinobufacini could suppress HCC cells through mitochondria-mediated and Fas-mediated apoptotic pathways. Here, we use a combination of cinobufacini and doxorubicin to inhibit the growth of HCC cells. The combination group induced more significant apoptosis by affecting proteins and RNA of apoptosis-related elements, such as Bcl-2, Bax, Bid, and cytochrome c...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28946771/rubus-idaeus-inhibits-migration-and-invasion-of-human-nasopharyngeal-carcinoma-cells-by-suppression-of-mmp-2-through-modulation-of-the-erk1-2-pathway
#17
Chung-Han Hsin, Cheng-Chen Huang, Pei-Ni Chen, Yih-Shou Hsieh, Shun-Fa Yang, Yu-Ting Ho, Chiao-Wen Lin
Nasopharyngeal carcinoma (NPC) is characterized by a high incidence of metastasis in the neck lymph nodes, resulting in a poor prognosis and posing challenges for treatment. In this study, we investigated the in vitro antimetastatic properties of Rubus idaeus extract (RIE) on human nasopharyngeal carcinoma cells. HONE-1, NPC-39 and NPC-BM cells were subjected to RIE treatment, and effects on the migration and invasion of tumor cells were analyzed. The results showed that RIE suppressed the migration and invasion of NPC cells...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28946770/estrogenic-potentials-of-traditional-chinese-medicine
#18
Ryoiti Kiyama
Estrogen, a steroid hormone, is associated with several human activities, including environmental, industrial, agricultural, pharmaceutical and medical fields. In this review paper, estrogenic activity associated with traditional Chinese medicines (TCMs) is discussed first by focusing on the assays needed to detect estrogenic activity (animal test, cell assay, ligand-binding assay, protein assay, reporter-gene assay, transcription assay and yeast two-hybrid assay), and then, their sources, the nature of activities (estrogenic or anti-estrogenic, or other types), and pathways/functions, along with the assay used to detect the activity, which is followed by a summary of effective chemicals found in or associated with TCM...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28946769/magnolol-reduces-renal-ischemia-and-reperfusion-injury-via-inhibition-of-apoptosis
#19
Chia-Yu Tang, Chang-Chi Lai, Po-Hsun Huang, An-Han Yang, Shu-Chiung Chiang, Po-Chao Huang, Kuo-Wei Tseng, Cheng-Hsiung Huang
Magnolol, a constituent of the bark of Magnolia officinalis, has been reported to decrease myocardial stunning and infarct size. In this study, we investigated whether magnolol can reduce renal ischemia and reperfusion (I/R) injury. Renal I/R, induced by a 60-min occlusion of bilateral renal arteries and a 24-h reperfusion, significantly increased blood urea nitrogen (BUN) and creatinine levels, and caused histological damage to the kidneys of rats. Apoptosis, as evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining and caspase-3 activation, was significantly increased in the kidneys...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28946768/roles-of-autophagy-in-ischemic-heart-diseases-and-the-modulatory-effects-of-chinese-herbal-medicine
#20
Dawei Wang, Weiqing Yu, Yuntao Liu, Guofu Zhong, Zhen Zhao, Xia Yan, Qing Liu
Autophagy is an evolutionarily conserved degradation process which eliminates dysfunctional proteins and cytoplasmic components to maintain homeostasis for cell survival. Increasing evidence has demonstrated the modulatory role of autophagy in ischemic heart diseases (IHDs). Traditionally, this process has been recognized as having protective functions, such as inhibiting atherosclerosis progression and reducing cell death during the ischemic phase. However, recent studies have suggested its dual roles in myocardial ischemia/reperfusion (MIR) injury...
2017: American Journal of Chinese Medicine
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