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American Journal of Chinese Medicine

Ui-Jin Bae, Eun-Ock Park, John Park, Su-Jin Jung, Hyeonmi Ham, Kee-Won Yu, Young-Jun Park, Soo-Wan Chae, Byung-Hyun Park
Nonalcoholic steatohepatitis (NASH) arises from nonalcoholic fatty liver disease (NAFLD) as a consequence of oxidative stress. Gynostemma pentaphyllum extract (GPE) is proven to be beneficial for patients suffering from NAFLD. However, the precise mechanism by which GPE confers these benefits remains largely unknown. The purpose of this study was to investigate the underlying mechanism and to determine whether supplementation with the newly discovered GPE gypenoside UL4 mitigates NASH progression. Male c57BL/6 mice were fed a normal chow diet, a methionine choline-deficient (MCD) diet, or an MCD diet supplemented with various doses of UL4-rich GPE for eight weeks...
September 5, 2018: American Journal of Chinese Medicine
Bosung Kim, Eun-Yeong Kim, Eun-Ji Lee, Jung Ho Han, Chung-Hwan Kwak, Yeon-Seop Jung, Syng-Ook Lee, Tae-Wook Chung, Ki-Tae Ha
Among the herbal ingredients of HangAmDan-B, a medicinal formula that redirects macrophages to become tumoricidal effectors, we found that Panax notoginseng (Burk.) F. H. Chen is the active component responsible for its macrophage-mediated antitumor activity. The water extracted roots of P. notoginseng (PN) did not affect the viability of RAW264.7 murine macrophage-like cells and murine Lewis lung carcinoma (LLC) cells up to a concentration of 100[Formula: see text][Formula: see text]g/mL. However, the transfer of culture media from PN-treated RAW264...
August 31, 2018: American Journal of Chinese Medicine
Dewei Wu, Qiao Zhang, Yangyang Yu, Yuxin Zhang, Minyu Zhang, Qing Liu, Erli Zhang, Shiyou Li, Guangyuan Song
Endothelin-1 (ET-1) and its receptor endothelin A receptor (ET[Formula: see text] have been shown to be upregulated in a high glucose environment, which increase the incidence of diabetes-related heart failure. Our previous study demonstrated that oleanolic acid (OA), a natural compound found in Chinese herbs had ET-1 antagonistic effects. We aimed to verify whether OA could ameliorate diabetes mellitus (DM)-induced injury in cardiomyocytes by reducing the antagonistic effects of the ET-1 pathway. For the induction of high glucose-related injury in cardiomyocytes, neonatal rat ventricular cardiomyocytes (NRVMs) were subjected to culture medium containing 25[Formula: see text]mM of glucose...
August 27, 2018: American Journal of Chinese Medicine
Jung-Won Shin, Ki-Jung Kweon, Dong-Kyu Kim, Pyungsoo Kim, Tae-Dong Jeon, Sungho Maeng, Nak-Won Sohn
Chronic cerebral hypoperfusion is considered as a pivotal factor of cognitive impairment that occurs in cerebrovascular diseases. This study investigated the ameliorating effect of scutellarin (SCT) on spatial cognitive impairment and [Formula: see text]-amyloid (A[Formula: see text]) formation in rats with chronic cerebral hypoperfusion induced by permanent bilateral common carotid artery occlusion (pBCAO). SCT is a flavonoid in medicinal herb of Erigeron breviscapus (vant.) Hand. Mazz. known to have neuroprotective, antioxidative and anti-inflammatory effects...
August 27, 2018: American Journal of Chinese Medicine
Yucong Peng, Pingyou He, Linfeng Fan, Hangzhe Xu, Jianru Li, Ting Chen, Wu Ruan, Zhangqi Dou, Gao Chen
Subarachnoid hemorrhage (SAH) is a severe cerebrovascular disease with few effective pharmacotherapies available. Salvia miltiorrhiza, a traditional Chinese medicinal herb, has been widely used to treat cardiovascular diseases for centuries. Recent studies have demonstrated that magnesium lithospermate B (MLB), a bioactive ingredient extracted from Salvia miltiorrhiza, exerts neuroprotective effects in several central nervous system insults. However, little is known about the role of MLB in SAH-induced brain injury and the exact molecular mechanism...
August 27, 2018: American Journal of Chinese Medicine
Juyeon Ham, Seungyeon Lee, Hyunkyung Lee, Dawoon Jeong, Sungbin Park, Sun Jung Kim
Ginsenoside Rg3 is a key metabolite of ginseng and is known to inhibit cancer cell growth. However, the epigenetics of CpG methylation and its regulatory mechanism have yet to be determined. Genome-wide methylation analysis of MCF-7 breast cancer cells treated with Rg3 was performed to identify epigenetically regulated genes and pathways. The effect of Rg3 on apoptosis and cell proliferation was examined by a colony formation assay and a dye-based cell proliferation assay. The association between methylation and gene expression was monitored by RT-PCR and Western blot analysis...
August 27, 2018: American Journal of Chinese Medicine
Hyun Jong Kim, Yu Ran Nam, Eun-Jung Kim, Joo Hyun Nam, Woo Kyung Kim
Intracellular calcium signaling cascades are integral to early and late allergic responses involving mast cell degranulation and type 2 helper T cell activation, respectively. Both the responses are accompanied by the movement of calcium through the calcium release-activated calcium (CRAC) channel, encoded by the ORAI1 gene. Spirodela polyrhiza (L.) Schleid (SP) has anti-inflammatory and anti-allergic effects, but its effect on calcium signaling has not been reported. This study investigated whether a 30% ethanolic SP extract (SPEtOH ) and its constituents can reduce CRAC currents ([Formula: see text]), and thus inhibit mast cell degranulation and T cell activation...
August 27, 2018: American Journal of Chinese Medicine
Kai Wang, Sheng-Lan Tan, Qiong Lu, Ran Xu, Jian Cao, Shui-Qing Wu, Yin-Huai Wang, Xiao-Kun Zhao, Zhao-Hui Zhong
Bladder cancer has a high recurrence rate and requires adjuvant intravesical management after surgery. The use of traditional agents for bladder cancer therapy is constrained by their toxicity and limited efficacy. This emphasizes the need for the development of safer, more effective compounds such as instillation agents. Curcumin is the major component of turmeric, the powdered root of Curcuma longa, which is known for its anti-inflammatory, anti-oxidant and anticancer properties. First, a microarray profiling and qPCR analysis were conducted in the T24 and SV-HUC-1 cell lines...
August 27, 2018: American Journal of Chinese Medicine
Xiaxia Wu, Yanling Guo, Xiangjing Min, Lixia Pei, Xiuping Chen
Both the incidence and prevalence of ulcerative colitis (UC) are increasing throughout the world. Neferine, a natural alkaloid, demonstrated a variety of biological activities. In this study, the anti-inflammatory effect of neferine was investigated. Raw264.7 cells were stimulated with lipopolysaccharide (LPS) or LPS plus Z-VAD-fmk (Z-VAD). The inhibitory effect of neferine on secretion of nitrite, cytokines tumor necrosis factor alpha (TNF-[Formula: see text]) and interleukin 6 (IL-6), expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) was determined...
August 27, 2018: American Journal of Chinese Medicine
Sang Yun Han, Young-Su Yi, Seong-Gu Jeong, Yo Han Hong, Kang Jun Choi, Mohammad Amjad Hossain, Hyunsik Hwang, Ho Sik Rho, Jongsung Lee, Jong-Hoon Kim, Jae Youl Cho
Lilium bulbs have long been used as Chinese traditional medicines to alleviate the symptoms of various human inflammatory diseases. However, mechanisms of Lilium bulb-mediated anti-inflammatory activity and the bioactive components in Lilium bulbs remain unknown. In the present study, the anti-inflammatory activity of Lilium bulbs and the underlying mechanism of action were investigated in macrophages using Lilium bulb ethanol extracts (Lb-EE). In a dose-dependent manner, Lb-EE inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264...
August 27, 2018: American Journal of Chinese Medicine
I-Chuan Yen, Li-Shian Shi, Min-Chieh Chung, Blerina Ahmetaj-Shala, Tsu-Chung Chang, Shih-Yu Lee
Antrodia cinnamomea, a medicinal mushroom, has previously demonstrated anti-inflammatory activity, although the specific compound responsible for the effect remains unclear. The present study was designed to investigate the anti-inflammatory property of antrolone, a novel benzoid derived from A. cinnamomea mycelium, and to clarify the underlying mechanisms of action. To this end, murine macrophage RAW264.7 cells were treated with antrolone (0.1-30[Formula: see text][Formula: see text]M) 30[Formula: see text]min prior to stimulation with lipopolysaccharides (LPS, 0...
August 27, 2018: American Journal of Chinese Medicine
Yuan Xu, Shouhai Hong, Xue Zhao, Shenjun Wang, Zhifang Xu, Shasha Ding, Kuo Zhang, Yiping Zhang, Lianjie Xu, Nannan Yu, Tianyi Zhao, Yawen Yan, Fuming Yang, Yangyang Liu, Kun Yu, Baohu Liu, Yi Guo, Guangchang Pang
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory and debilitating disease that involves the systemic imbalance of the immune network. Previous studies have shown that acupuncture can help treat RA. However, its specific mechanisms are not fully understood. Thus, the present study was designed to clarify the mechanisms of acupuncture acted on RA via immune network modulation using complete Freund's adjuvant (CFA)-induced arthritic rats. Results revealed that manual acupuncture (MA) could alleviate the inflammation and pain of infected joints...
2018: American Journal of Chinese Medicine
Wei-Liang Zhang, Yong-Liang Chi, Lian-Zhu Wang, Hui Liu, Lu-Xi Zhao, Fan Su
Postoperative cognitive dysfunction (POCD) is one of the major complications in patients who have undergone surgeries. Reduction of surgery-induced inflammation and perioperative stress responses may prevent the development of POCD. As recent experimental data have suggested, Shenmai and Shenfu injections, two ginseng containing formulations, may improve cognition. We designed this study using aged rats as an experimental model to determine the effect of combined perioperative Shenmai injection and Shenfu injection in preventing the development of POCD and exploring the underlying mechanism of this intervention...
2018: American Journal of Chinese Medicine
Xia-Wei Zhang, Wei Liu, Hong-Li Jiang, Bing Mao
Chinese herbal medicine (CHM) has been widely used in the treatment of advanced non-small-cell lung cancer (NSCLC), but their efficacy and safety remain controversial. We sought to comprehensively aggregate and evaluate the available evidence on the efficacy and safety of the combination treatment with CHM and epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in NSCLC patients. Our exhausted and systematical searching strategy yielded 64 related randomized controlled trials involving 4384 patients...
2018: American Journal of Chinese Medicine
Simei Sun, Tianyi Li, Li Jin, Zhe Hao Piao, Bin Liu, Yuhee Ryu, Sin Young Choi, Gwi Ran Kim, Ji Eun Jeong, An Jin Wi, Song Ju Lee, Hae Jin Kee, Myung Ho Jeong
An extract of Dendropanax morbifera branch exerts antioxidant, anti-inflammatory, antithrombotic, and anticancer activities. The purpose of this study was to investigate the effect of the extract in isoproterenol-induced cardiac hypertrophy. Phalloidin staining showed that treatment with the extract dramatically prevents isoproterenol-induced H9c2 cell enlargement and the expression of cardiac hypertrophic marker genes, including atrial natriuretic peptide (ANP) and B-type brain natriuretic peptide (BNP). Further, pretreatment with the extract decreased isoproterenol-induced GATA4 and Sp1 expression in H9c2 cells...
2018: American Journal of Chinese Medicine
Sumei Wang, Shunqin Long, Wanyin Wu
Although lots of great achievements have been gained in the battle against cancer during the past decades, cancer is still the leading cause of death in the world including in developing countries such as China. Traditional Chinese medicine (TCM) is popular in Chinese and East Asian societies as well as some other Western countries and plays an active role in the modern healthcare system including patients with cancer, which may act as a potential effective strategy in treating human cancers. In this review, we aimed to introduce the mechanisms of TCM compound, as an option of individualized therapy, in treating cancer patients from the perspective of both Chinese and Western medicine...
2018: American Journal of Chinese Medicine
Yu-An Hsu, Yi-Hsin Kuo, Chih-Sheng Chen, Ying-Chi Chen, Chi-Chun Huang, Ching-Yao Chang, Chao-Jen Lin, Cheng-Wen Lin, Hui-Ju Lin, Fu-Tong Liu, Lei Wan
Obesity is a significant risk factor for various diseases. It is a clinical condition caused by the excessive accumulation of fat, which has a negative impact on human health. Galactin-12 is an adipocyte-expressed protein and possesses adipocyte-inducing activity. We investigated the expression level of candidate proteins involved in galactin-12-mediated adipocyte differentiation pathway. We performed a high-throughput screening assay to monitor galectin-12 promoter activity using 105 traditional Chinese herbs...
2018: American Journal of Chinese Medicine
Bo Zhou, Zhihui Jiang, Xinping Li, Xiaoying Zhang
The mechanism of ethanol-induced hepatotoxicity was complicated, accompanied by the over-expressions of the cytochrome P450 2E1 (CYP2E1), heat shock protein 70 (Hsp70) and the nuclear factor specificity protein 1 (SP1). Kaempferol (Kaem) could protect the ethanol-induced hepatotoxicity likely by inhibiting the CYP2E1 expression and activity. This study investigated the protective mechanism(s) of kaempferol on ethanol-induced toxicity by dynamic alteration of SP1, Hsp70 and CYP2E1 among the nucleus and different organelles in hepatocytes...
2018: American Journal of Chinese Medicine
Hyun Jong Kim, Yu Ran Nam, Joo Hyun Nam
Flos Magnoliae (FM, Chinese name: Xin-yi) is an oriental medicinal herb commonly used for symptomatic relief from allergic rhinitis, sinusitis, and headache, including in traditional Chinese and Korean medicine formulations. FM inhibits histamine release from mast cells and cytokine secretion from T cells. However, the mechanism of action of FM on the anoctamin-1 (ANO1) ion channel, which is responsible for nasal hypersecretion in allergic rhinitis, has not been elucidated. Therefore, in this study, we investigated the effect of a 30% ethanolic extract of FM (FMEtOH ) and its chemical constituents on ANO1 activity...
2018: American Journal of Chinese Medicine
Yu Xu, Hor-Yue Tan, Sha Li, Ning Wang, Yibin Feng
Panax notoginseng (P. notoginseng) is a well-known and commonly used Chinese herbal medicine in Asian countries. As one of the major species in the Panax genus, it has a distinct chemical composition and medical application compared with other species. P. notoginseng attracts attention and interest due to its potential therapeutic effects not only on blood diseases, but also other kinds of human chronic disorders. This paper critically reviewed the latest advance of knowledge on the pharmacological effects of P...
2018: American Journal of Chinese Medicine
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