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Acta Medica Indonesiana

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https://www.readbyqxmd.com/read/28790235/the-challenge-in-diagnosis-and-current-treatment-of-chronic-thromboembolic-pulmonary-hypertension
#1
Anggoro Budi Hartopo, Lucida Kris Dinarti, Abdul S Wahab
Chronic thromboembolic pulmonary hypertension (CTEPH) is currently underdiagnosis and consequently undertreatment in the clinical practice. A deficient in diagnostic modality and treatment availability especially in developing countries makes the CTEPH diagnosis unlikely to confirm. However, high index of clinical suspicion of CTEPH will lead to proper diagnosis and correct treatment  with significant reduction in morbidity and mortality. Left untreated, the mean survival time is 6.8 years and the three year mortality rate may be as high as 90 %...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790234/fixed-dose-combination-antituberculosis-therapy-as-a-risk-factor-for-tuberculosis-recurrence-an-evidence-based-case-report
#2
Arvin Pramudita, Cleopas M Rumende, Ardi Findyartini
BACKGROUND: a patient with a history of tuberculosis (TB) has a risk up to 27% to develop recurrence within 2 years after being cured. Indonesia itself has more than 7,500 recurrent cases annually, regardless of reinfection or relapse. This is an important problem, as recurrent TB is associated with lower cure rates with the anti-TB therapy and higher risk of developing drug resistance. Some risk factors for this recurrence are smoking, poor treatment adherence, low economic status, and weak immune status...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790233/functional-dyspepsia-with-helicobacter-pylori-infection
#3
Rabbinu Rangga Pribadi, Ari Fahrial Syam, Ening Krisnuhoni
Helicobacter pylori infection is commonly found worldwide. In Indonesia, the prevalence of H. pylori infection is 22.1%. The bacteria are responsible for gastritis, peptic ulcer disease (PUD), and gastric cancer.Helicobacter pylori may also has a role in functional dyspepsia. Diagnostic approach consists of noninvasive and invasive examinations. One of the invasive strategy is upper gastrointestinal (UGI) endoscopy and gastric mucosa biopsy.
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790232/corneal-sensitivity-as-a-potential-marker-of-diabetic-neuropathy
#4
Ratna Sitompul
Diabetes mellitus (DM) is a complex and chronic metabolic disorder leading to many complications. One of the most common complications of DM is diabetic neuropathy. There are many studies exploring corneal sensitivity as a potential marker of diabetic neuropathy. This review aims to explore association between corneal sensitivity and diabetic neuropathy. In diabetic neuropathy, corneal sensitivity is impaired due to low level of corneal nerve trophic factors, impaired sensory nerve fibers, and lost communication of dendtritic cell...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790231/inflammation-immunity-and-hypertension
#5
Arisya Agita, M Thaha Alsagaff
The immune system, inflammation and hypertension are related to each other. Innate and adaptive immunity system triggers an inflammatory process, in which blood pressure may increase, stimulating organ damage. Cells in innate immune system produce ROS, such as superoxide and hydrogen peroxide, which aimed at killing pathogens. Long-term inflammation process increases ROS production, causing oxidative stress which leads to endothelial dysfunction. Endothelial function is to regulate blood vessel tone and structure...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790230/ventilator-associated-pneumonia-vap-in-a-patient-with-guillain-barre-syndrome
#6
Anti Dharmayanti, Dalima Astrawinata
A 46-year-old man was admitted to ICU with a diagnosis at the time of admission of Guillain Barre Syndrome (GBS) and sepsis due to suspected Ventilator-Associated Pneumoniae (VAP). Specimens for the following laboratory workup were inquired, i.e. complete blood count, culture and resistance workup using specimens obtained from the tip of suction pipe, urinalysis and urine culture, blood culture and resistance, procalcitonin and lactate levels. Neutrophilia was found along with increased procalcitonin and lactate levels, which supported the sepsis diagnosis...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790229/autoimmune-disease-with-cardiac-valves-involvement-libman-sacks-endocarditis
#7
Eka Ginanjar, Yulianto Yulianto
This case study aim to evaluate the response of steroid treatment for autoimmune endocarditis. Valvular heart disease is relatively rising in both congenital and acquired cases, but the autoimmune endocarditis remains rare. In this case, a 34 year old woman with clinical manifestation resembling systemic lupus erythematosus (SLE) is diagnosed with Libman-sacks Endocarditis. After six months of steroid treatment, her clinical manifestations and heart structure improved.
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790228/association-between-serum-uric-acid-and-non-alcoholic-fatty-liver-disease-a-meta-analysis
#8
Guntur Darmawan, Laniyati Hamijoyo, Irsan Hasan
BACKGROUND: non-alcoholic fatty liver disease (NAFLD) is known to be associated with some metabolic disorders. Recent studies suggested the role of uric acid in NAFLD through oxidative stress and inflammatory process. This study is aimed to evaluate the association between serum uric acid and NAFLD. METHODS: a systematic literature review was conducted using Pubmed and Cochrane library. The quality of all studies was assessed using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790227/evaluation-of-acoustic-radiation-force-impulse-arfi-for-fibrosis-staging-in-chronic-liver-diseases
#9
Rino Alvani Gani, Irsan Hasan, Andri Sanityoso, Cosmas Rinaldi A Lesmana, Juferdy Kurniawan, Chyntia Olivia Maurine Jasirwan, Kemal Fariz Kalista, Lutfie Lutfie
BACKGROUND: acoustic radiation force impulse (ARFI) is a new proposed noninvasive method for liver fibrosis staging. Integrated with B-mode ultrasonography, ARFI can be used to assess liver tissue condition. However its diagnostic accuracy is still being continuously evaluated. Also, there is lack of data regarding the utilization of ARFI in our population. This study aimed to evaluate the diagnostic value of ARFI as an alternative noninvasive modality for fibrosis staging in chronic hepatitis B and hepatitis C patients in our population...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790226/effect-of-metformin-on-handgrip-strength-gait-speed-myostatin-serum-level-and-health-related-quality-of-life-a-double-blind-randomized-controlled-trial-among-non-diabetic-pre-frail-elderly-patients
#10
Purwita Wijaya Laksmi, Siti Setiati, Tirza Z Tamin, Pradana Soewondo, Wasilah Rochmah, Nafrialdi Nafrialdi, Joedo Prihartono
BACKGROUND: sarcopenia contributes to the development of frailty syndrome. Frailty syndrome is potentially improved by modifying insulin resistance, inflammation, and myostatin level. This study is aimed to investigate the effect of metformin on handgrip strength, gait speed, myostatin serum level, and health-related quality of life (HR-QoL) among non-diabetic pre-frail elderly patients. METHODS: a double blind randomized controlled trial study was conducted on non-diabetic elderly outpatients aged ≥ 60 years with pre-frail status based on phenotype and/ or index criteria (Cardiovascular Health Study and/ or Frailty Index 40 items) consecutively recruited from March 2015 to June 2016 at Cipto Mangunkusumo Hospital...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790225/diagnostic-performance-of-afternoon-urine-osmolality-to-assess-optimal-hydration-status-in-an-adult-healthy-population
#11
Ni Made Hustrini, Parlindungan Siregar, Ginova Nainggolan, Kuntjoro Harimurti
BACKGROUND: optimal hydration represents adequate total daily fluid intake to compensate for daily water losses, ensure adequate urine output to reduce the risk of urolithiasis and renal function decline, and also avoid the production of arginine vasopressin (AVP). Twenty-four-hour urine osmolality has been used to assess hydration status, but it is challenging because of the possibility of spilling urine and limitation of daily activities. This study is aimed to determine the performance of the afternoon urine osmolality to assess the optimal hydration status compared with 24-hour urine osmolality...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790224/comparison-of-glucosamine-chondroitin-sulfate-with-and-without-methylsulfonylmethane-in-grade-i-ii-knee-osteoarthritis-a-double-blind-randomized-controlled-trial
#12
Andri M T Lubis, Carles Siagian, Erick Wonggokusuma, Aldo F Marsetyo, Bambang Setyohadi
BACKGROUND: Glucosamine, chondroitinsulfate are frequently used to prevent further joint degeneration in osteoarthritis (OA). Methylsulfonylmethane (MSM) is a supplement containing organic sulphur and also reported to slow anatomical joint progressivity in the knee OA. The MSM is often combined with glucosamine and chondroitin sulfate. However, there are controversies whether glucosamine-chondroitin sulfate or their combination with methylsulfonylmethane could effectively reduce pain in OA...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790223/the-effect-of-psychological-stress-on-mucosal-il-6-and-helicobacter-pylori-activity-in-functional-dyspepsia
#13
Eryati Darwin, Arina Widya Murni, Adnil E Nurdin
BACKGROUND: pathophysiology of functional dyspepsia remains poorly understood. Many factors such as gastric motility disorder, visceral hypersensitivity, Helicobacter pylori (Hp) infection, psychological stress and excessive gastric acid secretion play roles in this symptom. Psychological stress may promote peptic ulcer and has an effect on ulcers-associated Hp. This study aimed to determine Helicobacter pylori activity and expression of mucosal IL-6 and their association with psychological stress...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790222/prevalence-and-profile-of-fibrosis-in-diabetic-patients-with-non-alcoholic-fatty-liver-disease-and-the-associated-factors
#14
Ignatius Bima Prasetya, Irsan Hasan, Wismandari Wisnu, Cleopas Martin Rumende
BACKGROUND: the risk of Non-Alcoholic Fatty Liver Disease (NAFLD) is increasing in patients with type-2 diabetes. Prevalence and factors related to the increased risk of NAFLD in diabetic patients in Indonesia has never been studied before. Data regarding the profile of fibrosis in the population has also been unknown. This study aimed to identify the difference on the profile of diabetic patients with and without NAFLD as well as the degree of fibrosis. METHODS: the study was conducted using a cross-sectional method in type-2 diabetic patients who were treated at the outpatient clinic of endocrinology and metabolic division in Cipto Mangunkusumo Hospital...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790221/fat-and-cardiometabolic-risk-burden
#15
Dyah Purnamasari
No abstract text is available yet for this article.
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450659/recent-management-of-patients-with-advanced-epidermal-growth-factor-receptor-mutation-non-small-cell-lung-cancer-role-of-afatinib-and-lesson-learned-for-developing-countries
#16
Zulkifli Amin, Vito Filbert Jayalie, Wulyo Rajabto
Lung cancer is a devastating disease with a high incidence, mortality and morbidity rate, especially in developing countries. Conventional treatment with cytotoxic chemotherapy has some limitations attributed to chemoresistance and toxicity. Recent advances have shown that first generation Tyrosine Kinase Inhibitor (TKI), Gefitinib and Erlotinib, and the newest available second generation Tyrosine Kinase Inhibitor (TKI), Afatinib, have the potential to be an option in the management of patients with epidermal growth factor receptor/ EGFR mutation positive advanced/ metastatic non-small cell lung cancer...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450658/the-role-of-docetaxel-in-non-castrate-resistant-metastatic-prostate-cancer-an-evidence-based-case-report
#17
Fakhri Rahman, Harrina Erlianti Rahardjo, Stefanus Cahyo Ariwicaksono, Hafizar Hafizar, Muhammad Gozali Arif Sembiring, Rendy Andika, Richman Patandung, Septiani Hidianingsih, Stevano L Hotasi
AIM: to learn the role of docetaxel in non-castrate resistant prostate cancer patient. METHODS: literature search was conducted to find relevant study comparing the combination of docetaxel and androgen deprivation therapy (ADT) to ADT alone in non-castrate resistant prostate cancer using PubMed, Cohrane Library, Proquest, EBSCO, and Scopus database. Quality assessment of studies was done using Bond University Rapid Critical Appraisal of a Systematic Review. RESULTS: we found 494 studies from literature search, but only two studies were included in final selection...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450657/parathyroid-adenoma-in-a-young-female-presenting-multiple-fractures-and-postoperative-hungry-bone-syndrome
#18
Hari Hendarto, Laurentius A Pramono, Dante S Harbuwono, Em Yunir, Imam Subekti
A young 18-year-old female patient with general bone pain and history of multiple fractures brought her to our medical attention. Laboratory work showed hypercalcemia and high parathyroid hormone levels in the blood. Radiograph imaging revealed severe scoliosis with multiple vertebrae fractures with decreased bone mineral density. Sestamibi showed parathyroid adenoma. This case emphasizes the importance of maintaining a primary hyperparathyroidism as a differential diagnosis when a young patient presents with a multiple pathologic fractures history...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450656/regulatory-t-cell-immunity-in-atherosclerosis
#19
Hilman Zulkifli Amin, Naoto Sasaki, Ken-Ichi Hirata
Atherosclerosis is a chronic inflammatory disorder involving innate and adaptive immunity process. Effector T cell (Teff) responses promote atherosclerotic disease, whereas regulatory T cells (Tregs) have been shown to play a protective role against atherosclerosis by down-regulating inflammatory responses which include multiple mechanisms. Compelling experimental data suggest that shifting the Treg/Teff balance toward Tregs may be a possible therapeutic approach for atherosclerotic disease, although the role of Tregs in human atherosclerotic disease has not been fully elucidated...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450655/riedel-s-lobe-clinical-importance-of-a-rare-variant-in-liver-morphology
#20
Juferdy Kurniawan, Dewi Anggraeni, Esthika Dewiasty, Lutfie Lutfie
Riedel's lobe is a normal variant form of right liver lobe rarely found. Here we report a case of 38 years old female with an incidental finding not revealed in physical examination, but then known to have hepatomegaly by gynecological ultrasonography. Diagnosis of Riedel's lobe was strengthened by similar results on hepatobiliary ultrasonography, abdominal MRI, and diagnostic laparoscopy. Our patient was discharged and had follow up examination three months later. Knowledge regarding this anomaly is essential to be understood because the finding of accessory liver lobe does not always remain asymptomatic as in our patient, but rather can be related to significant clinical complication...
January 2017: Acta Medica Indonesiana
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