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Acta Medica Indonesiana

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https://www.readbyqxmd.com/read/28450659/recent-management-of-patients-with-advanced-epidermal-growth-factor-receptor-mutation-non-small-cell-lung-cancer-role-of-afatinib-and-lesson-learned-for-developing-countries
#1
Zulkifli Amin, Vito Filbert Jayalie, Wulyo Rajabto
Lung cancer is a devastating disease with a high incidence, mortality and morbidity rate, especially in developing countries. Conventional treatment with cytotoxic chemotherapy has some limitations attributed to chemoresistance and toxicity. Recent advances have shown that first generation Tyrosine Kinase Inhibitor (TKI), Gefitinib and Erlotinib, and the newest available second generation Tyrosine Kinase Inhibitor (TKI), Afatinib, have the potential to be an option in the management of patients with epidermal growth factor receptor/ EGFR mutation positive advanced/ metastatic non-small cell lung cancer...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450658/the-role-of-docetaxel-in-non-castrate-resistant-metastatic-prostate-cancer-an-evidence-based-case-report
#2
Fakhri Rahman, Harrina Erlianti Rahardjo, Stefanus Cahyo Ariwicaksono, Hafizar Hafizar, Muhammad Gozali Arif Sembiring, Rendy Andika, Richman Patandung, Septiani Hidianingsih, Stevano L Hotasi
AIM: to learn the role of docetaxel in non-castrate resistant prostate cancer patient. METHODS: literature search was conducted to find relevant study comparing the combination of docetaxel and androgen deprivation therapy (ADT) to ADT alone in non-castrate resistant prostate cancer using PubMed, Cohrane Library, Proquest, EBSCO, and Scopus database. Quality assessment of studies was done using Bond University Rapid Critical Appraisal of a Systematic Review. RESULTS: we found 494 studies from literature search, but only two studies were included in final selection...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450657/parathyroid-adenoma-in-a-young-female-presenting-multiple-fractures-and-postoperative-hungry-bone-syndrome
#3
Hari Hendarto, Laurentius A Pramono, Dante S Harbuwono, Em Yunir, Imam Subekti
A young 18-year-old female patient with general bone pain and history of multiple fractures brought her to our medical attention. Laboratory work showed hypercalcemia and high parathyroid hormone levels in the blood. Radiograph imaging revealed severe scoliosis with multiple vertebrae fractures with decreased bone mineral density. Sestamibi showed parathyroid adenoma. This case emphasizes the importance of maintaining a primary hyperparathyroidism as a differential diagnosis when a young patient presents with a multiple pathologic fractures history...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450656/regulatory-t-cell-immunity-in-atherosclerosis
#4
Hilman Zulkifli Amin, Naoto Sasaki, Ken-Ichi Hirata
Atherosclerosis is a chronic inflammatory disorder involving innate and adaptive immunity process. Effector T cell (Teff) responses promote atherosclerotic disease, whereas regulatory T cells (Tregs) have been shown to play a protective role against atherosclerosis by down-regulating inflammatory responses which include multiple mechanisms. Compelling experimental data suggest that shifting the Treg/Teff balance toward Tregs may be a possible therapeutic approach for atherosclerotic disease, although the role of Tregs in human atherosclerotic disease has not been fully elucidated...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450655/riedel-s-lobe-clinical-importance-of-a-rare-variant-in-liver-morphology
#5
Juferdy Kurniawan, Dewi Anggraeni, Esthika Dewiasty, Lutfie Lutfie
Riedel's lobe is a normal variant form of right liver lobe rarely found. Here we report a case of 38 years old female with an incidental finding not revealed in physical examination, but then known to have hepatomegaly by gynecological ultrasonography. Diagnosis of Riedel's lobe was strengthened by similar results on hepatobiliary ultrasonography, abdominal MRI, and diagnostic laparoscopy. Our patient was discharged and had follow up examination three months later. Knowledge regarding this anomaly is essential to be understood because the finding of accessory liver lobe does not always remain asymptomatic as in our patient, but rather can be related to significant clinical complication...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450654/left-circumflexus-coronary-artery-total-occlusion-with-clinical-presentation-as-nstemi-and-acute-pulmonary-oedema
#6
Budi Yuli Setianto, Nahar Taufiq, Heri Hernawan
Current guidelines for the management of patients with acute coronary syndromes (ACSs) focus on the electrocardiogram to divide patients into ST-elevation acute myocardial infarction (STEMI) or non-ST-elevation acute myocardial infarction (NSTEMI)/unstable angina (UA). Patients with STEMI in the earliest time will receive reperfusion therapy to destruct occlusive thrombus. An ST segment elevation is the 'sine qua non' for diagnosing acute total coronary occlusion causing transmural myocardial infarction. Left circumflex coronary artery (LCx) occlusion is often categorized as NSTEMI because of the absence of significant ST-elevation on the 12 lead standard electrocardiogram...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450653/prediction-of-wound-healing-in-diabetic-foot-ulcers-an-observational-study-in-tertiary-hospital-in-indonesia
#7
Pradana Soewondo, Slamet Suyono, Mpu Kanoko Sastrosuwignyo, Alida R Harahap, Bambang Sutrisna, Lukman H Makmun
AIM: to evaluate the role of clinical characteristics, functional markers of vasodilation, inflammatory response, and atherosclerosis in predicting wound healing in diabetic foot ulcer. METHODS: a cohort study (February - October 2010) was conducted from 40 subjects with acute diabetic foot ulcer at clinical ward of Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia. Each subject underwent at least two variable measurements, i.e. during inflammatory phase and proliferation phase...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450652/concordance-between-reticulocyte-hemoglobin-equivalent-and-reticulocyte-hemoglobin-content-in-ckd-patients-undergoing-hemodialysis
#8
Riadi Wirawan, Ailinda Theodora Tedja, Fify Henrika, Aida Lydia
AIM: to evaluate the correlation and the concordance between reticulocyte hemoglobin equivalent (RET-He) and reticulocyte hemoglobin content (CHr) as well as to obtain the cut-off value of RET-He as the target of iron supplementation in chronic kidney disease (CKD) patients undergoing hemodialysis. METHODS: a cross-sectional study was performed using K3EDTA-anticoagulated peripheral blood samples collected from 106 CKD patients undergoing routine hemodialysis. The samples were then analyzed using both Sysmex XN-2000 and Siemens ADVIA 2120i for RET-He and CHr analysis...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450651/the-immunogenicity-and-safety-of-cyd-tetravalent-dengue-vaccine-cyd-tdv-in-children-and-adolescents-a-systematic-review
#9
Raksheeth Agarwal, Mardiastuti H Wahid, Oliver E Yausep, Sharon H Angel, Angga W Lokeswara
AIM: to assess the immunogenicity and safety of CYD-tetravalent dengue vaccine (CYD-TDV) in children. METHODS: comprehensive literature searches were conducted on various databases. Randomized-controlled trials on children with CYD-TDV as intervention were selected based on inclusion and exclusion criteria. Data extracted from selected trials included safety of vaccine and immunogenicity in terms of Geometric Mean Titres (GMT) of antibodies. RESULTS:   six clinical trials were selected based on preset criteria...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450650/y-chromosomal-microdeletion-in-idiopathic-azoospermic-and-severe-oligozoospermic-indonesian-men
#10
Ponco Birowo, Donny Eka Putra, Mewahyu Dewi, Nur Rasyid, Akmal Taher
AIM: to detect Y-chromosomal microdeletion in Indonesian men with azoospermia or severe oligozoospermia using multiplex PCR. METHODS: we performed 2 multiplex PCR amplifications of the Azoospermia Factor (AZF) region in 71 men. Criteria for including a patient were fulfilled if they presented with azoospermia or severe oligozoospermia, with or without additional abnormalities of sperm motility or of head morphology, raised or normal levels of FSH, normal levels of LH and testosterone, and with no evidence of testicular tumors or other abnormalities...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450649/validity-and-reliability-of-the-indonesian-version-of-sf-36-quality-of-life-questionnaire-on-patients-with-permanent-pacemakers
#11
Simon Salim, Muhammad Yamin, Idrus Alwi, Siti Setiati
AIM: to construct and validate Indonesian version of SF-36. METHODS: this is a cross-sectional study, which consist of 2 stages process: 1) language and cultural adaption; and 2) validity and reliability evaluation. We evaluated 32 pacemaker patients during language and cultural adaptation stage and 20 pacemaker patients during validity and reliability evaluation stages from September 2014 to August 2015. We followed cross-cultural adaptation guideline to produce Indonesian version of the questionnaire...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450648/the-validity-and-reliability-test-of-the-indonesian-version-of-gastroesophageal-reflux-disease-quality-of-life-gerd-qol-questionnaire
#12
Laura A Siahaan, Ari F Syam, Marcellus Simadibrata, Siti Setiati
AIM: to obtain a valid and reliable GERD-QOL questionnaire for Indonesian application. METHODS: at the initial stage, the GERD-QOL questionnaire was first translated into Indonesian language and the translated questionnaire was subsequently translated back into the original language (back-to-back translation). The results were evaluated by the researcher team and therefore, an Indonesian version of GERD-QOL questionnaire was developed. Ninety-one patients who had been clinically diagnosed with GERD based on the Montreal criteria were interviewed using the Indonesian version of GERD-QOL questionnaire and the SF 36 questionnaire...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28450647/translation-and-adaptation-of-foreign-questionnaire-the-first-step-should-be-done-before-used
#13
Siti Setiati
No abstract text is available yet for this article.
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143997/targeted-therapy-for-metastatic-renal-cell-carcinoma
#14
REVIEW
Andika Afriansyah, Agus Rizal Ah Hamid, Chaidir A Mochtar, Rainy Umbas
In the past 10 years, recent development of targeted therapy in metastatic renal cell carcinoma (mRCC) has provided a new hope and significantly enhanced the prognosis of the disease. Three class of targeted therapy were developed, including multi-targeted tyrosine kinase inhibitors (TKI), the mammalian target of rapamycin (mTOR) complex-1 kinase inhibitors, and the humanized antivascular endothelial growth factor (VEGF) monoclonal antibody. Hence, the objective of this article was to critically examine the current evidence of targeted therapy treatment for patients with mRCC...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143996/the-role-of-probiotic-in-reducing-hepatic-inflammation-among-nafld-patients-an-evidence-based-case-report
#15
Alvin Nursalim, Ummi Ulfah Madina, Cosmas Rinaldi A Lesmana
AIM: to know the effectiveness of probiotic in reducing hepatic inflammation among non-alcoholic fatty liver disease (NAFLD) patients. METHODS: we performed literature searching regarding the potential role of probiotic in reducing hepatic inflammation among NAFLD patients. RESULTS: six articles were finally critically appraised. All six studies had good validity and importance. These studies unanimously reported that probiotic is useful in reducing hepatic inflammation, and liver fat content...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143995/ebstein-anomaly-in-pregnancy
#16
Lusiani Rusdi, Syahrir Azizi, Christopher Suwita, Astrid Karina, Sally A Nasution
A 27-year-old primiparous woman with 28 weeks gestational age was admitted to our hospital with worsening shortness of breath. She was diagnosed with Ebstein's anomaly three years ago, but preferred to be left untreated. The patient was not cyanotic and her vital signs were stable. Her ECG showed incomplete RBBB and prolonged PR-interval. Blood tests revealed mild anemia. Observation of two-dimensional echo with color flow Doppler study showed Ebstein's anomaly with PFO as additional defects, EF of 57%, LV and LA dilatation, RV atrialization, severe TR, and moderate PH with RVSP of 44...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143994/intra-uterine-growth-retardation-and-development-of-hypertension
#17
REVIEW
Haerani Rasyid, Syakib Bakri
Low birth weight (LBW) is defined as a birth weight of a liveborn infant of <2,500 gram. In developed countries, LBW is commonly caused by preterm birth; while in developing countries, it is mostly due to intrauterine growth retardation. The concept of developmental origins of adult diseases, particularly on late-onset diseases such as hypertension and kidney disease, implies that there is a correlation between intrauterine milieu, intrauterine growth retardation, premature birth and infant feeding. The 'fetal origin hypothesis' suggests that metabolic diseases are directly related to poor nutritional status in early life...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143993/transcatheter-closure-of-patent-ductus-arteriosus-in-adolescents-and-adults-a-case-series
#18
Sukman Tulus Putra, Mulyadi M Djer, Nikmah S Idris, Sudigdo Sastroasmoro
During 11 years period from January 2005 to December 2015 there were 18 adolescent and adult patients  who underwent transcatheter closure of PDA using PDA Amplatzer Duct Occluder (ADO). There were 9 cases with age of 14 to 18 years and 9 cases with age of more than 18 years where the oldest case was 46 years old. Two cases were male and 16 cases were female. Prior to procedures, clinical assessment, ECG, chest x-ray and transthoracic echocardiography (TTE) were performed to confirm the diagnosis of PDA. The procedures of device implantation was performed under conscious sedation in adults and using general anesthesia in adolescents...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143992/an-east-asian-type-caga-helicobacter-pylori-infected-patient-with-clinical-manifestation-of-gastric-ulcer
#19
Yudith Annisa Ayu Rezkitha, Muhammad Miftahussurur, Iswan A Nusi, Ummi Maimunah, Pangestu Adi, Yoshio Yamaoka
We reported a male, 72 yo, Chinese ethnic with chief complaint black mushy defecation. Physical examination revealed pale on conjunctival palpebra which confirmed as anemia on complete blood count. Gastroduodenoscopy revealed a 3 mm ulcer at the antrum (Forrest stage III). H. pylori infection was positive based on five different test methods (urinary antibody tests, rapid urease test, culture, histology ad immunohistochemistry). Used polymerase chain reaction-based sequencing, we found the patient infected by CagA producing, East-Asian-type cagA and vacA s1m1-strain...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143991/short-term-survival-of-acute-respiratory-distress-syndrome-patients-at-a-single-tertiary-referral-centre-in-indonesia
#20
Zulkifli Amin, Hasna Afifah, Chrispian Oktafbipian Mamudi
AIM: to identify the 28-day short-term survival rate in patients with acute respiratory distress syndrome (ARDS). METHODS: this is a retrospective cohort study conducted at a tertiary referral hospital in Jakarta, Indonesia. We conducted the study for 10 months and data was extracted from medical records between October 2015 and August 2016. The primary end point of the study was 28-day short-term survival rate using the initial date of ARDS diagnosis as the index time...
October 2016: Acta Medica Indonesiana
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