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Acta Medica Indonesiana

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https://www.readbyqxmd.com/read/28143997/targeted-therapy-for-metastatic-renal-cell-carcinoma
#1
REVIEW
Andika Afriansyah, Agus Rizal Ah Hamid, Chaidir A Mochtar, Rainy Umbas
In the past 10 years, recent development of targeted therapy in metastatic renal cell carcinoma (mRCC) has provided a new hope and significantly enhanced the prognosis of the disease. Three class of targeted therapy were developed, including multi-targeted tyrosine kinase inhibitors (TKI), the mammalian target of rapamycin (mTOR) complex-1 kinase inhibitors, and the humanized antivascular endothelial growth factor (VEGF) monoclonal antibody. Hence, the objective of this article was to critically examine the current evidence of targeted therapy treatment for patients with mRCC...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143996/the-role-of-probiotic-in-reducing-hepatic-inflammation-among-nafld-patients-an-evidence-based-case-report
#2
Alvin Nursalim, Ummi Ulfah Madina, Cosmas Rinaldi A Lesmana
AIM: to know the effectiveness of probiotic in reducing hepatic inflammation among non-alcoholic fatty liver disease (NAFLD) patients. METHODS: we performed literature searching regarding the potential role of probiotic in reducing hepatic inflammation among NAFLD patients. RESULTS: six articles were finally critically appraised. All six studies had good validity and importance. These studies unanimously reported that probiotic is useful in reducing hepatic inflammation, and liver fat content...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143995/ebstein-anomaly-in-pregnancy
#3
Lusiani Rusdi, Syahrir Azizi, Christopher Suwita, Astrid Karina, Sally A Nasution
: A 27-year-old primiparous woman with 28 weeks gestational age was admitted to our hospital with worsening shortness of breath. She was diagnosed with Ebstein's anomaly three years ago, but preferred to be left untreated. The patient was not cyanotic and her vital signs were stable. Her ECG showed incomplete RBBB and prolonged PR-interval. Blood tests revealed mild anemia. Observation of two-dimensional echo with color flow Doppler study showed Ebstein's anomaly with PFO as additional defects, EF of 57%, LV and LA dilatation, RV atrialization, severe TR, and moderate PH with RVSP of 44...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143994/intra-uterine-growth-retardation-and-development-of-hypertension
#4
REVIEW
Haerani Rasyid, Syakib Bakri
Low birth weight (LBW) is defined as a birth weight of a liveborn infant of <2,500 gram. In developed countries, LBW is commonly caused by preterm birth; while in developing countries, it is mostly due to intrauterine growth retardation. The concept of developmental origins of adult diseases, particularly on late-onset diseases such as hypertension and kidney disease, implies that there is a correlation between intrauterine milieu, intrauterine growth retardation, premature birth and infant feeding. The 'fetal origin hypothesis' suggests that metabolic diseases are directly related to poor nutritional status in early life...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143993/transcatheter-closure-of-patent-ductus-arteriosus-in-adolescents-and-adults-a-case-series
#5
Sukman Tulus Putra, Mulyadi M Djer, Nikmah S Idris, Sudigdo Sastroasmoro
During 11 years period from January 2005 to December 2015 there were 18 adolescent and adult patients  who underwent transcatheter closure of PDA using PDA Amplatzer Duct Occluder (ADO). There were 9 cases with age of 14 to 18 years and 9 cases with age of more than 18 years where the oldest case was 46 years old. Two cases were male and 16 cases were female. Prior to procedures, clinical assessment, ECG, chest x-ray and transthoracic echocardiography (TTE) were performed to confirm the diagnosis of PDA. The procedures of device implantation was performed under conscious sedation in adults and using general anesthesia in adolescents...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143992/an-east-asian-type-caga-helicobacter-pylori-infected-patient-with-clinical-manifestation-of-gastric-ulcer
#6
Yudith Annisa Ayu Rezkitha, Muhammad Miftahussurur, Iswan A Nusi, Ummi Maimunah, Pangestu Adi, Yoshio Yamaoka
We reported a male, 72 yo, Chinese ethnic with chief complaint black mushy defecation. Physical examination revealed pale on conjunctival palpebra which confirmed as anemia on complete blood count. Gastroduodenoscopy revealed a 3 mm ulcer at the antrum (Forrest stage III). H. pylori infection was positive based on five different test methods (urinary antibody tests, rapid urease test, culture, histology ad immunohistochemistry). Used polymerase chain reaction-based sequencing, we found the patient infected by CagA producing, East-Asian-type cagA and vacA s1m1-strain...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143991/short-term-survival-of-acute-respiratory-distress-syndrome-patients-at-a-single-tertiary-referral-centre-in-indonesia
#7
Zulkifli Amin, Hasna Afifah, Chrispian Oktafbipian Mamudi
AIM: to identify the 28-day short-term survival rate in patients with acute respiratory distress syndrome (ARDS). METHODS: this is a retrospective cohort study conducted at a tertiary referral hospital in Jakarta, Indonesia. We conducted the study for 10 months and data was extracted from medical records between October 2015 and August 2016. The primary end point of the study was 28-day short-term survival rate using the initial date of ARDS diagnosis as the index time...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143990/microbiota-composition-hsp70-and-caspase-3-expression-as-marker-for-colorectal-cancer-patients-in-aceh-indonesia
#8
Fauzi Yusuf, Syafruddin Ilyas, Harun Al Rasyid Damanik, Fatchiyah Fatchiyah
AIM: to investigate the relationship between microbiota composition with HSP70 and Caspase-3 expressions in colon tissue as an initial study to develop the candidate for early detection of colorectal cancer for Indonesian patients. METHODS: this is a cross-sectional study on 32 patients undergoing colonoscopy; 16 patients of colorectal cancer (CRC) while the other 16 patients are not (colitis and internal hemorrhoid). The composition of microbiota in stool samples was examined using 16S rRNA Denaturing Gradient Gel Electrophoresis (DDGE) while expression of HSP70 was examined by immunohistochemistry and Caspase-3 by using Haematoxylin-Eosin(HE) staining to determine the morphological changes in colon tissue...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143989/mortality-related-factors-in-patients-with-malignant-obstructive-jaundice
#9
Juferdy Kurniawan, Irsan Hasan, Rino Alvani Gani, Marcellus Simadibrata
AIM: to obtain survival rate and mortality-related factors of malignant obstructive jaundice patients. METHODS: all medical records of obstructive jaundice inpatient at Cipto Mangunkusumo Hospital, Jakarta from January 2010 to December 2013 were reviewed retrospectively. The following factors were analyzed in terms of mortality: age, gender, sepsis, hypoalbumin, serum bilirubin level, serum CA 19-9 level, billiary drainage, non-ampulla Vateri carcinoma, and comorbid factors...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143988/parameters-affecting-length-of-stay-among-neurosurgical-patients-in-an-intensive-care-unit
#10
Phuping Akavipat, Jadsada Thinkhamrop, Bandit Thinkhamrop, Wimonrat Sriraj
AIM: to determine the predictive factors on the length of stay of neurosurgical patients in the ICU setting. METHODS: all patients admitted to the neurosurgical ICU between February 1 and July 31, 2011 were recruited. Patient demographics and clinical data for each variable were collected within 30 minutes of admission. The ICU length of stay was recorded and analyzed by linear regression model with statistical significance at p-value <0.05. RESULTS: there were 276 patients admitted, of whom 89...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143987/scoring-system-development-and-added-value-of-albuminuria-to-estimate-carotid-intima-media-thickness-cimt-in-type-2-diabetes-mellitus-patients
#11
Indra Wijaya, Em Yunir, Dharmeizar Dharmeizar, Ika Prasetya Wijaya, Siti Setiati
AIM: to develop a scoring system and measure the diagnostic added value of albuminuria to estimate CIMT. METHODS: cross-sectional study was done in Endocrine Outpatient Clinic Cipto Mangunkusumo Hospital between March-May 2012 in T2DM patients without history of cerebrocardiovascular event, CKD stage ≥ III, and smoking. Bivariate analysis and multivariate (logistic regression) analysis was done, followed by developing the scoring system. RESULTS: from 71 subjects, there were 67...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143986/expression-of-biomarkers-cxcr4-il11-ra-tff1-mlf1p-in-advanced-breast-cancer-patients-with-bone-metastatic-a-diagnostic-study
#12
Cosphiadi Irawan, Djumhana Atmakusumah, Nurjati Chaeranie Siregar, The Bin Tean, Lim Weng Kong, Ong Choon Kiat, Abdulmuthalib Abdulmuthalib, Alida Harahap, Muchtaruddin Mansyur
AIM: to analyze expression of biomarkers CXCR4, IL11-RA, TFF1 and MLF1P, and clinicopathology in advanced breast cancer patients with bone metastatic. METHODS: this is a cross-sectional study. Analysis was done against a total of 92 breast cancer patients, including 46 bone metastatic patients and 46 non-bone metastatic patients. Immunohistochemistry and microarray analysis was performed in 81 formalin fixed paraffin embedded (FFPE) samples from 81 patients were used...
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28143985/the-predictive-role-of-carotid-intima-media-thickness-what-is-the-clinical-relevance
#13
Dante Saksono Harbuwono
No abstract text is available yet for this article.
October 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/27847381/fasting-can-prevent-various-chronic-diseases
#14
Ari Fahrial Syam
No abstract text is available yet for this article.
July 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/27840362/current-diagnosis-and-management-of-thyroid-nodules
#15
REVIEW
Tjokorda Gde Dalem Pemayun
Thyroid nodules are frequently found. Although they are often palpable, many are found incidentally during unrelated radiographic studies. Ten to 15% of thyroid nodules represents thyroid malignancy. Clinician suc as an internist/endocrinologist have to  classify the nodule, stratify the risk of thyroid cancer, performed a diagnostic work-up, provide medical / non-surgical therapy, select candidates for surgery and provide appropriate follow-up that should last a lifetime. This article provide an up-date review of diagnostic approach and management of thyroid nodules, focusing on current algorithm in lights of the most recent published American Thyroid Association thyroid nodule and differentiated thyroid cancer management guidelines...
July 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/27840361/obesity-as-predictor-of-mortality-of-colorectal-cancer-an-evidence-based-case-report
#16
REVIEW
Matthew Billy, Hasna Sholihah, Kiwah Andanni, Margareth Ingrid Anggraeni, Saur M E J Siregar, Listya Tresnanti Mirtha
AIM: to determine all-cause mortality and cancer-spesific mortality of colorectal cancer patient with obesity. METHODS: a search was conducted on Pubmed, Proquest, Ebsco, Scopus, and Cochrane based on clinical query. The screening of title and abstract using inclusion and exclusion criteria, filtering double, and reading full text led to one useful article. This study, which is meta-analysis was critically appraised for its validity, importance and applicability...
July 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/27840360/giant-scrotal-hydrocele-and-bilateral-leg-lymphedema-as-clinical-manifestation-of-chronic-lymphatic-filariasis
#17
Indra Wijaya, Winfrey Pangestu
A 51-year-old male came with the complaint of recurrent swelling in the scrotum and legs. Swelling of the scrotum first appeared 17 years ago in the left scrotum approximately the same size as an apple and underwent surgery. However, 2 years after surgery, the swelling reemerged and gradually increase in size in both scrotums. Left leg swelling began to emerge 5 years ago followed by right leg 3 years after. The patient lives in Sarmi regency Papua province (endemic).
July 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/27840359/the-risk-factors-of-prostate-cancer-and-its-prevention-a-literature-review
#18
REVIEW
Noor Riza Perdana, Chaidir A Mochtar, Rainy Umbas, Agus Rizal Ah Hamid
This is a literature review study. Data was obtained from several literature reviews and journal resources that have correlation with the risk factors involved in PCa including age, ethnicity, family history, insulin-Like growth factor, sexually transmitted disease, obesity, smoking, alcohol consumption, vasectomy, and diet, and the prevention of PCa including soy, lycopene, green tea, supplementation, and exercise.Numerous epidemiologic studies have linked PCa risk to various factors, i.e. age, ethnicity, family history, insulin like-growth factors, lifestyle, diet, environmental and occupational exposures...
July 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/27840358/a-44-year-old-man-with-waldenstrom-macroglobulinemia-and-bilateral-maxillary-sinusitis
#19
Herman Bagus Trianto, Shinta Oktya Wardhani
Waldenstrom macroglobulinemia is a chronic, indolent, lymphoproliferative disorder, which is characterized by the presence of a high macroglobulin (IgM) level, elevated serum viscosity, and the presence of a lymphoplasmacytic infiltrate in the bone marrow. Clinical manifestations may be found due to the presence of IgM paraprotein and malignant lymphoplasmacytic cell infiltration of the bone marrow and other tissues. We reported a case of male patient with Waldenstrom macroglobulinemia and bilateral maxillary sinusitis...
July 2016: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/27840357/fasting-can-prevent-various-chronic-diseases
#20
Ari Fahrial Syam
No abstract text is available yet for this article.
July 2016: Acta Medica Indonesiana
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