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Gynecologic and Obstetric Investigation

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https://www.readbyqxmd.com/read/27883998/the-non-ergot-derived-dopamine-agonist-quinagolide-as-an-anti-endometriotic-agent
#1
Alpaslan Akyol, Ebru Kavak, Hadice Akyol, Şehmus Pala, Ferit Gürsu
AIM: The study aimed to investigate the efficacy of a dopamine agonist, quinagolide, on experimentally induced endometriosis in a rat model. METHODS: Twenty female Wistar rats were used in this experiment. Endometriosis was surgically induced by transplantation of autologous endometrial tissue. A second laparotomy was performed 4 weeks after the first one to assess the pre-treatment implant volumes, and peritoneal lavage with saline solution was performed to assess the peritoneal cytokine levels...
November 25, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27880944/opportunistic-salpingectomy-does-not-affect-ovarian-reserve-or-surgical-outcomes-in-patients-undergoing-laparoscopic-myomectomy
#2
Taejong Song, San-Hui Lee, Woo Young Kim, Eun Jin Heo, Tae-Joong Kim
OBJECTIVE: To determine whether opportunistic salpingectomy in patients undergoing laparoscopic myomectomy has any deleterious effects on ovarian reserve and surgical risk. STUDY DESIGN: We performed a retrospective review of patients who had no desire for future child bearing and who were undergoing laparoscopic myomectomy for symptomatic myomas at 4 institutions. Among them, 41 patients concurrently underwent opportunistic salpingectomy (the opportunistic salpingectomy group) and 65 patients did not undergo salpingectomy at the time of laparoscopic myomectomy (the no-salpingectomy group)...
November 24, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27875811/prospective-case-control-study-of-abnormal-bleeding-after-outpatient-corticosteroid-injection
#3
Elizabeth Suh-Burgmann, Jennifer Y Liu
OBJECTIVE: This study is aimed at evaluating the incidence of bleeding among women having outpatient corticosteroid injection compared to matched controls, using mailed surveys and electronic health records. STUDY DESIGN: Prospective survey study of women receiving outpatient corticosteroid injection for joint or back pain (cases) compared to women matched for visit, diagnosis of joint/back pain, and age, who did not receive an injection (controls). A survey was mailed 45 days following outpatient visit, inquiring about menstrual history, abnormal bleeding, and potential risk factors...
November 23, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27852078/clomiphene-citrate-versus-letrozole-for-ovarian-stimulation-in-therapeutic-donor-sperm-insemination
#4
Hady El Hachem, Roland Antaki, Camille Sylvestre, Isaac-Jacques Kadoch, Louise Lapensée, Pierre Emmanuel Bouet
AIM: To compare clomiphene citrate (CC) and letrozole for ovarian stimulation (OS) in therapeutic donor sperm insemination (TDI) cycles. METHODS: Retrospective cohort study between January 2011 and June 2014 at a University-affiliated private IVF clinic in Montreal, Canada. 257 normo-ovulatory women ≤40 years of age with no history of infertility undergoing 590 TDI cycles in the absence of a male partner (single women and same-sex couples) or azoospermia were included...
November 17, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27846619/identifying-gene-signature-for-the-detection-of-ovarian-cancer-based-on-the-achieved-related-genes
#5
Liangliang Wang, Lihua Wang, Ling Ma, Jingbo Liu, Shanshan Ma
BACKGROUND: The overall survival rate of ovarian cancer patients is still poor because of the difficulties encountered in detection, diagnosis and treatment. Here, we aim to systematically identify the genetic factors causing ovarian cancer and find the accurate diagnostic and therapeutic targets for ovarian cancer. METHODS: We collected the known archived ovarian cancer-related genes from the databases used as the investigated targets and employed the minimum redundancy maximum relevance and random forest classification to identify the novel ovarian cancer-related genes in addition to the known ones...
November 16, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27832646/the-impact-of-a-standardized-oral-multinutrient-supplementation-on-embryo-quality-in-in-vitro-fertilization-intracytoplasmic-sperm-injection-a-prospective-randomized-trial
#6
Kazem Nouri, Katharina Walch, Andrea Weghofer, Martin Imhof, Christian Egarter, Johannes Ott
The role of micronutrients in fertility has recently gained increased attention. We aimed to test the impact of a standardized, multinutrient supplementation on outcomes after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a pilot study. One hundred women undergoing IVF/ICSI were prospectively included and randomized to receive either a multinutrient supplementation named PROfertil® female that included folic acid, selenium, vitamin E, catechins, glycyrrhizin, diosgenin, damiana and omega-3-fatty acids (study group; n = 50), or 400 µg folic acid (control group; n = 50)...
November 11, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27820938/prevalence-and-symptomatic-burden-of-diagnosed-endometriosis-in-the-united-states-national-estimates-from-a-cross-sectional-survey-of-59-411-women
#7
Mahesh J Fuldeore, Ahmed M Soliman
BACKGROUND/AIMS: To estimate the prevalence of diagnosed endometriosis (DE) in women in the United States and assess the associated symptomatic burden. METHODS: An online, cross-sectional survey of women aged 18-49 years was conducted from August 6, 2012, through November 14, 2012. Survey data (weighted by age, race, education, income, geographical distribution, and propensity score) were used to estimate the prevalence and symptomatic burden of DE in women in the United States...
November 8, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27816976/detecting-endometriosis-in-adolescents-why-not-start-from-self-report-screening-questionnaires-for-adult-women
#8
Brecht Geysenbergh, Eline A F Dancet, Thomas D'Hooghe
BACKGROUND: Endometriosis in adolescent girls is often diagnosed after a long delay. This diagnostic delay can be associated with more advanced stages of endometriosis and with a higher likelihood of fertility problems at a later age. MATERIAL AND METHODS: A systematic review of literature and quality assessment was performed in order to identify questionnaires that were developed to identify adult women with endometriosis. Based on these questionnaires, specific questions that had been reported to be predictive for endometriosis were selected and included in a newly composed questionnaire with the aim to identify adolescents at risk of developing endometriosis...
November 5, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27816973/tachysystole-following-cervical-ripening-and-induction-of-labor-is-not-associated-with-adverse-outcomes
#9
James A Bofill, Marie M Darby, Javier Castillo, Sandip U Sawardecker, Everett F Magann, John C Morrison
PURPOSE: This study was aimed at determining if significant uterine tachysystole was associated with adverse fetal or neonatal outcomes during cervical ripening and induction of labor. METHODS: Women undergoing cervical ripening and subsequent labor induction (n = 905) were assessed for tachysystole, defined as ≥6 contractions in each of 2 consecutive 10-minute windows. Women with ≥3 episodes of tachysystole were compared to women with no tachysystole. RESULTS: Over a 5-year period, 70% of the 905 participants (n = 631) had no tachysystole, 143 had 1 or 2 episodes whereas 131 or 15% had ≥3 episodes (p = 0...
November 5, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27811474/abdominal-wall-endometriosis-myofibroblasts-as-a-possible-evidence-of-metaplasia-a-case-report
#10
Mohamed Gamal Ibrahim, Eleonore Delarue, Elene Abesadze, Matthias Haas, Jalid Sehouli, Vito Chiantera, Sylvia Mechsner
In this study, we report about a patient with extra-uterine endometriosis (EM) in the abdominal wall muscle with evident metaplasia based on the abundant alpha smooth muscle actin (ASMA)-expressing myofibroblasts. Laparotomy excision of the abdominal wall EM was done following ultrasonographic evidence of a hypodense swelling in the right rectus abdominis, which was confirmed by MRI. Immunohistochemistry staining for ASMA and collagen I was done, with the results confirming that endometriotic stromal cells expressed both...
November 4, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27794572/the-value-of-the-cerebroplacental-ratio-for-the-prediction-of-intrapartum-fetal-monitoring-in-low-risk-term-pregnancies
#11
Jing Liu, Guang Song, Ge Zhao, Tao Meng
AIM: The study aimed to investigate the use of fetal cerebroplacental ratio (CPR) to identify fetuses at high risk before labor due to the brain sparing phenomenon. MATERIALS AND METHODS: Four hundred and seventy-six singleton pregnancies were enrolled in this study. The CPR was recorded within 1 week of delivery and labor was managed according to local protocols and guidelines. Intrapartum and neonatal outcome details were recorded. RESULTS: The CPR values of fetuses subsequently presenting category III intrapartum electronic fetal monitoring (EFM) or category II EFM without improvement (category IIB EFM) or with progression to category III (category IIC EFM) were significantly lower...
October 29, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27771729/preoperative-18f-fluorodeoxyglucose-positron-emission-tomography-ct-in-prediction-of-uterine-risk-factors-and-lymph-node-metastasis-an-analysis-of-111-endometrioid-endometrial-cancer-patients
#12
Bahar Konuralp Atakul, Salih Taşkın, Çiğdem Soydal, Yavuz Emre Sükür, Alper Kahraman, Kazibe Koyuncu, Erkan İbiş, Firat Ortac
INTRODUCTION: This study evaluated the role of 18F-fluorodeoxyglucose (FDG) positron emission tomography/CT (PET/CT) in the detection of lymph node metastases and the association between uterine maximum standardized uptake values (SUVmax) and the histopathological features in endometrial cancer patients. MATERIALS AND METHODS: Patients with endometrioid endometrial cancer underwent preoperative 18F-FDG PET/CT imaging and were staged surgically. 18F-FDG PET/CT findings were compared with final pathology reports...
October 22, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27771710/bridge-suture-for-successful-mcdonald-emergency-cerclage
#13
Masaaki Tanaka, Yoshiaki Hori, Aya Shirafuji, Mitsunori Kato, Jyun Kato, Hiroto Kobayashi, Toru Tsuchida, Tsukasa Fukae
OBJECTIVES: To create awareness about a surgical technique termed bridge suture, which is performed as a pretreatment before a McDonald cerclage is performed on an emergency to treat severe cervical insufficiency. METHODS: Procedures for bridge suture were reviewed in detail and outcomes of 16 patients treated with bridge suture followed by McDonald cerclage were evaluated retrospectively. RESULTS: Using the bridge suture, the edges of uterine cervix were temporarily sutured and the external uterine os was closed, while the hourglass-shaped fetal membranes were concomitantly confined within the cervix; subsequently, a McDonald cerclage was performed...
October 22, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27736820/european-nationality-influence-in-the-management-of-squamous-cell-vulvar-cancer
#14
Sara Iacoponi, Ignacio Zapardiel
AIMS: Vulvar cancer is a rare disease. In western European countries, the incidence is 1.2 cases per 100,000 women/year. The aim of this study was to analyze the management and disease-free survival (DFS) of vulvar cancer among European countries. METHODS: An international multicenter retrospective study including patients diagnosed of squamous cell vulvar cancer was performed. Countries analyzed included Austria, Germany, Greece, Italy, Latvia, Lithuania, Poland, Portugal, Spain and Turkey...
October 14, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27710968/endometriotic-pain-is-associated-with-adenomyosis-but-not-with-the-compartments-affected-by-deep-infiltrating-endometriosis
#15
Maria Francesca Perelló, Maria Ángeles Martínez-Zamora, Ximena Torres, Jordina Munrós, Juan Balasch Cortina, Francisco Carmona
BACKGROUND: The identification of presurgical clinical markers may be helpful to allow the staging of endometriosis severity. It has been suggested that pain characteristics orientate the gynecologist about the anatomical involvement of endometriosis. The study was performed to analyze the correlation between pain symptoms and the anatomical location of endometriosis. METHODS: One hundred fifty-five consecutive patients with a complete removal of deep infiltrating endometriosis (DIE) were included...
October 7, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27705973/utility-of-three-dimensional-ultrasonography-to-assess-the-position-of-essure-tubal-occlusion-device-and-its-complications
#16
Covadonga Alvarez-Lopez, Javier De Santiago, Antonio Piñera, Roberto Rodriguez, Beatriz Herrero, Maria Herrera, Jaime Pillado, Ignacio Zapardiel
BACKGROUND: To determine the utility of three-dimensional (3D) sonography to control the position of hysteroscopic sterilizing device compared to hysterosalpingography (HSG). METHODS: A prospective observational study was carried out on 139 patients who underwent hysteroscopic tubal occlusion method between February 2012 and May 2013. Patients underwent 3D ultrasound scan to control device positioning, and they also underwent HSG as an additional control method...
October 6, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27701165/lung-ultrasound-pattern-is-normal-during-the-last-gestational-weeks-an-observational-pilot-study
#17
Erik Arbeid, Alessio Demi, Etrusca Brogi, Elisa Gori, Teresa Giusto, Gino Soldati, Luigi Vetrugno, Francesco Giunta, Francesco Forfori
BACKGROUND/AIMS: The normal lung ultrasound (US) pattern during a regular pregnancy has not been evaluated extensively in the current literature. Pregnancy-related changes in the respiratory tract affect maternal predisposition to several respiratory complications; consequently, it is important to differentiate between a physiologic pattern during pregnancy and a pathologic lung pattern, due to respiratory failure. The goal of our study was to assess the normal US lung pattern in women without known comorbidities in the last weeks of pregnancy...
October 5, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27684889/implementation-of-the-four-category-classification-of-cesarean-section-urgency-in-clinical-practice-a-prospective-study
#18
Francesco Maneschi, Desiree Biccirè, Giusi Santangelo, Seila Perrone, Alberto Scaini, Carmine Cosentino
PURPOSE: This study is aimed at investigating the clinical efficacy of the 4-category classification of urgent cesarean section. METHODS: Women giving birth from September 2012 to December 2014 were prospectively investigated. Urgency C-section categories were color-coded: red - maternal/fetal life threat; yellow - maternal/fetal compromise, not life-threatening; and green - early delivery necessary. Results were audited. RESULTS: A total of 4,754 women gave birth in the period considered, 1,313 (27...
September 30, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27655036/paget-s-disease-of-the-vulva-treated-with-imiquimod-case-report-and-systematic-review-of-the-literature
#19
Askin Dogan, Ziad Hilal, Harald Krentel, Cem Cetin, Lukas A Hefler, Christoph Grimm, Clemens B Tempfer
BACKGROUND: Extramammary Paget's disease of the vulva (EPDV) is a rare adenocarcinoma in situ of the vulvar skin and is often resected with involved margins due to its reticular growth pattern. Adjuvant treatment with the immunomodulator imiquimod may be suitable to avoid repeated and mutilating surgery. CASE PRESENTATION: We present the case of a 73-year-old woman with EPDV, initially treated with surgical resection and re-resection for involved margins. Final histology revealed Paget's disease of the left vulva with 8 cm in the largest diameter and again involved margins...
September 22, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27644043/circulating-fibronectin-and-plasminogen-activator-inhibitor-2-levels-as-possible-predictors-of-recurrent-placental-syndrome-an-exploratory-study
#20
Carmen A H Severens-Rijvers, Salwan Al-Nasiry, Chahinda Ghossein-Doha, Sara Marzano, Hugo Ten Cate, Bjorn Winkens, Marc A E Spaanderman, Louis L H Peeters
BACKGROUND/AIM: Placental syndromes (PS) are characterized by endothelial dysfunction complicating placental dysfunction. Possible markers for endothelial dysfunction and amount of trophoblast are fibronectin and plasminogen activator inhibitor-2 (PAI-2), respectively. We aimed (1) to determine whether in women with recurrent PS (rPS), this complication is preceded by deviating fibronectin- and PAI-2-levels, and (2) whether this is dependent on pre-pregnant plasma volume (PV). METHODS: In 36 former patients, we determined fibronectin- and PAI-2-levels in blood-samples collected preconceptionally and at 12-16 weeks in their next pregnancy...
September 20, 2016: Gynecologic and Obstetric Investigation
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