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Gynecologic and Obstetric Investigation

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https://www.readbyqxmd.com/read/29227976/progesterone-receptor-isoforms-nuclear-corepressor-1-and-steroid-receptor-coactivator-1-and-b-cell-lymphoma-2-and-akt-and-akt-phosphorylation-status-in-uterine-myomas-after-ulipristal-acetate-treatment-a-systematic-immunohistochemical-evaluation
#1
Guillaume E Courtoy, Jacques Donnez, Etienne Marbaix, Matilde Barreira, Mathieu Luyckx, Marie-Madeleine Dolmans
OBJECTIVE: To investigate whether ulipristal acetate (UPA) treatment modifies the expression of progesterone receptor (PR), its nuclear cofactors steroid receptor coactivator-1 (SRC1) and nuclear corepressor-1 (NCoR1), prosurvival factor B-cell lymphoma 2 (Bcl-2), and Akt in uterine myomas. PATIENTS: Prospective study of 59 women with symptomatic myomas undergoing myomectomy. Forty-two patients were treated preoperatively with UPA; the remaining 17 were not and they served as controls...
December 11, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29223999/two-years-follow-up-of-patients-with-abnormal-uterine-bleeding-after-insertion-of-the-levonorgestrel-releasing-intrauterine-system
#2
Numan Cim, Sunullah Soysal, Sena Sayan, Begum Yildizhan, Erbil Karaman, Orkun Cetin, Harun Egemen Tolunay, Recep Yildizhan
AIM: To evaluate the efficacy and safety of levonorgestrel-releasing intrauterine system (LNG-IUS) in the long-term treatment of heavy menstrual blood loss in women unrelated to intrauterine pathology. METHODS: One hundred and six parous women aged 33-48 years with recurrent heavy menstrual bleeding (HMB) participated in this study. The women were followed up for 24 months and were assessed for intensity of bleeding both for pre- and post-insertion periods. An LNG-IUS was inserted in each patient within 7 days of the start of menstrual flow...
December 8, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29183020/clinical-application-of-quantitative-foetal-fibronectin-for-the-prediction-of-preterm-birth-in-symptomatic-women
#3
Samara K Radford, Fabricio Da Silva Costa, Edward Araujo Júnior, Penelope M Sheehan
AIM: To evaluate the clinical application of the new Hologic quantitative foetal fibronectin (qfFN) bedside test for the prediction of spontaneous preterm birth (sPTB) in patients with symptoms suggestive of spontaneous threatened preterm labour (sPTL). METHODS: A prospective observational study with 154 pregnant women presenting signs and symptoms of sPTL was conducted. These women were subjected to a qfFN test between 22 and 35 weeks of gestation For each cut-off threshold, the ability to predict sPTB at within 14 days of conducting the test and <37 weeks was assessed by calculating the positive predictive value (PPV), negative predictive value (NPV), likelihood ratios, odds ratios, sensitivity, and specificity...
November 29, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29208846/evaluation-of-the-efficacy-of-ultrasound-guided-local-lauromacrogol-injection-combined-with-aspiration-for-cesarean-scar-pregnancy-a-novel-treatment
#4
Ze-Ying Chai, Li Yu, Man-Man Liu, Tong-Wei Zhu, Feng Qi
OBJECTIVES: To evaluate the efficacy of ultrasound-guided local lauromacrogol injection combined with aspiration for treating cesarean scar pregnancy (CSP). METHODS: From July 2016 to December 2016, 18 patients diagnosed with CSP were treated with ultrasound-guided local lauromacrogol injection combined with aspiration. Clinical data and outcome were analysed. RESULTS: All patients were treated successfully. The amount of bleeding ranged between 10 and 50 mL...
November 28, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29208847/effect-of-etanercept-on-the-success-of-assisted-reproductive-technology-in-patients-with-endometrioma
#5
Göğşen Önalan, Yusuf Aytaç Tohma, Hulusi Bülent Zeyneloğlu
AIMS: To determine the effects of a tumor necrosis factor inhibitor (etanercept) on pregnancy outcomes in patients with endometrioma who were treated with assisted reproductive technology. METHODS: Sixty-eight infertile patients who had endometrioma were included in our retrospective case-control study. We administered etanercept (Enbrel, 50 mg in 1 mL intramuscularly) to 19 patients on the second day of their previous menstrual cycle. All patients were treated with assisted reproductive technology...
November 24, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29156453/use-of-genetic-testing-after-abnormal-screening-ultrasound-a-descriptive-cohort-study
#6
Alessandra J Ainsworth, Michelle A Holman, Elisabeth Codsi, Myra Wick
BACKGROUND/AIMS: The study aimed to characterize the use of genetic testing after abnormal screening ultrasound. METHODS: We performed a retrospective review of patients undergoing genetic testing after abnormal ultrasound. Genetic evaluation consisted of noninvasive prenatal screening (NIPS) or amniocentesis. Classification of ultrasound findings, type of genetic testing, and results were collected. RESULTS: A total of 139 subjects underwent genetic evaluation after abnormal screening ultrasound...
November 20, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29141244/exploring-parental-expectations-and-experiences-around-gentle-and-standard-caesarean-section
#7
Jolien Onsea, Bernadette Bijnens, Siska Van Damme, Tim Van Mieghem
BACKGROUND/AIMS: "Gentle" or "natural" cesarean sections are implemented to improve parental satisfaction. The objective of this study was to investigate whether there is a need for adopting such a gentle approach. METHODS: We recruited those with low-risk pregnancies scheduled for elective cesarean delivery at term. Three questionnaires were administered to both partners: prior to delivery, 2-5 days after delivery, and 6 weeks postpartum. Questionnaires assessed the couple's expectations, fears, and satisfaction prior to and after cesarean section...
November 16, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29130987/relationship-between-ras-association-domain-family-protein-1a-promoter-methylation-and-the-clinicopathological-characteristics-in-patients-with-ovarian-cancer-a-systematic-meta-analysis
#8
Hong Wang, Manhua Cui, Shuangli Zhang, Jie He, Li Song, Ying Chen
BACKGROUND: To investigate the relationship between RAS association domain family protein 1A (RASSF1A) promoter methylation and the clinical features, and the survival of ovarian cancer patients. METHODS: A comprehensive literature search was conducted in the PubMed, Embase, EBSCO, and Cochrane Library databases. The overall ORs with their 95% CIs were calculated in this meta-analysis. RESULTS: Finally 17 relevant publications with 1,108 ovarian cancer samples were available for the current meta-analysis...
November 9, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29131023/evaluation-of-serum-nidogen-2-as-a-screening-and-diagnostic-tool-for-ovarian-cancer
#9
Haitham A Torky, Ahmed Sherif, Ashraf Abo-Louz, Mohamed Ali, Ali Ahmed, Ahmad Ali
INTRODUCTION: Ovarian cancer is a relatively common occurrence with the formation of a tumour in the ovaries and is the leading cause of death in the gynecological field. Despite enormous efforts, there are no successful screening methods developed until now to decrease mortality in this regard. AIM: To evaluate nidogen-2 as a new tumour marker combined with higher sensitivity, specificity and accuracy than carbohydrate antigen (CA-125) and Doppler ultrasound to improve early diagnosis of ovarian cancer...
November 7, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29131105/survival-rates-in-closed-and-open-vitrification-for-human-mature-oocyte-cryopreservation-a-meta-analysis
#10
Hyun Sik Youm, Jong-Ryeol Choi, Daesik Oh, Yong Ho Rho
BACKGROUND/AIMS: Survival of warmed oocytes is the first part and is one of the most important aspects of in vitro fertilization following oocyte cryopreservation. There is no definite conclusion about the difference in survival rates between closed and open vitrification for oocyte cryopreservation. This study aimed to investigate whether there is a difference in survival rates between closed and open vitrification for cryopreservation of human mature oocytes. METHODS: A literature search was performed using the MEDLINE, Cochrane Central Register of Controlled Trials, and Embase databases...
November 1, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29080885/roles-of-mifepristone-on-the-regulation-of-cytotoxic-lymphocytes-and-regulatory-t-cells
#11
Linxiang Liu, Feng Zhou, Jiale Qin, Zhida Qian, Lili Huang
OBJECTIVE: To investigate the immunologic function of mifepristone, which acts as a contraceptive drug at the level of the decidua. SETTING: In our hospital, 60 women (less than 63 days of amenorrhea) volunteered to terminate their pregnancies by the uterine suction evacuation method. Immunohistochemically, the transcription factor forkhead box P3 and granzyme B staining were performed to identify regulatory T cells and cytotoxic lymphocytes (CLs) in all operational subjects...
October 28, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29059671/polymorphisms-in-sex-hormone-metabolism-genes-and-risk-of-preeclampsia-in-taiyuan-china
#12
Ping Zhang, Hailan Yang, Yongliang Feng, Weiwei Wu, Shuzhen Li, Brian Thompson, Bingjie Xie, Pengge Guo, Mei Li, Ying Wang, Nan Zhao, Suping Wang, Yawei Zhang
OBJECTIVE: Aberrant synthesis and metabolism of sex hormone are likely to be associated with alterations in vascular function in preeclampsia (PE). The study aims to investigate whether single nucleotide polymorphisms (SNPs) in sex hormone-related genes are associated with PE. METHOD: We performed a nested case-control study including 436 pregnant women (203 PE and 233 healthy or normal pregnant women) to investigate associations between 96 SNPs in 28 sex hormone-related genes and risk of PE...
October 24, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29050014/a-real-life-analysis-of-reproductive-outcome-after-fertility-preservation-in-female-cancer-patients
#13
Sofie Hulsbosch, Martin Koskas, Carla Tomassetti, Petra De Sutter, Hans Wildiers, Patrick Neven, Thomas D'Hooghe, Frederic Amant
BACKGROUND: Fertility preservation before or during cancer treatment in young women has become an important health issue because of delayed motherhood and improved survival rates. This study evaluates the necessity and the efficacy of fertility preservation, with a focus on actual pregnancy wish and outcome after fertility preservation and cancer treatment. PATIENTS AND METHODS: All consecutive patients who received fertility preservation in 2 university referral centers before or during cancer treatment were included...
October 20, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29017160/role-of-molecular-biology-in-diagnosis-and-characterization-of-vulvo-vaginitis-in-clinical-practice
#14
Gilbert G G Donders, Jacques Ravel, Beatrice Vitali, Mihai G Netea, Andres Salumets, Magnus Unemo
The diagnosis of vulvo-vaginal complaints has always been enigmatic in obstetrics and gynecology. Patients with clear, pathognomonic symptoms end up with a proper diagnosis and treatment most of the time, but unfortunately we are now living in a world where women reach out to the Internet and readily get all information as to which disease their symptoms correspond to and also find the appropriate treatment "over-the-counter." Because of this trend, we as specialists are increasingly confronted with patients with complex and combined conditions...
October 10, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28982101/misoprostol-prior-to-diagnostic-office-hysteroscopy-in-the-subgroup-of-patients-with-no-risk-factors-for-cervical-stenosis-a-randomized-double-blind-placebo-controlled-trial
#15
Usama M Fouda, Khaled A Elsetohy, Hesham S Elshaer, Bahaa Eldin M Hammad, Mona M Shaban, Mohamed A Youssef, Ahmed T Hashem, Ahmed H Attia
AIMS: To assess the effectiveness of vaginal misoprostol in minimizing the pain perceived by patients with no risk factors for cervical stenosis (i.e., parous women of reproductive age who have no history of cesarean section or cervical surgery) during diagnostic office hysteroscopy. METHODS: A total of 100 patients with no risk factors for cervical stenosis were randomized to the misoprostol group (n = 50) or the placebo group (n = 50). In the misoprostol group, 2 misoprostol tablets (400 µg) were administered vaginally 12 h before office hysteroscopy...
October 6, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28957806/omission-of-a-bladder-flap-during-cesarean-birth-in-primiparous-women
#16
Berna Aslan Cetin, Begum Aydogan Mathyk, Sibel Barut, Yelda Zindar, Kerem Doga Seckin, Pinar Kadirogullari
AIMS: Creation of a bladder flap has traditionally been an integral surgical step of Cesarean birth, and the practicality of such a procedure to create a bladder flap is still highly debated. METHODS: A total of 208 patients undergoing a primary cesarean birth were randomized. Group 1 (bladder flap) had 101 patients and group 2 (omission of a bladder flap) had 100 patients. The primary outcome was the total operating time and secondary outcomes were postoperative urinary symptoms, bladder injury, postoperative urinary retention, and postoperative residual urine volume...
September 29, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28957798/changes-in-the-uterine-scar-during-the-first-year-after-a-caesarean-section-a-prospective-longitudinal-study
#17
Lucy F van der Voet, Inge P M Jordans, Hans A M Brölmann, Sebastiaan Veersema, Judith A F Huirne
AIM: To study changes in a ceasarean section (CS) scar during the first year after a CS using gel installation sonography (GIS). METHODS: Proof-of-concept study, prospective cohort study. Twenty women who delivered by their first CS were evaluated by both transvaginal sonography and GIS 2 months and 1 year after CS. A niche was defined as an anechogenic space at the uterine caesarean scar with a depth >2 mm. The primary outcome was any change in the thickness of the residual myometrium (RMT) as evaluated by GIS...
September 29, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28877521/case-report-pulmonary-tumor-thrombotic-microangiopathy-in-a-cervical-cancer-patient
#18
Naoya Tsujimoto, Ai Miyoshi, Mayuko Mimura, Toshio Naka, Masaru Yamasaki, Takeshi Yokoi
Pulmonary tumor thrombotic microangiopathy (PTTM) is a rapidly progressive and often fatal pulmonary disease induced by tumor emboli within the small pulmonary arteries. PTTM presents clinically as progressive hypoxia and pulmonary hypertension. Most cases of PTTM are caused by an adenocarcinoma of the stomach. We present the first case report of PTTM caused by cervical squamous cell carcinoma. An 82-year-old woman presented with vaginal bleeding and exertional dyspnea. A cervical mass biopsy showed squamous cell carcinoma...
September 7, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28873380/the-endometriosis-fertility-index-is-useful-for-predicting-the-ability-to-conceive-without-assisted-reproductive-technology-treatment-after-laparoscopic-surgery-regardless-of-endometriosis
#19
Rutsuko Hobo, Koji Nakagawa, Chie Usui, Rie Sugiyama, Nao Ino, Hiroshi Motoyama, Yasushi Kuribayashi, Masato Inoue, Rikikazu Sugiyama
OBJECTIVE: The endometriosis fertility index (EFI) is a novel index for predicting pregnancy after surgery. We investigated the utility of the EFI for predicting the ability to conceive without assisted reproductive technology (ART) treatment after laparoscopic surgery. METHODS: From July 2011 through December 2012, we recruited 133 infertile patients who underwent laparoscopy, and the EFI was calculated. After surgery, 55 of 133 achieved pregnancy without ART treatment...
September 6, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28850957/expression-of-mitochondrial-respiratory-chain-complexes-in-the-vaginal-wall-in-postmenopausal-women-with-pelvic-organ-prolapse
#20
Ivana Alujević Jakus, Dora Jakus, Jasna Marinović, Marija Ćavar, Ivana Banić, Katarina Vilović
BACKGROUND/AIMS: Pelvic organ prolapse (POP) is a common disease affecting adult women. It is a result of the vaginal wall disorder as well as damage of the supportive structures contributing to the integrity of the pelvic floor. Mitochondrial disorders may have an important role in the vaginal wall degeneration leading to POP. The goal of this research is to examine if POP is associated with an altered expression of mitochondrial respiratory chain complexes. METHODS: Samples of vaginal tissue were collected from 16 postmenopausal women: 10 had POP and 6 had other forms of benign gynecological disease...
August 30, 2017: Gynecologic and Obstetric Investigation
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