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Gynecologic and Obstetric Investigation

Jing Li, Jun Zhou, Yuanhua Ye, Qunying Liu, Xiaojin Wang, Ning Zhang, Xietong Wang
BACKGROUND: Previous studies have shown that oxidative stress is an important factor in preeclampsia (PE). Heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor-2 (Nrf2) are protective proteins that are involved in combating oxidative stress in the body. Nrf2 is also an essential upstream transcription factor regulating HO-1. This study was aimed at exploring the physiological roles of HO-1 and Nrf2 in PE. METHODS: Serum and placenta were collected from 30 patients who presented with severe PE and 30 healthy pregnant females...
October 21, 2016: Gynecologic and Obstetric Investigation
Sara Iacoponi, Ignacio Zapardiel
AIMS: Vulvar cancer is a rare disease. In western European countries, the incidence is 1.2 cases per 100,000 women/year. The aim of this study was to analyze the management and disease-free survival (DFS) of vulvar cancer among European countries. METHODS: An international multicenter retrospective study including patients diagnosed of squamous cell vulvar cancer was performed. Countries analyzed included Austria, Germany, Greece, Italy, Latvia, Lithuania, Poland, Portugal, Spain and Turkey...
October 14, 2016: Gynecologic and Obstetric Investigation
Tarek El-Toukhy, Omar El Tokhy
No abstract text is available yet for this article.
October 14, 2016: Gynecologic and Obstetric Investigation
Maria Francesca Perelló, Maria Ángeles Martínez-Zamora, Ximena Torres, Jordina Munrós, Juan Balasch Cortina, Francisco Carmona
BACKGROUND: The identification of presurgical clinical markers may be helpful to allow the staging of endometriosis severity. It has been suggested that pain characteristics orientate the gynecologist about the anatomical involvement of endometriosis. The study was performed to analyze the correlation between pain symptoms and the anatomical location of endometriosis. METHODS: One hundred fifty-five consecutive patients with a complete removal of deep infiltrating endometriosis (DIE) were included...
October 7, 2016: Gynecologic and Obstetric Investigation
Covadonga Alvarez-Lopez, Javier De Santiago, Antonio Piñera, Roberto Rodriguez, Beatriz Herrero, Maria Herrera, Jaime Pillado, Ignacio Zapardiel
BACKGROUND: To determine the utility of three-dimensional (3D) sonography to control the position of hysteroscopic sterilizing device compared to hysterosalpingography (HSG). METHODS: A prospective observational study was carried out on 139 patients who underwent hysteroscopic tubal occlusion method between February 2012 and May 2013. Patients underwent 3D ultrasound scan to control device positioning, and they also underwent HSG as an additional control method...
October 6, 2016: Gynecologic and Obstetric Investigation
Erik Arbeid, Alessio Demi, Etrusca Brogi, Elisa Gori, Teresa Giusto, Gino Soldati, Luigi Vetrugno, Francesco Giunta, Francesco Forfori
BACKGROUND/AIMS: The normal lung ultrasound (US) pattern during a regular pregnancy has not been evaluated extensively in the current literature. Pregnancy-related changes in the respiratory tract affect maternal predisposition to several respiratory complications; consequently, it is important to differentiate between a physiologic pattern during pregnancy and a pathologic lung pattern, due to respiratory failure. The goal of our study was to assess the normal US lung pattern in women without known comorbidities in the last weeks of pregnancy...
October 5, 2016: Gynecologic and Obstetric Investigation
Francesco Maneschi, Desiree Biccirè, Giusi Santangelo, Seila Perrone, Alberto Scaini, Carmine Cosentino
PURPOSE: This study is aimed at investigating the clinical efficacy of the 4-category classification of urgent cesarean section. METHODS: Women giving birth from September 2012 to December 2014 were prospectively investigated. Urgency C-section categories were color-coded: red - maternal/fetal life threat; yellow - maternal/fetal compromise, not life-threatening; and green - early delivery necessary. Results were audited. RESULTS: A total of 4,754 women gave birth in the period considered, 1,313 (27...
September 30, 2016: Gynecologic and Obstetric Investigation
Askin Dogan, Ziad Hilal, Harald Krentel, Cem Cetin, Lukas A Hefler, Christoph Grimm, Clemens B Tempfer
BACKGROUND: Extramammary Paget's disease of the vulva (EPDV) is a rare adenocarcinoma in situ of the vulvar skin and is often resected with involved margins due to its reticular growth pattern. Adjuvant treatment with the immunomodulator imiquimod may be suitable to avoid repeated and mutilating surgery. CASE PRESENTATION: We present the case of a 73-year-old woman with EPDV, initially treated with surgical resection and re-resection for involved margins. Final histology revealed Paget's disease of the left vulva with 8 cm in the largest diameter and again involved margins...
September 22, 2016: Gynecologic and Obstetric Investigation
Carmen A H Severens-Rijvers, Salwan Al-Nasiry, Chahinda Ghossein-Doha, Sara Marzano, Hugo Ten Cate, Bjorn Winkens, Marc A E Spaanderman, Louis L H Peeters
BACKGROUND/AIM: Placental syndromes (PS) are characterized by endothelial dysfunction complicating placental dysfunction. Possible markers for endothelial dysfunction and amount of trophoblast are fibronectin and plasminogen activator inhibitor-2 (PAI-2), respectively. We aimed (1) to determine whether in women with recurrent PS (rPS), this complication is preceded by deviating fibronectin- and PAI-2-levels, and (2) whether this is dependent on pre-pregnant plasma volume (PV). METHODS: In 36 former patients, we determined fibronectin- and PAI-2-levels in blood-samples collected preconceptionally and at 12-16 weeks in their next pregnancy...
September 20, 2016: Gynecologic and Obstetric Investigation
Ying Yao, Kun Zhang, Jinsong Han, Junfang Yang, Fuli Zhu, Yiting Wang, Jie Qiao
BACKGROUND AND AIM: This study is aimed at investigating the tissue reactions of heterogenic and allogeneic acellular dermal matrix (ADM) mesh implanted in the vesicovaginal space in a rabbit model. METHODS: Twenty eight rabbits were implanted with heterogenic or allogeneic mesh, respectively, in the vesicovaginal space, and 4 served as the no-implantation control group. Rabbits were sacrificed at 7, 30, and 90 days after implantation. Histopathological study and immunohistochemical examination for collagen were performed...
September 15, 2016: Gynecologic and Obstetric Investigation
Filip A Dabrowski, Anna Burdzinska, Agnieszka Kulesza, Marcin Chlebus, Beata Kaleta, Jan Borysowski, Aleksandra Zolocinska, Leszek Paczek, Miroslaw Wielgos
BACKGROUND/AIM: Mesenchymal stem cells (MSCs) are gaining rising interest in gynecology and obstetrics. MSCs immunomodulatory properties are suitable enough to reduce perinatal morbidity caused by inflammation in premature neonates. The aim of this study was to evaluate and compare the ability to inhibit allo-activated lymphocytes proliferation by MSCs derived from different sources: amniotic membrane (AM), umbilical cord (UC) and adipose tissue (AT). METHODS: MSCs were isolated from AM (n = 7) and UC (n = 6) and AT (n = 6) of healthy women...
September 15, 2016: Gynecologic and Obstetric Investigation
Mauro Cozzolino, Dimitrios Nasioudis, Giovanni Sisti, Maria Elisabetta Coccia
BACKGROUND: The study aimed to examine all available evidence regarding primary vaginal cancer arising from endometriosis from an evidence-based perspective. METHODS: A literature search in Medline and EMBASE databases was conducted. The following key words were employed: 'vaginal cancer' AND 'endometriosis malignant transformation' OR 'endometriosis'. RESULTS: A total of 23 eligible studies were identified and included in the present review providing information for 37 patients...
September 13, 2016: Gynecologic and Obstetric Investigation
Stamatios Petousis, Ioannis Kalogiannidis, Chrysoula Margioula-Siarkou, Apostolos Mamopoulos, George Mavromatidis, Nikolaos Prapas, David Rousso
OBJECTIVE: Τhe study aimed to study the rate of atypical squamous cells of undetermined significance (ASCUS) that progressed to high-grade squamous intraepithelial lesions (HGSIL), as well as the number of patients who finally necessitated a surgical intervention during follow-up. METHODS: A prospective study was conducted on patients admitted for colposcopy during 2007-2012. We exclusively included those who presented with newly ASCUS diagnosis, while patients with a history of cervical intraepithelial neoplasia (CIN) were excluded...
September 13, 2016: Gynecologic and Obstetric Investigation
Jacob Mørup Schlütter, Gry Johansen, Rikke Bek Helmig, Olav Bjørn Petersen
We report 2 cases of true uterine artery aneurysms diagnosed during pregnancy. Both cases presented with nonspecific symptoms such as urethral obstruction, minimal vaginal bleeding and lower abdominal pain in the 2nd trimester. Both aneurysms were diagnosed by color Doppler ultrasound. In the first case labor was induced at 37 + 4 weeks of gestation. However, due to sudden fetal distress and maternal abdominal pain, an emergency Caesarean section was performed during labor, and 3 liters of intra-peritoneal blood were encountered upon laparotomy, secondary to a ruptured uterine artery aneurysm...
September 13, 2016: Gynecologic and Obstetric Investigation
Florian Lenz, Sara Doll, Christof Sohn, Kerstin A Brocker
AIM: To evaluate the different pull-out-force out of the obturator membrane and the obturator internus muscle of 2 mini-sling systems for stress urinary incontinence (SUI) treatment. MATERIAL AND METHODS: In a prospective study, the pull-out-force measurements were performed on 8 female cadaver pelvises, both on the obturator membrane and internal muscle, using the force measurement device PCE-FM50 (PCE Instruments). Tested were the hooks of 2 on the market available mini-sling kits (MiniArc by American Medical System; Ajust by BARD Inc...
September 7, 2016: Gynecologic and Obstetric Investigation
Maria A Leal, Antonio Piñera, Javier De Santiago, Ignacio Zapardiel
In April 2014, the US Food and Drug Administration published a safety communication warning of the risk of an unsuspected uterine sarcoma being morcellated during a laparoscopic procedure and therefore advising against the use of power morcellation. These statements have encouraged the scientific community to look for new techniques that allows performing this procedure in a safer way, decreasing the risk of malignant dissemination thorough the abdominal cavity. We describe a new technique for power morcellation using a plastic bag through umbilicus using a latex glove and skin retractor as a single port device...
September 6, 2016: Gynecologic and Obstetric Investigation
Hakan Erenel, Nevin Yilmaz, Mahmut Oncul, Abdullah Serdar Acikgoz, Suat Karatas, Isil Ayhan, Berna Aslan, Abdullah Tuten
We aimed to investigate the clinical importance of serum procalcitonin (PCT) levels in the diagnosis of tubo-ovarian abscess (TOA). Patients diagnosed with pelvic inflammatory disease (PID; n = 36) and patients diagnosed with TOA (n = 42) were included in the study. Sociodemographic characteristics, laboratory and clinical parameters were compared between the 2 groups. Mean PCT level was higher in the TOA group (p = 0.004). Mean length of stay in hospital was longer in patients with TOA (p < 0.001). White blood cell count, neutrophil count, percentage of neutrophils and C-reactive protein levels were higher than normal limits in all patients; however, no differences in these parameters were observed between the groups...
September 3, 2016: Gynecologic and Obstetric Investigation
Kudret Erkenekli, Efser Oztas, Elif Kuscu, Uğur Keskin, Yasemin Gulcan Kurt, Ahmet Tas, Nafiye Yilmaz
BACKGROUND/AIMS: Dyslipidemia is common in women with polycystic ovary syndrome (PCOS) irrespective of age. Our aim was to investigate soluble tumor necrosis factor like weak inducer of apoptosis (sTWEAK), a cardiovascular risk marker in PCOS, and to determine if it is associated with dyslipidemia in youth. METHODS: A prospective-observational study was carried out including 35 PCOS patients and 35 healthy controls. Serum sTWEAK levels were measured using commercially available kits...
August 27, 2016: Gynecologic and Obstetric Investigation
Ming-Hui Liu, Wen-Hui Zhou, Da-Peng Chu, Lei Fu, Wei Sha, Yuan Li
AIM: The study aimed to assess the effect of in vitro vitrification and maturation on the nuclear configuration, cytoplasmic maturation and global DNA methylation pattern of human germinal vesicle (GV) stage oocytes. METHODS: Human oocytes from infertile women were randomly assigned to one of 3 groups: (i) metaphase II (MII) oocytes matured in vivo (vivo-MII, n = 56) as controls; (ii) MII oocytes matured in vitro (vitro-MII, n = 106); and (iii) MII oocytes that were vitrified at the GV stage, warmed and matured in vitro (cryo-MII, n = 122)...
August 24, 2016: Gynecologic and Obstetric Investigation
Qingqin Kong, Wenfeng Wang, Ling Luo, Xiangxiu Sun
BACKGROUND: We hypothesized that apurinic/apyrimidinic endonuclease 1 (APE1) may regulate cell activity via activator protein 1 (AP-1) signaling pathway through its redox function in the development of ovarian cancer. METHODS: Ovarian cancer and paired paracarcinoma tissues were collected for determining APE1 expression with immunohistochemistry. Cell transfection was performed to silence APE1. For mRNA and protein expressions of genes after silencing, real-time reverse transcription polymerase chain reaction and Western blot assay were conducted...
August 24, 2016: Gynecologic and Obstetric Investigation
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