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Gynecologic and Obstetric Investigation

Özgür Kan, Ali Gemici, Aysegul Alkilic, Elif Nazli Cetindag, Caner Cakir, Riza Dur, Metin Altay
BACKGROUND: Consecutive measurements of β-hCG levels and sonographic evaluation of adnexae are critical for choosing the optimal management in ampullar tubal ectopic pregnancies (EP). To select suitable patients for conservative approach, there is a need for an affordable and reliable marker for determining rupture risk. Evaluation of systemic inflammatory markers in combination with serum β-hCG levels and ultrasound might help to decide the appropriate treatment option. OBJECTIVE: The purpose of the present study was to evaluate the diagnostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in determining the rupture risk in ampullar tubal EPs and to compare with intraoperative findings...
January 17, 2019: Gynecologic and Obstetric Investigation
María Isabel Peña-Cano, Renata Saucedo, Enrique Morales-Avila, Jorge Valencia, Jose A Zavala-Moha, Adriana López
BACKGROUND: Obesity is a risk factor for breast cancer (BC). Some mechanisms through which obesity can lead to cancer development are insulin-like growth factors (IGFs), adipokines, and microRNAs (miRs). The objective of the study was to determine whether miR-17-5p, miR-195-5p, and miR-221-3p expressions were deregulated in serum samples of obese and nonobese postmenopausal women with BC. In addition, insulin, adiponectin, leptin and IGFs were analyzed. METHODS: Fifty postmenopausal women with newly diagnosed BC and 50 postmenopausal healthy women were evaluated...
January 16, 2019: Gynecologic and Obstetric Investigation
Lucie Hympanova, Rita Rynkevic, Iva Urbankova, Silvia Blacher, Laurent de Landsheere, Katerina Mackova, Ladislav Krofta, Jan Deprest
BACKGROUND/AIMS: The ewe is increasingly being used as an animal model for pelvic floor disorders. The aim was to further characterize changes in the vaginal properties during its entire lifespan. METHODS: Vaginal tissues were collected at different stages of reproductive life (neonatal, prepubescence, nulliparous, primiparous, multiparous, and menopausal; ≥6 ewes/group). Vaginal size, as well as active and passive biomechanics, was measured. Microscopy included thickness of glycogen, epithelium, lamina propria and muscularis thickness, densities of collagen, elastin, smooth muscle, and nerves...
January 11, 2019: Gynecologic and Obstetric Investigation
Zahra Bajalan, Zainab Alimoradi, Farnoosh Moafi
BACKGROUND: The incidence and severity of primary dysmenorrhea are influenced by various factors. The aim of the present study was to review nutritional factors influencing primary dysmenorrhea. METHODS: Academic databases including Web of Science, EMBASE, Scopus, and PubMed (including Medline) were searched using keywords of nutrition, diet, and primary dysmenorrhea. In this study, observational studies that were published in English from 1990 to April 2018, which focused on nutritional factors affecting primary dysmenorrhea, were selected...
January 10, 2019: Gynecologic and Obstetric Investigation
Shanshan Qin, Yingchun Gao, Yijun Yang, Lei Zhang, Ting Zhang, Juanpeng Yu, Can Shi
AIM: Recurrence being a major challenge for the treatment of cervical cancer, we aimed at identifying novel molecular markers of cervical cancer to improve recurrence prediction. METHODS: Cervical cancer samples were obtained from the Cancer Genome Atlas. Prognosis-associated long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs between recurrent and nonrecurrent samples were acquired using expression analysis. Regulatory relationships among these prognosis-associated RNAs were predicted and used to construct a competing endogenous RNA (ceRNA) network...
January 9, 2019: Gynecologic and Obstetric Investigation
Yan Wei, Jianru Luo, Dan Luo
BACKGROUND: We aimed to compare the hemostatic effect and perioperative outcomes between internal iliac artery (IIA) and abdominal aorta (AA) balloon occlusions in pernicious placenta previa patients complicated with placenta accrete and underwent cesarean delivery. METHODS: One hundred and twenty-three pernicious placenta previa patients complicated with placenta accrete were retrospectively reviewed. Patients who received IIA or AA occlusions were subsequently divided into the IIA group (n = 71) and AA group (n = 52)...
January 9, 2019: Gynecologic and Obstetric Investigation
Lei Chu, Hanbo Ma, Junhua Liang, Li Li, Aiqun Shen, Jianjun Wang, Huaifang Li, Xiaowen Tong
BACKGROUND/AIM: We aimed to assess the value of early laparoscopic therapy in management of tubo-ovarian abscess (TOA) or pelvic abscess. METHODS: This was a retrospective study of all consecutive patients who were initially diagnosed with TOA or pelvic abscess at the local hospital between January 2010 and December 2014. The risks of operation and recurrence were analyzed using logistic analyses. RESULTS: The durations of body temperature > 38...
January 4, 2019: Gynecologic and Obstetric Investigation
Sujinun Nunthapiwat, Ratanaporn Sekararithi, Chanane Wanapirak, Supatra Sirichotiyakul, Fuanglada Tongprasert, Kasemsri Srisupundit, Suchaya Luewan, Theera Tongsong
OBJECTIVE: To determine the association between second-trimester serum Down syndrome screening (alpha-fetoprotein [AFP] free beta-human chorionic gonadotropin [b-hCG] unconjugated estriol [uE3]) and preterm birth and to create predictive models for preterm birth. METHODS: Secondary analysis on a prospective database of pregnancies undergoing second-trimester screen with complete follow-up. The multiples of medians (MoM) of the biomarkers were compared between the group of term, preterm (< 37 weeks), early preterm (< 34 weeks), and very early preterm (< 32 weeks) delivery...
January 2, 2019: Gynecologic and Obstetric Investigation
Jacqueline Feinberg, Benjamin Albright, Jonathan Black, Lingeng Lu, Rachel Passarelli, Stefan Gysler, Margaret Whicker, Gary Altwerger, Gulden Menderes, Pei Hui, Alessandro D Santin, Masoud Azodi, Dan-Arin Silasi, Elena S Ratner, Babak Litkouhi, Peter E Schwartz
AIMS: To compare baseline risk factors for type 1 vs. 2 endometrial cancers and analyze these risk factors for association with overall survival and time to recurrence. METHODS: Retrospective review of 816 consecutive endometrial cancer cases was conducted with diagnosis from January 2005 to December 2010 and clinical course until 2016. Risk factors, treatment, recurrence, and death were compared using 2 sample t tests, χ2 test and Cox Regression models. RESULTS: There were 550 cases of type 1 and 266 cases of type 2 cancer...
January 2, 2019: Gynecologic and Obstetric Investigation
Haibin Zhao, Hui Liu, Mei Li, Shuiying Ma, Cheng Li, Keliang Wu
BACKGROUND/AIM: To compare the clinical outcomes between > 10- and 8-cell good quality embryos on day 3. METHODS: A retrospective study of a cohort of 459 patients was included in the fresh embryo transfer (ET) cycle group from January 2009 to April 2016. In this group, 2 good quality embryos on day 3, were transferred on corresponding dates, in 75 patients (> 10-cell embryos), and in 384 patients (8-cell embryos). Seven hundred and forty four patients, with 1 blastocyst transferred derived from > 10-cell (n = 183) or 8-cell (n = 561) good quality embryos on day 3, were assigned in the frozen ET (FET) group...
January 2, 2019: Gynecologic and Obstetric Investigation
Simone Ferrero, Valerio Gaetano Vellone, Fabio Barra, Carolina Scala
BACKGROUND/AIMS: Ulipristal acetate ([UPA], Esmya®) is an orally active selective progesterone-receptor modulator that has been approved as preoperative treatment for uterine myomas. This systematic review aims to summarize the available data on surgical outcomes of patients undergoing myomectomy by hysteroscopy or by laparoscopy after preoperative treatment with UPA. METHODS: this review was performed following PRISMA guidelines and was registered in PROSPERO (CRD42018092201)...
December 14, 2018: Gynecologic and Obstetric Investigation
Aharon Feldman, Sadaf Chaugle, Charlotte Burmeister, Adnan Munkarah, Mohamed A Elshaikh
OBJECTIVE: To compare survival endpoints between African American (AA) and non-AA (NAA) women with endometrial carcinoma (EC) stage I-II using a robust matching analysis. METHODS AND MATERIALS: Patients were matched by stage, grade, adjuvant management (surveillance, vaginal brachytherapy or pelvic radiation treatment), age, and year of hysterectomy. Recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) were calculated. RESULTS: A total of 758 patients were included...
December 12, 2018: Gynecologic and Obstetric Investigation
Fangui Zhao, Yang Xu, Hao Zhang, Yunyun Ren
AIMS: The aim of this study was to investigate the clinical features and ultrasonographic findings of uterine carcinosarcoma (UCS). METHODS: Seventy-five patients (mean age, 58.6 years) with pathologically proven UCS who were treated at our hospital from January 2003 to December 2015 were retrospectively recruited. The clinical features and preoperative findings on transvaginal sonography (TVS) were investigated. RESULTS: Eighty percent of the patients were postmenopausal...
November 30, 2018: Gynecologic and Obstetric Investigation
Rong Wang, Jinbin Li, Chunyu Yin, Di Zhao, Yulan Zhao, Yapeng Li, Ling Yin
BACKGROUND: This study aimed to investigate the action mechanism of β-estradiol in MCF-7 breast cancer (BC) cells. METHODS: The cell samples were sequenced using Hiseq 2000, including 2 MCF-7 controls and 2 samples treated with β-estradiol. Differentially expressed genes (DEGs) were screened using the NOISeq package in R, followed by the functions and pathways analyses using Database for Annotation, Visualization and Integrated Discovery. DEGs associated with β-estradiol were selected using the WbeGestalt software, and the corresponding target miRNAs of these genes were analyzed from different miRNA databases...
November 23, 2018: Gynecologic and Obstetric Investigation
Wenyan Wang, Jiaqi Liu, Jie Wang, Jidong Gao, Xiang Wang, Xin Wang
OBJECTIVES: This study aimed to evaluate the impact of locoregional resection and radiotherapy on the prognosis of Chinese women with stage IV breast cancer. METHODS: The retrospective study included Chinese patients with de novo stage IV breast cancer in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, between January 1, 2001, and December 31, 2016. The patients were classified into surgery and nonsurgery groups. Overall survival (OS) and distant progression-free survival (DPFS) were evaluated at the last follow-up...
November 16, 2018: Gynecologic and Obstetric Investigation
Davide De Vita, Giampiero Capobianco, Giovanni Gerosolima, Carmen Sciorio, Ermenegilda Coppola, Fabio Parazzini, Maurizio Silvestri, Anna Paola Caruso, Maddalena Morlando, Raffaele Petta, Alessandro Pascarella, Salvatore Dessole, Elsa Viora
BACKGROUND/AIMS: Abnormally invasive placenta (AIP) includes placenta accreta, increta, and percreta and represents major complications of pregnancy. This study was designed to assess the role of ultrasonography in the identification of AIP among pregnant women with antepartum diagnosis of placenta previa. METHODS: A cross-sectional study was performed between May 2015 and April 2016 in 11 centers, including 242 women with antepartum diagnosis of placenta previa...
November 16, 2018: Gynecologic and Obstetric Investigation
Jose Luis Sánchez-Iglesias, Assumpció Perez-Benavente, Alejandro Correa-Paris, Javier De la Torre Fernandez de Vega, Melchor Carbonell Socias, Antonio Gil-Moreno
AIMS: To evaluate overall survival (OS) and progression-free survival (PFS) in patients with stage IIIC epithelial ovarian, tubal and peritoneal cancer (EOC) who underwent a laparoscopy to assess surgical resectability prior to Primary Debulking Surgery (PDS) or Interval Debulking Surgery (IDS). METHODS: Retrospective cohort study that included all women with stage IIIC EOC treated at our center between 2000 and 2010. Patients were classified in groups: PDS, neoadjuvant chemotherapy (NACT) with IDS, NACT without IDS; and then sub-classified based on residual tumor (RT)...
November 14, 2018: Gynecologic and Obstetric Investigation
Shinichi Komiyama, Masaru Nagashima, Tomoko Taniguchi, Yuki Yokouchi, Tsuyoki Kugimiya
Ovarian endometriotic cysts have been identified as the possible origin of ovarian clear cell carcinoma (OCCC), so predicting or preventing future transformation is important. Early detection of clear cell carcinoma is important because it shows low sensitivity to chemotherapy and the prognosis is worse than for other histologic types. We recently treated 2 patients with OCCC. They were both young women with no family history of cancer who received long-term oral contraceptive therapy for endometriotic cysts, and the histologic diagnosis was typical clear cell carcinoma in both patients...
November 13, 2018: Gynecologic and Obstetric Investigation
Ali Alhousseini, Maheshwar Mahaseth, Salam Zeineddine, Sunil Jaiman, Susan Berman, David Bryant, Sidhartha Tan, Edgar Hernandez-Andrade
BACKGROUND: We discuss the ethical decision points in a case report that describes a novel COL1A1 mutation associated to Osteogenesis Imperfecta type II, but with a non-lethal outcome. CASE: A 33-year-old female underwent a 21-week ultrasound that revealed short bowed femurs and humeri with old fractures and bowed tibias and fibulas. Amniotic fluid testing revealed a novel COL1A1 mutation (c.1840G>A; p.Gly614Arg). OI Type II diagnosis was made. A previously reported mutation of the same gene but different locus (c...
November 8, 2018: Gynecologic and Obstetric Investigation
María Carolina Silva, Alvaro Sepúlveda-Martínez, Rodolfo Guíñez, María Teresa Haye, Mauro Parra-Cordero
BACKGROUNDS/AIMS: To assess the perinatal outcome of pregnancies with chorionic bump detected at the first trimester of pregnancy. METHODS: This was a nested case-control study of pregnancies with chorionic bump identified at the first trimester ultrasound that was performed from October 2014 and October 2016. The control group consisted of the following 5 unaffected pregnancies after each case. From the first trimester ultrasound, maternal and perinatal characteristics were obtained and stored in a dedicated database...
November 2, 2018: Gynecologic and Obstetric Investigation
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