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Gynecologic and Obstetric Investigation

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https://www.readbyqxmd.com/read/28329740/human-chorionic-gonadotropin-regression-curves-after-partial-or-complete-molar-pregnancy-in-flanders-are-they-different-from-regression-curves-from-the-eighties
#1
Sien Delattre, Sileny Han, Philippe Moerman, Jaak Billen, Frédéric Goffin, Kathleen Scharpé, Ignace Vergote
BACKGROUND/AIMS: We updated human chorionic gonadotropin (hCG) regression curves created in the eighties after evacuation of complete and partial molar (CM and PM, respectively) pregnancies using modern hCG assays. We created similar curves for patients in need of chemotherapy (gestational trophoblastic neoplasia [GTN]). METHODS: A total of 126 patients who were diagnosed with gestational trophoblastic disease from 1990 to 2014 were included. We compared curves from 2 groups, CM and PM, with historical ones...
March 23, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28222446/the-timing-of-embryo-transfer-catheter-removal-should-it-be-delayed-or-done-immediately-a-prospective-randomized-trial
#2
Belgin Devranoğlu, Özkan Özdamar, Yiğit Çakıroğlu, Mehmet Küçükbaş, Meryem K Eken, Emek Doğer
BACKGROUND/AIMS: Data on the timing of catheter removal technique following embryo transfer (ET) are quite limited. We aimed to compare the reproductive outcomes of intracytoplasmic sperm injection (ICSI)/ET cycles in which the transfer catheter was removed immediately with those in which the catheter was removed after a delay period and hereby to evaluate the impact that the time interval before removal of the catheter following embryo deposit may have on the fertility outcomes. METHODS: A prospective randomized study was designed...
February 22, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28222431/the-routine-use-of-intrapartum-ultrasound-in-clinical-decision-making-during-the-second-stage-of-labor-does-it-have-any-impact-on-delivery-outcomes
#3
Oren Barak, Roni Levy, Orna Flidel, Svetlana Zaks, Moshe Gillor, Zion Hagay, Edi Vaisbuch
BACKGROUND/AIMS: The study aimed to assess whether the use of intrapartum transperineal ultrasound (US) can reduce the rate of failed vacuum extraction (VE). METHODS: This is a retrospective cohort study including all women delivering at term with the diagnosis of protracted second stage of labor. The mode of delivery and rate of failed VE were compared between women who underwent a US examination prior to the decision on obstetrical interventions ("+US" group) and those in whom clinical decisions were based upon digital assessment only ("no-US" group)...
February 22, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28222428/neonatal-and-maternal-short-term-outcome-parameters-in-instrument-assisted-vaginal-delivery-compared-to-second-stage-cesarean-section-in-labour-a-retrospective-11-year-analysis
#4
Moritz Polkowski, Elna Kuehnle, Cordula Schippert, Sudip Kundu, Peter Hillemanns, Ismini Staboulidou
BACKGROUND: This study is aimed at comparing the neonatal and maternal short-term outcomes after instrumental-assisted vaginal delivery and cesarean section (CS) in labour. METHODS: This retrospective study over a period of 11 years included singleton pregnancies above 34 + 0 gestational weeks, giving birth either by instrumental-assisted delivery or CS in labour. Maternal and neonatal outcome parameters were analysed using t test or linear regression. RESULTS: A total of 1,971/2,571 deliveries were included for analysis: 149 forceps-, 393 vacuum-assisted deliveries and 1,420 CS in labour...
February 22, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28222427/impact-of-fmr1-pre-mutation-status-on-blastocyst-development-in-patients-undergoing-pre-implantation-genetic-diagnosis
#5
Anne P Hutchinson, Nigel Pereira, Debra P Lilienthal, Siobhán Coveney, Jovana P Lekovich, Rony T Elias, Zev Rosenwaks
BACKGROUND/AIMS: The study aimed to investigate the impact of fragile X mental retardation 1 (FMR1) pre-mutation status on blastocyst development in patients undergoing pre-implantation genetic diagnosis (PGD). METHODS: Case-control study of patients <40 years undergoing PGD at blastocyst stage for FMR1 pre-mutation status. Age-matched patients undergoing PGD for other single gene disorders were considered controls. Blastocyst development, calculated per metaphase II (MII) oocyte retrieved and per 2 pronuclear (2PN) embryos, was compared between the 2 groups...
February 22, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28183074/a-comprehensive-comparison-of-ct-mri-positron-emission-tomography-or-positron-emission-tomography-ct-and-diffusion-weighted-imaging-mri-for-detecting-the-lymph-nodes-metastases-in-patients-with-cervical-cancer-a-meta-analysis-based-on-67-studies
#6
Bin Liu, Sujuan Gao, Shuofeng Li
OBJECT: In recent times, many published papers reported the diagnostic performance of CT, MRI, positron emission tomography (PET) using 2-[18F] fluoro-2-deoxy-D-glucose (FDG) and diffusion-weighted magnetic resonance imaging (DW-MRI) for detecting the lymph nodes (LNs) metastases in patients with cervical cancer. This study is aimed at assessing and comparing the diagnostic value of those non-invasive modalities in detecting the LNs metastases in cervical cancer patients. METHODS: Studies on the non-invasive modalities for the detection of metastatic LNs were searched in PubMed, Medline, Web of Science, Cochrane Library and Embase databases...
February 10, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28147379/decidualization-mediated-by-steroid-hormones-modulates-the-innate-immunity-in-response-to-group-b-streptococcal-infection-in-vitro
#7
Violeta Castro-Leyva, Veronica Zaga-Clavellina, Aurora Espejel-Nuñez, Rodrigo Vega-Sanchez, Arturo Flores-Pliego, Enrique Reyes-Muñoz, Silvia Giono-Cerezo, Sonia Nava-Salazar, Salvador Espino Y Sosa, Guadalupe Estrada-Gutierrez
BACKGROUND: Decidual cells play a role in the modulation of the innate immune response to protect pregnancy against infection. Steroid hormones regulate the innate immune response in different tissues, and they are involved in several biological processes like decidualization. The aim of this study was to assess if steroid hormones modulate the innate immunity in endometrial stromal cells (ESCs) and decidual stromal cells (DSCs) in response to group B streptococcus (GBS) infection in vitro...
February 2, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28125816/comparative-anatomy-of-the-ovine-and-female-pelvis
#8
Iva Urbankova, Katarina Vdoviakova, Rita Rynkevic, Nikhil Sindhwani, Dries Deprest, Andrew Feola, Paul Herijgers, Ladislav Krofta, Jan Deprest
BACKGROUND: Pelvic organ prolapse affects half of vaginally parous women. Several animal models are used to study its pathophysiology and treatment. Sheep are interesting because they develop spontaneously prolapse with similar risk factors as women and can be used for vaginal surgery. This study describes ovine pelvis anatomy and compares it to women's pelvis to provide anatomical tools for translational researchers. METHODS: MRI, pelvic dissections, and histology were used for detailed macro- and microscopic analysis of relevant anatomical structures in 6 nulliparous ewes...
January 27, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28125812/investigation-of-new-therapeutic-targets-in-undifferentiated-endometrial-sarcoma
#9
Min-Hyun Baek, Jeong-Yeol Park, Chae Chun Rhim, Jong-Hyeok Kim, Yangsoon Park, Kyu-Rae Kim, Joo-Hyun Nam
BACKGROUND: Undifferentiated endometrial sarcoma (UES) is a very rare subtype of uterine sarcoma, which has no consensus on the treatment. We investigated the expression of potential new therapeutic targets in UES to improve its aggressive clinical course and poor survival outcome. METHODS: The immunohistochemical expressions of vascular endothelial growth factor (VEGF), c-KIT, c-ABL, platelet derived growth factor receptor (PDGFR), protein kinase B (AKT1), mammalian target of rapamycin, epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER2), Wilms tumor (WT1), aromatase inhibitor (CYP19A1), and histone deacetylase (HDAC) series in 10 UES patients were assessed using tissue microarrays...
January 27, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28103590/risk-factors-for-intrapartum-fever-in-term-gestations-and-associated-maternal-and-neonatal-sequelae
#10
Angela P H Burgess, Justin E Katz, Michael Moretti, Nisha Lakhi
AIM: To determine factors associated with intrapartum fever and to examine associated maternal and neonatal outcomes. METHODS: Retrospective study of patients between 360/7 and 420/7 gestational weeks who entered spontaneous or induced active labor and developed temperature ≥38°C; a similar group that did not develop fever were controls. Univariate and multivariate analyses were performed with p < 0.05 as significant. RESULTS: Fifty-four febrile patients and 306 nonfebrile controls met inclusion criteria...
January 20, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28103589/the-effects-of-body-mass-index-on-second-trimester-amniotic-fluid-cytokine-and-matrix-metalloproteinase-levels
#11
Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Nese Basak, Ebru Celik
AIM: The aim of this study was to determine the effects of obesity on amniotic fluid (AF) inflammatory markers in second-trimester AF, testing the hypothesis that there is a relationship between maternal body mass index (BMI) and fetal inflammatory exposure. METHODS: AF was obtained from 84 singleton pregnant women undergoing elective amniocentesis for karyotype analysis at 16-24 weeks of gestation between April 2014 and May 2016. The cell-free AF was used to analyze interleukin (IL)-1β and IL-6, and matrix metalloproteinase (MMP)-1, MMP-6, and MMP-13...
January 20, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28052283/the-feasibility-of-conservative-management-for-morbidly-adherent-placenta-accidentally-encountered-after-vaginal-delivery
#12
Ran Cui, Junli Lu, Zhenyu Zhang, Huimin Bai
OBJECTIVE: To evaluate the feasibility of conservative management for patients with morbidly adherent placenta (MAP) accidentally encountered after term vaginal delivery. METHODS: Medical records of patients with MAP who were accidentally encountered after term vaginal delivery and treated in our hospital from January 2009 to December 2015 were retrospectively reviewed. RESULTS: A total of 8 eligible patients were included in this analysis...
January 5, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28052267/the-effect-of-instant-urinary-catheterization-on-pregnancy-outcomes-after-intracytoplasmic-sperm-injection-and-embryo-transfer
#13
Safak Olgan, Enver Kerem Dirican
AIM: To evaluate the effect of instant urinary catheterization on pregnancy rates in women who are on bed rest after embryo transfer (ET). METHODS: This retrospective study included patients who underwent intracytoplasmic sperm injection (ICSI) treatment at the Akdeniz University Fertility Clinic between January 2015 and March 2016. All patients were advised bed rest for an hour after ET. The clinic's electronic database was screened to identify the uterine anatomy of the patients, transferred embryo quality, and urinary catheterization status...
January 5, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28049197/venous-air-embolism-during-hysteroscopic-myomectomy-an-analysis-of-7-cases
#14
Cédric Van Dijck, Steffen Rex, Jasper Verguts, Dirk Timmerman, Marc Van de Velde, An Teunkens
Venous air embolism (VAE) is a rare but potentially fatal complication of hysteroscopic myomectomy. The symptoms of VAE range from mild and clinically insignificant to complete cardiovascular collapse during surgery. Anesthesiologists and surgeons should be aware of the clinical characteristics and predisposing factors of this possible adverse event. This report analyzes 7 cases of VAE, which occurred at the University Hospitals Leuven, in patients undergoing hysteroscopic myomectomy from April 2009 to April 2011...
January 4, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28030858/reviewing-patients-following-mesh-repair-the-benefits
#15
Claudia R Kowalik, M M E Lakeman, Josephine E Oryszczyn, Jan Paul W R Roovers
BACKGROUND/AIMS: The use of synthetic mesh implants for vaginal prolapse surgery is still a subject of debate due to safety concerns. We aimed to explore long-term complications of all women treated with mesh surgery for pelvic organ prolapse (POP) in our centre. METHODS: This is a cross-sectional study of 188 women who underwent vaginal mesh surgery in a Dutch University Hospital between 2007 and 2012. The prevalence of mesh exposure, pain symptoms and patient satisfaction has been documented...
December 29, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27832646/the-impact-of-a-standardized-oral-multinutrient-supplementation-on-embryo-quality-in-in-vitro-fertilization-intracytoplasmic-sperm-injection-a-prospective-randomized-trial
#16
Kazem Nouri, Katharina Walch, Andrea Weghofer, Martin Imhof, Christian Egarter, Johannes Ott
The role of micronutrients in fertility has recently gained increased attention. We aimed to test the impact of a standardized, multinutrient supplementation on outcomes after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a pilot study. One hundred women undergoing IVF/ICSI were prospectively included and randomized to receive either a multinutrient supplementation named PROfertil® female that included folic acid, selenium, vitamin E, catechins, glycyrrhizin, diosgenin, damiana and omega-3-fatty acids (study group; n = 50), or 400 µg folic acid (control group; n = 50)...
2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27811474/abdominal-wall-endometriosis-myofibroblasts-as-a-possible-evidence-of-metaplasia-a-case-report
#17
Mohamed Gamal Ibrahim, Eleonore Delarue, Elene Abesadze, Matthias Haas, Jalid Sehouli, Vito Chiantera, Sylvia Mechsner
In this study, we report about a patient with extra-uterine endometriosis (EM) in the abdominal wall muscle with evident metaplasia based on the abundant alpha smooth muscle actin (ASMA)-expressing myofibroblasts. Laparotomy excision of the abdominal wall EM was done following ultrasonographic evidence of a hypodense swelling in the right rectus abdominis, which was confirmed by MRI. Immunohistochemistry staining for ASMA and collagen I was done, with the results confirming that endometriotic stromal cells expressed both...
2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27705973/utility-of-three-dimensional-ultrasonography-to-assess-the-position-of-essure-tubal-occlusion-device-and-its-complications
#18
Covadonga Alvarez-Lopez, Javier De Santiago, Antonio Piñera, Roberto Rodriguez, Beatriz Herrero, Maria Herrera, Jaime Pillado, Ignacio Zapardiel
BACKGROUND: To determine the utility of three-dimensional (3D) sonography to control the position of hysteroscopic sterilizing device compared to hysterosalpingography (HSG). METHODS: A prospective observational study was carried out on 139 patients who underwent hysteroscopic tubal occlusion method between February 2012 and May 2013. Patients underwent 3D ultrasound scan to control device positioning, and they also underwent HSG as an additional control method...
2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27655036/paget-s-disease-of-the-vulva-treated-with-imiquimod-case-report-and-systematic-review-of-the-literature
#19
Askin Dogan, Ziad Hilal, Harald Krentel, Cem Cetin, Lukas A Hefler, Christoph Grimm, Clemens B Tempfer
BACKGROUND: Extramammary Paget's disease of the vulva (EPDV) is a rare adenocarcinoma in situ of the vulvar skin and is often resected with involved margins due to its reticular growth pattern. Adjuvant treatment with the immunomodulator imiquimod may be suitable to avoid repeated and mutilating surgery. CASE PRESENTATION: We present the case of a 73-year-old woman with EPDV, initially treated with surgical resection and re-resection for involved margins. Final histology revealed Paget's disease of the left vulva with 8 cm in the largest diameter and again involved margins...
2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27618565/malignant-transformation-of-vaginal-endometriosis-a-review-of-literature
#20
Mauro Cozzolino, Dimitrios Nasioudis, Giovanni Sisti, Maria Elisabetta Coccia
BACKGROUND: The study aimed to examine all available evidence regarding primary vaginal cancer arising from endometriosis from an evidence-based perspective. METHODS: A literature search in Medline and EMBASE databases was conducted. The following key words were employed: 'vaginal cancer' AND 'endometriosis malignant transformation' OR 'endometriosis'. RESULTS: A total of 23 eligible studies were identified and included in the present review providing information for 37 patients...
2017: Gynecologic and Obstetric Investigation
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