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Gynecologic and Obstetric Investigation

Ali Alhousseini, Maheshwar Mahaseth, Salam Zeineddine, Sunil Jaiman, Susan Berman, David Bryant, Sidhartha Tan, Edgar Hernandez-Andrade
BACKGROUND: We discuss the ethical decision points in a case report that describes a novel COL1A1 mutation associated to Osteogenesis Imperfecta type II, but with a non-lethal outcome. CASE: A 33-year-old female underwent a 21-week ultrasound that revealed short bowed femurs and humeri with old fractures and bowed tibias and fibulas. Amniotic fluid testing revealed a novel COL1A1 mutation (c.1840G>A; p.Gly614Arg). OI Type II diagnosis was made. A previously reported mutation of the same gene but different locus (c...
November 8, 2018: Gynecologic and Obstetric Investigation
María Carolina Silva, Alvaro Sepúlveda-Martínez, Rodolfo Guíñez, María Teresa Haye, Mauro Parra-Cordero
BACKGROUNDS/AIMS: To assess the perinatal outcome of pregnancies with chorionic bump detected at the first trimester of pregnancy. METHODS: This was a nested case-control study of pregnancies with chorionic bump identified at the first trimester ultrasound that was performed from October 2014 and October 2016. The control group consisted of the following 5 unaffected pregnancies after each case. From the first trimester ultrasound, maternal and perinatal characteristics were obtained and stored in a dedicated database...
November 2, 2018: Gynecologic and Obstetric Investigation
Federica Facchin, Laura Buggio, Federica Ottolini, Giussy Barbara, Emanuela Saita, Paolo Vercellini
AIMS: The economic burden of endometriosis and pelvic pain involves direct and indirect healthcare costs due to work loss and decreased productivity. However, the relation between endometriosis, pelvic pain, and employment remains underinvestigated. This study aimed at providing preliminary insights into this topic. METHODS: We compared the employment status (having vs. not having a job) in 298 consecutive endometriosis patients and in 332 women without a history of endometriosis (control group)...
October 31, 2018: Gynecologic and Obstetric Investigation
Vincent Balaya, Fabien Guimiot, Jean-François Uhl, Charlotte Ngo, Myriam Delomenie, Hélène Bonsang-Kitzis, Marie Gosset, Myriam Mimouni, Anne-Sophie Bats, Vincent Delmas, Richard Douard, Fabrice Lécuru
BACKGROUND/AIMS: This study aims to describe the autonomic nervous network of the female pelvis with a 3D model and to provide a safe plane of dissection during radical hysterectomy for cervical cancer. METHODS: Pelvises of 3 human female fetuses were studied by using the computer-assisted anatomic dissection. RESULTS: The superior hypogastric plexus (SHP) was located at the level of the aortic bifurcation in front of the sacral promontory and divided inferiorly and laterally into 2 hypogastric nerves (HN)...
October 31, 2018: Gynecologic and Obstetric Investigation
Sung-Hoon Kim, Meiling Liu, Hyun Seok Jin, Sunmin Park
BACKGROUND: We explored the genetic variants that were associated with polycystic ovary syndrome (PCOS) by genome-wide association study (GWAS) and evaluated the association of genetic risk scores (GRS) of the selected genetic variants with insulin resistance and the interaction of the GRS with nutrient intake to develop insulin resistance. METHODS: The 6 genetic variants involved in brain and nervous system (acid sensing ion channel subunit 2 rs8071961, rs1988598, and rs16589, macro domain containing 2 rs7262810 CHRM3 rs1867265 and chromosome 2 open reading frame 83 rs11889798) were selected from a GWAS of the PCOS study...
October 19, 2018: Gynecologic and Obstetric Investigation
Yongqing Zhang, Ying Yu, Luping Chen, Wei Zhao, Ketan Chu, Xiujun Han
AIMS: To investigate the risk factors of intra-amniotic infection (IAI) related to induction with single-balloon catheter (SBC). METHODS: A retrospective, case-control study including 58 cases of IAI patients who underwent induction with SBC was conducted in Women's Hospital, School of Medicine, Zhejiang University. For each case, 8 women who delivered during the same month and had no infection after SBC induction were selected for control. RESULTS: Compared with the control group, the IAI group had a higher rate of nulliparity (87...
October 17, 2018: Gynecologic and Obstetric Investigation
Mary Catherine Tolcher, Alexis N Hokenstad, Amy L Weaver, Michaela E McGree, Carl H Rose, Abimbola O Famuyide, Brian C Brost
BACKGROUND/AIMS: The aim of this study was to evaluate the impact of a restrictive labor induction approval process on induction and primary cesarean delivery rates. METHODS: A retrospective cohort study was conducted at a tertiary care academic center from 2006 through 2012. The cohort of deliveries before (pre-intervention) and after (post-intervention) the process included term, singleton pregnancies with no contraindication to vaginal delivery. The primary outcome was induction of labor rates, subgrouped on the basis of whether it was medically or nonmedically indicated...
October 12, 2018: Gynecologic and Obstetric Investigation
Jun Zhang, Xi Chen, Lei Bian, Yujing Wang, Hong Liu
BACKGROUND: Radiation therapy is a mainstay in the treatment of cervical cancer. However, most advanced and metastatic cervical cancers are resistant to radiation therapy because of the presence of cancer stem cells (CSCs). To date, no specific markers were found for cervical CSCs. METHODS: The fraction of CD44+/CD24+ cell subpopulation was detected with flow cytometry (FCM). The clonogenicity and radiosensitivity were detected using colony-formation and radiosensitivity assay...
October 12, 2018: Gynecologic and Obstetric Investigation
Fabio Barra, Antonio Simone Laganà, Fabio Ghezzi, Jvan Casarin, Simone Ferrero
BACKGROUND/AIMS: Epithelial ovarian cancer (EOC) is the sixth most commonly diagnosed cancer among women. Results with available therapies are far from being satisfactory and, therefore, current research is focusing on new anticancer drugs to improve the clinical response of these patients. Nintedanib is an oral multiple tyrosine kinases inhibitor, which targets angiogenesis. Considering the current scenario, the aim of this systematic review is to highlight the prevailing knowledge about pharmacokinetics, pharmacodynamics, clinical efficacy, and safety of Nintedanib for the treatment of advanced EOC...
October 10, 2018: Gynecologic and Obstetric Investigation
Alessandro Favilli, Elena Laurenti, Gian Maria Stagni, Luigi Tassi, Giampietro Ricci, Sandro Gerli
AIMS: To investigate sodium hyaluronate (SH) efficacy in the treatment of pregnancy rhinitis. METHODS: A single-center, prospective, open-label, 2 parallel-group study was carried out. Pregnant women affected by pregnancy rhinitis were randomly assigned to 1 of 2 groups: Group A was treated with SH, while Group B did not receive any treatment. Pregnancy rhinitis symptoms and quality of life (QOL) during pregnancy were investigated by administering a questionnaire and carrying out an otorhinolaryngoiatric visit...
October 3, 2018: Gynecologic and Obstetric Investigation
Julie Hakim, P Alex Smith, Manmohan Singh, Zhaolong Han, Raksha Raghunathan, Omar Wyman, Danielle Guffey, Kirill V Larin, William Cohn, Jennifer E Dietrich
BACKGROUND: Determining biomechanical changes in vaginal tissue with tissue stretch is critical for understanding the role of mechanotransduction on vaginal tissue healing. Noncontact dynamic optical coherence elastography (OCE) can quantify biomechanical changes in vaginal tissues noninvasively. Improved vaginal tissue healing will reduce postoperative complications from vaginal surgery. AIMS: (1) To complete dimensional assessments (DAs) of the vaginal tract. (2) To elucidate biomechanical properties (BMP) of porcine vaginal tissues (PVT)...
September 28, 2018: Gynecologic and Obstetric Investigation
Maya Frank Wolf, Reut Elon, Dunia Hassan, Doron Zarfati, Benjamin Diker, Oleg Shnaider, Jacob Bornstein
BACKGROUND: The etiology of vaginal bleeding during pregnancy may be obstetric or non-obstetric. Though colposcopy is generally not part of the routine evaluation of 2nd- or 3rd-trimester vaginal bleeding without obvious obstetrical cause, our department does perform colposcopy and cervical cytology testing in these patients. This study assessed the need and possible contribution of colposcopy in diagnosing the etiology of 2nd- and 3rd-trimester bleeding. METHODS: Retrospective analysis of colposcopy findings from 2012-2015 in patients with 2nd- or 3rd-trimester bleeding where an obstetrical cause was not found...
September 28, 2018: Gynecologic and Obstetric Investigation
Lu Gan, Yan Chen, Hua Liu, Wen-Hui Ju
AIM: To investigate whether long non-coding RNA (lncRNA) ZEB1 antisense 1 (ZEB1-AS1) affects cell migration and invasion of cervical cancer by regulating epithelial-mesenchymal transition (EMT) via the p38MAPK pathway. METHODS: Human cervical cancer cell line Hela was classified into Control, NC siRNA, ZEB1-AS1 siRNA, SB203580 (p38MAPK pathway inhibitor) and ZEB1-AS1 siRNA + Anisomycin (p38MAPK pathway activator) groups. Quantitative real-time polymerase chain reaction was performed for ZEB1-AS1 expression, Western blotting to measure p38MAPK signaling pathway-/EMT-related proteins, and Wound-healing and Transwell assays to evaluate cell migration and invasion respectively...
September 25, 2018: Gynecologic and Obstetric Investigation
Nina Rogenhofer, Daniela Mischitz, Corinna Mann, Johanna Gluderer, Viktoria von Schönfeldt, Udo Jeschke, Christian J Thaler
BACKGROUND: The important role of vitamin D3 in human health is well recognized. In this study, we measured serum concentrations of vitamin D3, vitamin B12 and B9 (folic acid) in 410 women undergoing in vitro fertilisation (IVF)/intracytoplasmatic sperm injection (ICSI) with dedicated focus on 3-month changes in consideration of patients' BMI. METHODS: Patients were of European origin and did not take any supplementation of D3. In preparing for pregnancy, patients took ≥4 weeks 400 µg folic acid combined with 9 µg vitamin B12 and 150 µg iodide as recommended...
September 25, 2018: Gynecologic and Obstetric Investigation
Jeong Sook Kim, Chung Won Lee, Jisun Yun, Jae Hoon Lee, Bo Hyun Yun, Joo Hyun Park, Seok Kyo Seo, SiHyun Cho, Young Sik Choi, Byung Seok Lee
AIMS: Our objective was to predict natural pregnancy after endometriosis surgery using the endometriosis fertility index (EFI). METHODS: A retrospective medical records review was conducted, examining patients surgically treated for endometriosis at a single center in Korea between January 2009 and February 2015. In total, 68 women attempting natural conception were analyzed by assessing age, preoperative serum CA-125, body mass index, revised American Fertility Society (rAFS) stage, EFI, and pregnancy outcome...
September 20, 2018: Gynecologic and Obstetric Investigation
Cevdet Adigüzel, Yılmaz Baş, Mehmet Deniz Erhan, Maimuna Abdi Gelle
BACKGROUND: Female genital mutilation/cutting (FGM/C) is a common sociocultural practice in many communities in Africa. Unfortunately, what females are forced to accept because they are helpless, in order to be an individual in social life and in the country they live in, is an important health issue that is not only harmful to the human body but also against human rights. OBJECTIVES: This study aimed to investigate the wishes, knowledge and attitude of Somali women regarding FMG/C...
September 18, 2018: Gynecologic and Obstetric Investigation
Cynthia V Maxwell, Hanan Al-Sehli, Jacqueline Parrish, Rohan D'Souza
Gestational breast cancer (GBC) is the second most commonly occurring malignancy affecting pregnant women. Management is complex due to potential foetal risks in the setting of maternal treatment. We report on the maternal, foetal, short-term neonatal and placental histopathologic findings of a retrospective cohort of pregnant women with either pre-gestational (group 1) or GBC (group 2) from a tertiary-level maternity care centre. Of the 69 women identified over 12 years, there were 47 in group 1 and 22 in group 2...
September 14, 2018: Gynecologic and Obstetric Investigation
Ngozi N Joe-Ikechebelu, George Uchenna Eleje, Emmanuel Onyebuchi Ugwu, Chidimma Donatus Okafor, Cyril Emeka Nwachukwu, Princeston C Okam, Obinna E Ogboji, Joseph Ifeanyichukwu Ikechebelu
BACKGROUND/AIMS: To compare the efficacy and safety of trocar-site infiltration with lidocaine and no intervention for postoperative pain relief after diagnostic laparoscopy. METHODS: A randomized clinical trial of women with infertility scheduled for diagnostic laparoscopy without additional procedures in Life Institute for Endoscopy at Life Specialist Hospital, Nnewi, Nigeria. One hundred and ninety nine women were assigned at random to either trocar-site infiltration with lidocaine (n = 100) or no intervention (n = 99)...
August 24, 2018: Gynecologic and Obstetric Investigation
Konstantinos Sfakianoudis, Mara Simopoulou, Nikolaos Nitsos, Anna Rapani, Agni Pantou, Terpsithea Vaxevanoglou, Georgia Kokkali, Michael Koutsilieris, Konstantinos Pantos
Poor responders are described as those In Vitro Fertilization (IVF) patients who are failing to respond to controlled ovarian stimulation protocols. Extensive research has focused on crafting the optimal treatment. However, it appears that each approach fails to be established as effective or guaranteed towards successful management. Platelet-Rich Plasma (PRP) is a novel, highly promising approach that has been successfully applied for an array of medical issues. In this case series, we present 3 poor responder patients with the common denominator of: failed IVF attempts, poor oocyte yield, and poor embryo quality...
August 22, 2018: Gynecologic and Obstetric Investigation
Mehmet Ozgur Akkurt, Iltac Akkurt, And Yavuz, Serenat Eris Yalcin, Bora Coskun, Mekin Sezik
AIM: To evaluate the effect of intracardiac potassium chloride feticide procedure (FP) on the induction-to-abortion (I-to-A) interval for various indications in the termination of pregnancy. METHOD: Medically indicated abortions between 17 and 28 weeks' gestation were retrospectively evaluated and allocated into 2 groups: Cases with (group 1, n = 58) or without an FP (group 2, n = 60). I-to-A intervals were compared across the groups, considering different baseline parameters and fetal abnormality categories...
August 10, 2018: Gynecologic and Obstetric Investigation
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