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Gynecologic and Obstetric Investigation

Jeong Sook Kim, Chung Won Lee, Jisun Yun, Jae Hoon Lee, Bo Hyun Yun, Joo Hyun Park, Seok Kyo Seo, SiHyun Cho, Young Sik Choi, Byung Seok Lee
AIMS: Our objective was to predict natural pregnancy after endometriosis surgery using the endometriosis fertility index (EFI). METHODS: A retrospective medical records review was conducted, examining patients surgically treated for endometriosis at a single center in Korea between January 2009 and February 2015. In total, 68 women attempting natural conception were analyzed by assessing age, preoperative serum CA-125, body mass index, revised American Fertility Society (rAFS) stage, EFI, and pregnancy outcome...
September 20, 2018: Gynecologic and Obstetric Investigation
Cevdet Adigüzel, Yılmaz Baş, Mehmet Deniz Erhan, Maimuna Abdi Gelle
BACKGROUND: Female genital mutilation/cutting (FGM/C) is a common sociocultural practice in many communities in Africa. Unfortunately, what females are forced to accept because they are helpless, in order to be an individual in social life and in the country they live in, is an important health issue that is not only harmful to the human body but also against human rights. OBJECTIVES: This study aimed to investigate the wishes, knowledge and attitude of Somali women regarding FMG/C...
September 18, 2018: Gynecologic and Obstetric Investigation
Frédéric Amant, Linda Nooij, Daniela Annibali, Anne-Sophie van Rompuy, Sileny Han, Heidi van den Bulck, Frédéric Goffin
In this brief report, we present our experience with 3-weekly paclitaxel-carboplatin chemotherapy for patients with vulvar cancer. Two patients with locally advanced disease had an impressive response allowing standard vulvar cancer surgery. One patient with metastatic disease had local stable disease though it was progressive in the lymph nodes. The available literature is sparse and retrospective. Based on promising results, however, a prospective multicenter study is mandatory in order to obtain full data in a larger series of patients in order to learn the benefits of neoadjuvant paclitaxel-carboplatin and compare the results with chemoradiation...
September 18, 2018: Gynecologic and Obstetric Investigation
Cynthia V Maxwell, Hanan Al-Sehli, Jacqueline Parrish, Rohan D'Souza
Gestational breast cancer (GBC) is the second most commonly occurring malignancy affecting pregnant women. Management is complex due to potential foetal risks in the setting of maternal treatment. We report on the maternal, foetal, short-term neonatal and placental histopathologic findings of a retrospective cohort of pregnant women with either pre-gestational (group 1) or GBC (group 2) from a tertiary-level maternity care centre. Of the 69 women identified over 12 years, there were 47 in group 1 and 22 in group 2...
September 14, 2018: Gynecologic and Obstetric Investigation
Ngozi N Joe-Ikechebelu, George Uchenna Eleje, Emmanuel Onyebuchi Ugwu, Chidimma Donatus Okafor, Cyril Emeka Nwachukwu, Princeston C Okam, Obinna E Ogboji, Joseph Ifeanyichukwu Ikechebelu
BACKGROUND/AIMS: To compare the efficacy and safety of trocar-site infiltration with lidocaine and no intervention for postoperative pain relief after diagnostic laparoscopy. METHODS: A randomized clinical trial of women with infertility scheduled for diagnostic laparoscopy without additional procedures in Life Institute for Endoscopy at Life Specialist Hospital, Nnewi, Nigeria. One hundred and ninety nine women were assigned at random to either trocar-site infiltration with lidocaine (n = 100) or no intervention (n = 99)...
August 24, 2018: Gynecologic and Obstetric Investigation
Wenping Sun, Liehong Wang, Dexiong Zhao, Pinhua Wang, Yongping Li, Shulin Wang
BACKGROUND/AIMS: Circulation long non-coding RNAs (lncRNAs) have emerged recently as major players in tumor biology and might be applied for cancer diagnosis, prognosis, or potential therapeutic targets. In this study, we aimed to explore whether the circulation lncRNA could predict the tumorigenesis of surgical squamous cervical cancer (CC). METHODS: In this study, we applied the lncRNA microarray to screen the potential biomarker for CC. Real-time quantitate polymerase chain reaction was conducted for further validation in a larger sample size...
August 22, 2018: Gynecologic and Obstetric Investigation
Konstantinos Sfakianoudis, Mara Simopoulou, Nikolaos Nitsos, Anna Rapani, Agni Pantou, Terpsithea Vaxevanoglou, Georgia Kokkali, Michael Koutsilieris, Konstantinos Pantos
Poor responders are described as those In Vitro Fertilization (IVF) patients who are failing to respond to controlled ovarian stimulation protocols. Extensive research has focused on crafting the optimal treatment. However, it appears that each approach fails to be established as effective or guaranteed towards successful management. Platelet-Rich Plasma (PRP) is a novel, highly promising approach that has been successfully applied for an array of medical issues. In this case series, we present 3 poor responder patients with the common denominator of: failed IVF attempts, poor oocyte yield, and poor embryo quality...
August 22, 2018: Gynecologic and Obstetric Investigation
Mehmet Ozgur Akkurt, Iltac Akkurt, And Yavuz, Serenat Eris Yalcin, Bora Coskun, Mekin Sezik
AIM: To evaluate the effect of intracardiac potassium chloride feticide procedure (FP) on the induction-to-abortion (I-to-A) interval for various indications in the termination of pregnancy. METHOD: Medically indicated abortions between 17 and 28 weeks' gestation were retrospectively evaluated and allocated into 2 groups: Cases with (group 1, n = 58) or without an FP (group 2, n = 60). I-to-A intervals were compared across the groups, considering different baseline parameters and fetal abnormality categories...
August 10, 2018: Gynecologic and Obstetric Investigation
Niyazi Tug, Mehmet Akif Sargin, Murat Yassa
OBJECTIVE: To investigate the clinical results and prognostic factors of multiple dose methotrexate (Mtx) treatment of ectopic pregnancy patients with high initial serum (human chorionic gonadotropin [hCG]). DESIGN: Retrospective cohort study. PATIENTS: Twenty-six ectopic pregnancy patients with serum (βhCG) > 5,000 mIU/mL who received multiple doses of Mtx (1 mg/kg) with folinic acid rescue on the alternating days. RESULTS: Success rate was 88...
August 10, 2018: Gynecologic and Obstetric Investigation
James C Cripe, Kathryn A Mills, Lindsay K Kuroki, Leping Wan, Andrea R Hagemann, Katherine C Fuh, David G Mutch, Matthew A Powell, Premal H Thaker
OBJECTIVES: Gynecologic oncologists frequently care for patients at the end of life with the aid of palliative care (PC) specialists. Our primary objectives were to identify perceived barriers to integrating specialty PC into gynecologic cancer care. MATERIALS AND METHODS: Members of the Society of Gynecologic Oncology (SGO) were invited to participate in an anonymous online survey. A Likert scale captured perceptions regarding primary and specialty PC, frequent barriers to use of PC, and potential interventions...
August 10, 2018: Gynecologic and Obstetric Investigation
Cihan Kaya, Ismail Alay, Hakan Guraslan, Asuman Gedikbasi, Murat Ekin, Sinem Ertaş Kaya, Engin Oral, Levent Yasar
BACKGROUND/AIMS: To identify the role of serum caspase 3, Annexin A2 (ANXA2), and Soluble Fas Ligand (sFasL) levels in the prediction of endometriosis severity. METHODS: The study was performed on 90 women who were candidates for laparoscopic surgery due to endometrioma or any other benign ovarian cysts detected by ultrasound examination, pelvic pain, or infertility. The control group comprised 29  patients. The second group comprised 29 patients with stage I-II endometriosis and the third group comprised 30 patients with stage III-IV endometriosis...
August 2, 2018: Gynecologic and Obstetric Investigation
Rina Tamir Yaniv, Ron Schonmann, Regina Agizim, Merav Sharvit, Einat Haikin Herzberger, Yair Daykan, Zvi Klein, Togas Tulandi, Amir Wiser
STUDY OBJECTIVE: The study aimed to evaluate whether there is an association between the ovarian ligament length and ovarian torsion. DESIGN: This is a prospective cohort study. Design Classification: II.2. SETTING: The study was conducted in the gynecology department of a university affiliated hospital. INTERVENTION: We measured the length of the ovarian ligaments during laparoscopy. PATIENTS: A total of 56 women were recruited, of which 28 women were operated for ovarian torsion (torsion group) and 28 others for other gynecologic conditions (control group)...
August 2, 2018: Gynecologic and Obstetric Investigation
Christos Dragamestianos, Christina I Messini, Pantelis T Antonakis, Konstantina Zacharouli, Evanthia Kostopoulou, Antonis Makrigiannakis, Panagiotis Georgoulias, George Anifandis, Konstantinos Dafopoulos, Antonios Garas, Alexandros Daponte, Ioannis E Messinis
OBJECTIVES: To investigate the effect of metformin on endometrial receptivity in women with polycystic ovary syndrome (PCOS). METHODS: Twenty volunteer women with polycystic ovaries and oligomenorrhea were prospectively investigated. All women were treated with exogenous estradiol and progesterone to simulate a normal menstrual cycle (28-day duration) after GnRH-induced pituitary desensitization. Ten of the women received no other medication (group A, control), while the remaining 10 received metformin (group B, metformin)...
July 26, 2018: Gynecologic and Obstetric Investigation
Ronit Beck-Fruchter, Shira Baram, Yoel Geslevich, Amir Weiss
BACKGROUND/AIMS: Gonadotropin releasing hormone (GnRH) agonist triggering results in an endogenous gonadotropin flare. Although it effectively stimulates ovulation, GnRH agonist triggers results in an early luteolysis and requires modification of the luteal support. The current study aims to evaluate GnRH agonist triggering with exclusive human chorionic gonadotropin (hCG) luteal support. METHODS: In this prospective observational study, 56 normogonadotropic-assisted reproductive technology patients, stimulated using a GnRH-antagonist protocol, were studied...
July 26, 2018: Gynecologic and Obstetric Investigation
Yuval Fouks, Ariel Many, Sharon Amit, Isahai Levin, Amir Meiri, Shiri Shinar
AIMS: The study aimed to compare the clinical course and disease severity between culture positive and culture negative patients with intra-uterine devices (IUD)-associated pelvic inflammatory disease (PID). METHODS: A retrospective study of all IUD-associated PID patients admitted to tertiary medical center between 2010 and 2015. All patients received standard empiric antibiotic therapy upon admission. The study cohort was divided into 2: patients with culture positive IUDs and patients with negative cultures...
July 25, 2018: Gynecologic and Obstetric Investigation
Lisa B E Shields, Mary E Gordinier
Advanced vulvar cancer is associated with a very poor prognosis. Surgical resection is the mainstay of treatment, with radiation indicated for areas at high risk for recurrence. When surgical and radiation options have been exhausted, the effectiveness of systemic chemotherapy is poor. No biologic or targeted agents have been approved for the management of advanced or recurrent vulvar cancer. Pembrolizumab, a humanized monoclonal antibody against programmed death 1 (PD-1), has been successfully used as a target of tumor immune therapy in small cell lung cancer and melanoma...
July 17, 2018: Gynecologic and Obstetric Investigation
Jorge Valencia-Ortega, Arturo Zárate, Renata Saucedo, Marcelino Hernández-Valencia, José G Cruz, Edgardo Puello
OBJECTIVE: To evaluate the placental and decidual gene expression and maternal and umbilical serum concentrations of tumor necrosis factor alpha, interleukin 6 (IL-6), IL-8, IL-10, IL-1 receptor antagonist (IL-1RA), intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 (VCAM-1), along with the proinflammatory/anti-inflammatory cytokine ratios in women with preeclampsia (PE) vs. women with normal pregnancy (NP), and to analyze PE classified as early- (EO) and late-onset (LO)...
July 13, 2018: Gynecologic and Obstetric Investigation
Shahar Kol
Gonadotropin-releasing hormone (GnRH) antagonist-based ovarian stimulation protocol is gaining popularity. This protocol allows for the use of GnRH agonist as a trigger of final oocyte maturation, instead of the "gold standard" human chorionic gonadotropin (hCG) trigger. GnRH agonist trigger causes quick luteolysis, hence its widespread use in the context of ovarian hyperstimulation syndrome (OHSS) prevention. To secure pregnancy post GnRH agonist trigger, the luteal phase must be supplemented to counteract the luteolysis...
July 13, 2018: Gynecologic and Obstetric Investigation
Augusto Pereira, Tirso Pérez-Medina, Ana Rodríguez-Tapia, Yoana Chiverto, Santiago Lizarraga
BACKGROUND: The objective was to describe clinical findings and outcomes of patients with pudendal neuralgia in relation with the anatomical segment affected. METHODS: Fifty-one consecutive patients with chronic perineal pain (CPP) located in the areas supplied by the pudendal nerve (PN), from January 2011 to June 2012, were analyzed. RESULTS: The distribution of pain at perineal, dorsal clitoris and inferior anal nerves was 92.2, 31.4 and 25...
July 13, 2018: Gynecologic and Obstetric Investigation
Ebru Ersoy, Sibel Özler, Efser Öztaş, Ali Özgür Ersoy, Merve Ergin, Aytekin Tokmak, Nafiye Yilmaz
BACKGROUND/AIMS: A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) enzymes take part in extracellular matrix (ECM) remodeling which has been shown to contribute to the ovulation and follicular functions. We aimed to compare serum levels of ADAMTS-19 in patients with different fertility situations. METHODS: A total of 86 women were enrolled to this cross sectional and case-control study. Four groups were constituted with respect to women's clinical and hormonal status: group 1, women with premature ovarian failure (POF; n = 21); group 2, women with natural menopause (n = 21); group 3, women with polycystic ovary syndrome (PCOS; n = 22); and group 4, healthy fertile controls...
July 6, 2018: Gynecologic and Obstetric Investigation
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