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Hearing Research

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https://www.readbyqxmd.com/read/29150051/glutamate-is-down-regulated-and-tinnitus-loudness-levels-decreased-following-rtms-over-auditory-cortex-of-the-left-hemisphere-a-prospective-randomized-single-blinded-sham-controlled-cross-over-study
#1
Anthony T Cacace, Jiani Hu, Stephen Romero, Yang Xuan, Robert F Burkard, Richard S Tyler
Using a prospective randomized single-blinded sham-controlled cross-over design, we studied the efficacy of low frequency (1-Hz) repetitive transcranial magnetic stimulation (rTMS) over auditory cortex of the left temporal lobe as an experimental treatment modality for noise-induced tinnitus. Pre/post outcome measures for sham vs. active rTMS conditions included differential changes in tinnitus loudness, self-perceived changes in the Tinnitus Handicap Questionnaire (THQ), and neurochemical changes of brain metabolite concentrations using single voxel proton magnetic resonance spectroscopy ((1)H-MRS) obtained from left and right auditory cortical areas...
November 14, 2017: Hearing Research
https://www.readbyqxmd.com/read/29149722/effects-of-middle-ear-quasi-static-stiffness-on-sound-transmission-quantified-by-a-novel-3-axis-optical-force-sensor
#2
Ivo Dobrev, Jae Hoon Sim, Baktash Aqtashi, Alexander M Huber, Thomas Linder, Christof Röösli
BACKGROUND: Intra-operative quantification of the ossicle mobility could provide valuable feedback for the current status of the patient's conductive hearing. However, current methods for evaluation of middle ear mobility are mostly limited to the surgeon's subjective impression through manual palpation of the ossicles. This study investigates how middle ear transfer function is affected by stapes quasi-static stiffness of the ossicular chain. The stiffness of the middle ear is induced by a) using a novel fiber-optic 3-axis force sensor to quantify the quasi-static stiffness of the middle ear, and b) by artificial reduction of stapes mobility due to drying of the middle ear...
November 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/29129348/performance-of-the-tinnitus-functional-index-as-a-diagnostic-instrument-in-a-uk-clinical-population
#3
Kathryn Fackrell, Deborah A Hall, Johanna G Barry, Derek J Hoare
OBJECTIVES: The Tinnitus Functional Index (TFI) has been optimised as a diagnostic tool for quantifying the functional impact of tinnitus in US veteran and civilian groups. However, the TFI has not been fully evaluated for use in other English-speaking clinical populations despite its increasingly popular uptake. Here, a prospective multi-site longitudinal validation study was conducted to evaluate psychometric properties relevant to the UK clinical population. Guided by quality criteria for the measurement properties of health-related questionnaires, we specifically evaluated three diagnostic properties relating to the degree to which the TFI (i) covers the eight dimensions proposed to be important for diagnosis, (ii) reliably distinguishes individual differences in severity of tinnitus, and (iii) reliably measures the functional impact of tinnitus...
November 9, 2017: Hearing Research
https://www.readbyqxmd.com/read/29128159/development-of-the-head-pinnae-and-acoustical-cues-to-sound-location-in-a-precocial-species-the-guinea-pig-cavia-porcellus
#4
Kelsey L Anbuhl, Victor Benichoux, Nathaniel T Greene, Andrew D Brown, Daniel J Tollin
The morphology of the head and pinna shape the spatial and frequency dependence of sound propagation that give rise to the acoustic cues to sound source location. During early development, the physical dimensions of the head and pinna increase rapidly. Thus, the binaural (interaural time and level differences, ITD and ILD) and monaural (spectral shape) cues are also hypothesized to change rapidly. Complex interactions between the size and shape of the head and pinna limit the accuracy of simple acoustical models (e...
November 1, 2017: Hearing Research
https://www.readbyqxmd.com/read/29133013/the-optimal-inter-implant-interval-in-pediatric-sequential-bilateral-implantation
#5
Angelika Illg, Carolin Sandner, Andreas Büchner, Thomas Lenarz, Andrej Kral, Anke Lesinski-Schiedat
An increasing number of children receive bilateral cochlear implants (CIs) sequentially. Outcomes of bilateral implantation show high variability. This retrospective analysis investigates the optimal inter-implant interval. For this purpose, speech comprehension results of 250 children who underwent sequential bilateral cochlear implantation were evaluated. All individuals underwent periodic speech perception testing in quiet and noise. The most recent unilateral data for each side were statistically analyzed...
October 31, 2017: Hearing Research
https://www.readbyqxmd.com/read/29126650/plasticity-in-the-auditory-system
#6
REVIEW
Dexter R F Irvine
Over the last 30 years a wide range of manipulations of auditory input and experience have been shown to result in plasticity in auditory cortical and subcortical structures. The time course of plasticity ranges from very rapid stimulus-specific adaptation to longer-term changes associated with, for example, partial hearing loss or perceptual learning. Evidence for plasticity as a consequence of these and a range of other manipulations of auditory input and/or its significance is reviewed, with an emphasis on plasticity in adults and in the auditory cortex...
October 31, 2017: Hearing Research
https://www.readbyqxmd.com/read/29108871/effects-of-the-cannabinoid-cb1-agonist-acea-on-salicylate-ototoxicity-hyperacusis-and-tinnitus-in-guinea-pigs
#7
Joel I Berger, Ben Coomber, Samantha Hill, Steve P H Alexander, William Owen, Alan R Palmer, Mark N Wallace
Cannabinoids have been suggested as a therapeutic target for a variety of brain disorders. Despite the presence of their receptors throughout the auditory system, little is known about how cannabinoids affect auditory function. We sought to determine whether administration of arachidonyl-2'-chloroethylamide (ACEA), a highly-selective CB1 agonist, could attenuate a variety of auditory effects caused by prior administration of salicylate, and potentially treat tinnitus. We recorded cortical resting-state activity, auditory-evoked cortical activity and auditory brainstem responses (ABRs), from chronically-implanted awake guinea pigs, before and after salicylate + ACEA...
October 31, 2017: Hearing Research
https://www.readbyqxmd.com/read/29097049/the-absence-of-resting-state-high-gamma-cross-frequency-coupling-in-patients-with-tinnitus
#8
Min-Hee Ahn, Sung Kwang Hong, Byoung-Kyong Min
Tinnitus is a psychoacoustic phantom perception of currently unknown neuropathology. Despite a growing number of post-stimulus tinnitus studies, uncertainty still exists regarding the neural signature of tinnitus in the resting-state brain. In the present study, we used high-gamma cross-frequency coupling and a Granger causality analysis to evaluate resting-state electroencephalographic (EEG) data in healthy participants and patients with tinnitus. Patients with tinnitus lacked robust frontal delta-phase/central high-gamma-amplitude coupling that was otherwise clearly observed in healthy participants...
October 30, 2017: Hearing Research
https://www.readbyqxmd.com/read/29089185/cannula-based-drug-delivery-to-the-guinea-pig-round-window-causes-a-lasting-hearing-loss-that-may-be-temporarily-mitigated-by-bdnf
#9
Phillip J P Sale, Aaron Uschakov, Tasfia Saief, David P Rowe, Carla J Abbott, Chi D Luu, Amy J Hampson, Stephen J O'Leary, David J Sly
Sustained local delivery of drugs to the inner ear may be required for future regenerative and protective strategies. The round window is surgically accessible and a promising delivery route. To be viable, a delivery system should not cause hearing loss. This study determined the effect on hearing of placing a drug-delivery microcatheter on to the round window, and delivering either artificial perilymph (AP) or brain-derived neurotrophic factor (BDNF) via this catheter with a mini-osmotic pump. Auditory brainstem responses (ABRs) were monitored for 4 months after surgery, while the AP or BDNF was administered for the first month...
October 28, 2017: Hearing Research
https://www.readbyqxmd.com/read/29122423/efferent-modulation-of-pre-neural-and-neural-distortion-products
#10
S B Smith, K Ichiba, D S Velenovsky, B Cone
Distortion product otoacoustic emissions (DPOAEs) and distortion product frequency following responses (DPFFRs) are respectively pre-neural and neural measurements associated with cochlear nonlinearity. Because cochlear nonlinearity is putatively linked to outer hair cell electromotility, DPOAEs and DPFFRs may provide complementary measurements of the human medial olivocochlear (MOC) reflex, which directly modulates outer hair cell function. In this study, we first quantified MOC reflex-induced DPOAE inhibition at spectral fine structure peaks in 22 young human adults with normal hearing...
October 26, 2017: Hearing Research
https://www.readbyqxmd.com/read/29126651/effects-of-noise-exposure-on-young-adults-with-normal-audiograms-ii-behavioral-measures
#11
Garreth Prendergast, Rebecca E Millman, Hannah Guest, Kevin J Munro, Karolina Kluk, Rebecca S Dewey, Deborah A Hall, Michael G Heinz, Christopher J Plack
An estimate of lifetime noise exposure was used as the primary predictor of performance on a range of behavioral tasks: frequency and intensity difference limens, amplitude modulation detection, interaural phase discrimination, the digit triplet speech test, the co-ordinate response speech measure, an auditory localization task, a musical consonance task and a subjective report of hearing ability. One hundred and thirty-eight participants (81 females) aged 18-36 years were tested, with a wide range of self-reported noise exposure...
October 25, 2017: Hearing Research
https://www.readbyqxmd.com/read/29102129/an-overview-of-cochlear-implant-electrode-array-designs
#12
REVIEW
Anandhan Dhanasingh, Claude Jolly
Cochlear implant electrode arrays are designed with specific characteristics that allow for the preservation of intra-cochlear structures during the insertion process, as well as during explantation. Straight lateral wall (LW) electrode arrays and pre-curved modiolar hugging (MH) electrode arrays are the two types that are commercially available. Although there is a third type of electrode array called the mid-scala (MS), which is positioned in the middle of the scala tympani (ST), and is usually considered as an MH type of electrode...
October 18, 2017: Hearing Research
https://www.readbyqxmd.com/read/29074265/the-effect-of-illusionary-perception-on-mismatch-negativity-mmn-an-electroencephalography-study
#13
Kentaro Ono, Daiki Yamasaki, Christian F Altmann, Tatsuya Mima
Mismatch negativity (MMN) is a unique brain response elicited by any discernible change of features in a tone sequence. Although the occurrence of MMN is dependent upon the difference of a stimulus parameter, such as frequency or intensity, recent studies have suggested that MMN occurs as a result of a comparison between an internal representation created by perception and an incoming tone. The present study aimed to investigate MMN occurs based upon the physical properties of stimuli or as a result of the perception of the scale illusion...
October 17, 2017: Hearing Research
https://www.readbyqxmd.com/read/29056432/tinnitus-with-a-normal-audiogram-role-of-high-frequency-sensitivity-and-reanalysis-of-brainstem-response-measures-to-avoid-audiometric-over-matching
#14
LETTER
Hannah Guest, Kevin J Munro, Christopher J Plack
No abstract text is available yet for this article.
October 14, 2017: Hearing Research
https://www.readbyqxmd.com/read/29133012/tinnitus-related-fear-mediating-the-effects-of-a-cognitive-behavioural-specialised-tinnitus-treatment
#15
Rilana F F Cima, Gerard van Breukelen, Johan W S Vlaeyen
OBJECTIVE: Cognitive behavioural treatments (CBT) for the reduction of tinnitus complaints have been shown to be effective; however the specific mechanisms of change are yet to be unveiled. Reductions in tinnitus-related fear have been indicated to be an important factor in alleviating tinnitus suffering. The role of tinnitus-related fear has been proposed as a mediator explaining the cognitive behavioural treatment effects on tinnitus severity, tinnitus-related impairment and general quality of life of tinnitus patients...
October 12, 2017: Hearing Research
https://www.readbyqxmd.com/read/29042121/auditory-sequential-accumulation-of-spectral-information
#16
Yi Shen
In many listening situations, information about the spectral content of a target sound may be distributed over time, and estimating the target spectrum requires efficient sequential processing. Listeners' ability to estimate the spectrum of a random-frequency, six-tone complex was investigated and the spectral content of the complex was revealed using a sequence of bursts. Whether each of the six tones was presented within each burst was determined at random according to a presentation probability. In separate conditions, the presentation probabilities (p) ranged from 0...
October 11, 2017: Hearing Research
https://www.readbyqxmd.com/read/29056431/effects-of-surgical-lesions-on-choline-acetyltransferase-activity-in-the-cat-cochlea
#17
Mark J Frilling, Gregory J Wiet, Donald A Godfrey, Judy A Parli, Jon D Dunn, C David Ross
Although it is well established that the choline acetyltransferase (ChAT, the enzyme for acetylcholine synthesis) in the mammalian cochlea is associated with its olivocochlear innervation, the distribution of this innervation in the cochlea varies somewhat among mammalian species. The quantitative distribution of ChAT activity in the cochlea has been reported for guinea pigs and rats. The present study reports the distribution of ChAT activity within the organ of Corti among the three turns of the cat cochlea and the effects of removing olivocochlear innervation either by a lateral cut aimed to totally transect the left olivocochlear bundle or a more medial cut additionally damaging the superior olivary complex on the same side...
October 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/29037815/an-operating-principle-of-the-turtle-utricle-to-detect-wide-dynamic-range
#18
Jong-Hoon Nam
The utricle encodes both static information such as head orientation, and dynamic information such as vibrations. It is not well understood how the utricle can encode both static and dynamic information for a wide dynamic range (from <0.05 to >2 times the gravitational acceleration; from DC to > 1000 Hz vibrations). Using computational models of the hair cells in the turtle utricle, this study presents an explanation on how the turtle utricle encodes stimulations over such a wide dynamic range. Two hair bundles were modeled using the finite element method-one representing the striolar hair cell (Cell S), and the other representing the medial extrastriolar hair cell (Cell E)...
October 9, 2017: Hearing Research
https://www.readbyqxmd.com/read/28987787/tonotopic-organisation-of-the-auditory-cortex-in-sloping-sensorineural-hearing-loss
#19
Tomasz Wolak, Katarzyna Cieśla, Artur Lorens, Krzysztof Kochanek, Monika Lewandowska, Mateusz Rusiniak, Agnieszka Pluta, Joanna Wójcik, Henryk Skarżyński
Although the tonotopic organisation of the human primary auditory cortex (PAC) has already been studied, the question how its responses are affected in sensorineural hearing loss remains open. Twenty six patients (aged 38.1 ± 9.1 years; 12 men) with symmetrical sloping sensorineural hearing loss (SNHL) and 32 age- and gender-matched controls (NH) participated in an fMRI study using a sparse protocol. The stimuli were binaural 8s complex tones with central frequencies of 400 HzCF, 800 HzCF, 1600 HzCF, 3200 HzCF, or 6400 HzCF, presented at 80 dB(C)...
September 28, 2017: Hearing Research
https://www.readbyqxmd.com/read/28974383/a-nonsynonymous-mutation-in-the-wfs1-gene-in-a-finnish-family-with-age-related-hearing-impairment
#20
Laura Kytövuori, Samuli Hannula, Elina Mäki-Torkko, Martti Sorri, Kari Majamaa
Wolfram syndrome (WS) is caused by recessive mutations in the Wolfram syndrome 1 (WFS1) gene. Sensorineural hearing impairment (HI) is a frequent feature in WS and, furthermore, certain mutations in WFS1 cause nonsyndromic dominantly inherited low-frequency sensorineural HI. These two phenotypes are clinically distinct indicating that WFS1 is a reasonable candidate for genetic studies in patients with other phenotypes of HI. Here we have investigated, whether the variation in WFS1 has a pathogenic role in age-related hearing impairment (ARHI)...
September 28, 2017: Hearing Research
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