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Hearing Research

Bo Ding, Joseph P Walton, Xiaoxia Zhu, Robert D Frisina
Due to the critical role of cochlear ion channels for hearing, the focus of the present study was to examine age-related changes of Na, K-ATPase (NKA) subunits in the lateral wall of mouse cochlea. We combined qRT-PCR, western blot and immunocytochemistry methodologies in order to determine gene and protein expression levels in the lateral wall of young and aged CBA/CaJ mice. Of the seven NKA subunits, only the mRNA expressions of α1, β1 and β2 subunit isoforms were detected in the lateral wall of CBA/CaJ mice...
July 10, 2018: Hearing Research
Luise Weinrich, Mandy Sonntag, Thomas Arendt, Markus Morawski
The human auditory brainstem, especially the cochlear nucleus (CN) and the superior olivary complex (SOC) are characterized by a high density of neurons associated with perineuronal nets (PNs). PNs build a specific form of extracellular matrix surrounding the neuronal somata, proximal dendrites and axon initial segments. They restrict synaptic plasticity and control high-frequency synaptic activity, a prominent characteristic of neurons of the auditory brainstem. The distribution of PNs within the auditory brainstem has been investigated in a number of mammalian species...
July 10, 2018: Hearing Research
Kohei Yamahara, Koji Nishimura, Hideaki Ogita, Juichi Ito, Takayuki Nakagawa, Ichiro Furuta, Tomoko Kita, Koichi Omori, Norio Yamamoto
The hybrid or electric-acoustic stimulation cochlear implant is indicated in patients with a residual hearing at low frequencies. It provides electric and acoustic stimulation for compensating for high- and low-frequency sounds, respectively. However, the implantation procedure damages the cochlea, resulting in loss of the residual-hearing and diminished effects of the acoustic-hearing in several patients. To prevent hearing loss after implantation, corticosteroids have been used clinically although their effects are limited...
July 6, 2018: Hearing Research
Laura Jagoda, Nathalie Giroud, Patrick Neff, Andrea Kegel, Tobias Kleinjung, Martin Meyer
Individuals suffering from tinnitus often complain about difficulties understanding speech in noisy environments even in the absence of a peripheral hearing loss. This EEG study aimed to investigate whether aspects of phonetic perception are affected by the experience of tinnitus. We examined a sample of individuals with chronic, subjective tinnitus (n = 30, age range 30-50 yrs.), who underwent behavioural screening (standard tinnitus questionnaires) and comprehensive audiometric testing that covered peripheral and central hearing abilities (pure tone audiometry, suprathreshold audiometry (frequency selectivity and temporal compression), and speech in noise performance)...
July 5, 2018: Hearing Research
Rajeev Mathew, Deborah Vickers, Patrick Boyle, Azhar Shaida, David Selvadurai, Dan Jiang, Jaime Undurraga
The plasticity of the auditory system enables it to adjust to electrical stimulation from cochlear implants (CI). Whilst speech perception may develop for many years after implant activation, very little is known about the changes in auditory processing that underpin these improvements. Such an understanding could help guide interventions that improve hearing performance. In this longitudinal study, we examine how electrode discrimination ability changes over time in newly implanted adult CI users. Electrode discrimination was measured with a behavioural task as well as the spatial auditory change complex (ACC), which is a cortical response to a change in place of stimulation...
July 4, 2018: Hearing Research
William P Shofner, Hayley Morris, Mackenzie Mills
When a wideband harmonic tone complex (wHTC) is passed through a noise vocoder, the resulting sounds can have spectra with large peak-to-valley ratios, but little or no periodicity strength in the autocorrelation functions. We measured judgments of pitch strength for normal-hearing listeners for noise-vocoded wideband harmonic tone complexes (NV-wHTCs) relative to standard and anchor stimuli. The standard was a 1-channel NV-wHTC and the anchor was either the unprocessed wHTC or an infinitely-iterated rippled noise (IIRN)...
July 4, 2018: Hearing Research
Darcy L Frear, Xiying Guan, Christof Stieger, John J Rosowski, Hideko Heidi Nakajima
For almost a decade, we have measured intracochlear sound pressures evoked by air conducted (AC) sound presented to the ear canal in many fresh human cadaveric specimens. Similar measurements were also obtained during round window (RW) mechanical stimulation in multiple specimens. In the present study, we use our accumulated data of intracochlear pressures and simultaneous velocity measurements of the stapes or RW to determine acoustic impedances of the cochlear partition, RW, and the leakage paths from scala vestibuli and scala tympani, as well as the reverse middle ear impedance...
June 30, 2018: Hearing Research
Stefan K Plontke, Alec N Salt
No abstract text is available yet for this article.
June 28, 2018: Hearing Research
Amielle Moreno, Ankita Gumaste, Geoff K Adams, Kelly K Chong, Michael Nguyen, Kathryn N Shepard, Robert C Liu
When a social sound category initially gains behavioral significance to an animal, plasticity events presumably enhance the ability to recognize that sound category in the future. In the context of learning natural social stimuli, neuromodulators such as norepinephrine and estrogen have been associated with experience-dependent plasticity and processing of newly salient social cues, yet continued plasticity once stimuli are familiar could disrupt the stability of sensorineural representations. Here we employed a maternal mouse model of natural sensory cortical plasticity for infant vocalizations to ask whether the engagement of the noradrenergic locus coeruleus (LC) by the playback of pup-calls is affected by either prior experience with the sounds or estrogen availability, using a well-studied cellular activity and plasticity marker, the immediate early gene c-Fos...
June 28, 2018: Hearing Research
Damien Bonnard, Adam Schwalje, Bruce Gantz, Inyong Choi
BACKGROUND: Pitch perception of complex tones relies on place or temporal fine structure-based mechanisms from resolved harmonics and the temporal envelope of unresolved harmonics. Combining this information is essential for speech-in-noise performance, as it allows segregation of a target speaker from background noise. In hybrid cochlear implant (H-CI) users, low frequency acoustic hearing should provide pitch from resolved harmonics while high frequency electric hearing should provide temporal envelope pitch from unresolved harmonics...
June 28, 2018: Hearing Research
Jae Joon Han, Ho Sun Lee, Min-Hyun Park
Neural plasticity is a characteristic of the brain that helps it adapt to changes in sensory input. We hypothesize that auditory deafferentation may induce plastic changes in the cytoskeleton of the neurons in the inferior colliculus (IC). In this study, we evaluated the dynamic status of neurofilament (NF) phosphorylation in the IC after hearing loss. We induced auditory deafferentation via unilateral or bilateral cochlear ablation in rats, aged 4 weeks. To evaluate cytoskeletal changes in neurons, we evaluated mRNA fold changes in NF heavy chain expression, non-phosphorylated NF protein fold changes using SMI-32 antibody, and the ratio of SMI-32 immunoreactive (SMI-32-ir) neurons to the total neuronal population in the IC at 4 and 12 weeks after deafness...
June 23, 2018: Hearing Research
John Peacock, Mohamed Al Hussaini, Nathaniel T Greene, Daniel J Tollin
Exposure to high intensity (blast) sounds can result in both conductive and sensorineural damage to hearing. This includes rupture of the tympanic membrane and dislocation of the middle ear ossicles, as well as damage to the inner and outer hair cells in the cochlea. A clearer understanding of how the hearing system responds to blast could help us better prevent auditory trauma, and support those who have been exposed to such sounds. Chinchillas are often used in studies of hearing due to the similarity between the chinchilla and human audiograms...
June 21, 2018: Hearing Research
Jennifer Schulze, Susanne Sasse, Nils Prenzler, Hinrich Staecker, Adam J Mellott, Ariane Roemer, Martin Durisin, Thomas Lenarz, Athanasia Warnecke
Transplantation of mesenchymal stromal cells (MSC) presents a promising approach not only for the replacement of lost or degenerated cells in diseased organs but also for local drug delivery. It can potentially be used to enhance the safety and efficacy of inner ear surgeries such as cochlear implantation. Options for enhancing the effects of MSC therapy include modulating cell behaviour with customized bio-matrixes or modulating their behaviour by ex vivo transfection of the cells with a variety of genes...
June 21, 2018: Hearing Research
Suzanne H Kimball, Gurjit Singh, Andrew B John, Lorienne M Jenstad
In a relatively short period of time, modern societies have been transformed by the ubiquitous uptake of advanced and portable mobile communication, computation, and sensors available on smartphones. Looking forward, it is anticipated that smartphones will have an increasingly important role in health management including the delivery of hearing healthcare and operation of hearing instruments. OBJECTIVE: This paper provides a brief overview of the role of smartphones in audiologic rehabilitation and hearing research and reports on the findings of a survey assessing attitudes of audiologists towards smartphone integration in hearing healthcare...
June 19, 2018: Hearing Research
Jana Besser, Maren Stropahl, Emily Urry, Stefan Launer
With increasing age, the risk of developing chronic health conditions also increases, and many older people suffer from multiple co-existing health conditions, i.e., multimorbidity. One common health condition at older age is hearing loss (HL). The current article reflects on the implications for audiological care, when HL is one of several health conditions in a multimorbidity. An overview of health conditions often co-existing with HL, so called comorbidities, is provided, including indications for the strength of the associations...
June 19, 2018: Hearing Research
Barbra H B Timmer, Louise Hickson, Stefan Launer
To obtain real-world insights into the hearing difficulties of individuals, the field of hearing research has recently started to adopt ecological momentary assessment. Using this approach, study participants describe their experiences in real time, in their own natural environment. This paper describes the use of ecological momentary assessment in hearing research to date. Several studies have shown the approach is feasible and has good construct validity for use with adults with hearing impairment and/or tinnitus...
June 19, 2018: Hearing Research
Waldo Nogueira, Benjamin Krüger, Andreas Büchner, Enrique Lopez-Poveda
Cochlear implants (CIs) are being implanted in people with unilateral hearing loss because they can improve speech intelligibility and sound source localization. Though designed to restore the afferent auditory stimulation, the CI possibly restores some efferent effects. The present study aimed at investigating this possibility. Five single-sided deaf CI users with less than 30 dB hearing loss up to 4 kHz in their acoustic ear participated in the study. Absolute thresholds for their acoustic ears were measured for pure tones of 500 and 4000 Hz with durations of 10 and 200 ms in the presence and in the absence of contralateral broadband electrical stimulation (CBES) delivered with the CI...
June 15, 2018: Hearing Research
Valerie Hazan, Outi Tuomainen, Lilian Tu, Jeesun Kim, Chris Davis, Douglas Brungart, Benjamin Sheffield
This study investigated the relation between the intelligibility of conversational and clear speech produced by older and younger adults and (a) the acoustic profile of their speech (b) communication effectiveness. Speech samples from 30 talkers from the elderLUCID corpus were used: 10 young adults (YA), 10 older adults with normal hearing (OANH) and 10 older adults with presbycusis (OAHL). Samples were extracted from recordings made while participants completed a problem-solving cooperative task (diapix) with a conversational partner who could either hear them easily (NORM) or via a simulated hearing loss (HLS), which led talkers to naturally adopt a clear speaking style...
June 15, 2018: Hearing Research
Kazuo Ueda, Tomoya Araki, Yoshitaka Nakajima
We examined the frequency specificity of amplitude envelope patterns in 4 frequency bands, which universally appeared through factor analyses applied to power fluctuations of critical-band filtered speech sounds in 8 different languages/dialects [Ueda and Nakajima (2017). Sci. Rep., 7 (42468)]. A series of 3 perceptual experiments with noise-vocoded speech of Japanese sentences was conducted. Nearly perfect (92-94%) mora recognition was achieved, without any extensive training, in a control condition in which 4-band noise-vocoded speech was employed (Experiments 1-3)...
June 15, 2018: Hearing Research
Sara M K Madsen, Torsten Dau, Brian C J Moore
The ability to segregate sounds from different sound sources is thought to depend on the perceptual salience of differences between the sounds, such as differences in frequency or fundamental frequency (F0). F0 discrimination of complex tones is better for tones with low harmonics than for tones that only contain high harmonics, suggesting greater pitch salience for the former. This leads to the expectation that the sequential stream segregation (streaming) of complex tones should be better for tones with low harmonics than for tones with only high harmonics...
June 12, 2018: Hearing Research
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