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Hearing Research

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https://www.readbyqxmd.com/read/28089734/broadening-the-phenotype-of-dfnb28-mutations-in-triobp-are-associated-with-moderate-stable-hereditary-hearing-impairment
#1
Mieke Wesdorp, Jiddeke M van de Kamp, Erik F Hensen, Margit Schraders, Jaap Oostrik, Helger G Yntema, Ilse Feenstra, Ronald J C Admiraal, Henricus P M Kunst, Mustafa Tekin, Moien Kanaan, Hannie Kremer, Ronald J E Pennings
DFNB28 is characterized by prelingual, severe to profound sensorineural hearing impairment (HI). It is associated with mutations in exon 6 and 7 of TRIOBP and has not been reported in the European population. Here, we describe two isolated cases of Dutch origin with congenital, moderate HI and compound heterozygous mutations in TRIOBP. Three of the mutations are novel, one nonsense mutation (c.5014G>T (p.Gly1672*)) and two frameshift mutations (c.2653del (p.Arg885Alafs*120) and c.3460_3461del (p.Leu1154Alafs*29))...
January 12, 2017: Hearing Research
https://www.readbyqxmd.com/read/28088500/voice-emotion-perception-and-production-in-cochlear-implant-users
#2
REVIEW
N T Jiam, M Caldwell, M L Deroche, M Chatterjee, C J Limb
Voice emotion is a fundamental component of human social interaction and social development. Unfortunately, cochlear implant users are often forced to interface with highly degraded prosodic cues as a result of device constraints in extraction, processing, and transmission. As such, individuals with cochlear implants frequently demonstrate significant difficulty in recognizing voice emotions in comparison to their normal hearing counterparts. Cochlear implant-mediated perception and production of voice emotion is an important but relatively understudied area of research...
January 11, 2017: Hearing Research
https://www.readbyqxmd.com/read/28087419/cochlear-synaptopathy-in-acquired-sensorineural-hearing-loss-manifestations-and-mechanisms
#3
REVIEW
M Charles Liberman, Sharon G Kujawa
Common causes of hearing loss in humans - exposure to loud noise or ototoxic drugs and aging - often damage sensory hair cells, reflected as elevated thresholds on the clinical audiogram. Recent studies in animal models suggest, however, that well before this overt hearing loss can be seen, a more insidious, but likely more common, process is taking place that permanently interrupts synaptic communication between sensory inner hair cells and subsets of cochlear nerve fibers. The silencing of affected neurons alters auditory information processing, whether accompanied by threshold elevations or not, and is a likely contributor to a variety of perceptual abnormalities, including speech-in-noise difficulties, tinnitus and hyperacusis...
January 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/28087418/degeneration-of-auditory-nerve-fibers-in-guinea-pigs-with-severe-sensorineural-hearing-loss
#4
Steven Kroon, Dyan Ramekers, Emma M Smeets, Ferry G J Hendriksen, Sjaak F L Klis, Huib Versnel
Damage to and loss of the organ of Corti leads to secondary degeneration of the spiral ganglion cell (SGC) somata of the auditory nerve. Extensively examined in animal models, this degeneration process of SGC somata following deafening is well known. However, degeneration of auditory nerve axons, which conduct auditory information towards the brainstem, and its relation to SGC soma degeneration are largely unknown. The consequences of degeneration of the axons are relevant for cochlear implantation, which is applied to a deafened system but depends on the condition of the auditory nerve...
January 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/28087417/culture-media-based-selection-of-endothelial-cells-pericytes-and-perivascular-resident-macrophage-like-melanocytes-from-the-young-mouse-vestibular-system
#5
Jinhui Zhang, Songlin Chen, Jing Cai, Zhiqiang Hou, Xiaohan Wang, Allan Kachelmeier, Xiaorui Shi
The vestibular blood-labyrinth barrier (BLB) is comprised of perivascular-resident macrophage-like melanocytes (PVM/Ms) and pericytes (PCs), in addition to endothelial cells (ECs) and basement membrane (BM), and bears strong resemblance to the cochlear BLB in the stria vascularis. Over the past few decades, in vitro cell-based models have been widely used in blood-brain barrier (BBB) and blood-retina barrier (BRB) research, and have proved to be powerful tools for studying cell-cell interactions in their respective organs...
January 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/28087416/the-path-of-a-click-stimulus-from-ear-canal-to-umbo
#6
Mario Milazzo, Elika Fallah, Michael Carapezza, Nina S Kumar, Jason H Lei, Elizabeth S Olson
The tympanic membrane (TM) has a key role in transmitting sounds to the inner ear, but a concise description of how the TM performs this function remains elusive. This paper probes TM operation by applying a free field click stimulus to the gerbil ear and exploring the consequent motions of the TM and umbo. Motions of the TM were measured both on radial tracks starting close to the umbo and on a grid distal and adjacent to the umbo. The experimental results confirmed the high fidelity of sound transmission from the ear canal to the umbo...
January 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/28087415/estimation-of-the-young-s-modulus-of-the-human-pars-tensa-using-in-situ-pressurization-and-inverse-finite-element-analysis
#7
S Alireza Rohani, Soroush Ghomashchi, Sumit K Agrawal, Hanif M Ladak
Finite-element models of the tympanic membrane are sensitive to the Young's modulus of the pars tensa. The aim of this work is to estimate the Young's modulus under a different experimental paradigm than currently used on the human tympanic membrane. These additional values could potentially be used by the auditory biomechanics community for building consensus. The Young's modulus of the human pars tensa was estimated through inverse finite-element modelling of an in-situ pressurization experiment. The experiments were performed on three specimens with a custom-built pressurization unit at a quasi-static pressure of 500 Pa...
January 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/28077280/engineering-out-the-noise
#8
Kurt Yankaskas, Raymond Fischer, Jesse Spence, Jeff Komrower
The US Navy, through an Office of Naval Research (ONR) lead effort on Noise Induced Hearing Loss (NIHL), is investigating methods and techniques to mitigate hearing loss for the crews and warfighters. Hearing protection is a viable and increasingly popular method of reducing hearing exposure for many ship crewmembers; however, it has limitations on comfort and low frequency effectiveness. Furthermore, Personal Hearing Protection (PHP) is often used improperly. Proper vessel planning, programmatic changes and advances in noise control engineering can also have significant impacts by inherently reducing noise exposure through ship design and use of noise control treatments...
January 7, 2017: Hearing Research
https://www.readbyqxmd.com/read/28069376/translational-issues-in-cochlear-synaptopathy
#9
REVIEW
Ann E Hickox, Erik Larsen, Michael G Heinz, Leslie Shinobu, Jonathon P Whitton
Understanding the biology of the previously underappreciated sensitivity of cochlear synapses to noise insult, and its clinical consequences, is becoming a mission for a growing number of auditory researchers. In addition, several research groups have become interested in developing therapeutic approaches that can reverse synaptopathy and restore hearing function. One of the major challenges to realizing the potential of synaptopathy rodent models is that current clinical audiometric approaches cannot yet reveal the presence of this subtle cochlear pathology in humans...
January 6, 2017: Hearing Research
https://www.readbyqxmd.com/read/28065805/genetic-perturbations-suggest-a-role-of-the-resting-potential-in-regulating-the-expression-of-the-ion-channels-of-the-kcna-and-hcn-families-in-octopus-cells-of-the-ventral-cochlear-nucleus
#10
Xiao-Jie Cao, Donata Oertel
Low-voltage-activated K(+) (gKL) and hyperpolarization-activated mixed cation conductances (gh) mediate currents, IKL and Ih, through channels of the Kv1 (KCNA) and HCN families respectively and give auditory neurons the temporal precision required for signaling information about the onset, fine structure, and time of arrival of sounds. Being partially activated at rest, gKL and gh contribute to the resting potential and shape responses to even small subthreshold synaptic currents. Resting gKL and gh also affect the coupling of somatic depolarization with the generation of action potentials...
January 5, 2017: Hearing Research
https://www.readbyqxmd.com/read/28057487/contralateral-electrically-evoked-suppression-of-transient-evoked-otoacoustic-emissions-in-single-sided-deaf-patients
#11
Oliver Christian Dziemba, Daniel Grafmans, Stephan Merz, Thomas Hocke
No abstract text is available yet for this article.
January 3, 2017: Hearing Research
https://www.readbyqxmd.com/read/28043881/simultaneously-evoked-auditory-potentials-seap-a-new-method-for-concurrent-measurement-of-cortical-and-subcortical-auditory-evoked-activity
#12
Christopher Slugocki, Daniel Bosnyak, Laurel J Trainor
Recent electrophysiological work has evinced a capacity for plasticity in subcortical auditory nuclei in human listeners. Similar plastic effects have been measured in cortically-generated auditory potentials but it is unclear how the two interact. Here we present Simultaneously-Evoked Auditory Potentials (SEAP), a method designed to concurrently elicit electrophysiological brain potentials from inferior colliculus, thalamus, and primary and secondary auditory cortices. Twenty-six normal-hearing adult subjects (mean 19...
December 30, 2016: Hearing Research
https://www.readbyqxmd.com/read/28034618/adenosine-receptors-regulate-susceptibility-to-noise-induced-neural-injury-in-the-mouse-cochlea-and-hearing-loss
#13
Srdjan M Vlajkovic, Kaushi Ambepitiya, Meagan Barclay, Detlev Boison, Gary D Housley, Peter R Thorne
Our previous studies have shown that the stimulation of A1 adenosine receptors in the inner ear can mitigate the loss of sensory hair cells and hearing loss caused by exposure to traumatic noise. Here, we focus on the role of adenosine receptors (AR) in the development of noise-induced neural injury in the cochlea using A1AR and A2AAR null mice (A1AR(-/-) and A2AAR(-/-)). Wildtype (WT) and AR deficient mice were exposed to octave band noise (8-16 kHz, 100 dB SPL) for 2 hours to induce cochlear injury and hearing loss...
December 26, 2016: Hearing Research
https://www.readbyqxmd.com/read/28034617/cochlear-hair-cell-regeneration-after-noise-induced-hearing-loss-does-regeneration-follow-development
#14
REVIEW
Fei Zheng, Jian Zuo
Noise-induced hearing loss (NIHL) affects a large number of military personnel and civilians. Regenerating inner-ear cochlear hair cells (HCs) is a promising strategy to restore hearing after NIHL. In this review, we first summarize recent transcriptome profile analysis of zebrafish lateral lines and chick utricles where spontaneous HC regeneration occurs after HC damage. We then discuss recent studies in other mammalian regenerative systems such as pancreas, heart and central nervous system. Both spontaneous and forced HC regeneration occurs in mammalian cochleae in vivo involving proliferation and direct lineage conversion...
December 26, 2016: Hearing Research
https://www.readbyqxmd.com/read/28027920/examining-the-short-term-effects-of-emotion-under-an-adaptation-level-theory-model-of-tinnitus-perception
#15
Mithila Durai, Mary G O'Keeffe, Grant D Searchfield
OBJECTIVES: Existing evidence suggests a strong relationship between tinnitus and emotion. The objective of this study was to examine the effects of short-term emotional changes along valence and arousal dimensions on tinnitus outcomes. Emotional stimuli were presented in two different modalities: auditory and visual. The authors hypothesized that (1) negative valence (unpleasant) stimuli and/or high arousal stimuli will lead to greater tinnitus loudness and annoyance than positive valence and/or low arousal stimuli, and (2) auditory emotional stimuli, which are in the same modality as the tinnitus, will exhibit a greater effect on tinnitus outcome measures than visual stimuli...
December 24, 2016: Hearing Research
https://www.readbyqxmd.com/read/28011084/multiscale-mapping-of-frequency-sweep-rate-in-mouse-auditory-cortex
#16
John B Issa, Benjamin D Haeffele, Eric D Young, David T Yue
Functional organization is a key feature of the neocortex that often guides studies of sensory processing, development, and plasticity. Tonotopy, which arises from the transduction properties of the cochlea, is the most widely studied organizational feature in auditory cortex; however, in order to process complex sounds, cortical regions are likely specialized for higher order features. Here, motivated by the prevalence of frequency modulations in mouse ultrasonic vocalizations and aided by the use of a multiscale imaging approach, we uncover a functional organization across the extent of auditory cortex for the rate of frequency modulated (FM) sweeps...
December 21, 2016: Hearing Research
https://www.readbyqxmd.com/read/28011083/impaired-auditory-processing-and-altered-structure-of-the-endbulb-of-held-synapse-in-mice-lacking-the-glua3-subunit-of-ampa-receptors
#17
Sofía García-Hernández, Manabu Abe, Kenji Sakimura, María E Rubio
AMPA glutamate receptor complexes with fast kinetics conferred by subunits like GluA3 and GluA4 are essential for temporal precision of synaptic transmission. The specific role of GluA3 in auditory processing and experience related changes in the auditory brainstem remain unknown. We investigated the role of the GluA3 in auditory processing by using wild type (WT) and GluA3 knockout (GluA3-KO) mice. We recorded auditory brainstem responses (ABR) to assess auditory function and used electron microscopy to evaluate the ultrastructure of the auditory nerve synapse on bushy cells (AN-BC synapse)...
December 21, 2016: Hearing Research
https://www.readbyqxmd.com/read/28007526/noise-induced-cochlear-synaptopathy-past-findings-and-future-studies
#18
REVIEW
Megan Kobel, Colleen G Le Prell, Jennifer Liu, John W Hawks, Jianxin Bao
For decades, we have presumed the death of hair cells and spiral ganglion neurons are the main cause of hearing loss and difficulties understanding speech in noise, but new findings suggest synapse loss may be the key contributor. Specifically, recent preclinical studies suggest that the synapses between inner hair cells and spiral ganglion neurons with low spontaneous rates and high thresholds are the most vulnerable subcellular structures, with respect to insults during aging and noise exposure. This cochlear synaptopathy can be "hidden" because this synaptic loss can occur without permanent hearing threshold shifts...
December 19, 2016: Hearing Research
https://www.readbyqxmd.com/read/28007525/the-mammalian-cretaceous-cochlear-revolution
#19
REVIEW
Geoffrey A Manley
The hearing organs of amniote vertebrates show large differences in their size and structure between the species' groups. In spite of this, their performance in terms of hearing sensitivity and the frequency selectivity of auditory-nerve units shows unexpectedly small differences. The only substantial difference is that therian, defined as live-bearing, mammalian groups are able to hear ultrasonic frequencies (above 15-20 kHz), whereas in contrast monotreme (egg laying) mammals and all non-mammalian amniotes cannot...
December 19, 2016: Hearing Research
https://www.readbyqxmd.com/read/28003148/evidence-of-hidden-hearing-loss-following-noise-exposures-that-produce-robust-tts-and-abr-wave-i-amplitude-reductions
#20
Edward Lobarinas, Christopher Spankovich, Colleen G Le Prell
In animals, noise exposures that produce robust temporary threshold shifts (TTS) can produce immediate damage to afferent synapses and long-term degeneration of low spontaneous rate auditory nerve fibers. This synaptopathic damage has been shown to correlate with reduced auditory brainstem response (ABR) wave-I amplitudes at suprathreshold levels. The perceptual consequences of this "synaptopathy" remain unknown but have been suggested to include compromised hearing performance in competing background noise...
December 19, 2016: Hearing Research
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