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Hearing Research

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https://www.readbyqxmd.com/read/29778289/diseases-and-targets-for-local-drug-delivery-to-the-inner-ear
#1
Lawrence R Lustig
No abstract text is available yet for this article.
May 11, 2018: Hearing Research
https://www.readbyqxmd.com/read/29776691/a-voice-patch-system-in-the-primate-brain-for-processing-vocal-information
#2
Pascal Belin, Clémentine Bodin, Virginia Aglieri
We review behavioural and neural evidence for the processing of information contained in conspecific vocalizations (CVs) in three primate species: humans, macaques and marmosets. We focus on abilities that are present and ecologically relevant in all three species: the detection and sensitivity to CVs; and the processing of identity cues in CVs. Current evidence, although fragmentary, supports the notion of a "voice patch system" in the primate brain analogous to the face patch system of visual cortex: a series of discrete, interconnected cortical areas supporting increasingly abstract representations of the vocal input...
May 7, 2018: Hearing Research
https://www.readbyqxmd.com/read/29779607/impact-of-snr-masker-type-and-noise-reduction-processing-on-sentence-recognition-performance-and-listening-effort-as-indicated-by-the-pupil-dilation-response
#3
Barbara Ohlenforst, Dorothea Wendt, Sophia E Kramer, Graham Naylor, Adriana A Zekveld, Thomas Lunner
Recent studies have shown that activating the noise reduction scheme in hearing aids results in a smaller peak pupil dilation (PPD), indicating reduced listening effort, at 50% and 95% correct sentence recognition with a 4-talker masker. The objective of this study was to measure the effect of the noise reduction scheme (on or off) on PPD and sentence recognition across a wide range of signal-to-noise ratios (SNRs) from +16 dB to -12 dB and two masker types (4-talker and stationary noise). Relatively low PPDs were observed at very low (-12 dB) and very high (+16 dB to +8 dB) SNRs presumably due to 'giving up' and 'easy listening', respectively...
May 6, 2018: Hearing Research
https://www.readbyqxmd.com/read/29759684/how-aging-impacts-the-encoding-of-binaural-cues-and-the-perception-of-auditory-space
#4
REVIEW
Ann Clock Eddins, Erol J Ozmeral, David A Eddins
Over the years, the effect of aging on auditory function has been investigated in animal models and humans in an effort to characterize age-related changes in both perception and physiology. Here, we review how aging may impact neural encoding and processing of binaural and spatial cues in human listeners with a focus on recent work by the authors as well as others. Age-related declines in monaural temporal processing, as estimated from measures of gap detection and temporal fine structure discrimination, have been associated with poorer performance on binaural tasks that require precise temporal processing...
May 5, 2018: Hearing Research
https://www.readbyqxmd.com/read/29754876/bone-morphogenetic-protein-4-antagonizes-hair-cell-regeneration-in-the-avian-auditory-epithelium
#5
Rebecca M Lewis, Jesse J Keller, Liangcai Wan, Jennifer S Stone
Permanent hearing loss is often a result of damage to cochlear hair cells, which mammals are unable to regenerate. Non-mammalian vertebrates such as birds replace damaged hair cells and restore hearing function, but mechanisms controlling regeneration are not understood. The secreted protein bone morphogenetic protein 4 (BMP4) regulates inner ear morphogenesis and hair cell development. To investigate mechanisms controlling hair cell regeneration in birds, we examined expression and function of BMP4 in the auditory epithelia (basilar papillae) of chickens of either sex after hair cell destruction by ototoxic antibiotics...
May 2, 2018: Hearing Research
https://www.readbyqxmd.com/read/29773471/increased-spontaneous-firing-rates-in-auditory-midbrain-following-noise-exposure-are-specifically-abolished-by-a-kv3-channel-modulator
#6
Lucy A Anderson, Lara L Hesse, Nadia Pilati, Warren M H Bakay, Giuseppe Alvaro, Charles H Large, David McAlpine, Roland Schaette, Jennifer F Linden
Noise exposure has been shown to produce long-lasting increases in spontaneous activity in central auditory structures in animal models, and similar pathologies are thought to contribute to clinical phenomena such as hyperacusis or tinnitus in humans. Here we demonstrate that multi-unit spontaneous neuronal activity in the inferior colliculus (IC) of mice is significantly elevated four weeks following noise exposure at recording sites with frequency tuning within or near the noise exposure band, and this selective central auditory pathology can be normalised through administration of a novel compound that modulates activity of Kv3 voltage-gated ion channels...
April 30, 2018: Hearing Research
https://www.readbyqxmd.com/read/29778290/spatial-hearing-ability-of-the-pigmented-guinea-pig-cavia-porcellus-minimum-audible-angle-and-spatial-release-from-masking-in-azimuth
#7
Nathaniel T Greene, Kelsey L Anbuhl, Alexander T Ferber, Marisa DeGuzman, Paul D Allen, Daniel J Tollin
Despite the common use of guinea pigs in investigations of the neural mechanisms of binaural and spatial hearing, their behavioral capabilities in spatial hearing tasks have surprisingly not been thoroughly investigated. To begin to fill this void, we tested the spatial hearing of adult male guinea pigs in several experiments using a paradigm based on the prepulse inhibition (PPI) of the acoustic startle response. In the first experiment, we presented continuous broadband noise from one speaker location and switched to a second speaker location (the "prepulse") along the azimuth prior to presenting a brief, ∼110 dB SPL startle-eliciting stimulus...
April 27, 2018: Hearing Research
https://www.readbyqxmd.com/read/29753562/cortical-processing-of-location-changes-in-a-cocktail-party-situation-spatial-oddball-effects-on-electrophysiological-correlates-of-auditory-selective-attention
#8
Jörg Lewald, Michael-Christian Schlüter, Stephan Getzmann
Neural mechanisms of selectively attending to a sound source of interest in a simulated "cocktail-party" situation, composed of multiple competing sources, were investigated using event-related potentials in combination with a spatial oddball design. Subjects either detected rare spatial deviants in a series of standard sounds or passively listened. Targets either appeared in isolation or in the presence of two distractor sound sources at different locations ("cocktail-party" condition)...
April 27, 2018: Hearing Research
https://www.readbyqxmd.com/read/29703651/sound-localization-performance-of-patients-with-single-sided-deafness-is-not-improved-when-listening-with-a-bone-conduction-device
#9
Martijn J H Agterberg, Ad F M Snik, Rens M G Van de Goor, Myrthe K S Hol, A John Van Opstal
An increased number of treatment options has become available for patients with single sided deafness (SSD), who are seeking hearing rehabilitation. For example, bone-conduction devices that employ contralateral routing of sound (CROS), by transmitting acoustic bone vibrations from the deaf side to the cochlea of the hearing ear, are widely used. However, in some countries, cochlear implantation is becoming the standard treatment. The present study investigated whether CROS intervention, by means of a CROS bone-conduction device (C-BCD), affected sound-localization performance of patients with SSD...
April 19, 2018: Hearing Research
https://www.readbyqxmd.com/read/29706463/characterizing-a-novel-vglut3-p2a-icreer-knockin-mouse-strain-in-cochlea
#10
Chao Li, Yilai Shu, Guangqin Wang, He Zhang, Ying Lu, Xiang Li, Gen Li, Lei Song, Zhiyong Liu
Precise mouse genetic studies rely on specific tools that can label specific cell types. In mouse cochlea, previous studies suggest that vesicular glutamate transporter 3 (vGlut3), also known as Slc17a8, is specifically expressed in inner hair cells (IHCs) and loss of vGlut3 causes deafness. To take advantage of its unique expression pattern, here we generate a novel vGlut3-P2A-iCreER knockin mouse strain. The P2A-iCreER cassette is precisely inserted before stop codon of vGlut3, by which the endogenous vGlut3 is intact and paired with iCreER as well...
April 17, 2018: Hearing Research
https://www.readbyqxmd.com/read/29692331/towards-an-objective-test-of-chronic-tinnitus-properties-of-auditory-cortical-potentials-evoked-by-silent-gaps-in-tinnitus-like-sounds
#11
Brandon T Paul, Marc Schoenwiesner, Sylvie Hébert
A common method designed to identify if an animal hears tinnitus assumes that tinnitus "fills-in" silent gaps in background sound. This phenomenon has not been reliably demonstrated in humans. One test of the gap-filling hypothesis would be to determine if gap-evoked cortical potentials are absent or attenuated when measured within background sound matched to the tinnitus sensation. However the tinnitus sensation is usually of low intensity and of high frequency, and it is unknown if cortical responses can be measured with such "weak" stimulus properties...
April 17, 2018: Hearing Research
https://www.readbyqxmd.com/read/29729903/restoration-of-spatial-hearing-in-adult-cochlear-implant-users-with-single-sided-deafness
#12
Ruth Y Litovsky, Keng Moua, Shelly Godar, Alan Kan, Sara M Misurelli, Daniel J Lee
In recent years, cochlear implants (CIs) have been provided in growing numbers to people with not only bilateral deafness but also to people with unilateral hearing loss, at times in order to alleviate tinnitus. This study presents audiological data from 15 adult participants (ages 48 ± 12 years) with single sided deafness. Results are presented from 9/15 adults, who received a CI (SSD-CI) in the deaf ear and were tested in Acoustic or Acoustic + CI hearing modes, and 6/15 adults who are planning to receive a CI, and were tested in the unilateral condition only...
April 14, 2018: Hearing Research
https://www.readbyqxmd.com/read/29673567/electric-acoustic-forward-masking-in-cochlear-implant-users-with-ipsilateral-residual-hearing
#13
Marina Imsiecke, Benjamin Krüger, Andreas Büchner, Thomas Lenarz, Waldo Nogueira
In order to investigate the temporal mechanisms of the auditory system, psychophysical forward masking experiments were conducted in cochlear implant users who had preserved acoustic hearing in the ipsilateral ear. This unique electric-acoustic stimulation (EAS) population allowed the measurement of threshold recovery functions for acoustic or electric probes in the presence of electric or acoustic maskers, respectively. In the electric masking experiment, the forward masked threshold elevation of acoustic probes was measured as a function of the time interval after the offset of the electric masker, i...
April 9, 2018: Hearing Research
https://www.readbyqxmd.com/read/29661613/functions-of-cabp1-and-cabp2-in-the-peripheral-auditory-system
#14
Tian Yang, Ning Hu, Tina Pangršič, Steven Green, Marlan Hansen, Amy Lee
CaBPs are a family of Ca2+ binding proteins related to calmodulin. Two CaBP family members, CaBP1 and CaBP2, are highly expressed in the cochlea. Here, we investigated the significance of CaBP1 and CaBP2 for hearing in mice lacking expression of these proteins (CaBP1 KO and CaBP2 KO) using auditory brain responses (ABRs) and distortion product otoacoustic emissions (DPOAEs). In CaBP1 KO mice, ABR wave I was larger in amplitude, and shorter in latency and faster in decay, suggestive of enhanced synchrony of auditory nerve fibers...
April 9, 2018: Hearing Research
https://www.readbyqxmd.com/read/29685616/supra-threshold-auditory-brainstem-response-amplitudes-in-humans-test-retest-reliability-electrode-montage-and-noise-exposure
#15
Garreth Prendergast, Wenhe Tu, Hannah Guest, Rebecca E Millman, Karolina Kluk, Samuel Couth, Kevin J Munro, Christopher J Plack
The auditory brainstem response (ABR) is a sub-cortical evoked potential in which a series of well-defined waves occur in the first 10 ms after the onset of an auditory stimulus. Wave V of the ABR, particularly wave V latency, has been shown to be remarkably stable over time in individual listeners. However, little attention has been paid to the reliability of wave I, which reflects auditory nerve activity. This ABR component has attracted interest recently, as wave I amplitude has been identified as a possible non-invasive measure of noise-induced cochlear synaptopathy...
April 6, 2018: Hearing Research
https://www.readbyqxmd.com/read/29678326/the-effects-of-the-activation-of-the-inner-hair-cell-basolateral-k-channels-on-auditory-nerve-responses
#16
Alessandro Altoè, Ville Pulkki, Sarah Verhulst
The basolateral membrane of the mammalian inner hair cell (IHC) expresses large voltage and Ca2+ gated outward K+ currents. To quantify how the voltage-dependent activation of the K+ channels affects the functionality of the auditory nerve innervating the IHC, this study adopts a model of mechanical-to-neural transduction in which the basolateral K+ conductances of the IHC can be made voltage-dependent or not. The model shows that the voltage-dependent activation of the K+ channels (i) enhances the phase-locking properties of the auditory fiber (AF) responses; (ii) enables the auditory nerve to encode a large dynamic range of sound levels; (iii) enables the AF responses to synchronize precisely with the envelope of amplitude modulated stimuli; and (iv), is responsible for the steep offset responses of the AFs...
April 6, 2018: Hearing Research
https://www.readbyqxmd.com/read/29661614/a-fluorescence-based-imaging-approach-to-pharmacokinetic-analysis-of-intracochlear-drug-delivery
#17
Andrew M Ayoob, Marcello Peppi, Vishal Tandon, Robert Langer, Jeffrey T Borenstein
Advances in microelectromechanical systems (MEMS) technologies are enhancing the development of intracochlear delivery devices for the treatment of hearing loss with emerging pharmacological therapies. Direct intracochlear delivery addresses the limitations of systemic and intratympanic delivery. However, optimization of delivery parameters for these devices requires pharmacokinetic assessment of the spatiotemporal drug distribution inside the cochlea. Robust methods of measuring drug concentration in the perilymph have been developed, but lack spatial resolution along the tonotopic axis or require complex physiological measurements...
April 5, 2018: Hearing Research
https://www.readbyqxmd.com/read/29678325/does-hearing-in-response-to-soft-tissue-stimulation-involve-skull-vibrations-a-within-subject-comparison-between-skull-vibration-magnitudes-and-hearing-thresholds
#18
Shai Chordekar, Ronen Perez, Cahtia Adelman, Haim Sohmer, Liat Kishon-Rabin
Hearing can be elicited in response to bone as well as soft-tissue stimulation. However, the underlying mechanism of soft-tissue stimulation is under debate. It has been hypothesized that if skull vibrations were the underlying mechanism of hearing in response to soft-tissue stimulation, then skull vibrations would be associated with hearing thresholds. However, if skull vibrations were not associated with hearing thresholds, an alternative mechanism is involved. In the present study, both skull vibrations and hearing thresholds were assessed in the same participants in response to bone (mastoid) and soft-tissue (neck) stimulation...
April 3, 2018: Hearing Research
https://www.readbyqxmd.com/read/29655975/vestibular-and-balance-function-is-often-impaired-in-children-with-profound-unilateral-sensorineural-hearing-loss
#19
Meirav Sokolov, Karen A Gordon, Melissa Polonenko, Susan I Blaser, Blake C Papsin, Sharon L Cushing
RATIONALE: Children with unilateral deafness could have concurrent vestibular dysfunction which would be associated with balance deficits and potentially impair overall development. The prevalence of vestibular and balance deficits remains to be defined in these children. METHODS: Twenty children with unilateral deafness underwent comprehensive vestibular and balance evaluation. RESULTS: Retrospective review revealed that more than half of the cohort demonstrated some abnormality of the vestibular end organs (otoliths and horizontal canal), with the prevalence of end organ specific dysfunction ranging from 17 to 48% depending on organ tested and method used...
April 3, 2018: Hearing Research
https://www.readbyqxmd.com/read/29653842/hearing-loss-in-older-adults-from-epidemiological-insights-to-national-initiatives
#20
Adele M Goman, Frank R Lin
The broader implications of hearing loss for the health and functioning of older adults have begun to be demonstrated in epidemiologic studies. These research findings on the association between hearing loss and poorer health outcomes have formed the foundation for national initiatives on hearing loss and public health. These national initiatives range from the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) clinical trial to the recent passage of the bipartisan Over-The-Counter Hearing Aid Act. Utilizing population health research methodologies to study hearing loss can provide the foundation for initiating top-down approaches to increase the adoption and accessibility of hearing care for older Americans with hearing loss...
April 3, 2018: Hearing Research
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