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Hearing Research

Teresa Ribas-Prats, Laura Almeida, Jordi Costa-Faidella, Montse Plana, M J Corral, M Dolores Gómez-Roig, Carles Escera
The Frequency-Following Response (FFR) is a neurophonic auditory evoked potential that reflects the efficient encoding of speech sounds and is disrupted in a range of speech and language disorders. This raises the possibility to use it as a potential biomarker for literacy impairment. However, reference values for comparison with the normal population are not yet established. The present study pursues the collection of a normative database depicting the standard variability of the newborn FFR. FFRs were recorded to /da/ and /ga/ syllables in 46 neonates born at term...
November 9, 2018: Hearing Research
Ning Zhou, Juliana Mathews, Lixue Dong
Cochlear implant (CI) users do not reliably associate an increase in pulse rate above 300 pulses per second (pps) with an increase in pitch. The locus of this upper limit of pitch remains unknown. The present study tested the hypothesis that this deficit resides at least initially at the auditory nerve. The hypothesis was tested by comparing pulse rate discrimination in different neural excitation patterns, in which a large versus small population of auditory nerve fibers was activated. If poorer pulse rate discrimination was found under conditions where narrower spread of neural excitation (SOE) was anticipated where a relatively small neural population was activated, then it would support the hypothesis that the rate processing deficit found in CI users is related to peripheral neural degeneration...
November 3, 2018: Hearing Research
Sara Magits, Arturo Moncada-Torres, Lieselot Van Deun, Jan Wouters, Astrid van Wieringen, Tom Francart
The understanding of speech in noise relies (at least partially) on spectrotemporal modulation sensitivity. This sensitivity can be measured by spectral ripple tests, which can be administered at different presentation levels. However, it is not known how presentation level affects spectrotemporal modulation thresholds. In this work, we present behavioral data for normal-hearing adults which show that at higher ripple densities (2 and 4 ripples/oct), increasing presentation level led to worse discrimination thresholds...
November 2, 2018: Hearing Research
J Seebacher, A Franke-Trieger, V Weichbold, P Zorowka, K Stephan
The main impairment associated with single-sided deafness (SSD) is the loss of binaural hearing. Currently, the most effective treatment to compensate for this deficit is to supply patients suffering from SSD with a cochlear implant (CI) in the deaf ear. With this approach binaural hearing abilities can be restored to a certain extent, which is expressed in an improvement in such patients with regard to sound source localization and speech comprehension in noise after receipt of a CI. However, binaural performance of these listeners does not reach the level of normal-hearing listeners...
October 29, 2018: Hearing Research
Douglas H Keefe, M Patrick Feeney, Lisa L Hunter, Denis F Fitzpatrick, Chelsea M Blankenship, Angela C Garinis, Daniel B Putterman, Marcin Wróblewski
Transient-evoked otoacoustic emissions (TEOAEs) at high frequencies are a non-invasive physiological test of basilar membrane mechanics at the basal end, and have clinical potential to detect risk of hearing loss related to outer-hair-cell dysfunction. Using stimuli with constant incident pressure across frequency, TEOAEs were measured in experiment 1 at low frequencies (0.7-8 kHz) and high frequencies (7.1-14.7 kHz) in adults with normal hearing up to 8 kHz and varying hearing levels from 9 to 16 kHz...
October 18, 2018: Hearing Research
Brett R Schofield, Nichole L Beebe
The inferior colliculus occupies a central position in ascending and descending auditory pathways. A substantial proportion of its neurons are GABAergic, and these neurons contribute to intracollicular circuits as well as to extrinsic projections to numerous targets. A variety of types of evidence - morphology, physiology, molecular markers - indicate that the GABAergic cells can be divided into at least four subtypes that serve different functions. However, there has yet to emerge a unified scheme for distinguishing these subtypes...
October 4, 2018: Hearing Research
Elad Sagi, Mario A Svirsky
A potential bottleneck to improving speech perception performance in cochlear implant (CI) users is that some of their electrodes may poorly encode speech information. Several studies have examined the effect of deactivating poorly encoding electrodes on speech perception with mixed results. Many of these studies focused on identifying poorly encoding electrodes by some measure (e.g. electrode discrimination, pitch ordering, threshold, CT-guided, masked modulation detection), but provide inconsistent criteria about which electrodes, and how many, should be deactivated, and without considering how speech information becomes distributed across the electrode array...
December 2018: Hearing Research
Jeong-Seo Kim, Viral D Tejani, Paul J Abbas, Carolyn J Brown
OBJECTIVE: Shorter electrode arrays and soft surgical techniques allow for preservation of acoustic hearing in many cochlear implant (CI) users. Recently, we developed a method of using the Neural Response Telemetry (NRT) system built in Custom Sound EP clinical software to record acoustically evoked electrocochleography (ECoG) responses from an intracochlear electrode in Nucleus Hybrid CI users (Abbas et al., 2017). We recorded responses dominated by the hair cells (cochlear microphonic, CM/DIF) and the auditory nerve (auditory nerve neurophonic, ANN/SUM)...
December 2018: Hearing Research
Yasmin Soares de Lima, Marcela Chiabai, Jun Shen, Mara S Córdoba, Beatriz R Versiani, Rosenelle O A Benício, Robert Pogue, Regina Célia Mingroni-Netto, Karina Lezirovitz, Aline Pic-Taylor, Juliana F Mazzeu, Silviene F Oliveira
Syndromic hearing loss accounts for approximately 30% of all cases of hearing loss due to genetic causes. Mutation screening in known genes is important because it potentially sheds light on the genetic etiology of hearing loss and helps in genetic counseling of families. In this study, we describe a customized Ion AmpliSeq Panel, specifically designed for the investigation of syndromic hearing loss. The Ion AmpliSeq Panel was customized to cover the coding sequences of 52 genes. Twenty-four patients were recruited: 17 patients with a clinical diagnosis of a known syndrome, and seven whose clinical signs did not allow identification of a syndrome...
December 2018: Hearing Research
Maarten F B van Beurden, Wouter A Dreschler
This study examines temporal effects both at threshold and at supra-threshold levels. The level needed to detect a short-duration 4.0-kHz signal was measured for signals presented with different onset delays relative to a 300-ms broadband noise masker: 100 ms and 5 ms before the onset of the masker and 5 ms and 100 ms after the onset of the masker. Loudness matches between the signal in quiet and the signal at the same four onset delays were obtained for five presentation levels of the short-duration signal and for three masker levels...
December 2018: Hearing Research
I-Hui Hsieh, Jia-Wei Liu, Zeng-Jie Liang
Binaural integration of interaural temporal information is essential for sound source localization and segregation. Current models of binaural interaction have shown that accurate sound localization in the horizontal plane depends on the resolution of phase ambiguous information by across-frequency integration. However, as such models are mostly static, it is not clear how proximate in time binaural events in different frequency channels should occur to form an auditory object with a unique lateral position...
December 2018: Hearing Research
Junfeng Liang, Kyle D Smith, Hongbing Lu, Thomas W Seale, Rong Z Gan
Mechanical properties of the tympanic membrane (TM) are important for studying the transfer function of the auditory system. However, nearly all reported human data are limited to adults because of the unavailability of temporal bones from children. In this study, we used the baboon (Papio anubis), a genetically close human relative, as a model to address the occurrence of age-dependent changes of the human TM. Forty-five baboon TMs were characterized in five age groups: <1 year, 1 to <2 years, 2 to <3 years, 3 to <5, and >5 years of age, comparable to human ages ranging from newborn to adult...
December 2018: Hearing Research
Tess K Koerner, Yang Zhang
Understanding speech in background noise is difficult for many listeners with and without hearing impairment (HI). This study investigated the effects of HI on speech discrimination and recognition measures as well as speech-evoked cortical N1-P2 and MMN auditory event-related potentials (AERPs) in background noise. We aimed to determine which AERP components can predict the effects of HI on speech perception in noise across adult listeners with and without HI. The data were collected from 18 participants with hearing thresholds ranging from within normal limits to bilateral moderate-to-severe sensorineural hearing loss...
December 2018: Hearing Research
Sabine Thomassen, Alexandra Bendixen
A listener who focusses on a sound source of interest must continuously integrate the sounds emitted by the attended source and ignore the sounds emitted by the remaining sources in the auditory scene. Little is known about how the ignored sound sources in the background are mentally represented after the source of interest has formed the perceptual foreground. This is due to a key methodological challenge: the background representation is by definition not overtly reportable. Here we developed a paradigm based on event-related brain potentials (ERPs) to assess the mental representation of background sounds...
December 2018: Hearing Research
Naomi F Bramhall, Garnett P McMillan, Sharon G Kujawa, Dawn Konrad-Martin
Cochlear synaptopathy, the loss of synaptic connections between inner hair cells (IHCs) and auditory nerve fibers, has been documented in animal models of aging, noise, and ototoxic drug exposure, three common causes of acquired sensorineural hearing loss in humans. In each of these models, synaptopathy begins prior to changes in threshold sensitivity or loss of hair cells; thus, this underlying injury can be hidden behind a normal threshold audiogram. Since cochlear synaptic loss cannot be directly confirmed in living humans, non-invasive assays will be required for diagnosis...
December 2018: Hearing Research
Daniel John Brown, Ljiljana Sokolic, Albert Fung, Christopher John Pastras
In an attempt to develop an animal model of immune mediated Meniere's disease, we have injected lipopolysaccharide (LPS) directly into scala media of guinea pigs and monitored functional and morphological changes over a period of 6 weeks. Depending on the concentration of LPS, changes ranged from moderate-to-severe hearing loss and endolymphatic hydrops with minimal cellular infiltrate or fibrosis, to dense cellular infiltration that filled the scalae. Interestingly, higher concentrations of LPS not only induced severe cellular infiltration, hydrops, and hearing loss, but also a substantial enlargement of the endolymphatic duct and sac...
December 2018: Hearing Research
Henry E Heffner, Rickye S Heffner
No abstract text is available yet for this article.
December 2018: Hearing Research
Ivo Dobrev, Jae Hoon Sim, Flurin Pfiffner, Alexander M Huber, Christof Röösli
OBJECTIVES: Evaluation of the transfer function efficiency of a newly-developed piezo-electric actuator for active subcutaneous bone conduction hearing aid. METHODS: The experiments were conducted on four Thiel embalmed whole head cadaver specimens. A novel actuator based on piezo-electric transduction (PZTA), part of a subcutaneous bone conduction hearing aid device, was sequentially implanted on three locations: 1) Immediately posterior to pinna; 2) 50-60 mm posterior to pinna, approximately the same distance as between the BAHA (bone anchored hearing aid) location and the ear canal, but the same horizontal level as location 1; 3) the traditional BAHA location...
December 2018: Hearing Research
Alberto Recio-Spinoso, John S Oghalai
One of the tenets of mammalian auditory physiology is that the frequency selectivity at the cochlear base decreases as a function of stimulus level. Changes in frequency selectivity have been shown to be accompanied by changes in response phases as a function of stimulus level. The existence of such nonlinear properties has been revealed by the analysis of either direct or indirect recordings of mechanical vibrations of the cochlea. Direct measurements of cochlear mechanical vibrations, however, have been carried out with success primarily in cochlear regions that are tuned to frequencies >7 kHz, but not in regions sensitive to lower frequencies...
December 2018: Hearing Research
Darren Mao, Hamish Innes-Brown, Matthew A Petoe, Yan T Wong, Colette M McKay
Cortical auditory evoked potential (CAEP) thresholds have been shown to correlate well with behaviourally determined hearing thresholds. Growth functions of CAEPs show promise as an alternative to single level detection for objective hearing threshold estimation; however, the accuracy and clinical relevance of this method is not well examined. In this study, we used temporal and spectral CAEP features to generate feature growth functions. Spectral features may be more robust than traditional peak-picking methods where CAEP morphology is variable, such as in children or hearing device users...
December 2018: Hearing Research
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