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Alan W Barclay
No abstract text is available yet for this article.
October 5, 2016: Maturitas
Amy S Gottlieb
No abstract text is available yet for this article.
September 21, 2016: Maturitas
Richard Hoffman
No abstract text is available yet for this article.
September 13, 2016: Maturitas
G Michael Allan, James P McCormack, Christina Korownyk, Adrienne J Lindblad, Scott Garrison, Michael R Kolber
No abstract text is available yet for this article.
August 28, 2016: Maturitas
Todd Rosen, Gloria Bachmann
No abstract text is available yet for this article.
August 24, 2016: Maturitas
Herjan J T Coelingh Bennink, Carole Verhoeven, Yvette Zimmerman, Monique Visser, Jean-Michel Foidart, Kristina Gemzell-Danielsson
No abstract text is available yet for this article.
August 24, 2016: Maturitas
Jose Lara, Michael J Sherratt, Margaret Rees
No abstract text is available yet for this article.
November 2016: Maturitas
Kathleen Mikkelsen, Lily Stojanovska, Kathy Tangalakis, Marijan Bosevski, Vasso Apostolopoulos
Cognitive decline is one of the major causes of disability in older people. A high level of homocysteine, a byproduct of vitamin B, has been linked to brain atrophy, which itself is a precursor to cognitive decline leading to dementia and Alzheimer's disease. In addition, a low level of vitamin B is often noted in patients with dementia and Alzheimer's disease and its supplementation has been shown to improve memory and to slow the progress of brain atrophy. This information may aid in the use of vitamin B as a preventative measure against severe cognitive decline, and thus reduce the onset of conditions such as dementia and Alzheimer's disease...
November 2016: Maturitas
Elnur Babayev, Tianren Wang, Klara Szigeti-Buck, Katie Lowther, Hugh S Taylor, Tamas Horvath, Emre Seli
Mitochondria affect numerous aspects of mammalian reproduction. We investigated whether the decrease in oocyte quality associated with aging is related to altered mitochondria. Oocytes from old (12 months) and young (9 weeks) C57BL/6J mice were compared in relation to: mitochondria morphology and dynamics (mitochondria density, coverage, size and shape) throughout folliculogenesis; levels of mitochondrial DNA (mtDNA); mitochondrial stress reflected in the expression of mitochondrial unfolded protein response (mt-UPR) genes; and levels of reactive oxygen species (ROS) under baseline conditions and following H2O2 treatment...
November 2016: Maturitas
Catherine Lucas, Julie Byles, Jennifer H Martin
There are a number of complex and seemingly ignored issues around prescribing safely and effectively for older people, particularly for very old women. These issues include polypharmacy, possible compliance issues and communication barriers between patient, specialists and general practitioners (GPs). There are specific pharmacokinetic (PK) and pharmacodynamic (PD) parameters that change in older age generally, and in women more specifically, which if ignored are likely to cause symptoms and to impair quality of life when drug dosage is unchanged...
November 2016: Maturitas
Myra S Hunter, Claire Hardy, Sam Norton, Amanda Griffiths
BACKGROUND: Hot flushes and night sweats (HFNS) - the main symptoms of the menopause transition - can reduce quality of life and are particularly difficult to manage at work. A cognitive behaviour therapy (CBT) intervention has been developed specifically for HFNS that is theoretically based and shown to reduce significantly the impact of HFNS in several randomised controlled trials (RCTs). Self-help CBT has been found to be as effective as group CBT for these symptoms, but these interventions are not widely available in the workplace...
October 2016: Maturitas
Gita D Mishra, Hsin-Fang Chung, Nirmala Pandeya, Annette J Dobson, Lee Jones, Nancy E Avis, Sybil L Crawford, Ellen B Gold, Daniel Brown, Lynette L Sievert, Eric Brunner, Janet E Cade, Victoria J Burley, Darren C Greenwood, Graham G Giles, Fiona Bruinsma, Alissa Goodman, Kunihiko Hayashi, Jung Su Lee, Hideki Mizunuma, Diana Kuh, Rachel Cooper, Rebecca Hardy, Carla Makhlouf Obermeyer, Kathryn A Lee, Mette Kildevæld Simonsen, Toyoko Yoshizawa, Nancy F Woods, Ellen S Mitchell, Mark Hamer, Panayotes Demakakos, Sven Sandin, Hans-Olov Adami, Elisabete Weiderpass, Debra Anderson
OBJECTIVES: The International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE) project is a global research collaboration that aims to advance understanding of women's reproductive health in relation to chronic disease risk by pooling individual participant data from several cohort and cross-sectional studies. The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE...
October 2016: Maturitas
Matthew Lee Smith, Heather Honoré Goltz, Audry S Motlagh, SangNam Ahn, Caroline D Bergeron, Marcia G Ory
PURPOSE: This study aims to identify socio-demographic and health behavior factors associated with cardiovascular disease (CVD) diagnosis and patient-physician communication concerning sexual issues among older Veterans. METHODS: Cross-sectional data were collected from 635 male Veterans over age 55 years as part of the 2010 National Social Life, Health and Aging Project, a nationally-representative, population-based study of community-dwelling older Americans. Two independent logistic regression analyses were performed...
October 2016: Maturitas
E Gregorio-Arenas, P Ruiz-Cabello, D Camiletti-Moirón, N Moratalla-Cecilia, P Aranda, M López-Jurado, J Llopis, V A Aparicio
OBJECTIVE: To study the association between physical fitness and body-size phenotypes, and to test which aspects of physical fitness show the greatest independent association with cardiometabolic risk in perimenopausal women. STUDY DESIGN: This cross-sectional study involved 228 women aged 53±5years from southern Spain. MAIN OUTCOME MEASUREMENTS: Physical fitness was assessed by means of the Senior Fitness Test Battery (additionally including handgrip strength and timed up-and-go tests)...
October 2016: Maturitas
Cemal Ozemek, Kerry L Hildreth, Daniel W Groves, Kerrie L Moreau
OBJECTIVES: We tested the hypothesis that oxidative stress contributes to reductions in left ventricular diastolic (LV) function in estrogen-deficient postmenopausal women, related in part to reduced nitric oxide (NO) bioavailability. STUDY DESIGN: LV diastolic function - recorded using transthoracic echocardiography and determined as the peak early (E) to late (A) mitral inflow velocity ratio and the E to peak early (e') mitral annular velocity ratio - and brachial artery flow mediated dilation (FMD), a biomarker of NO bioavailability, were measured during acute systemic infusions of saline (control) and ascorbic acid (experimental model to decrease oxidative stress) in healthy premenopausal women (N=14, 18-40 years) and postmenopausal women (N=23, 45-75 years)...
October 2016: Maturitas
Meagan Brennan, Nehmat Houssami
Mammographic screening programs were established around the world following randomised clinical trials showing that women who were screened had a significant reduction in the risk of dying from breast cancer. Now, decades later, several harms of screening have become apparent and the degree of risk reduction is being debated. This article aims to provide clinicians with evidence-based information about the benefits and harms of screening mammography to enable them to confidently discuss the issues with their patients...
October 2016: Maturitas
Stavroula Α Paschou, Andromachi Vryonidou, Dimitrios G Goulis
Pituitary incidentalomas are lesions which are detected incidentally in the pituitary gland during imaging procedures for unrelated causes, such as headache, trauma or symptoms involving the neck or central nervous system. The wide application of sensitive brain imaging techniques (CT, MRI) has led to an increasing recognition of such lesions. Although the etiology of pituitary incidentalomas covers a wide range of pathologies, most of them (∼90%) are benign adenomas; nonetheless, they may result in visual and/or neurologic abnormalities...
October 2016: Maturitas
Suraj Dhungana, James E Carlson, Wimal Pathmasiri, Susan McRitchie, Matt Davis, Susan Sumner, Susan E Appt
OBJECTIVE: The objective of this investigation was to determine differences in the profiles of endogenous metabolites (metabolomics) among ovaries and serum derived from Old World nonhuman primates fed prudent or Western diets. DESIGN: A retrospective, observational study was done using archived ovarian tissue and serum from midlife cynomolgus monkeys (Macaca fasicularis). Targeted and broad spectrum metabolomics analysis was used to compare ovarian tissue and serum from monkeys that had been exposed to a prudent diet or a Western diet...
October 2016: Maturitas
Stephen Campbell, Katherine Burn, Cassandra Szoeke
Globally our populations are ageing and with this trend, there is a rise in chronic disease. We know that lifestyle and environment are significant contributors to risk for disease, quality of life and function. Despite this representing an opportunity to improve health and quality of life in ageing, there is a paucity of research in this field. The social aspects of this period of development which have been most researched include employment, function and disability. Grand-parenting is one of the most popular sources of childcare in the world and therefore research investigating this role is of vital significance...
October 2016: Maturitas
Pauline M Maki, Leah H Rubin, Antonia Savarese, Lauren Drogos, Lee P Shulman, Suzanne Banuvar, David R Walega
OBJECTIVES: In a pilot randomized clinical trial of active stellate ganglion blockade (SGB) versus sham control, SGB significantly reduced the frequency of reported moderate to severe vasomotor symptoms (VMS) and the frequency of physiologic VMS measured using ambulatory skin conductance monitors. Here we examine secondary effects of SGB on verbal learning and memory. STUDY DESIGN: In a randomized, sham-controlled study, 36 women met eligibility criteria for cognitive assessments, of whom 17 were randomized to receive fluoroscopy-guided SGB and 19 to sham control...
October 2016: Maturitas
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