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Environment International

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https://www.readbyqxmd.com/read/28527750/estimating-serum-concentrations-of-dioxin-like-compounds-in-the-u-s-population-effective-2005-2006-and-2007-2008-a-multiple-imputation-and-trending-approach-incorporating-nhanes-pooled-sample-data
#1
Anne Bichteler, Daniele S Wikoff, Francis Loko, Mark A Harris
Dioxin-like compounds (DLCs) are monitored in the U.S. population using data collected with the National Health and Nutrition Examination Survey (NHANES). Until recently, participants' serum samples have been analyzed individually, and summary statistics defining reference ranges by age, gender, and race/ethnicity have served as the background by which other biomonitoring data can be evaluated. In the most recent NHANES DLC data, 2005-2006 and 2007-2008, participants' sera have been physically pooled prior to laboratory analysis, introducing major challenges to their utility as a reference population: variability among individuals and relations with covariates are lost, and individual design effects cannot be applied...
May 18, 2017: Environment International
https://www.readbyqxmd.com/read/28525835/emerging-and-legacy-flame-retardants-in-uk-human-milk-and-food-suggest-slow-response-to-restrictions-on-use-of-pbdes-and-hbcdd
#2
Fang Tao, Mohamed Abou-Elwafa Abdallah, Danielle C Ashworth, Philippa Douglas, Mireille B Toledano, Stuart Harrad
The legacy flame retardants (LFRs) polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD), together with six emerging flame retardants (EFRs) were measured in United Kingdom (UK) human milk collected in 2010 (n=25) and 2014-15 (n=10). These data are the first report of the presence of EFRs in UK human milk. The most abundant EFR was β-tetrabromoethylcyclohexane (DBE-DBCH) (average=2.5ng/g lw; geometric mean=1.5ng/g lw), which is comparable to the concentrations of the most abundant LFRs i...
May 16, 2017: Environment International
https://www.readbyqxmd.com/read/28525834/exposure-to-phenols-parabens-and-uv-filters-associations-with-loss-of-function-mutations-in-the-filaggrin-gene-in-men-from-the-general-population
#3
Ulla N Joensen, Niels Jørgensen, Jacob P Thyssen, Jørgen Holm Petersen, Pal B Szecsi, Steen Stender, Anne-Maria Andersson, Niels E Skakkebæk, Hanne Frederiksen
BACKGROUND: Filaggrin is an epidermal protein that is important for normal skin barrier functions. Up to 10% of Europeans and Asians carry filaggrin gene (FLG) loss-of function mutations that appear to facilitate trans-epidermal penetration of certain chemicals. We previously showed that mutation carriers have higher internal exposure to certain phthalates, compared to controls, and hypothesized that they could have increased trans-epidermal penetration of other chemicals. OBJECTIVES: We investigated exposure to non-persistent chemicals in young Danish men with and without FLG mutations...
May 16, 2017: Environment International
https://www.readbyqxmd.com/read/28521193/issues-raised-by-the-reference-doses-for-perfluorooctane-sulfonate-and-perfluorooctanoic-acid
#4
Zhaomin Dong, Md Mezbaul Bahar, Joytishna Jit, Bruce Kennedy, Brian Priestly, Jack Ng, Dane Lamb, Yanju Liu, Luchun Duan, Ravi Naidu
On 25th May 2016, the U.S. EPA released reference doses (RfDs) for Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoic Acid (PFOA) of 20ng/kg/day, which were much more conservative than previous values. These RfDs rely on the choices of animal point of departure (PoD) and the toxicokinetics (TK) model. At this stage, considering that the human evidence is not strong enough for RfD determination, using animal data may be appropriate but with more uncertainties. In this article, the uncertainties concerning RfDs from the choices of PoD and TK models are addressed...
May 15, 2017: Environment International
https://www.readbyqxmd.com/read/28521192/long-term-exposure-to-residential-ambient-fine-and-coarse-particulate-matter-and-incident-hypertension-in-post-menopausal-women
#5
Trenton Honda, Melissa N Eliot, Charles B Eaton, Eric Whitsel, James D Stewart, Lina Mu, Helen Suh, Adam Szpiro, Joel D Kaufman, Sverre Vedal, Gregory A Wellenius
BACKGROUND: Long-term exposure to ambient particulate matter (PM) has been previously linked with higher risk of cardiovascular events. This association may be mediated, at least partly, by increasing the risk of incident hypertension, a key determinant of cardiovascular risk. However, whether long-term exposure to PM is associated with incident hypertension remains unclear. METHODS: Using national geostatistical models incorporating geographic covariates and spatial smoothing, we estimated annual average concentrations of residential fine (PM2...
May 15, 2017: Environment International
https://www.readbyqxmd.com/read/28521191/assessing-human-health-risks-from-pesticide-use-in-conventional-and-innovative-cropping-systems-with-the-browse-model
#6
Sabine-Karen Lammoglia, Marc C Kennedy, Enrique Barriuso, Lionel Alletto, Eric Justes, Nicolas Munier-Jolain, Laure Mamy
BACKGROUND: Reducing the risks and impacts of pesticide use on human health and on the environment is one of the objectives of the European Commission Directive 2009/128/EC in the quest for a sustainable use of pesticides. This Directive, developed through European national plans such as Ecophyto plan in France, promotes the introduction of innovative cropping systems relying, for example, on integrated pest management. Risk assessment for human health of the overall pesticide use in these innovative systems is required before the introduction of those systems to avoid that an innovation becomes a new problem...
May 15, 2017: Environment International
https://www.readbyqxmd.com/read/28501790/obesity-aggravates-toxic-effect-of-bpa-on-spermatogenesis
#7
Weiyue Hu, Tianyu Dong, Lingling Wang, Quanquan Guan, Ling Song, Daozhen Chen, Zuomin Zhou, Minjian Chen, Yankai Xia, Xinru Wang
Both bisphenol A (BPA) and obesity affect male reproductive system. However, whether there is an interaction between them remains poorly understood. The aim of the present study was to evaluate the interaction between BPA exposure and obesity on semen quality and elucidate the mechanism in humans and animals. We firstly analyzed the interaction on semen volume, sperm count per ejaculate, sperm concentration and sperm motility in 357 men, and found that urinary BPA concentration was significantly correlated with sperm count per ejaculate in obese men (β=-34...
May 11, 2017: Environment International
https://www.readbyqxmd.com/read/28500873/evaluation-methods-for-assessing-effectiveness-of-in-situ-remediation-of-soil-and-sediment-contaminated-with-organic-pollutants-and-heavy-metals
#8
REVIEW
Biao Song, Guangming Zeng, Jilai Gong, Jie Liang, Piao Xu, Zhifeng Liu, Yi Zhang, Chen Zhang, Min Cheng, Yang Liu, Shujing Ye, Huan Yi, Xiaoya Ren
Soil and sediment contamination has become a critical issue worldwide due to its great harm to the ecological environment and public health. In recent years, many remediation technologies including physical, chemical, biological, and combined methods have been proposed and adopted for the purpose of solving the problems of soil and sediment contamination. However, current research on evaluation methods for assessing these remediation technologies is scattered and lacks valid and integrated evaluation methods for assessing the remediation effectiveness...
May 10, 2017: Environment International
https://www.readbyqxmd.com/read/28500872/cyp3a-genes-and-the-association-between-prenatal-methylmercury-exposure-and-neurodevelopment
#9
Sabrina Llop, Van Tran, Ferran Ballester, Fabio Barbone, Aikaterini Sofianou-Katsoulis, Jordi Sunyer, Karin Engström, Ayman Alhamdow, Tanzy M Love, Gene E Watson, Mariona Bustamante, Mario Murcia, Carmen Iñiguez, Conrad F Shamlaye, Valentina Rosolen, Marika Mariuz, Milena Horvat, Janja S Tratnik, Darja Mazej, Edwin van Wijngaarden, Philip W Davidson, Gary J Myers, Matthew D Rand, Karin Broberg
BACKGROUND: Results on the association between prenatal exposure to methylmercury (MeHg) and child neuropsychological development are heterogeneous. Underlying genetic differences across study populations could contribute to this varied response to MeHg. Studies in Drosophila have identified the cytochrome p450 3A (CYP3A) family as candidate MeHg susceptibility genes. OBJECTIVES: We evaluated whether genetic variation in CYP3A genes influences the association between prenatal exposure to MeHg and child neuropsychological development...
May 9, 2017: Environment International
https://www.readbyqxmd.com/read/28499120/characterising-bias-in-regulatory-risk-and-decision-analysis-an-analysis-of-heuristics-applied-in-health-technology-appraisal-chemicals-regulation-and-climate-change-governance
#10
Brian H MacGillivray
In many environmental and public health domains, heuristic methods of risk and decision analysis must be relied upon, either because problem structures are ambiguous, reliable data is lacking, or decisions are urgent. This introduces an additional source of uncertainty beyond model and measurement error - uncertainty stemming from relying on inexact inference rules. Here we identify and analyse heuristics used to prioritise risk objects, to discriminate between signal and noise, to weight evidence, to construct models, to extrapolate beyond datasets, and to make policy...
May 9, 2017: Environment International
https://www.readbyqxmd.com/read/28482185/effect-of-exposure-to-polycyclic-aromatic-hydrocarbons-on-basal-ganglia-and-attention-deficit-hyperactivity-disorder-symptoms-in-primary-school-children
#11
Marion Mortamais, Jesus Pujol, Barend L van Drooge, Didac Macià, Gerard Martínez-Vilavella, Christelle Reynes, Robert Sabatier, Ioar Rivas, Joan Grimalt, Joan Forns, Mar Alvarez-Pedrerol, Xavier Querol, Jordi Sunyer
BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) have been proposed as environmental risk factors for attention deficit hyperactivity disorder (ADHD). The effects of these pollutants on brain structures potentially involved in the pathophysiology of ADHD are unknown. OBJECTIVE: The aim of this study was to investigate the effects of PAHs on basal ganglia volumes and ADHD symptoms in school children. METHODS: We conducted an imaging study in 242 children aged 8-12years, recruited through a set of representative schools of the city of Barcelona, Spain...
May 5, 2017: Environment International
https://www.readbyqxmd.com/read/28478232/acute-changes-in-serum-immune-markers-due-to-swimming-in-a-chlorinated-pool
#12
Jelle Vlaanderen, Karin van Veldhoven, Laia Font-Ribera, Cristina M Villanueva, Marc Chadeau-Hyam, Lützen Portengen, Joan O Grimalt, Christian Zwiener, Dick Heederik, Xiangru Zhang, Paolo Vineis, Manolis Kogevinas, Roel Vermeulen
BACKGROUND: Exposure to disinfectants and disinfection byproducts (DBPs) due to swimming in chlorinated water has been associated with allergic and respiratory health effects, including asthma. OBJECTIVES: Biological mechanisms contributing to these associations are largely unknown. We hypothesized a potential pathway involving modulation of the immune system. METHODS: We assessed levels of immune markers (CCL11, CCL22, CXCL10, CRP, EGF, GCSF, IL-8, IL-17, IL-1RA, MPO, VEGF, Periostin) in serum collected from 30 women and 29 men before and after 40min of swimming in a chlorinated pool...
May 4, 2017: Environment International
https://www.readbyqxmd.com/read/28454882/new-frontiers-for-environmental-epidemiology-in-a-changing-world
#13
Cathryn Tonne, Xavier Basagaña, Basile Chaix, Maud Huynen, Perry Hystad, Tim S Nawrot, Remy Slama, Roel Vermeulen, Jennifer Weuve, Mark Nieuwenhuijsen
BACKGROUND: In the next 25years, transformative changes, in particular the rapid pace of technological development and data availability, will require environmental epidemiologists to prioritize what should (rather than could) be done to most effectively improve population health. OBJECTIVES: In this essay, we map out key driving forces that will shape environmental epidemiology in the next 25years. We also identify how the field should adapt to best take advantage of coming opportunities and prepare for challenges...
April 25, 2017: Environment International
https://www.readbyqxmd.com/read/28453973/determinants-of-children-s-exposure-to-pyrethroid-insecticides-in-western-france
#14
Philippe Glorennec, Tania Serrano, Morgane Fravallo, Charline Warembourg, Christine Monfort, Sylvaine Cordier, Jean-François Viel, Florent Le Gléau, Barbara Le Bot, Cécile Chevrier
Pyrethroids are insecticides frequently used in agriculture and in the home; exposure occurs through dietary and non-dietary pathways, including indoor and outdoor environmental contamination. Our objective was to study the potential determinants of pyrethroid metabolite concentrations measured in children's urine samples and in the dust of their homes. Specifically, we measured urinary metabolites from morning spot samples of 245 six-year-old children living in Brittany (France) in 2009-2012 and from dust vacuumed from the floor of their homes...
April 25, 2017: Environment International
https://www.readbyqxmd.com/read/28453972/exposure-to-ambient-pm2-5-associated-with-overall-and-domain-specific-disability-among-adults-in-six-low-and-middle-income-countries
#15
Hualiang Lin, Yanfei Guo, Yang Zheng, Xing Zhao, Zheng Cao, Steven E Rigdon, Hong Xian, Xing Li, Tao Liu, Jianpeng Xiao, Weilin Zeng, Nancy L Weaver, ZhengminMin Qian, Wenjun Ma, Fan Wu
BACKGROUND: Exposure to particulate matter pollution is associated with various cardiopulmonary diseases, which are closely related with disability. The direct relationship between air pollution and disability, however, has not been fully explored. METHODS: We used data from 45,625 participants in the Study on global AGEing and adult health in six low- and middle-income countries. The 12-item version of the World Health Organization Disability Assessment Schedule (WHODAS 2...
April 25, 2017: Environment International
https://www.readbyqxmd.com/read/28441547/phthalate-exposure-even-below-us-epa-reference-doses-was-associated-with-semen-quality-and-reproductive-hormones-prospective-marhcs-study-in-general-population
#16
Qing Chen, Huan Yang, Niya Zhou, Lei Sun, Huaqiong Bao, Lu Tan, Hongqiang Chen, Xi Ling, Guowei Zhang, Linping Huang, Lianbing Li, Mingfu Ma, Hao Yang, Xiaogang Wang, Peng Zou, Kaige Peng, Taixiu Liu, Xiefei Shi, Dejian Feng, Ziyuan Zhou, Lin Ao, Zhihong Cui, Jia Cao
BACKGROUND: Environment-Protection-Agency Reference Doses (EPA RfDs) for phthalate intakes are based on limited evidence, especially regarding low-dose male-reproductive toxicity. This study investigates the association between phthalate exposure and semen parameters and reproductive hormones in a general population with low phthalate exposure compared to the EPA RfDs. METHODS: The MARHCS (Male-Reproductive-Health-in-Chongqing-College-Students) cohort recruited 796 male students, who experienced a relocation of campuses and shifting environmental exposure...
April 22, 2017: Environment International
https://www.readbyqxmd.com/read/28434561/concentration-response-of-short-term-ozone-exposure-and-hospital-admissions-for-asthma-in-texas
#17
Ke Zu, Xiaobin Liu, Liuhua Shi, Ge Tao, Christine T Loftus, Sabine Lange, Julie E Goodman
BACKGROUND: Short-term exposure to ozone has been associated with asthma hospital admissions (HA) and emergency department (ED) visits, but the shape of the concentration-response (C-R) curve is unclear. METHODS: We conducted a time series analysis of asthma HAs and ambient ozone concentrations in six metropolitan areas in Texas from 2001 to 2013. Using generalized linear regression models, we estimated the effect of daily 8-hour maximum ozone concentrations on asthma HAs for all ages combined, and for those aged 5-14, 15-64, and 65+years...
April 20, 2017: Environment International
https://www.readbyqxmd.com/read/28414931/human-adipose-tissue-levels-of-persistent-organic-pollutants-and-metabolic-syndrome-components-combining-a-cross-sectional-with-a-10-year-longitudinal-study-using-a-multi-pollutant-approach
#18
Vicente Mustieles, Mariana F Fernández, Piedad Martin-Olmedo, Beatriz González-Alzaga, Andrés Fontalba-Navas, Russ Hauser, Nicolás Olea, Juan P Arrebola
We aimed to assess the influence of long-term exposure to POPs on the risk of metabolic syndrome, combining a cross-sectional with a 10-year longitudinal follow-up design. Residues of eight POPs were quantified in adipose tissue samples from 387 participants recruited between 2003 and 2004 in Granada province (Spain). The outcome ("metabolically compromised") was defined as having ≥1 diagnosis of type 2 diabetes, hypertension, hypertriglyceridemia, and/or low HDL cholesterol. The cross-sectional analysis was conducted in the initial cohort, while the 10-year longitudinal analysis was conducted in those 154 participants free of any of the so-mentioned metabolic diseases and classified as "metabolically healthy" at recruitment...
April 14, 2017: Environment International
https://www.readbyqxmd.com/read/28412010/assessment-of-impact-of-urbanisation-on-background-radiation-exposure-and-human-health-risk-estimation-in-kuala-lumpur-malaysia
#19
M S M Sanusi, A T Ramli, W M S W Hassan, M H Lee, A Izham, M N Said, H Wagiran, A Heryanshah
Kuala Lumpur has been undergoing rapid urbanisation process, mainly in infrastructure development. The opening of new township and residential in former tin mining areas, particularly in the heavy mineral- or tin-bearing alluvial soil in Kuala Lumpur, is a contentious subject in land-use regulation. Construction practices, i.e. reclamation and dredging in these areas are potential to enhance the radioactivity levels of soil and subsequently, increase the existing background gamma radiation levels. This situation is worsened with the utilisation of tin tailings as construction materials apart from unavoidable soil pollutions due to naturally occurring radioactive materials in construction materials, e...
April 12, 2017: Environment International
https://www.readbyqxmd.com/read/28411585/the-association-between-air-pollution-and-type-2-diabetes-in-a-large-cross-sectional-study-in-leicester-the-champions-study
#20
Gary O'Donovan, Yogini Chudasama, Samuel Grocock, Roland Leigh, Alice M Dalton, Laura J Gray, Thomas Yates, Charlotte Edwardson, Sian Hill, Joe Henson, David Webb, Kamlesh Khunti, Melanie J Davies, Andrew P Jones, Danielle H Bodicoat, Alan Wells
BACKGROUND: Observational evidence suggests there is an association between air pollution and type 2 diabetes; however, there is high risk of bias. OBJECTIVE: To investigate the association between air pollution and type 2 diabetes, while reducing bias due to exposure assessment, outcome assessment, and confounder assessment. METHODS: Data were collected from 10,443 participants in three diabetes screening studies in Leicestershire, UK. Exposure assessment included standard, prevailing estimates of outdoor nitrogen dioxide and particulate matter concentrations in a 1×1km area at the participant's home postcode...
April 12, 2017: Environment International
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