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Irish Journal of Medical Science

Jürgen Mulsow
Approximately one-third of patients with Crohn's disease have a distinct fibrostenosing phenotype predisposing them to recurrent intestinal stricture formation. The intestinal fibroblast was thought to play a critical role in the abnormal wound healing which ends in stricture formation. Recognising this, a laboratory-based research study was initiated at the Mater Misericordiae Hospital and University College Dublin with the aim of investigating the key steps in intestinal fibroblast-mediated stricture pathogenesis...
July 18, 2018: Irish Journal of Medical Science
Andrea K Bowe, Miriam Owens, Mary B Codd, Brian A Lawlor, Ronan W Glynn
BACKGROUND: Physical activity represents a modifiable behaviour which may be associated with increased likelihood of experiencing positive mental health. AIMS: The aim of this study was to examine the association between self-rated physical activity and subjective indicators of both positive and negative mental health in an Irish adult population. METHODS: Based on data from a population-based, observational, cross-sectional study, participants were categorised using the International Physical Activity Questionnaire (IPAQ) into those who reported that they did and did not meet recommended physical activity requirements...
July 17, 2018: Irish Journal of Medical Science
Ray O'Connor, Cliodhna O'Callaghan, Roisin McNamara, Umbreen Salim
BACKGROUND: Health is information-intensive. Reliable health care depends on access to this information in a timely and accurate manner. A standardised data set for clinical discharge summaries is essential to optimise the care the patient receives, particularly at discharge. The Irish Health Information and Quality Authority (HIQA) have recently developed a national standard for patient discharge summaries. AIMS: Our aim was to assess the current quality of discharge summaries being received, determine the main areas of concern and establish the areas to improve patient safety...
July 17, 2018: Irish Journal of Medical Science
Amirah A Haziman, Shankarii Ravinderan, Thanggamalar Thangavelu, Warren Thomas
Colorectal cancer (CRC) is a malignancy whose incidence is increasing globally, and there is a gender difference in the increasing risk. Evidence from hormone replacement therapy studies points to a role for circulating estrogens in suppressing the development of CRC. Estrogen receptor-β has been identified as a tumor suppressor, but other actions of estrogen may also contribute to the difference in CRC incidence between men and women. The KCNQ1/KCNE3 potassium channel is regulated by estrogen in order to modulate chloride secretion during the menstrual cycle; the effect of estrogen on the colon is to promote fluid conservation during the implantation window...
July 17, 2018: Irish Journal of Medical Science
William P Tormey
No abstract text is available yet for this article.
July 16, 2018: Irish Journal of Medical Science
Nermeen Abuelsoud
BACKGROUND: Improvement in the quality of the medication management process is a crucial component of twenty-first-century medicine. AIM: To improve the quality of medication management process within pediatric specialty through designing a quality improvement project for the pharmaceutical care services in a children' hospital to solve the drug-related problems during drug prescribing, administration, and monitoring. METHODS: A total of 900 medical files were evaluated (100 file/month) from the pediatric medical ward to detect any medication errors during prescribing, administration, or monitoring of the drugs...
July 14, 2018: Irish Journal of Medical Science
Gavin C Harewood, Carthage Moran, Stephen Patchett, Karen Hartery, Leonardo Areas Venaas, Athena Wright Ballester, Millicent Croman, Aoibhlinn O'Toole
BACKGROUND: With the emergence of alternative payment systems replacing the traditional funding models, the value of physician activity is scrutinized more closely. Attempts have been made to quantify the value of endoscopists' activity; there is little in the medical literature describing gastroenterologists' value in the outpatient setting. AIMS: To characterize the value of clinical activity of gastroenterologists in the outpatient setting. METHODS: The value of clinical activity of ten gastroenterologists in an academic medical center was estimated...
July 11, 2018: Irish Journal of Medical Science
Antoinette Daly, Dermot Walsh
This paper reviews data on admissions to Irish psychiatric units and hospitals for those suffering from organic mental disorders, in particular dementia, over the course of the last half century. Admission and census data from the National Psychiatric In-patient Reporting System (NPIRS) from 1963 to 2016 are examined and discussed in light of Ireland's ageing population. The NPIRS database was established in the 1960s to record admission and discharge activity in Irish psychiatric units and hospitals. Admission data from the database are presented in 5-yearly intervals from 1965 to 2015, while census data are presented for 1963 and 2016...
July 10, 2018: Irish Journal of Medical Science
Andrew J Hughes, Louise Brent, Regien Biesma, Paddy J Kenny, Conor J Hurson
BACKGROUND AND AIMS: Current best practice states that hip fracture patients should undergo surgery within 48 hours to minimise perioperative complications. There are 10 emergency departments (EDs) in Ireland that receive hip fracture patients without a trauma and orthopaedic surgery unit on site. Idle periods and duplicated preoperative investigations can lead to a prolonged time to surgery. The aim of this study was to identify the effect of admission route on the time to surgery, length of stay and pressure ulcer development in patients who sustain a hip fracture in Ireland...
July 4, 2018: Irish Journal of Medical Science
Di Zhao, Hui Liu, Pingshuan Dong
OBJECTIVE: The comparison of antihypertensive effects between azilsartan and olmesartan in patients with essential hypertension has been investigated in several studies. The results were not consistent. We performed this meta-analysis determining the antihypertensive effect of azilsartan versus olmesartan in patients with essential hypertension. METHODS: Pubmed, Web of Science, and Cochrane Central were searched for all published randomized studies comparing the antihypertensive effects between azilsartan and olmesartan in patients with essential hypertension...
July 3, 2018: Irish Journal of Medical Science
Roy K Philip
No abstract text is available yet for this article.
June 29, 2018: Irish Journal of Medical Science
Anne Marie Shine, Daragh Gerard Finn, Noeleen Allen, Colin J McMahon
The original version of this article inadvertently used early drafts of Figs. 1 and 2. The correct figures are shown here. The original article has been corrected.
June 29, 2018: Irish Journal of Medical Science
Katie E O' Sullivan, Robert Fleck, Gaia Vigano, Gerard J Fitzmaurice, Paul Cullen, Daniyal Arshad, Mohammad Abdelrahman, Alfred E Wood, Jonathan Mc Guinness, J Mark Redmond, Lars Nölke
BACKGROUND: We describe the long-term results of partial atrioventricular septal defect (AVSD) repair in a single centre encompassing a 22-year period. Described are rates of survival, reoperation and complications. METHODS: We performed a retrospective review of 556 patients undergoing AVSD repair to identify the 51 patients who underwent partial AVSD repair in Our Lady's Children's Hospital, Crumlin, Ireland, between 1993 and 2015 with long-term follow-up where available...
June 25, 2018: Irish Journal of Medical Science
Chwanrow Karim Baban, Liam Devane, James Geraghty
Developed countries face significant population ageing in the near future. Within 20 years, the average age will approach 50 years and the largest population cohort will be those over 65 years. The incidence of breast cancer increases with age, with a risk in women of 0.44% by the age of 30, 3.82% by the age of 70 and 10% by the age of 80. Breast cancer is responsible for one out of every three cancer-related deaths. Elderly patients have higher mortality rates and most breast cancer-related deaths are observed in women over 65...
June 23, 2018: Irish Journal of Medical Science
David A Crosby, Sarah M Cullen, Cathy M Allen
No abstract text is available yet for this article.
June 21, 2018: Irish Journal of Medical Science
Robbie S R Woods, Lina Geyer, Ana Ionescu, Deirdre Callanan, Patrick Sheahan
BACKGROUND: The optimal treatment for oropharyngeal squamous cell carcinoma (OPSCC) is controversial. There is increasing evidence that, in selected cases, minimally invasive transoral surgery can offer improved functional outcomes, with equivalent oncologic outcomes, compared to chemoradiotherapy. AIMS: We report the outcomes of transoral laser microsurgery (TLM) for treatment of OPSCC at our institution. METHODS: Patients with OPSCC undergoing TLM at the South Infirmary Victoria University Hospital, Cork, between 2010 and 2016, were identified from an institutional database...
June 21, 2018: Irish Journal of Medical Science
Charles H Knowles
This review addresses three main questions: (1) Why is anorectal sensory function important in humans? (2) What is the evidence for anorectal sensory dysfunction in disease? (3) Can anorectal sensory function be modified for therapeutic benefit?
June 20, 2018: Irish Journal of Medical Science
Hande Gezer, Ozgur Zeliha Karaahmet, Eda Gurcay, Deniz Dulgeroglu, Aytul Cakci
BACKGROUND AND AIMS: To compare the effects of aerobic exercise and conventional exercise that were applied during the rehabilitation process on the aerobic capacity, motor function, activity limitation, quality of life, depression level, and sleep quality in subacute stroke patients. METHODS: The patients were divided into two groups; aerobic exercise group (n = 22) or conventional exercise group (n = 20). Both groups participated in a conventional stroke rehabilitation program; however, aerobic exercise program was applied only for the patients in group 1...
June 19, 2018: Irish Journal of Medical Science
Frances Colreavy
No abstract text is available yet for this article.
June 19, 2018: Irish Journal of Medical Science
Robert N Kerley, Siun O'Flynn
INTRODUCTION: The 2011 Appropriate Use Criteria (AUC) were developed by the American Society of Echocardiography (ASE) to provide guidance for referring physicians in response to growing concerns about unnecessary transthoracic echocardiogram (TTE) requests. Very few studies have assessed how medical centers overseas perform against AUC. Evidence is now emerging that inappropriate referral rates in Europe are similar to those reported in the US. OBJECTIVE: This study systematically reviewed published evidence to identify (1) whether the 2011 AUC are applicable to medical centers outside the US (2) the level of adherence to the AUC across multiple centers, (3) the main factors which cause deviation from AUC, (4) any changes in referral rates since the publication of AUC, and (5) any factors and/or intervention strategies which promote adherence to AUC...
June 18, 2018: Irish Journal of Medical Science
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