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Irish Journal of Medical Science

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https://www.readbyqxmd.com/read/28389990/high-mobility-group-box-1-regulates-cytoprotective-autophagy-in-a-mouse-spermatocyte-cell-line-gc-2spd-exposed-to-cadmium
#1
Z Ou, Y Chen, X Niu, W He, B Song, D Fan, X Sun
BACKGROUND: Cadmium (Cd) is an environmental and industrial pollutant that induces a broad spectrum of toxicological effects, influences a variety of human organs, and is associated with poor semen quality and male infertility. Increasing evidence demonstrates that Cd induces testicular germ cell apoptosis in rodent animals. However, the specific effect of Cd exposure on autophagy in germ cells is poorly understood. METHODS: We investigate the role of high-mobility group box 1 protein (HMGB1), a ubiquitous nuclear protein, on Cd-evoked autophagy in a mouse spermatocyte cell line (GC-2spd)...
April 7, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28343276/an-updated-review-of-cardiac-devices-in-heart-failure
#2
REVIEW
C Murphy, H Zafar, F Sharif
BACKGROUND: Heart failure has the highest rates of adult hospitalisations, the highest mortality rates and significant costs associated with its care. The cost of heart failure is expected continue to grow on a global scale, with $108 billion spent on heart failure in 2012. Mortality rates are high, with incident cases of heart failure resulting in 30% 1-year mortality, and in hospital mortality of acute heart failure, 28%. METHODS AND RESULTS: This article reviews the devices currently in use for the treatment of heart failure, as well as those that are under investigation...
March 25, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28342055/the-analysis-of-lncrna-hotair-rs12826786-c-t-polymorphism-and-gastric-cancer-susceptibility-in-a-turkish-population-lack-of-any-association-in-a-hospital-based-case-control-study
#3
Y Ülger, E Dadaş, B Yalinbaş Kaya, A T Sümbül, A Genç, S Bayram
BACKGROUND: The HOX transcript antisense intergenic RNA (HOTAIR), a well-known long noncoding RNA (lncRNA), has been widely identified to participate in pathogenesis of multiple cancers. An aberrant up-regulation and biological functions have been observed in gastric cancer (GC). A common single nucleotide polymorphism (SNP) (rs12826786 C>T) at the HOTAIR has been reported to influence HOTAIR expression, but its association with GC has yet to be investigated in Turkish population. AIM: The aim of the present study was to investigate whether HOTAIR rs12826786 C>T polymorphism could be involved in the risk of GC susceptibility in Turkish population...
March 24, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28321641/transformed-follicular-lymphoma-tfl-consolidation-therapy-may-improve-survival
#4
E Elhassadi, R Flavin, P Browne, E Conneally, P Hayden, F Quinn, E Higgins, E Vandenberghe
PURPOSE: Retrospective study to evaluate the outcome of patients with transformed follicular lymphoma (tFL) treated with rituximab-containing chemotherapy and consolidation. PATIENTS AND METHODS: Patients diagnosed with tFL from 2003 to 2013 treated with consolidation therapy with last follow-up in December 2015 were identified from the institutional lymphoma database and included in this study. Data collected included age, gender, stage, interval to tFL diagnosis, R-IPI score, histological diagnosis and therapy...
March 21, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28283862/failure-to-control-hypercholesterolaemia-in-the-irish-adult-population-cross-sectional-analysis-of-the-baseline-wave-of-the-irish-longitudinal-study-on-ageing-tilda
#5
C Murphy, E Shelley, A M O'Halloran, T Fahey, R A Kenny
BACKGROUND: Hypercholesterolaemia is an important modifiable risk factor for cardiovascular disease (CVD) which requires monitoring and management at a population level. AIMS: This study aims to describe the distribution of serum cholesterol in a community living population of older adults in Ireland and to examine the awareness, treatment and control of hypercholesterolaemia according to CVD risk status. METHOD: This is a cross-sectional study in a nationally representative sample of adults aged 50-79 years (n = 5287)...
March 10, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28281040/the-effect-of-rapid-access-prostate-clinics-on-the-outcomes-of-gleason-7-prostate-cancer-does-earlier-diagnosis-lead-to-better-outcomes
#6
M P Broe, J C Forde, M S Inder, D J Galvin, D W Mulvin, D M Quinlan
INTRODUCTION: Rapid Access Prostate Clinics (RAPC) were introduced in Ireland by the National Cancer Control Programme bringing about expedited referral pathways and increased detection rates of prostate cancer. Lower Gleason (G) grade at diagnosis due to RAPC has been previously reported but grade at prostatectomy has not been assessed. The aim of this study was to assess the impact of RAPC on the outcomes of patients with G7 disease on radical prostatectomy (RP). METHODS: A retrospective analysis was carried out of all RPs performed over a 9-year period (2006-2014)...
March 9, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28281039/proceedings-of-the-rami-section-of-otorhinolaryngology-head-and-neck-surgery-orl-hns-spring-meeting-friday-9th-december-2016-education-and-research-centre-royal-victoria-eye-and-ear-hospital-adelaide-road-dublin-2
#7
https://www.readbyqxmd.com/read/28271279/an-international-assessment-of-trainee-experience-confidence-and-comfort-in-operative-vaginal-delivery
#8
D A Crosby, A Sarangapani, A Simpson, R Windrim, A Satkunaratnam, M F Higgins
AIM: The aim of this study was to assess Irish and Canadian obstetricians in training ("trainees") experience, confidence, and comfort in performing operative vaginal delivery (OVD). STUDY DESIGN: Trainees in Obstetrics and Gynaecology in the University of Toronto and the Royal College of Physicians of Ireland (RCPI) were invited to participate in an anonymous online survey reviewing experience as primary operator of OVD. Trainee confidence and comfort was self-assessed based upon their last few OVDs...
March 7, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28271278/patient-response-to-physician-expressions-of-uncertainty-a-systematic-review
#9
REVIEW
R McGovern, D Harmon
BACKGROUND: The consequences of uncertainty are extensive with the potential to influence a multitude of issues such as patient expectations, diagnosis, treatment decisions, patient confidence and satisfaction and ultimately patient compliance. AIMS: To review the relevant literature pertaining to physician expressions of uncertainty and its effects on patients. METHODS: A search was conducted in July 2016 of electronic databases; PsycINFO, PsycARTICLES, MEDLINE and Embase...
March 7, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28265854/general-poster-session
#10
(no author information available yet)
No abstract text is available yet for this article.
March 6, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28260154/the-cost-and-mortality-of-hip-fractures-in-centenarians
#11
J Moore, O Carmody, B Carey, J A Harty, D Reidy
BACKGROUND: Centenarians are the fastest rising age group in Ireland. Hip fractures most commonly affect older adults and are associated with significant morbidity and mortality, as well as the financial cost of healthcare resources. Despite this, very little is known regarding hip fractures in centenarians. The aim of this study was to investigate our experience with hip fractures in this group and to record the cost of treating these fractures to identify both the social and economic impact these injuries impose on the health system...
March 4, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28260153/effects-of-different-methods-of-using-pneumatic-tourniquet-in-patients-undergoing-total-knee-arthroplasty-a-randomized-control-trial
#12
Y Zhang, D Li, P Liu, X Wang, M Li
BACKGROUND: The goal of this work was to investigate the effects of different methods of using pneumatic tourniquet on reducing blood loss in patients undergoing cemented total knee arthroplasty (TKA). METHODS: One hundred and fifty patients undergoing unilateral cemented TKA were randomly divided into three groups (50 patients per group). The tourniquet was used during the entire operation (Group A), used from the beginning of operation to the completion of joint replacement (Group B), and from the beginning of osteotomy to the completion of arthroplasty (Group C)...
March 4, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28255806/audit-of-aspects-of-practice-in-relation-to-patients-with-suspected-community-onset-blood-stream-infection
#13
M A Reza, M Cormican
BACKGROUND: Community-onset blood stream infection (C-BSI) is an important cause of sepsis. The urinary tract is an important source for C-BSI. Urinary catheters are a recognized risk factor. Blood culture is the critical diagnostic test. Prompt effective antimicrobial therapy is a key intervention. We reviewed practice in relation to patients presenting with suspected C-BSI. AIM: To review practice in relation to patients presenting with suspected C-BSI. METHODS: Patients were those with blood cultures (BC) submitted from the emergency department over 4 weeks...
March 2, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28238200/left-cardiac-sympathetic-denervation-case-series-and-technical-report
#14
C McNamara, P Cullen, M Rackauskas, R Kelly, K E O'Sullivan, J Galvin, D Eaton
BACKGROUND: Left cardiac sympathetic denervation (LCSD) is a surgical procedure that has been shown to have an antiarrhythmic and antifibrillatory effect. Evidence indicating its antiarrhythmic effect has been available for over 100 years. It involves the removal of the lower half of the stellate ganglion and T2-T4 of the sympathetic ganglia and is carried out as either a unilateral or bilateral procedure. With advancements in thoracic surgery, it can be safely performed via a minimally invasive Video-Assisted Thoracoscopic Surgery (VATS) approach resulting in significantly less morbidity and a shortened inpatient stay...
February 25, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28238199/increased-number-of-community-living-older-adults-attending-an-emergency-department-with-falls-and-fractures-north-dublin-experience
#15
C W Fan, J Duggan, D Rodger, E Brazil, F McCarthy
BACKGROUND: The number of attendances to emergency department (ED) due to falls and fractures increases as the population ages. The community-based falls prevention strategy may reduce the number of falls requiring medical attention. AIM: Our aim was to determine the changes over time in community-living older adults on the number of attendances to an urban ED over a 5 year period. METHODS: Community-living adults aged ≥65 years from a catchment attending with falls and fractures to an ED in 2010 and 2014 were identified through an electronic patient record...
February 25, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28233168/evaluating-cardioversion-outcomes-for-atrial-fibrillation-on-novel-oral-anticoagulants-versus-warfarin-experience-at-a-tertiary-referral-centre
#16
Z Sharif, B Srinivas, I Tiedt, N Ryan, M Awadalla, V Sullivan, D P Foley, T Gumbrielle, B McAdam, R G Sheahan
BACKGROUND: Current guidelines recommend anticoagulation prior to cardioversion in patients with atrial fibrillation of >48 h or unknown duration to reduce thromboembolic risk. Therapeutic anticoagulation with warfarin, with INR between 2 and 3, is consistently achieved in approximately 60% of patients. AIMS: We evaluated outcomes and assessed differences in direct current cardioversion (DCCV) in patients treated with warfarin and novel oral anticoagulants (NOAC) at our institution...
February 24, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28229286/definitions-and-resistance-rate-difference
#17
LETTER
E Guclu, O Karabay
No abstract text is available yet for this article.
February 22, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28224360/proceedings-of-the-rami-section-of-healthcare-informatics-students-meeting-friday-17th-june-2016-setanta-house-dublin
#18
(no author information available yet)
No abstract text is available yet for this article.
February 21, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28224359/dysphagia-screening-in-acute-stroke-care-among-non-consultant-hospital-doctors
#19
LETTER
C Osuafor, J Molloy, S Murphy
No abstract text is available yet for this article.
February 21, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28220370/the-effect-of-candesartan-on-pentraxin-3-plasma-levels-as-marker-of-endothelial-dysfunction-in-patients-with-essential-arterial-hypertension
#20
V Buda, M Andor, C Cristescu, M Voicu, F Cochera, P Tuduce, L Petrescu, M C Tomescu
BACKGROUND: In the last decades, the studies performed on the field of endothelial dysfunction confirmed the fact that the starting point of this pathology is the inflammation. Several inflammatory biomarkers had been discovered and studied, ones showing systemic inflammation, and others being more specific biomarkers and showing the local inflammation. Pentraxin-3 (PTX3) is a new inflammatory biomarker, from the same family as high-selectivity C-reactive protein (hs-CRP), but it is a more specific biomarker, due to its local production: the endothelial cells and not the liver like in the case of hs-CRP...
February 21, 2017: Irish Journal of Medical Science
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