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Journal of Endocrinological Investigation

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https://www.readbyqxmd.com/read/28444621/head-of-an-old-goitrous-woman
#1
LETTER
Enio Martino
No abstract text is available yet for this article.
April 25, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28434158/physical-performance-in-newly-diagnosed-hypothyroidism-a-pilot-study
#2
D Gallo, E Piantanida, G Veronesi, A Lai, L Sassi, V Lombardi, E Masiello, P Premoli, E Bianconi, C Cusini, S Rosetti, M L Tanda, A Toniolo, M Ferrario, L Bartalena
OBJECTIVE: Hypothyroidism is complicated by neuromuscular symptoms (myalgias, slowness of movements, and tiredness) and signs (easy fatigability and cramps), which may have a negative impact on general well-being and quality of life. In a pilot, prospective, controlled study, we investigated the features of muscle dysfunction in hypothyroidism by disease questionnaire, biochemical measures, and physical performance tests. MATERIALS AND METHODS: Fifty-seven consecutive patients with newly diagnosed hypothyroidism were enrolled, 27 subclinical (S-Hypo) and 30 overt (O-Hypo)...
April 22, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28432675/transoral-thyroidectomy-advantages-and-limitations
#3
G Dionigi, R P Tufano, J Russell, H Y Kim, E Piantanida, A Anuwong
In this opinion paper of the Journal of Endocrinological Investigation, leading experts in the field report on their current clinical experience with a novel approach for thyroid gland surgery, namely, "transoral thyroidectomy" (TOT). This feasible and novel surgical procedure does not require visible incisions and is, therefore, a truly scarless surgery. Patients meeting the following criteria can be considered as candidates for TOT: (a) an ultrasonographically (US) estimated thyroid diameter ≤10 cm; (b) US-estimated gland volume ≤45 mL; (c) nodule size ≤50 mm; (d) presence of a benign tumor such as a thyroid cyst or a single- or multi-nodular goiter; (e) Bethesda 3 and/or 4 category and (f) papillary microcarcinoma without the evidence of metastasis...
April 21, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28421564/erratum-to-long-term-safety-and-efficacy-of-omnitrope-%C3%A2-in-adults-with-growth-hormone-deficiency-italian-interim-analysis-of-the-patro-adults-study
#4
D Ferone, E Profka, V Gasco, M R Ambrosio, A Colao, C Di Somma, E Puxeddu, G Arnaldi, C Pagano, E Zecchi, A Pietropoli, P Beck-Peccoz
No abstract text is available yet for this article.
April 18, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28401529/influence-of-exercise-intervention-on-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#5
REVIEW
J Zheng, H Wang, M Ren
AIMS: Exercise intervention might be a promising approach to prevent gestational diabetes mellitus. However, the results remained controversial. We conducted a systematic review and meta-analysis to explore the effect of exercise intervention on gestational diabetes mellitus. METHODS: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of exercise intervention on gestational diabetes mellitus were included...
April 12, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28401528/association-between-low-c-peptide-and-fragility-fractures-in-postmenopausal-women-without-diabetes
#6
Y Ferro, C Russo, D Russo, C Gazzaruso, A Coppola, P Gallotti, V Zambianchi, M Fodaro, S Romeo, E Galliera, M G Marazzi, M M C Romanelli, S Giannini, A Pujia, T Montalcini
PURPOSE: C-peptide has been shown to exert several, previously unknown, biological effects. A recent cross-sectional study demonstrated an association between low C-peptide serum levels and low lumbar bone density of postmenopausal women not affected by diabetes. To date, very little research attention has been directed toward the association between C-peptide and osteoporotic fractures. To contribute toward filling this gap, we investigated the association between C-peptide and fractures in postmenopausal women...
April 11, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28401527/fluid-intelligence-traits-of-personality-and-personality-disorders-in-a-cohort-of-adult-ks-patients-with-the-classic-47-xxy-karyotype
#7
D Liberato, S Granato, D Grimaldi, F M Rossi, N Tahani, D Gianfrilli, A Anzuini, A Lenzi, G Cavaggioni, A F Radicioni
PURPOSE: Klinefelter's syndrome (KS) is associated with specific neurobehavioral features and personality traits. The aim of our study was to investigate fluid intelligence, personality traits and personality disorders (PD) and possible correlations with testosterone in a cohort of adult KS patients. METHODS: We analyzed 58 adult KS patients with the classic 47, XXY karyotype. The Structured Clinical Interview for axis II disorders was used to assess DSM IV personality disorders...
April 11, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28401526/the-fight-between-a-dwarf-and-a-stork-mosaic-i-century-bc
#8
LETTER
Enio Martino
No abstract text is available yet for this article.
April 11, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28397185/validation-of-the-italian-quality-of-life-in-short-stature-youth-qolissy-questionnaire
#9
J Quitmann, A Giammarco, M Maghnie, F Napoli, I Di Giovanni, C Carducci, A Mohn, M Bullinger, R Sommer
PURPOSE: The Quality of Life in Short Stature Youth (QoLISSY) questionnaire is a disease-specific instrument developed to assess health-related quality of life (HrQoL) in children with short stature. While the original instrument was simultaneously developed in five European countries, this study describes the results of the Italian QoLISSY translation, cultural adaptation, and validation. METHODS: Focus group discussions and a cognitive debriefing process with children (N = 12) diagnosed with growth hormone deficiency or idiopathic short stature and one parent each, as well as parents of younger children (N = 20) were conducted to examine the linguistic and content validity of the Italian version...
April 10, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28397184/quality-of-life-after-thyroid-surgery
#10
S Dogan, N A Sahbaz, N Aksakal, F Tutal, B C Torun, N K Yıldırım, M Özkan, B Ozcinar, Y Erbil
PURPOSE: The purpose of this study was to inquire how patients' quality of life is affected after thyroid surgery and the factors involved. METHODS: A semi-structured questionnaire and the World Health Organization Quality of Life Scale (WHOQOL-BREF) were applied to 101 patients prior to surgery. Thereafter data was collected in the early and again in the late post-operative period. RESULTS: Mean general health score for pre-operative quality of life was 6...
April 10, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28397183/prepubertal-ultra-low-dose-estrogen-therapy-is-associated-with-healthier-lipid-profile-than-conventional-estrogen-replacement-for-pubertal-induction-in-adolescent-girls-with-turner-syndrome-preliminary-results
#11
Anna Ruszala, Malgorzata Wojcik, Agata Zygmunt-Gorska, Dominika Janus, Joanna Wojtys, Jerzy B Starzyk
PURPOSE: The metabolic effects of prepubertal low-dose estrogen replacement (LE) therapy in Turner syndrome (TS) have not been fully investigated to date. The present study aimed to compare glucose and lipids metabolism in adolescents with TS on LE and conventional estrogen replacement (CE). METHODS: In 14 TS (mean age 13.8), LE (17β-estradiol, 62.5 μg daily) was introduced before age 12 (mean age 10.5), and followed by a pubertal induction regimen after age 12, and in 14 CE was started after age 12 (mean 14, SD 1...
April 10, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28393316/profiling-of-selenium-absorption-and-accumulation-in-healthy-subjects-after-prolonged-l-selenomethionine-supplementation
#12
C Di Dato, D Gianfrilli, E Greco, M Astolfi, S Canepari, A Lenzi, A M Isidori, E Giannetta
PURPOSE: Autoimmune thyroiditis and its complications for the reproductive system are a growing problem. Selenium is a common ingredient in numerous food supplements recommended for thyroiditis and pregnancy. A fast, simple method to measure serum selenium concentration will improve knowledge of its pharmacokinetics and toxicity. AIM: To validate a useful method to measure serum selenium concentration and to study selenium absorption and accumulation in a prospective interventional study of prolonged treatment...
April 9, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28391585/influence-of-vitamin-d-levels-on-the-cardiovascular-profile-of-hypogonadal-men
#13
G Tirabassi, M Cutini, G Salvio, G Cerqueni, A Lenzi, G Balercia
PURPOSE: A large body of evidence suggests a role for vitamin D in conditioning cardiovascular risk. Therefore, it can be hypothesized that vitamin D might also play a role in influencing the metabolic profile of hypogonadal men. In this work, we aimed at evaluating if any relationship exists between vitamin D levels and cardiovascular parameters in male hypogonadism. METHODS: Hypogonadal patients attending our andrology unit were retrospectively reviewed. Clinical and biochemical parameters were evaluated...
April 8, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28391584/the-effect-of-ppar%C3%AE-agonist-on-sglt2-and-glucagon-expressions-in-alpha-cells-under-hyperglycemia
#14
M Kim, E J Lee, H M Shin, H S Jung, T K Kim, T N Kim, M J Kwon, S H Lee, B D Rhee, J H Park
BACKGROUND: Although sodium glucose cotransporter 2 (SGLT2) inhibitors have many beneficial effects for type 2 diabetes, including decreased cardiovascular death, recent reports that they increased glucagon through SGLT2 inhibition raised some concern. Troglitazone, Peroxisome proliferator-activated receptor γ (PPAR-γ) agonist, was reported to increase SGLT2 in renal proximal tubule cells, but its role on pancreatic alpha cells have not been reported. We investigated the effect of troglitazone on SGLT2 expression in alpha cells and subsequent glucagon regulation in hyperglycemia...
April 8, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28386795/-metabolic-and-cardiovascular-response-to-exercise-in-patients-with-type-1-diabetes
#15
I Turinese, P Marinelli, M Bonini, M Rossetti, G Statuto, T Filardi, A Paris, A Lenzi, S Morano, P Palange
PURPOSE: Physical activity is an effective therapeutic tool for cardiovascular risk prevention. However, exercise aerobic capacity of patients with type 1 diabetes (T1DM) has not been thoroughly investigated. Aim of the present study is to evaluate exercise aerobic capacity in patients with T1DM compared to a normal control population. METHODS: This observational study included 17 T1DM patients and 17 matched healthy volunteers. Cardiopulmonary exercise test (CPET) was conducted on an electronically-braked cycle ergometer...
April 6, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28382505/association-of-established-hypothyroidism-associated-genetic-variants-with-hashimoto-s-thyroiditis
#16
A Barić, L Brčić, S Gračan, V Torlak Lovrić, I Gunjača, M Šimunac, M Brekalo, M Boban, O Polašek, M Barbalić, T Zemunik, A Punda, V Boraska Perica
PURPOSE: Hashimoto's thyroiditis (HT) as a chronic autoimmune disease of the thyroid gland is the most common cause of hypothyroidism. Since HT and hypothyroidism are closely related, the main aim of this study was to explore the association of established hypothyroidism single-nucleotide polymorphisms (SNPs) with HT. METHODS: The case-control dataset included 200 HT cases and 304 controls. Diagnosis of HT cases was based on clinical examination, measurement of thyroid antibodies (TgAb, TPOAb), hormones (TSH and FT4) and ultrasound examination...
April 5, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28382504/binding-of-thyroglobulin-tg-to-the-low-density-lipoprotein-receptor-associated-protein-rap-during-the-biosynthetic-pathway-prevents-premature-tg-interactions-with-sortilin
#17
R Botta, S Lisi, G Rotondo Dottore, P Vitti, M Marinò
OBJECTIVE: Sortilin, a Vps10p family member, is expressed by thyroid epithelial cells (TEC), where it binds to internalized thyroglobulin (Tg) molecules. Premature binding of Tg to sortilin during biosynthesis may cause intracellular retention of Tg. Such a premature interaction may be prevented by one or more inhibitor/s. Because both sortilin and Tg bind to the low-density lipoprotein receptor-associated protein (RAP), we investigated whether RAP serves such a function. METHODS: Immunofluorescence staining for sortilin, Tg, and RAP was performed in FRTL-5 cells...
April 5, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28378156/a-randomized-open-label-controlled-trial-to-evaluate-the-antimicrobial-and-surgical-effect-of-co2-laser-treatment-in-diabetic-infected-foot-ulcers-dulcis-diabetic-ulcer-co2-laser-and-infections-study
#18
M Monami, A Scatena, S Zannoni, S Aleffi, C Mirabella, L Giannoni, E Mannucci
AIM: Debridement of fibrin and necrotic tissue from the ulcer surface is an important component of the treatment of diabetic ulcers. A possible alternative to standard lancets is represented by CO2 laser, which vaporizes necrotic tissues together with any pathogen. The present trial is aimed at verifying the effect of a CO2 laser on bacterial load in the debridement of infected diabetic foot ulcers. METHODS: In this open-label randomized controlled trial (NCT02677779), patients with diabetes and an infected foot ulcers were randomized to either CO2 laser or traditional debridement...
April 4, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28374221/less-is-more-time-to-expand-the-indications-for-minimally-invasive-video-assisted-parathyroidectomy
#19
S Bakkar, V Matteucci, C Corsini, S Pagliaro, P Miccoli
PURPOSE: Minimally invasive video-assisted parathyroidectomy (MIVAP) is one of the most widespread targeted parathyroid surgeries for primary hyperparathyroidism (PHP). The aim of this study was to assess its limits and propose an expansion of its indications in the management of parathyroid pathology. METHODS: A retrospective analysis of 77 consecutive patients who underwent MIVAP for PHP between Jan and Oct 2016 was conducted. The adequacy of the procedure and/or the need to convert to a standard cervicotomy was the main outcome of interest...
April 3, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28365864/long-term-blood-glucose-monitoring-with-implanted-telemetry-device-in-conscious-and-stress-free-cynomolgus-monkeys
#20
B Wang, G Sun, W Qiao, Y Liu, J Qiao, W Ye, H Wang, X Wang, R Lindquist, Y Wang, Y-F Xiao
AIMS: Continuous blood glucose monitoring, especially long-term and remote, in diabetic patients or research is very challenging. Nonhuman primate (NHP) is an excellent model for metabolic research, because NHPs can naturally develop Type 2 diabetes mellitus (T2DM) similarly to humans. This study was to investigate blood glucose changes in conscious, moving-free cynomolgus monkeys (Macaca fascicularis) during circadian, meal, stress and drug exposure. MATERIALS AND METHODS: Blood glucose, body temperature and physical activities were continuously and simultaneously recorded by implanted HD-XG telemetry device for up to 10 weeks...
April 1, 2017: Journal of Endocrinological Investigation
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