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Journal of Endocrinological Investigation

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https://www.readbyqxmd.com/read/30519958/bone-turnover-markers-bmd-and-tbs-after-short-term-high-dose-glucocorticoid-therapy-in-patients-with-graves-orbitopathy-a-small-prospective-pilot-study
#1
S Censi, J Manso, G Pandolfo, G Franceschet, E Cavedon, Y H Zhu, S Carducci, W Gomiero, M Plebani, M Zaninotto, S Watutantrige-Fernando, C Mian, V Camozzi
PURPOSE: Chronic GC administration has numerous side effects, but little is known about the side effects of their short-term use (< 3 months)-particularly, when high doses are involved, as in the treatment of Graves' orbitopathy (GO). We investigated the effects of short-term, high-dose GC on bone turnover markers, bone mineral density (BMD), and trabecular bone scores (TBS). METHODS: Eleven patients (10 females and 1 male; median age 56 years) with active GO who were candidates for treatment with intravenous (iv) methylprednisone were consecutively enrolled...
December 5, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30499012/incidence-of-y-chromosome-microdeletions-in-patients-with-klinefelter-syndrome
#2
F Sciarra, M Pelloni, F Faja, F Pallotti, G Martino, A F Radicioni, A Lenzi, F Lombardo, D Paoli
PURPOSE: The aim of this study was to study the incidence of Y chromosome microdeletions in a Caucasian population of Klinefelter syndrome (KS) patients and to investigate the possible association between Y chromosome microdeletions and KS. MATERIALS AND METHODS: We conducted a retrospective study on 118 KS patients, 429 patients with non-obstructive azoospermia (NOA), and 155 normozoospermic men. Eight of the 118 KS patients had undergone testicular sperm extraction (TESE)...
November 29, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30488289/gstp1-gene-methylation-and-ahr-rs2066853-variant-predict-resistance-to-first-generation-somatostatin-analogs-in-patients-with-acromegaly
#3
F Ferraù, P D Romeo, S Puglisi, M Ragonese, F Spagnolo, C Salpietro, R Ientile, M Currò, G Visalli, A Alibrandi, I A M Picerno, S Cannavò
PURPOSE: Biomarkers of clinical and therapeutic outcome in acromegaly are needed. Polymorphisms or epigenetic changes of detoxification genes, such as those coding for the aryl hydrocarbon receptor (AHR) and the glutathione-S-transferase-P1 (GSTP1), could have a role in GH secreting pituitary tumors' pathophysiology and clinical expression. In this study, we assessed the contribution of GSTP1 gene promoter methylation status, per se or in combination with the occurrence of the AHR gene rs2066853 variant, on clinical features and response to somatostatin analogs (SSA) treatment in acromegaly patients...
November 28, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30478740/cadmium-exposure-alters-steroid-receptors-and-proinflammatory-cytokine-levels-in-endothelial-cells-in-vitro-a-potential-mechanism-of-endocrine-disruptor-atherogenic-effect
#4
S Fittipaldi, V M Bimonte, A Soricelli, A Aversa, A Lenzi, E A Greco, S Migliaccio
BACKGROUND: Cadmium (Cd) is a widespread environmental pollutant that causes alterations in human health acting as endocrine disruptor. Recent data suggest that cardiovascular system might be a contamination target tissue, since Cd is found in atheromatic plaques. Thus, the purpose of this study was to evaluate the consequence of Cd exposure of endothelial cells in vitro to evaluate detrimental effect in vascular system by a potential sex-steroid hormone receptor-dependent mechanism(s)...
November 26, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30474798/periostin-concentrations-in-childhood-onset-craniopharyngioma-patients
#5
K Heinks, C De Schutter-Nüsse, S Boekhoff, A Bogusz, J Zhu, J Peng, H L Müller
PURPOSE: Periostin is highly expressed in craniopharyngioma (CP)-associated fibroblasts and has been identified as a marker for non-alcoholic fatty liver disease (NAFLD). Half of CP patients with hypothalamic syndrome develop NAFLD. We hypothesized that periostin concentration is elevated in biological fluids of CP and associated with pathological hepatic parameters, indicating increased risk for NAFLD. METHODS: A cross-sectional study on 35 patients with sellar masses (SMP) recruited in the German Childhood Craniopharyngioma Registry (32 CP, 2 xanthogranuloma, 1 pilocytic astrocytoma), three short-statured patients with isolated growth hormone deficiency, five short-statured patients with normal findings in GH-stimulating tests and decreased insulin-like growth factor (IGF)-1 and seven healthy controls...
November 24, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30471004/endocrine-and-metabolic-adverse-effects-of-immune-checkpoint-inhibitors-an-overview-what-endocrinologists-should-know
#6
REVIEW
R M Ruggeri, A Campennì, G Giuffrida, P Trimboli, L Giovanella, F Trimarchi, S Cannavò
Immune checkpoint inhibitors (ICIs) are novel anticancer agents, recently introduced with the aim of boosting the immune response against tumors. ICIs are monoclonal autoantibodies that specifically target inhibitory receptors on T cells: cytotoxic T lymphocyte antigen 4 (CTLA4), programmed death 1 (PD-1) and its ligand (PD-1L). ICIs also generate peculiar dysimmune toxicities, called immune-related adverse events (irAEs), that can potentially affect any tissue, and some may be life-threatening if not promptly recognized...
November 23, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30465249/association-of-serum-ghrelin-with-weight-gain-during-pregnancy-in-overweight-and-normal-women
#7
N Tehranian, M Hosseini, F Ramezani-Tehrani, S Yousefi
PURPOSE: Despite the fact that the ghrelin hormone plays pivotal role in the process of weight gain, its correlation with weighing during pregnancy has not been elucidated. Hence, the present study was conducted to evaluate the correlation between plasma ghrelin levels and gestational weight gain in overweight and normal women. METHODS: This prospective cohort study was conducted in 27 overweight and 18 normal body mass index (BMI) pregnant women referring to Tehran health care centers...
November 21, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30465248/type-2-diabetes-treatment-and-progression-of-chronic-kidney-disease-in-italian-family-practice
#8
G Ermini, C Tosetti, D Zocchi, M Mandreoli, M T Caletti, G Marchesini
AIMS: Progressive chronic kidney disease represents a dreadful complication of type 2 diabetes mellitus (T2DM). We tested the pattern of use and the renal effects of old glucose-lowering drugs in T2DM patients cared for by Italian general practitioners (GPs). METHODS: Data of 2606 T2DM patients were extracted from the databases of GPs, who do not have access to the most recent glucose-lowering drugs in Italy. The rate of kidney function decline was calculated by CKD-EPIcr , based on two consecutive creatinine values...
November 21, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30465247/evaluation-of-body-composition-using-dual-energy-x-ray-absorptiometry-in-patients-with-non-functioning-adrenal-incidentalomas-and-an-intermediate-phenotype-is-there-an-association-with-metabolic-syndrome
#9
A B Moraes, E M R Cavalari, M P de Paula, M Arruda, D S C Curi, R A Leitão, L M C de Mendonça, M L F Farias, M Madeira, L Vieira Neto
PURPOSE: Metabolic syndrome (MS) and sarcopenia are associated with increased cardiovascular risk. No studies using dual-energy x-ray absorptiometry (DXA) have evaluated association between body composition (BC) changes and MS in adrenal incidentaloma (AI). Our aim was to analyse BC in non-functioning AI (NFAI) and intermediate phenotype (IP) relative to controls and to correlate with cortisol levels. METHODS: Cross-sectional study with 44 NFAI (serum cortisol ≤ 50 nmol/L after the overnight 1 mg dexamethasone suppression test), 27 IP (cortisol 51-138 nmol/L), and 41 controls (normal adrenal on imaging examination) using DXA...
November 21, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30456624/physical-activity-in-women-with-subclinical-hypothyroidism
#10
A Tanriverdi, B Ozcan Kahraman, I Ozsoy, F Bayraktar, B Ozgen Saydam, S Acar, E Ozpelit, B Akdeniz, S Savci
PURPOSE: Physical activity is associated with many health-related benefits. However, there is a shift towards inactive lifestyles around the world. Subclinical hypothyroidism (SCH) may have adverse effects similar to hypothyroidism. The presence of symptoms and reduced physical performance in SCH may contribute to an inactive lifestyle. Therefore, the present study aimed to compare physical activity levels (PALs) between women with subclinical hypothyroidism and healthy controls. METHODS: Thirty-two women with newly diagnosed SCH and 28 healthy women were enrolled in this cross-sectional study...
November 19, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30456623/consensus-statement-on-the-use-of-hrt-in-postmenopausal-women-in-the-management-of-osteoporosis-by-sie-siommms-and-sigo
#11
L Vignozzi, N Malavolta, P Villa, G Mangili, S Migliaccio, S Lello
No abstract text is available yet for this article.
November 19, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30443857/the-italian-registry-of-gh-treatment-electronic-clinical-report-form-e-crf-and-web-based-platform-for-the-national-database-of-gh-prescriptions
#12
F Pricci, M Villa, F Maccari, E Agazio, D Rotondi, P Panei, P Roazzi
BACKGROUND: In Italy, the utilization and the reimbursement of Growth Hormone (rGH) therapy by the National Health System (Servizio Sanitario Nazionale) are regulated by the "Note #39" included in the "Notes for the use of drugs" by the Italian Medicines Agency (AIFA), which are published in the Official Gazette, thus having the force of law. The "Note #39" establishes the diagnosis for which the reimbursement is granted and confirms the assignment of the national health surveillance on the use of GH therapy to the Italian National Institute of Health, requesting its computerization...
November 15, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30443856/ultrasound-based-detection-of-glucocorticoid-induced-impairments-of-muscle-mass-and-structure-in-cushing-s-disease
#13
M A Minetto, C Caresio, M Salvi, V D'Angelo, N E Gorji, F Molinari, G Arnaldi, S Kesari, E Arvat
PURPOSE: To investigate the glucocorticoid-induced impairments of muscle mass and structure in patients presenting different stages of steroid myopathy progression. METHODS: Thirty-three patients (28 women) affected by active (N = 20) and remitted (N = 13) Cushing's disease were recruited and the following variables were assessed: walking speed, handgrip strength, total body and appendicular muscle mass by bioelectrical impedance analysis (BIA), thickness and echo intensity of lower limb muscles by ultrasonography...
November 15, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30415310/the-phosphodiesterase-5-inhibitor-sildenafil-decreases-the-proinflammatory-chemokine-il-8-in-diabetic-cardiomyopathy-in-vivo-and-in-vitro-evidence
#14
S Giannattasio, C Corinaldesi, M Colletti, L Di Luigi, C Antinozzi, T Filardi, S Scolletta, S Basili, A Lenzi, S Morano, C Crescioli
PURPOSE: Interleukin (IL)-8 is a proinflammatory C-X-C chemokine involved in inflammation underling cardiac diseases, primary or in comorbid condition, such diabetic cardiomyopathy (DCM). The phosphodiesterase type 5 inhibitor sildenafil can ameliorate cardiac conditions by counteracting inflammation. The study aim is to evaluate the effect of sildenafil on serum IL-8 in DCM subjects vs. placebo, and on IL-8 release in human endothelial cells (Hfaec) and peripheral blood mononuclear cells (PBMC) under inflammatory stimuli...
November 10, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30413979/characteristics-and-follow-up-of-13-pedigrees-with-gitelman-syndrome
#15
F Zhong, H Ying, W Jia, X Zhou, H Zhang, Q Guan, J Xu, L Fang, J Zhao, C Xu
CONTEXT: Gitelman syndrome (GS) is clinically heterogeneous. The genotype and phenotype correlation has not been well established. Though the long-term prognosis is considered to be favorable, hypokalemia is difficult to cure. OBJECTIVE: To analyze the clinical and genetic characteristics and treatment of all members of 13 GS pedigrees. METHODS: Thirteen pedigrees (86 members, 17 GS patients) were enrolled. Symptoms and management, laboratory findings, and genotype-phenotype associations among all the members were analyzed...
November 10, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30406929/autoimmune-thyroid-diseases-are-more-common-in-patients-with-prolactinomas-a-retrospective-case-control-study-in-an-italian-cohort
#16
T Pilli, S Cardinale, C Dalmiglio, C Secchi, N Fralassi, G Cevenini, G Di Cairano, F Maino, R Forleo, F Pacini, M G Castagna
BACKGROUND: Prolactin may exert immunological effects. Over the years, a higher prevalence of autoimmune thyroid diseases (ATD) has been reported in patients with prolactinomas (PRLs) in areas with sufficient iodine intake. PURPOSE: The aim of our study was to evaluate the prevalence of ATD [Graves' disease (GD) and chronic autoimmune thyroiditis (AIT)] in a retrospective cohort of Italian patients with PRLs compared to a sex-matched control group, represented by subjects with non-functioning pituitary adenoma (NFPA) or empty sella (ES)...
November 8, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30406928/identification-a-novel-insertion-phex-mutation-in-a-sporadic-patient-with-hypophosphatemic-rickets
#17
LETTER
P Jin, L H Wang, Z H Mo
No abstract text is available yet for this article.
November 8, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30406378/evaluating-the-effects-of-mobile-health-intervention-on-weight-management-glycemic-control-and-pregnancy-outcomes-in-patients-with-gestational-diabetes-mellitus
#18
H Guo, Y Zhang, P Li, P Zhou, L-M Chen, S-Y Li
PURPOSE: To explore the effects of mobile health (mHealth) intervention on pregnancy weight management, blood glucose control and pregnancy outcomes. METHODS: A total of 124 patients with gestational diabetes mellitus (GDM) were selected. Patients were randomly divided into two groups. The 60 patients in the control group received standard outpatient treatment, while the remaining 64 patients received a nurse's online guidance both through a mobile medical App installed on their phone and through regular offline clinical treatment in the mHealth group...
November 7, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30406377/gender-difference-and-correlation-between-sexuality-thyroid-hormones-cognitive-and-physical-functions-in-elderly-fit
#19
G P Emerenziani, G Izzo, M G Vaccaro, A Quattrone, A Lenzi, A Aversa
PURPOSE: Sexuality in the elderly is related to psycho-physical well-being. Aim of this study was to analyze the correlation between sexual health, thyroid hormones, cognitive functions, and physical fitness in elderly population. METHODS: Fifty-one fit adults were recruited (age: 71.9 ± 5.3 years, 26 females and 25 males). Sexuality was evaluated using the Changes in Sexual Functioning Questionnaire-short form (CSFQ-14) and the Sexual Attitude Scale (SAS)...
November 7, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30392100/serum-levels-of-adipokines-in-gestational-diabetes-a-systematic-review
#20
REVIEW
I Bellos, G Fitrou, V Pergialiotis, D N Perrea, G Daskalakis
OBJECTIVE: To determine the difference of serum levels of 10 adipokines (apelin, chemerin, fatty acid-binding protein-4, fibroblast growth factor-21, monocyte chemoattractant protein-1, nesfatin-1, omentin-1, resistin, vaspin, and visfatin) among women with gestational diabetes and healthy pregnant controls. MATERIALS AND METHODS: Literature search was conducted using the Medline (1966-2018), Scopus (2004-2018), Cochrane Central Register of Controlled Trials (CENTRAL) (1999-2018), Clinicaltrials...
November 3, 2018: Journal of Endocrinological Investigation
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