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Journal of Endocrinological Investigation

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https://www.readbyqxmd.com/read/29671256/effects-of-growth-hormone-on-pregnancy-rates-of-patients-with-thin-endometrium
#1
N Cui, A-M Li, Z-Y Luo, Z-M Zhao, Y-M Xu, J Zhang, A-M Yang, L-L Wang, G-M Hao, B-L Gao
PURPOSE: To investigate whether growth hormone (GH) could improve pregnancy rates of patients with thin endometrium by clinical study and laboratory experiments. MATERIALS AND METHODS: Ninety-three patients were randomized to either the GH-received group (40) or the routine exogenous administration of estrogens control group (53) for clinical study. The human endometrial carcinoma cell line RL95-2 was used for testing the role of GH with Western blot and real-time PCR by exposure to various concentrations of GH (0...
April 18, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29667113/lack-of-association-between-obesity-and-aggressiveness-of-differentiated-thyroid-cancer
#2
G Grani, L Lamartina, T Montesano, G Ronga, V Maggisano, R Falcone, V Ramundo, L Giacomelli, C Durante, D Russo, M Maranghi
PURPOSE: Aim of this study was to evaluate the association between body mass index (BMI) and aggressive features of differentiated thyroid cancer (DTC) in a prospective cohort. METHODS: Patients with DTC were prospectively enrolled at a tertiary referral center and grouped according to their BMI. Aggressive clinic-pathological features were analyzed following the American Thyroid Association Initial Risk Stratification System score. RESULTS: The cohort was composed of 432 patients: 5 (1...
April 17, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29619749/decreased-staging-of-differentiated-thyroid-cancer-in-patients-with-chronic-lymphocytic-thyroiditis
#3
M Borowczyk, A Janicki, G Dworacki, E Szczepanek-Parulska, M Danieluk, J Barnett, M Antonik, M Kałużna, B Bromińska, R Czepczyński, M Bączyk, K Ziemnicka, M Ruchała
PURPOSE: The biological association between chronic lymphocytic thyroiditis (CLT) and differentiated thyroid cancer (DTC) has not been elucidated yet. The aim of the study was to assess whether the presence of CLT exerts any influence on clinical or histological presentation of DTC. METHODS: Nine hundred and seven consecutive patients with DTC treated in the years 1998-2016 were divided into two groups according to the presence or absence of concomitant CLT. The statistical differences were analysed...
April 4, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29616419/clinical-presentation-and-management-of-patients-with-primary-hyperparathyroidism-in-italy
#4
F Saponaro, F Cetani, A Repaci, U Pagotto, C Cipriani, J Pepe, S Minisola, C Cipri, F Vescini, A Scillitani, A Salcuni, S Palmieri, C Eller-Vainicher, I Chiodini, B Madeo, E Kara, E Castellano, G Borretta, L Gianotti, F Romanelli, V Camozzi, A Faggiano, S Corbetta, L Cianferotti, M L Brandi, M L De Feo, A Palermo, G Vezzoli, F Maino, M Scalese, C Marcocci
PURPOSE: Evaluation of the phenotype of primary hyperparathyroidism (PHPT), adherence to International Guidelines for parathyroidectomy (PTx), and rate of surgical cure. METHOD: From January 2014-January 2016, we performed a prospective, multicenter study in patients with newly diagnosed PHPT. Biochemical and instrumental data were collected at baseline and during 1-year follow-up. RESULTS: Over the first year we enrolled 604 patients (age 61 ± 14 years), mostly women (83%), referred for further evaluation and treatment advice...
April 3, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29611050/correction-to-radioiodine-ablation-with-1-850-mbq-in-association-with-rhtsh-in-patients-with-differentiated-thyroid-cancer
#5
Alberto S Tresoldi, Laura F Sburlati, Marcello Rodari, Mink S Schinkelshoek, Michela Perrino, Simone De Leo, Laura Montefusco, Paolo Colombo, Maura Arosio, Andrea Gerardo Antonio Lania, Laura Fugazzola, Arturo Chiti
Unfortunately, the fourth author's middle name was missed out in the original publication of this article. The complete correct name should read as follows.
April 2, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29603098/dna-methylation-of-genes-regulating-appetite-and-prediction-of-weight-loss-after-bariatric-surgery-in-obese-individuals
#6
F Coppedè, M Seghieri, A Stoccoro, E Santini, L Giannini, C Rossi, L Migliore, A Solini
PURPOSE: Epigenetic traits are influenced by clinical variables; interaction between DNA methylation (DNAmeth) and bariatric surgery-induced weight loss has been scarcely explored. We investigated whether DNAmeth of genes encoding for molecules/hormones regulating appetite, food intake or obesity could predict successful weight outcome following Roux-en-Y gastric bypass (RYGB). METHODS: Forty-five obese individuals with no known comorbidities were stratified accordingly to weight decrease one-year after RYGB (excess weight loss, EWL ≥ 50%: good responders, GR; EWL < 50%: worse responders, WR)...
March 30, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29582344/tsh-evaluation-in-hypothyroid-patients-assuming-liquid-levothyroxine-at-breakfast-or-30-min-before-breakfast
#7
I Pirola, E Gandossi, D Brancato, F Marini, A Cristiano, A Delbarba, B Agosti, M Castellano, C Cappelli
PURPOSE: To compare TSH levels of hypothyroid patients treated with liquid LT4 at breakfast or 30 min before breakfast. PATIENTS AND METHODS: Subjects, aged 18-75 years old, were eligible if they presented hypothyroidism, due to Hashimoto's thyroiditis or after thyroidectomy for proven benign goiter. Seven hundred ninety-eight patients were recruited and enrolled in the study. Thirty-seven subjects withdrew from the trial. A total of 761 patients (mean age 46...
March 26, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29582343/gabriella-morreale-de-escobar-1930-2017
#8
EDITORIAL
F Trimarchi, P Vitti
No abstract text is available yet for this article.
March 26, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29574529/predictors-of-fat-free-mass-loss-1-year-after-laparoscopic-sleeve-gastrectomy
#9
B Guida, M Cataldi, L Busetto, M L Aiello, M Musella, D Capone, S Parolisi, V Policastro, G Ragozini, A Belfiore
PURPOSE: Laparoscopic sleeve gastrectomy (LSG) is one of the most frequently performed bariatric surgery interventions because of its safety and efficacy. Nevertheless, concerns have been raised on its detrimental effect on patient nutritional state that can ultimately lead to the loss of fat-free mass (FFM). There is interest in identifying predictors for the early identification of patients at risk of this highly unwanted adverse because they could benefit of nutritional preventive interventions...
March 24, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29574528/microrna-expression-profile-of-thyroid-nodules-in-fine-needle-aspiration-cytology-a-confirmatory-series
#10
M G Castagna, C Marzocchi, T Pilli, R Forleo, F Pacini, S Cantara
INTRODUCTION: MiRNAs are small endogenous non-coding RNAs implicated with gene expression regulation. Changes in miRNA levels have been reported in thyroid cancer. Fine-needle aspiration cytology (FNAC) is the most reliable tool for differential diagnosis of thyroid nodules. METHODS: We have analyzed 174 FNAC from 168 patients with thyroid nodules for expression levels of 11 miRNAs (miRNA197; -187; -181b-3p; -181b-5p; -224; -181a; 146b; -221; -222; -155 and miRNA183) known to be up-regulated in cancer tissues compared to benign lesions...
March 24, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29564756/oxysterol-species-reliable-markers-of-oxidative-stress-in-diabetes-mellitus
#11
A Samadi, A Gurlek, S N Sendur, S Karahan, F Akbiyik, I Lay
PURPOSE: To assess the plasma oxysterol species 7-ketocholesterol (7-Kchol) and cholestane-3β,5α,6β-triol (chol-triol) as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus (DM). METHODS: In total, 26 type 1 and 80 type 2 diabetes patients, along with 205 age- and gender-matched healthy controls, were included in this study. Oxysterols were quantified by liquid chromatography coupled with tandem mass spectrometry and N,N-dimethylglycine derivatization...
March 21, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29560610/investigating-the-effect-of-testosterone-by-itself-and-in-combination-with-letrozole-on-1-25-dihydroxy-vitamin-d-and-fgf23-in-male-rats
#12
F Saki, S R Kasaee, F Sadeghian, F Koohpeyma, G H R Omrani
BACKGROUND: Testosterone deficiency might be associated with vitamin D levels in hypogonadal men, but it is not clear whether testosterone can affect vitamin D and fibroblast growth factor-23 (FGF23), either directly or indirectly via aromatization to estradiol. We aimed to investigate the role of testosterone on vitamin D metabolism and serum FGF23 in male rats. METHODS: A total of 48 male rats were divided into 4 equal groups: sham; O, orchiectomy; O + T, orchiectomized rats treated with testosterone; and O + T + L, orchiectomized rats treated with combination of testosterone and letrozole...
March 20, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29560609/joseph-boruwlaski-the-last-court-dwarf-of-the-history
#13
F Trimarchi
No abstract text is available yet for this article.
March 20, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29550935/clinicopathologic-risk-factors-for-right-paraesophageal-lymph-node-metastasis-in-patients-with-papillary-thyroid-carcinoma
#14
Q A Yu, D K Ma, K P Liu, P Wang, C M Xie, Y H Wu, W J Dai, H C Jiang
OBJECTIVES: To investigate risk factors associated with right paraesophageal lymph node (RPELN) metastasis in patients with papillary thyroid carcinoma (PTC) and to determine the indications for right lymph node dissection. METHODS: Clinicopathologic data from 829 patients (104 men and 725 women) with PTC, operated on by the same thyroid surgery team at the First Affiliated Hospital of Harbin Medical University from January 2013 to May 2017, were analyzed. Overall, 309 patients underwent total thyroidectomy with bilateral lymph node dissection, 488 underwent right thyroid lobe and isthmic resection with right central compartment lymph node dissection, and 32 underwent near-total thyroidectomy (ipsilateral thyroid lobectomy with contralateral near-total lobectomy) with bilateral lymph node dissection...
March 17, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29550934/specificity-of-late-night-salivary-cortisol-measured-by-automated-electrochemiluminescence-immunoassay-for-cushing-s-disease-in-an-obese-population
#15
J Aberle, C Schulze Zur Wiesch, J Flitsch, J Veigel, G Schön, R Jung, F Reining, A Lautenbach, R Rotermund, N Riedel
PURPOSE: Data about the specificity of late-night salivary cortisol (LNSC) in obese subjects are still conflicting. Therefore, with this study, we aimed to evaluate the specificity of LNSC measurement in an obese cohort with or without type 2 diabetes mellitus (T2DM) using an automated electrochemiluminescence immunoassay (ECLIA). METHODS: A total number of 157 patients involving 40 healthy subjects (HS) with BMI < 25 kg/m2 , 83 obese subjects (OS) with BMI ≥ 35 kg/m2 , and 34 histopathologically proven Cushing's disease (CD) were included...
March 17, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29549631/combined-braf-v600e-analysis-and-99m-tc-mibi-scintigraphy-can-be-a-useful-diagnostic-tool-in-differentiated-thyroid-cancer-patients-with-incomplete-bio-chemical-response-to-first-radioiodine-therapy-rait-a-pilot-investigation
#16
A Campennì, R M Ruggeri, M Siracusa, S A Pignata, F Di Mauro, A Vento, F Trimarchi, S Baldari
PURPOSE: The aim of the present study was to evaluate the possible diagnostic role of the combined performance of BRAF mutation analysis and MIBI scintigraphy in papillary thyroid cancer (PTC) patients with incomplete bio-chemical response to first radioiodine therapy (RAIT) performed for thyroid remnant ablation. METHODS: The records of 15 PTC patients with bio-chemical incomplete response to first RAIT were retrospectively analyzed. BRAFV600E analysis on primary tumor samples was obtained in all cases along with neck ultrasonography and99m Tc-MIBI scintigraphy of the neck-thorax regions at first follow-up...
March 16, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29549630/from-inflammation-to-sexual-dysfunctions-a-journey-through-diabetes-obesity-and-metabolic-syndrome
#17
REVIEW
M I Maiorino, G Bellastella, D Giugliano, K Esposito
Metabolic diseases are associated with chronic low-grade inflammation, which has been indicated as a potential mediator of endothelial dysfunction and cardiovascular disease. Visceral adiposity is thought to be the starting condition of the inflammatory state through the release of inflammatory cytokines, including TNF-alpha, CRP, and IL-6, which in turn promote endothelial dysfunction, endothelial expression of chemokines (IL-1) and adhesion molecules (ICAM-1, VCAM-1, and P-selectin), and the inhibition of anti-atherogenic factors (adiponectin)...
March 16, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29549629/lymph-node-location-is-a-risk-factor-for-papillary-thyroid-cancer-related-death
#18
G Sapuppo, M Tavarelli, M Russo, P Malandrino, A Belfiore, R Vigneri, G Pellegriti
PURPOSE: Papillary thyroid cancer (PTC) has good prognosis with a very low chance of mortality. The prognostic role of metastatic lymph node location was judged controversial and more recently (TNM VIII ed.) was considered to have no impact on the prognosis of older patients. The aim of the study was to evaluate the role of metastasized node location on PTC-related mortality. METHODS: PTC-related mortality was analysed in a consecutive retrospective series of 1653 PTC patients followed at our Thyroid Clinic (mean follow-up 5...
March 16, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29546656/association-of-pon1-gene-polymorphisms-with-polycystic-ovarian-syndrome-risk-a-meta-analysis-of-case-control-studies
#19
D Liao, H Yu, L Han, C Zhong, X Ran, D Wang, L Mo
PURPOSE: Evidences showed that paraoxonase 1 (PON1) gene polymorphism has an impact on women's susceptibility to polycystic ovarian syndrome (PCOS) by influencing the expression and activity of PON1. However, the effects of three PON1 polymorphisms (- 108 C>T, L55M and Q192R) on the incidence of PCOS have generated inconsistent results. Here, we conducted a meta-analysis to investigate the association between PON1 polymorphisms and PCOS risk. METHODS: All eligible trials were identified via systematic searches of multiple literature databases...
March 15, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29546655/clinical-impact-of-the-new-siapec-iap-classification-on-the-indeterminate-category-of-thyroid-nodules
#20
C Sparano, G Parenti, A Cilotti, L Bencini, M Calistri, E Mannucci, C Biagini, V Vezzosi, M Mannelli, G Forti, L Petrone
BACKGROUND: The increasing frequency in the diagnosis of thyroid nodules has raised a growing interest in the search for new diagnostic tools to better select patients deserving surgery. In 2014, the major Italian Societies involved in the field drafted a new cytological classification, to better stratify pre-surgical risk of thyroid cancer, especially for the indeterminate category, split into TIR3A and TIR3B subclasses, associated to different therapeutic decisions. MATERIALS AND METHODS: This retrospective cross-sectional survey analyzed thyroid fine-needle aspiration biopsy performed at our outpatient clinic before and after the introduction of the new SIAPEC-IAP consensus in May 2014...
March 15, 2018: Journal of Endocrinological Investigation
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