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Journal of Endocrinological Investigation

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https://www.readbyqxmd.com/read/28822110/the-baptism-of-the-princes-of-marseille-gaudenzio-ferrari-1475-1546
#1
LETTER
E Martino, L Macrì
No abstract text is available yet for this article.
August 18, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28819906/correlation-between-adrenal-function-growth-hormone-secretion-and-insulin-sensitivity-in-children-with-idiopathic-growth-hormone-deficiency
#2
A Ciresi, S Radellini, E Vigneri, V Guarnotta, J Bianco, M G Mineo, C Giordano
PURPOSE: Patients with growth hormone deficiency (GHD) demonstrate an increased cortisol/cortisone ratio which could potentially explain the metabolic features of GHD, while GH treatment (GHT) could increase the cortisol metabolism. METHODS: In 35 children (27 M, mean age 10.1 years) with idiopathic GHD at baseline and after 12 months of GHT and in 25 controls, in addition to metabolic parameters, we assessed adrenal function by morning serum cortisol, its peak, and its area under the curve (AUCCOR) during insulin tolerance test (ITT)...
August 18, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28819917/polyglandular-autoimmune-syndromes
#3
REVIEW
G J Kahaly, L Frommer
BACKGROUND: In recent years, scientific knowledge pertaining to the rare ORPHAN polyglandular autoimmune syndrome (registered code ORPHA 282196) has accumulated. OBJECTIVE: To offer current demographic, clinical, serological and immunogenic data on PAS. METHODS: Review of the pertinent and current literature. RESULTS: Polyglandular autoimmune syndromes (PAS) are multifactorial diseases with at least two coexisting autoimmune-mediated endocrinopathies...
August 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28819753/growth-hormone-treatment-improves-final-height-and-nutritional-status-of-children-with-chronic-kidney-disease-and-growth-deceleration
#4
C Bizzarri, A Lonero, M Delvecchio, L Cavallo, M F Faienza, M Giordano, L Dello Strologo, M Cappa
PURPOSE: Growth retardation is a common complication of chronic kidney disease (CKD) in children. Treatment with recombinant human growth hormone (rhGH) has been used to help short children with CKD to attain a height more in keeping with their age group, but the scientific evidence regarding the effect of rhGH on final height is scarce. METHODS: Final heights of children with CKD receiving rhGH treatment (cases) were compared with final heights of a matched cohort of children with CKD that did not receive rhGH therapy (controls)...
August 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28815484/diagnostic-performance-of-a-newly-developed-salivary-cortisol-and-cortisone-measurement-using-an-lc-ms-ms-method-with-simple-and-rapid-sample-preparation
#5
K Mészáros, G Karvaly, Z Márta, B Magda, J Tőke, N Szücs, M Tóth, K Rácz, A Patócs
BACKGROUND: Late-night salivary cortisol level is one of the first-line tests recommended by the Endocrine Society for the diagnosis of endogenous hypercortisolism. Most routine laboratories measure cortisol levels using immunoassay tests which fail to determine low cortisol levels accurately due to the numerous interfering substances. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method with simple and rapid sample preparation was developed for the simultaneous measurement of cortisol and cortisone and its performance in the diagnosis of endogenous hypercortisolism was evaluated...
August 16, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28803366/does-hypoglycaemia-affect-the-improvement-in-qol-after-the-transition-to-insulin-in-people-with-type-2-diabetes
#6
T H Wieringa, M de Wit, J W R Twisk, F J Snoek
PURPOSE: Quality of Life (QoL) of insulin-naïve people with type 2 diabetes mellitus (T2DM) improves after transition to insulin. Little is known about the role of hypoglycaemia in this context. Secondary analyses of the Study of the Psychological Impact in Real care of Initiating insulin glargine Treatment (SPIRIT) aimed to investigate the relationship between hypoglycaemia and QoL when transitioning to insulin. METHODS: Insulin-naïve Dutch people with T2DM in suboptimal glycaemic control (HbA1c >53 mmol/mol; 7...
August 12, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28803346/sense-of-coherence-self-esteem-and-health-locus-of-control-in-subjects-with-type-1-diabetes-mellitus-with-without-satisfactory-metabolic-control
#7
C Nuccitelli, A Valentini, M T Caletti, C Caselli, N Mazzella, G Forlani, G Marchesini
BACKGROUND: Despite intensive training, a few individuals with Type 1 diabetes mellitus (T1DM) fail to reach the desired metabolic targets. AIM: To evaluate the association between disease-related emotional and cognitive aspects and metabolic control in subjects with T1DM. SUBJECTS AND METHODS: Health locus of control (HLOC), sense of coherence (SOC), and self-esteem were assessed in T1DM subjects using validated questionnaires. Sixty-seven consecutive subjects who did not attain the desired HbA1c target (mean HbA1c, 8...
August 12, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28795342/effect-of-cholecalciferol-therapy-on-serum-fgf23-in-vitamin-d-deficient-patients-a-randomized-clinical-trial
#8
T Kamelian, F Saki, M Jeddi, M H Dabbaghmanesh, G H R Omrani
INTRODUCTION: Fibroblast growth factor-23 plays an important role in regulating systemic phosphate homeostasis, and vitamin D metabolism. However, the effect of Cholecalciferol therapy on FGF23 serum level in patients with vitamin D deficiency has not been studied, yet. MATERIALS AND METHODS: This is a double-blind, randomized clinical trial on 119 vitamin D deficient patients in 2016. Biochemical variables of treatment and placebo groups were analyzed after 12 weeks of 50,000 IU of Cholecalciferol vs...
August 9, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28770447/the-effect-of-primary-hyperparathyroidism-on-pancreatic-exocrine-function
#9
P Sisman, M Avci, A Akkurt, A B Sahin, O O Gul, C Ersoy, E Erturk
BACKGROUND: Elastase-1 is a proteolytic enzyme secreted by pancreatic acinar cells, and measurements of the concentration this enzyme are used to evaluate pancreatic exocrine function. We aimed to determine whether pancreatic exocrine function declines due to chronic hypercalcemia by measuring fecal elastase levels. METHODS: 75 patients with primary hyperparathyroidism (18 men and 47 women) and 30 healthy subjects (11 men and 19 women) participated in this study...
August 2, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28762013/the-role-of-micrornas-in-different-types-of-thyroid-carcinoma-a-comprehensive-analysis-to-find-new-mirna-supplementary-therapies
#10
REVIEW
S Pishkari, M Paryan, M Hashemi, E Baldini, S Mohammadi-Yeganeh
The most common endocrine malignancy is thyroid cancer, and researchers have made a great deal of progress in deciphering its molecular mechanisms in the recent years. Many of molecular changes observed in thyroid cancer can be used as biomarkers for diagnosis, prognosis, and therapeutic targets for treatment. MicroRNAs (miRNAs) are important parts in biological and metabolic pathways such as regulation of developmental stages, signal transduction, cell maintenance, and differentiation. Therefore, their dysregulation can expose individuals to malignancies...
July 31, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28755102/non-surgical-ablative-therapies-for-inoperable-benign-insulinoma
#11
REVIEW
C Mele, A Brunani, B Damascelli, V Tichà, L Castello, G Aimaretti, M Scacchi, P Marzullo
PURPOSE: Benign insulinoma is the most common functioning neuroendocrine tumor of the pancreas. The gold-standard therapeutic approach for insulinoma is surgery, which allows for tumor removal, histology and immunochemical analyses. If surgery is not feasible, minimally invasive ablative procedures performed by interventional radiology can lead to partial or complete remission of hormone hypersecretion and tumor control in insulinoma patients. METHODS: We performed a review of existing literature on non-chemotherapeutic/radioactive ablative techniques employed for the treatment of benign, otherwise inoperable, pancreatic insulinoma...
July 28, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28752302/jusepe-de-ribera-lo-spagnoletto-sileno-ebbro
#12
LETTER
E Martino
No abstract text is available yet for this article.
July 27, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28752301/gender-differences-in-the-association-of-elmo1-genetic-variants-with-type-2-diabetes-in-tunisian-arabs
#13
A Turki, S Mzoughi, N Mtitaoui, M Khairallah, H Marmouch, S Hammami, T Mahjoub, W Y Almawi
PURPOSE: Polymorphisms of the engulfment and cell motility 1 (ELMO1) gene were recently associated with type 2 diabetes (T2DM) and its complications. We investigated the association of rs10255208, rs7782979, and rs2041801 ELMO1 gene variants with T2DM in Tunisian Arabs. METHODS: Subjects comprised 900 T2DM patients and 600 normoglycemic controls. ELMO1 genotyping was done by PCR-RFLP; the contribution of ELMO1 variants to T2DM was analyzed by Haploview and regression analysis...
July 27, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28741280/energy-expenditure-in-the-etiology-of-human-obesity-spendthrift-and-thrifty-metabolic-phenotypes-and-energy-sensing-mechanisms
#14
REVIEW
P Piaggi, K L Vinales, A Basolo, F Santini, J Krakoff
The pathogenesis of human obesity is the result of dysregulation of the reciprocal relationship between food intake and energy expenditure (EE), which influences daily energy balance and ultimately leads to weight gain. According to principles of energy homeostasis, a relatively lower EE in a setting of energy balance may lead to weight gain; however, results from different study groups are contradictory and indicate a complex interaction between EE and food intake which may differentially influence weight change in humans...
July 24, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28733963/peroxisome-proliferator-activated-receptor-gamma-expression-in-peripheral-blood-mononuclear-cells-and-angiopoietin-like-protein-4-levels-in-obese-children-and-adolescents
#15
Z A Sadeghabadi, M Nourbakhsh, M Alaee, B Larijani, M Razzaghy-Azar
PURPOSE: The peroxisome proliferator-activated receptor γ (PPARγ) is highly expressed in adipose tissue and functions as transcriptional regulator of metabolism and adipocyte differentiation. Angiopoietin-like protein 4 (ANGPTL4), a central player in various aspects of energy homoeostasis, is induced by PPARγ. The aim of this study was to evaluate ANGPTL4 plasma levels and PPARγ gene expression in peripheral blood mononuclear cells (PBMCs) of children and adolescents with obesity and their association with metabolic parameters...
July 21, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28730425/at-101-acts-as-anti-proliferative-and-hormone-suppressive-agent-in-mouse-pituitary-corticotroph-tumor-cells
#16
B S Yurekli, B Karaca, A Kisim, E Bozkurt, H Atmaca, S Cetinkalp, G Ozgen, C Yilmaz, S Uzunoglu, R Uslu, F Saygili
PURPOSE: Gossypol, a naturally occurring compound in cottonseeds, has anticancer effects against several tumor cell lines. It has been extensively studied in clinical trials and is well tolerated with a favorable safety profile. AT-101, a derivative of R (-)-gossypol, binds to Bcl-2 family proteins and induces apoptosis in vitro. Although transsphenoidal surgical excision of the pituitary corticotroph adenoma is the gold standard of care, it is not successful all the time. Medical therapy for Cushing's disease still remains a challenge for the clinicians...
July 20, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28721522/acquired-partial-lipodystrophy-after-bone-marrow-transplant-during-childhood-a-novel-syndrome-to-be-added-to-the-disease-classification-list
#17
LETTER
G Ceccarini, F Ferrari, F Santini
No abstract text is available yet for this article.
July 18, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28711970/does-a-male-polycystic-ovarian-syndrome-equivalent-exist
#18
REVIEW
R Cannarella, R A Condorelli, L M Mongioì, S La Vignera, A E Calogero
The occurrence of a genetic background in the etiology of polycystic ovarian syndrome (PCOS) represents the rational basis to postulate the existence of a male PCOS equivalent. Hormonal and metabolic abnormalities have been described in male relatives of women with PCOS. These males also have a higher prevalence of early onset (<35 years) androgenetic alopecia (AGA). Hence, this feature has been proposed as a clinical sign of the male PCOS equivalent. Clinical evidence has shown that men with early onset AGA have hormonal and metabolic abnormalities...
July 15, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28711969/hyperuricemia-is-associated-with-an-increased-prevalence-of-paroxysmal-atrial-fibrillation-in-patients-with-type-2-diabetes-referred-for-clinically-indicated-24-h-holter-monitoring
#19
A Mantovani, R Rigolon, A Civettini, B Bolzan, G Morani, S Bonapace, C Dugo, G Zoppini, E Bonora, G Targher
PURPOSE: Several studies have reported an association between hyperuricemia and increased risk of permanent atrial fibrillation (AF) in patients with and without type 2 diabetes mellitus (T2DM). Currently, no published data are available on the relationship between hyperuricemia and risk of paroxysmal AF. METHODS: We retrospectively evaluated 245 T2DM outpatients without pre-existing AF, cancer, cirrhosis and end-stage renal disease, who underwent a 24-h ECG-Holter monitoring for various clinical indications...
July 15, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28695484/use-of-testosterone-gel-compared-to-intramuscular-formulation-for-puberty-induction-in-males-with-constitutional-delay-of-growth-and-puberty-a-preliminary-study
#20
Laura Chioma, Giulia Papucci, Danilo Fintini, Marco Cappa
PURPOSE: Constitutional delay of growth and puberty (CDGP) treatment include observation or therapy with intramuscular testosterone (IMTT). No data are available about transdermal testosterone gel (TTG). The aim of our study was to analyze the use of TTG in males with CDGP. METHODS: 73 boys with CDGP were divided into three groups: IMTT treated with 50 mg i.m. testosterone; TTG with 10 mg daily 2% testosterone transdermal gel, and no treatment (CNT). All subjects were observed at baseline and after 6 months...
July 10, 2017: Journal of Endocrinological Investigation
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