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Journal of Endocrinological Investigation

D Isiklar Ozberk, R Kutlu, I Kilinc, A O Kilicaslan
PURPOSE: To investigate whether mandatory use of iodized salt in Turkey, since 1999 has sufficient effects on pregnant women and their newborns' urinary iodine concentrations (UIC), maternal and newborns' thyroid function tests and breast milk iodine concentrations (BMIC). METHODS: This cross-sectional analytical-type study was conducted in an obstetrics and gynecology hospital in Konya, Turkey. One hundred and seven pregnant women and their 107 full-term newborns were included into the study...
August 11, 2018: Journal of Endocrinological Investigation
R Palui, J Sahoo, S Kamalanathan, S S Kar, S Selvarajan, H Durgia
CONTEXT: The primary treatment of choice for Cushing's disease (CD) is the removal of the pituitary adenoma by transsphenoidal surgery (TSS). The surgical failure is seen in up to 75% of cases depending on the experience of the surgeon in different studies. Medical therapy is one of the options for the treatment of recurrent or persistent CD. METHODOLOGY: The primary outcome of this meta-analysis was to find the proportion of patients achieving normalisation of 24-h urinary free cortisol (remission of CD) following cabergoline monotherapy...
August 10, 2018: Journal of Endocrinological Investigation
R Reale, A Tumminia, L Romeo, N La Spina, R Baratta, G Padova, L Tomaselli, L Frittitta
PURPOSE: The aim of this randomized study was to examine the efficacy of two high intensity educational programs: the conversation maps-based (CM™) education and the individual education (IE), compared to usual care (UC) in a cohort of type 2 diabetic (T2DM) patients. METHODS: Ninety T2DM outpatients (30 per group) were randomized and 79 finished the study and were analyzed. The CM™ and IE groups received four educational sessions at 0, 4, 8 and 12 weeks, while the UC group received two brief individual sessions at 0 and 12 weeks...
August 10, 2018: Journal of Endocrinological Investigation
M A Riva, M Belingheri
No abstract text is available yet for this article.
August 9, 2018: Journal of Endocrinological Investigation
F Trimarchi, E A Jannini
No abstract text is available yet for this article.
August 9, 2018: Journal of Endocrinological Investigation
I Bossert, S Chytiris, M Hodolic, L Croce, L Mansi, L Chiovato, G Mariani, G Trifirò
PURPOSE: Identification of pathologic parathyroid glands in primary hyperparathyroidism, traditionally based on neck ultrasound (US) and/or 99m Tc-Sestamibi scintigraphy, can be challenging. PET/CT with 18 F-Fluorocholine (18 F-FCH) might improve the detection of pathologic parathyroid glands. We aimed at comparing the diagnostic performance of 18 F-FCH-PET/CT with that of dual-phase dual-isotope parathyroid scintigraphy and neck US. METHODS: Thirty-four consecutive patients with primary hyperparathyroidism were prospectively enrolled, 7 had normocalcemic hyperparathyroidism, and 27 had classic hypercalcemic hyperparathyroidism...
August 9, 2018: Journal of Endocrinological Investigation
M Caputo, A Ucciero, C Mele, L De Marchi, C Magnani, T Cena, P Marzullo, F Barone-Adesi, G Aimaretti
PURPOSE: Recent studies from national registries have described changing patterns in epidemiology of acromegaly. Our retrospective study used administrative databases to estimate prevalence and incidence of acromegaly in the Piedmont Region, Italy. METHODS: This study was conducted in Piedmont between 2012 and 2016 on administrative health databases for inpatients and outpatients of any age. Enrollees were included if claims suggestive of acromegaly were identified in at least two of the following databases: Drug Claims Registry, Hospital Information System, Co-payment Exemption Registry and Outpatient Specialist Service Information System...
August 1, 2018: Journal of Endocrinological Investigation
M Fernández, A Pereira, C Corvalán, V Mericq
PURPOSE: Puberty onset exhibits remarkable inter-individual and ethnic differences. 5% of Chileans are indigenous but puberty ethnic disparities have not been studied. We aim for evaluating precocious puberty prevalence in children with Mapuche ancestry vs non-indigenous Chilean children (according to their surnames). METHODS: Longitudinal cohort study: 1003 children (50.2% girls) participating in the Growth and Obesity Chilean Cohort Study (GOCS) were studied. Annual anthropometry was measured since 4-7 years...
July 25, 2018: Journal of Endocrinological Investigation
B M Bonora, A Avogaro, G P Fadini
BACKGROUND: Good glycaemic control during pregnancy is key to reduce maternal and foetal complications. Insulin degludec, an ultralong acting analogue with a "peakless" and stable pharmacokinetic profile, has the potential advantage of reducing hypoglycaemia and glucose variability compared to other basal insulins. Therefore, degludec could be a reasonable therapeutic option for pregnant women with type 1 diabetes (T1D). However, degludec is not licensed for use during pregnancy owing to the lack of safety data...
July 24, 2018: Journal of Endocrinological Investigation
F J Salge-Arrieta, R Carrasco-Moro, V Rodríguez-Berrocal, H Pian, J S Martínez-San Millán, P Iglesias, L Ley-Urzáiz
BACKGROUND: Pituicytomas (PTs) are extremely rare, low-grade glial tumors closely related to the neurohypophyseal axis. Definite conclusions concerning the optimal diagnostic and therapeutic approach to these neoplasms are lacking to date, as most of this information has been presented as case reports. METHODS: Retrospective review of case reports published in the scientific literature to date, including a new illustrative example treated in our department. RESULTS: 116 cases were collected...
July 20, 2018: Journal of Endocrinological Investigation
Z Heidar, M Bakhtiyari, F Foroozanfard, M Mirzamoradi
Unfortunately, the first author name was incorrectly published in the original publication. The complete correct name should read as follows.
July 20, 2018: Journal of Endocrinological Investigation
S Palmieri, M F Bedeschi, E Cairoli, V Morelli, M E Lunati, A Scillitani, V Carnevale, F Lalatta, A M Barbieri, E Orsi, A Spada, I Chiodini, C Eller-Vainicher
CONTEXT: The previous studies suggested a possible increased risk of hypercalcaemia and reduced bone mineral density (BMD) in Williams' syndrome (WS). However, an extensive study regarding bone metabolism has never been performed. OBJECTIVE: To investigate bone health in young adults with WS. DESIGN: Cross-sectional study. SETTINGS: Endocrinology and Metabolic Diseases and Medical Genetic Units. PATIENTS: 29 WS young adults and 29 age- and sex-matched controls...
July 20, 2018: Journal of Endocrinological Investigation
K Zhang, C Li, J Liu, X Tang, Z Li
BACKGROUND: Thyroid cancer is one of the most common endocrine malignancies. Although the 10-year survival rate of differentiated thyroid cancer (DTC) is about 90% after conventional treatments, a small proportion of patients still suffer from tumor recurrence or drug resistance. OBJECTIVE: This review article summarizes recent researches and clinical trials related to target drugs that reduce mortality in thyroid cancer. METHODS: This is a review of the recent literature and clinical trials on the three main aspects including methylation genes in thyroid cancers, the relationship between BRAF mutation and gene methylation, target and dehypermethylation drugs in clinical trials...
July 10, 2018: Journal of Endocrinological Investigation
F Ceccato, G Marcelli, M Martino, C Concettoni, M Brugia, L Trementino, G Michetti, G Arnaldi
INTRODUCTION AND AIM: A prompt diagnosis of Cushing's Syndrome (CS) in high-risk populations is mandatory: 1-mg dexamethasone suppression test (1-mg DST), late night salivary cortisol (LNSC), and urinary-free cortisol (UFC) are recommended, despite thresholds calculated in retrospective studies. Our aim was to study the diagnostic accuracy of LNSC measured with chemiluminescence assay in a prospective study, confirming discrepancies with mass spectrometry (MS). MATERIALS AND METHODS: We enrolled 117 controls and 164 suspected CS (CS = 47, non-CS = 117)...
July 9, 2018: Journal of Endocrinological Investigation
C Lualdi, A Silverii, I Dicembrini, L Pala, M Monami, E Mannucci
BACKGROUND: Degludec is a long-acting insulin with a longer duration of action and a greater day-to-day reproducibility of absorption in comparison with previous long-acting insulin formulations. The aim is the definition of the change in insulin needs in patients switching from detemir/glargine to degludec in real-life conditions. METHODS: In this retrospective cohort observational study, all outpatients with either type 1 or type 2 diabetes, starting therapy with degludec insulin-after a prior treatment with either detemir or glargine insulin for at least 6 months-were included...
July 9, 2018: Journal of Endocrinological Investigation
J Simões-Pereira, M M Moura, I J Marques, M Rito, R A Cabrera, V Leite, B M Cavaco
PURPOSE: The EIF1AX gene was recently described as a new thyroid cancer-related gene. Its mutations were mainly reported in poorly differentiated (PDTC) and anaplastic thyroid cancers (ATC), but also in well-differentiated thyroid cancer (WDTC) and in benign thyroid lesions, although less frequently. Our aim was to address whether EIF1AX mutations are present in the different stages of thyroid tumourigenesis (from hyperplasia to well-differentiated and to poorly differentiated/undifferentiated lesions), and to clarify its role in this process...
July 2, 2018: Journal of Endocrinological Investigation
M Bicer, M Alan, P Alarslan, A Guler, G U Kocabas, C Imamoglu, M Aksit, G Bozkaya, A M Isil, A Baloglu, B Aslanipoiur, Mehmet Calan
PURPOSE: Insulin-like peptide 5 (INSL5) is a gut peptide hormone that is a member of relaxin/insulin superfamily. Growing evidence implicates the crucial role of the peptide in some metabolisms including food intake, glucose homeostasis and reproductive system. Polycystic ovary syndrome (PCOS) is involved in both reproductive and metabolic issues. The aim of the study was determination of circulating levels of INSL5 alteration in women with PCOS and evaluation of the relationship between INSL5 and hormonal-metabolic parameters as well as carotid intima media thickness (cIMT)...
June 28, 2018: Journal of Endocrinological Investigation
E Masiello, G Veronesi, D Gallo, P Premoli, E Bianconi, S Rosetti, C Cusini, J Sabatino, S Ippolito, E Piantanida, M L Tanda, L Chiovato, W M Wiersinga, L Bartalena
BACKGROUND: Antithyroid drugs (ATDs) are first-line treatment for Graves' hyperthyroidism worldwide, but relapses are frequent. The reliability of individual risk factors to predict at baseline subsequent relapse is poor. Predictive scores grouping single risk factors might help to select the best treatment (pharmacological vs. ablative). OBJECTIVE: To assess the predictivity of a recently developed score (Clinical Severity Score, CSS) and to compare it with another score (GREAT score)...
June 26, 2018: Journal of Endocrinological Investigation
R Canipari, C Mangialardo, V Di Paolo, F Alfei, S Ucci, V Russi, M G Santaguida, C Virili, M Segni, S Misiti, M Centanni, C Verga Falzacappa
PURPOSE: Thyroid disorders are clinically associated with impaired fertility in women, and these abnormalities can be improved by restoring the euthyroid state. The exact mechanisms of thyroid effect on female fertility are not well known; however, it is conceivable that thyroid hormones (THs) might act on ovarian physiology via receptors in granulosa cells. This work is aimed at evaluating the effects of THs on non-tumoral granulosa cells and follicles. METHODS: Freshly isolated rat ovarian follicles and granulosa cells were exposed to T3 or T4 (THs)...
June 22, 2018: Journal of Endocrinological Investigation
R Accorona, G Colombo
No abstract text is available yet for this article.
June 22, 2018: Journal of Endocrinological Investigation
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