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Journal of Endocrinological Investigation

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https://www.readbyqxmd.com/read/29450867/20s-proteasome-in-the-blood-plasma-of-boys-with-cryptorchidism
#1
D Toliczenko-Bernatowicz, E Matuszczak, M Tylicka, A Sankiewicz, M Komarowska, E Gorodkiewicz, W Debek, A Hermanowicz
PURPOSE: To evaluate the concentration of 20S proteasome in the blood plasma of boys with cryptorchidism. METHODS: Patients-50 boys aged 1-4 years (median = 2.4 years) with unilateral cryptorchidism. The control group-50 healthy, age-matched boys (aged 1-4 years, median = 2.1 years), admitted for planned herniotomy. In our study, we used a novel technique Surface PLASMON RESONANCE Imaging. RESULTS: The median concentration of 20S proteasome in the blood plasma of boys with cryptorchidism was 2...
February 15, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29450866/rehabilitative-orbital-decompression-for-graves-orbitopathy-results-of-a-randomized-clinical-trial
#2
S Sellari-Franceschini, R Rocchi, M Marinò, A Bajraktari, B Mazzi, G Fiacchini, P Lepri, I Dallan, P Vitti, C Marcocci
PURPOSE: Orbital decompression (OD) is a consolidated procedure for the treatment of exophthalmos in Graves' orbitopathy (GO). The efficacy of the various procedures remains unclear due to the variability of the techniques used. To address this issue, we performed a randomized clinical trial to compare the efficacy of two surgical techniques. The primary endpoint was the reduction in proptosis. Secondary aims were the risk of post-operative diplopia (POD) in primary gaze and other surgical complications...
February 15, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29446011/continuously-sustained-elimination-of-iodine-deficiency-a-quarter-of-a-century-success-in-the-islamic-republic-of-iran
#3
H Delshad, P Mirmiran, Z Abdollahi, F Salehi, F Azizi
BACKGROUND: Iodine deficiency and related disorders were very common in Iran prior to 1996, when universal salt iodization (USI) was implemented and in 2000 Iran was declared iodine deficiency disorders (IDD) free. The aim of this study was to evaluate the adequacy of iodine intake by Iranian households in all 30 provinces of Iran, a quarter of a century after the intervention. METHODS: A total of 18,000 school-aged children (8-10 years with mean 8.7 ± 1 year) were included in this study...
February 14, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29446010/phosphaturic-mesenchymal-tumors-what-an-endocrinologist-should-know
#4
REVIEW
J M Boland, P J Tebben, A L Folpe
Tumor-induced osteomalacia (TIO), also known as "oncogenic osteomalacia", is a rare cause of osteomalacia. TIO often has an insidious onset characterized clinically by progressive muscle weakness and bone pain with fractures. The hallmark biochemical finding is a persistent low serum phosphorus concentration due to renal phosphate wasting. The vast majority of cases of TIO result from production of the phosphaturic hormone fibroblast growth factor 23 (FGF23) by a histologically distinctive mesenchymal tumor, termed "phosphaturic mesenchymal tumor" (PMT)...
February 14, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29441462/up-regulation-of-mir-340-5p-promotes-progression-of-thyroid-cancer-by-inhibiting-bmp4
#5
P Zhao, W Ma, Z Hu, Y Zhang, S Zhang, Y Wang
PURPOSE: The incidence of thyroid cancer is increasing and the proliferation of thyroid cancer cells is incompletely understood. microRNAs may play key roles in thyroid cancer progression. METHODS: We analyzed miR-340-5p in thyroid cancer tissue and normal tissue, and using informatics to predict its target. Cell lines and a mouse model were used to study the role of miR-340-5p in cancer proliferation. RESULTS: Overexpression of miR-340-5p was found in thyroid cancer specimens...
February 13, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29423542/evaluation-of-growth-hormone-response-to-ghrh-plus-arginine-test-in-children-with-idiopathic-short-stature-role-of-peak-time
#6
M Castagno, A Monzani, S Zanetta, G Genoni, E Giglione, R Ricotti, G Bona, F Prodam, S Bellone
PURPOSE: To describe the course of growth hormone response to growth hormone releasing hormone (GHRH) plus arginine provocative test in children with idiopathic short stature (ISS) and to evaluate the role of peak time. METHODS: A retrospective study was performed analyzing 344 GHRH plus arginine provocative tests performed in children and adolescents with short stature. Serum GH levels were measured at four-time points (T0', T30', T45' and T60') and GH peak was defined as the maximum value at any time point...
February 8, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29417469/association-between-systemic-leptin-and-neurotensin-concentration-in-adult-individuals-with-and-without-type-2-diabetes-mellitus
#7
I Barchetta, G Ciccarelli, F A Cimini, V Ceccarelli, M Orho-Melander, O Melander, M G Cavallo
PURPOSE: Leptin is an adipokine which regulates appetite and energy balance through a mechanism partially mediated by neurotensin (NT) in central nervous system. Besides acting as a neurotransmitter, NT is expressed in human intestine where it promotes fat absorption and its circulating levels associate with obesity, type 2 diabetes mellitus (T2DM) and cardiovascular disease. Whether a relation exists between circulating leptin and NT levels has not been investigated yet. The aim of this study was to test the hypothesis of an association between plasma leptin and NT concentration in adults with or without T2DM...
February 7, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29411312/-madonna-of-the-carnation-leonardo-da-vinci-1452-1519
#8
D Lazzeri, P Pozzilli
No abstract text is available yet for this article.
February 6, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29411311/relationship-between-25-hydroxyvitamin-d-and-lipid-profile-in-lebanese-school-children
#9
M H Gannagé-Yared, R Sabbagh, R Chédid
PURPOSE: Limited information is available regarding the association of vitamin D and lipid profile in pediatric populations. The objective of this cross-sectional study is to determine the prevalence of vitamin D deficiency in a large sample of Lebanese schoolchildren and to evaluate the relationship between vitamin D and lipid profile. METHODS: 969 Lebanese schoolchildren (505 boys and 464 girls) aged 8-18 years were recruited from 10 schools of different socioeconomic status (SES)...
February 6, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29404906/a-tuscan-general-with-morbid-obesity
#10
Francesco Trimarchi
No abstract text is available yet for this article.
February 5, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29404905/sir-jeffrey-hudson-the-midget-of-the-queen-henrietta-marie
#11
F Trimarchi, F De Luca
No abstract text is available yet for this article.
February 5, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29396759/multiple-endocrine-neoplasia-2-in-cyprus-evidence-for-a-founder-effect
#12
P Fanis, N Skordis, S Frangos, G Christopoulos, E Spanou-Aristidou, E Andreou, P Manoli, M Mavrommatis, S Nicolaou, M Kleanthous, M A Cariolou, V Christophidou-Anastasiadou, G A Tanteles, L A Phylactou, V Neocleous
PURPOSE: Multiple endocrine neoplasia type 2 (MEN2) affects patients with RET proto-oncogene mutations. This cohort study refers to patients who were diagnosed with familial medullary thyroid carcinoma (MTC) and underwent RET genetic testing in Cyprus between years 2002 and 2017. METHODS AND PATIENTS: Forty patients underwent RET testing by Sanger sequencing of exons 10-11 and 13-16. Genotyping with STR genetic markers flanking the RET gene along with Y-chromosome genotyping and haplogroup assignment was also performed...
February 2, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29396758/insulin-sensitivity-and-secretion-and-adipokine-profile-in-patients-with-cushing-s-disease-treated-with-pasireotide
#13
V Guarnotta, G Pizzolanti, A Ciresi, C Giordano
PURPOSE: To evaluate the effect of pasireotide on β-cell and adipose function in patients with Cushing's disease (CD). METHODS: Clinical and hormonal parameters, insulin secretion evaluated by HOMA-β and by the area under the curve (AUC2h) of C-peptide during a mixed meal tolerance test and insulin sensitivity, evaluated by the euglycaemic hyperinsulinaemic clamp, were evaluated in 12 patients with active CD, before and after 6 and 12 months of pasireotide. In addition, a panel of adipokines including leptin (Ob), leptin/leptin receptor ratio (Ob/Ob-R ratio), adiponectin, resistin, visfatin, adipocyte fatty acid binding protein (AFABP) and non-esterified fatty acids (NEFAs) was evaluated at baseline and after 12 months of pasireotide...
February 2, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29392544/the-use-of-follicle-stimulating-hormone-fsh-for-the-treatment-of-the-infertile-man-position-statement-from-the-italian-society-of-andrology-and-sexual-medicine-siams
#14
A Barbonetti, A E Calogero, G Balercia, A Garolla, C Krausz, S La Vignera, F Lombardo, E A Jannini, M Maggi, A Lenzi, C Foresta, A Ferlin
No abstract text is available yet for this article.
February 1, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29388053/mir15a-and-mir16-in-chilean-type-1-diabetes-patients-possible-association-with-apoptosis-inflammatory-or-autoimmunity-markers
#15
D F Garcia-Diaz, P Camacho-Guillén, E Codner, F Pérez-Bravo
AIM: Type 1 diabetes mellitus (T1D) is an autoimmune disease characterized by the progressive destruction of β cells, mediated by the interaction between T cells and several cytokines. The pathogenesis of T1D has established its possible relationship with miRNAs. In this study, we analyze the expression profile of miR-15a and miR-16 in peripheral blood mononuclear cells (PBMCs) and their possible association with apoptosis, inflammation, or autoimmunity markers. PATIENTS AND METHODOLOGY: 38 T1D patients and 41 control subjects were recruited...
January 31, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29383679/mir15a-and-mir16-in-chilean-type-1-diabetes-patients-possible-association-with-apoptosis-inflammatory-or-autoimmunity-markers
#16
D F Garcia-Diaz, P Camacho-Guillén, E Codner, F Pérez-Bravo
AIM: Type 1 diabetes mellitus (T1D) is an autoimmune disease characterized by the progressive destruction of β cells, mediated by the interaction between T cells and several cytokines. The pathogenesis of T1D has established its possible relationship with miRNAs. In this study, we analyze the expression profile of miR-15a and miR-16 in peripheral blood mononuclear cells (PBMCs) and their possible association with apoptosis, inflammation, or autoimmunity markers. PATIENTS AND METHODOLOGY: 38 T1D patients and 41 control subjects were recruited...
January 30, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29374854/liraglutide-ameliorates-palmitate-induced-insulin-resistance-through-inhibiting-the-irs-1-serine-phosphorylation-in-mouse-skeletal-muscle-cells
#17
Z Li, Y Zhu, C Li, Y Tang, Z Jiang, M Yang, C-L Ni, D Li, L Chen, W Niu
OBJECTIVE: A reduction in insulin-stimulated glucose uptake in skeletal muscles is a characteristic of insulin resistance and type 2 diabetes mellitus (T2DM). The glucagon-like peptide (GLP)-1 agonist liraglutide can reduce blood glucose levels in individuals with T2DM. However, its effect on insulin-induced glucose metabolism in the skeletal muscle of insulin resistance is unknown. We investigated the effects and action mechanisms of liraglutide on insulin resistance (IR) in the skeletal muscle cells treatment with palmitic acid (PA)...
January 27, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29368139/hypertensive-disorders-during-pregnancy-and-3%C3%A2-years-after-delivery-in-women-with-gestational-hyperglycemia
#18
C Festa, L Mattei, O Bitterman, B Pintaudi, M Framarino Dei Malatesta, P Bianchi, M Trappolini, A Colatrella, A Napoli
AIMS: Women with gestational hyperglycemia commonly experience hypertensive disorders during pregnancy. More information is needed about how hypertension develops in these patients over time. We investigated the prevalence of hypertension during and 3 years after pregnancy in Caucasian women with gestational hyperglycemia. We also investigated metabolic syndrome presence, glucose tolerance status, insulin sensitivity and insulin secretion levels in the follow-up period. METHODS: In a prospective longitudinal study with a 3-year follow-up, we assessed hypertension status and clinical-related characteristics of 103 consecutive women with gestational hyperglycemia sub-grouped according to their hypertensive status during and after pregnancy...
January 24, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29363048/association-of-serum-betatrophin-with-fibroblast-growth-factor-21-in-women-with-polycystic-ovary-syndrome
#19
S Kahraman, A E Altinova, M M Yalcin, O Gulbahar, B Arslan, M Akturk, N Cakir, F B Toruner
PURPOSE: Betatrophin and fibroblast growth factor-21 (FGF-21), which are recently discovered members of hepatokine/adipokine family, have been proposed to be associated with some metabolic disorders in which insulin resistance plays a major role. METHODS: We aimed to investigate serum betatrophin and FGF-21 concentrations in women with polycystic ovary syndrome (PCOS). In this cross-sectional study, we recruited 31 women with PCOS and 34 women as healthy controls...
January 23, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29363047/new-perspectives-on-the-definition-and-management-of-polycystic-ovary-syndrome
#20
REVIEW
R Pasquali, A Gambineri
BACKGROUND: There is a growing debate on the opportunity of improving the understanding in the diagnosis and management of polycystic ovary syndrome (PCOS). OBJECTIVE: This review article summarizes recent research related to the definition of polycystic ovary syndrome (PCOS). METHODS: Review of the recent literature on the topic. RESULTS: New ideas on the definition of hyperandrogenism, based on new scientific data and clinical perspectives are presented...
January 23, 2018: Journal of Endocrinological Investigation
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