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Journal of Endocrinological Investigation

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https://www.readbyqxmd.com/read/29222642/pituitary-adenomas-stem-cells-and-cancer-stem-cells-what-s-new
#1
REVIEW
M Caffarini, M Orciani, L Trementino, R Di Primio, G Arnaldi
PURPOSE: To clarify the existence of pituitary stem cells (SCs) both in the embryonic and the postnatal gland and the role for SCs in pituitary adenomas. METHODS: This work, which does not address the pathogenesis of pituitary adenomas, reviews the latest research findings and discoveries on SCs in pituitary and cancer SCs (CSCs) in pituitary adenomas and discusses the involvement of the EMT. RESULTS: Several groups using different approaches and techniques have demonstrated the existence of SCs and CSCs and as they are major players in pituitary adenoma onset...
December 8, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29204916/rnaseh1-gene-variants-are-associated-with-autoimmune-type-1-diabetes-in-colombia
#2
N Pineda-Trujillo, A Rodríguez-Acevedo, A Rodríguez, A Ruíz-Linares, G Bedoya, A Rivera, J-M Alfaro
BACKGROUND: In a previous work, we found linkage and association of type 1 diabetes (T1D) to a 12 known gene region at chromosome 2p25 in Colombian families. Here, we present further work on this candidate region. MATERIALS AND METHODS: Seventeen SNPs located on the 12 candidate genes, in 100 familial trios set, were tested by ARMS-tetraprimer-PCR or PCR-RFLP. Five extra SNPs in the vicinity of rs10186193 were typed. A replica phase included 97 novel familial trios, in whom diabetes-related auto-antibodies (AABs) were tested in sera of the patients...
December 4, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29190000/a-genome-wide-dna-methylation-analysis-in-peripheral-blood-from-patients-identifies-risk-loci-associated-with-graves-orbitopathy
#3
Z Xin, L Hua, T-T Shi, X Tuo, F-Y Yang, Y Li, X Cao, J-K Yang
OBJECTIVE: Graves' orbitopathy (GO) is an inflammatory orbital disease of autoimmune origin with the potential to cause severe functional and psychosocial effects. The pathogenesis has not been fully elucidated. We investigated whether DNA methylation was associated with GO incidence in Chinese patients. MATERIALS AND METHODS: Six GO patients and six age-matched controls were recruited, and genome-wide DNA methylation patterns were analyzed in their peripheral blood...
November 30, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29189999/nafld-nash-in-patients-with-type-2-diabetes-and-related-treatment-options
#4
REVIEW
M G Radaelli, F Martucci, S Perra, S Accornero, G Castoldi, G Lattuada, G Manzoni, G Perseghin
Type 2 diabetes may reduce life expectancy and patients' quality of life due to its micro- and macro-vascular complications and to the higher risk of several types of cancer. An emerging important factor is represented by the hepatic involvement; it is recognized that excessive hepatic fat accumulation represents a typical feature of diabetic patients and that it also plays an important pathogenic role. It is now evident that non-alcoholic fatty liver disease (NAFLD), generally perceived as a benign condition, may have on the contrary an important deleterious impact for diabetic patients increasing the risk to develop cardiovascular complications but also serious hepatic diseases, in particular non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma...
November 30, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29185232/impaired-taste-sensation-in-type-2-diabetic-patients-without-chronic-complications-a-case-control-study
#5
L De Carli, R Gambino, C Lubrano, R Rosato, D Bongiovanni, F Lanfranco, F Broglio, E Ghigo, S Bo
PURPOSE: Few and contradictory data suggest changes in taste perception in type 2 diabetes (T2DM), potentially altering food choices. We, therefore, analyzed taste recognition thresholds in T2DM patients with good metabolic control and free of conditions potentially impacting on taste, compared with age-, body mass index-, and sex-matched normoglycemic controls. METHODS: An ascending-concentration method was used, employing sucrose (sweet), sodium chloride (salty), citric acid (sour), and quinine hydrochloride (bitter), diluted in increasing concentration solutions...
November 28, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29168078/the-effect-of-hypergastrinemia-following-sleeve-gastrectomy-and-pantoprazole-on-type-2-diabetes-mellitus-and-beta-cell-mass-in-goto-kakizaki-rats
#6
E Grong, C Nord, I B Arbo, M Eriksson, B E Kulseng, U Ahlgren, R Mårvik
PURPOSE: Metabolic surgery alters the secretion of gastrointestinal hormones that influence glycemic control. Elevated gastrin has been suggested to benefit patients with type 2 diabetes and has been reported following sleeve gastrectomy in rats. The present study compares the effect of hypergastrinemia following sleeve gastrectomy with proton-pump inhibitor therapy on glycemic control and beta-cell mass in lean, diabetic animals. METHODS: Thirty-three diabetic Goto-Kakizaki rats were randomized into pantoprazole + sham operation (GK-PPI), sleeve gastrectomy (GK-SG) and vehicle + sham operation (GK-V)...
November 22, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29159607/high-resolution-melting-analysis-hrm-for-mutational-screening-of-dnajc17-gene-in-patients-affected-by-thyroid-dysgenesis
#7
I C Nettore, S Desiderio, E De Nisco, V Cacace, L Albano, N Improda, P Ungaro, M Salerno, A Colao, P E Macchia
BACKGROUND: Congenital hypothyroidism is a frequent disease occurring with an incidence of about 1/1500 newborns/year. In about 75% of the cases, CH is caused by alterations in thyroid morphogenesis, defined "thyroid dysgenesis" (TD). TD is generally a sporadic disease but in about 5% of the cases a genetic origin has been demonstrated. Previous studies indicate that Dnajc17 as a candidate modifier gene for hypothyroidism, since it is expressed in the thyroid bud, interacts with NKX2...
November 20, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29152673/approach-to-hyponatremia-according-to-the-clinical-setting-consensus-statement-from-the-italian-society-of-endocrinology-sie-italian-society-of-nephrology-sin-and-italian-association-of-medical-oncology-aiom
#8
E Sbardella, A M Isidori, G Arnaldi, M Arosio, C Barone, A Benso, R Berardi, G Capasso, M Caprio, F Ceccato, G Corona, S Della Casa, L De Nicola, M Faustini-Fustini, E Fiaccadori, L Gesualdo, S Gori, A Lania, G Mantovani, P Menè, G Parenti, C Pinto, R Pivonello, P Razzore, G Regolisti, C Scaroni, F Trepiccione, A Lenzi, A Peri
No abstract text is available yet for this article.
November 20, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29151239/increased-serum-3-carboxy-4-methyl-5-propyl-2-furanpropanoic-acid-cmpf-levels-are-associated-with-glucose-metabolism-in-chinese-pregnant-women
#9
J Yi, H Jin, R Zhang, S Zhang, P Chen, X Yu, X Zhang
PURPOSE: Previous studies have found that 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) was associated with diabetes. This study aimed to investigate the relationship between abnormal increased CMPF levels and gestational diabetes mellitus (GDM). METHODS: We recruited 828 pregnant women, and all of them underwent an oral glucose tolerance test (OGTT). We screened out 141 GDM patients and 230 pregnant women with normal glucose tolerance as controls. The serum CMPF concentration in participants was measured, and the relationship between the serum CMPF concentration and various parameters and biochemical indices was analyzed...
November 18, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29151238/predictability-of-hypoadrenalism-occurrence-and-duration-after-adrenalectomy-for-acth-independent-hypercortisolism
#10
V Morelli, L Minelli, C Eller-Vainicher, S Palmieri, E Cairoli, A Spada, M Arosio, I Chiodini
OBJECTIVE: To evaluate if the parameters of hypothalamic-pituitary-adrenal (HPA) axis activity could predict the occurrence and duration of post-surgical hypocortisolism (PSH) in patients with Cushing's syndrome (CS) and with adrenal incidentaloma (AI). METHODS: We studied 80 patients (54 females, age 53.3 ± 11 years), who underwent adrenalectomy for CS (17 patients) or for AI (53 patients). Before surgery, we measured adrenocorticotroph hormone (ACTH), urinary free cortisol (UFC) and serum cortisol after 1 mg dexamethasone suppression test (1 mg-DST) levels...
November 18, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29150756/impact-of-risk-factors-for-gestational-diabetes-gdm-on-pregnancy-outcomes-in-women-with-gdm
#11
T Filardi, F Tavaglione, M Di Stasio, V Fazio, A Lenzi, S Morano
PURPOSE: In this study, we evaluated the impact of risk factors for gestational diabetes on clinical/biochemical parameters and maternal/fetal outcomes. METHODS: One hundred eighty-three (n 183) women (age 33.8 ± 5.5 years, 59% Caucasians, 41% non-Caucasians) with gestational diabetes were included in the study. Anamnestic information, anthropometric and laboratory parameters, and maternal and fetal outcomes at delivery were collected. RESULTS: Insulin therapy prevalence was higher in Asians vs Caucasians (p = 0...
November 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29147953/impact-of-perfluorochemicals-on-human-health-and-reproduction-a-male-s-perspective
#12
REVIEW
C Foresta, S Tescari, A Di Nisio
Perfluoroalkyl compounds (PFCs) are a class of organic molecules used in industry and consumer products. PFCs are non-biodegradable and bioaccumulate in the environment and for these reasons they have been a major subject of research regarding their toxicity, environmental fate, and sources of human exposure, since they have been shown to induce severe health consequences, such as neonatal mortality, neurotoxicity and immunotoxicity. The aim of this review is to explore the existing knowledge of the interplay between PFCs exposure and human health, with a focus on male reproductive health, given the emerging gender differences in PFCs clearance and their interaction with sex hormones receptors...
November 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29147952/gemigliptin-a-novel-dipeptidyl-peptidase-iv-inhibitor-exerts-a-synergistic-cytotoxicity-with-the-histone-deacetylase-inhibitor-pxd101-in-thyroid-carcinoma-cells
#13
S H Kim, J G Kang, C S Kim, S-H Ihm, M G Choi, H J Yoo, S J Lee
PURPOSE: The influence of the dipeptidyl peptidase-IV inhibitor gemigliptin alone or in combination with the histone deacetylase inhibitor PXD101 on survival of thyroid carcinoma cells was investigated. METHODS: SW1736, TPC-1, 8505C and BCPAP human thyroid carcinoma cells were used. To assess cell survival, cell viability, the percentage of viable cells and dead cells, cytotoxic activity, ATP levels and FACS analysis were measured. To validate the impact of gemigliptin combined with PXD101, the interactions were estimated by obtaining combination index in cells treated with two agents...
November 16, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29134609/expression-of-p27-kip1-and-p18-ink4c-in-human-multiple-endocrine-neoplasia-type-1-related-pancreatic-neuroendocrine-tumors
#14
E B Conemans, G M Raicu-Ionita, C R C Pieterman, K M A Dreijerink, O M Dekkers, A R Hermus, W W de Herder, M L Drent, A N A van der Horst-Schrivers, B Havekes, P H Bisschop, G J Offerhaus, I H M Borel Rinkes, G D Valk, H Th M Timmers, M R Vriens
PURPOSE: Pancreatic neuroendocrine tumors are a major manifestation of multiple endocrine neoplasia type 1 (MEN1). This tumor syndrome is caused by germline mutations in MEN1, encoding menin. Insight into pathogenesis of these tumors might lead to new biomarkers and therapeutic targets for these patients. Several lines of evidence point towards a role for p27(Kip1) and p18(Ink4c) in MEN1-related tumor development in animal models for MEN1, but their contribution to human MEN1-related pancreatic neuroendocrine tumor development is not known...
November 13, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29116583/innovative-clinical-pathways-for-obese-pregnant-women-design-and-feasibility-of-the-padua-project-north-eastern-italy
#15
A Lapolla, D Scibetta, P Gallina, G Iorizzo, M G Dalfrà, S Visentin, G B Nardelli, R Vettor
BACKGROUND: Obesity during pregnancy can adversely affect the wellbeing of the mother and the newborn, as well as the latter's long-term health. Preconception counseling, careful prenatal management, and strict follow-up during pregnancy are, therefore, essential for obese fertile women in order to prevent the negative effects of obesity. METHODS: In this setting, we developed a project that consisted in creating an integrated network of primary, secondary, and tertiary care providers and designing new clinical pathways for managing pregnancy in obese women...
November 7, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29110282/metabolic-benefits-of-1-3-4-o-tolyl-piperazin-1-yl-propyl-pyrrolidin-2-one-a-non-selective-%C3%AE-adrenoceptor-antagonist
#16
Magdalena Kotańska, Katarzyna Kulig, Monika Marcinkowska, Marek Bednarski, Katarzyna Malawska, Paula Zaręba
PURPOSE: Previous studies have shown that several components of the metabolic syndrome, such as hypertension, obesity or imbalanced lipid and carbohydrate homeostasis, are associated with the sympathetic nervous system overactivity. Therefore, the inhibition of the adrenergic nervous system seems to be a reasonable and appropriate therapeutic approach for the treatment of metabolic disturbances. It has been suggested that non-selective adrenoceptor antagonists could be particularly beneficial, since α1-adrenoceptor antagonists can improve disrupted lipid and carbohydrate profiles, while the inhibition of the α2-adrenoceptor may contribute to body weight reduction...
November 7, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29110281/the-effect-of-vitamin-d-supplementation-in-combination-with-low-calorie-diet-on-anthropometric-indices-and-androgen-hormones-in-women-with-polycystic-ovary-syndrome-a-double-blind-randomized-placebo-controlled-trial
#17
S Jafari-Sfidvajani, R Ahangari, M Hozoori, H Mozaffari-Khosravi, H Fallahzadeh, A Nadjarzadeh
PURPOSE: Polycystic ovary syndrome (PCOS) is known as the most common endocrine disorder in reproductive age women. The aim of this studywas to evaluate the effects of vitamin D supplementation in combination with low-calorie diet on anthropometric indices, reproductive hormones and menstrual regularity in overweight and obese PCOS women. METHODS: In this randomized controlled clinical trial, 60 PCOS women with vitamin D insufficiency were randomly assigned to 12 weeks of either (1) weight-loss intervention + 50,000 IU/week oral vitamin D3 or (2) weight-loss intervention + placebo...
November 6, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29103134/androgenic-alopecia-in-a-postmenopausal-sicilian-baroness
#18
G Borzì, F Trimarchi, M Russo
No abstract text is available yet for this article.
November 4, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29103133/recombinant-growth-hormone-therapy-for-prepubertal-children-with-idiopathic-short-stature-in-korea-a-phase-iii-randomized-trial
#19
J Kim, B-K Suh, C W Ko, K-H Lee, C H Shin, J S Hwang, H S Kim, W Y Chung, C J Kim, H-S Han, N Y Kwon, S Y Cho, H-W Yoo, D-K Jin
PURPOSE: Several studies have evaluated the effects of growth hormone (GH) on auxological and biochemical parameters in children with non-GH-deficient, idiopathic short stature (ISS). This study evaluated the efficacy and safety of Growtropin(®)-II (recombinant human GH) in Korean patients with ISS. METHODS: This was a 1-year, open-label, multicenter, phase III randomized trial of Growtropin(®)-II in Korean patients with ISS. In total, 70 prepubertal subjects (39 males, 31 females) between 4 and 12 years of age were included in the study...
November 4, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29101669/25oh-vitamin-d-levels-in-pediatric-patients-affected-by-prader-willi-syndrome
#20
D Fintini, S Pedicelli, S Bocchini, C Bizzarri, G Grugni, M Cappa, A Crinò
PURPOSE: Obesity, insulin resistance, and puberty seem to influence and been inversely associated with 25-hydroxy vitamin D (25OHD) levels. To our knowledge, a study on 25OHD in children and adolescents with Prader-Willi syndrome (PWS), a genetic form of obesity, is not yet available. OBJECTIVE: To analyze the 25OHD values in pediatric PWS subjects in comparison with a control group (CNT), highlighting the possible correlations with IR, BMD, body composition, pubertal stage, and GH therapy (GHT)...
November 3, 2017: Journal of Endocrinological Investigation
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