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Journal of Endocrinological Investigation

X Gong, A Liu, Y Li, H Sun, Y Li, C Li, X Yu, C Fan, Z Shan, W Teng
OBJECTIVES: To explore the effect of isolated maternal hypothyroxinemia (IMH) during the first and second trimester of gestation on pregnancy outcomes. To explore whether levothyroxine (L-T4) treatment of women who had IMH identified in the first trimester improves pregnancy outcomes. METHODS: Women in the early pregnancy in the iodine-sufficient area (n = 3398) were recruited to this prospective cohort study (ChiCTR-TRC-12002326). Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), and thyroid peroxidase antibody (TPOAb) were detected...
October 17, 2018: Journal of Endocrinological Investigation
T Rago, V Cantisani, F Ianni, L Chiovato, R Garberoglio, C Durante, A Frasoldati, S Spiezia, R Farina, G Vallone, A Pontecorvi, P Vitti
Thyroid ultrasonography (US) is the gold standard for thyroid imaging and its widespread use is due to an optimal spatial resolution for superficial anatomic structures, a low cost and the lack of health risks. Thyroid US is a pivotal tool for the diagnosis and follow-up of autoimmune thyroid diseases, for assessing nodule size and echostructure and defining the risk of malignancy in thyroid nodules. The main limitation of US is the poor reproducibility, due to the variable experience of the operators and the different performance and settings of the equipments...
October 16, 2018: Journal of Endocrinological Investigation
E Grossi, F Parisi, P Duca, V M Savasi
BACKGROUND: Pregnancy hormonal milieu represents a crucial determinant of fetal outcome. We aim to determine 17β-estradiol (E2 ) and progesterone (PGT) concentrations in spontaneous pregnancies during the first trimester. In addition, we aim to determine E2 concentrations as a function of gestational age (GA) and PGT. METHODS: Between November 2015 and March 2017, 104 healthy women of at least 18 years undergoing medical consultation for voluntary interruption of pregnancy were enrolled in an observational study at University Hospital ASST Fatebenefratelli Sacco, Milan, Italy...
October 15, 2018: Journal of Endocrinological Investigation
D Giugliano, M I Maiorino, G Bellastella, K Esposito
PURPOSE: Clinical inertia and medication non-adherence are thought to contribute largely to the suboptimal glycemic control in many patients with type 2 diabetes. The present review explores the relations between A1C targets, clinical inertia and medication non-adherence in type 2 diabetes. METHODS: We searched PubMed for English-language studies published from 2001 through June 1, 2018. We also manually searched the references of selected articles, reviews, meta-analyses, and practice guidelines...
October 6, 2018: Journal of Endocrinological Investigation
S Costantino, S Ambrosini, F Paneni
A growing body of evidence suggests that epigenetic modifications-changes to the genome that do not involve changes in DNA sequence-may significantly derail transcriptional programs implicated in angiogenesis, oxidative stress and inflammation, thus fostering cardiovascular damage in patients with diabetes. Notably, adverse epigenetic signals acquired over the life course can be transmitted to the offspring, and may contribute to early cardiovascular phenotypes in the young generations. Hyperglycaemia and insulin resistance-key hallmarks of diabetes-induce an array of epigenetic modifications (i...
October 5, 2018: Journal of Endocrinological Investigation
A Basolo, S Heinitz, E J Stinson, B Begaye, M Hohenadel, P Piaggi, J Krakoff, S B Votruba
PURPOSE: Glucagon-like peptide 1 (GLP-1) is an incretin hormone that appears to play a major role in the control of food intake. The aim of this investigation was to evaluate and quantify the association of circulating GLP-1 concentration with ad libitum total calorie and macronutrient intake. METHODS: One-hundred and fifteen individuals (72 men) aged 35 ± 10 years were admitted for an inpatient study investigating the determinants of energy intake. Ad libitum food intake was assessed during 3 days using a reproducible vending machine paradigm...
October 3, 2018: Journal of Endocrinological Investigation
A K Arya, S K Bhadada, P Singh, D Dahiya, G Kaur, S Sharma, U N Saikia, A Behera, S D Rao, M Bhasin
OBJECTIVE: Molecular pathogenesis of parathyroid tumors is incompletely understood. Identification of novel molecules and understanding their role in parathyroid tumorigenesis by proteomics approach would be informative with potential clinical implications. METHOD: Adenomatous (n = 5) and normal (n = 2) parathyroid tissue lysates were analyzed for protein profile by LC-MS/MS method and the proteins were classified using bioinformatics tools such as PANTHER and toppfun functional enrichment tool...
October 3, 2018: Journal of Endocrinological Investigation
L Brčić, A Barić, S Gračan, M Brekalo, D Kaličanin, I Gunjača, V Torlak Lovrić, S Tokić, M Radman, V Škrabić, A Miljković, I Kolčić, M Štefanić, L Glavaš-Obrovac, D Lessel, O Polašek, T Zemunik, M Barbalić, A Punda, V Boraska Perica
PURPOSE: Hashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid diseases. Current knowledge of HT genetics is limited, and not a single genome-wide association study (GWAS) focusing exclusively on HT has been performed to date. In order to decipher genetic determinants of HT, we performed the first GWAS followed by replication in a total of 1443 individuals from Croatia. METHODS: We performed association analysis in a discovery cohort comprising 405 cases and 433 controls...
October 3, 2018: Journal of Endocrinological Investigation
M Zavattaro, C Ceruti, G Motta, S Allasia, L Marinelli, C Di Bisceglie, M P Tagliabue, M Sibona, L Rolle, F Lanfranco
PURPOSE: Varicocele is defined as a state of varicosity and tortuosity of the pampiniform plexus around the testis caused by retrograde blood flow through the internal spermatic vein. The prevalence of clinically relevant varicocele ranges from 5 to 20% in the male population and is often associated with infertility and reduction of sperm quality. In this review, the pathophysiology and clinical aspects of varicocele are reviewed along with therapeutic options and treatment effects on sperm parameters and fertility both in adult and in pediatric/adolescent subjects...
October 3, 2018: Journal of Endocrinological Investigation
W-Y Cai, J-S Gao, X Luo, H-L Ma, H Ge, N Liu, Q Xia, Y Wang, B-W Han, X-K Wu
PURPOSE: To investigate the effects of metabolic abnormalities, hyperandrogenemia and ovulation induction by clomiphene/acupuncture on liver function parameters among women with polycystic ovary syndrome (PCOS). METHODS: This is a secondary analysis of a randomized controlled trial. All 1000 subjects were diagnosed as PCOS by modified Rotterdam criteria. Liver function parameters, metabolic panel and hormone profile were measured at baseline and after treatment...
October 3, 2018: Journal of Endocrinological Investigation
D Lazzeri, P Pozzilli
No abstract text is available yet for this article.
October 3, 2018: Journal of Endocrinological Investigation
D Sun, Y-X Cao, X-D You, B-Y Zhou, S Li, Y-L Guo, Y Zhang, N-Q Wu, C-G Zhu, Y Gao, Q-T Dong, G Liu, Q Dong, J-J Li
PURPOSE: Though type 2 diabetes mellitus (T2DM) is an important and independent risk factor for coronary artery disease (CAD) in the general population, the impact of T2DM on CAD in patients with familial hypercholesterolemia (FH) is less understood. Thus, the current study aimed to examine the features of FH patients with T2DM and explore the effects of T2DM on CAD in FH. METHODS: A total of 289 clinical heterozygous FH (HeFH) patients diagnosed with Dutch Lipid Clinic Criteria were consecutively recruited and divided into a T2DM group (n = 58) and non-T2DM group (n = 231)...
October 1, 2018: Journal of Endocrinological Investigation
L Mu, R Li, Y Lai, Y Zhao, J Qiao
PURPOSE: The effects of adipose insulin resistance on cardiovascular risk factors in polycystic ovary syndrome (PCOS) remain largely unknown. We aimed to investigate associations between adipose insulin resistance and cardiovascular risk factors in PCOS. METHODS: A total of 207 PCOS and 47 non-PCOS women were recruited from a large reproductive medicine center in this cross-sectional study. The PCOS diagnosis was based on the Rotterdam Criteria. The subjects received a standard oral glucose tolerance test...
September 12, 2018: Journal of Endocrinological Investigation
S Seo, M Sánchez Robledo
PURPOSE: Over the past several decades, many papers have been published about the usefulness of thyrotropin receptor antibodies (TRAbs) as biomarkers of Graves' ophthalmopathy (GO). However, results have been inconsistent. The purpose of this analysis is to determine a possible cause of these discrepancies and to examine the usefulness of TRAbs as biomarkers for GO, especially 'thyrotropin-binding inhibiting immunoglobulin (TBII)' and 'thyroid-stimulating antibody (TSAb)'. METHOD: 26 articles discussing the association between TRAbs and GO were selected which were then divided into three groups based on the study method and whether or not the patients had been treated for hyperthyroidism...
September 7, 2018: Journal of Endocrinological Investigation
S Lopes-Ventura, M Pojo, A T Matias, M M Moura, I J Marques, V Leite, B M Cavaco
PURPOSE: Anaplastic thyroid carcinomas (ATCs) are non-responsive to multimodal therapy, representing one of the major challenges in thyroid cancer. Previously, our group has shown that genes involved in cell cycle are deregulated in ATCs, and the most common mutations in these tumours occurred in cell proliferation and cell cycle related genes, namely TP53, RAS, CDKN2A and CDKN2B, making these genes potential targets for ATCs treatment. Here, we investigated the inhibition of HRAS by tipifarnib (TIP) and cyclin D-cyclin-dependent kinase 4/6 (CDK4/6) by palbociclib (PD), in ATC cells...
September 6, 2018: Journal of Endocrinological Investigation
S Ozler, E Isci Bostanci, E Oztas, M Kuru Pekcan, B Gumus Guler, N Yilmaz
PURPOSE: We aimed to determine the relation of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS4), and a disintegrin and metalloproteinase with thrombospondin motifs-9 (ADAMTS9) with cardiovascular disease (CVD) risk, in ovarian dysfunction patients with premature ovarian insufficiency (POI), and idiopathic hypogonadotropic hypogonadism (IHH). METHODS: 43 IHH and 44 POI patients were enrolled to this case-control study. Serum hormonal parameters, lipid profiles, ADAMTS4 and ADAMTS9 levels were measured...
September 5, 2018: Journal of Endocrinological Investigation
I Ionni, G Rotondo Dottore, M Marinò
No abstract text is available yet for this article.
September 4, 2018: Journal of Endocrinological Investigation
M C Zatelli, L Lamartina, D Meringolo, E Arvat, L Damiani, G Grani, A Nervo, C Durante, L Giacomelli
PURPOSE: This study was aimed at assessing the incidence and timing of thyroid nodules recurrence, defined as appearance of new benign or malignant nodules in contralateral lobe in patients with benign thyroid nodules or thyroid microcarcinoma treated with lobo-isthmectomy. Patient's characteristics and risk factors associated with this phenomenon were also investigated. METHODS: A retrospective study was performed by evaluating 413 patients undergoing lobo-isthmectomy with a minimum follow-up of 1 year...
September 4, 2018: Journal of Endocrinological Investigation
F Karimi, G R Omrani
PURPOSE: Selenium (Se), an essential trace element, has been implicated in pathogenesis of autoimmune thyroiditis (AIT). Most studies attributed the immune modulating effects of Se to its antioxidant properties. However, there is insufficient evidence to support the use of selenium supplementation or other antioxidants in patients with AIT. This clinical trial was designed to investigate the impact of Se and vitamin C supplementation on antithyroid peroxidase antibody (TPO-Ab) level in patients with AIT...
September 4, 2018: Journal of Endocrinological Investigation
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