Rudolf Uher, Barbara Pavlova, Sara Najafi, Nitya Adepalli, Briana Ross, Emily Howes Vallis, Kathryn Freeman, Robin Parker, Lukas Propper, Lena Palaniyappan
Major depressive, bipolar, or psychotic disorders are preceded by earlier manifestations in behaviours and experiences. We present a synthesis of evidence on associations between person-level antecedents (behaviour, performance, psychopathology) in childhood, adolescence, or early adulthood and later onsets of major depressive disorder, bipolar disorder, or psychotic disorder based on prospective studies published up to September 16, 2022. We screened 11,342 records, identified 460 eligible publications, and extracted 570 risk ratios quantifying the relationships between 52 antecedents and onsets in 198 unique samples with prospective follow-up of 122,766 individuals from a mean age of 12...
March 15, 2024: Neuroscience and Biobehavioral Reviews