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Neuroscience and Biobehavioral Reviews

Xianwei Che, Cash Robin, Chung Sungwook, B Fitzgerald Paul, M Fitzgibbon Bernadette
Social support is demonstrated to have mixed effects on both pain and related physiological arousal. In this study, a meta-analysis was conducted to characterise these effects. A total of 2416 studies were identified in a systematic search, among which 21 were eligible for the quantitative review. The mere presence of another person was not sufficient to modulate pain perception. However, stranger presence was identified to decrease pain-related arousal (SMD = -0.31), and the presence of a significant other increased facial expression of pain (SMD = 0...
July 10, 2018: Neuroscience and Biobehavioral Reviews
Jorge Mendoza
Compulsive feeding has been considered as an addicted-like behavior with similarities to drug addiction. Food intake is brain controlled involving a balance between metabolic and hedonic pathways that modulate respectively how much and what is eaten. Pathological conditions such as compulsive feeding or an eating addiction can interfere with this balance and obesity may develop. Daily feeding times are also centrally controlled by the circadian clock in the suprachiasmatic nucleus. Disruptions of this body clock (e...
July 7, 2018: Neuroscience and Biobehavioral Reviews
Nadia Cattane, Juliet Richetto, Annamaria Cattaneoa
When considering neurodevelopmental disorders (NDDs), Schizophrenia (SZ) and Autism Spectrum Disorder (ASD) are considered to be among the most severe in term of prevalence, morbidity and impact on the society. Similar features and overlapping symptoms have been observed at multiple levels, suggesting common pathophysiological bases. Indeed, recent genome-wide association studies (GWAS) and epidemiological data report shared vulnerability genes and environmental triggers across the two disorders. In this review, we will discuss the possible biological mechanisms, including glutamatergic and GABAergic neurotransmissions, inflammatory signals and oxidative stress related systems, which are targeted by adverse environmental exposures and that have been associated with the development of SZ and ASD...
July 4, 2018: Neuroscience and Biobehavioral Reviews
Nandita Vijayakumar, Zdena Op de Macks, Elizabeth A Shirtcliff, Jennifer H Pfeifer
Alongside the exponential flourish of research on age-related trajectories of human brain development during childhood and adolescence in the past two decades, there has been an increase in the body of work examining the association between pubertal development and brain maturation. This review systematically examines empirical research on puberty-related structural and functional brain development in humans, with the aim of identifying convergent patterns of associations. We emphasize longitudinal studies, and discuss pervasive but oft-overlooked methodological issues that may be contributing to inconsistent findings and hindering progress (e...
July 1, 2018: Neuroscience and Biobehavioral Reviews
Morriss Jayne, Hoare Shannon, M van Reekum Carien
The recent meta-analysis by Fullana et al. (2018) is both timely and significant, providing a vital milestone towards understanding the neural networks involved in threat extinction in humans. Fullana et al. (2018) examined both threat extinction and recall separately using sophisticated meta-analytic methods based on raw contrast maps. Importantly, the meta-analysis highlighted a lack of consistent activation across studies for key neural "players" in the threat extinction circuit: the amygdala and ventromedial prefrontal cortex (vmPFC)...
June 30, 2018: Neuroscience and Biobehavioral Reviews
J Mayhew, B A Graham, Knut Biber, M Nilsson, F R Walker
Chronic stress has been extensively linked to disturbances in glutamatergic signalling. Emerging from this field of research is a considerable number of studies identifying the ability of purines at the pre-, post-, and peri-synaptic levels to tune glutamatergic neurotransmission. While the evidence describing purinergic control of glutamate has continued to grow, there has been relatively little attention given to how chronic stress modulates purinergic functions. The available research on this topic has demonstrated that chronic stress can not only disturb purinergic receptors involved in the regulation of glutamate neurotransmission, but also perturb glial-dependent purinergic signalling...
June 27, 2018: Neuroscience and Biobehavioral Reviews
Gabriele Bellucci, Chunliang Feng, Julia Camilleri, Simon B Eickhoff, Frank Krueger
Economic games -trust (TG) and ultimatum game (UG)- combined with fMRI have shown the importance of the anterior insula (AI) in social normative behaviors. However, whether different AI subregions are engaged in different cognitive and affective processes for social norm compliance and norm enforcement during social exchange remains elusive. Here, we investigated the role of the dorsal AI (dAI) and ventral AI (vAI), combining a coordinate-based meta-analysis of fMRI studies using the TG and UG with meta-analytic task-based and task-free connectivity analyses...
June 26, 2018: Neuroscience and Biobehavioral Reviews
Shannyn G Genders, Karlene J Scheller, Elvan Djouma
Addiction is a chronic, relapsing disorder characterised by the use of a substance or act to the point of compulsion. There are a number of medical treatments available for the intervention of these disorders, however, the effectiveness of current therapeutics is far from adequate. Neuropeptides are known to modulate addictive behaviours and may provide new therapeutic targets for the treatment of substance abuse. Accumulating evidence has suggested galanin as a potential important neuromodulator of addiction...
June 24, 2018: Neuroscience and Biobehavioral Reviews
Nic J A van der Wee, Amy C Bilderbeck, Maria Cabello, Jose L Ayuso-Mateos, Ilya M J Saris, Erik J Giltay, Brenda Wjh Penninx, Celso Arango, Anke Post, Stefano Porcelli
Social withdrawal is one of the first and common signs of early social dysfunction in a number of important neuropsychiatric disorders, likely because of the enormous amount and complexity of brain processes required to initiate and maintain social relationships (Adolphs, 2009). The Psychiatric Ratings using Intermediate Stratified Markers (PRISM) project focusses on the shared and unique neurobiological basis of social withdrawal in schizophrenia, Alzheimer and depression. In this paper, we discuss the working definition of social withdrawal for this study and the selection of objective and subjective rating scales to assess social withdrawal chosen or adapted for this project...
June 24, 2018: Neuroscience and Biobehavioral Reviews
Jessica E Bartley, Emily R Boeving, Michael C Riedel, Katherine L Bottenhorn, Taylor Salo, Simon B Eickhoff, Eric Brewe, Matthew T Sutherland, Angela R Laird
Problem solving is a complex skill engaging multi-stepped reasoning processes to find unknown solutions. The breadth of real-world contexts requiring problem solving is mirrored by a similarly broad, yet unfocused neuroimaging literature, and the domain-general or context-specific brain networks associated with problem solving are not well understood. To more fully characterize those brain networks, we performed activation likelihood estimation meta-analysis on 280 neuroimaging problem solving experiments reporting 3,166 foci from 1,919 individuals across 131 papers...
June 23, 2018: Neuroscience and Biobehavioral Reviews
Natàlia Vilor-Tejedor, Silvia Alemany, Alejandro Cáceres, Mariona Bustamante, Jesús Pujol, Jordi Sunyer, Juan R González
Imaging Genetics (IG) integrates neuroimaging and genomic data from the same individual, deepening our knowledge of the biological mechanisms behind neurodevelopmental domains and neurological disorders. Although the literature on IG has exponentially grown over the past years, the majority of studies have mainly analyzed associations between candidate brain regions and individual genetic variants. However, this strategy is not designed to deal with the complexity of neurobiological mechanisms underlying behavioral and neurodevelopmental domains...
June 23, 2018: Neuroscience and Biobehavioral Reviews
Florian Lange, Carolin Brückner, Aylin Knebel, Caroline Seer, Bruno Kopp
Executive dysfunctions are a frequently described non-motor symptom in patients with Parkinson's disease (PD). However, the nature, extent, variability, and determinants of executive dysfunctions in PD are still poorly understood. To improve the characterization of executive dysfunctions in PD, we conducted a meta-analysis of the studies administering the Wisconsin Card Sorting Test (WCST) to patients with PD and healthy controls. We included k = 161 studies, which allowed us to precisely estimate the size of PD-related WCST deficits and to run powerful tests for potential moderators of these deficits...
June 23, 2018: Neuroscience and Biobehavioral Reviews
M Anatürk, N Demnitz, K P Ebmeier, C E Sexton
Population aging has prompted considerable interest in identifying modifiable factors that may help protect the brain and its functions. Collectively, epidemiological studies show that leisure activities with high mental and social demands are linked with better cognition in old age. The extent to which socio-intellectual activities relate to the brain's structure is, however, not yet fully understood. This systematic review and meta-analysis summarizes magnetic resonance imaging studies that have investigated whether cognitive and social activities correlate with measures of gray and white matter volume, white matter microstructure and white matter lesions...
June 22, 2018: Neuroscience and Biobehavioral Reviews
Amy C Bilderbeck, Brenda W J H Penninx, Celso Arango, Nic van der Wee, René Kahn, Inge Winter-van Rossum, Anja Hayen, Martien J Kas, Anke Post, Gerard R Dawson
Trans-diagnostic, domain- or symptom-focused approaches have been heralded as advancing psychiatric research, but relatively few clinical research programmes have been undertaken to leverage their potential. In this manuscript we describe the approach and protocol for an exploratory study, PRISM (Psychiatric Ratings using Intermediate Stratified Markers), that will be conducted to explore the biomarkers in schizophrenia (SZ) and Alzheimer's Disease (AD) that may be related to a common symptom, social withdrawal...
June 22, 2018: Neuroscience and Biobehavioral Reviews
Danilo Arnone, Smita Saraykar, Haitham Salem, Antonio L Teixeira, Robert Dantzer, Sudhakar Selvaraj
Activation of the kynurenine pathway is one of the described mechanisms by which inflammation can induce depression. It involves multiple pathways including interference with the bioavailability of tryptophan central to the synthesis of the neurotransmitter serotonin. In this systematic review, we examine the relationship between kynurenine metabolites (kynurenine, kynurenic acid, tryptophan, quinolinic acid, the ratio of kynurenine and tryptophan) and mood disorders by conducting a meta-analysis. Fifty-six studies were identified, 21 met inclusion criteria and 14 were deemed suitable (9 investigating unipolar depression and 5 bipolar disorder)...
June 22, 2018: Neuroscience and Biobehavioral Reviews
T M Klein Gunnewiek, J R Homberg, T Kozicz
The biological background and consequences of serotonin transporter polymorphism-glucocorticoid relationship in individual differences in stress reactivity has been a major interest in neuropsychiatry research. Individual differences in glucocorticoid release have long been implicated in vulnerability to stress-related psychopathologies, like depression and anxiety in various species. Yet, it is largely elusive to what extent results from non-human primates and rodents translate to human findings. Based on our structured, comprehensive and non-hypothesis driven overview of this topic, we conclude that although gene-environment interaction studies have highlighted the importance of serotonin transporter polymorphism in modulating glucocorticoid release, there is compelling evidence that age, gender and ethnicity are significant factors too contributing to the equation...
June 22, 2018: Neuroscience and Biobehavioral Reviews
A Seizert Curtis
Despite having been recognized for many years, the mechanisms governing the male sexual refractory period (post-ejaculatory refractory period, post-ejaculatory interval) remain poorly understood. This review examines the brain and spinal areas putatively involved in this phenomenon to draw a coherent picture from the available data. It is hoped that this will reveal where further research will offer the potential for crucial insights on this topic.
June 22, 2018: Neuroscience and Biobehavioral Reviews
Salvatore Campanella, Elisa Schroder, Hendrik Kajosch, Xavier Noel, Charles Kornreich
Alcohol dependence is currently one of the most serious public health problems. Indeed, 3-8% of all deaths worldwide are attributable to effects of alcohol consumption. Although the first step in alcohol dependence treatment is straightforward, the main problem for clinicians lies with the prevention of relapse, as 40-70% of patients who only undergo psychosocial therapy resume alcohol use within a year following treatment. This review of the literature regarding event-related potentials (ERPs) is focused on two major neurocognitive factors that partially account for the inability of many alcoholics to remain abstinent: attentional biases towards alcohol-related stimuli that increase the urge to drink, and impaired response inhibition towards these cues that makes it more difficult for alcoholics to resist the temptation to drink...
June 21, 2018: Neuroscience and Biobehavioral Reviews
Victor Mathis, Paul J Kenny
Addiction is now recognized as a neurobiological and cognitive brain disorder and is generally viewed as a switch from recreational or voluntary to compulsive substance use despite aversive consequences. The habenula, composed of medial (MHb) and lateral (LHb) domains, has been implicated in regulating behavioral flexibility and anxiety-related behaviors and is considered a core component of the brain "anti-reward" system. These functions position the habenula to influence voluntary behaviors. Consistent with this view, emerging evidence points to alterations in habenula activity as important factors to contributing the loss of control over the use of drugs of abuse and the emergence of compulsive drug seeking behaviors...
June 21, 2018: Neuroscience and Biobehavioral Reviews
Mijna Hadders-Algra
This review summarizes early human brain development on the basis of neuroanatomical data and functional connectomics. It indicates that the most significant changes in the brain occur during the second half of gestation and the first three months post-term, in particular in the cortical subplate and cerebellum. As the transient subplate pairs a high rate of intricate developmental changes and interactions with clear functional activity, two phases of development are distinguished: a) the transient cortical subplate phase, ending at 3 months post-term when the permanent circuitries in the primary motor, somatosensory and visual cortices have replaced the subplate; and subsequently, b) the phase in which the permanent circuitries dominate...
June 20, 2018: Neuroscience and Biobehavioral Reviews
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