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Journal of Rheumatology. Supplement

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https://www.readbyqxmd.com/read/26523065/obituary-professor-antonio-spadaro
#1
Guido Valesini, Ignazio Olivieri
No abstract text is available yet for this article.
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523064/role-of-agents-other-than-tumor-necrosis-factor-blockers-in-the-treatment-of-psoriatic-arthritis
#2
REVIEW
Fabiola Atzeni, Luisa Costa, Francesco Caso, Raffaele Scarpa, Piercarlo Sarzi-Puttini
Psoriatic arthritis (PsA) is a systemic inflammatory disease characterized by possible peripheral and axial joint involvement, enthesitis, dactylitis, and skin and nail disease. It affects up to one-third of psoriatic patients, and may be associated with comorbidities such as cardiovascular and metabolic diseases. The usually prescribed initial treatment of moderate-severe PsA is methotrexate, which may be accompanied or replaced by a tumor necrosis factor (TNF) inhibitor such as etanercept, infliximab, or adalimumab...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523063/the-role-of-tumor-necrosis-factor-%C3%AE-blockers-in-psoriatic-disease-therapeutic-options-in-psoriatic-arthritis
#3
REVIEW
Olga Addimanda, Niccolò Possemato, Andrea Caruso, Nicolò Pipitone, Carlo Salvarani
Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting peripheral and axial joints, usually associated with psoriasis (PsO) and involving various systems and organs (eye inflammation, such as uveitis; and involvement of nail and enthesis), and it usually requires a multidisciplinary treatment approach. Tumor necrosis factor-α (TNF-α) is overexpressed in psoriatic synovium and skin plaques and its selective inhibition by anti-TNF-α agents has been demonstrated to reduce TNF-α levels in the articular environment, reversing the synovial hyperproliferative phenotype...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523062/new-approaches-in-tumor-necrosis-factor-antagonism-for-the-treatment-of-psoriatic-arthritis-certolizumab-pegol
#4
REVIEW
Alberto Cauli, Matteo Piga, Ennio Lubrano, Antonio Marchesoni, Alberto Floris, Alessandro Mathieu
The pathogenesis of psoriatic arthritis (PsA) is still under discussion but great advances have been made in the last 2 decades that confirm the central role of tumor necrosis factor-α (TNF-α) in its inflammatory milieu. New therapeutic approaches have been proposed, and new molecules with anti-TNF-α activity have been chemically altered to improve their pharmacological properties. Certolizumab pegol (CZP) is a PEGylated Fc-free anti-TNF that has been shown clinically to be effective in the treatment of rheumatoid arthritis (RA), skin psoriasis, and PsA...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523061/disease-modifying-antirheumatic-drugs-dmard-and-combination-therapy-of-conventional-dmard-in-patients-with-spondyloarthritis-and-psoriatic-arthritis-with-axial-involvement
#5
REVIEW
Davide Simone, Marcin Nowik, Elisa Gremese, Gianfranco F Ferraccioli
Treatment with nonsteroidal antiinflammatory drugs (NSAID) is the recommended first-line therapy in patients with axial spondyloarthritis (axSpA); and for those patients who have persistently active disease, the introduction of tumor necrosis factor-α (TNF-α) inhibitors is indicated. Conventional nonbiological disease-modifying antirheumatic drugs (DMARD), although effective and used in clinical practice for peripheral arthritis, are not recommended. Few studies have been conducted with the aim of evaluating the effect of conventional DMARD, either alone or in combination, in axSpA...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523060/psoriatic-disease-update-on-traditional-disease-modifying-antirheumatic-drugs
#6
REVIEW
Antonio Marchesoni, Ennio Lubrano, Alberto Cauli, Massimo Ricci, Maria Manara
We present an update on the effects of methotrexate (MTX), sulfasalazine (SSZ), leflunomide (LEF), and cyclosporine (CSA) in psoriatic arthritis (PsA) by reviewing data published from January 2010 to June 2014. The most relevant study on MTX, the Methotrexate In Psoriatic Arthritis (MIPA) trial, did not show a significant difference between this drug and placebo in improving peripheral synovitis. The trial, however, had several limitations. A cohort study on a small number of patients found that MTX does not inhibit radiographic progression...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523059/concept-of-remission-in-chronic-plaque-psoriasis
#7
REVIEW
Paolo Gisondi, Marco Di Mercurio, Luca Idolazzi, Giampiero Girolomoni
Psoriasis is a lifelong chronic inflammatory disease affecting 2-3% of the worldwide population. Current understanding of the pathogenesis of psoriasis assigns central importance to an interaction between acquired and innate immunity. The disease is characterized by a series of linked cellular changes in the skin, including hyperplasia of epidermal keratinocytes, angiogenesis, and infiltration of T lymphocytes, neutrophils, and other types of leukocytes in the affected skin. Plaque psoriasis is the most common clinical form and is characterized by red and scaly plaques generally localized at extensor sites such as elbows and knees...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523058/imaging-techniques-in-psoriatic-arthritis-update-2012-2014-on-current-status-and-future-prospects
#8
REVIEW
Elena Aleo, Stefania Migone, Valentina Prono, Francesca Barbieri, Giacomo Garlaschi, Marco A Cimmino
By providing additional and more sensitive information over clinical examination, imaging techniques are useful in the assessment of patients with psoriatic arthritis (PsA) and have been increasingly used to obtain additional clues to its pathogenesis. This review describes the current status and future development of conventional radiography, computed tomography, magnetic resonance imaging, positron emission tomography, and other novel techniques in the evaluation of PsA, with a focus on their use in diagnosing, monitoring, and predicting disease course and followup treatment response...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523057/ex-vivo-signaling-protein-mapping-in-t-lymphocytes-in-the-psoriatic-arthritis-joints
#9
Ugo Fiocco, Veronica Martini, Benedetta Accordi, Francesco Caso, Luisa Costa, Francesca Oliviero, Anna Scanu, Mara Felicetti, Paola Frallonardo, Monica Facco, Daniele Boso, Beatrice Molena, Renato Zambello, Roberta Ramonda, Franco Cozzi, Raffaele Scarpa, Giuseppe Basso, Gianpietro Semenzato, Jean-Michel Dayer, Andrea Doria, Leonardo Punzi
We assessed signaling protein mapping in total T cells, to analyze the proportions of T regulatory (Treg) and TCD4+ effector (Teff) cell phenotypes, and the respective interleukin 6Rα (IL-6Rα) expression in the inflammatory microenvironment of synovial fluid (SF) of patients with sustained psoriatic arthritis (PsA). Our approach was to measure the IL-6 level in SF using a multiplex bead immunoassay. Reverse-phase protein array was used to assess Janus kinase (JAK) 1 and JAK2, extra-cellular regulated kinase (ERK) 1 and 2, protein kinase Cδ (PKCδ), signal transducer and activator and transcription (STAT) 1, STAT3, and STAT5 phosphoproteins in total T cell lysates from SF of patients with PsA...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523056/an-integrative-approach-to-biomarker-development-in-psoriatic-arthritis
#10
REVIEW
Christopher T Ritchlin
The recent discovery that the interleukin 23/Th17 pathway is pivotal in the pathogenesis of psoriatic arthritis (PsA) creates new opportunities for the development of mechanistic biomarkers that will assist in the diagnosis and management of this disorder. While biomarkers are still in the discovery phase, new approaches including multiplex panels, fine sequencing of epigenetic and genetic data in non-coding regions of the human genome, and improved imaging modalities will likely foster the development of actionable biomarkers in PsA...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523055/the-definition-and-measurement-of-axial-psoriatic-arthritis
#11
REVIEW
Ennio Lubrano, Wendy Joanne Parsons, Antonio Marchesoni, Ignazio Olivieri, Salvatore D'Angelo, Alberto Cauli, Francesco Caso, Luisa Costa, Raffaele Scarpa, Luca Brunese
This review seeks to update the state of the art of axial psoriatic arthritis (axPsA). The definition and assessment of axPsA can be problematic because no agreement and no definitive data on this topic have been published, resulting in uncertainty as to the best approach to deal with these patients. A few recent scientific reports show new data on the possible coincidence of diffuse idiopathic skeletal hyperostosis and axPsA, as well as on the radiological assessment as measured with the validated instruments for axPsA...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523054/fragility-fractures-in-patients-with-psoriatic-arthritis
#12
Antonio Del Puente, Antonella Esposito, Luisa Costa, Carla Benigno, Aurora Del Puente, Francesca Foglia, Alfonso Oriente, Paolo Bottiglieri, Francesco Caso, Raffaele Scarpa
Psoriatic arthritis (PsA) can have peculiar effects on bone, including mechanisms of bone loss such as erosions, but also of bone formation, such as ankylosis or periostitis. The aim of the present study was to describe the prevalence of fractures in patients with PsA as compared to healthy controls and to investigate determinants of fractures among cases. For both cases and controls, radiographs were read to identify vertebral fractures (VF), and the presence of femoral neck or other nonvertebral fractures was obtained from patients' medical history...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523053/relationship-of-psoriatic-arthritis-to-other-spondyloarthritides
#13
Ignazio Olivieri, Salvatore D'Angelo, Michele Gilio, Carlo Palazzi, Ennio Lubrano, Angela Padula
In the early 1970s, Moll and co-workers formulated the unified concept of spondyloarthritides, a group of conditions sharing similar clinical features. Subsequently, criteria for their classification have been proposed by Amor and coworkers, the European Spondylarthropathy Study Group, and the Assessment in SpondyloArthritis international Society. Opinion, however, is divided between those who believe that the different entities of the complex represent the variable expression of the same disease ("lumpers") and those who think that these should be considered separately but under the same umbrella ("splitters")...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523052/psoriatic-arthritis-registries
#14
REVIEW
Piercarlo Sarzi-Puttini, Valentina Varisco, Maria Chiara Ditto, Maurizio Benucci, Fabiola Atzeni
The introduction of new biological drugs for the treatment of rheumatoid arthritis and spondyloarthritis has led to the creation of a number of registries in Europe and the United States. Most of them are sponsored by national rheumatology societies, and provide information that is useful in clinical practice concerning the clinical characteristics, efficacy, and safety of all licensed biological drugs. Their findings also help to improve our understanding of the quality of life and working ability of patients receiving biological drugs, and suggest methods for allocating resources...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523051/uveitis-in-spondyloarthritis-an-overview
#15
REVIEW
Fabrizio Cantini, Carlotta Nannini, Emanuele Cassarà, Olga Kaloudi, Laura Niccoli
Autoimmune anterior uveitis (AU) accounts for at least half of the cases of noninfectious uveitis, and similarly to spondyloarthritis (SpA), its occurrence is related to HLA-B27 positivity. AU is significantly more frequently found in HLA-B27-positive subjects with SpA and is characterized by unilateral eye involvement, marked tendency to recur with involvement of both eyes in alternate fashion, and has good prognosis in the majority of cases. The estimated frequency of SpA in patients with AU is around 50%, whereas AU in SpA has been reported in at least 30% of cases...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523050/psoriatic-disease-clinical-staging
#16
Raffaele Scarpa, Francesco Caso, Luisa Costa, Rosario Peluso, Angelo Spanò, Ennio Lubrano, Antonio Del Puente, John M H Moll
In 2006, the introduction of the concept "psoriatic disease" (PsD) extended the traditional idea of a condition confined to skin and joints. Now we consider PsD a systemic condition, in which the increased activity of tumor necrosis factor acts as the most potent engine for a series of molecular interactions. These lead not only to the genesis of skin and joint symptoms, but also to other clinical aspects such as inflammatory bowel disease, eye involvement, and metabolic syndrome. The blocking of a precise molecular target has dramatically modified therapeutic strategies, making possible adequate control of all the clinical aspects of the condition...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523049/inflammatory-bowel-diseases-and-spondyloarthropathies
#17
Paolo Gionchetti, Carlo Calabrese, Fernando Rizzello
Spondyloarthritis (SpA) is a group of diseases with similar clinical, radiologic, and serologic features, including SpA associated with inflammatory bowel disease (IBD-associated SpA). SpA is the most frequent extraintestinal manifestation in patients with IBD. Separate recommendations/guidelines are available for the treatment of axial and peripheral SpA and for both Crohn disease and ulcerative colitis. When IBD and SpA coexist, the therapeutic strategy should be modulated taking into account the variable manifestations and complications of IBD in terms of intestinal and extraintestinal features, and the clinical manifestations of SpA...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523048/translational-research-in-psoriasis
#18
Joerg Christoph Prinz
Translational research is a coordinated process that converts scientific knowledge about diseases from basic research into the development of therapeutic or diagnostic procedures in order to improve public health. Recent insights into the pathogenesis of psoriasis have greatly promoted the rational development of new therapeutic approaches. The integration of genetic predisposition and pathogenetic events defined the cytokine cascade as a target for therapeutic interventions. Applying various phases of translational research has enabled development of novel therapies that combine high efficacy with convincing safety profiles, with important implications for public health...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523047/toward-treating-to-target-in-psoriatic-arthritis
#19
Dafna D Gladman
The concept "treat to target" in rheumatology was first developed for rheumatoid arthritis. A similar attempt to develop such an approach for spondyloarthritis was unsuccessful because the assessment tools and target of therapy had not been developed. In psoriatic arthritis (PsA), composite indices to assess disease activity, disease state, and responsiveness have been developed and can be used as targets. There are a number of definitions for remission, but none are widely accepted. However, a state of minimal disease activity has been defined...
November 2015: Journal of Rheumatology. Supplement
https://www.readbyqxmd.com/read/26523046/verna-wright-lecture-psoriatic-arthritis-the-need-for-early-intervention
#20
Neil J McHugh
About 30% of individuals with skin psoriasis will develop an inflammatory disease of the peripheral or axial skeleton involving synovial and/or entheseal tissue termed psoriatic arthritis (PsA). In most cases psoriasis will precede PsA by several years. Hence skin psoriasis provides an opportune model to investigate genetic and environmental factors that interact and contribute to the development of a common form of inflammatory arthritis. Further, the preexisting presence of psoriasis represents a unique opportunity for the early detection of arthritis and the potential for more effective intervention...
November 2015: Journal of Rheumatology. Supplement
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