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Chinese Journal of Physiology

Salah Omar Bashir, Mohamed Darwesh Morsy, Abass Omar Elkarib, Humeda Suekit Humeda, Abdalla Abdelrahim Abusham, Moutasem Salih Aboonq, Ahmed Ibrahim Agamy
Involvement of leptin in the pathogensis of preeclampsia is still a controversy subject. Several researches reported the changes in serum leptin in high altitude residents. The aim of the present work was to investigate the impact of oxidative stress induced by high altitude (HA) residence on maternal serum leptin in preeclampsia and if there was a significant correlation between the serum leptin with either oxidative stress or endothelial inflammatory markers. One hundred fifty eight pregnant women were included in this study, divided into: low altitude normal pregnancies (NL), high altitude normal pregnancies (NH), low altitude preeclamptic (PL), and high altitude preeclamptic (PH) who presented to the obstetrics and gynecology outpatient clinic in both Muhayl (500 m over sea level) and Abha General Hospitals (all of them resident at Alsoda district with the average altitude 2700 m over sea level)...
January 29, 2018: Chinese Journal of Physiology
Ismaeel Bin-Jaliah, Hussein F. Sakr, Mohamed D. Morsy, Mohamed Dallak, Mohamed A. Haidara
The aim of this study is to investigate the effect of vanadium and or insulin on the proinflammatory biomarkers in type 2 diabetes mellitus rat model. Sixty male Sprague Dawley rats were divided into six groups (n = 10). Control group, control vanadium group, type 2 diabetes mellitus group, insulin-treated diabetic group, vanadium-treated diabetic group, and concomitant insulin and vanadium-treated diabetic group. At the end of the experiment, serum glucose, insulin, lipid profile, TNF-α, IL-6, high sensitivity C reactive protein (hs-CRP), ICAM-1, VCAM-1 and adiponectin were measured...
January 29, 2018: Chinese Journal of Physiology
Cheng-Neng Chen, Kuo-Chi Chang, Mao-Hsien Wang, Hsiang-Chien Tseng, Hung-Sheng Soung
Tardive dyskinesia (TD) is a severe side effect of chronic neuroleptic treatment consisting of abnormal involuntary movements, characterized by orofacial dyskinesia (OD). Haloperidol (HAL)- induced OD has been widely used as an animal model to study the neuropathophysiology of human tardive dyskinesia (TD) with its pathophysiology strongly associated with striatal oxidative stress. L-Theanine (LT), one of the major amino acid components in green tea, has potent antioxidative effects and is able to protect against various oxidative injuries...
January 29, 2018: Chinese Journal of Physiology
Jin-Sun Lee, Yuh-Yih Lin, Tsu-Shing Wang, Jer-Yuh Liu, Wei-Wen Lin, Jaw-Ji Yang
Sterile alpha motif- and leucine-zipper-containing kinase (ZAK) plays a role in the regulation of cell cycle progression and oncogenic transformation. The ZAK gene generates two transcript variants, ZAKα and ZAKβ, through alternative splicing. In this study, we identified that ZAKα proteins were upregulated in tumor tissues, whereas ZAKβ proteins were mostly expressed in corresponding normal tissues. The ectopically expressed ZAKβ proteins in cancer cells inhibited cancer cell proliferation as well as anchorage-independent growth...
January 29, 2018: Chinese Journal of Physiology
Chou-Ming Yeh, Yu-Jung Lin, Tien-Huan Hsu, Ting Ruan
Reactive oxygen species may induce hypersensitivity of vagal lung C-fibers (VLCFs) through the interaction of TRPA1 and P2X receptors. Genistein is a soy-derived isoflavone that exerts antioxidant effects by binding to estrogen receptors (ERs), ERα and ERβ. We investigated whether ER activation by genistein can suppress H₂O₂-mediated VLCF hypersensitivity and identified the types of ERs involved. Results revealed that subcutaneous injection of genistein or PPT (a selective ERα agonist) can attenuate H₂O₂-induced VLCF hypersensitivity...
January 29, 2018: Chinese Journal of Physiology
Tzu-Tung Chang, Chia-Jung Yang, Yu-Chi Lee, Sheng-Nan Wu
Telmisartan (Tel) is recognized as a non-peptide blocker of angiotensin II type-1 receptor. Whether this agent has any direct effects on ion currents remains unexplored. In whole-cell current recordings, addition of Tel increased the peak amplitude of voltage-gated Na⁺ current (INa) accompanied by the increased time constant of INa inactivation in differentiated NSC-34 motor neuron-like cells. Tel-stimulated INa in these cells is unlinked to either blockade of angiotensin II receptors or activation of PPAR-γ...
January 29, 2018: Chinese Journal of Physiology
Ching-Huang Lin, Jun-Yen Pan, Jung-Jui Chang, Hsin-Hung Chen, Pei-Wen Cheng, Ching-Jiunn Tseng
The growth factor midkine has been implicated in various biologic and pathologic events. It has been shown that the peripheral influence of midkine on cardiovascular regulation is due to an influence on the renin-angiotensin system. The nucleus tractus solitarii (NTS) is the primary integrative center for cardiovascular control and other autonomic functions in the central nervous system. However, the signaling mechanisms involved in midkine-mediated cardiovascular effects in the NTS remain unclear. In this study, we investigated whether the renin-angiotensin system and/ or N-methyl-D-aspartate (NMDA) receptor-calmodulin-eNOS signaling pathways were both involved in midkine-mediated blood pressure (BP) regulation in the NTS of Wistar-Kyoto rats...
December 15, 2017: Chinese Journal of Physiology
Kun-Yi Lin, Shao-Yu Peng, Chih-Jen Chou, Herng-Sheng Lee, Leou-Chyr Lin, Ru-Yu Pan, Shinn-Chih Wu
Recently, stem cells have offered an alternative treatment for inflammatory bowel disease or colitis to overcome the poor outcomes associated with current therapies. Amniotic fluid-derived stem cells have the potential for the regeneration of impaired organs and the recovery of normal physiologic functions of damaged tissues without ethical concerns or risk of tumor formation. In this work, we aimed to examine the therapeutic effects of infusion of porcine amniotic fluid-derived stem cells (pAFSCs) in dextran sulfate sodium (DSS)-induced colitis in mice...
December 15, 2017: Chinese Journal of Physiology
Qin Zheng, Yiling Jiang, Aiping Zhang, Lele Cui, Lemin Xia, Meihong Luo
Excessive platelet apoptosis is one of the pathogenic causes of immune-induced bone marrow failure (BMF). The aim of the present study was to explore the role of mitochondria-mediated pathway in the apoptosis of platelets in immune-induced BMF. An immune-induced BMF model was established in mice, which were randomly divided into three groups: normal control (CTL) group, BMF group and cyclosporine (CSA) group (n = 10 in each group). Mice were given 0.027 g/kg CSA daily in the cyclosporine group. Platelet count, mitochondrial transmembrane potential (ΔΨm), cytochrome C (CytC), phosphatidylserine (PS), calcium ion (Ca²⁺) and expression of proteins of the mitochondrial apoptotic pathway, including Bak, Bax, caspase-3, caspase-8 and caspase-9, was examined and compared...
December 15, 2017: Chinese Journal of Physiology
Rodrigo Rodrigues, Rodrigo de Azevedo Franke, Bruno Costa Teixeira, Rodrigo Cauduro de Oliveira Macedo, André Luiz Lopes, Álvaro Reischak-Oliveira, Bruno Manfredini Baroni, Marco Aurélio Vaz
Alcohol intake and sleep deprivation are conditions that cause changes in the physiological status. However, the relationship between biological markers and mood states is not entirely clear yet. The purpose of the study was to compare isolated and combined effects of alcohol intake and sleep deprivation on hormonal and inflammatory responses and in changes in the state of mood. Also, we intended to explain possible changes in mood states through biochemical variations using multiple stepwise regression analysis...
December 15, 2017: Chinese Journal of Physiology
Chun-Ju Yang, Ting-Shuo Huang, Tung-Liang Lee, Kang-Chung Yang, Shin-Sheng Yuan, Ruey-Hwa Lu, Chung-Ho Hsieh, Yu-Chiau Shyu
Few diagnostic biomarkers for sepsis after emergency peritonitis surgery are available to clinicians, and, thus, it is important to develop new biomarkers for patients undergoing this procedure. We investigated whether serum glutamine and selenium levels could be diagnostic biomarkers of sepsis in individuals recovering from emergency peritonitis surgery. From February 2012 to March 2013, patients who had peritonitis diagnosed at the emergency department and underwent emergency surgery were screened for eligibility...
December 15, 2017: Chinese Journal of Physiology
Kun-Ruey Shieh, Rong-Jie Chen, Shu-Chuan Yang
The diurnal rhythm is the common event in nature and specially shows in the behavioral patterns. Using the infrared sensor or photo beam detector to detect this 24-h rhythmicity in behaviors of mammalian, including in the rats and mice, is also the common way. The photo-sensory detecting mean is friendly and its advantage is unrestricted by light density and light-dark transition. However, this kind of equipment is cost-expensive and uneasy to fit for home cage in rodents. In this study, we tried to use the video-tracking system to detect the rhythmic activity of rats in their home cages...
December 15, 2017: Chinese Journal of Physiology
Jeong Beom Lee, Hyung Seok Seo, Young Oh Shin
The sweating response is modulated in two different ways depending on adaptation conditions. In this work, we examined sudomotor activities before and after intensive and repetitive heat exposure. Nine male volunteers were exposed to 30-min half-body immersion in hot water (42 ± 0.5°C) at the same time of day on alternate days for 3 weeks. All experiments were performed in an automated climate chamber. Tympanic (Tty) and skin (Ts) temperatures were measured. Mean body temperature (mTb) was calculated. Sudomotor activities, including sweat onset time, sweat rate and volume, activated sweat gland density (ASGD) and output (ASGO), were tested in four regions of the skin: chest, abdomen, upper back and thigh...
October 31, 2017: Chinese Journal of Physiology
Pantelis T. Nikolaidis, Beat Knechtle
Little is known for pacing profiles in age groups cross-country skiers. The aim of the present study was to examine the effect of sex, age and calendar year on pacing strategies in the largest ski marathon in the world. All finishers (n = 66,435) in ‘Vasaloppet’ from 2012 to 2016 were examined for 12 different age groups (G). There was an association between age group and sex (χ² = 1091.1, P < 0.001; Cramer’s V = 0.13, P < 0.001), where the men-to-women ratio in each age group ranged from 3.29 (in G₂₀) to 64...
October 31, 2017: Chinese Journal of Physiology
Su-Xi Wu, Xiao-Miao Han, Xue-Wei Jiang, Jun Tao
Investigating anti-aging factors that is more effective than antioxidants has important theoretical significance and application value. In search for nutritional ingredients that are more effective in anti-aging, two different multivitamins (multivitamin-1 at a dose of 2.5 mg/kg body weight [BW]/day; multivitamin-2 at a dose of 5.4 mg/kg BW/day) were administered to aging mice (N = 40) induced by D-galactose. The content or activity of the biochemical components associated with aging and anti-aging in the brain and the liver of the experimental mice was then determined for analysis of statistically significant difference among the groups...
October 31, 2017: Chinese Journal of Physiology
Chi-Ting Horng, Chiang-Ting Chou, Te-Kung Sun, Wei-Zhe Liang, Chun-Chi Kuo, Jue-Long Wang, Pochuen Shieh, Chung-Ren Jan
Carvacrol, a monoterpenic phenol compound, has been shown to possess various biological effects in different models. However, the effect of carvacrol on intracellular Ca²⁺ and its related physiology in human prostate cancer is unknown. This study explored the effect of carvacrol on cytosolic free Ca²⁺ levels ([Ca²⁺]i) and viability in PC3 human prostate cancer cells. Fura-2, a Ca²⁺- sensitive fluorescent dye, was used to assess [Ca²⁺]i. Cell viability was measured by the detecting reagent WST-1...
October 31, 2017: Chinese Journal of Physiology
Jin-Sun Lee, Tsu-Shing Wang, Ming Cheng Lin, Wei-Wen Lin, Jaw-Ji Yang
Curcumin, a popular yellow pigment of the dietary spice turmeric, has been reported to inhibit cell growth and to induce apoptosis in a wide variety of cancer cells. Although numerous studies have investigated anticancer effects of curcumin, the precise molecular mechanism of action remains unidentified. Whereas curcumin mediates cell survival and apoptosis through mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling cascades, its impact on the upstream regulation of MAPK is unclear...
October 31, 2017: Chinese Journal of Physiology
Li-Chuan Huang, Hock-Kean Liew, Hung-Yu Cheng, Hsiao-Fen Peng, Hui-I Yang, Jon-Son Kuo, Wen-Lin Hsu, Cheng-Yoong Pang
Basal ganglia hemorrhage accounts for approximately 50% of all hemorrhagic strokes. A good rat model that produces severe intrastriatal hemorrhage (ISH) mimicking human severe ISH is lacking. The present study compared the intra-striatal injection of 0.2 U with that of 0.6 U of collagenase in inducing severe ISH in rats. Three-Tesla (3T) magnetic resonance imaging (MRI) was used to evaluate brain injuries in terms of hematoma size (volume), midline shift (MLS), and brain edema. This evaluation was further substantiated by determination of behavior and neurologic functions and mortality over 56 h...
October 31, 2017: Chinese Journal of Physiology
Ching-Wen Chang, Yi-Han Chen, Yu-Chin Lin, Wen-Huang Peng
Taiwan wild grape (Vitis thunbergii var. taiwaniana; VTT) is an important traditional herbal medicine used to treat muscle injuries and acute and chronic pain of the ligaments. Information on its bioactivity and the underlying mechanisms, which have not been elucidated thus far, is needed to demonstrate its value for pharmacological and clinical use. This study presents evidence to clarify the antinociceptive and anti-inflammatory activities of an ethanolic extract of VTT stem (VTTEtOH) and the possible molecular mechanisms involved in such biactivities...
August 31, 2017: Chinese Journal of Physiology
Daniela Chlíbková, Thomas Rosemann, Beat Knechtle, Pantelis T. Nikolaidis, Alena Žákovská, Karl Sudi
A The incidence of exercise-associated hyponatremia (EAH) is higher in women than in men. We present three cases of a very mild post-race EAH in female winners of three 24-h ultra races in various weather conditions and disciplines with post-race plasma sodium [Na⁺] levels of 134 mM (Case 1), 133 mM (Case 2) and 134 mM (Case 3). Moreover, Case 1 and Case 2 showed elevated creatine kinase concentrations of >10,000 U/l with an absence of renal function abnormality. The common characteristics were female sex, veteran recreational category, long race experience in the particular sports discipline, excellent race performance, similar total weekly training hours and the presence of luteal phase of the menstrual cycle during the race...
August 31, 2017: Chinese Journal of Physiology
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