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Chinese Journal of Physiology

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https://www.readbyqxmd.com/read/29742817/effects-of-thyroid-dysfunction-on-reproductive-hormones-in-female-rats
#1
Juan Liu, Meng Guo, Xusong Hu, Xuechun Weng, Ye Tian, Kaili Xu, Dai Heng, Wenbo Liu, Yu Ding, Yanzhou Yang, Cheng Zhang
Thyroid hormones (THs) play a critical role in the development of ovarian cells. Although the effects of THs on female reproduction are of great interest, the mechanism remains unclear. We investigated the effects of TH dysregulation on reproductive hormones in rats. Propylthiouracil (PTU) and L-thyroxine were administered to rats to induce hypo- and hyper-thyroidism, respectively, and the reproductive hormone profiles were analyzed by radioimmunoassay. Ovarian histology was evaluated with H&E staining, and gene protein level or mRNA content was analyzed by western blotting or RT-PCR...
May 10, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29742816/angiostrongylus-cantonensis-conditioned-culture-medium-induces-myelin-basic-protein-alterations-via-erk1-2-and-nf-%C3%AE%C2%BAb-activation-in-rat-rsc-96-schwann-cells
#2
Jo-Ping Chin, Chien-Min Chen, Tsong-Hai Lee, Chii-Wen Chou, Cheng-You Lu
Eating of excessive raw or undercooked environmental snails produces Angiostrongyliasis demyelination caused by Angiostrongylus cantonensis. The aim of this study was to investigate the association between extracellular signal-regulated kinase (Erk)1/2-nuclear factor (NF)-κB pathway and myelin basic protein (MBP) expression in RSC 96 Schwann cells treated with A. cantonensis- conditioned culture medium, which was prepared by culturing the third-stage (L3) nematode larvae in DMEM for 72 h. The supernatants were collected and filtered before use...
May 10, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29689688/swimming-exercise-induced-reversed-expression-of-mir-96-and-its-target-gene-nav1-3-in-diabetic-peripheral-neuropathy-in-rats
#3
Amir Mahmoudi Aghdam, Parviz Shahabi, Elham Karimi-Sales, Rafigheh Ghiasi, Saeed Sadigh-Eteghad, Javad Mahmoudi, Mohammad Reza Alipour
Diabetes is a common metabolic disease which leads to diabetic peripheral neuropathy. Recently, the role of microRNA-96 (miR-96) in alleviating neuropathic pain by inhibiting the expression of NaV1.3, an isoform of voltage-gated sodium channels, has been shown. Peripheral nerve injuries result in NaV1.3 elevation. Exercise has beneficial role in diabetes management and peripheral neuropathy. However, the effects of exercise on miR-96 and its target gene NaV1.3 in diabetic rats are unknown. Therefore, the present study investigated the effects of exercise training on the expression of miR-96 and NaV1...
April 25, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29660975/synergistic-effects-of-psychosocial-stress-and-mild-peripheral-infection-on-inducing-microglial-activation-in-the-hippocampal-dentate-gyrus-and-long-lasting-deficits-in-hippocampus-related-memory
#4
Wen-Yu Tzeng, Chien-Chou Su, Li-Han Sun, Chianfang G. Cherng, Lung Yu
Lipopolysaccharide (LPS) treatment and stress may cause immune activation in the brain, an event which has been thought to play a role in mediating stress-induced cognitive dysfunction. However, the enduring impact of psychosocial stress on brain immune activation or cognitive deficits has not been well investigated. Likewise, it remains unexplored whether there exist synergistic effects of psychosocial stress and a weak systemic LPS treatment on brain immune activation and/or cognitive function. In this work, a 10-day social defeat regimen was used to model psychosocial stress and the number and density of ionized calcium-binding adaptor molecule 1 (Iba1)-stained microglia was used to reveal brain immune activation in male Balb/C mice...
April 17, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29590745/high-frequency-stimulation-of-the-subthalamic-nucleus-activates-motor-cortex-pyramidal-tract-neurons-by-a-process-involving-local-glutamate-gaba-and-dopamine-receptors-in-hemi-parkinsonian-rats
#5
Chi-Fen Chuang, Chen-Wei Wu, Ying Weng, Pei-San Hu, Shin-Rung Yeh, Yen-Chung Chang
Deep brain stimulation (DBS) is widely used to treat advanced Parkinson’s disease. Here, we investigated how DBS applied on the subthalamic nucleus (STN) influenced the neural activity in the motor cortex. Rats, which had the midbrain dopaminergic neurons partially depleted unilaterally, called the hemi-Parkinsonian rats, were used as a study model. c-Fos expression in the neurons was used as an indicator of neural activity. Application of high-frequency stimulation (HFS) upon the STN was used to mimic the DBS treatment...
March 29, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29526078/hot-water-bathing-impairs-training-adaptation-in-elite-teen-archers
#6
Ta-Cheng Hung, Yi-Hung Liao, Yung-Shen Tsai, Lisa Ferguson-Stegall, Chia-Hua Kuo, Chung-Yu Chen
Despite heat imposes considerable physiological stress to human body, hot water immersion remains as a popular relaxation modality for athletes. Here we examined the lingering effect of hot tub relaxation after training on performance-associated measures and dehydroepiandrosterone sulfate (DHEA-S) in junior archers. Ten national level archers, aged 16.6 ± 0.3 years (M = 8, F = 2), participated in a randomized counter-balanced crossover study after baseline measurements. In particular, half participants were assigned to the hot water immersion (HOT) group, whereas another halves were assigned to the untreated control (CON) group...
April 30, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29526077/sex-differences-in-the-age-of-peak-marathon-race-time
#7
Pantelis T. Nikolaidis, Thomas Rosemann, Beat Knechtle
Recent studies showed that women were older than men when achieving their fastest marathon race time. These studies, however, investigated a limited sample of athletes. We investigated the age of peak marathon performance in a large sample of female and male marathon finishers by using data from all finishers. We analyzed the age of peak marathon performance in 1-year and 5-year age intervals of 451,637 runners (i.e. 168,702 women and 282,935 men) who finished the ‘New York City Marathon’ between 2006 and 2016, using analysis of variance and non-linear regression analysis...
April 30, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29526076/semen-parameter-alteration-histological-changes-and-role-of-oxidative-stress-in-adult-rat-epididymis-on-exposure-to-electronic-cigarette-refill-liquid
#8
Dalila Rahali, Aicha Jrad-Lamine, Yosra Dallagi, Yassine Bdiri, Nathalie Ba, Michele El May, Saloua El Fazaa, Narges El Golli
Electronic cigarettes (e-cigarettes) are devices intended to substitute conventional cigarettes, with the aim of being less harmful. In a previous report, we showed that intraperitoneal (i.p.) injection of e-cigarette liquid (E-liquid), with or without nicotine, induced toxicity in the testes of Wistar rats by disrupting oxidative balance and steroidogenesis. In the present work, we further evaluated the impact of e-liquid with or without nicotine on the epididymis of rats using the same procedure. Results showed that e-liquid treatments led to alteration of semen parameters, with a significant drop of at least 50% in sperm vitality, a significant increase of morphologically abnormal spermatozoa and an imbalance of redox status in comparison to the control group...
April 30, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29526075/inverse-correlation-between-methylation-and-expression-of-the-delta-like-ligand-1-gene-in-gastric-cancer
#9
Chien-Heng Shen, Shui-Yi Tung, Min-Jen Tseng, Yu-Wei Leu
Notch signaling is a candidate pathway that transmits environmental information into the cell and interferes with the epigenome of gastric cancer. This study aimed to explore if the Notch pathway was abnormally regulated during gastric tumorigenesis. To achieve the goal, Delta-like ligand 1 (DLL1) gene expression, Notch upstream signal, promoter methylation and its correlation with DLL1 expression were examined by methylation-specific polymerase chain reaction (PCR) and real-time PCR (RT-PCR) in cultured gastric cancer cell lines or gastric cancer patient samples...
April 30, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29374959/impact-of-high-altitude-on-maternal-serum-leptin-level-and-its-correlation-with-oxidative-stress-and-endothelial-inflammatory-markers-in-preeclamptic-women
#10
Salah Omar Bashir, Mohamed Darwesh Morsy, Abass Omar Elkarib, Humeda Suekit Humeda, Abdalla Abdelrahim Abusham, Moutasem Salih Aboonq, Ahmed Ibrahim Agamy
Involvement of leptin in the pathogensis of preeclampsia (PE) is still a controversy subject. Several researches reported the changes in serum leptin in high altitude (HA) residents. The aim of the present work was to investigate the impact of oxidative stress (OS) induced by HA residence on maternal serum leptin in PE and if there was a significant correlation between the serum leptin with either OS or endothelial inflammatory markers. One hundred fifty eight pregnant women were included in this study, divided into: low altitude normal pregnancies (NL), HA normal pregnancies (NH), low altitude preeclamptic (PL), and HA preeclamptic (PH) who presented to the obstetrics and gynecology outpatient clinic in both Muhayl (500 m over sea level) and Abha General Hospitals (all of them resident at Alsoda district with the average altitude 2700 m over sea level)...
February 28, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29374958/modulatory-effect-of-concomitant-administration-of-insulin-and-vanadium-on-inflammatory-biomarkers-in-type-2-diabetic-rats-role-of-adiponectin
#11
Ismaeel Bin-Jaliah, Hussein F. Sakr, Mohamed D. Morsy, Mohamed Dallak, Mohamed A. Haidara
The aim of this study is to investigate the effect of vanadium and/or insulin on the proinflammatory biomarkers in type 2 diabetes mellitus (T2DM) rat model. Sixty male Sprague Dawley rats were divided into six groups (n = 10). Control group, control vanadium group, T2DM group, insulin-treated diabetic group, vanadium-treated diabetic group, and concomitant insulin and vanadium-treated diabetic group. At the end of the experiment, serum glucose, insulin, lipid profile, tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), high sensitivity C reactive protein (hs- CRP), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and adiponectin were measured...
February 28, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29374957/protective-effect-of-l-theanine-on-haloperidol-induced-orofacial
#12
Cheng-Neng Chen, Kuo-Chi Chang, Mao-Hsien Wang, Hsiang-Chien Tseng, Hung-Sheng Soung
Tardive dyskinesia (TD) is a severe side effect of chronic neuroleptic treatment consisting of abnormal involuntary movements, characterized by orofacial dyskinesia (OD). Haloperidol (HAL)- induced OD has been widely used as an animal model to study the neuropathophysiology of human TD with its pathophysiology strongly associated with striatal oxidative stress. L-Theanine (LT), one of the major amino acid components in green tea, has potent antioxidative effects and is able to protect against various oxidative injuries...
February 28, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29374956/antitumorigenic-effects-of-zak%C3%AE-an-alternative-splicing-isoform-of-zak
#13
Jin-Sun Lee, Yuh-Yih Lin, Tsu-Shing Wang, Jer-Yuh Liu, Wei-Wen Lin, Jaw-Ji Yang
Sterile alpha motif (SAM)- and leucine-zipper-containing kinase (ZAK) plays a role in the regulation of cell cycle progression and oncogenic transformation. The ZAK gene generates two transcript variants, ZAKα and ZAKβ, through alternative splicing. In this study, we identified that ZAKα proteins were upregulated in tumor tissues, whereas ZAKβ proteins were mostly expressed in corresponding normal tissues. The ectopically expressed ZAKβ proteins in cancer cells inhibited cancer cell proliferation as well as anchorage-independent growth...
February 28, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29374955/genistein-suppressing-the-ros-induced-hypersensitivity-of-rat-vagal-lung-c-fiber-afferents-through-an-er%C3%AE-mediated-mechanism
#14
Chou-Ming Yeh, Yu-Jung Lin, Tien-Huan Hsu, Ting Ruan
Reactive oxygen species (ROS) may induce hypersensitivity of vagal lung C-fibers (VLCFs) through the interaction of transient receptor potential ankyirn 1 (TRPA1) and P2X receptors. Genistein is a soy-derived isoflavone that exerts antioxidant effects by binding to estrogen receptors (ERs), ERα and ERβ. We investigated whether ER activation by genistein can suppress H₂O₂-mediated VLCF hypersensitivity and identified the types of ERs involved. Results revealed that subcutaneous injection of genistein or 4,4',4"-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT, a selective ERα agonist) can attenuate H₂O₂-induced VLCF hypersensitivity...
February 28, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29374954/stimulatory-action-of-telmisartan-an-antagonist-of-angiotensin-ii-receptor-on-voltage-gated-na%C3%A2-%C2%BA-current-experimental-and-theoretical-studies
#15
Tzu-Tung Chang, Chia-Jung Yang, Yu-Chi Lee, Sheng-Nan Wu
Telmisartan (Tel) is recognized as a non-peptide blocker of AT1R. Whether this agent has any direct effects on ion currents remains unexplored. In whole-cell current recordings, addition of Tel increased the peak amplitude of voltage-gated Na⁺ (NaV) current (INa) accompanied by the increased time constant of INa inactivation in differentiated NSC-34 motor neuron-like cells. Tel-stimulated INa in these cells is unlinked to either blockade of AT1R or activation of peroxisome proliferator-activated receptor gamma (PPAR-γ)...
February 28, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29241309/involvement-of-endothelial-nitric-oxide-synthase-activation-in-midkine-mediated-central-hypotensive-effects
#16
Ching-Huang Lin, Jun-Yen Pan, Jung-Jui Chang, Hsin-Hung Chen, Pei-Wen Cheng, Ching-Jiunn Tseng
The growth factor midkine (MK) has been implicated in various biologic and pathologic events. It has been shown that the peripheral influence of MK on cardiovascular regulation is due to an influence on the renin-angiotensin system (RAS). The nucleus tractus solitarii (NTS) is the primary integrative center for cardiovascular control and other autonomic functions in the central nervous system. However, the signaling mechanisms involved in MK-mediated cardiovascular effects in the NTS remain unclear. In this study, we investigated whether the RAS and/or N-methyl-D-aspartate (NMDA) receptor-calmodulin-endothelial nitric oxide synthase (eNOS) signaling pathways were both involved in MK-mediated blood pressure (BP) regulation in the NTS of Wistar-Kyoto (WKY) rats...
December 31, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29241308/infusion-of-porcine-derived-amniotic-fluid-stem-cells-for-treatment-of-experimental-colitis-in-mice
#17
Kun-Yi Lin, Shao-Yu Peng, Chih-Jen Chou, Herng-Sheng Lee, Leou-Chyr Lin, Ru-Yu Pan, Shinn-Chih Wu
Recently, stem cells have offered an alternative treatment for inflammatory bowel disease (IBD) or colitis to overcome the poor outcomes associated with current therapies. Amniotic fluid-derived stem cells (AFSCs) have the potential for the regeneration of impaired organs and the recovery of normal physiologic functions of damaged tissues without ethical concerns or risk of tumor formation. In this work, we aimed to examine the therapeutic effects of infusion of porcine AFSCs (pAFSCs) in dextran sulfate sodium (DSS)-induced colitis in mice...
December 31, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29241307/the-mechanism-of-mitochondria-mediated-pathway-in-the-apoptosis-of-platelets-in-immune-induced-bone-marrow-failure
#18
Qin Zheng, Yiling Jiang, Aiping Zhang, Lele Cui, Lemin Xia, Meihong Luo
Excessive platelet apoptosis is one of the pathogenic causes of immune-induced bone marrow failure (BMF). The aim of the present study was to explore the role of mitochondria-mediated pathway in the apoptosis of platelets in immune-induced BMF. An immune-induced BMF model was established in mice, which were randomly divided into three groups: normal control (CTL) group, BMF group and cyclosporine (CSA) group (n = 10 in each group). Mice were given 0.027 g/kg CSA daily in the CSA group. Platelet count (PLT), mitochondrial transmembrane potential (ΔΨm), cytochrome C (CytC), phosphatidylserine (PS), calcium ion (Ca²⁺) and expression of proteins of the mitochondrial apoptotic pathway, including Bak, Bax, caspase-3, caspase-8 and caspase-9, was examined and compared...
December 31, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29241306/combined-and-isolated-effects-of-alcohol-intake-and-one-night-of-sleep-deprivation-on-mood-states-hormonal-and-inflammatory-responses-in-healthy-male-adults-a-crossover-randomized-controlled-trial
#19
Rodrigo Rodrigues, Rodrigo de Azevedo Franke, Bruno Costa Teixeira, Rodrigo Cauduro de Oliveira Macedo, André Luiz Lopes, Álvaro Reischak-Oliveira, Bruno Manfredini Baroni, Marco Aurélio Vaz
Alcohol (ALC) intake and sleep deprivation (SDP) are conditions that cause changes in the physiological status. However, the relationship between biological markers and mood states is not entirely clear yet. The purpose of the study was to compare isolated and combined effects of ALC intake and SDP on hormonal and inflammatory responses and in changes in the state of mood. Also, we intended to explain possible changes in mood states through biochemical variations using multiple stepwise regression analysis...
December 31, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29241305/serum-glutamine-levels-as-a-potential-diagnostic-biomarker-in-sepsis-following-surgery-for-peritonitis
#20
Chun-Ju Yang, Ting-Shuo Huang, Tung-Liang Lee, Kang-Chung Yang, Shin-Sheng Yuan, Ruey-Hwa Lu, Chung-Ho Hsieh, Yu-Chiau Shyu
Few diagnostic biomarkers for sepsis after emergency peritonitis surgery are available to clinicians, and, thus, it is important to develop new biomarkers for patients undergoing this procedure. We investigated whether serum glutamine and selenium levels could be diagnostic biomarkers of sepsis in individuals recovering from emergency peritonitis surgery. From February 2012 to March 2013, patients who had peritonitis diagnosed at the emergency department and underwent emergency surgery were screened for eligibility...
December 31, 2017: Chinese Journal of Physiology
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