Read by QxMD icon Read

JPEN. Journal of Parenteral and Enteral Nutrition

Merin Kinikini
Studies discussing inflammation and oxidative stress state that these conditions are known contributors in the pathogenesis of cholestatic diseases and ulcerative colitis, and studies examining patients with liver disease have found decreased antioxidant status and significant elevation of lipid peroxides as compared with healthy subjects. One hypothesis in liver disease is that deficient antioxidant defense mechanisms may lead to excess oxygen free radical formation, which promotes deleterious processes in the liver...
November 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Ryan T Hurt, Manpreet S Mundi
Home parenteral nutrition (HPN) is a life-saving therapy for patients who are not able to use their gastrointestinal tract. There are a number of complications associated with HPN, including metabolic bone disease, intestinal failure-associated liver disease (IFALD), and catheter-related bloodstream infections. We present a case of a 32-year-old HPN patient who initially developed biopsy-proven IFALD (total bilirubin, 2.4 mg/dL) while on long-term HPN. His HPN was initiated due to myopathic intestinal dysmotility and pseudo-obstruction when he was 15 years old...
November 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Chengsi Ong, Jan Hau Lee, Melvin K S Leow, Zudin A Puthucheary
Evidence suggests that critically ill children develop muscle wasting, which could affect outcomes. Muscle ultrasound has been used to track muscle wasting and association with outcomes in critically ill adults but not children. This review aims to summarize methodological considerations of muscle ultrasound, structural findings, and possibilities for its application in the assessment of nutrition and functional outcomes in critically ill children. Medline, Embase, and CINAHL databases were searched up until April 2016...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Ronald L Koretz
No abstract text is available yet for this article.
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Enid E Martinez, Luis M Pereira, Kathleen Gura, Nicole Stenquist, Katelyn Ariagno, Samuel Nurko, Nilesh M Mehta
BACKGROUND: Delayed gastric emptying (GE) impedes enteral nutrient (EN) delivery in critically ill children. We examined the correlation between (a) bedside EN intolerance assessments, including gastric residual volume (GRV); (b) delayed GE; and (c) delayed EN advancement. MATERIALS AND METHODS: We prospectively enrolled patients ≥1 year of age, eligible for gastric EN and without contraindications to acetaminophen. Gastric emptying was determined by the acetaminophen absorption test, specifically the area under the curve at 60 minutes (AUC60)...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Robert MacLaren
No abstract text is available yet for this article.
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Adam Rahman, Ravi Agarwala, Claudio Martin, Dave Nagpal, Michael Teitelbaum, Daren K Heyland
BACKGROUND: Malnutrition is a predictor of poor outcome following cardiac surgery. We define nutrition therapy after cardiac surgery to identify opportunities for improvement. METHODS: International prospective studies in 2007-2009, 2011, and 2013 were combined. Sites provided institutional and patient characteristics from intensive care unit (ICU) admission to ICU discharge for a maximum of 12 days. Patients had valvular, coronary artery bypass graft (CABG) surgery, or combined procedures and were mechanically ventilated and staying in the ICU for ≥3 days...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Hannah G Piper, Di Fan, Laura A Coughlin, Evi X Ho, Margaret M McDaniel, Nandini Channabasappa, Jiwoong Kim, Minsoo Kim, Xiaowei Zhan, Yang Xie, Andrew Y Koh
BACKGROUND: Children with short bowel syndrome (SBS) can vary significantly in their growth trajectory. Recent data have shown that children with SBS possess a unique gut microbiota signature compared with healthy controls. We hypothesized that children with SBS and poor growth would exhibit more severe gut microbiota dysbiosis compared with those with SBS who are growing adequately, despite similar intestinal anatomy. MATERIALS AND METHODS: Stool samples were collected from children with SBS (n = 8) and healthy controls (n = 3) over 3 months...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Inez Martincevic, Marialena Mouzaki
BACKGROUND: The mainstay of treatment for pediatric nonalcoholic fatty liver disease (NAFLD) is lifestyle modification, which includes dietary changes that lead to slow but sustained weight loss or weight stabilization in growing children. Accurate estimation of energy requirements is necessary to achieve this goal. The objective of this study was to assess the accuracy of the most commonly used equations in predicting the resting energy expenditure (REE) of children with NAFLD. METHODS: This was a retrospective study performed in a single institution...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Kateřina Jiroutková, Adéla Krajčová, Jakub Žiak, Michal Fric, Jan Gojda, Valér Džupa, Martin Kalous, Jana Tůmová, Jan Trnka, František Duška
BACKGROUND: Functional mitochondria in skeletal muscle of patients with protracted critical illness and intensive care unit-acquired weakness are depleted, but remaining mitochondria have increased functional capacities of respiratory complexes II and III. This can be an adaptation to relative abundancy of fatty acid over glucose caused by insulin resistance. We hypothesized that the capacity of muscle mitochondria to oxidize fatty acid is increased in protracted critical illness. METHODS: We assessed fatty acid oxidation (FAO) and mitochondrial functional indices in vitro by using extracellular flux analysis in cultured myotubes obtained by isolating and culturing satellite cells from vastus lateralis muscle biopsy samples from patients with ICU-acquired weakness (n = 6) and age-matched healthy controls (n = 7)...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
David C Frankenfield, Christine M Ashcraft
BACKGROUND: There are many equations used for calculating energy needs of nutrition support patients but few developed specifically for the subset of spontaneously breathing acutely ill patients. The purpose of the current study was to validate existing equations and to start developing new equations for this cohort. METHODS: Acutely ill patients not requiring mechanical ventilation had their resting metabolic rate measured using an indirect calorimeter. Metabolic rate was also calculated using the Mifflin-St Jeor equation, the Ireton-Jones equation for spontaneously breathing patients, and a modification of the Penn State equation in which the minute ventilation-dependent variable was removed...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Anders Skallerup, Louis Nygaard, Søren Schou Olesen, Lars Vinter-Jensen, Marianne Køhler, Henrik Højgaard Rasmussen
BACKGROUND AND AIMS: Intestinal failure (IF) is a serious and common complication of short bowel syndrome with patients depending on parenteral nutrition (PN) support. Effective nutrition management requires an accurate estimation of the patient's basal metabolic rate (BMR) to avoid underfeeding or overfeeding. However, indirect calorimetry, considered the gold standard for BMR assessment, is a time- and resource-consuming procedure. Consequently, several equations for prediction of BMR have been developed in different settings, but their accuracy in patients with IF are yet to be investigated...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Jorge Emilio Alfonso, David Berlana, Andrew Ukleja, Joseph Boullata
BACKGROUND: Multichamber bags (MCBs) may offer potential clinical, ergonomic, and economic advantages compared with (hospital) pharmacy compounded bags (COBs) and multibottle systems (MBSs). METHODS: A systematic literature review was performed to identify and assess the available evidence regarding advantages of MCBs compared with COBs and MBSs. Medline, Embase, the Cochrane Databases, and EconLit were searched for articles reporting clinical, ergonomic, and economic outcomes for MCBs compared with COBs or MBSs...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Christopher Filtenborg Brandt, Mark Hvistendahl, Rahim M Naimi, Siri Tribler, Michael Staun, Per Brøbech, Palle Bekker Jeppesen
BACKGROUND/AIMS: In Denmark, the public healthcare system ensures patients with intestinal failure (IF) the same rights for a life-saving treatment as patients with other organ failures. This study reports the epidemiological data from the largest Danish IF center. As one of the pioneering centers in treating IF with home parenteral nutrition (HPN), this study documents the HPN evolution and describes the demographics and outcome in one of the world's largest single-center cohorts. METHODS: We included patients with IF discharged with HPN from 1970-2010...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Stephanie Dobak, Fred Rincon
BACKGROUND: Therapeutic moderate hypothermia (MH; T core 33°C-34°C) is being studied for treatment of spontaneous intracerebral hemorrhage (ICH). Nutrition assessment begins with accurate basal metabolic rate (BMR) determination. Although early enteral nutrition (EN) is associated with improved outcomes, it is often deferred until rewarming. We sought to determine the accuracy of predictive BMR equations and the safety and tolerance of EN during MH after ICH. MATERIALS AND METHODS: Patients were randomized to 72 hours of MH or normothermia (NT; T core 36°C-37°C)...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Adam Kuchnia, Carrie Earthman, Levi Teigen, Abigail Cole, Marina Mourtzakis, Michael Paris, Willem Looijaard, Peter Weijs, Heleen Oudemans-van Straaten, Gregory Beilman, Andrew Day, Roger Leung, Charlene Compher, Rupinder Dhaliwal, Sarah Peterson, Hannah Roosevelt, Daren K Heyland
BACKGROUND: In critically ill patients, muscle loss is associated with adverse outcomes. Raw bioelectrical impedance analysis (BIA) parameters (eg, phase angle [PA] and impedance ratio [IR]) have received attention as potential markers of muscularity, nutrition status, and clinical outcomes. Our objective was to test whether PA and IR could be used to assess low muscularity and predict clinical outcomes. METHODS: Patients (≥18 years) having an abdominal computed tomography (CT) scan and admitted to intensive care underwent multifrequency BIA within 72 hours of scan...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Wei Wu, Ming Zhong, Du-Ming Zhu, Jie-Qiong Song, Jun-Feng Huang, Qun Wang, Li-Jie Tan
BACKGROUND: Early use of enteral nutrition (EN) is indicated following surgical resection of esophageal cancer. However, early EN support does not always meet the optimal calorie or protein requirements, and the benefits of supplementary parenteral nutrition (PN) remain unclear. We aimed to evaluate the efficacy and safety of early supplementary PN following esophagectomy. MATERIALS AND METHODS: We enrolled 80 consecutive patients who underwent esophagectomy. Resting energy expenditure and body composition measurements were performed in all patients preoperatively and postoperatively...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Manpreet S Mundi, Nishanth Vallumsetla, Jacob B Davidson, Megan T McMahon, Sara L Bonnes, Ryan T Hurt
BACKGROUND: Bariatric surgery is one of the most effective techniques for achieving sustained weight loss but can be associated with surgical complications or malabsorption so significant that it leads to malnutrition. Parenteral nutrition (PN) may be necessary to help treat surgical complications or malnutrition from these procedures. There are limited data describing this patient population and role for home PN (HPN). METHODS: A retrospective review of our HPN database was conducted to identify patients who were initiated on HPN between January 1, 2003, and August 31, 2015, and had a history of bariatric surgery...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Hakeam A Hakeam, Hamdy A Mulia, Ayman Azzam, Tarek Amin
BACKGROUND: Hyperglycemia is a major complication of parenteral nutrition (PN). Guidelines for hyperglycemia management in noncritically ill patients cite basal insulin administration but do not recommend a regimen. The GLUCOSE-in-PN study aimed to compare the efficacy of glargine insulin versus continuously infused regular insulin in PN (RI-in-PN) to achieve glycemic control in noncritically ill surgical patients with diabetes who were receiving PN. METHODS: This prospective randomized open-label study was conducted at King Faisal Specialist Hospital and Research Centre...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Rani A Bashir, Allison M Callejas, Horacio C Osiovich, Joseph Y Ting
BACKGROUND: Although peripherally inserted central catheters (PICCs) provide vascular access in newborns who require parenteral nutrition and medications, they can be associated with complications that lead to significant morbidity and mortality. OBJECTIVES: To describe the characteristics of pleural effusion (PLE) associated with PICC use in a large level III neonatal intensive care unit. DESIGN/METHODS: A retrospective review of PICC-related PLE in newborns was conducted over a 5-year period, from 2008-2012...
September 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"