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Clinical and Investigative Medicine. Médecine Clinique et Experimentale

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https://www.readbyqxmd.com/read/29603690/the-2nd-annual-clinical-scientist-trainee-symposium-august-22-2017-london-canada
#1
Charles Yin, Jessica N Blom, James F Lewis
Clinician scientists play a critical role in bridging research and clinical practice. Unfortunately, the neglect of research training in medical schools has created clinicians who are unable to translate evidence from literature to practice. Furthermore, the erosion of research training in medical education has resulted in clinicians who lack the skills required for successful scientific investigation. To counteract this, the Schulich School of Medicine & Dentistry has made an effort to engage trainees, at all levels, in the research process...
March 27, 2018: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29603689/cim-journal-club-gene-therapy-for-spinal-muscular-atrophy-comment-on-mendell-et-al-n-engl-j-med-2017-377-1713-22
#2
Raphael Schneider
In their landmark paper, Mendell et al. show that infants with spinal muscular atrophy (SMA) reached important motor milestones and survived longer when treated with AVXS-101 (AveXis), a viral vector containing DNA encoding the survival of motor neuron protein (SMN). Patients not only crawled, stood and walked independently, but learned to speak. These results are very encouraging for patients with SMA and offer hope for pediatric and adult patients with other types of motor neuron diseases.
March 27, 2018: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29603688/serum-level-of-fetuin-b-is-associated-with-osteoporosis-a-4-year-prospective-study-in-china
#3
Zhong-Hua Xu, Jin He, Xing Zhang, Hua Xie, Zhong-Hua Zhou, Ya-Wen Sun, Xiang Luo
PURPOSE: As a novel hepatokine, fetuin B involves in various functions of energy metabolism. Recent advance reveals a complex interaction between bone and liver via the secretion of hepatokines. The association between serum fetuin B and osteoporosis was evaluated in a 4-year hospital-based prospective study of 1,370 Chinese postmenopausal women. METHODS: Bone mineral densities (BMDs) were obtained on femoral neck and lumbar spines by dual energy X-ray absorptiometry...
March 27, 2018: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29603687/mir-7-mir-9-and-mir-375-contribute-to-effect-of-exendin-4-on-pancreatic-%C3%AE-cells-in-high-fat-diet-fed-mice
#4
Chang Guo, Yi-Qiong Sun, Qiang Li, Jin-Chao Zhang
PURPOSE: The purpose of this study was to test whether glucagon-like peptide-1 (GLP-1) receptor activation preserved pancreatic β-cells via the regulation of microRNAs and target genes in high-fat-diet-fed mice. METHODS: C57BL/6 male mice were simultaneously treated with high-fat-diet (HFD) and GLP-1 analogue, Exendin-4 (Ex-4) (3 μg/kg/day or 30 μg/kg/day), i.p. or vehicle, for consecutive 13 weeks. Fasting blood glucose, postprandial blood glucose, ΔI30/ΔG30, HOMA-IR and HOMA-% β were measured in each group...
March 27, 2018: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29603686/dose-adjustment-of-immunosuppressants-during-co-administration-of-posaconazole-a-systematic-review
#5
Chengcheng Fu, Jia Chen, Yang Xu, Depei Wu
PURPOSE: The purpose of this retrospective study was to analyze the dose adjustment of immunosuppressants (cyclosporine, tacrolimus and sirolimus) for the patients with allogeneic hematopoietic stem cell and solid-organ (heart/lung) transplantation during co-administration of posaconazole. METHODS: MEDLINE, EMBASE and Cochrane Library were searched from January 1, 2000 to June 30, 2017 for clinical reports of patients who received allogeneic hematopoietic stem cell and organ transplantation and were co-administered posaconazole and immunosuppressants (cyclosporine, tacrolimus or sirolimus)...
March 27, 2018: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29603685/newsletter-spring-2018-clinician-investigator-trainee-association-of-canada-citac
#6
Tianwei E Zhou, Kirill Zaslavsky, Kristen Barton, Karen J Abraham, Robert Bortolussi
A decade of CITAC Annual General Meetings: 2007-2017 In 2007, the Clinician Investigator Trainee Association of Canada (CITAC) launched its inaugural Annual General Meeting (AGM). The AGM has since become a major annual event, jointly organized by CITAC and leaders from the Canadian Society for Clinical Investigation (CSCI), and continues to provide a forum for clinician investigator (CI) trainees to exchange ideas, advance career prospects and engage with the broader community. Indeed, since its inception, all Canadian institutions with medical doctor and clinician investigator (MD+CI) training programs have participated in the AGM, while more than 1,000 trainees have registered as CITAC members...
March 27, 2018: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29256391/pattern-reversal-visual-evoked-potentials-in-adults-variability-with-age
#7
Raja Sawaya, Helen Sawaya, Gilbert Youssef
PURPOSE: Pattern reversal visual evoked potential (PRVEP) is an electrophysiological test for evaluating the visual pathway. This study measured the changes in the latencies and amplitudes of the PRVEP with age and gender in normal subjects. METHODS: Healthy participants (n=81; 162 total eyes), between the ages of 20 and 92 years were recruited for the study. Stimulation was performed monocularly with a high-contrast (>50%) black-white checkerboard pattern with a check size of 30° at a reversal rate of 2 Hz, a band-pass of 1-100 Hz, a sweep of 250 msec and an average of 150 stimulations in a dark room...
December 17, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29256390/predicting-acute-kidney-injury-following-transcatheter-aortic-valve-replacement
#8
Jeffrey A Marbach, Joshua Feder, Altayyeb Yousef, F Daniel Ramirez, Trevor Simard, Pietro DiSanto, Juan J Russo, Paul Boland, Marino Labinaz, Christopher Glover, Alexander Dick, Benjamin Hibbert
PURPOSE: Acute kidney injury occurs in up to a quarter of patients following transcatheter aortic valve replacement (TAVR) and has been associated with increased short and long-term mortality rates. A variety of patient characteristics predictive of post-TAVR acute kidney injury (AKI) have been identified, however discrepancies among studies exist almost uniformly. We investigated the hypothesis that the change in glomerular filtration rate (ΔGFR) in response to contrast administered during pre-TAVR coronary angiography is predictive of ΔGFR post-TAVR...
December 17, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29256389/adolescent-obesity-and-the-role-of-the-fat-mass-and-obesity-associated-gene-polymorphism
#9
Nilgün Çöl, Beltinge Demircioğlu-Kiliç, Muradiye Nacak, Mustafa Araz
PURPOSE: The association between fat mass and obesity-associated (FTO) gene and obesity is unclear in both adults and adolescents. The aim of this study was to examine the role of the FTO gene variant rs9939609 as a candidate gene for obesity and the relationship between insulin resistance (IR), metabolic syndrome (MetS), estimated glomerular filtration rate (eGFR) and neutrophil-to-lymphocyte ratio (NLR). METHODS: Obese adolescents (n=100) and healthy controls (n=100) were included...
December 17, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29256388/plaque-distribution-in-common-femoral-artery-bifurcations-based-on-multi-slice-computed-tomography-assessment
#10
Bihui Zhang, Min Yang, Yinghua Zou
PURPOSE: The aim of this study was to observe the exact plaque distribution at the common femoral artery bifurcation by multi-slice computed tomography angiography and to examine the relationship between plaque distribution and carina location. METHODS: Symptomatic outpatients who underwent multi-slice computed tomography angiography between May 2013 and February 2015 were enrolled in this study. The presence and distribution of atherosclerotic plaques were assessed in cross section views of vessel lumen...
December 17, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29256387/association-among-tenascin-c-and-nt-probnp-levels-and-arrhythmia-prevalence-in-heart-failure
#11
Caglar Ozmen, Ali Deniz, Onur S Deveci, Caglar E Cagliyan, Aziz I Celik, İbrahim Yildiz, Pinar Ö Yildiz, Mesut Demir, Mehmet Kanadasi
PURPOSE: Tenascin-C (TN-C) and amino-terminal fragment of the B-type natriuretic peptide (NT-proBNP) are the important predictors in prognosis of heart failure (HF). The aim of this study was to analyze the relationship of TN-C and NT-proBNP levels with the frequency and severity of ventricular arrhythmia. MATERIALS AND METHODS: Our study included 107 HF patients with EF < 45%. According to Holter analysis, the patients were divided into two groups as malignant arrhythmia group (n=29) with Lown Class 4a and 4b arrhythmia and benign arrhythmia group(n=78) with Lown Class 0-3b arrhythmia...
December 17, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29256386/editor-s-comment-and-announcement
#12
Robert Bortolussi
It is hard to believe but Clinical and Investigative Medicine (CIM), the official journal of Canadian Society for Clinical Investigation (CSCI), will soon celebrate its 40th birthday!  Over these past four decades, CIM has been the premier journal for Canadian clinician scientists; publishing over 1,000 articles on breakthroughs and major advances from Canada and around the world.  We are listed on Medline, PubMed and the Library of Science. We have been, and will continue to be, an independent journal...
December 17, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29061226/scientific-overview-on-csci-citac-annual-general-meeting-and-2016-young-investigators-forum
#13
Tianwei E Zhou, Kristen I Barton, Elina Cook, Matthew G K Benesch, Nicholas Jette, Christophe Moderie, Katarina Ondrusova, Caitlin Lees, Patrick E Steadman, Tina B Marvasti, Sara Mirali, Peter J Liu, Ege M Babadagli, Kara J Abraham, Kirill J Zaslavsky
The 2016 Annual General Meeting of the Canadian Society of Clinician Investigators (CSCI) and Clinician Investigator Trainee Association of Canada/Association des Cliniciens-Chercheurs en Formation du Canada (CITAC/ACCFC) was a national conference held in Toronto November 21-23, 2016, in conjunction with The University of Toronto Clinician Investigator Program Research Day. The theme for this year's meeting was "Mapping Your Career as a Clinician-Scientist"; emphasizing essential skills for developing a fruitful career as clinician-scientist...
October 19, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29061225/combination-of-%C3%AE-blocker-and-5%C3%AE-reductase-inhibitor-for-treatment-of-benign-prostatic-hyperplasia
#14
Deying Kang, Caoyang Hu, Yanyan Fu, Dongwen Wang
PURPOSE: This study compared the efficacy of an α-blocker monotherapy alone with a combination of α-blocker plus 5α-reductase in treatment of benign prostatic hyperplasia (BPH). METHODS: Medline (PubMed), EMBASE, CENTRAL (Cochrane databases) and Google Scholar were searched until May 2015 using the following search terms: ([α-blocker] AND 5α-reductase inhibitor) AND benign prostatic hyperplasia; and benign prostatic hyperplasia AND (adrenergic alpha blockers OR 5 alpha reductase inhibitor)...
October 19, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29061224/glucagon-like-peptide-1-levels-and-dipeptidyl-peptidase-4-activity-in-type-2-diabetes
#15
Abdulhalim Senyigit, Omur Tabak, Timur Orhanoglu, Aytac Karadag, Serdal Ugurlu, Hafize Uzun, Dildar Konukoglu
PURPOSE: Hyperglycemia is the major risk factor for microvascular complications in type 2 diabetes mellitus (T2DM) patients. This randomized controlled clinical trial aimed to investigate T2DM patients with microvascular complications with regard to possible relations among serum clusterin (CLU), amylin, secreted frizzled-related protein-4 (SFRP-4), glucagon-like peptide-1 (GLP-1) and dipeptidyl peptidase-4 (DPP-4) activities. METHODS: Subject groups were defined as follows: T2DM without complications (n=25, F/M=9/16, age 53...
October 19, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29061223/association-between-donor-and-recipient-interleukin-18-gene-polymorphisms-and-the-risk-of-infection-after-liver-transplantation
#16
Bao-Jie Shi, Xiao-Yu Yu, Hao Li, Tong-Hai Xing, Jun-Wei Fan, Pei-Wen Wang, Zhi-Hai Peng, Lin Zhong
PURPOSE: The purpose of this study was to retrospectively evaluate the association between Interleukin-18 (IL-18) gene polymorphisms of the donor and recipient in liver transplant patients with bacterial infections. METHODS: Five single nucleotide polymorphisms (SNPs) (rs7106524, rs5744247, rs1946518, rs549908 and rs187238) of the IL-18 gene from the donors were genotyped and their association with post-operative bacterial infections was evaluated in liver transplant patients (N=113)...
October 19, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28875928/the-association-of-hla-dqb1-0602-but-not-hla-drb1-15-with-obstructive-sleep-apnea
#17
Suleiman M Momany, Thamer A Al-Qatarneh, Yousef S Khader, Nizar M Abu-Harfeil, Ammar K Daoud, Amjad A Mahasneh
PURPOSE: Obstructive sleep apnea (OSA) is a sleep breathing disorder with unclear multifactorial pathogenesis. This study aimed to investigate the association between OSA and two human leukocyte antigens (HLA) alleles; DQB1*0602 and DRB1*15. METHODS: Forty patients with OSA and 40 control subjects were enrolled in the study. OSA diagnosis was made utilizing the Apnea-Hypopnea Index (AHI)≥5 in overnight polysomnography (PSG). AHI was also used to determine OSA severity...
August 29, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28875927/ascending-aortic-diameter-is-associated-with-hypertension-in-korean-men
#18
Eunkyung Suh, Jae-Hong Ryoo, Miae Doo, Hong Soo Lee, Sang Wha Lee, Kyung Won Shim, Ju Young Lee, A Ri Byun, Hyejin Chun
PURPOSE: The purpose of this study was to evaluate the association between ascending aortic diameter (AAD) as measured with low-dose chest computed tomography (LDCT) and hypertension in Korean men. METHODS: Korean men (n=1,050) who were screened for lung cancer using LDCT imaging at a health promotion center in Seoul, Korea between January 1 and December 31were recruited for the study. AAD is the longest length of ascending aorta measured from approximately 15 mm above left main coronary ostium to the mid-slice level of the right pulmonary artery...
August 29, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28653616/head-to-head-comparisons-of-bisphosphonates-and-teriparatide-in-osteoporosis-a-meta-analysis
#19
Chun-Lin Liu, Han-Chung Lee, Chun-Chung Chen, Der-Yang Cho
PURPOSE: This meta-analysis aimed to compare the efficacy and safety of teriparatide vs. bisphosphonates in the management of osteoporosis. METHODS: A total of 1,967 patients from eight randomized controlled trials were analyzed; outcomes included bone mineral density (BMD) of the femoral neck, total hip and lumbar spine, vertebral and nonvertebral fractures and any adverse event. A subgroup analysis of treatment effectiveness was performed according to the etiology of osteoporosis; i...
June 26, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28653615/maternal-and-neonatal-morbidity-repeat%C3%A2-cesarean-versus-a%C3%A2-trial-of-labour-after-previous%C3%A2-cesarean%C3%A2-delivery
#20
Yue-Zhou Yang, Xu-Ping Ye, Xiao-Xi Sun
PURPOSE: The purpose of this study was to perform a meta-analysis comparing the rates of uterine rupture, and other maternal and neonatal complications, between women who undergo a trial of labour (TOL) after a prior Cesarean delivery and those to undergo elective repeat Cesarean delivery (ERCD). SOURCE: Medline, Cochrane, EMBASE and Google Scholar were searched until May 6, 2015 using the keywords/phrases: trial of labour, Cesarean section, elective, repeat, pregnancy and vaginal birth...
June 26, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
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