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Annual Review of Neuroscience

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https://www.readbyqxmd.com/read/27442071/face-processing-systems-from-neurons-to-real-world-social-perception
#1
Winrich Freiwald, Bradley Duchaine, Galit Yovel
Primate face processing depends on a distributed network of interlinked face-selective areas composed of face-selective neurons. In both humans and macaques, the network is divided into a ventral stream and a dorsal stream, and the functional similarities of the areas in humans and macaques indicate they are homologous. Neural correlates for face detection, holistic processing, face space, and other key properties of human face processing have been identified at the single neuron level, and studies providing causal evidence have established firmly that face-selective brain areas are central to face processing...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27442070/from-cajal-to-connectome-and-beyond
#2
Larry W Swanson, Jeff W Lichtman
One goal of systems neuroscience is a structure-function model of nervous system organization that would allow mechanistic linking of mind, brain, and behavior. A necessary but not sufficient foundation is a connectome, a complete matrix of structural connections between the nodes of a nervous system. Connections between two nodes can be described at four nested levels of analysis: macroconnections between gray matter regions, mesoconnections between neuron types, microconnections between individual neurons, and nanoconnections at synapses...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27442069/3-d-maps-and-compasses-in-the-brain
#3
Arseny Finkelstein, Liora Las, Nachum Ulanovsky
The world has a complex, three-dimensional (3-D) spatial structure, but until recently the neural representation of space was studied primarily in planar horizontal environments. Here we review the emerging literature on allocentric spatial representations in 3-D and discuss the relations between 3-D spatial perception and the underlying neural codes. We suggest that the statistics of movements through space determine the topology and the dimensionality of the neural representation, across species and different behavioral modes...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27145916/correlations-and-neuronal-population-information
#4
Adam Kohn, Ruben Coen-Cagli, Ingmar Kanitscheider, Alexandre Pouget
Brain function involves the activity of neuronal populations. Much recent effort has been devoted to measuring the activity of neuronal populations in different parts of the brain under various experimental conditions. Population activity patterns contain rich structure, yet many studies have focused on measuring pairwise relationships between members of a larger population-termed noise correlations. Here we review recent progress in understanding how these correlations affect population information, how information should be quantified, and what mechanisms may give rise to correlations...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27145915/reward-and-aversion
#5
Hailan Hu
To benefit from opportunities and cope with challenges in the environment, animals must adapt their behavior to acquire rewards and to avoid punishments. Maladaptive changes in the neuromodulatory systems and neural circuits for reward and aversion can lead to manifestation of several prominent psychiatric disorders including addiction and depression. Recent progress is pushing the boundaries of knowledge on two major fronts in research on reward and aversion: First, new layers of complexity have been reported on the functions of dopamine (DA) and serotonin (5-HT) neuromodulatory systems in reward and aversion...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27145914/maps-of-the-auditory-cortex
#6
Alyssa A Brewer, Brian Barton
One of the fundamental properties of the mammalian brain is that sensory regions of cortex are formed of multiple, functionally specialized cortical field maps (CFMs). Each CFM comprises two orthogonal topographical representations, reflecting two essential aspects of sensory space. In auditory cortex, auditory field maps (AFMs) are defined by the combination of tonotopic gradients, representing the spectral aspects of sound (i.e., tones), with orthogonal periodotopic gradients, representing the temporal aspects of sound (i...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27145913/the-genetic-basis-of-hydrocephalus
#7
Maria Kousi, Nicholas Katsanis
Studies of syndromic hydrocephalus have led to the identification of >100 causative genes. Even though this work has illuminated numerous pathways associated with hydrocephalus, it has also highlighted the fact that the genetics underlying this phenotype are more complex than anticipated originally. Mendelian forms of hydrocephalus account for a small fraction of the genetic burden, with clear evidence of background-dependent effects of alleles on penetrance and expressivity of driver mutations in key developmental and homeostatic pathways...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27145912/new-perspectives-on-genomic-imprinting-an-essential-and-multifaceted-mode-of-epigenetic-control-in-the-developing-and-adult-brain
#8
Julio D Perez, Nimrod D Rubinstein, Catherine Dulac
Mammalian evolution entailed multiple innovations in gene regulation, including the emergence of genomic imprinting, an epigenetic regulation leading to the preferential expression of a gene from its maternal or paternal allele. Genomic imprinting is highly prevalent in the brain, yet, until recently, its central roles in neural processes have not been fully appreciated. Here, we provide a comprehensive survey of adult and developmental brain functions influenced by imprinted genes, from neural development and wiring to synaptic function and plasticity, energy balance, social behaviors, emotions, and cognition...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27145911/the-emergence-of-a-circuit-model-for-addiction
#9
Christian Lüscher
Addiction is a disease of altered behavior. Addicts use drugs compulsively and will continue to do so despite negative consequences. Even after prolonged periods of abstinence, addicts are at risk of relapse, particularly when cues evoke memories that are associated with drug use. Rodent models mimic many of the core components of addiction, from the initial drug reinforcement to cue-associated relapse and continued drug intake despite negative consequences. Rodent models have also enabled unprecedented mechanistic insight into addiction, revealing plasticity of glutamatergic synaptic transmission evoked by the strong activation of mesolimbic dopamine-a defining feature of all addictive drugs-as a neural substrate for these drug-adaptive behaviors...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27090954/dorsal-anterior-cingulate-cortex-a-bottom-up-view
#10
Sarah R Heilbronner, Benjamin Y Hayden
The dorsal anterior cingulate cortex (dACC) has attracted great interest from neuroscientists because it is associated with so many important cognitive functions. Despite, or perhaps because of, its rich functional repertoire, we lack a single comprehensive view of its function. Most research has approached this puzzle from the top down, using aggregate measures such as neuroimaging. We provide a view from the bottom up, with a focus on single-unit responses and anatomy. We summarize the strengths and weaknesses of the three major approaches to characterizing the dACC: as a monitor, as a controller, and as an economic structure...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27090953/brain-disorders-due-to-lysosomal-dysfunction
#11
Alessandro Fraldi, Andrés D Klein, Diego L Medina, Carmine Settembre
Recent studies of autophagic and lysosomal pathways have significantly changed our understanding of lysosomes; once thought to be simple degradative and recycling centers, lysosomes are now known to be organelles capable of influencing signal transduction, via the mammalian target of rapamycin complex 1 (mTORC1), and regulating gene expression, via transcription factor EB (TFEB) and other transcription factors. These pathways are particularly relevant to maintaining brain homeostasis, as dysfunction of the endolysosomal and autophagic pathways has been associated with common neurodegenerative diseases, such as Alzheimer's, Parkinson's, and Huntington's, and lysosomal storage disorders, a group of inherited disorders characterized by the intralysosomal buildup of partially degraded metabolites...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27090952/computational-analysis-of-behavior
#12
S E Roian Egnor, Kristin Branson
In this review, we discuss the emerging field of computational behavioral analysis-the use of modern methods from computer science and engineering to quantitatively measure animal behavior. We discuss aspects of experiment design important to both obtaining biologically relevant behavioral data and enabling the use of machine vision and learning techniques for automation. These two goals are often in conflict. Restraining or restricting the environment of the animal can simplify automatic behavior quantification, but it can also degrade the quality or alter important aspects of behavior...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27070552/neuronal-mechanisms-of-visual-categorization-an-abstract-view-on-decision-making
#13
David J Freedman, John A Assad
Categorization is our ability to flexibly assign sensory stimuli into discrete, behaviorally relevant groupings. Categorical decisions can be used to study decision making more generally by dissociating category identity of stimuli from the actions subjects use to signal their decisions. Here we discuss the evidence for such abstract categorical encoding in the primate brain and consider the relationship with other perceptual decision paradigms. Recent work on visual categorization has examined neuronal activity across a hierarchically organized network of cortical areas in monkeys trained to group visual stimuli into arbitrary categories...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27050321/ant-genetics-reproductive-physiology-worker-morphology-and-behavior
#14
D A Friedman, D M Gordon
Many exciting studies have begun to elucidate the genetics of the morphological and physiological diversity of ants, but as yet few studies have investigated the genetics of ant behavior directly. Ant genomes are marked by extreme rates of gene turnover, especially in gene families related to olfactory communication, such as the synthesis of cuticular hydrocarbons and the perception of environmental semiochemicals. Transcriptomic and epigenetic differences are apparent between reproductive and sterile females, males and females, and workers that differ in body size...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27050320/alzheimer-s-disease-mechanisms-and-emerging-roads-to-novel-therapeutics
#15
Carlo Sala Frigerio, Bart De Strooper
Ten years of remarkable progress in understanding the fundamental biochemistry of Alzheimer's disease have been followed by ten years of remarkable and increasing clinical insight into the natural progression of the disorder. The concept of a long, intermediary, prodromal phase between the first appearance of amyloid plaques and tangles and the manifestation of dementia is now well established. The major challenge for the next decade is to chart the many cellular processes that underlie this phase and link the biochemical alterations to the clinical manifestation of Alzheimer's disease...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27050319/clarifying-human-white-matter
#16
Brian A Wandell
Progress in magnetic resonance imaging (MRI) now makes it possible to identify the major white matter tracts in the living human brain. These tracts are important because they carry many of the signals communicated between different brain regions. MRI methods coupled with biophysical modeling can measure the tissue properties and structural features of the tracts that impact our ability to think, feel, and perceive. This review describes the fundamental ideas of the MRI methods used to identify the major white matter tracts in the living human brain...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27023732/beyond-the-cb1-receptor-is-cannabidiol-the-answer-for-disorders-of-motivation
#17
Natalie E Zlebnik, Joseph F Cheer
The Cannabis sativa plant has been used to treat various physiological and psychiatric conditions for millennia. Current research is focused on isolating potentially therapeutic chemical constituents from the plant for use in the treatment of many central nervous system disorders. Of particular interest is the primary nonpsychoactive constituent cannabidiol (CBD). Unlike Δ(9)-tetrahydrocannabinol (THC), CBD does not act through the cannabinoid type 1 (CB1) receptor but has many other receptor targets that may play a role in psychiatric disorders...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27023731/ten-years-of-grid-cells
#18
David C Rowland, Yasser Roudi, May-Britt Moser, Edvard I Moser
The medial entorhinal cortex (MEC) creates a neural representation of space through a set of functionally dedicated cell types: grid cells, border cells, head direction cells, and speed cells. Grid cells, the most abundant functional cell type in the MEC, have hexagonally arranged firing fields that tile the surface of the environment. These cells were discovered only in 2005, but after 10 years of investigation, we are beginning to understand how they are organized in the MEC network, how their periodic firing fields might be generated, how they are shaped by properties of the environment, and how they interact with the rest of the MEC network...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/27023730/human-spinal-motor-control
#19
Jens Bo Nielsen
Human studies in the past three decades have provided us with an emerging understanding of how cortical and spinal networks collaborate to ensure the vast repertoire of human behaviors. Humans have direct cortical connections to spinal motoneurons, which bypass spinal interneurons and exert a direct (willful) muscle control with the aid of a context-dependent integration of somatosensory and visual information at cortical level. However, spinal networks also play an important role. Sensory feedback through spinal circuitries is integrated with central motor commands and contributes importantly to the muscle activity underlying voluntary movements...
July 8, 2016: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/26154981/new-opportunities-in-vasopressin-and-oxytocin-research-a-perspective-from-the-amygdala
#20
REVIEW
Ron Stoop, Chloé Hegoburu, Erwin van den Burg
In the present review, we discuss how the evolution of oxytocin and vasopressin from a single ancestor peptide after gene duplication has stimulated the development of the vertebrate social brain. Separate production sites became possible with a hypothalamic development, which, interestingly, is triggered by the same transcription factors that underlie the development of various subcortical regions where vasopressin and oxytocin receptors are adjacently expressed and which are connected by inhibitory circuits...
July 8, 2015: Annual Review of Neuroscience
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