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Muscle & Nerve

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https://www.readbyqxmd.com/read/28646568/blink-r1-latency-utility-in-diagnosis-and-treatment-assessment-of-poems-and-cidp
#1
Wei Wang, William J Litchy, Michelle L Mauermann, P James B Dyck, Angela Dispenzieri, Jay Mandrekar, Peter J Dyck, Christopher J Klein
INTRODUCTION: In POEMS and CIDP, limb nerve conduction studies (NCS) are limited in identifying demyelination and detecting treatment effects in severely affected patients. Blink R1-latency may improve these assessments. METHODS: POEMS and CIDP patients having undergone NCS and blink reflex were identified. Correlations between R1-latency, limb NCS and neuropathy impairment scores (NIS) were compared. RESULTS: With182 patients (124 POEMS, 58 CIDP) identified, R1-prolongation (>13ms) occurred in 64...
June 23, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28646510/compound-muscle-action-potential-duration-in-critical-illness-neuromyopathy
#2
Christopher L Kramer, Andrea J Boon, C Michel Harper, Brent P Goodman
BACKGROUND: We sought to determine the specificity of compound muscle action potential (CMAP) durations and amplitudes in a large critical illness neuromyopathy (CINM) cohort relative to controls with other neuromuscular conditions. METHODS: Fifty-eight patients with CINM seen over a 17-year period were retrospectively studied. Electrodiagnostic findings of the CINM cohort were compared with patients with axonal peripheral neuropathy and myopathy due to other causes...
June 23, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28646486/editorial-on-ultrasonography-in-neuralgic-amyotrophy-sensitivity-spectrum-of-findings-and-clinical-correlations-by-ar%C3%A3-nyi-et-al
#3
EDITORIAL
Nens van Alfen
No abstract text is available yet for this article.
June 23, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28635099/effects-of-electronic-device-overuse-by-university-students-in-relation-to-clinical-status-and-anatomical-variations-of-the-median-nerve-and-transverse-carpal-ligament
#4
Eugenia Hoi Chi Woo, Peter White, Christopher Wai Keung Lai
INTRODUCTION: This study investigates the results of a questionnaire, provocative tests, and ultrasonographic measurements of carpal tunnel morphological parameters in intensive and nonintensive electronic device users. METHODS: Forty-eight university students (equal numbers of intensive and nonintensive users, ≥5 h/day and <5 h/day of electronic device usage, respectively) were randomly selected after questionnaire responses were received and evaluated clinically and by ultrasonography...
June 21, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28632967/prevalence-and-orthopedic-management-of-foot-and-ankle-deformities-in-charcot-marie-tooth-disease
#5
Matilde Laurá, Dishan Singh, Gita Ramdharry, Jasper Morrow, Mariola Skorupinska, Davide Pareyson, Joshua Burns, Richard A Lewis, Steve Scherer, David N Herrmann, Nicholas Cullen, Christopher Bradish, Luca Gaiani, Nicolò Martinelli, Paul Gibbons, Glenn Pfeffer, Phinit Phisitkul, Keith Wapner, James Sanders, Sam Flemister, Michael E Shy, Mary M Reilly
INTRODUCTION: Foot deformities are frequent complications in Charcot-Marie-Tooth disease (CMT) patients, often requiring orthopedic surgery. However there are no prospective randomized studies on surgical management, and there is variation in the approache between centers in the same country and between different countries. METHODS: We assessed the frequency of foot deformities and surgery among patients recruited to the Inherited Neuropathies Consortium (INC). We also designed a survey addressed to orthopedic surgeons at INC centers to determine whether surgical approaches to orthopedic complications in CMT are variable...
June 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28632945/developing-multidisciplinary-clinics-for-neuromuscular-care-and-research
#6
REVIEW
Sabrina Paganoni, Katie Nicholson, Fawn Leigh, Kathryn Swoboda, David Chad, Kristin Drake, Kellen Haley, Merit Cudkowicz, James D Berry
Multidisciplinary care is considered the standard-of-care for both adult and pediatric neuromuscular disorders and has been associated with improved quality of life, resource utilization, and health outcomes. Multidisciplinary care is delivered in multidisciplinary clinics that coordinate care across multiple specialties reducing travel burden and streamlining care. In addition, multidisciplinary care setting facilitates the integration of clinical research, patient advocacy, and care innovation (e.g., TeleHealth)...
June 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28632919/isolated-facial-palsy-from-perineural-spread-of-cutaneous-squamous-cell-carcinoma
#7
Arens Taga, Filippo Di Lella, Luigi Corcione, Giovanni Pavesi
No abstract text is available yet for this article.
June 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28632904/ngf-and-fgf-2-promote-reinnervation-by-nerve-muscle-endplate-grafting
#8
Liancai Mu, Stanislaw Sobotka, Jingming Chen, Themba Nyirenda
INTRODUCTION: This study was designed to test whether exogenous application of nerve growth factor (NGF) and basic fibroblast growth factor (FGF-2) to muscles reinnervated with nerve-muscle-endplate band grafting (NMEG) could promote specific outcomes. METHODS: The right sternomastoid muscle in adult rats was experimentally denervated and immediately reinnervated by implanting a NMEG pedicle from the ipsilateral sternohyoid muscle. A fibrin sealant containing NGF and FGF-2 was focally applied to the implantation site...
June 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28632896/reliability-of-a-novel-approach-for-quadriceps-motor-point-assessment
#9
Ada Weiss, Neal R Glaviano, Jacob Resch, Susan Saliba
INTRODUCTION: We studied the ability of clinicians to identify quadriceps motor points using a transcutaneous electrical stimulation unit(TENS). METHODS: Twenty-two certified athletic trainers and one expert-rater identified the seven motor points of the quadriceps at two time points separated by one week. The difference was calculated between where each participant and the expert-rater identified each motor point using an x-y coordinate system. Bland-Altman plots were used to compare differences between two testing sessions...
June 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28622409/ultrasound-guided-hydrodissection-decreases-gliding-resistance-of-the-median-nerve-within-the-carpal-tunnel
#10
Stefanie Evers, Andrew R Thoreson, Jay Smith, Chunfeng Zhao, Jennifer R Geske, Peter C Amadio
INTRODUCTION: The aim of this study was to assess alterations in median nerve biomechanics within the carpal tunnel resulting from ultrasound-guided hydrodissection in a cadaveric model. METHODS: Twelve fresh frozen human cadaver hands were used. Median nerve gliding resistance was measured at baseline and post-hydrodissection, by pulling the nerve proximally and then returning it to the origin. Six specimens were treated with hydrodissection, and 6 were used as controls...
June 16, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28621464/differences-in-excitability-properties-between-mg-ta-and-apb-motor-axons
#11
Cliff S Klein, Chen Ning Zhao, Hui Liu, Ping Zhou
INTRODUCTION: Excitability properties of motor nerves to different muscles are different, but the explanation is uncertain. We characterized motor axon excitability properties to the medial gastrocnemius (MG) in 27 adults, and made comparisons with the peroneal nerve to the tibialis anterior (TA) and median nerve to the abductor pollicis brevis (APB) in 10 subjects. METHODS: Recordings of multiple excitability properties were made using threshold tracking, stimulating the nerves at the wrist or knee...
June 16, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28590545/the-utility-of-a-single-simple-question-in-the-evaluation-of-patients-with-myasthenia-gravis
#12
Alon Abraham, Ari Breiner, Carolina Barnett, Hans D Katzberg, Vera Bril
INTRODUCTION: Assessing myasthenia gravis (MG) can be challenging, and multiple scales are available to evaluate disease severity. We evaluated the utility of a single simple question, namely "what percentage of normal do you feel regarding your MG, 0-100% normal", as part of the MG evaluation. METHODS: A retrospective chart review of patients attending the neuromuscular clinic from 01/2014 to 12/2015 was performed. Responses were correlated with symptoms and signs, QMGS (quantitative myasthenia gravis score), MGII (myasthenia gravis impairment index), and MG-QOL15 (myasthenia gravis quality of life)...
June 7, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28590525/effects-of-repeated-abobotulinumtoxina-injections-in-upper-limb-spasticity
#13
Jean-Michel Gracies, Michael O'Dell, Michele Vecchio, Peter Hedera, Serdar Kocer, Monika Rudzinska-Bar, Bruce Rubin, Sofiya L Timerbaeva, Anna Lusakowska, François Constant Boyer, Anne-Sophie Grandoulier, Claire Vilain, Philippe Picaut
INTRODUCTION: The efficacy of single injections of abobotulinumtoxinA (Dysport®) is established in adults with upper limb spasticity. This study aimed to assess the effects of repeated injections of abobotulinumtoxinA over 1 year. METHODS: Patients (n=258 safety population) received 500U, 1000U or 1500U (1500U dose included 500U shoulder injections) for up to 4 or 5 treatment cycles. Assessments included treatment-emergent adverse events (TEAEs), muscle tone, passive and active range of motion (XV1, XA ), angle of catch (XV3 ), Disability Assessment Scale (DAS), Modified Frenchay Scale (MFS) and Physician Global Assessment (PGA)...
June 7, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28590524/work-related-carpal-tunnel-syndrome-what-s-important
#14
EDITORIAL
Gary M Franklin, Zachary Gray
No abstract text is available yet for this article.
June 7, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28561992/reply
#15
LETTER
Elliot Bodofsky, Gregory T Carter, John D England
No abstract text is available yet for this article.
May 31, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28561932/lenalidomide-responsive-anti-mag-neuropathy
#16
Amro M Stino, Yvonne Efebera
No abstract text is available yet for this article.
May 31, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28561927/mononeuritis-multiplex-associated-with-minocycline-in-an-adolescent
#17
EDITORIAL
Hugh J McMillan, Gerard H Jansen, Khaldoun Koujok, Nataliya Milman, Ciarán M Duffy, Karen Watanabe Duffy
No abstract text is available yet for this article.
May 31, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28561926/quantitative-sonographic-assessment-of-myotonia
#18
Alon Abraham, Ari Breiner, Carolina Barnett, Vera Bril, Hans D Katzberg
INTRODUCTION: The goal of this study was to explore ultrasound imaging for qualitative and quantitative assessment of myotonia. METHODS: 16 patients with myotonia and 16 controls underwent sonographic evaluation of the thenar eminence muscles to assess the relaxation time after muscle percussion. RESULTS: The mean time for complete muscle relaxation in patients with myotonia was longer than that of controls. A cut-off of >0.9 seconds for myotonia detection had a sensitivity of 88% and a specificity of 100%...
May 31, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28561925/evolution-of-sensory-neuropathy-after-initiation-of-antiretroviral-therapy
#19
Chad M Centner, Francesca Little, Johan J van der Watt, John-Randel Vermaak, Joel A Dave, Naomi S Levitt, Jeannine M Heckmann
INTRODUCTION: We studied the evolution of sensory neuropathy after antiretroviral therapy (ART) in HIV-infected South Africans. METHODS: Enrolment commenced before ART with 6-monthly follow-up for 24 months. Symptomatic distal sensory polyneuropathy (SDSP) was defined as one symptom and sign. Symptom/sign scores were compared between visits. RESULTS: We enrolled 184 participants. Pre-ART, 16% had SDSP. After 18 months of ART, pain prevalence decreased in those with pre-ART SDSP (odds ratio [OR] 0...
May 31, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28561923/quantification-and-characterization-of-grouped-type-i-myofibers-in-human-aging
#20
Neil A Kelly, Kelley G Hammond, Michael J Stec, C Scott Bickel, Samuel T Windham, S Craig Tuggle, Marcas M Bamman
INTRODUCTION: Myofiber type grouping is a histological hallmark of age-related motor unit remodeling. Despite the accepted concept that denervation-reinnervation events lead to myofiber type grouping, the completeness of those conversions remains unknown. METHODS: Type I myofiber grouping was assessed in vastus lateralis biopsies from Young (26 ± 4 yrs, n = 27) and Older (66 ± 4 yrs, n = 91) adults. Grouped and ungrouped type I myofibers were evaluated for phenotypic differences...
May 31, 2017: Muscle & Nerve
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