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Muscle & Nerve

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https://www.readbyqxmd.com/read/30447091/optimal-needle-placement-for-extensor-hallucis-longus-muscle-using-ultrasound-verification
#1
Jin Myoung Kwak, Dong Hyun Kim, Yang Gyun Lee, Yoon-Hee Choi
INTRODUCTION: The extensor hallucis longus (EHL) muscle is important for diagnosis of neurologic lesions. It is also a target muscle for treatment. We investigated EHL with ultrasonography to determine optimal needle placement for safety and accuracy. METHODS: A total of 96 legs of 48 healthy volunteers were examined through ultrasonography. Four published electromyographic (EMG) methods for finding the EHL were assessed. We identified the midpoint of EHL (MD) using landmarks to determine optimal needle placement...
November 17, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30447080/increased-risk-of-melanoma-in-c9orf72-repeat-expansion-carriers-a-case-control-study
#2
Miguel Tábuas-Pereira, Luciano Almendra, Maria Rosário Almeida, João Durães, André Pinho, Anabela Matos, Luis Negrão, Argemiro Geraldo, Isabel Santana
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are considered part of the same pathological spectrum. There is an increased risk of ALS in patients who have had melanoma. The risk of FTLD in melanoma (or cancer) patients is unknown. We aimed to study if C9ORF72 expansion is linked to a higher prevalence of melanoma. METHODS: We selected patients with a diagnosis in the ALS-FTLD spectrum who were tested for pathogenic mutations...
November 17, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30414326/needle-electromyography-and-histopathologic-correlation-in-myopathies
#3
Ugur Sener, Jennifer Martinez-Thompson, Ruple S Laughlin, Elliot L Dimberg, Devon I Rubin
INTRODUCTION: Needle electromyography (EMG) findings help confirm myopathy and may indicate specific pathologic changes on muscle biopsy. METHODS: Retrospective chart review of 218 consecutive patients referred for muscle biopsy. Presence of specific needle EMG findings was correlated to pathologic findings of inflammation, necrosis, splitting, and vacuolar changes. Sensitivity, specificity, and positive and negative predictive values of specific EMG findings for pathologic changes were calculated...
November 10, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30414324/health-maintenance-for-adults-with-neuromuscular-diseases-on-immunosuppression
#4
REVIEW
Sarah L Cartwright, Michael S Cartwright
Immunosuppressants are commonly used in the treatment of neuromuscular diseases. The use of these medications requires health maintenance screening and monitoring for multiple potential sides effects, which may be best conducted when the prescribing physician and primary care physician work in tandem. Clinical practice guidelines, recommendations from professional organizations, prescription drug labeling, and expert opinion were reviewed and combined to provide recommendations for health maintenance for eight different immunosuppressants...
November 10, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30414322/clinical-and-electrodiagnostic-features-of-non-traumatic-sciatic-neuropathy
#5
Rejo P Cherian, Yuebing Li
INTRODUCTION: We sought to characterize etiologies and features of sciatic neuropathy unrelated to penetrating nerve trauma. METHODS: A retrospective review of 109 patients with electrodiagnostically confirmed sciatic neuropathies. RESULTS: Hip replacement surgery represented the most common (34.9%) etiology, while inflammatory sciatic neuropathy was seen in 7.3%. Electrodiagnostic testing revealed an axonal neuropathy in 95.4% and a demyelinating neuropathy in 4...
November 10, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30414320/effects-of-treadmill-training-on-microvascular-remodeling-in-the-rat-following-spinal-cord-injury
#6
Roger W P Kissane, Oliver Wright, Yazi D Al'Joboori, Paulina Marczak, Ronaldo M Ichiyama, Stuart Egginton
INTRODUCTION: The morphological characteristics of skeletal muscles innervated caudal to a spinal cord injury (SCI) undergo dramatic phenotypic and microvascular changes. METHOD: Female Sprague Dawley rats received a severe contusion at thoracic level 9/10, and were randomly assigned to locomotor training (TR), epidural stimulation (ES) or a combination of the treatment groups (CB). Fibre type composition and capillary distribution were assessed in phenotypically distinct compartments of the tibialis anterior...
November 10, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30412272/novel-speg-mutations-in-congenital-myopathies-genotype-phenotype-correlations
#7
Anita E Qualls, Sandra Donkervoort, Johanna C Herkert, Alissa M D'Gama, Diana Bharucha-Goebel, James Collins, Katherine R Chao, A Reghan Foley, Mirthe H Schoots, Jan D H Jongbloed, Carsten G Bönnemann, Pankaj B Agrawal
INTRODUCTION: Centronuclear myopathies (CNMs) are a subtype of congenital myopathies (CMs) characterized by muscle weakness, predominant type 1 fibers, and increased central nuclei. SPEG (striated preferentially expressed protein kinase) mutations have recently been identified in seven CM patients (six with CNMs). We report two additional patients with SPEG mutations expanding the phenotype and evaluate genotype-phenotype correlations associated with SPEG mutations. METHODS/RESULTS: Using whole exome/genome sequencing in CM families, we identified novel recessive SPEG mutations in two patients...
November 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30390398/vibration-testing-optimising-methods-to-improve-reliability
#8
Anna Marcuzzi, Alan C Wainwright, Daniel Sj Costa, Paul J Wrigley
INTRODUCTION: This study aimed to assess the test-retest reliability of a Rydel-Seiffer tuning fork and an electronic vibrameter with hand-held and fixed probes. METHODS: Fifty healthy volunteers were assessed twice in the upper and lower limb 15 minutes apart. Reliability was assessed by intraclass correlation coefficients (ICC) and standard error of measurement (SEM). The effect of stimulus parameters on vibration disappearance threshold (VDT) was assessed by analysis of variance...
November 3, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30390396/the-correlation-of-ultrasound-cross-sectional-area-of-the-median-nerve-nerve-conduction-studies-and-two-point-discrimination
#9
Georgios N Panagopoulos, Tiffany Wu, John R Fowler
INTRODUCTION: The purpose of this study was to determine the correlation between a measure of physical performance, a measure of physiology and a measure of anatomy in the setting of carpal tunnel syndrome (CTS). METHODS: A retrospective review of 215 consecutive patients with suspected CTS was conducted. All patients were evaluated with static two-point discrimination (2PD), ultrasound (US) measurement of the median nerve cross-sectional area (CSA) and nerve conduction studies (NCS)...
November 3, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30390395/open-label-trial-of-ranolazine-for-the-treatment-of-paramyotonia-congenita
#10
Samantha LoRusso, David Kline, Amy Bartlett, Miriam Freimer, Julie Agriesti, Ahmed A Hawash, Mark M Rich, John T Kissel, W David Arnold
INTRODUCTION: Paramyotonia congenita (PMC) is a non-dystrophic myotonic disorder that is believed to be caused by a defect in Nav 1.4 sodium channel inactivation. Ranolazine, which acts by enhancing slow inactivation of sodium channels, has been proposed as a therapeutic option, but in vivo studies are lacking. METHODS: We conducted an open-label, single-center trial of ranolazine to evaluate efficacy and tolerability in patients with PMC. Subjective symptoms of stiffness, weakness, and pain, as well as clinical and electrical myotonia, were evaluated...
November 3, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30390392/ultrasonographic-evaluation-of-radial-nerve-injuries-associated-with-pediatric-chronic-monteggia-lesions
#11
Weiyong Liu, Xiufang Sui, Lei Ye, Li Zhao
INTRODUCTION: To determine the ultrasonographic evaluation of radial nerve (RN) before correction of chronic pediatric Monteggia lesions in patients with suspected nerve injury. METHOD: Twelve consecutive children with Monteggia lesions were investigated. The cross-sectional area (CSA) of the nerve and nerve to skin (N-S) distance were determined by ultrasonography at three levels: 5 cm proximal to humeroradial joint (L_prox), horizontal line through humeroradial joint (L_mid), and 2...
November 3, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30390307/intubation-tracheostomy-and-decannulation-in-gbs-patients-does-dysphagia-matter
#12
Jens Burchard Schröder, Thomas Marian, Paul Muhle, Inga Claus, Christian Thomas, Tobias Ruck, Heinz Wiendl, Tobias Warnecke, Sonja Suntrup-Krueger, Sven Meuth, Rainer Dziewas
INTRODUCTION: Although patients with Guillain-Barré-Syndrome frequently require orotracheal intubation and tracheostomy, the incidence and relevance of neurogenic dysphagia prior to intubation and risk factors for prolonged need for a tracheal cannula, have not yet been identified. METHODS: Retrospective analysis of the medical records of 88 patients was performed. Clinical characteristics were compared between intubated and non-intubated, and between immediately decannulated and not immediately decannulated patients...
November 2, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30390296/a-child-with-antibody-negative-immune-mediated-necrotizing-myopathy
#13
Cemal Karakas, Jeetendra Sah, Roberta Seidman, Geetha Chari, Yoshimi Hisamoto, Joan Cracco, Alexandra Reznikov, Radha Giridharan, Yaacov Anziska
No abstract text is available yet for this article.
November 2, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30383311/artifact-from-notch-filter
#14
LETTER
Sanjeev D Nandedkar
No abstract text is available yet for this article.
November 1, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30383297/in-response-to-study-of-serum-microrna-expression-in-amyotrophic-lateral-sclerosis-patients-the-challenge-of-selecting-suitable-internal-control-for-normalization
#15
LETTER
Radhika Raheja, Keren Regev, Brian C Healy
No abstract text is available yet for this article.
November 1, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30383294/study-of-serum-microrna-expression-in-amyotrophic-lateral-sclerosis-patient-the-challenge-of-selecting-suitable-internal-control-for-normalization
#16
LETTER
Soheil Madadi, Meysam Soleimani
No abstract text is available yet for this article.
November 1, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30376690/forearm-predominant-para-infectious-myositis
#17
James Triplett, Louise Rigney, Todd A Hardy, Yael Barnett, Michael W Hayes, Michael Barnett, Stephen W Reddel
BACKGROUND: Focal post-viral or para-infectious myositis with preponderance for the calves was first reported in children while generalized para and post-viral acute myositis has also been reported in the elderly. RESULTS: We report a series of 9 adult males who presented with upper limb myositis and presumed intercurrent viral infection. Symptom duration ranged from 4-21 days, and weakness was found to preferentially affect the flexor compartment of the forearms...
October 30, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30370671/muscle-contractility-dysfunction-precedes-loss-of-motor-unit-connectivity-in-sod1-g93a-mice
#18
Christopher G Wier, Alexander E Crum, Anthony B Reynolds, Chitra C Iyer, Deepti Chugh, Marilly S Palettas, Patrick L Heilman, David M Kline, W David Arnold, Stephen J Kolb
INTRODUCTION: Electrophysiological measurements are used in longitudinal clinical studies to provide insight into the progression of amyotrophic lateral sclerosis (ALS) and the relationship between muscle weakness and motor unit degeneration. Here, we used a similar longitudinal approach in the SOD1(G93A) mouse model of ALS. METHODS: In vivo muscle contractility and motor unit connectivity assays were assessed longitudinally in SOD1(G93A) and wildtype mice from post-natal day 35 to 119...
October 28, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30370536/optimal-e2-reference-electrode-placement-in-fibular-motor-nerve-conduction-studies-recording-from-the-tibialis-anterior-muscle
#19
Marcio Luiz Escorcio-Bezerra, Agessandro Abrahao, Karlo Faria Nunes, Fabio Veiga de Castro Sparapani, Nadia Iandoli de Oliveira Braga, Lawrence R Robinson, Lorne Zinman, Gilberto Mastrocola Manzano
INTRODUCTION: We aimed to determine the contribution of the E2 (reference electrode) to the compound muscle action potential (CMAP) amplitude during fibular motor recording to the tibialis anterior (TA) when E2 is placed over routine referential v. alternative sites. METHODS: The CMAP was obtained from 10 healthy subjects, using the active electrode (E1) over sites routinely used as E2 for the TA, while the E2 was over the contralateral knee. The same procedure was performed with the E1 over alternative E2 sites...
October 28, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/30367493/e-norms-reply
#20
LETTER
Joe F Jabre
No abstract text is available yet for this article.
October 26, 2018: Muscle & Nerve
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