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Muscle & Nerve

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https://www.readbyqxmd.com/read/29790193/myasthenic-ophthalmoparesis-time-to-resolution-after-initiating-immune-therapies
#1
T A Europa, M Nel, J M Heckmann
INTRODUCTION: Although immunotherapies such as prednisone are effective in treating myasthenic muscle weakness, their effect on resolution of myasthenic-induced persistent ophthalmoparesis is unknown. METHODS: We observed myasthenia gravis patients during their first year of immunotherapy, documenting ophthalmoplegia scores and drug doses. RESULTS: Seventy-six of 87 cases had persistent ophthalmoparesis. On immunotherapy, the median time to resolution of ophthalmoparesis was 7 months and 37% resolved within 3 months...
May 23, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29781124/sonographic-median-nerve-change-after-steroid-injection-for-carpal-tunnel-syndrome
#2
Jia-Chi Wang, Kon-Ping Lin, Kwong-Kum Liao, Yue-Cune Chang, Kevin A Wang, Yu-Fang Huang, Jan-Wei Chiu
Introduction The sonographic changes of the median nerve after steroid injection for carpal tunnel syndrome (CTS) still require investigation. Methods Sixty-two patients with CTS were included. The Boston Carpal Tunnel Questionnaire was administered and ultrasonographic examinations were performed before and at 2, 6, and 12 weeks after steroid injection. At 12 weeks, general improvement was scored on a 6-point Likert scale. Results After treatment, the cross-sectional area (CSA) of the median nerve was significantly reduced at 2, 6, and 12 weeks follow-up (for each, Pā€‰<ā€‰...
May 20, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29752826/post-polio-syndrome-and-the-late-effects-of-poliomyelitis-part-2-treatment-management-and-prognosis
#3
REVIEW
Julian K Lo, Lawrence R Robinson
Post-Polio Syndrome (PPS) is characterized by new muscle weakness and/or muscle fatigability that occurs many years following the initial poliomyelitis illness. An individualized approach to rehabilitation management is critical. Interventions may include rehabilitation management strategies, adaptive equipment, orthotic equipment, gait/mobility aids and a variety of therapeutic exercises. The progression of muscle weakness in PPS is typically slow and gradual; however, there is also variability in both the natural history of weakness and functional prognosis...
May 12, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29752819/post-polio-syndrome-and-the-late-effects-of-poliomyelitis-part-1-pathogenesis-biomechanical-considerations-diagnosis-and-investigations
#4
REVIEW
Julian K Lo, Lawrence R Robinson
Post-Polio Syndrome (PPS) is characterized by new muscle weakness and/or muscle fatigability that occurs many years following the initial poliomyelitis illness. There are many theories that exist on the pathogenesis of PPS, which remains incompletely understood. In contrast, the Late Effects of Poliomyelitis are often a consequence of biomechanical alterations that occur as a result of polio-related surgeries, musculoskeletal deformities or weakness. Osteoporosis and fractures of the polio-involved limbs are common...
May 12, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29752813/the-long-exercise-test-in-periodic-paralysis-a-bayesian-analysis
#5
Daniel B Simmons, Julie Lanning, James C Cleland, Araya Puwanant, Paul T Twydell, Robert C Griggs, Rabi Tawil, Eric L Logigian
INTRODUCTION: The long exercise test (LET) is used to assess the diagnosis of periodic paralysis (PP), but LET methodology and normal "cut-off" values vary. METHODS: To determine optimal LET methodology and cut-offs, we reviewed LET data (abductor digiti minimi (ADM) motor response amplitude, area) from 55 PP patients (32 genetically definite) and 125 controls. Receiver operating characteristic (ROC) curves were constructed and area-under-the-curve (AUC) calculated to compare 1) peak-to-nadir versus baseline-to-nadir methodologies, and 2) amplitude versus area decrements...
May 12, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29742813/mutated-cancer-autoantigen-implicated-cause-of-paraneoplastic-myasthenia-gravis
#6
Anastasia Zekeridou, Guy E Griesmann, Vanda A Lennon
INTRODUCTION: Anti-tumor immune responses are postulated to initiate paraneoplastic neurological disorders when proteins normally restricted to neural cells are expressed as oncoproteins. Mutated oncopeptides could bypass self-tolerant T-cells to activate cytotoxic effector T-lymphocytes and requisite helper T-lymphocytes to stimulate autoantibody production by B-lymphocytes. METHODS: We investigated muscle-type nicotinic acetylcholine receptor (AChR) antigen expression at transcriptional and protein levels in a small-cell lung cancer line (SCLC) established from a patient with AChR-IgG-positive myasthenia gravis...
May 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29742807/bet-on-autophagy-in-the-race-against-muscular-dystrophies
#7
EDITORIAL
Giorgia Catarinella, Lucia Latella
No abstract text is available yet for this article.
May 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29742802/a-case-of-acute-onset-multifocal-motor-neuropathy-after-mycoplasma-infection
#8
Daisuke Nakashima, Yu-Ichi Noto, Yukiko Tsuji, Chihiro Fujii, Akihiro Tanaka, Tomoyuki Ohara, Masanori Nakagawa, Toshiki Mizuno
No abstract text is available yet for this article.
May 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29742800/reductions-in-muscle-quality-and-quantity-in-cidp-patients-assessed-by-magnetic-resonance-imaging
#9
Kevin J Gilmore, Timothy J Doherty, Kurt Kimpinski, Charles L Rice
INTRODUCTION: Weakness in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) may be caused by decreases in muscle quantity and quality, but these have not been explored. METHODS: Twelve patients with CIDP (mean 61 years) and ten age- matched (mean 59 years) control subjects were assessed for ankle dorsiflexion strength, and two different MRI scans (T1 and T2) of leg musculature. RESULTS: Isometric strength was lower in CIDP patients by 36% compared with controls...
May 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29742798/longitudinal-timed-function-tests-in-duchenne-muscular-dystrophy-imagingdmd-cohort-natural-history
#10
Harneet Arora, Rebecca J Willcocks, Donovan J Lott, Ann T Harrington, Claudia R Senesac, Kirsten L Zilke, Michael J Daniels, Dandan Xu, Gihan I Tennekoon, Erika L Finanger, Barry S Russman, Richard S Finkel, William T Triplett, Barry J Byrne, Glenn A Walter, H Lee Sweeney, Krista Vandenborne
INTRODUCTION: Tests of ambulatory function are common clinical trial endpoints in Duchenne muscular dystrophy (DMD). The ImagingDMD study has generated a large data set using these tests, which can describe the contemporary natural history of DMD in 5-12.9 year olds. METHODS: 92 corticosteroid treated boys with DMD and 45 controls participated in this longitudinal study. Subjects performed the 6 minute walk test (6MWT) and timed function tests (TFTs: 10m walk/run, 4 stairs, supine to stand)...
May 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29742797/distal-predominance-of-electrodiagnostic-abnormalities-in-early-stage-amyotrophic-lateral-sclerosis
#11
Luay Shayya, Suma Babu, Erik P Pioro, Jianbo Li, Yuebing Li
INTRODUCTION: We compare the electrodiagnostic (EDX) yield of limb muscles in revealing lower motor neuron (LMN) dysfunction by electromyography (EMG) in early stage amyotrophic lateral sclerosis (ALS). METHODS: Single-site retrospective review Results: This study includes 122 consecutive patients with possible ALS as defined by revised El Escorial Criteria. Distal limb muscles show more frequent EMG abnormalities than proximal muscles. EDX yield is higher in the limb where weakness begins and when clinical signs of LMN dysfunction are evident...
May 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29742796/hdac-inhibition-inhibits-brachial-plexus-avulsion-induced-neuropathic-pain
#12
Yingbo Zhao, Tianjian Wu
Introduction Neuropathic pain induced by brachial plexus avulsion (BPA) is a pathological condition. We hypothesized that inhibition of histone deacetylase (HDAC) could suppress BPA-induced neuropathic pain through inhibition of transient reception potential (TRP) overexpression and protein kinase B (Akt) mediated mammalian target of rapamycin (mTOR) activation. Methods We generated a rat BPA model, administered HDAC inhibitor Tricostatin A (TSA) for 7 days post-surgery and assessed the effects on HDAC expression, Akt phosphorylation, neuroinflammation and mTOR activation...
May 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29742795/rituximab-in-refractory-myasthenia-gravis-extended-prospective-study-results
#13
Grayson Beecher, Dustin Anderson, Zaeem A Siddiqi
INTRODUCTION: Rituximab appears beneficial in treatment-refractory myasthenia gravis (MG), however, prospective, long-term durability data is lacking. METHODS: In this prospective, open-label study of rituximab in refractory MG, 22 patients (10 AChR, 9 MuSK, 3 seronegative) received rituximab at baseline, with repeat cycles driven by clinical worsening. Manual muscle testing (MMT) scores and CD19/CD20+ B cell counts were serially monitored. RESULTS: At mean follow-up of 28...
May 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29742794/clinical-outcome-assessments-the-rasch-ionale-for-improved-accuracy
#14
EDITORIAL
Pushpa Narayanaswami, Ted M Burns
No abstract text is available yet for this article.
May 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29742793/adipose-derived-stem-cells-from-mice-to-man
#15
EDITORIAL
K Ming Chan, Julie Beveridge, Christine A Webber
No abstract text is available yet for this article.
May 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29742792/building-a-better-munix-new-and-improved-but-does-it-hit-the-mark
#16
EDITORIAL
Clifton L Gooch
No abstract text is available yet for this article.
May 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29742791/the-prognosis-of-electrodiagnosis
#17
EDITORIAL
Johanna Hamel, Eric L Logigian
No abstract text is available yet for this article.
May 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29684239/correlation-between-mg-adl-and-qmg-assessments-of-anti-acetylcholine-receptor-antibody-positive-refractory-generalized-myasthenia-gravis-in-the-phase-3-regain-study
#18
LETTER
John Vissing, Fanny O'Brien, Jing Jing Wang, James F Howard
No abstract text is available yet for this article.
April 23, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29679393/neuromuscular-ultrasound-findings-in-eosinophilic-fasciitis-a-case-series-and-literature-review
#19
Michael Verenes, Sarah L Stone, Lisa D Hobson-Webb, Justin T Mhoon, Amanda C Guidon, Carolina De Jesus-Acosta, Michael S Cartwright
No abstract text is available yet for this article.
April 20, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29679379/how-can-we-best-estimate-the-incidence-and-prevalence-of-carpal-tunnel-syndrome
#20
EDITORIAL
Robert A Werner, Alfred Franzblau
No abstract text is available yet for this article.
April 20, 2018: Muscle & Nerve
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