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Muscle & Nerve

Aidan A Levine, Todd D Levine, Kathie Clarke, David Saperstein
INTRODUCTION: For patients receiving intravenous immunoglobulin (IVIG), renal and hemolytic side effects are well recognized. However, there is very little data on the effects of chronic IVIG therapy. METHODS: We retrospectively analyzed laboratory data on 166 patients who received IVIG for 12 months with dosing from 0.441 gm/kg/month to 2.58 gm/kg/month, measuring changes in hematocrit and glomerular filtration rates (GFR) at 6 and 12 months. RESULTS: Of the 2,232 infusions, there were no incidents of clinical hemolysis...
May 18, 2017: Muscle & Nerve
Hélio da V Cabral, Leonardo M L de Souza, Roger G T Mello, Alessio Gallina, Liliam F de Oliveira, Taian M Vieira
INTRODUCTION: Previous evidence suggests the fibres of different motor units reside within distinct vastus medialis (VM) regions. Whether the activity of these motor units may be modulated differently remains unknown. Here we assess the discharge rate of motor units detected proximo-distally from VM to address this issue. METHODS: Surface electromyograms (EMGs) were recorded proximally and distally from VM while ten healthy subjects performed isometric contractions...
May 13, 2017: Muscle & Nerve
Michael Vaeggemose, Signe Vaeth, Mirko Pham, Steffen Ringgaard, Uffe B Jensen, Hatice Tankisi, Niels Ejskjaer, Sabine Heiland, Henning Andersen
INTRODUCTION: Investigation of peripheral neuropathies by magnetic resonance neurography (MRN) may provide increased diagnostic accuracy when performed in combination with diffusion tensor imaging (DTI). The aim of this study was to evaluate DTI in the detection of neuropathic abnormalities in Charcot-Marie-Tooth-type-1A (CMT1A). METHODS: MR imaging of the sciatic and tibial nerves, including MRN and DTI, was prospectively performed in 15 CMT1A patients and 30 healthy-controls (HC)...
May 13, 2017: Muscle & Nerve
Matthew S Thiese, Andrew Merryweather, Alzina Koric, Ulrike Ott, Eric M Wood, Jay Kapellusch, James Foster, Arun Garg, Gwen Deckow-Schaeffer, Suzanna Tomich, Richard Kendall, David L Drury, Jacqueline Wertsch, Kurt T Hegmann
INTRODUCTION: Prior studies reported higher wrist ratios (WR) related to carpal tunnel syndrome (CTS), but have not assessed effect modification by obesity and may have inadequately controlled for confounders. METHODS: Baseline data of a multicenter prospective cohort study were analyzed. CTS was defined by nerve conduction study (NCS) criteria and symptoms. RESULTS: Among the 1,206 participants, a square-shaped wrist was associated with CTS after controlling for confounders (prevalence ratio = 2...
May 13, 2017: Muscle & Nerve
Vaidas Verbickas, Sigitas Kamandulis, Audrius Snieckus, Tomas Venckunas, Neringa Baranauskiene, Marius Brazaitis, Danguole Satkunskiene, Alvydas Unikauskas, Albertas Skurvydas
INTRODUCTION: The aim of this study was to follow circulating brain-derived neurotrophic factor (BDNF) and interleukin 6 (IL-6) levels in response to severe muscle-damaging exercise. METHODS: Young healthy men (N=10) performed a bout of mechanically demanding stretch shortening cycle exercise consisting of 200 drop jumps. Voluntary and electrically induced knee extension torque, serum BDNF levels, and IL-6 levels were measured before and for up to 7 days after exercise...
May 13, 2017: Muscle & Nerve
Brin Freund, Lindsey Hayes, Lucia Rivera-Lara, Charlotte Sumner, Vinay Chaudhry, Kevin Chatham-Stephens, Katharine Benedict, Suzanne Kalb, David Blythe, Richard Brooks, John C Probasco
No abstract text is available yet for this article.
May 13, 2017: Muscle & Nerve
Ludo van Hillegondsberg, Jonathan Carr, Naeem Brey, Franclo Henning
OBJECTIVE: To determine whether the use of Eulerian Video Magnification (EVM) increases the detection of muscle fasciculations in people with ALS (PALS), compared to direct clinical observation (DCO). METHODS: Thirty-second long video recordings were made of nine body regions of seven PALS and seven controls, and fasciculations were counted by DCO during the same thirty-second period. The video recordings were then motion-magnified and reviewed by two independent assessors...
May 13, 2017: Muscle & Nerve
Gorana Capkun, Aoife Callan, Haijun Tian, Zhongyuan Wei, Changgeng Zhao, Neetu Agashivala, Victoria Barghout
INTRODUCTION: We analyzed the burden of illness of sporadic Inclusion Body Myositis (sIBM) patients and the costs to the healthcare system. METHODS: A retrospective cohort analysis of 333 sIBM patients aged ≥50 years was performed using United States claims data. sIBM patients were matched in a 1:5 ratio to randomly selected individuals with ≥1 healthcare encounter within the year of index date. RESULTS: sIBM patients presented with higher rates of disease- and muscle-related conditions, such as myalgia, myositis, muscle weakness, dysphagia, pneumonia and falls...
May 10, 2017: Muscle & Nerve
Matthew C Pitt
A screening test is needed to diagnose disorders of the neuromuscular junction (NMJ) in children. This article describes the development of Stimulation Potential Analysis with Concentric needle Electrodes under the acronym SPACE. This nomenclature was chosen to distinguish the technique from single fibre methodology because of the difficulties in identifying single fibre potentials in most studies, particularly those with the most severe abnormalities of the NMJ. Performed on orbicularis oculi in children with proven or probable disorders of the NMJ, it demonstrated a sensitivity of 84%, specificity of 71%, negative predictive value of 95% and positive predictive value of 36%...
May 8, 2017: Muscle & Nerve
Hyunjin Kim, Young-Min Lim, Joo Yea Jin, Dok Hyun Yoon, Cheolwon Suh, Sun-Young Kim, Jae-Cheol Jo, Kwang-Kuk Kim
INTRODUCTION: Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome and monoclonal gammopathy of undetermined significance (MGUS) are paraproteinemic disorders that can cause demyelinating polyneuropathy. Here, we assessed the findings of nerve conduction studies (NCSs) in patients with POEMS syndrome and MGUS-related neuropathy to determine whether the NCS characteristics can help differentiate between the conditions. METHODS: We enrolled 24 POEMS and 37 MGUS-related neuropathy patients...
May 4, 2017: Muscle & Nerve
Edward J Kasarskis
Submitted are editorial comments and implications of the above-captioned research manuscript This article is protected by copyright. All rights reserved.
May 4, 2017: Muscle & Nerve
Stefanie Schreiber, Grazyna Debska-Vielhaber, Susanne Abdulla, Judith Machts, Frank Schreiber, Siegfried Kropf, Peter Körtvelyessy, Sonja Körner, Katja Kollewe, Susanne Petri, Reinhard Dengler, Wolfram S Kunz, Peter J Nestor, Stefan Vielhaber
INTRODUCTION: We aimed to investigate whether sonographic peripheral cross-sectional nerve area (CSA) and progranulin (PGRN), a neuritic growth factor, are related to each other and whether they interact to predict clinical and paraclinical measures in amyotrophic lateral sclerosis (ALS). METHODS: We included 55 ALS patients who had forearm median and ulnar nerve CSA, cerebrospinal fluid (CSF) PGRN and serum PGRN measures available. CSF PGRN was normalized against the CSF/serum albumin ratio (Qalb )...
May 4, 2017: Muscle & Nerve
Christopher R Pierson
No abstract text is available yet for this article.
May 3, 2017: Muscle & Nerve
Maximiliano A Hawkes, Miguel Wilken, Gabriel Vázquez, Mauricio F Farez
INTRODUCTION: The frequency of axonal Guillain-Barré syndrome (GBS) varies among countries. Previous studies supporting the high frequency of axonal GBS in South America have been carried out with pediatric populations. We seek to determine the frequency of axonal GBS in both children and adults in South America. METHODS: This is a retrospective cohort analysis of patients who were diagnosed with GBS between January 2006 and December 2013 in a neurological center in Buenos Aires, Argentina...
May 3, 2017: Muscle & Nerve
Mohammed H Alanazy, Nuha A Alfurayh, Shaza N Almweisheer, Bandar N Aljafen, Taim Muayqil
INTRODUCTION: This study was undertaken to describe a method for quantifying vibration when using a conventional tuning fork (CTF) in comparison to a Rydel-Seiffer tuning fork (RSTF) and to provide reference values. METHODS: Vibration thresholds at index finger and big toe were obtained in 281 subjects. Spearman's correlations were performed. Age, weight and height were analyzed for their covariate effect on vibration threshold. Reference values at the 5(th) percentile were obtained by quantile regression...
May 3, 2017: Muscle & Nerve
Timothy J Eviston, Lauren Sh Chong, Natalie Cg Kwai, Jonathan R Clark, Arun V Krishnan
Introduction - Axonal excitability measures give insight into the biophysical properties of peripheral nerve axons. This study applies these techniques to the study of facial palsy. Methods - 30 patients with established facial palsy due to unresolved Bell's palsy or herpes zoster (>6 months duration), tumour invasion of the facial nerve or traumatic facial nerve injury were assessed using facial nerve excitability techniques. Results - Full recordings were obtained in 23 patients (15 unrecovered Bell's palsy or herpes zoster, 5 trauma, 3 tumour related)...
April 29, 2017: Muscle & Nerve
Sumit Verma, Jenny Lin, Curtis Travers, Courtney McCracken, Durga Shah
INTRODUCTION: This study's objective was to evaluate quantitative EMG (QEMG) using multi-MUP analysis in Duchenne Muscular Dystrophy (DMD). METHODS: Ambulatory DMD boys, ages 5-15 years, were evaluated with QEMG at 6 month intervals over 14 months. EMG was performed in the right biceps brachii (BB) and tibialis anterior (TA) muscles. Normative QEMG data was obtained from age-matched healthy boys. Wilcoxon signed-rank tests were performed. RESULTS: Eighteen DMD subjects were enrolled with a median age of 7 years (interquartile range: 7 - 10)...
April 29, 2017: Muscle & Nerve
Cullen M O'Gorman, Janneke G Weikamp, Michael Baria, Lenie Van den Engel-Hoek, Charles Kassardjian, Nens van Alfen, Andrea J Boon
INTRODUCTION: Cranial muscle fasciculations may be difficult to detect in amyotrophic lateral sclerosis (ALS). Ultrasound (US) detection of fasciculations in these muscles may have clinical utility. METHODS: Patients with suspected ALS were prospectively enrolled. Nerve conduction studies, needle EMG and US examination of cranial muscles were performed. Controls were examined by US only. Fasciculations were counted and scored for each muscle after 10 or 30 seconds...
April 29, 2017: Muscle & Nerve
Clifton L Gooch
No abstract text is available yet for this article.
April 26, 2017: Muscle & Nerve
Chu-Shan Zheng, Xiang Zhang, Yue-Yao Chen, Fang Zhang, Xiao-Hui Duan, Mei-Wei Chen, Lie-Jing Lu, Jun Shen
Introduction:The immune system plays a pivotal role in nerve injury. The aim of this study was to investigate the role of multi-parametric magnetic resonance (MR) imaging in the evaluation of the synergic effect of immunomodulation on nerve regeneration in neurotmesis. METHODS: Rats with sciatic nerve neurotmesis and surgical repair underwent serial multi-parametric MR examinations over an 8 week period after subepineurial microinjection of lipopolysaccharide (LPS) and subsequent subcutaneous injection of FK506 or subepineurial microinjection of LPS or phosphate buffered saline (PBS) alone...
April 26, 2017: Muscle & Nerve
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