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Muscle & Nerve

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https://www.readbyqxmd.com/read/28294390/combined-xil-6r-and-urocortin-2-treatment-restores-mdx-diaphragm-muscle-force
#1
Jennifer Manning, Maria M Buckley, Ken D O'Halloran, Dervla O'Malley
Introduction Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration leading to immobility, respiratory failure and premature death. As chronic inflammation and stress are implicated in DMD pathology, the efficacy of an anti-inflammatory and anti-stress intervention strategy in ameliorating diaphragm dysfunction was investigated. Methods Diaphragm muscle contractile function was compared in wild-type and dystrophin-deficient mdx mice treated with saline, anti-IL-6R antibodies (xIL-6R), the corticotrophin-releasing factor receptor 2 (CRFR2) agonist, urocortin 2 or both xIL-6R and urocortin 2...
March 13, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28295417/subcutaneous-versus-intravenous-immunoglobulin-for-chronic-autoimmune-neuropathies
#2
EDITORIAL
Elie Naddaf, M Hassan Murad, P James B Dyck
No abstract text is available yet for this article.
March 10, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28271533/ultrasound-verification-of-safe-needle-examination-of-the-rhomboid-major-muscle
#3
Daniel Cushman, Michael Henrie, Linda Vernon Scholl, Monica Ludlow, Masaru Teramoto
INTRODUCTION: Palpation of a thoracic rib is a common method for reducing the risk of pneumothorax during electromyographic examination of the rhomboid major muscle, but its accuracy is unknown. METHODS: Two physicians palpated healthy subjects to attempt to identify the center of a rib located beneath the rhomboid major muscle. The identified location was examined with ultrasonography to examine its accuracy and the subject's anatomical depths. RESULTS: Forty-four subjects (88 ribs) were studied...
March 8, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28271524/memoriam-for-william-m-fowler-jr-md-1926-2017
#4
Craig M McDonald, Gregory T Carter
No abstract text is available yet for this article.
March 8, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28271516/can-diffusion-tensor-imaging-and-tractography-represent-cross-sectional-area-of-lumbar-multifidus-in-patients-with-lumbar-spine-disease
#5
Jeehae Oh, Joon-Yong Jung, Young Jin Ko
INTRODUCTION: Cross-sectional area (CSA) is a useful measurement to evaluate the lumbar multifidus, but it cannot reflect morphological characteristics of the entire muscle. Recently, diffusion tensor imaging (DTI) and tractography (DTT) have been used to assess 3-dimensional muscle structures both qualitatively and quantitatively. This study investigated the correlation between CSA and multifidus volume and the clinical utility of DTI and DTT. METHODS: Twenty-eight lumbar multifidi from 14 subjects with lumbar spine disease were analyzed...
March 8, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28271514/translation-and-validation-of-the-mg-qol15-in-dutch
#6
Ellen Strijbos, Fania R Gärtner, Jan J Verschuuren
INTRODUCTION: The 15-item myasthenia gravis quality of life scale (MG-QOL15) is developed to assess the health-related quality of life of patients with myasthenia gravis (MG). The aim of this study was to translate the original English version into Dutch and to test the test-retest reliability and construct validity. METHODS: Fifty patients with MG were included. Test-retest reliability and internal consistency were assessed by the intraclass correlation coefficient (ICC) and Cronbach alpha...
March 8, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28256728/genetic-characterization-of-a-french-cohort-of-gne-mutation-negative-inclusion-body-myopathy-patients-using-exome-sequencing
#7
Mathieu Cerino, Svetlana Gorokhova, Pascal Laforet, Rabah Ben Yaou, Emmanuelle Salort-Campana, Jean Pouget, Shahram Attarian, Bruno Eymard, Jean-François Deleuze, Anne Boland, Anthony Behin, Tanya Stojkovic, Gisele Bonne, Nicolas Levy, Marc Bartoli, Martin Krahn
INTRODUCTION: Hereditary inclusion body myopathy (hIBM) refers to a group of clinically and genetically heterogeneous diseases. The overlapping histochemical features of hIBM with other genetic disorders lead to low diagnostic rates with targeted single-gene sequencing. This is true for the most prevalent form of hIBM, GNEpathy. Thus, we used whole exome sequencing (WES) to evaluate whether a cohort of clinically suspected GNEpathy patients undiagnosed by targeted GNE analysis could be genetically characterized...
March 3, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28249354/placebo-response-in-pain-fatigue-and-performance-possible-implications-for-neuromuscular-disorders
#8
REVIEW
Aziz Shaibani, Elisa Frisaldi, Fabrizio Benedetti
The placebo response in neuromuscular disorders is not well understood. The only available data regarding the underlying mechanisms are related to neuropathic pain. In this review, we describe the factors that contribute to improved outcomes in the placebo arm, with specific attention to pain and fatigue, as well as some of the most important psychobiological mechanisms that may explain such a response. This approach might also improve our insight into the symptomatology and therapeutic responses of other neuromuscular disorders...
March 1, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28249353/ultrasound-is-a-useful-tool-to-evaluate-nerve-involvement-in-children-with-supracondylar-humerus-fractures
#9
Marina A Bellavia, Chiara Cambise, Daniele Coraci, Giulio Maccauro, Antonio Valassina, Luca Padua
No abstract text is available yet for this article.
March 1, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28249351/cross-education-after-high-versus-low-frequency-volume-matched-handgrip-training
#10
Natasha G Boyes, Peter Yee, Joel L Lanovaz, Jonathan P Farthing
INTRODUCTION: Cross-education training programs cause inter-limb asymmetry of strength and hypertrophy. We examined the cross-education effects from a high-frequency (HF) vs. low-frequency (LF) volume-matched handgrip training program on inter-limb asymmetry. METHODS: Right-handed participants completed either HF (n=10; 2 × 6 repetitions 10 times per week) or LF (n=9; 5 × 8 repetitions 3 times per week) training. Testing occurred twice before and once after 4-weeks of right-handed isometric handgrip training totaling 120 weekly repetitions...
March 1, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28245521/interleaved-neuromuscular-electrical-stimulation-after-spinal-cord-injury
#11
Austin J Bergquist, Matheus J Wiest, Yoshino Okuma, David F Collins
INTRODUCTION: Neuromuscular electrical stimulation (NMES) over a muscle belly (mNMES) recruits superficial motor units (MUs) preferentially, while NMES over a nerve trunk (nNMES) recruits MUs evenly throughout the muscle. We tested whether "interleaving" pulses between the mNMES and nNMES sites (iNMES) reduces the fatigability of contractions for people experiencing paralysis due to chronic spinal cord injury. METHODS: Plantarflexion torque and soleus electromyography (M-waves) were recorded from 8 participants...
February 28, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28241376/neurophysiological-recovery-5-years-after-carpal-tunnel-release-in-patients-with-diabetes
#12
Niels O B Thomsen, Gert S Andersson, Jonas Björk, Lars B Dahlin
INTRODUCTION: The long-term results of neurophysiological recovery after carpal tunnel release in patients with diabetes have not been studied. METHODS: Thirty-five patients with diabetes and carpal tunnel syndrome (CTS) were matched with 31 patients without diabetes who had idiopathic CTS, and 27 and 30 patients, respectively participated in this follow-up study. Nerve conduction results at 5 years were compared with previously published results at baseline and 1-year...
February 27, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28239867/inpatient-cost-analysis-for-treatment-of-myasthenia-gravis
#13
Jacklyn O Omorodion, Jesse M Pines, Henry J Kaminski
INTRODUCTION: We explored trends in U.S. inpatient costs of care over a 10-year period. METHODS: We compared myasthenia gravis (MG) to multiple sclerosis (MS) and overall U.S. hospital admissions using the Agency for Healthcare Research and Quality Nationwide Inpatient Sample database for 2003-2013. RESULTS: Total costs of MG inpatient care rose 13-fold from 2003-2013. This was accounted for by a >6-fold increase in discharges and a >2-fold increase in cost per discharge...
February 27, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28224654/a-carpal-tunnel-grading-system-including-combined-sensory-index-diagnosed-mild-cases-relation-to-presenting-features-and-outcomes
#14
Lawrence A Zeidman, Dilip K Pandey
INTRODUCTION: Prior studies have demonstrated superiority of the combined sensory index (CSI) algorithm in diagnosing mild carpal tunnel syndrome (CTS), and have compared presenting symptoms to CTS grade. However, CTS symptoms, signs, and outcomes, including CSI-diagnosed cases, have not been compared to CTS grade. METHODS: We retrospectively studied 294 CTS hands from 2010 to 2013, stratified them into mild, moderate, and severe grades, and analyzed the association between CTS grade and presenting symptoms/signs and outcomes...
February 22, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28224647/electrical-impedance-myography-eim-in-individuals-with-col6-and-lama2-congenital-muscular-dystrophy-a-cross-sectional-and-two-year-analysis
#15
Carmel Nichols, Minal S Jain, Katherine G Meilleur, Tianxia Wu, James Collins, Melissa R Waite, Jahannaz Dastgir, Anam Salman, Sandra Donkervoort, Tina Duong, Katherine Keller, Meganne E Leach, Donovan J Lott, Michelle N McGuire, Leslie Nelson, Anne Rutkowski, Carole Vuillerot, Carsten G Bönnemann, Tanya J Lehky
INTRODUCTION: Electrical impedance myography (EIM) is a non-invasive electrophysiological technique that characterizes muscle properties through bioimpedance. We compared EIM measurements to function, strength, and disease severity in a population with congenital muscular dystrophy (CMD). METHODS: Forty-one patients with CMD, either collagen 6 related disorders (COL6-RD) (n = 21) or laminin alpha 2-related disorders (LAMA2-RD) (n = 20) and 21 healthy pediatric controls underwent 2 yearly EIM exams...
February 22, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28224646/later-stages-of-diabetic-neuropathy-affect-the-complexity-of-the-neuromuscular-system-at-the-knee-during-low-level-isometric-contractions
#16
Eneida Y Suda, Isabel Cn Sacco, Rogerio P Hirata, Afshin Samani, Thiago T Kawamura, Pascal Madeleine
INTRODUCTION: The aim of this study was to evaluate the complexity of force and surface electromyography (sEMG) during knee extension and flexion at low-level isometric contractions in individuals with different degrees of diabetic peripheral neuropathy (DPN). METHODS: Ten control and 38 diabetic subjects performed isometric contractions at 10%, 20% and 30% of maximal voluntary contraction. Knee force and multichannel sEMG from vastus lateralis (VL) and biceps femoris (BF) were acquired...
February 22, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28224640/low-load-resistance-training-with-low-relative-pressure-produces-muscular-changes-similar-to-high-load-resistance-training
#17
Daeyeol Kim, Jeremy P Loenneke, Xin Ye, Debra A Bemben, Travis W Beck, Rebecca D Larson, Michael G Bemben
INTRODUCTION: The purpose of this study was to compare the acute and chronic response of high-load (HL) resistance training to low-load resistance training with a low blood flow restriction (LL-BFR) pressure. METHODS: Participants completed elbow flexion with either HL or LL-BFR, or non-exercise (CON). In the chronic study, participants in the HL and LL-BFR were trained for 8 weeks to determine differences in muscle size and strength. The acute study examined the changes in Pre/Post torque, muscle swelling, and blood lactate...
February 22, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28224639/rigid-spine-syndrome-associated-with-sensory-motor-axonal-neuropathy-resembling-charcot-marie-tooth-disease-is-characteristic-of-bag3-gene-mutations-even-without-cardiac-involvement
#18
Jean-Baptiste Noury, Thierry Maisonobe, Pascale Richard, Valérie Delague, Edoardo Malfatti, Tanya Stojkovic
INTRODUCTION: BAG3 (Bcl-2 associated athanogene-3) mutations have been described in rare cases of rapidly progressive myofibrillar myopathies. Symptoms begin in the first decade with axial involvement and contractures and are associated with cardiac and respiratory impairment in the second decade. Axonal neuropathy has been documented, but usually not as a key clinical feature. METHODS: We report a 24-year-old woman with severe rigid spine syndrome and sensory-motor neuropathy resembling Charcot-Marie-Tooth disease (CMT)...
February 22, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28224635/infections-and-vaccinations-as-possible-triggers-of-inflammatory-myopathies
#19
Vidya Limaye, Caroline Smith, Barbara Koszyca, Peter Blumbergs, Sophia Otto
INTRODUCTION: The role of vaccinations and infections in triggering idiopathic inflammatory myopathies (IIM) has not been confirmed. METHODS: Among patients with histologically-confirmed myositis, infections or vaccinations administered prior to myositis onset were determined. The characteristics of this group were compared with controls (myositis patients without prior infection or vaccination). RESULTS: The frequency of IIM with a prior vaccination was 20 of 206, (9...
February 22, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28224633/gluteal-compartment-syndrome-with-neurologic-impairment-report-of-two-cases-and-review-of-the-literature
#20
Greg D Kuhlman, Kelly G Gwathmey
INTRODUCTION: We describe two patients who developed gluteal compartment syndrome (GCS) in the context of drug overdose. One patient developed a sciatic neuropathy and one patient a lumbosacral plexopathy. METHODS: We reviewed the literature of atraumatic GCS and resultant neurological impairment. RESULTS: We review 26 cases (our two and 24 previously published) of GCS and neurological impairment. All patients developed GCS in the context of drug or alcohol overdose...
February 22, 2017: Muscle & Nerve
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