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Muscle & Nerve

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https://www.readbyqxmd.com/read/29144551/the-impact-of-volumetric-muscle-loss-injury-on-persistent-motoneuron-axotomy
#1
Benjamin T Corona, Kate E Flanagan, Christian M Brininger, Stephen M Goldman, Jarrod A Call, Sarah M Greising
INTRODUCTION: Volumetric muscle loss (VML) occurs following significant traumatic injury or surgical removal of skeletal muscle, resulting in non-recoverable loss of tissue and long-term dysfunction. Perhaps less recognized is that VML injuries inherently disrupt the neuromuscular unit, resulting in fiber denervation and presumptive motor unit rearrangement, expansion, and/or loss. To characterize neural dysfunction we quantified motoneuron axotomy, in efforts to understand how this relates to the temporal coordination of neuromuscular and morphological alterations due to injury...
November 16, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29136279/letter-ultrasound-in-the-evaluation-of-neuromuscular-complications-of-radiation-therapy
#2
LETTER
Mario Cacciavillani, Alessandro Salvalaggio, Marta Ruiz, Chiara Briani
No abstract text is available yet for this article.
November 14, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29130528/relationship-between-extensibility-and-collagen-expression-in-immobilized-rat-skeletal-muscle
#3
Yuichiro Honda, Miho Tanaka, Natsumi Tanaka, Ryo Sasabe, Kyo Goto, Hideki Kataoka, Junya Sakamoto, Jiro Nakano, Minoru Okita
INTRODUCTION: This study investigated longitudinal changes in muscle extension and collagen expression in an immobilized rat soleus muscle, and assessed the relationship between both elements. METHODS: Soleus muscles of the control and immobilization groups (1, 2, 4, 8, and 12 weeks) were used for analysis of muscle extensibility and collagen expression. RESULTS: The slope value/physiological cross sectional area (PCSA; a parameter for muscle extensibility) and hydroxyproline (a parameter for collagen expression) were significantly higher in the immobilization group than in the control group for all experimental time points...
November 11, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29130507/neurofascin-155-igg4-neuropathy-pathophysiological-insights-spectrum-of-clinical-severity-and-response-to-treatment
#4
Nidhi Garg, Susanna B Park, Con Yiannikas, Steve Vucic, James Howells, Yu-Ichi Noto, Emily K Mathey, John D Pollard, Matthew C Kiernan
INTRODUCTION: Sensorimotor neuropathy associated with IgG4 antibodies to neurofascin-155 (NF155) was recently described. The clinical phenotype is typically associated with young onset, distal weakness and in some cases, tremor. METHODS: From a consecutive cohort of 55 patients diagnosed with chronic inflammatory demyelinating polyneuropathy, screening for anti-NF155 antibodies was undertaken. Patients underwent clinical assessment, diagnostic neurophysiology, including peripheral axonal excitability studies and nerve ultrasound...
November 11, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29130505/muscle-membrane-properties-in-a-pig-sepsis-model-effect-of-norepinephrine
#5
Delphine Boërio, Thiago D Corrêa, Stephan M Jakob, Karin A Ackermann, Hugh Bostock, Werner J Z'Graggen
INTRODUCTION: Sepsis-induced myopathy and critical illness myopathy are common causes of muscle weakness in intensive care patients. This study investigated the effect of different mean arterial blood pressure (MAP) levels on muscle membrane properties following experimental sepsis. METHODS: Sepsis was induced with faecal peritonitis in 12 out of 18 anesthetized and mechanically ventilated pigs. Seven were treated with a high (75-85 mm Hg) and 5 with a low (≥60 mm Hg) MAP target for resuscitation...
November 11, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29130502/cardiac-involvement-in-the-muscular-dystrophies
#6
REVIEW
Nicholas J Silvestri, Haisam Ismail, Peter Zimetbaum, Elizabeth M Raynor
Cardiac disease is a common clinical manifestation present in a variety of neuromuscular disorders, most notably the muscular dystrophies. Heart disease may produce the presenting or predominant symptoms in these disorders but more often does not result in clinical features at the time of initial presentation. Cardiac involvement in the muscular dystrophies results from pathologic changes in the myocardium and the cardiac conduction system, leading to cardiomyopathy and/or rhythm disturbances including supraventricular arrhythmias, life-threatening ventricular arrhythmias, and sudden cardiac death...
November 11, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29130498/peripheral-nerve-ultrasound-in-friedreich-s-ataxia
#7
Eoin Mulroy, Luciana Pelosi, Ruth Leadbetter, Purwa Joshi, Miriam Rodrigues, Stuart Mossman, Dean Kilfoyle, Richard Roxburgh
Introduction Sensory impairment in Friedreich's ataxia (FRDA) is generally accepted as being due to a ganglionopathy. The degree of contribution from axonal pathology remains a matter of debate. Nerve ultrasound may be able to differentiate these processes. Methods The ultrasound cross-sectional area of median, ulnar, tibial and sural nerves of 8 patients with FRDA was compared with 8 age- and gender-matched healthy controls and with reference values in our population. Results The nerves of the patients with FRDA were significantly larger than healthy controls' at all upper limb sites (p< 0...
November 11, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29125635/a-review-of-the-diagnosis-and-treatment-of-periodic-paralysis
#8
REVIEW
Jeffrey M Statland, Bertrand Fontaine, Michael G Hanna, Nicholas Johnson, John T Kissel, Valeria A Sansone, Perry B Shieh, Rabi N Tawil, Jaya Trivedi, Stephen C Cannon, Robert C Griggs
Periodic paralyses (PP) are rare neuromuscular disorders caused by mutations in skeletal muscle sodium, calcium, and potassium channel genes. PP include hypokalemic paralysis, hyperkalemic paralysis, and Andersen-Tawil Syndrome. Common features of PP include autosomal dominant inheritance, onset typically in the first or second decades, episodic attacks of flaccid weakness, which are often triggered by diet or rest after exercise. Diagnosis is based on the characteristic clinic presentation then confirmed by genetic testing...
November 10, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29105161/non-motor-manifestations-in-als-patients-with-tracheostomy-and-invasive-ventilation
#9
Yuki Nakayama, Toshio Shimizu, Chiharu Matsuda, Michiko Haraguchi, Kentaro Hayashi, Yoko Mochizuki, Masahiro Nagao, Akihiro Kawata, Eiji Isozaki
INTRODUCTION: This study aimed to investigate non-motor manifestations in amyotrophic lateral sclerosis (ALS) patients with tracheostomy and invasive ventilation (TIV) and their relevance to disease progression. METHODS: Sixty-seven ALS patients with TIV were enrolled, and followed-up prospectively. The patients were classified at the final evaluation into two subgroups according to the duration of TIV use or disease stage measured by communication impairment. We identified non-motor manifestations and investigated their frequencies and differences across the stages...
November 3, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29105153/making-sense-of-antisense-oligonucleotides-a-narrative-review
#10
REVIEW
Neelam Goyal, Pushpa Narayanaswami
Synthetic nucleic acid sequences that bind to ribonucleic acid (RNA) through Watson-Crick base pairing are known as antisense oligonucleotides (ASOs) because they are complementary to "sense strand" nucleic acids. ASOs bind to selected sequences of RNA and regulate the expression of genes by several mechanisms depending on their chemical properties and targets. They can be used to restore deficient protein expression, reduce the expression of a toxic protein, modify functional effects of proteins or reduce toxicity of mutant proteins...
November 3, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29105117/severe-mononeuritis-multiplex-after-rituximab-in-igm-%C3%AE%C2%BA-monoclonal-gammopathy
#11
Alexis A Lizarraga, Karlo J Lizarraga, James E Hoffman, Dana P Ascherman, Robert T Shebert, Ashok Verma
No abstract text is available yet for this article.
November 3, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29105112/dynamin-2-associated-myopathy-with-electrical-but-not-clinical-myotonia
#12
Amro M Stino, Stanley J Iyadurai
No abstract text is available yet for this article.
November 3, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29105105/low-back-pain-due-to-superior-cluneal-nerve-entrapment-clinicopathological-study
#13
Kyongsong Kim, Jun Shimizu, Toyohiko Isu, Kiyoharu Inoue, Yasuhiro Chiba, Naotaka Iwamoto, Daijiro Morimoto, Masanori Isobe, Akio Morita
INTRODUCTION: We studied the clinical and nerve pathological features in 6 patients whose low back pain (LBP) was relieved by superior cluneal nerve (SCN) neurectomy to determine whether nerve compression was the mechanism underlying this type of LBP. METHODS: ALL 6 patients (7 nerves) underwent SCN neurectomy for intractable LBP. Their clinical outcomes and the pathological features of 7 nerves were reviewed. RESULTS: All patients reported LBP relief immediately after SCN neurectomy...
November 3, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053902/sonographic-evaluation-of-the-vagus-nerves-protocol-reference-values-and-side-to-side-differences
#14
Johann Otto Pelz, Elena Belau, Philipp Henn, Niels Hammer, Joseph Classen, David Weise
INTRODUCTION: Reported sonographic reference values for the vagus nerves (VNs) vary greatly. We aimed to generate reference values in a large cohort and examine intrarater, interrater, and across-ultrasound systems agreement. METHODS: The VNs of 60 healthy subjects were examined by 2 sonographers and with 2 ultrasound systems. Cross-sectional areas (CSAs) of each VN were assessed at the level of the carotid sinus [proximal measurement level (ML)] and thyroid gland (distal ML)...
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053898/chronic-pain-has-a-strong-impact-on-quality-of-life-in-facioscapulohumeral-muscular-dystrophy
#15
Germán Morís, Libby Wood, Roberto FernáNdez-Torrón, José Andrés González Coraspe, Chris Turner, David Hilton-Jones, Fiona Norwood, Tracey Willis, Matt Parton, Mark Rogers, Simon Hammans, Mark Roberts, Elizabeth Househam, Maggie Williams, Hanns Lochmüller, Teresinha Evangelista
INTRODUCTION: Earlier small case series and clinical observations reported on chronic pain playing an important role in facioscapulohumeral dystrophy (FSHD). The aim of this study was to determine the characteristics and impact of pain on quality of life (QoL) in patients with FSHD. METHODS: We analyzed patient reported outcome measures collected through the U.K. FSHD Patient Registry. RESULTS: Of 398 patients, 88.6% reported pain at the time of study...
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053894/french-translation-and-cross-cultural-adaptation-of-the-myotonic-dystrophy-health-index-mdhi
#16
Cynthia Gagnon, Marjolaine Tremblay, Isabelle Côté, Chad Heatwole
INTRODUCTION: Validation studies of disease-specific instruments for myotonic dystrophy type-1 (DM1) are required prior to their global use in clinical trials involving different cultures and countries. Here we translate and culturally adapt the Myotonic Dystrophy Health Index (MDHI), a disease-specific patient reported outcome measure, for a French DM1 population. METHOD: Using the ISPOR Task Force method for translation and adaptation of patient-reported outcome questionnaires, we created a French translation of the MDHI...
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053893/unilateral-faciobrachial-weakness-an-unusual-neuromuscular-presentation-of-west-nile-virus-infection
#17
Ahmed M El-Dokla, Rashedul Hasan, Sara T Ali
No abstract text is available yet for this article.
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053890/prospective-comparison-of-acute-motor-axonal-neuropathy-and-acute-inflammatory-demyelinating-polyradiculoneuropathy-in-140-children-with-guillain-barr%C3%A3-syndrome-in-india
#18
Jayantee Kalita, Mritunjai Kumar, Usha K Misra
INTRODUCTION: There have been few reports on subtypes of Guillain-Barré syndrome (GBS) in children. We compared clinical and laboratory findings of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). METHODS: One hundred forty children with GBS were included. Based on nerve conduction study (NCS) findings, patients were subclassified as AIDP, AMAN, acute motor sensory axonal neuropathy (AMSAN), and equivocal...
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053882/electrodiagnostic-studies-in-the-intensive-care-unit-a-comparison-study-two-decades-later
#19
Ajitesh Ojha, Sasha A Zivkovic, David Lacomis
INTRODUCTION: Since the late 1980s, critical illness myopathy (CIM) and polyneuropathy (CIP) have been increasingly recognized in the intensive care unit (ICU). We explored whether these causes of ICU weakness were now more likely to lead to electrodiagnostic studies (EDX) at our institution than they were 19-20 years earlier. METHODS: We reviewed 100 consecutive ICU patients who underwent EDX from 2009-2015 and compared them to a previously reported study population from 1990-1995...
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053881/hiv-antiretrovirals-and-peripheral-neuropathy-a-moving-target
#20
EDITORIAL
Michelle Kaku, David M Simpson
No abstract text is available yet for this article.
October 20, 2017: Muscle & Nerve
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