Read by QxMD icon Read

Artificial Organs

Tomohiro Mizuno, Koso Egi, Kenji Sakai, Keiji Oi, Tsuyoshi Hachimaru, Tohru Makita, Kiyotoshi Oishi, Hirokuni Arai
Off-pump coronary artery bypass grafting (OPCAB) in patients with acute myocardial infarction (AMI) is difficult because of circulatory deterioration during displacement of the heart. At our institution, we performed minimally circulatory-assisted on-pump beating coronary artery bypass grafting (MICAB) in these patients. During MICAB, support flow was controlled at a minimal level to maintain a systemic blood pressure of approximately 100 mm Hg and a pulmonary arterial systolic pressure of <30 mm Hg, providing optimal pulsatile circulation for end-organ perfusion and prevention of heart congestion...
October 26, 2016: Artificial Organs
Shigeyuki Okahara, Zu Soh, Satoshi Miyamoto, Hidenobu Takahashi, Hideshi Itoh, Shinya Takahashi, Taijiro Sueda, Toshio Tsuji
During cardiopulmonary bypass (CPB), blood viscosity conspicuously increases and decreases due to changes in hematocrit and blood temperature. Nevertheless, blood viscosity is typically not evaluated, because there is no technology that can provide simple, continuous, noncontact monitoring. We modeled the pressure-flow characteristics of an oxygenator in a previous study, and in that study we quantified the influence of viscosity on oxygenator function. The pressure-flow monitoring information in the oxygenator is derived from our model and enables the estimation of viscosity...
October 26, 2016: Artificial Organs
Yaron Hellman, Adnan S Malik, Kathleen A Lane, Changyu Shen, I-Wen Wang, Thomas C Wozniak, Zubair A Hashmi, Sarah D Munson, Jeanette Pickrell, Marco A Caccamo, Irmina Gradus-Pizlo, Azam Hadi
Currently, blood pressure (BP) measurement is obtained noninvasively in patients with continuous flow left ventricular assist device (LVAD) by placing a Doppler probe over the brachial or radial artery with inflation and deflation of a manual BP cuff. We hypothesized that replacing the Doppler probe with a finger-based pulse oximeter can yield BP measurements similar to the Doppler derived mean arterial pressure (MAP). We conducted a prospective study consisting of patients with contemporary continuous flow LVADs...
October 26, 2016: Artificial Organs
Shannon B Spencer, Shigang Wang, Karl Woitas, Kristen Glass, Allen R Kunselman, Akif Ündar
The objective of this study was to evaluate an alternative neonatal extracorporeal life support (ECLS) circuit with a RotaFlow centrifugal pump and Better-Bladder (BB) for hemodynamic performance and gaseous microemboli (GME) capture in a simulated neonatal ECLS system. The circuit consisted of a Maquet RotaFlow centrifugal pump, a Quadrox-iD Pediatric diffusion membrane oxygenator, 8 Fr arterial cannula, and 10 Fr venous cannula. A "Y" connector was inserted into the venous line to allow for comparison between BB and no BB...
October 13, 2016: Artificial Organs
Yi Liu, Monica Faria, Edward Leonard
In most extracorporeal filtration devices such as hemodialysis a peristaltic pump is used to circulate blood. Pump function requires the repeated compression of an elastomeric tube from which particles may be shed into the circulatory system, a process called spallation. Earlier studies are likely to have missed the large number of small particles (<2 µm in diameter) that appear. The present study uses more modern equipment that detects and sizes particles down to 0.6 µm. As polyvinyl chloride (PVC) tubing is commonly used for this process, a series of studies was conducted on three different types to study its spallation characteristics, along with a co-extruded PVC/polyurethane tubing known for its enhanced biocompatibility properties...
October 13, 2016: Artificial Organs
Richard Cheng, Danny Ramzy, Babak Azarbal, Francisco A Arabia, Fardad Esmailian, Lawrence S Czer, Jon A Kobashigawa, Jaime D Moriguchi
For Interagency Registry for Mechanically Assisted Circulatory Support profiles 1 and 2 cardiogenic shock patients initially placed on extracorporeal membrane oxygenation (ECMO), whether crossover to more durable devices is associated with increased survival, and its optimal timing, are not established. Profiles 1 and 2 patients placed on mechanical support were prospectively registered. Survival and successful hospital discharge were compared between patients placed on ECMO only, ECMO with early crossover, and ECMO with delayed crossover...
September 23, 2016: Artificial Organs
Gabriel Fuchs, Niclas Berg, Anders Eriksson, Lisa Prahl Wittberg
As of today, there exist no reliable, objective methods for early detection of thrombi in the extracorporeal membrane oxygenators (ECMO) system. Within the ECMO system, thrombi are not always fixed to a certain component or location in the circuit. Thus, clot fragments of different shapes and consistencies may circulate and give rise to vibrations and sound generation. By bedside sound measurements and additional laboratory experiments (although not detailed herein), we found that the presence of particles (clots or aggregates and fragments of clots) can be detected by analyzing the strength of infra-sound (< 20 Hz) modes of the spectrum near the inlet and outlet of the centrifugal pump in the ECMO circuit...
September 22, 2016: Artificial Organs
Jamshid H Karimov, David J Horvath, Nicole Byram, Gengo Sunagawa, Patrick Grady, Martin Sinkewich, Nader Moazami, Shiva Sale, Leonard A R Golding, Kiyotaka Fukamachi
The unique device architecture of the Cleveland Clinic continuous-flow total artificial heart (CFTAH) requires dedicated and specific air-removal techniques during device implantation in vivo. These procedures comprise special surgical techniques and intraoperative manipulations, as well as engineering design changes and optimizations to the device itself. The current study evaluated the optimal air-removal techniques during the Cleveland Clinic double-ended centrifugal CFTAH in vivo implants (n = 17)...
September 22, 2016: Artificial Organs
Kean Guan Kuan, Mau Nam Wee, Wen Yuan Chung, Rohan Kumar, Soeren Torge Mees, Ashley Dennison, Guy Maddern, Markus Trochsler
Normothermic machine perfusion has enormous potential to improve organ preservation and expand the organ donor pool. It is well established in other organs but not the pancreas, which has especially strict organ acceptance criteria. We established a model of normothermic hemoperfusion of the porcine pancreas with and without addition of the kidney as a dialysis organ. Four pancreases were harvested and perfused for 120 min with autologous whole blood at body temperature, two with parallel perfusion of the kidney and two without...
September 22, 2016: Artificial Organs
Oluseyi A Adejumo, Adaobi U Solarin, Moses T Abiodun, Ayodeji A Akinbodewa
One of the major challenges of kidney transplantation is shortage of kidney donors. Care givers (CGs) are potential kidney donors, but the majority of them are unwilling to donate due to inadequate knowledge on kidney donation. This study evaluated the knowledge of kidney donation and its determinants among CGs in two tertiary hospitals in Southwest Nigeria. This was a cross-sectional study that was carried out in the Kidney Care Centre (KCC), Ondo and Babcock University Teaching Hospital (BUTH), Ilishan-Remo using a self-administered pretested questionnaire that assessed knowledge of kidney donation and its determinants...
September 22, 2016: Artificial Organs
Akira T Kawaguchi, Jean Philippe Collet, Philippe Cluzel, Ralouka Makri, Mojgan Laali, Catherine DeFrance, Hiroyuki Furuya, Akira Murakami, Pascal Leprince
Although transcatheter aortic valve implantation (TAVI) has been indicated for patients with high surgical risk, indications for or against the procedure become more difficult as vascular access becomes more proximal and/or invasive in order to accommodate patients with even higher risks. We compared preoperative factors including the European System for Cardiac Operative Risk Evaluation (EuroSCORE) and Society of Thoracic Surgeons Predicted Risk of Mortality (STS) score with postoperative survival in 195 patients undergoing TAVI during 2...
September 22, 2016: Artificial Organs
Chung Hee Baek, Hyosang Kim, Won Seok Yang, Duck Jong Han, Su-Kil Park
The outcomes of transplantation have improved, but more than 50% of kidney transplantation (KT) recipients are still reported to have renal function of chronic kidney disease (CKD) stage 3 at 1 year after KT. We reviewed all 1235 patients who received a KT in our institution between 2008 and 2012. Among these recipients, 77 and 289 cases were included in the estimated glomerular filtration rate (eGFR) at 1 year after KT 30-44 (CKD stage 3b) group and eGFR 45-59 (CKD stage 3a) group, respectively. Longer duration of dialysis (odds ratio [OR] = 1...
September 22, 2016: Artificial Organs
Mina Farag, Nikhil Prakash Patil, Anton Sabashnikov, Rawa Arif, Gábor Szabó, Klaus Kallenbach, Arjang Ruhparwar, Matthias Karck, Thorsten Brenner, Stefan Hofer, Alexander Weymann
Cardiopulmonary bypass (CPB) is a known mediator of systemic inflammatory response. Extracorporeal circulations are undergoing continuous modifications and optimizations to achieve better results. Hence we aim to compare the inflammatory response associated with two recent miniature extracorporeal circulation systems during normothermic CPB. We measured plasma levels of cytokines including interleukin (IL)-1β, IL-6, IL-10, tumor necrosis factor-α, migration inhibitory factor (MIF), receptor for advanced glycation endproduct, and cluster of differentiation 40 ligand in 60 consecutive patients during the first 24 h after CPB...
September 22, 2016: Artificial Organs
Choon Hwai Yap, Chang Quan Lai, Ivan Guang Hui Loh, Thaddaeus Zhongren Ong
Roller pumps are widely used in many medical procedures including cardiopulmonary bypass, left/right ventricular assist, and hemodialysis. However, to date, the problem of the roller pumping mechanism causing significant hemolysis remains unresolved. It has been shown that with under-occlusion of the roller pump, hemolysis can be reduced, but significant reduction of the mean flow rate also takes place due to backflow through the under-occlusion. We performed an investigation of the flow dynamics of an under-occluded roller pump which featured significantly higher amount of under-occlusion than previously investigated...
September 22, 2016: Artificial Organs
Jungmin Yoon, Kyoung Won Nam, Jun Chang Lee, Dong Pyo Jang, In Young Kim
For hearing-impaired individuals with neurological motor deficits or finger/arm amputation due to accident or disease, hearing aid adjustment using a conventional finger manipulation-based remote controller is unavailable, and a more dedicated, hands-free alternative is required. In this study, we propose an eye-blinking-based beamforming control scheme for hearing aid users. Three electroencephalogram signals measured around the ears were utilized to detect eye-blinking patterns based on a three-layer artificial neural network...
September 21, 2016: Artificial Organs
Stephanie Schmitz, Kristin Unthan, Marc Sedlaczek, Felix Wald, Thomas Finocchiaro, Sotirios Spiliopoulos, Reiner Koerfer, Ulrich Steinseifer
At our institute a total artificial heart is being developed. It is directly actuated by a linear drive in between two ventricles, which comprise membranes to separate the drive and blood flow. A compliance chamber (CC) is needed to reduce pressure peaks in the ventricles and to increase the pump capacity. Therefore, the movement of the membrane is supported by applying a negative pressure to the air volume inside the drive unit. This study presents the development of the implantable CC which is connected to the drive unit of the total artificial hearts (TAH)...
September 1, 2016: Artificial Organs
Tsung-Yu Tsai, Feng-Chun Tsai, Pei-Chun Fan, Chih-Hsiang Chang, Chan-Yu Lin, Wei-Wen Chang, Shen-Yang Lee, Hsiang-Hao Hsu, Ya-Chung Tian, Ji-Tseng Fang, Chih-Wei Yang, Yung-Chang Chen
Patients on extracorporeal membrane oxygenation (ECMO) usually have high mortality rate and poor outcome. Age, Creatinine, and Left Ventricular Ejection Fraction (ACEF) score is an easy-calculating score and provides good performance on mortality prediction in patients undergoing cardiac operations or percutaneous coronary intervention, but it has not been applied to patients on ECMO before. In this study, we aimed to use ACEF score obtained within 1 week of ECMO support for in-hospital mortality prediction in patients on ECMO due to severe myocardial failure...
September 1, 2016: Artificial Organs
Pedram Hanafizadeh, Nima Mirkhani, Mohammad Reza Davoudi, Mahtab Masouminia, Keyvan Sadeghy
Coronary arteries, which are branched from the sinuses, have tangible effects on the hemodynamic performance of the bileaflet mechanical heart valve (BMHV), especially in the diastolic phase. To better understand this issue, a computer model of ascending aorta including realistic sinus shapes and coronary arteries has been generated in this study in order to investigate the BMHV performance during diastole. Three-dimensional transient numerical analysis is conducted to simulate the diastolic blood flow through the hinges and in coronary arteries under the assumption of non-Newtonian behavior...
October 2016: Artificial Organs
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Artificial Organs
Zhijin Li, Fangfang Xu, Zhifa Wang, Taiqiang Dai, Chao Ma, Bin Liu, Yanpu Liu
Macrophages are involved in the full processes of tissue healing or regeneration and play an important role in the regeneration of a variety of tissues. Although recent evidence suggests the role of different macrophage phenotypes in adipose tissue expansion, metabolism, and remodeling, the spectrum of macrophage phenotype in the adipose tissue engineering field remains unknown. The present study established a rat model of adipose tissue regeneration using a tissue engineering chamber. Macrophage phenotypes were assessed during the regenerative process in the model...
October 2016: Artificial Organs
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"