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Artificial Organs

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https://www.readbyqxmd.com/read/30417399/long-term-survival-for-hemodialysis-patients-differ-in-japan-versus-europe-and-the-usa-what-might-the-reasons-be
#1
EDITORIAL
Kenichi Matsuda, Rachel Fissell, Stephen Ash, Bernd Stegmayr
No abstract text is available yet for this article.
November 11, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30412274/bilateral-mini-thoracotomy-approach-for-minimally-invasive-implantation-of-heartmate-3
#2
Massimiliano Carrozzini, Jonida Bejko, Gino Gerosa, Tomaso Bottio
Left ventricular assist devices (LVADs) are an established option for the treatment of end-stage heart failure. Last generation devices are characterized by a miniaturized pump size, allowing for intra-pericardial placement. This feature enabled the introduction of less-invasive implantation techniques, which have been linked to many favourable effects. The HeartMate 3 LVAD is a continuous-flow centrifugal pump, recently introduced for clinical use. Here we describe the minimally invasive implantation of the HeartMate 3 through a bilateral mini-thoracotomy...
November 9, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30412273/silk-enhances-ligamentization-of-polyethylene-terephthalate-artificial-ligament-in-a-canine-anterior-cruciate-ligament-reconstruction-model
#3
Yunlong Zhi, Jia Jiang, Peng Zhang, Shiyi Chen
Anterior cruciate ligament (ACL) reconstruction is the leading treatment for ACL rupture. LARS (Ligament Advanced Reinforcement System) ligament, which is made of polyethylene terephthalate (PET), is the most frequently used artificial ligament for ACL reconstruction. However, PET is hydrophobic, so it is difficult to induce the ingrowth of autologous tissue. The aim of this study is to explore the effects of silk hybrid on the ligamentization of PET artificial ligament in a canine ACL reconstruction model...
November 9, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30412266/variations-in-sagittal-and-coronal-stem-tilt-and-their-impact-on-prosthetic-impingement-in-total-hip-arthroplasty
#4
Takeyuki Tanaka, Masaki Takao, Takashi Sakai, Hidetoshi Hamada, Sakae Tanaka, Nobuhiko Sugano
Optimization of the combined anteversion of cup and stem has been emphasized to avoid prosthetic impingement in total hip arthroplasty. However, no study has focused on the impact of variations in sagittal and coronal stem tilt against the whole femur on prosthetic range of motion. The purposes of the present study were to quantify the anatomical variation of sagittal and coronal tilt of the proximal canal axis against the femoral retrocondylar coordinate system, that is variation of sagittal and coronal stem tilt and 2) to determine their impact on the zone of impingement-free cup position using computer simulation...
November 9, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30411818/conventional-or-minimized-cardiopulmonary-bypass-support-during-coronary-artery-bypass-grafting-an-analysis-by-means-of-perfusion-and-body-mass-index
#5
Zdenek Provaznik, Christoph Unterbuchner, Alois Philipp, Maik Foltan, Marcus Creutzenberg, Simon Schopka, Daniele Camboni, Christof Schmid, Bernhard Floerchinger
The use of minimized cardiopulmonary bypass support to reduce the side effects of extracorporeal circulation is still contradictorily discussed. This study compares perfusion operated by conventional (CCPB) and minimized (MCPB) cardiopulmonary bypass support during coronary artery bypass grafting (CABG). METHODS: This study includes the data of 5164 patients treated at our department between 2004 and 2014. Tissue perfusion during cardiopulmonary bypass support and cardiac arrest was assessed by means of body mass index, hemodilution, blood pressure with corresponding pump flow and venous oxygen saturation, serum lactate, and serum pH...
November 9, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30411808/a-time-to-heal-the-emprove-protocol
#6
EDITORIAL
April A Grant, Edward B Lineen, Michael Koerner, Rodrigo Vianna, Matthias Loebe, Ali Ghodsizad
No abstract text is available yet for this article.
November 9, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30402887/va-ecmo-support-in-nonsurgical-patients-with-refractory-cardiogenic-shock-pre-implant-outcome-predictors
#7
Thomas Fux, Manne Holm, Matthias Corbascio, Lars H Lund, Jan van der Linden
Refractory cardiogenic shock (RCS) is associated with a high mortality. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used as acute cardiopulmonary support but selection of VA-ECMO candidates remains challenging. There are limited data on which pre-VA-ECMO variables that predict outcome. The aim of this study was to identify pre-VA-ECMO predictors of 90-day mortality. We retrospectively analyzed 76 consecutive patients (median age 52; interquartile range [IQR]: 37-60) supported with VA-ECMO due to RCS...
November 6, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30398290/is-the-new-infant-jarvik-2015-suitable-for-patients-8-kg-in-vitro-study-using-a-hybrid-simulator
#8
Arianna Di Molfetta, Krzysztof Zielinski, Gianfranco Ferrari, Macej Kozarski, Piotr Okrzeja, Roberta Iacobelli, Sergio Filippelli, Gianluigi Perri, Marek Darowski, Massimo Massetti, Robert Jarvik, Antonio Amodeo
Our aim was to study the feasibility of implanting the Infant Jarvik 2015 in patients weighing less than 8 kg. The Infant Jarvik 2015 left ventricular assist device (LVAD) was tested in a hybrid simulator of the cardiovascular system reproducing specific patients' hemodynamics for different patient weights (2-7 kg). For each weight, the sensitivity of the pump to different circulatory parameters (peripheral resistance, left ventricular elastance, right ventricular elastance, heart rate, and heart filling characteristics) has been tested repeating for each experiment a pump ramp (10 000-18 000 rpm)...
November 6, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30393925/in-vitro-examination-of-the-ventriflo-true-pulse-pump-for-failing-fontan-support
#9
Phillip M Trusty, Mike Tree, Doug Vincent, Jeffrey P Naber, Kevin Maher, Ajit P Yoganathan, Shriprasad R Deshpande
The current methodology of Fontan palliation results in a one "pump" circulatory system with passive flow to the lungs. Inherent hemodynamic differences exist between a biventricular circulatory system and this modified physiology, leading to a host of long-term complications. Mechanical circulatory support (MCS) is a potential option to combat these pathophysiological conditions. In this study, we examine the VentriFlo True Pulse Pump as a MCS option to support a failing Fontan patient. An in vitro circulatory loop was used to model a failing Fontan patient, reproducing pathophysiological pressures and flow rates...
November 4, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30393885/is-it-possible-to-implant-heartmate-3-less-invasively-new-pump-new-approach
#10
Sinan Sabit Kocabeyoglu, Umit Kervan, Dogan Emre Sert, Ertekin Utku Unal, Burcu Demirkan, Yesim Guray, Emre Aygun, Osman Fehmi Beyazal, Mehmet Karahan, Mustafa Pac
HeartMate 3 (HM3) left ventricular assist device (LVAD) is a compact, intrapericardial, centrifugal flow pump with a fully magnetically levitated rotor and a wide range of operation (2-10 L/min) to accommodate a broad range of clinical needs. We analyzed our experience with Heartware VAD (HVAD) and HM3 implantation through minimally invasive left thoracotomy (MILT) and upper minimal J sternotomy. Between March 2015 and October 2016, 31 patients who underwent LVAD implantation through MILT were included in this study...
November 4, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30393881/use-of-a-mechanical-circulatory-support-simulation-to-study-pump-interactions-with-the-variable-hemodynamic-environment
#11
David J Horvath, Dennis W Horvath, Jamshid H Karimov, Nicole Byram, Barry D Kuban, Takuma Miyamoto, Kiyotaka Fukamachi
The Virtual Mock Loop, a versatile virtual mock circulation loop, was developed using a lumped-parameter model of the mechanically assisted human circulatory system. Inputs allow specification of a variety of continuous-flow pumps (left, right, or biventricular assist devices) and a total artificial heart that can self-regulate between left and right pump outputs. Hemodynamic inputs were simplified using a disease-based input panel, allowing selection of a combination of cardiovascular disease states, including systolic and diastolic heart failure, stenosis, and/or regurgitation in each of the four valves, and high to low systemic and pulmonary vascular resistance values...
November 4, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30375680/pegylated-carboxyhemoglobin-bovine-sanguinate-%C3%A2-ameliorates-myocardial-infarction-in-a-rat-model
#12
Akira T Kawaguchi, Amankeldi Salybekov, Mariko Yamano, Hiroaki Kitagishi, Kaori Sekine, Tetsuro Tamaki
Artificial oxygen (O2 ) carriers were reported to be protective in ischemia/reperfusion (I/R) in various organs including the heart. In the current study, 20 rats underwent ligation (MI) of the left anterior descending artery, were treated with 10 mL/kg of PEGylated carboxyhemoglobin bovine (SANGUINATE® , S+, n=10) or saline (S-, n=10) 10 min after MI and daily thereafter for three days, and were followed by weekly echocardiography for four weeks, when they had left ventricular pressure volume relationship (PVR) analyses followed by necropsy...
October 30, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30375673/increasing-the-removal-of-protein-bound-uremic-toxins-by-liposome-supported-hemodialysis
#13
Yuanyuan Shi, Yifeng Wang, Shuai Ma, Tingyan Liu, Huajun Tian, Qiuyu Zhu, Wenji Wang, Yulin Li, Feng Ding
Protein-bound uremic toxins (PBUTs) accumulate at high plasma levels and cause various deleterious effects in end-stage renal disease patients because their removal by conventional hemodialysis is severely limited by their low free-fraction levels in plasma. Here, we assessed the extent to which solute removal can be increased by adding liposomes to the dialysate. The uptake of liposomes by direct incubation in vitro showed an obvious dose-response relationship for p-cresyl sulfate (PCS) and indoxyl sulfate (IS) but not for hippuric acid (HA)...
October 30, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30375662/computational-analysis-of-customized-cruciate-retaining-total-knee-arthroplasty-restoration-of-native-knee-joint-biomechanics
#14
Yong-Gon Koh, Jin-Ah Lee, Pill Ku Chung, Kyoung-Tak Kang
The purpose of this study was to verify if customized prosthesis better preserves the native knee joint kinematics and provides lower contact stress on the polyethylene (PE) insert owing to the wider bone preservation than that of standard off-the-shelf prosthesis in posterior cruciate-retaining type total knee arthroplasty (TKA). Validated finite element (FE) models for were developed to evaluate the knee joint kinematics and contact stress on the PE insert after TKA with customized and standard off-the-shelf (OTS) prostheses as well as in normal healthy knee through FE analysis under dynamic loading conditions...
October 30, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30375659/beat-to-beat-detection-of-aortic-valve-opening-in-heartware-left-ventricular-assist-device-patients
#15
Rachel Clifford, Desiree Robson, Christoph Gross, Francesco Moscato, Heinrich Schima, Paul Jansz, Peter S Macdonald, Christopher S Hayward
BACKGROUND: cfLVADs result in a significant reduction in aortic valve (AV) opening, which have been associated with several complications. Reliable monitoring of AV opening is needed to determine whether pump speed adjustment may be able to minimize adverse outcomes. METHODS: AV status was recorded continuously by echocardiography for 4 minutes in 3 states in 18 HeartWare HVAD patients: 2 minutes at rest, and 1 minute each following Valsalva maneuver and supine leg-raising...
October 30, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30374991/effects-of-pulsatile-control-algorithms-for-diagonal-pump-on-hemodynamic-performance-and-hemolysis
#16
Shigang Wang, Madison Force, Morgan K Moroi, Sunil Patel, Allen R Kunselman, Akif Ündar
The objective of this study is to compare hemodynamic performances under different pulsatile control algorithms between Medos DeltaStream DP3 and i-cor diagonal pumps in simulated pediatric and adult ECLS systems. An additional pilot study was designed to test hemolysis using two pumps during 12h-ECLS. The experimental circuit consisted of parallel combined pediatric and adult ECLS circuits using an i-cor pump head and either an i-cor console or Medos DeltaStream MDC console, a Medos Hilite 2400 LT oxygenator for the pediatric ECLS circuit, and a Medos Hilite 7000 LT oxygenator for the adult ECLS circuit...
October 29, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30374981/stress-and-exposure-time-on-von-willebrand-factor-degradation
#17
Choon-Sik Jhun, Christopher Siedlecki, Lichong Xu, Branka Lukic, Raymond Newswanger, Eric Yeager, John Reibson, Joshua Cysyk, William Weiss, Gerson Rosenberg
Despite the prevailing use of the continuous flow left ventricular assist devices (cf-LVAD), acquired von Willebrand syndrome (AvWS) associated with cf-LVAD still remains a major complication. As AvWS is known to be dependent on shear stress (τ) and exposure time (texp ), this study examined the degradation of high molecular weight multimers (HMWM) of von Willebrand factor (vWF) in terms of τ and texp . Two custom apparatus, i.e., capillary-tubing-type degrader (CTD) and Taylor-Couette-type degrader (TCD) were developed for short-term (0...
October 29, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30374978/sizable-scaffold-free-tissue-engineered-articular-cartilage-construct-for-cartilage-defect-repair
#18
In-Su Park, Ri Long Jin, Hyun Ju Oh, Minh-Dung Truong, Byung Hyune Choi, Sang-Hyug Park, Do Young Park, Byoung-Hyun Min
This study introduces an implantable scaffold-free cartilage tissue construct (SF) that is composed of chondrocytes and their self-produced extracellular matrix (ECM). Chondrocytes were grown in vitro for up to 5 weeks and subjected to various assays at different time points (1, 7, 21, and 35 days). For in vivo implantation, full-thickness defects (n = 5) were manually created on the trochlear groove of the both knees of rabbits (16-week old) and 3 week-cultured SF construct was implanted as an allograft for a month...
October 29, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30370640/acquired-von-willebrand-syndrome-and-blood-pump-design
#19
REVIEW
Gerson Rosenberg, Christopher A Siedlecki, Choon-Sik Jhun, William J Weiss, Keefe Manning, Steven Deutsch, William Pierce
The existence of acquired von Willebrand syndrome (AVWS) in patients with continuous flow left ventricular assist devices (LVADs) is well documented and has been verified by numerous investigators. AVWS has not been observed to occur in pulsatile devices such as the SynCardia total artificial heart (TAH), the HeartMate XVE, and the Thoratec pulsatile ventricular assist device (PVAD) used as a single pump. AVWS can also occur in patients with aortic stenosis, ventricular septal defect, mitral stenosis, and patent ductus arteriosus...
October 28, 2018: Artificial Organs
https://www.readbyqxmd.com/read/30357882/durable-left-ventricular-assist-device-implantation-in-extremely-obese-heart-failure-patients
#20
Andy Y Lee, Kristen M Tecson, Brian Lima, Asad F Shaikh, Justin Collier, Sasha Still, Ronald Baxter, J Michael DiMaio, Joost Felius, Sandra A Carey, Gonzalo V Gonzalez-Stawinski, Richard Nauret, Marcus Wong, Shelley A Hall, Susan M Joseph
BACKGROUND: Left ventricular assist devices (LVADs) have improved clinical outcomes and quality of life for those with end-stage heart failure. However, the costs and risks associated with these devices necessitate appropriate patient selection. LVAD candidates are becoming increasingly more obese and there are conflicting reports regarding obesity's effect on outcomes. Hence, we sought to evaluate the impact of extreme obesity on clinical outcomes after LVAD placement. METHODS: Consecutive LVAD implantation patients at our center from June 2008- May 2016 were studied retrospectively...
October 25, 2018: Artificial Organs
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