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International Journal of Artificial Organs

Hugo Lo Pinto, Jérôme Allyn, Romain Persichini, Bruno Bouchet, Gilbert Brochier, Olivier Martinet, Caroline Brulliard, Dorothée Valance, Benjamin Delmas, Eric Braunberger, Laurence Dangers, Nicolas Allou
PURPOSE: Few data are available on the potential benefits and risks of red blood cell transfusion in patients undergoing extracorporeal membrane oxygenation. The aim of this study was to identify the determinants and prognosis of red blood cell transfusion in patients undergoing extracorporeal membrane oxygenation, with a special focus on biological parameters during extracorporeal membrane oxygenation treatment. METHODS: We conducted a single-center retrospective cohort study including all consecutive patients who underwent extracorporeal membrane oxygenation between January 2010 and December 2015...
July 1, 2018: International Journal of Artificial Organs
Caglar Ozturk, I Basar Aka, Ismail Lazoglu
AIMS: Impeller design has a significant impact on the overall performance of a blood pump. In this study, the effect of the blade curvature was investigated by performing in silico and in vitro studies on a recently developed centrifugal blood pump. METHODS: A computational fluid dynamics study was performed for the flow rates of 3-5 L/min at 2000 r/min. The computational fluid dynamics model was also applied on the US Food and Drug Administration (FDA) benchmark blood pump to validate our computational method...
July 1, 2018: International Journal of Artificial Organs
Yoshitsugu Nakamura, Sam Emmanuel, Fumiaki Shikata, Chihiro Shirai, Yujiro Ito, Miho Kuroda
OBJECTIVE: To investigate whether radial artery pressure is a reliable surrogate measure of central arterial pressure as approximated by femoral artery pressure in minimally invasive cardiac surgery with retrograde perfusion via femoral cannulation. METHOD: Fifty-two consecutive patients undergoing minimally invasive cardiac surgery were prospectively included in this study. Cardiopulmonary bypass was established via a femoral artery cannulation and femoral vein...
July 1, 2018: International Journal of Artificial Organs
Michela Bozzetto, Paolo Brambilla, Stefano Rota, Bogdan Ene-Iordache, Sandro Sironi, Giuseppe Remuzzi, Andrea Remuzzi
INTRODUCTION: Autogenous arteriovenous fistula is the preferred vascular access for hemodialysis, but it has high rates of non-maturation and early failure due to vascular stenosis. Convincing evidence supports a key role of local hemodynamics in vascular remodeling, suggesting that unsteady and disturbed flow conditions may be related to stenosis formation in arteriovenous fistula. The purpose of our study was to explore the feasibility of coupling contrast-free magnetic resonance imaging and computational fluid dynamics in longitudinal studies to identify the role of local hemodynamic changes over time in inducing vessel wall remodeling in arteriovenous fistula...
July 1, 2018: International Journal of Artificial Organs
Lucía Gullón, Judit Gutiérrez-Gutiérrez, Robert T Sánchez Del Arco, Andrés Rivera, Ignacio Fernández, Juan F Del Cañizo
INTRODUCTION: Liver perfusion machines are close to becoming a reality in the transplantation field. However, depending on the techniques used and the goals pursued, their application is limited in the research field. Here, we present the entire development of a perfusion system with self-made engineering, completely autonomous controls, and a high degree of versatility that allows the design of different studies on liver functionality. METHODS: A user-friendly interface permits real-time monitoring and remote control by the devices within the circuit...
July 1, 2018: International Journal of Artificial Organs
Fedaa Al Halabi, Oleksandr Gryshkov, Antonia I Kuhn, Viktoria M Kapralova, Birgit Glasmacher
Polyvinylidene fluoride and its co-polymer with trifluoroethylene are promising biomaterials for supporting nerve regeneration processes because of their proven biocompatibility and piezoelectric properties that could stimulate cell ingrowth due to electrical activity upon mechanical deformation. This study reports the piezoelectric effect of electrospun polyvinylidene fluoride scaffolds in response to mechanical loading. An impact test machine was used to evaluate the generation of electrical voltage upon application of an impact load...
July 1, 2018: International Journal of Artificial Organs
Miwako Oatari, Miyuki Uehara, Fumiaki Shimizu
PURPOSE: The purpose of this study was to assess the utility of a polyglycolic acid-collagen tube and to investigate its possible application in the field of facial nerve reconstruction. METHODS: Wistar rats were used in this study. In the operation, a periauricular incision was made to expose the buccal and marginal branches of the facial nerve. Gaps of 10 mm were created by resection of a part of the nerve into the marginal branches and the buccal branch of the left facial nerve...
July 1, 2018: International Journal of Artificial Organs
Li Deng, Hui Yang, Weixin Meng, Yue Chen, Guang Hu, Hongyu Liu
PURPOSE: During extracorporeal circulation in heart surgery, blood is exposed to non-physiological conditions, such as high shear stress, foreign surfaces, turbulence, and hypothermia. These factors cause damage to the red blood cells, which is manifested by immediate and delayed hemolysis or some changes in the mechanical properties of red blood cells, defined as sublethal trauma. Unfortunately, sublethal trauma is hard to detect, and there is not enough morphological evidence regarding red blood cell sublethal trauma...
July 1, 2018: International Journal of Artificial Organs
Achim Koch, Nikolaus Pizanis, Carolin Olbertz, Omar Abou-Issa, Christian Taube, Alexis Slama, Clemens Aigner, Heinz G Jakob, Markus Kamler
OBJECTIVE: To enlarge the donor pool for lung transplantation, an increasing number of extended criteria donor lungs are used. However, in more than 50% of multi-organ donors the lungs are not used. Ex vivo lung perfusion offers a unique possibility to evaluate and eventually recondition the injured donor lungs. The aim of our study was to assess the enlargement of the donor pool and the outcome with extended criteria donor lungs after ex vivo lung perfusion. PATIENTS AND METHODS: Data were prospectively collected in our lung transplant database...
July 1, 2018: International Journal of Artificial Organs
Geetha Bhat, Gardner L Yost, Kamel Ibrahim, Patroklos Pappas, Antone Tatooles
INTRODUCTION: Inflammatory processes are well-characterized risk factors in cardiovascular disease including advanced heart failure. Previous studies have utilized individual white cell subtypes in risk analysis, and a recent study has focused on the efficacy of the neutrophil-to-lymphocyte ratio in evaluating negative outcomes following left ventricular assist device implantation. To investigate the interaction between the left ventricular assist device and white cell counts, we assessed longitudinal changes in neutrophil-to-lymphocyte ratio following left ventricular assist device implantation...
June 1, 2018: International Journal of Artificial Organs
Tuncay Sahutoglu, Elif Sahutoglu
BACKGROUND/AIMS: Severe metabolic acidosis during cardiopulmonary resuscitation is an important and yet unresolved issue. The potential use of hemodialysis for severe metabolic acidosis during cardiopulmonary resuscitation was investigated. METHODS: Acute hemodialyses between January 2012 and April 2017 were reviewed for patients with concomitant hemodialysis and cardiopulmonary resuscitation. In addition, MEDLINE was searched for similar reports. Data were extracted from hospital records...
June 1, 2018: International Journal of Artificial Organs
Benjamin Torner, Lucas Konnigk, Sebastian Hallier, Jitendra Kumar, Matthias Witte, Frank-Hendrik Wurm
PURPOSE: Numerical flow analysis (computational fluid dynamics) in combination with the prediction of blood damage is an important procedure to investigate the hemocompatibility of a blood pump, since blood trauma due to shear stresses remains a problem in these devices. Today, the numerical damage prediction is conducted using unsteady Reynolds-averaged Navier-Stokes simulations. Investigations with large eddy simulations are rarely being performed for blood pumps. Hence, the aim of the study is to examine the viscous shear stresses of a large eddy simulation in a blood pump and compare the results with an unsteady Reynolds-averaged Navier-Stokes simulation...
June 1, 2018: International Journal of Artificial Organs
Sabina Pw Guenther, Yasuhiro Shudo, William Hiesinger, Dipanjan Banerjee
OBJECTIVES: In intractable cardiogenic shock, extracorporeal life support frequently is the last treatment option. Outcomes of prolonged veno-arterial extracorporeal life support for cardiac failure are poorly defined. METHODS: We retrospectively analyzed 10 patients (4 females, age = 36 ± 16 years) who underwent prolonged extracorporeal life support (≥7 days) from December 2015 to March 2017 for cardiogenic shock. The primary endpoint was survival to hospital discharge...
June 1, 2018: International Journal of Artificial Organs
Rethinam Senthil, Robert Berly, Thimmiah Bhargavi Ram, Nallathambi Gobi
PURPOSE: In this study, a blend of synthetic polymer (poly(vinyl) alcohol), natural polymer (collagen type I from fish bone), and graphene oxide nanoparticles is used to fabricate a composite nanofibrous scaffold, by electrospinning, for their potential application in accelerated wound healing. METHODS: The scaffold was characterized for its physicochemical and mechanical properties. In vitro studies were carried out using human keratinocyte cell line (HaCaT) which proved the biocompatibility of the scaffold...
May 1, 2018: International Journal of Artificial Organs
Ayesha Idrees, Valeria Chiono, Gianluca Ciardelli, Siegfried Shah, Richard Viebahn, Xiang Zhang, Jochen Salber
Three-dimensional cell culture systems are urgently needed for cytocompatibility testing of biomaterials. This work aimed at the development of three-dimensional in vitro dermal skin models and their optimization for cytocompatibility evaluation. Initially "murine in vitro dermal construct" based on L929 cells was generated, leading to the development of "human in vitro dermal construct" consisting of normal human dermal fibroblasts in rat tail tendon collagen type I. To assess the viability of the cells, different assays CellTiter-Blue® , RealTime-Glo™ MT, and CellTiter-Glo® (Promega) were evaluated to optimize the best-suited assay to the respective cell type and three-dimensional system...
May 1, 2018: International Journal of Artificial Organs
Günes Dogan, Jasmin Hanke, Jakob Puntigam, Axel Haverich, Jan D Schmitto
PURPOSE: Giant-cell myocarditis represents a rare and often fatal autoimmune disorder. Despite extracorporeal life support being a valid treatment option, alternatives to control the underlying inflammatory response remain sparse. A new hemoadsorption device (CytoSorb) has recently been introduced to treat patients with an excessive inflammatory response. METHODS: A 57-year-old patient developed fulminant right heart failure, respiratory insufficiency, hemodynamic instability, and oliguric-anuric renal failure...
May 1, 2018: International Journal of Artificial Organs
Tarek M Saleh, Ebtehal A Ahmed, Lina Yu, Ho-Hyun Kwak, Kamal H Hussein, Kyung-Mee Park, Byung-Jae Kang, Ki-Young Choi, Kyung-Sun Kang, Heung-Myong Woo
Decellularization of tissues can significantly improve regenerative medicine and tissue engineering by producing natural, less immunogenic, three-dimensional, acellular matrices with high biological activity for transplantation. Decellularized matrices retain specific critical components of native tissues such as stem cell niche, various growth factors, and the ability to regenerate in vivo. However, recellularization and functionalization of these matrices remain limited, highlighting the need to improve the characteristics of decellularized matrices...
May 1, 2018: International Journal of Artificial Organs
Philipp Berg, Sylvia Saalfeld, Gábor Janiga, Olivier Brina, Nicole M Cancelliere, Paolo Machi, Vitor M Pereira
Endovascular treatment of intracranial aneurysms using flow-diverting devices has revolutionized the treatment of large and complex lesions due to its minimally invasive nature and potential clinical outcomes. However, incomplete or delayed occlusion and persistent intracranial aneurysm growth are still an issue for up to one-third of the patients. We evaluated two patients with intracranial aneurysm located at the internal carotid artery who were treated with flow-diverting devices and had opposite outcomes...
May 1, 2018: International Journal of Artificial Organs
Sara R Knigge, Birgit Glasmacher
A lot of research has been done in the field of magnesium-based implant material. This study is focused on finding an explanation for the large disparity in results from similar experiments in literature. The hypothesis is that many different measurement protocols are used to quantify magnesium degradation and this leads to inconsistent results. Cylindrical, pure magnesium samples were used for this study. The degradation took place in revised simulated body fluid at 37°C. Hydrogen evolution was measured to quantify the degradation...
May 1, 2018: International Journal of Artificial Organs
Yoshiyuki Takami, Naoki Hoshino, Yasuchika Kato, Yusuke Sakurai, Kentaro Amano, Yoshiro Higuchi, Masato Tochii, Michiko Ishida, Hiroshi Ishikawa, Yasushi Takagi, Yukio Ozaki
INTRODUCTION: Ventricular assist device is used in the patients with severe heart failure due to cardiotoxicity of anthracyclines, which are widely used chemotherapeutic agents for a wide range of malignant tumors. However, recovery of cardiac function is rare. METHODS: We present the clinical course of a 43-year-old woman in remission from diffuse large B-cell lymphoma after the chemotherapy including anthracyclines, who presented in cardiogenic shock 8 months after the end of chemotherapy...
July 2018: International Journal of Artificial Organs
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