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International Journal of Artificial Organs

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https://www.readbyqxmd.com/read/29148023/fluid-structure-interaction-model-analysis-of-cerebrospinal-fluid-circulation-in-patients-with-continuous-flow-left-ventricular-assist-devices
#1
Jessica G Y Luc, Clifford A Pierre, Kevin Phan, Yashar S Vahedein, Alexander S Liberson, William K Cornwell, Steven J Phillips, Vakhtang Tchantchaleishvili
PURPOSE: The current 1-dimensional fluid structure interaction model (FSI) for understanding cerebrospinal fluid (CSF) circulation requires pulsatility as a precondition and has not been applied to patients with continuous-flow left ventricular assist devices (CF-LVAD) where pulsatility is chronically reduced. Our study aims to characterize the behavior of CSF pressure and flow in patients with CF-LVADs using a computational FSI model. METHODS: Utilizing the computational FSI model, CSF production in choroid plexuses of the 4 ventricles was specified as a boundary condition for the model...
November 16, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29148021/routine-adoption-of-timp2-and-igfbp7-biomarkers-in-cardiac-surgery-for-early-identification-of-acute-kidney-injury
#2
Chiara Levante, Fiorenza Ferrari, Chiara Manenti, Faeq Husain-Syed, Marta Scarpa, Tommaso Hinna Danesi, Massimo De Cal, Valentina Corradi, Grazia M Virzì, Alessandra Brendolan, Federico Nalesso, Pércia Bezerra, Salvador Lopez-Giacoman, Sara Samoni, Mara Senzolo, Davide Giavarina, Loris Salvador, Raffaele Bonato, Silvia De Rosa, Enrico Rettore, Claudio Ronco
BACKGROUND AND PURPOSE: Acute Kidney Injury (AKI) is a severe complication affecting many hospitalized patients after cardiac surgery, with negative impacts on short- and long-term clinical outcomes and on healthcare costs. Recently, clinical interest has been aimed at defining and classifying AKI, identifying risk factors and developing diagnostic strategies to identify patients at risk early on. Achieving an early and accurate diagnosis of AKI is a crucial issue, because prevention and timely detection may help to prevent negative clinical outcomes and avoid AKI-associated costs...
November 16, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29148026/the-influence-of-hemodialysis-membrane-permeability-on-serum-procalcitonin-values-in-patients-on-maintenance-hemodialysis
#3
Taoufiq Aatif, Yassir Zajjari, Anas Jeaidi
BACKGROUND: Procalcitonin (PCT) has emerged as a marker of infection and it could be useful for detection of systemic bacterial infections in patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD). The aim of this study was to assess the influence of HD membrane permeability to PCT serum levels in noninfected HD patients on maintenance HD. METHODS: In a prospective comparative study, we measured PCT serum levels and C reactive protein (CRP) before and after HD in 36 sessions (18 sessions of HD with low-flux = Group L; and 18 sessions with high flux membranes = Group H), in 18 chronic HD patients without history of infection...
November 9, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29148020/effect-of-different-types-of-disinfection-solution-and-aging-on-the-hardness-and-colour-stability-of-maxillofacial-silicone-elastomers
#4
Pinar Cevik, Arzu Z Yildirim-Bicer
INTRODUCTION: Understanding the effect of aging and different disinfecting agents on the physical properties of pigmented maxillofacial silicones may help eliminate the current uncertainty as to the best follow-up suggestions for the patients treated with silicone prostheses. METHODS: One hundred fifty specimens (14 × 2 mm) were evaluated for colour and 75 specimens (30 × 10 mm) for hardness (total, 225 specimens). Five specimens were used for hardness testing in each disinfecting solution while 10 silicone specimens were used for colour evaluation...
November 9, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29148024/blue-planet-dialysis-novel-water-sparing-strategies-for-reducing-dialysate-flow
#5
Alejandra Molano-Triviño, Benjamin Wancjer, Mauro M Neri, Akash N Karopadi, Mitchell Rosner, Claudio Ronco
INTRODUCTION: Hemodialysis (HD) is an expensive therapy in economic and in ecological terms, owing to a high carbon footprint and significant consumption of natural sources, especially water. Our aim was to review strategies to diminish waste of water in maintenance dialysis, exploring previously described water reuse trends and less known strategies for reducing the dialysate flow. METHODS: We conducted a systematic review of water-sparing strategies, including the reuse of reverse osmosis rejected water and the reduction of dialysate flux...
November 8, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29148022/hemodialysis-versus-peritoneal-dialysis-an-observational-study-in-two-international-centers
#6
Renhua Lu, Carla Estremadoyro, Xiaohuan Chen, Mingli Zhu, Leonardo C Ribeiro, Yucheng Yan, Alessandra Brendolan, Wei Fang, Carlo Crepaldi, Zhaohui Ni, Leyi Gu, Claudio Ronco
INTRODUCTION: Given that it is difficult to randomize end-stage renal disease (ESRD) patients to either hemodialysis (HD) or peritoneal dialysis (PD), differences between these renal replacement therapy (RRT) modalities are of major interest and remain controversial. METHODS: All data on maintenance dialysis patients during 2009 to 2013 in the Renji Hospital in Shanghai, China and in the San Bortolo Hospital in Vicenza, Italy were selected. Patients who changed their therapy from HD to PD or PD to HD during this study were excluded...
November 8, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29148025/a-3-day-diary-of-dietary-protein-and-calorie-intake-by-serum-phosphate-concentration-and-binder-use-in-hemodialysis-patients
#7
Meiry J S Araújo, Luciana F Silva, Maria T S Martins, Cacia M Matos, Marcelo B Lopes, Rilma F S Santos, LarissaS Santos, Angiolina C Kraychete, Márcia T S Martins, Fernanda A Silva, Antonio A Lopes
INTRODUCTION: The use of phosphate binders to control hyperphosphatemia may allow diets less restricted in protein and calories for maintenance hemodialysis (MHD) patients. The study compared intakes of protein, calorie and phosphate among MHD patients with different serum phosphate concentrations, taking into account binder use. The hypothesis was that low serum phosphate would be associated with low intakes of protein and calories only in patients not on binders. METHODS: A cross-sectional study of 443 patients enrolled in the Prospective Study of the Prognosis of Chronic Hemodialysis Patients (PROHEMO) in Salvador, Brazil, with stratified sampling on serum phosphate: ≤3...
November 4, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29099541/pulmonary-arteriovenous-extracorporeal-membrane-oxygenation-to-avoid-pulmonary-overflow-during-total-artificial-heart-implantation
#8
Vakhtang Tchantchaleishvili, Jessica G Y Luc, Fabio Sagebin, Joshua K Wong, Howard T Massey
Total artificial hearts (TAH) can be used as a bridge to transplant or, occasionally, as destination therapy for patients with severe biventricular dysfunction. Not infrequently TAHs are placed in patients with severe low flow states, in which the lungs of these patients are unable to adjust rapidly to the "normal" right ventricular output of a TAH. These patients may develop variable degrees of pulmonary edema secondary to stress failure of the pulmonary capillaries requiring increased respiratory support, which can occasionally be fatal...
November 2, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29099540/depression-and-anxiety-in-patients-undergoing-left-ventricular-assist-device-implantation
#9
Scott Lundgren, Cecilia Y M Poon, Ahmed Selim, Brian D Lowes, Ronald Zolty, Adam Burdorf, Yael Potashnik-Peled, Michael J Moulton, John Y Um, Eugenia Raichlin
BACKGROUND: Depression and anxiety are associated with a worse prognosis in heart failure patients. The aim of this study was to identify the prevalence of depression and anxiety in left ventricular assist device (LVAD) candidates and assess their effect on post-LVAD outcomes. METHODS: Based on the pre-LVAD psychological assessment, the total cohort of 246 patients were divided into 4 groups: 1) no depression or anxiety (NDep&Anx group, n = 138); 2) isolated depression (Dep group, n = 42); 3) isolated anxiety (Anx group, n = 32), and 4) combined depression and anxiety (Dep&Anx group, n = 34)...
November 1, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29048702/time-kill-assays-of-amphotericin-b-plus-anidulafungin-against-candida-tropicalis-biofilms-formed-on-two-different-biomaterials
#10
Marcelo E Fernández-Rivero, José L Del Pozo, Paula Ramírez, Eulogio Valentín, Alba Ruiz-Gaitán, Javier Pemán, Emilia Cantón
PURPOSE: To determine the fungicidal activity by time-killing assays of amphotericin B (AMB) combined with anidulafungin (ANF) against biofilms of 2 clinical isolates of Candida tropicalis and the reference strain ATCC® 750, developed on polytetrafluoroethylene (PTFE) and titanium, using the CDC Biofilm Reactor (CBR) as an in vitro model. METHODS: Biofilms were developed for 24 hours on the disk surfaces and then exposed to AMB (40 mg/L), ANF (8 mg/L), alone and combined...
October 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29048703/a-pilot-study-on-the-efficacy-and-safety-of-a-minimally-invasive-surgical-and-anesthetic-approach-for-ventricular-assist-device-implantation
#11
Jonida Bejko, Demetrio Pittarello, Gianclaudio Falasco, Guido Di Gregorio, Vincenzo Tarzia, Giulio Rizzoli, Dario Gregori, Gino Gerosa, Tomaso Bottio
BACKGROUND: The aim of our study was to compare 2 surgical and anesthetic approaches during ventricular assist device implantation. METHODS: 68 patients (50.4 ± 17.1 years old) were supported with the HeartWare® HVAD (32 patients) and the Jarvik 2000 VAD (36 patients) between January 2010 and August 2016. Two surgical techniques were applied: a minimally invasive approach with the aid of paravertebral-block (mini-invasive group, 41 patients) and a standard-surgical-approach with the aid of general anesthesia (27 patients)...
October 16, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29027193/single-center-experience-with-intraoperative-extracorporeal-membrane-oxygenation-use-in-lung-transplantation
#12
Tugba Cosgun, Sandra Tomaszek, Isabelle Opitz, Markus Wilhelm, Macé M Schuurmans, Walter Weder, Ilhan Inci
BACKGROUND: Studies have shown that survival after lung transplantation is impaired if extracorporeal membrane oxygenation (ECMO) support is implemented. We investigated the outcome and potential independent risk factors on survival in recipients undergoing lung transplantation with intraoperative ECMO support. MATERIALS AND METHODS: Medical records of recipients were retrospectively evaluated (January 2000-December 2014). Retransplantation and bridge to transplantation on ECMO were excluded...
October 9, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28967087/analysis-of-mandibular-changes-using-panoramic-based-indices-in-patients-with-chronic-renal-failure
#13
Cansu K Secgin, Cemal K Kulah, Ayşe Gulsahi
INTRODUCTION: Chronic renal failure (CRF) is a progressive disease affecting many systems and causing dental and periodontal problems, in particular a decrease or loss in the amount of cortical bone that is visible on radiographs. Panoramic radiography is useful for determining these changes. The aim of this study was to evaluate cortical parts of the mandible using panoramic-based indices in patients with CRF. METHODS: 70 subjects with CRF were included in the study...
September 29, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28983901/a-novel-insight-into-the-role-of-entry-tears-in-type-b-aortic-dissection-pressure-measurements-in-an-in-vitro-model
#14
Stefania Marconi, Ettore Lanzarone, Hector De Beaufort, Michele Conti, Santi Trimarchi, Ferdinando Auricchio
INTRODUCTION: Predicting aortic growth in acute type B dissection is fundamental in planning interventions. Several factors are considered to be growth predictors in the literature and, among them, size and location of entry tears have been recognized to particularly influence the false lumen pressure. In this study, we develop an in vitro setting to analyze the actual impact of size and location of the entry tears on false lumen pressure, in the absence of other confounding factors such as the deformability of the aortic wall...
September 28, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28967085/tracheal-decellularization-using-a-combination-of-chemical-physical-and-bioreactor-methods
#15
Yourka D Tchoukalova, Justin M Hintze, Richard E Hayden, David G Lott
INTRODUCTION: The purpose of this study was to compare different decellularization protocols with the conventional detergent enzymatic method (DEM) using continuous agitation. METHODS: The first experiment compared conventional DEM with sonication and lyophilization+freeze-thaw cycles. A second experiment was carried out to compare time-adjusted DEM (2-hour instead of 4-hour incubations with 4% deoxycholate) to decellularization in a bioreactor. Cellularity was determined by DNA-quantitation, H&E-staining and immunostaining for major histocompatibility complex-1 (MHC-1)...
September 28, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28967084/the-effect-of-ultrasonically-activated-irrigation-and-laser-based-root-canal-irrigation-methods-on-debris-removal
#16
Aysenur Kamaci, Berdan Aydin, Necdet Erdilek
PURPOSE: To test the efficacy of debris removal of 5 in vitro irrigation protocols: conventional irrigation, irrigation activated by ultrasound, Er:YAG laser with photon-induced photoacoustic streaming (PIPS) tip, and 2 diode laser techniques. METHODS: The root canals of 75 extracted human canine teeth were enlarged and bisected longitudinally. Standardized grooves were prepared 2-6 mm from the root apex and filled with 0.5 mm of dentine debris. The teeth were reassembled and irrigated using 1 of the following techniques (n = 15/technique): (1) conventional irrigation, (2) diode laser irrigation - tip placed 2 mm from working length, (3) diode laser irrigation - tip placed at root canal orifice, (4) Er:YAG laser - PIPS, and (5) ultrasonically activated irrigation...
September 22, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28967086/intestinal-mucosal-barrier-dysfunction-in-sap-patients-with-mods-ameliorated-by-continuous-blood-purification
#17
Qing Shen, Zhengrong Li, Shanshan Huang, Liman Li, Hua Gan, Xiao-Gang Du
BACKGROUND: Dysfunction of the intestinal mucosal barrier plays an important role in the pathophysiology of severe acute pancreatitis (SAP). Continuous blood purification (CBP) has been shown to improve the prognosis of SAP patients. In order to investigate the effect of CBP on intestinal mucosal barrier dysfunction in SAP patients with MODS, we conducted in vivo and in vitro experiments to explore the underlying mechanisms. METHODS: The markers for the assessment of intestinal mucosal barrier function including serum diamine oxidase (DAO), endotoxin and intestinal epithelial monolayer permeability were detected during CBP therapy...
September 14, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28885664/postoperative-acute-kidney-injury-in-living-donor-liver-transplantation-recipients
#18
Hakan K Atalan, Bulent Gucyetmez, Serdar Aslan, Serafettin Yazar, Kamil Y Polat
PURPOSE: There are many risk factors for postoperative acute kidney injury in liver transplantation. The aim of this study is to investigate the risk factors for postoperative acute kidney injury in living donor liver transplantation recipients. METHODS: 220 living donor liver transplantation recipients were retrospectively evaluated in the study. According to the Kidney Disease Improving Global Outcomes Guidelines, acute kidney injury in postoperative day 7 was investigated for all patients...
September 5, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28885663/removal-of-bile-acids-by-extracorporeal-therapies-an-in-vitro-study
#19
Jens Hartmann, Stephan Harm
INTRODUCTION: Bile acids (BAs) accumulating in the circulation in patients with liver failure are considered to be responsible for pruritus, which strongly impairs quality of life of the affected patients. The aim of this study was the in vitro characterization of different BAs regarding their removability with high-flux dialysis as well as with different adsorbents, and the evaluation of their binding to plasma proteins. METHODS: Dialysis experiments were conducted in pediatric circuits with human plasma...
September 5, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28885662/differential-diagnosis-of-alterations-in-arterial-flow-and-tissue-oxygenation-on-venoarterial-extracorporeal-membrane-oxygenation
#20
Anna Hofer, Sylvia Leitner, Michaela Kreuzer, Jens Meier
BACKGROUND: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) may be life-saving in several clinical situations, but it is also one of the most invasive therapeutic procedures, with significant potential for life-threatening complications. Pulse pressure waves are typically very small or even absent at the onset of ECMO therapy, and will reappear with the improvement of cardiac function. A low pulse pressure may indicate low cardiac output due to heart failure during sustained ECMO support...
September 5, 2017: International Journal of Artificial Organs
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