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International Journal of Artificial Organs

Edward Jozef Baert, Jelle Vandersteene, Frank Dewaele, Anna Vantilborgh, Dirk Van Roost, Filip De Somer
INTRODUCTION: A dynamic model to evaluate thrombus formation on intravascular catheters in vitro is presented. The model enables fluid infusion, variation in the catheter orientation, and variable flow conditions. It was applied on a catheter used to shunt cerebrospinal fluid to a vein, a dural venous sinus, for the treatment of hydrocephalus. METHODS: Fresh human blood-filled circuits were circulated in a non-occlusive roller pump. A catheter infused either with cerebrospinal fluid, Ringer's lactate, or no fluid (control) was inserted through each circuit's wall...
November 4, 2018: International Journal of Artificial Organs
Yusu Ni, Yi Jiang, Kaishi Wang, Zhengzhong Shao, Xin Chen, Shan Sun, Huiqian Yu, Wen Li
OBJECTIVE: To characterize the morphology of chondrocytes and the expression and secretion of active collagen II by these cells cultured within a regenerated silk fibroin film. Silk fibroin film cytocompatibility and the effect of silk fibroin on chondrocytes in vitro were also evaluated. METHODS: Chondrocytes were transfected with a lentivirus containing a green fluorescent protein marker and cultured within a regenerated silk fibroin film. Effects on chondrocyte adhesion, growth, and expression of functional collagen II were assessed in vitro by analysis with immunofluorescent histochemistry and laser scanning confocal microscopy...
October 30, 2018: International Journal of Artificial Organs
Matteo Selmi, Wei-Che Chiu, Venkat Keshav Chivukula, Giulio Melisurgo, Jennifer Ann Beckman, Claudius Mahr, Alberto Aliseda, Emiliano Votta, Alberto Redaelli, Marvin J Slepian, Danny Bluestein, Federico Pappalardo, Filippo Consolo
INTRODUCTION: Despite significant technical advancements in the design and manufacture of Left Ventricular Assist Devices, post-implant thrombotic and thromboembolic complications continue to affect long-term outcomes. Previous efforts, aimed at optimizing pump design as a means of reducing supraphysiologic shear stresses generated within the pump and associated prothrombotic shear-mediated platelet injury, have only partially altered the device hemocompatibility. METHODS: We examined hemodynamic mechanisms that synergize with hypershear within the pump to contribute to the thrombogenic potential of the overall Left Ventricular Assist Device system...
October 24, 2018: International Journal of Artificial Organs
Michael Achim Lommel, Leonid Goubergrits, Klaus Affeld, Ulrich Kertzscher
INTRODUCTION: Continuous-flow left ventricular assist devices have evolved from short-time therapy into permanent or so-called destination therapy. One complication in long-term usage is bleeding, which is presumably attributed to shear-induced interference of left ventricular assist devices with the coagulation system. METHODS: The influence of dynamic shear stresses on primary hemostasis by single or multiple passes through left ventricular assist devices was investigated...
October 22, 2018: International Journal of Artificial Organs
Kamal Asadipour, Nader Nezafati, Mohammad Sadegh Nourbakhsh, Masoud Hafezi-Ardakani, Saleh Bohlooli
In the present study, the effect of adding different concentrations of silicon on physical, mechanical and biological properties of a synthesized aqueous precipitated eggshell-derived hydroxyapatite (e-HA) was evaluated. No secondary phases were detected by X-ray diffraction for the specimens e-HA and e-HA containing silicon (Si-e-HAs) before and after heating at 1200°C. A reduction in the crystallite size and a-axis as well as an increase in c-axis was occurred when silicon replacement was happened in the structure of e-HA...
October 22, 2018: International Journal of Artificial Organs
Shinya Chihara, Yoshiki Masuda, Hiroomi Tatsumi, Michiaki Yamakage
OBJECTIVE: We investigated the differences in biocompatibility pre- and post-dilution during continuous veno-venous hemofiltration in patients with sepsis, focusing on leukocyte and platelet function. PATIENTS AND METHODS: Subjects were 12 patients with septic shock who underwent veno-venous hemofiltration for acute kidney injury between March 2016 and September 2017. The first six patients received pre-dilution veno-venous hemofiltration, and the next six patients received post-dilution veno-venous hemofiltration...
October 2, 2018: International Journal of Artificial Organs
Konomi Togo, Yoshiaki Takewa, Nobumasa Katagiri, Yutaka Fujii, Akihiro C Yamashita, Eisuke Tastumi
INTRODUCTION: Recently, the use of veno-venous extracorporeal membrane oxygenation for adult patients with severe acute respiratory failure has increased. We previously investigated the optimal return cannula position; however, the optimal drainage cannula position has not yet been fully clarified. The aim of this study was to investigate the optimal drainage cannula position. METHODS: Veno-venous extracorporeal membrane oxygenation was performed in four adult goats (mean body weight 59...
September 17, 2018: International Journal of Artificial Organs
Nikhil A Huprikar, Matthew R Peterson, Jeffrey D DellaVolpe, Valerie G Sams, James H Lantry, Robert J Walter, Michael B Osswald, Kevin K Chung, Phillip E Mason
BACKGROUND: The prognosis of hematologic malignancies has improved over the past three decades. However, the prognosis in hematologic malignancies with severe acute respiratory distress syndrome has remained poor. Initial reports regarding the utility of extracorporeal membrane oxygenation in hematologic malignancies have been controversial, with limited evaluations of acute leukemia patients supported by extracorporeal membrane oxygenation. METHODS: We conducted a retrospective review of patients with acute leukemia who developed acute respiratory distress syndrome requiring veno-venous extracorporeal membrane oxygenation support at our facility from July 2015 through August 2017...
September 17, 2018: International Journal of Artificial Organs
Marcelo B Lopes, Luciana F Silva, Marina As Dantas, Cacia M Matos, Gildete B Lopes, Antonio A Lopes
OBJECTIVE: To investigate associations of sex-age-specific handgrip strength by a dynamometer with all-cause mortality and the percent excess risk explained (%ERE) by comorbidities and nutritional indicators in incident maintenance hemodialysis patients. METHODS: Prospective cohort of 413 adult patients (165 women, 248 men, 299 <60 years and 114 ⩾60 years) with <6 months (82% <3 months) on dialysis enrolled in PROHEMO in Salvador, Brazil. Low and high handgrip strength groups were based on sex-age-specific cutoffs (17...
September 11, 2018: International Journal of Artificial Organs
Adam Uslu, Veli Kursat Cayhan, Cenk Simsek, Ahmet Aykas, Murat Karatas, Ismail Can Tarcan, Gokalp Okut, Erhan Tatar
Late ureteral stenosis following kidney transplantation needs immediate correction in order to protect allograft function and requires a complicated surgical procedure. In this study, we present the long-term results of tubular bladder reconfiguration and cystopyelostomy (tubular vesicopyelostomy), an innovative and practical procedure for the management of long-segment ureteric stenosis (types 2 and 3) after transplantation. Between 2002 and 2017, 722 kidney transplant patients were monitored at the University of Medical Sciences, Bozyaka Organ Transplantation and Research Center...
September 5, 2018: International Journal of Artificial Organs
Roman Major, Malgorzata Gonsior, Marek Sanak, Marcin Kot, Roman Kustosz, Juergen M Lackner
PURPOSE: The main goal of this work was to develop haemocompatibile thin film materials dedicated to novel flexible mechanical heart valves intended for pulsatile ventricle assist devices. METHODS: The studies performed have led to the selection of a material for the surface modification of the metallic scaffold. Haemocompatible, biofunctional, ultra-elastic, thin carbon-based coatings were proposed. The surface was designed to eliminate thrombogenic and microbial construction by a reduction in turbulence and sufficient washing of the biofunctional-adapted surfaces, thus allowing for extended use for temporary heart support...
August 24, 2018: International Journal of Artificial Organs
Nobuo Watanabe, Takahiro Shimada, Masaya Hakozaki, Ryohei Hara
To elucidate development of shear-induced damage in erythrocytes, it is necessary to visualize erythrocytes under high-shear flow. Therefore, we prototyped a special shear flow chamber with a counter-rotating mechanism consisting of a transparent acrylic cone and a glass plate. The flow chamber was mounted on an inverted microscope and illuminated by a 350-W metal halide lamp. This experimental system made it possible for a digital video camera to record through the microscopes' objective lens the rheological behavior in shear flow of erythrocytes diluted in highly viscous polyvinyl pyrrolidone...
August 21, 2018: International Journal of Artificial Organs
Aaron Strumwasser, Joshua M Tobin, Reynold Henry, Chrissy Guidry, Caroline Park, Kenji Inaba, Demetrios Demetriades
INTRODUCTION: Limited options exist for cardiovascular support of the trauma patient in extremis. This patient population offers challenges that are often considered insurmountable. This article identifies a heterogeneous group of trauma patients in extremis who may benefit from extracorporeal membrane oxygenation. METHODS: Data were sourced from the medical records of all patients placed on extracorporeal membrane oxygenation following trauma at a Level I Trauma Center between 1 December 2016 and 1 December 2017...
August 17, 2018: International Journal of Artificial Organs
Sinduja Suresh, Oleksandr Gryshkov, Birgit Glasmacher
INTRODUCTION: This article explores the effect of horizontal and vertical setups on blend electrospinning with two polymers having vastly different properties - poly-ε-caprolactone and gelatin, and subsequent effect of the resulting microstructure on viability of seeded cells. METHODS: Poly-ε-caprolactone and gelatin of varying blend concentrations were electrospun in horizontal and vertical setup orientations. NIH 3T3 fibroblasts were seeded on these scaffolds to assess cell viability changes in accordance with change in microstructure...
November 2018: International Journal of Artificial Organs
Mauro Pietribiasi, Alicja Wójcik-Załuska, Wojciech Załuska, Jacek Waniewski
The filtration coefficient in the Starling equation is an important determinant of plasma refilling during hemodialysis. A method for calculating from clinical data an estimate of the filtration coefficient, called the refilling coefficient, was proposed in the past. The assumption behind this method was that the only drive for refilling is the increase in plasma oncotic pressure, and the remaining Starling forces have negligible effect. The refilling coefficient was observed to decrease during hemodialysis, and this was interpreted as a change in the filtration coefficient...
November 2018: International Journal of Artificial Organs
Alessandra Molteni, Marc Mueller
No abstract text is available yet for this article.
November 2018: International Journal of Artificial Organs
Anna M Stecka, Tomasz Gólczewski, Elżbieta M Grabczak, Krzysztof Zieliński, Marcin Michnikowski, Monika Zielińska-Krawczyk, Piotr Korczyński, Rafał Krenke
PURPOSES: Some controversies exist on the effect of therapeutic thoracentesis (TT) on arterial blood oxygen tension. The aim of this study was to evaluate this issue using a previously developed virtual patient. METHODS: The analysis was based and supported by clinical data collected during 36 TT. Pleural pressure and transcutaneous oxygen and carbon dioxide pressures (PtcO2 and PtcCO2 ) were measured during pleural fluid withdrawal. Arterial blood oxygen tension and arterial CO2 tension (PaO2 and PaCO2 ) were analysed in simulations that mimicked TT...
November 2018: International Journal of Artificial Organs
Dominica Py Khoo, Andrew N Cookson, Harinderjit S Gill, Katharine H Fraser
Despite the evolution of ventricular assist devices, ventricular assist device patients still suffer from complications due to the damage to blood by fluid dynamic stress. Since rotary ventricular assist devices are assumed to exert mainly shear stress, studies of blood damage are based on shear flow experiments. However, measurements and simulations of cell and protein deformation show normal and shear stresses deform, and potentially damage, cells and proteins differently. The aim was to use computational fluid dynamics to assess the prevalence of normal stress, in comparison with shear stress, in rotary ventricular assist devices...
November 2018: International Journal of Artificial Organs
Theresa Gärtner, Efthymios Beropoulis, Regina Wendl, Jasmin S Hanke, Günes Dogan, Anamika Chatterjee, Axel Haverich, Giovanni Torsello, Jan D Schmitto, Theodosios Bisdas, Christina Feldmann
INTRODUCTION: Pump thrombosis of left ventricular assist devices remains a devastating complication with high morbidity and mortality. Despite the improvements made, the matter affects many patients and the treatment options are limited to thrombolysis and surgical replacement. An alternative approach using the aspiration Indigo catheter was tested. METHODS: An Indigo thrombectomy catheter was used within an in vitro model to assess the direct aspiration of prefabricated clots from three different positions within the HeartWare HVAD (inlet, outlet, and housing)...
November 2018: International Journal of Artificial Organs
Caglar Ozturk, I Basar Aka, Ismail Lazoglu
AIMS: Impeller design has a significant impact on the overall performance of a blood pump. In this study, the effect of the blade curvature was investigated by performing in silico and in vitro studies on a recently developed centrifugal blood pump. METHODS: A computational fluid dynamics study was performed for the flow rates of 3-5 L/min at 2000 r/min. The computational fluid dynamics model was also applied on the US Food and Drug Administration (FDA) benchmark blood pump to validate our computational method...
November 2018: International Journal of Artificial Organs
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