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International Journal of Artificial Organs

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https://www.readbyqxmd.com/read/29783867/virtual-stenting-of-intracranial-aneurysms-a-pilot-study-for-the-prediction-of-treatment-success-based-on-hemodynamic-simulations
#1
Philipp Berg, Sylvia Saalfeld, Gábor Janiga, Olivier Brina, Nicole M Cancelliere, Paolo Machi, Vitor M Pereira
Endovascular treatment of intracranial aneurysms using flow-diverting devices has revolutionized the treatment of large and complex lesions due to its minimally invasive nature and potential clinical outcomes. However, incomplete or delayed occlusion and persistent intracranial aneurysm growth are still an issue for up to one-third of the patients. We evaluated two patients with intracranial aneurysm located at the internal carotid artery who were treated with flow-diverting devices and had opposite outcomes...
May 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29781355/development-and-biological-validation-of-a-cyclic-stretch-culture-system-for-the-ex-vivo-engineering-of-tendons
#2
Manuela Teresa Raimondi, Matteo Laganà, Claudio Conci, Michele Crestani, Alessia Di Giancamillo, Francesca Gervaso, Daniela Deponti, Federica Boschetti, Michele M Nava, Chiara Scandone, Cinzia Domeneghini, Alessandro Sannino, Giuseppe M Peretti
INTRODUCTION: An innovative approach to the treatment of tendon injury or degeneration is given by engineered grafts, made available through the development of bioreactors that generate tendon tissue in vitro, by replicating in vivo conditions. This work aims at the design of a bioreactor capable of applying a stimulation of cyclic strain on cell constructs to promote the production of bioartificial tissue with mechanical and biochemical properties resembling those of the native tissue...
May 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29761733/letter-regarding-the-article-by-aatif-et-al
#3
Omar Maoujoud, Mohammed Arrayhani, Nadir Zemraoui, Mohammed Asseraji
No abstract text is available yet for this article.
May 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29756538/comparison-between-three-in-vitro-methods-to-measure-magnesium-degradation-and-their-suitability-for-predicting-in-vivo-degradation
#4
Sara R Knigge, Birgit Glasmacher
A lot of research has been done in the field of magnesium-based implant material. This study is focused on finding an explanation for the large disparity in results from similar experiments in literature. The hypothesis is that many different measurement protocols are used to quantify magnesium degradation and this leads to inconsistent results. Cylindrical, pure magnesium samples were used for this study. The degradation took place in revised simulated body fluid at 37°C. Hydrogen evolution was measured to quantify the degradation...
May 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29749291/antithrombotic-therapy-in-pediatric-ventricular-assist-devices-multicenter-survey-of-the-european-excor-pediatric-investigator-group
#5
Oliver Miera, Katharina L Schmitt, Hakan Akintuerk, Angele Boet, Robert Cesnjevar, Teresa Chila, Thilo Fleck, Ranny Goldwasser, Luis G Guereta, Beatrice Heineking, Juergen Hoerer, Alexander Horke, Tain Y Hsia, Michael Huebler, Andrzej Kansy, Ann Karimova, Bohdan Maruszewski, Constancio Medrano, Szymon Pawlak, Zdenka Reinhardt, Birgitta Romlin, Eugen Sandica, Florian Schmidt, René Schramm, Martin Schweiger, Joanna Śliwka, Brigitte Stiller, Josef Thul, Antonio Amodeo
OBJECTIVES: Mechanical circulatory support for pediatric heart failure patients with the Berlin Heart EXCOR ventricular assist system is the only approved and established bridging strategy for recovery or heart transplantation. In recent years, the burden of thromboembolic events has led to modifications of the recommended antithrombotic therapy. Therefore, we aimed to assess modifications of antithrombotic practice among the European EXCOR Pediatric Investigator Group members. METHODS: We sent a questionnaire assessing seven aspects of antithrombotic therapy to 18 European hospitals using the EXCOR device for children...
May 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29707988/purification-processes-of-xenogeneic-bone-substitutes-and-their-impact-on-tissue-reactions-and-regeneration
#6
Zeljka Perić Kačarević, Faraz Kavehei, Alireza Houshmand, Jörg Franke, Ralf Smeets, Denis Rimashevskiy, Sabine Wenisch, Reinhard Schnettler, Ole Jung, Mike Barbeck
Xenogeneic bone substitute materials are widely used in oral implantology. Prior to their clinical use, purification of the former bone tissue has to be conducted to ensure the removal of immunogenic components and pathogens. Different physicochemical methods are applied for purification of the donor tissue, and temperature treatment is one of these methods. Differences in these methods and especially the application of different temperatures for purification may lead to different material characteristics, which may influence the tissue reactions to these materials and the related (bone) healing process...
April 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29642755/successful-treatment-of-ventricular-arrhythmic-storm-with-percutaneous-coronary-intervention-and-catheter-ablation-in-a-patient-with-left-ventricular-assist-device
#7
Nihat Firat Sipahi, Arash Mehdiani, Diyar Saeed, Udo Boeken, Hisaki Makimoto, Artur Lichtenberg, Hannan Dalyanoglu
INTRODUCTION: Ventricular arrhythmias are common in patients with advanced heart failure, which may also persist after sufficient intensive therapy for heart failure even with a left ventricular assist device. Although most ventricular arrhythmias have no hemodynamic relevance during left ventricular assist device support, some patients suffer from right ventricular decompensation due to ventricular arrhythmias resulting in severe hemodynamic deterioration and poor clinical outcomes. METHODS: We describe herein an left ventricular assist device patient with refractory ventricular arrhythmic storm early after left ventricular assist device implantation...
April 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29642725/comparison-of-methods-to-estimate-haemodialysis-urea-clearance
#8
Ahmed Mohamed, Andrew Davenport
INTRODUCTION: Dialysis adequacy is traditionally measured by monthly blood urea sampling and calculating sessional Kt/Vurea. Modern dialysis machines can estimate clearances each session, so we wished to compare online measurements with standard Kt/Vurea. METHODS: Urea clearance was estimated by intermittent changes in effective ionic dialysance and by continuous ultraviolet light absorption spent during the mid-week dialysis session. Total body water was calculated by the Watson equation and measured by multifrequency bioimpedance...
April 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29614899/biopolymer-based-strategies-in-the-design-of-smart-medical-devices-and-artificial-organs
#9
Lina Altomare, Lorenzo Bonetti, Chiara E Campiglio, Luigi De Nardo, Lorenza Draghi, Francesca Tana, Silvia Farè
Advances in regenerative medicine and in modern biomedical therapies are fast evolving and set goals causing an upheaval in the field of materials science. This review discusses recent developments involving the use of biopolymers as smart materials, in terms of material properties and stimulus-responsive behavior, in the presence of environmental physico-chemical changes. An overview on the transformations that can be triggered in natural-based polymeric systems (sol-gel transition, polymer relaxation, cross-linking, and swelling) is presented, with specific focus on the benefits these materials can provide in biomedical applications...
April 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29595085/immunosuppressive-and-antiviral-treatment-of-hepatitis-c-virus-associated-glomerular-disease-a-long-term-follow-up
#10
Fabrizio Fabrizi, Alessio Aghemo, Pietro Lampertico, Mirella Fraquelli, Donata Cresseri, Gabriella Moroni, Patrizia Passerini, Francesca M Donato, Piergiorgio Messa
BACKGROUND: The evidence in the medical literature on the treatment of hepatitis C virus-associated glomerular disease is extremely limited. The advent of nonconventional immunosuppressive agents and direct-acting antivirals promises high efficacy and safety. AIMS: We conducted an open-label, single-arm clinical study to examine the efficacy and safety of a combined approach for hepatitis C virus-associated glomerular disease. METHODS: In the first phase of the study, patients with hepatitis C virus-associated glomerular disease received interferon-based antiviral therapy and immunosuppressive agents; since 2013, interferon-free antiviral therapy was adopted and novel immunosuppressants (including B-cell depleting agents and mycophenolate mofetil) or immunomodulators (ribavirin) were choiced...
March 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29582685/-real-life-experience-with-direct-acting-antiviral-agents-for-hepatitis-c-virus-in-end-stage-renal-disease
#11
Rebeca García-Agudo, Sami Aoufi-Rabih, Mercedes Salgueira-Lazo, Carmen González-Corvillo, Fabrizio Fabrizi
BACKGROUND AND AIMS: The advent of direct-acting antiviral agents promises to change the management of hepatitis C in patients with end-stage renal disease, a patient group where the treatment of hepatitis C was historically challenging. We investigated the safety and efficacy of all-oral, interferon-free direct-acting antiviral agents for the treatment of hepatitis C in a 'real-world' group of patients with end-stage renal disease. METHODS: We performed a single-arm, multi-centre study in a cohort (n=30) of patients with advanced chronic kidney disease (mostly on dialysis) who underwent antiviral therapy with direct-acting antiviral agents...
March 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29577795/regional-citrate-calcium-anticoagulation-during-polymyxin-b-hemoperfusion-a-case-series
#12
Francesco Forfori, Etrusca Brogi, Anna Sidoti, Martina Giraudini, Gianpaola Monti, Nadia Zarrillo, Vincenzo Cantaluppi, Claudio Ronco
INTRODUCTION: So far, only heparin-based anticoagulation has been proposed during polymyxin-B hemoperfusion. However, postsurgical septic patients can be at high risk of bleeding due to either surgical complications or septic coagulation derangement. Consequently, heparin should not represent in some cases the anticoagulation regimen of choice in this type of patients. METHODS AND RESULTS: We present a case series of four postsurgical septic patients treated with polymyxin-B hemoperfusion using regional citrate anticoagulation...
March 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29562805/postnatal-dilatation-of-umbilical-cord-vessels-and-its-impact-on-wall-integrity-prerequisite-for-the-artificial-placenta
#13
Jenny Peng, Niels Rochow, Mohammadhossein Dabaghi, Radenka Bozanovic, Jan Jansen, Dragos Predescu, Bryon DeFrance, Sau-Young Lee, Gerhard Fusch, Ponnambalam Ravi Selvaganapathy, Christoph Fusch
INTRODUCTION: A lung assist device, which acts as an artificial placenta, can provide additional gas exchange for preterm and term newborns with respiratory failure. The concept of the lung assist device requires a large bore access via umbilical vessels to allow pumpless extracorporeal blood flow rates up to 30 mL/kg/min. After birth, constricted umbilical vessels need to be reopened for vascular access. The objective is to study the impact of umbilical vessel expansion on vessel integrity for achieving large bore access...
March 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29562797/association-of-lean-body-mass-with-nutritional-parameters-and-mortality-in-hemodialysis-patients-a-long-term-follow-up-clinical-study
#14
Dong Chi Zhou, Xiu Hong Yang, Xiao Li Zhan, Yan Hong Gu, Li Li Guo, Hui Min Jin
OBJECTIVE: This study aimed to evaluate the correlation between lean body mass (LBM) and nutritional status in hemodialysis (HD) patients to better predict their long-term prognosis. METHODS: Anthropometric body measurements and biochemical parameters were recorded from 222 patients on maintenance hemodialysis (MHD) at the Shanghai Pudong Hospital Hemodialysis Center. LBM was calculated using the serum creatinine index (LBM-SCR), mid-arm muscle circumference (LBM-MAMC), and dominant-arm hand-grip strength (LBM-HGS)...
June 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29562790/role-of-computed-tomography-angiography-for-heartmate-ii-left-ventricular-assist-device-thrombosis
#15
Sarah N Yu, Jiho Han, Koji Takeda, Jonathan N Ginns, Paul A Kurlansky, Arthur R Garan, Melana Yuzefpolskaya, Veli K Topkara, Paolo C Colombo, Yoshifumi Naka, Hiroo Takayama
INTRODUCTION: Device thrombosis is one of the most devastating complications of HeartMate II left ventricular assist devices. The purpose of this study is to assess the anatomical properties that the inflow and outflow computed tomography angiography provides in assessing for left ventricular assist device thrombosis, as well as their impact on clinical management and postoperative outcomes. METHODS: Between April 2010 and December 2016, 22 patients who received a HeartMate II left ventricular assist device implantation were readmitted for suspected device thrombosis and underwent a computed tomography angiography for workup...
June 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29739308/beat-von-albertini-lifetime-search-for-increased-dialysis-treatment-efficiency-an-obituary
#16
Jörg Vienken, Beat Walpoth
No abstract text is available yet for this article.
May 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29562813/role-of-wnt-signaling-during-inflammation-and-sepsis-a-review-of-the-literature
#17
Khosrow Siamak Houschyar, Malcolm P Chelliah, Susanne Rein, Zeshaan N Maan, Kristian Weissenberg, Dominik Duscher, Ludwik K Branski, Frank Siemers
Despite the development of modern intensive care and new antimicrobial agents, the mortality of patients with severe sepsis and septic shock remains high. Systemic inflammation is a consequence of activation of the innate immune system. It is characterized by the intravascular release of proinflammatory cytokines and other vasoactive mediators, with concurrent activation of innate immune cells. The Wnt signaling pathway plays a critical role in the development of multicellular organisms. Abnormal Wnt signaling has been associated with many human diseases, ranging from inflammation and degenerative diseases to cancer...
May 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29562808/prospective-analysis-of-bleeding-events-in-left-ventricular-assist-device-patients
#18
Saadia Sherazi, Peter Kouides, Charles Francis, Charles Julian Lowenstein, Majed Refaai, Grace Conley, Brent Alan Johnson, Eugene Muchnik, Susan Lien, Howard Todd Massey, Jeffrey Dean Alexis
BACKGROUND: Bleeding is a major cause of morbidity in patients with continuous flow left ventricular assist devices (LVADs). We sought to identify clinical predictors of bleeding within the first year of LVAD implantation. METHODS: A prospective study was performed on 30 patients with HeartMate II implantation at the University of Rochester Medical Center, Rochester, New York, United States. Blood was collected within 1 week before implantation, and at 1, 3, and 30 ± 10 days after implantation...
May 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29558840/symptoms-of-massive-cardiac-tamponade-during-support-of-biventricular-assist-device
#19
Mosab Al Shakaki, Angelo M Dell'Aquila, Andreas Rukosujew
Typical symptoms of cardiac tamponade are jugular venous distension, pulsus paradoxus, hypotension, and rest dyspnea. However, these clinical symptoms can be masked in patients with ventricular assist device and even more in patients supported with a biventricular-HeartWare ventricular assist device. Hereby, we report the case of a 30-year-old man supported with a biventricular-HeartWare ventricular assist device, who underwent a computed tomography scan due to suspect of ventricular assist device thrombosis...
May 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29546777/luminex-%C3%A2-xmap-%C3%A2-technology-is-an-effective-strategy-for-high-definition-human-leukocyte-antigen-typing-of-cord-blood-units-prior-to-listing
#20
Marco Guarene, Carla Badulli, Anna L Cremaschi, Ilaria Sbarsi, Rosalia Cacciatore, Carmine Tinelli, Annamaria Pasi, Paola Bergamaschi, Cesare G Perotti
INTRODUCTION: Allele-level donor-recipient match at HLA-A, HLA-B, HLA-C and HLA-DRB1 loci impacts the outcome after cord blood transplantation for hematologic malignancies and modifies the strategy of donor selection. High definition of both class I and II HLA loci at time of listing is a way to improve the attractiveness of cord blood bank inventories, reducing the time for donor search and procurement and simplifying donor choice, in particular, for patients of non-European heritage...
May 2018: International Journal of Artificial Organs
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