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International Journal of Artificial Organs

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https://www.readbyqxmd.com/read/28222209/effect-of-different-intermediary-bases-on-microleakage-of-a-restorative-material-in-class-ii-box-cavities-of-primary-teeth
#1
Faika Y Abdelmegid, Fouad S Salama, Waleed M Al-Mutairi, Saud K Al-Mutairi, Sultan O Baghazal
INTRODUCTION: The aim of this in vitro study was to assess and compare the effect of different intermediary bases on microleakage between tooth and a nanocomposite interface in Class II box cavities in primary teeth. METHODS: Standard Class II box cavities were prepared in 52 primary molars and randomly divided into 9 groups according to the intermediary base used (Multicore Flow, Fuji II LC, SDR, Smart Dentin Replacement, and Biodentine). All specimens were subjected to thermocycling and prepared for microleakage testing and evaluation...
February 21, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28222208/effect-of-thiolated-glycosaminoglycans-on-the-behavior-of-breast-cancer-cells-toward-the-development-of-in-vitro-models-of-cancer
#2
Alexander Köwitsch, Ankur Chhalotre, Thomas Groth
PURPOSE: The influence of extracellular matrix components like glycosaminoglycans (GAG) or adhesive proteins on the migration of cancer cells and the progression of tumorigenesis remains a challenging task. Therefore, this study aims to give insight into the interaction of cancer cells exhibiting different metastatic potential (MDA-MB-231, MDA-MB-468) with surface immobilized GAG interacting with serum proteins like fibronectin. METHODS: Model substrata were covalently coated with different thiolated GAG (hyaluronan (HA), chondroitin sulfate (CS), heparin (Hep)) and investigated for the adsorption of fibronectin (FN) with surface plasmon resonance...
February 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28222207/impact-of-the-type-of-dialysis-membranes-on-the-circulating-concentration-of-markers-of-vitamin-d-metabolism
#3
Etienne Cavalier, Pablo U Torres, Bernard E Dubois, Nicole Smelten, Hans Pottel, Jean-Marie Krzesinski, Pierre Delanaye
INTRODUCTION: Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend vitamin D supplementation in hemodialyzed patients to monitor 25(OH)-vitamin D 25(OH)D levels. However, patient-to-patient inconsistency can be observed in response to the treatment. In this study, we aimed to evaluate the impact of the dialysis membrane on 25(OH)D, albumin (Alb) and vitamin D-binding protein (VDBP), the major players of vitamin D transport and storage. MATERIAL AND METHODS: Alb (Cobas), VDBP (R&D) and 25(OH)D (liquid chromatography-tandem mass spectrometry) were measured in 75 patients before and after a 4-hour dialysis session...
February 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28218355/mechanisms-of-endothelial-activation-in-sepsis-and-cell-culture-models-to-study-the-heterogeneous-host-response
#4
Tanja Eichhorn, Michael B Fischer, Viktoria Weber
Sepsis is currently viewed as a fundamental disintegration of control functions from intracellular signalling to immunoregulatory and neuroendocrine mechanisms. The immediate threat in sepsis is invasive infection, and the need to activate immune defense mechanisms to clear the pathogen before irreparable damage occurs. In the process of pathogen elimination, however, the systemic host response to infection may cause collateral damage to the endothelium and may lead to the destruction of host tissues.A number of experimental models have been developed to monitor endothelial activation and to study endothelial dysfunction under septic conditions...
February 13, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28218353/biomimetic-principles-to-develop-blood-compatible-surfaces
#5
Vladislav Semak, Michael B Fischer, Viktoria Weber
Functionalized biomaterial surface patterns capable of resisting nonspecific adsorption while retaining their bioactivity are crucial in the advancement of biomedical technologies, but currently available biomaterials intended for use in whole blood frequently suffer from nonspecific adsorption of proteins and cells, leading to a loss of activity over time. In this review, we address two concepts for the design and modification of blood compatible biomaterial surfaces, zwitterionic modification and surface functionalization with glycans - both of which are inspired by the membrane structure of mammalian cells - and discuss their potential for biomedical applications...
February 13, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28218351/the-role-of-ionized-calcium-and-magnesium-in-regional-citrate-anticoagulation-and-its-impact-on-inflammatory-parameters
#6
Karin Strobl, Stephan Harm, Viktoria Weber, Jens Hartmann
INTRODUCTION: Regional anticoagulation with citrate has been found to be superior to heparin in terms of biocompatibility, and numerous protocols for regional citrate anticoagulation have been published, while a consensus on the target concentration of ionized calcium (Ca2+) in the extracorporeal circuit has not been reached so far. METHODS: The aim of this in vitro study was to assess the impact of different citrate concentrations on coagulation as well as on complement activation and cytokine secretion and to investigate the impact of ionized magnesium (Mg2+) on these parameters...
February 13, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28218354/dialysis-access-infections-and-hospitalisations-in-unplanned-dialysis-start-patients-results-from-the-options-study
#7
Anna Machowska, Mark D Alscher, Satyanarayana Reddy Vanga, Michael Koch, Michael Aarup, Abdul R Qureshi, Bengt Lindholm, Peter Rutherford
INTRODUCTION: Unplanned dialysis start (UPS) associates with worse clinical outcomes, higher utilisation of healthcare resources, lower chances to select dialysis modality and UPS patients typically commenced in-centre haemodialysis (HD) with central venous catheter (CVC). We evaluated patient outcomes and healthcare utilisation depending on initial dialysis access (CVC or PD catheter) and subsequent pathway of UPS patients. METHODS: In this study patient demographics, access procedures, hospitalisations, and major infectious complications were analysed over 12 months in 270 UPS patients...
February 11, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28218352/concomitant-pulsatile-and-continuous-flow-vad-in-biventricular-and-univentricular-physiology-a-comparison-study-with-a-numerical-model
#8
Arianna Di Molfetta, Gianfranco Ferrari, Roberta Iacobelli, Sergio Filippelli, Paolo Guccione, Libera Fresiello, Gianluigi Perri, Antonio Amodeo
INTRODUCTION: To develop and test a lumped parameter model to simulate and compare the effects of the simultaneous use of continuous flow (CF) and pulsatile flow (PF) ventricular assist devices (VADs) to assist biventricular circulation vs. single ventricle circulation in pediatrics. METHODS: Baseline data of 5 patients with biventricular circulation eligible for LVAD and of 5 patients with Fontan physiology were retrospectively collected and used to simulate patient baselines...
February 11, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28194749/apical-transportation-of-proglider-and-protaper-next-activated-with-different-motions
#9
Hakan Arslan, Damla O Kırıcı, Ahmet D Uygun, Ruslan Khalilov, Yahya Güven, Ertuğrul Karataş, Halit Aladağ
PURPOSE: The aim of this study was to investigate the apical transportation of the ProGlider and ProTaper Next using 3 different motions (150° clockwise [CW]; 0° counter clockwise [CCW], 270° CW-30° CCW; and [360° CW] continuous rotation). MATERIALS AND METHODS: 36 simulated, curved, plastic training blocks were randomly distributed into 3 groups for treatment according to the movement kinematics used for ProGlider (Dentsply Maillefer) followed by ProTaper Next (Dentsply Maillefer) instruments (n = 12): 150° CW-30° CCW, 270° CW-30° CCW, and 360° CW (continuous rotation)...
February 11, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28194748/artificial-organs-current-status-and-future-directions
#10
Andrea Remuzzi
No abstract text is available yet for this article.
February 11, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28218356/a-new-integrated-technique-for-the-supportive-treatment-of-sepsis
#11
Jens Hartmann, Stephan Harm
Although there has been continuous, intensive research for many years in the field of sepsis treatment, currently available treatment options are limited, and there is still a lack of systems that efficiently remove endotoxins as well as mediators. Here, we discuss a newly developed, integrated technique that combines different aspects for their use in extracorporeal blood purification for the supportive treatment of liver failure and sepsis.
February 8, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28165586/efficacy-of-postoperative-polymyxin-b-hemoperfusion-in-secondary-peritonitis-patients-with-septic-shock-a-propensity-matched-analysis
#12
Kuo-Ching Yuan, Shang-Yu Wang, Ming-Chin Yu, Yu-Pao Hsu, Heng-Chih Pan, Yung-Chang Chen
INTRODUCTION: Severe sepsis and septic shock is still a challenge. Polymyxin B hemoperfusion (PMX) is a device designed to remove circulating endotoxin by adsorption, which is reported to improve treatment outcomes. This study aimed to further verify the efficacy of PMX on postoperative, peritonitis, septic shock patients. METHODS: This study prospectively analyzed 20 of 155 patients who presented with postoperative septic shock and were treated with PMX in a single institute during the period March 2013 to September 2014 (Clinical Trial Protocol number: ChiCTR-ONC-16008160)...
February 4, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28165585/hepatitis-c-virus-infection-in-maintenance-hemodialysis-patients-recommendations-for-diagnostics-and-treatment
#13
Pavlina Dzekova-Vidimliski, Aleksandar Sikole
Hepatitis C virus (HCV) infection is highly prevalent among patients treated with maintenance hemodialysis and is an important cause of morbidity and mortality. It is necessary to determine the HCV genotype and the viral load to monitor the clinical and laboratory features and to establish an optimal antiviral treatment strategy. Antiviral treatments are presented with a standard interferon-based regimen and new direct-acting antiviral agents. The advent of direct-acting antivirals has improved the efficacy and safety of HCV treatment for most patients, even in difficult-to-treat populations such as patients on hemodialysis...
February 1, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28165584/triblock-copolymers-based-on-%C3%AE%C2%B5-caprolactone-and-trimethylene-carbonate-for-the-3d-printing-of-tissue-engineering-scaffolds
#14
Aysun Güney, Jos Malda, Wouter J A Dhert, Dirk W Grijpma
BACKGROUND: Biodegradable PCL-b-PTMC-b-PCL triblock copolymers based on trimethylene carbonate (TMC) and ε-caprolactone (CL) were prepared and used in the 3D printing of tissue engineering scaffolds. Triblock copolymers of various molecular weights containing equal amounts of TMC and CL were prepared. These block copolymers combine the low glass transition temperature of amorphous PTMC (approximately -20°C) and the semi-crystallinity of PCL (glass transition approximately -60°C and melting temperature approximately 60°C)...
February 1, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28127737/new-insights-into-the-pros-and-cons-of-cross-linking-decellularized-bioartificial-organs
#15
Kamal H Hussein, Kyung-Mee Park, Yun-Suk Lee, Jae-Seok Woo, Byung-Jae Kang, Ki-Young Choi, Kyung-Sun Kang, Heung-Myong Woo
ABSTRACTDecellularization is an attractive method for scaffold designing in regenerative medicine. The resulting extracellular matrix (ECM) consists of structural proteins such as collagen and elastin, growth factors, and glycosaminoglycans, which can direct site-appropriate remodeling after in vivo implantation. Mainly, collagen and elastin of ECM are exposed to the enzymatic biodegradation in the host. To control the biodegradation process, treatment of decellularized tissue by a cross-linking agent is required...
January 25, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28127739/phosphate-equilibration-rate-and-daily-clearance-in-patients-on-capd-ccpd-and-apd
#16
Rafael Gomez, Jacek Waniewski, Adelaida Zapata, Mauro Pietribiasi, Bengt Lindholm
BACKGROUND: Criteria for how to assess removal rate of inorganic phosphorous (iP) in peritoneal dialysis (PD) and whether iP removal differs between different PD modalities are debated. METHODS: In a cross-sectional study, 73 prevalent patients on continuous ambulatory PD (n = 16), continuous cyclic PD (n = 8) or automated PD (n = 49) with mean age 54 (range, 18-87) years, 46 males, underwent standard peritoneal equilibration test (PET) and 24-hour collection of dialysate with measurements of iP, urea and creatinine in all samples and bags...
January 24, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28127738/the-role-of-rankl-rank-opg-system-in-the-canine-model-of-hip-periprosthetic-infection-osteolysis
#17
Hao-Wei Zhang, Li Peng, Wen-Bo Li, Ke-Guan Song
PURPOSE: We aimed to investigate whether the RANKL/RANK/OPG system is associated with the incidence of periprosthetic osteolysis with septic loosening, and to investigate the differences of RANKL/RANK/OPG system expression in synovial fluid surrounding the normal and septic loosening hip prosthesis in canine models. METHODS: Twelve healthy adult mongrel canines were divided into two groups: experimental and control. Femoral head and stem replacements were conducted on the right side in both groups...
January 24, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28106226/applied-taguchi-method-for-fatigue-testing-of-customized-hip-implant
#18
Mangesh R Dharme, Abhaykumar M Kuthe, Tushar R Deshmukh
PURPOSE: Human activities generate stresses, which vary with time and may result in fatigue failure of the customized hip implant. This study aims to investigate fatigue testing of customized hip implants using the minimum number of experiments by the Taguchi method, for 147 patients. This study was also useful to determine the influential geometrical parameters on the fatigue safety factor of customized hip implants. METHODS: Horizontal offset (HO), vertical offset (VO) and neck shaft angle (NSA) of the hip joint of 147 patients were measured on computed tomography (CT) scanned images...
January 20, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28085173/impact-of-chlorhexidine-gluconate-intolerance-on-driveline-infection-during-chronic-heartmate-ii-left-ventricular-assist-device-support
#19
Andre Y Son, Louis H Stein, Abe DeAnda, Stuart D Katz, Deane E Smith, Alex Reyentovich, Leora B Balsam
PURPOSE: Driveline exit site (DLES) management following left ventricular assist device implantation is important for preventing driveline infection (DLI). While chlorhexidine gluconate (CHG) is generally recommended for DLES antisepsis, CHG intolerance can develop, resulting in a need for alternative antiseptics. We reviewed our institutional experience with DLES antisepsis methods in HeartMate II patients, comparing outcomes of patients with and without CHG intolerance. METHODS: Between October 2011 and March 2016, 44 patients underwent primary HeartMate II implantation...
January 12, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28085172/development-of-the-first-adult-respiratory-extracorporeal-membrane-oxygenation-center-in-croatia-under-emergency-circumstances
#20
Marko Kutleša, Bruno Baršić
INTRODUCTION: We report on the challenges of establishing a successful adult respiratory extracorporeal membrane oxygenation (ECMO) center in a developing country like Croatia under emergency conditions. We further introduce measures that would improve the outcome of patients treated with ECMO for respiratory failure at the national level. METHODS: 100 consecutive adult patients treated with venovenous (VV) ECMO for acute respiratory failure were enrolled to the database prospectively from October 2009 until June 2016...
January 12, 2017: International Journal of Artificial Organs
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