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International Journal of Artificial Organs

Marcelo B Lopes, Luciana F Silva, Marina As Dantas, Cacia M Matos, Gildete B Lopes, Antonio A Lopes
OBJECTIVE: To investigate associations of sex-age-specific handgrip strength by a dynamometer with all-cause mortality and the percent excess risk explained (%ERE) by comorbidities and nutritional indicators in incident maintenance hemodialysis patients. METHODS: Prospective cohort of 413 adult patients (165 women, 248 men, 299 <60 years and 114 ⩾60 years) with <6 months (82% <3 months) on dialysis enrolled in PROHEMO in Salvador, Brazil. Low and high handgrip strength groups were based on sex-age-specific cutoffs (17...
September 11, 2018: International Journal of Artificial Organs
Adam Uslu, Veli Kursat Cayhan, Cenk Simsek, Ahmet Aykas, Murat Karatas, Ismail Can Tarcan, Gokalp Okut, Erhan Tatar
Late ureteral stenosis following kidney transplantation needs immediate correction in order to protect allograft function and requires a complicated surgical procedure. In this study, we present the long-term results of tubular bladder reconfiguration and cystopyelostomy (tubular vesicopyelostomy), an innovative and practical procedure for the management of long-segment ureteric stenosis (types 2 and 3) after transplantation. Between 2002 and 2017, 722 kidney transplant patients were monitored at the University of Medical Sciences, Bozyaka Organ Transplantation and Research Center...
September 5, 2018: International Journal of Artificial Organs
Roman Major, Malgorzata Gonsior, Marek Sanak, Marcin Kot, Roman Kustosz, Juergen M Lackner
PURPOSE: The main goal of this work was to develop haemocompatibile thin film materials dedicated to novel flexible mechanical heart valves intended for pulsatile ventricle assist devices. METHODS: The studies performed have led to the selection of a material for the surface modification of the metallic scaffold. Haemocompatible, biofunctional, ultra-elastic, thin carbon-based coatings were proposed. The surface was designed to eliminate thrombogenic and microbial construction by a reduction in turbulence and sufficient washing of the biofunctional-adapted surfaces, thus allowing for extended use for temporary heart support...
August 24, 2018: International Journal of Artificial Organs
Anna M Stecka, Tomasz Gólczewski, Elżbieta M Grabczak, Krzysztof Zieliński, Marcin Michnikowski, Monika Zielińska-Krawczyk, Piotr Korczyński, Rafał Krenke
PURPOSES: Some controversies exist on the effect of therapeutic thoracentesis (TT) on arterial blood oxygen tension. The aim of this study was to evaluate this issue using a previously developed virtual patient. METHODS: The analysis was based and supported by clinical data collected during 36 TT. Pleural pressure and transcutaneous oxygen and carbon dioxide pressures (PtcO2 and PtcCO2 ) were measured during pleural fluid withdrawal. Arterial blood oxygen tension and arterial CO2 tension (PaO2 and PaCO2 ) were analysed in simulations that mimicked TT...
August 24, 2018: International Journal of Artificial Organs
Dominica Py Khoo, Andrew N Cookson, Harinderjit S Gill, Katharine H Fraser
Despite the evolution of ventricular assist devices, ventricular assist device patients still suffer from complications due to the damage to blood by fluid dynamic stress. Since rotary ventricular assist devices are assumed to exert mainly shear stress, studies of blood damage are based on shear flow experiments. However, measurements and simulations of cell and protein deformation show normal and shear stresses deform, and potentially damage, cells and proteins differently. The aim was to use computational fluid dynamics to assess the prevalence of normal stress, in comparison with shear stress, in rotary ventricular assist devices...
August 24, 2018: International Journal of Artificial Organs
Nobuo Watanabe, Takahiro Shimada, Masaya Hakozaki, Ryohei Hara
To elucidate development of shear-induced damage in erythrocytes, it is necessary to visualize erythrocytes under high-shear flow. Therefore, we prototyped a special shear flow chamber with a counter-rotating mechanism consisting of a transparent acrylic cone and a glass plate. The flow chamber was mounted on an inverted microscope and illuminated by a 350-W metal halide lamp. This experimental system made it possible for a digital video camera to record through the microscopes' objective lens the rheological behavior in shear flow of erythrocytes diluted in highly viscous polyvinyl pyrrolidone...
August 21, 2018: International Journal of Artificial Organs
Aaron Strumwasser, Joshua M Tobin, Reynold Henry, Chrissy Guidry, Caroline Park, Kenji Inaba, Demetrios Demetriades
INTRODUCTION: Limited options exist for cardiovascular support of the trauma patient in extremis. This patient population offers challenges that are often considered insurmountable. This article identifies a heterogeneous group of trauma patients in extremis who may benefit from extracorporeal membrane oxygenation. METHODS: Data were sourced from the medical records of all patients placed on extracorporeal membrane oxygenation following trauma at a Level I Trauma Center between 1 December 2016 and 1 December 2017...
August 17, 2018: International Journal of Artificial Organs
Leonid Goubergrits, Ulrich Kertzscher, Michael Lommel
Anatomic pathologies such as stenosed or regurgitating heart valves and artificial organs such as heart assist devices or heart valve prostheses are associated with non-physiological flow. This regime is associated with regions of spatially high-velocity gradients, high-velocity and/or pressure fluctuations as well as neighbouring regions with stagnant flow associated with high residence time. These hemodynamic conditions cause destruction and/or activation of blood components and their accumulation in regions with high residence time...
August 3, 2018: International Journal of Artificial Organs
David Itskoviz, Ben Ben Avraham, Hagar Banai, Irit Avni, Tuvia Ben Gal, Iris Dotan, Eyal Gal
INTRODUCTION: Suspected small bowel bleeding is frequently encountered in left ventricular assist device recipients and the identification of the culprit lesion may be challenging. Data regarding the safety and yield of small bowel capsule in the investigation of suspected small bowel bleeding are limited. We aimed to evaluate the safety and efficacy of small bowel video capsule endoscopy for the investigation of suspected small bowel bleeding among left ventricular assist device recipients...
August 3, 2018: International Journal of Artificial Organs
Antony P McNamee, Kieran Richardson, Jarod Horobin, Lennart Kuck, Michael J Simmonds
INTRODUCTION: Accumulating evidence demonstrates that subhaemolytic mechanical stresses, typical of circulatory support, induce physical and biochemical changes to red blood cells. It remains unclear, however, whether cell age affects susceptibility to these mechanical forces. This study thus examined the sensitivity of density-fractionated red blood cells to sublethal mechanical stresses. METHODS: Red blood cells were isolated and washed twice, with the least and most dense fractions being obtained following centrifugation (1500 g × 5 min)...
August 3, 2018: International Journal of Artificial Organs
Evrim Eliguzeloglu Dalkilic, Nazmiye Donmez, Magrur Kazak, Bugra Duc, Akif Aslantas
BACKGROUND: The aim of this study was to determine the Vickers hardness and water solubility of expired and non-expired shelf-life bulk-fill and conventional dental composite material. METHODS: Four different expired (E) (after 6 months) and non-expired (N) shelf-life composite resin materials (Clearfil Majesty ES-2 Enamel, Clearfil Majesty ES-2 Dentin, Tetric N-Ceram Bulk-Fill, and Tetric N-Ceram) were used. For each tested material, seven specimens were prepared and polymerized with a light curing unit...
July 30, 2018: International Journal of Artificial Organs
Zbigniew Tyfa, Dariusz Witkowski, Krzysztof Sobczak, Damian Obidowski, Krzysztof Jóźwik
INTRODUCTION: A constant growth in the population suffering from osteoporotic vertebral weakening is observed. As a result, vertebroplasty procedures become more and more common. Unfortunately, they may be associated with several complications occurring during bone cement injection, including its leakage or overheating of tissues. Despite several experimental studies, there is a lack of data related to random aeration of the bone cement. Therefore, the main objective of the following investigations was to emphasize that random aeration of the bone cement, and, consequently, a compressibility factor, could not be treated as a negligible factor during the vertebroplasty procedure and had to be taken into account in the development of the mathematical model...
July 18, 2018: International Journal of Artificial Organs
Theresa Gärtner, Efthymios Beropoulis, Regina Wendl, Jasmin S Hanke, Günes Dogan, Anamika Chatterjee, Axel Haverich, Giovanni Torsello, Jan D Schmitto, Theodosios Bisdas, Christina Feldmann
INTRODUCTION: Pump thrombosis of left ventricular assist devices remains a devastating complication with high morbidity and mortality. Despite the improvements made, the matter affects many patients and the treatment options are limited to thrombolysis and surgical replacement. An alternative approach using the aspiration Indigo catheter was tested. METHODS: An Indigo thrombectomy catheter was used within an in vitro model to assess the direct aspiration of prefabricated clots from three different positions within the HeartWare HVAD (inlet, outlet, and housing)...
July 1, 2018: International Journal of Artificial Organs
Caglar Ozturk, I Basar Aka, Ismail Lazoglu
AIMS: Impeller design has a significant impact on the overall performance of a blood pump. In this study, the effect of the blade curvature was investigated by performing in silico and in vitro studies on a recently developed centrifugal blood pump. METHODS: A computational fluid dynamics study was performed for the flow rates of 3-5 L/min at 2000 r/min. The computational fluid dynamics model was also applied on the US Food and Drug Administration (FDA) benchmark blood pump to validate our computational method...
July 1, 2018: International Journal of Artificial Organs
Michela Bozzetto, Paolo Brambilla, Stefano Rota, Bogdan Ene-Iordache, Sandro Sironi, Giuseppe Remuzzi, Andrea Remuzzi
INTRODUCTION: Autogenous arteriovenous fistula is the preferred vascular access for hemodialysis, but it has high rates of non-maturation and early failure due to vascular stenosis. Convincing evidence supports a key role of local hemodynamics in vascular remodeling, suggesting that unsteady and disturbed flow conditions may be related to stenosis formation in arteriovenous fistula. The purpose of our study was to explore the feasibility of coupling contrast-free magnetic resonance imaging and computational fluid dynamics in longitudinal studies to identify the role of local hemodynamic changes over time in inducing vessel wall remodeling in arteriovenous fistula...
July 1, 2018: International Journal of Artificial Organs
Lucía Gullón, Judit Gutiérrez-Gutiérrez, Robert T Sánchez Del Arco, Andrés Rivera, Ignacio Fernández, Juan F Del Cañizo
INTRODUCTION: Liver perfusion machines are close to becoming a reality in the transplantation field. However, depending on the techniques used and the goals pursued, their application is limited in the research field. Here, we present the entire development of a perfusion system with self-made engineering, completely autonomous controls, and a high degree of versatility that allows the design of different studies on liver functionality. METHODS: A user-friendly interface permits real-time monitoring and remote control by the devices within the circuit...
July 1, 2018: International Journal of Artificial Organs
Fedaa Al Halabi, Oleksandr Gryshkov, Antonia I Kuhn, Viktoria M Kapralova, Birgit Glasmacher
Polyvinylidene fluoride and its co-polymer with trifluoroethylene are promising biomaterials for supporting nerve regeneration processes because of their proven biocompatibility and piezoelectric properties that could stimulate cell ingrowth due to electrical activity upon mechanical deformation. This study reports the piezoelectric effect of electrospun polyvinylidene fluoride scaffolds in response to mechanical loading. An impact test machine was used to evaluate the generation of electrical voltage upon application of an impact load...
July 1, 2018: International Journal of Artificial Organs
Damian Obidowski, Piotr Reorowicz, Dariusz Witkowski, Krzysztof Sobczak, Krzysztof Jóźwik
BACKGROUND: A pneumatic paediatric ventricular assist device developed at the Foundation of Cardiac Surgery Development, Zabrze, equipped with valves based on J. Moll's design, with later modifications introduced at the Institute of Turbomachinery, Lodz University of Technology, was tested numerically and experimentally. The main aim of those investigations was to detect stagnation zones within the ventricular assist device and indicate advantages and limitations of both approaches. METHODS: In the numerical transient test, a motion of the diaphragm and discs was simulated...
October 2018: International Journal of Artificial Organs
Merve Çakırbay Tanış, Canan Akay, Handan Sevim
INTRODUCTION: The aim of this study was to evaluate the cytotoxic effect of various denture base materials following four different aging periods. METHODS: In total, 48 disc-shaped specimens per each group were prepared: Group I: acrylic resin polymerized in cool water and heated up to 100°C over 45 min and boiled for 15 min; Group II: acrylic resin polymerized under pressure in 40°C-45°C water bath for 10 min; Group III: autopolymerized hard relining resin Cold Liner Rebase; Group IV: autopolymerized hard relining resin Truliner; Group V: soft relining resin DentuSil...
October 2018: International Journal of Artificial Organs
Hugo Lo Pinto, Jérôme Allyn, Romain Persichini, Bruno Bouchet, Gilbert Brochier, Olivier Martinet, Caroline Brulliard, Dorothée Valance, Benjamin Delmas, Eric Braunberger, Laurence Dangers, Nicolas Allou
PURPOSE: Few data are available on the potential benefits and risks of red blood cell transfusion in patients undergoing extracorporeal membrane oxygenation. The aim of this study was to identify the determinants and prognosis of red blood cell transfusion in patients undergoing extracorporeal membrane oxygenation, with a special focus on biological parameters during extracorporeal membrane oxygenation treatment. METHODS: We conducted a single-center retrospective cohort study including all consecutive patients who underwent extracorporeal membrane oxygenation between January 2010 and December 2015...
October 2018: International Journal of Artificial Organs
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