Chao Li, Nanxin Li, Xingyu Chen, Xiaojuan Li, Chang Liu, Awn Abbas, Yueli Wang, Shuangcai Qi, Yifan Zhang, Dongbo Li, Wei Zhang, Gang Shu, Juchun Lin, Haohuan Li, Funeng Xu, Guangneng Peng, Hualin Fu
UNLABELLED: Objective Florfenicol(FF) is an excellent veterinary antibiotic, limited by poor solubility and poor bioavailability. SIGNIFICANCE: Here in, we aimed to explore the applicability of fast disintegrating tablets compressed from Florfenicol-loaded solid dispersions (FF-SD-FDTs) to improve the dissolution rate and oral bioavailability of Florfenicol. METHODS: Utilizing selecting appropriate preparation methods and carriers, the solid dispersions of Florfenicol (FF-SDs) were prepared by solvent evaporation and the fast disintegrating tablets (FF-SD-FDTs) were prepared by the direct compression (DC) method...
December 14, 2023: Drug Development and Industrial Pharmacy