journal
Journals Drug Development and Industria...

Drug Development and Industrial Pharmacy

https://read.qxmd.com/read/38318676/development-and-optimization-of-clitoria-teratea-synthesized-silver-nanoparticles-and-its-application-to-nanogel-systems-for-wound-healing
#21
JOURNAL ARTICLE
Richa Jain, Ruchi Singh, Reena Badhwar, Tinku Gupta, Harvinder Popli
Objective The present research deals with sequential optimization strategy based on Central Composite Design to optimize the process variables for efficient production of Clitoria teratea (CLT) synthesized silver nanoparticles (AgNPs) using biological synthesis. Methods: Two substantial factors influencing the dependent variables viz UV-Visible absorbance, Particle size, zeta potential and Polydispersity index (PDI) were identified as NaOH concentration, RH concentration, temperature as independent variables...
February 6, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38317433/development-of-pu-foam-dressings-loaded-with-extract-of-plectranthus-amboinicus-for-burn-wound-healing
#22
JOURNAL ARTICLE
Akhila Jain, Sindhu Abraham, Shwetha Krishnamurthy, Kesha Desai, Basavaraj Basappa Veerabhadraiah
OBJECTIVE: To develop Plectranthus amboinicus extract loaded Polyurethane foam dressing for burn wound healing. SIGNIFICANCE: Plectranthus amboinicus is traditionally used as an anti-inflammatory and wound healing agent. Its incorporation in a PU foam dressing will offer the dual benefits of foam dressing as well as the healing potential of P. amboinicus . METHODS: PU foam dressings were prepared and loaded with P. ambionicus leaf extract (PAE)...
February 5, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38305806/physicochemical-interaction-of-rifampicin-and-ritonavir-lopinavir-solid-dispersion-an-in-vitro-and-ex-vivo-investigation
#23
JOURNAL ARTICLE
Athira R Nair, Sai Krishna Anand Vullendula, Dani Lakshman Yarlagadda, Brahmam Bheemisetty, Swapnil J Dengale, Krishnamurthy Bhat
OBJECTIVE: To investigate the in-situ physicochemical interaction of Rifampicin and Ritonavir - Lopinavir Solid dispersion administered for the treatment of comorbid conditions i.e. Tuberculosis and HIV/AIDS. METHODS: pH-shift dissolution of Rifampicin (RIF) in presence of Ritonavir-Lopinavir solid dispersion (RL-SD) was carried out in USP phosphate buffer 6.8 and FaSSIF. Equilibrium and amorphous solubility were determined for the drugs. Pure drugs, their physical mixtures, and pH-shifted co-precipitated samples were characterized using DSC, PXRD, and FTIR...
February 2, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38305197/potential-anticancer-effect-of-free-and-nanoformulated-deferasirox-for-breast-cancer-treatment-in-vitro-and-in-vivo-evaluation
#24
JOURNAL ARTICLE
Nadeen Diaa Abdel-Wahab, Mohamed Fawzi Kabil, Ibrahim M El-Sherbiny, Mohamed F Salama, Gehad El-Sayed, El-Said El-Sherbini
Background: Breast cancer (BC) stands as the second leading cause of mortality among women worldwide. Many chemotherapeutic treatments for BC come with significant adverse effects. Additionally, BC is recognized as one of the most resistant forms of malignancy to treatment. Consequently, there exists a critical need for innovative therapeutic agents that are both highly effective and exhibit reduced toxicity and side effects for patients. Deferasirox (DFX), an iron-chelating drug approved by the FDA for oral use, emerges as a promising contender in the fight against BC proliferation...
February 2, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38265062/comparative-pharmacokinetic-evaluation-of-glimepiride-orodispersable-and-conventional-tablets-in-rabbits
#25
JOURNAL ARTICLE
Altaf Ur Rahman, Fazli Nasir, Muzna Ali Khattak, Talaya Hidayatullah, Sadia Pervez, Syeda Rabqa Zainab, Arbab Tahir, Shazma Gohar, Gul E Maryam, Waleed H Almalki
OBJECTIVES: Glimepiride Orodispersable Tablets (ODT) were prepared with the goal to have rapid onset of action and higher bioavailability with ease administration to individuals with swallowing difficulty to ameliorate patient compliance. SIGNIFICANCE: Glimepiride is a contemporary hypoglycaemic medication that belongs to the family of sulfonylurea derivatives. It is used in type 2 diabetes mellitus. Compliance adherence remains one of the limitations with the conventional drug delivery system especially in paediatric, geriatric, psychiatric, and travelling patients, for such population ODT provides a good alternate dosage form compared with Commercial Tablets...
January 24, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38235554/borneol-modified-docetaxel-plus-tetrandrine-micelles-for-treatment-of-drug-resistant-brain-glioma
#26
JOURNAL ARTICLE
Yang Liu, Jia-Yu Cai, Yang Liu, Lu Zhang, Rui-Bo Guo, Xue-Tao Li, Ling-Yue Ma, Liang Kong
OBJECTIVE: Glioma is the most common and deadly primary malignant tumor in adults. Treatment outcomes are ungratified due to the presence of blood-brain barrier (BBB), glioma stem cells (GSCs) and multidrug resistance (MDR). Docetaxel (DTX) is considered as a potential drug for the treatment of brain tumor, but its effectiveness is limited by its low bioavailability and drug resistance. Tetrandrine (TET) reverses the resistance of tumor cells to chemotherapy drugs. Borneol (BO) modified in micelles has been shown to promote DTX plus TET to cross the BBB, allowing the drug to better act on tumors...
January 18, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38226968/effect-of-stoichiometry-upon-the-characteristics-of-quercetin-arginine-cocrystals-formulated-through-solution-crystallization
#27
JOURNAL ARTICLE
Mahima Mishra, Shivanshu Agrawal, Pratap Bahadur, Sanjay Tiwari
Objective: The aim of this study is to demonstrate the effect of stoichiometry upon characteristics of quercetin-arginine (QCT-Arg) cocrystals. Significance: Quercetin (QCT) is a most abundant flavonoid in vegetables and fruits, and has been widely used as an antioxidant. However, its oral bioavailability remains low due to poor aqueous solubility. We illustrate that QCT-Arg cocrystals formulated through an optimizedstoichiometry can be a useful approach for its solubilization. Method: Cocrystals were prepared using s olvent evaporation method...
January 16, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38194223/integrating-chemical-similarity-and-bioequivalence-an-overall-evaluation-of-the-quality-consistency-of-traditional-decoction-and-dispensing-granule-decoction-of-amomum-villosum
#28
JOURNAL ARTICLE
Yousong Yue, Haiyang Li, Manwen Xu, Lijie Ma, Xiaopeng Wang, Yan Miao, Lu Zhang, Xuelin Li, Ruixin Liu
OBJECTIVE: This study aims to investigate the quality consistency between traditional decoction (TD) of Amomum villosum and its dispensing granule decoction (DGD). Fifteen batches of TD and nine batches of dispensing granules (manufactured by A, B, and C) were prepared and evaluated for their consistency. Methods: Firstly, The chemical similarity of TD and DGD was examined using GC and HPLC, coupled with hierarchical cluster analysis (HCA), criteria importance though intercrieria correlation(CRITIC) weighting method, and principal component analysis (PCA)...
January 9, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38180322/doxorubicin-sanguinarine-nanoparticles-formulation-and-evaluation-of-breast-cancer-cell-apoptosis-and-cell-cycle
#29
JOURNAL ARTICLE
Mahmoud Zaki El-Readi, Majed Abdurhman Abdulkarim, Ahmed A H Abdellatif, Mohamed E Elzubeir, Bassem Refaat, Mohammad Althubiti, Riyad Adnan Almaimani, Mohammed Hasan Mukhtar, Issa Saad Al-Moraya, Safaa Yehia Eid
Background Therapeutic resistance fails cancer treatment. Drug-nanoparticle combinations overcome resistance. Sanguinarine-conjugated nanoparticles may boost sanguinarine's anticancer effects. Methods : Sanguinarine, HPMC-NPs, and doxorubicin were tested on Adriamycin-resistant MCF-7/ADR breast cancer cells, parent-sensitive MCF-7, and MCR-5 normal cells (DX). Results : Regular distribution, 156 nm diameter, <1 μm average size, 100% intensity-SN is therapeutic. Furthermore, the obtained NPs showed PDI = 0...
January 5, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38180038/solvent-free-method-for-masking-the-bitter-taste-of-azithromycin-dihydrate-using-supercritical-fluid-technology
#30
JOURNAL ARTICLE
Hadeia Mashaqbeh, Rana M Obaidat, Mo'tasem M Alsmadi
Introduction and purpose The unpleasant extremely bitter taste of the orally administered broad-spectrum antibiotic azithromycin decreases patient compliance, especially in pediatrics. This issue can be overcome by decreasing drug interaction with the tasting buds using insoluble polymers at salivary pH (6.8 -7.4), like the cationic polymer Eudragit EPO. Supercritical fluid technology is a green synthesis method for preparing pharmaceutical preparations that replace organic solvents with safe supercritical CO2 ...
January 5, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38175566/revisiting-the-significance-of-nano-vitamin-d-for-food-fortification-and-therapeutic-application
#31
REVIEW
Gaurav K Jain, Vidya Raina, Rakshita Grover, Jagriti Sharma, Musarrat Hussain Warsi, Geeta Aggarwal, Prashant Kesharwani
Objective: Vitamin D (a prohormone) is an important micronutrient required by the body for skeletal homeostasis and a range of non-skeletal actions. Calcitriol, the active form of vitamin D, regulates a variety of cellular and metabolic processes through both genomic and nongenomic pathways. Often prescribed for treating rickets and osteoporosis, vitamin D deficiency can exacerbate various other medical conditions. Significance, Methods, Results: Despite its multifunctional uses, the sensitivity of Vitamin D makes formulating an efficient drug delivery system a challenging task, which is further complicated by its poor aqueous solubility...
January 4, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38158799/interdigitation-of-lipids-for-vesosomal-formulation-of-ergotamine-tartrate-with-caffeine-a-futuristic-trend-of-intranasal-route
#32
JOURNAL ARTICLE
Preeti Dali, Pravin Shende
Objective: This research work aimed to form vesosomes using combination of two drugs ergotamine and caffeine for synergistic activity when given intranasally resulting in faster absorption, steric stability and controlled release. Significance: The multicompartment vesicles viz., vesosomes of ergotamine tartrate proved to increase absorption of drugs post-intranasal administration, bypassing the blood-brain barrier via the olfactory pathway Methods: The phospholipids like soya lecithin, cholesterol and dipalmitoyl phosphatidylcholine were used to form a multicompartment structure called vesosomes using ethanol-induced interdigitation of lipids as the preparation method...
December 30, 2023: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38156891/development-of-oral-formulation-of-lepidium-seeds-significantly-decreases-the-high-blood-glucose-levels-in-diabetic-rats-in-vitro-formulation-and-in-vivo-antidiabetic-performance
#33
JOURNAL ARTICLE
Basmah N Aldosari, Ahmed A H Abdellatif, Alanood Sunhat Almurshedi, Iman Mohammed Alfagih, Bushra Tawfeeq AlQuadeib, Asmaa Youssef A Abbas, Yasser A Hassan, Ahmed Abdelfattah, Hesham M Tawfeek
BACKGROUND: Lepidium sativum , Garden Cress (GC), seeds have a lot of natural molecules with a pronounced activity against different disorders. It was reported that GC seeds have the ability to lower the blood glucose level. AIM: The aim of this work was to formulate GC seeds into oral tablets containing a fixed dose of the grounded seeds. Furthermore, the anti-diabetic performance of the prepared tablets was studied in the streptozotocin rats' model in comparison with positive control metformin...
December 29, 2023: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38149637/development-of-a-novel-direct-compressible-co-processed-excipient-and-its-application-for-formulation-of-mirtazapine-orally-disintegrating-tablets
#34
JOURNAL ARTICLE
Ying Hui Loke, Yik-Ling Chew, Ashok Kumar Janakiraman, Siew-Keah Lee, A B M Helal Uddin, Choon Fu Goh, Phei Er Kee, Hui Suan Ng, Long Chiau Ming, Kai Bin Liew
INTRODUCTION: Orally disintegrating tablets (ODTs) are designed to dissolve in the oral cavity within 3 min, providing a convenient option for patients as they can be taken without water. Direct compression is the most common method used for ODTs formulations. However, the availability of single composite excipients with desirable characteristics such as good compressibility, fast disintegration, and a good mouthfeel suitable for direct compression is limited. OBJECTIVE: This research was proposed to develop a co-processed excipient composed of xylitol, mannitol, and microcrystalline cellulose for the formulation of ODTs...
December 27, 2023: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38148515/intranasal-administration-of-innovative-triamcinolone-acetonide-encapsulated-cubosomal-in-situ-gel-formulation-and-characterization
#35
JOURNAL ARTICLE
Ruturaj Patil, Archana S Patil, Krutuja Chougule, Yadishma Gaude, Rajashree S Masareddy
Aim: The primary objective of the research was to develop a cubosomal in situ gel encapsulated with Triamcinolone acetonide (TCA) in order to enhance its penetration through the blood-brain barrier (BBB) when administered via the intranasal route, thus enabling efficient and rapid action. Method: Cubosomes were formulated by top-down approach using glyceryl monooleate (GMO), using pluronics127 (PF127) and polyvinyl alcohol (PVA) in varying proportions based on the Box-Behnken design. High resolution transmission electron microscopy (HR-TEM) analysis confirmed the morphology of the cubosomes...
December 26, 2023: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38145420/enhancing-oral-bioavailability-of-ca-dtpa-by-self-double-emulsifying-drug-delivery-system-sdedds
#36
JOURNAL ARTICLE
Vaishali Agrawal, Anjali Priyadarshani, Dharam Pal Pathak, Nidhi Sandal
OBJECTIVE: BCS classIII drug (highly soluble, poorly permeable) possess low oral bioavailability. The research work highlights the utility of Self double emulsifying drug delivery system (SDEDDS) which are stable isotropic mixture of w/o primary emulsion and hydrophilic surfactants for improving oral bioavailability of Ca-DTPA (Calcium diethylenetriamine pentaacetate). Upon oral administration, SDEDDS rapidly emulsifies into w/o/w double emulsions in the aqueous gastrointestinal environment, with hydrophilic drugs entrapped inside oil reservoirs...
December 25, 2023: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38140860/quantitative-analysis-of-cephalexin-in-solid-dosage-form-by-raman-spectroscopy-and-chemometric-tools
#37
JOURNAL ARTICLE
Nida Ghafoor, Naeema Kanwal, Haq Nawaz, Muhammad Irfan Majeed, Nosheen Rashid, Shazra Ishtiaq, Rabiah Tariq, Kiran Kainat, Arslan Ali, Ayesha Anwar, Zainab Shoukat, Aiman Amir, Muhammad Imran
OBJECTIVE: To use Raman Spectroscopy for qualitative and quantitative evaluation of pharmaceutical formulations of active pharmaceutical ingredient (API) of Cephalexin. SIGNIFICANCE: Raman Spectroscopy is a non-invasive, non-destructive, reliable and rapid detection technique used for various pharmaceutical drugs quantification. The present study explores the potential of Raman Spectroscopy for quantitative analysis of pharmaceutical drugs. METHOD: For qualitative and quantitative analysis of Cephalexin API, various standard samples containing less and more concentration of API than commercial tablet was prepared...
December 23, 2023: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38112520/-in-silico-exploration-of-venlafaxine-a-potential-non-tricyclic-antidepressant-in-a-liposomal-formulation-for-nose-to-brain-drug-delivery
#38
JOURNAL ARTICLE
Sulekha Khute, Rajendra K Jangde
OBJECTIVE: Non-tricyclic antidepressants (non-TCAs) work by preventing the intake of norepinephrine and serotonin. Therefore, the aim of this study was to identify a potent non-TCAs and to develop liposomal formulation, characterize and to determine the drug release study across model of dialysis membrane via in vitro and in silico techniques. METHODS: The in silico docking analysis identified venlafaxine (VLF) as the best non-TCAs with the depressant targets (PDB ID: 3PBL and 4BVN)...
December 19, 2023: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38095592/enhancement-of-dissolution-rate-and-oral-bioavailability-of-poorly-soluble-drug-florfenicol-by-using-solid-dispersion-and-effervescent-disintegration-technology
#39
JOURNAL ARTICLE
Chao Li, Nanxin Li, Xingyu Chen, Xiaojuan Li, Chang Liu, Awn Abbas, Yueli Wang, Shuangcai Qi, Yifan Zhang, Dongbo Li, Wei Zhang, Gang Shu, Juchun Lin, Haohuan Li, Funeng Xu, Guangneng Peng, Hualin Fu
UNLABELLED: Objective Florfenicol(FF) is an excellent veterinary antibiotic, limited by poor solubility and poor bioavailability. SIGNIFICANCE: Here in, we aimed to explore the applicability of fast disintegrating tablets compressed from Florfenicol-loaded solid dispersions (FF-SD-FDTs) to improve the dissolution rate and oral bioavailability of Florfenicol. METHODS: Utilizing selecting appropriate preparation methods and carriers, the solid dispersions of Florfenicol (FF-SDs) were prepared by solvent evaporation and the fast disintegrating tablets (FF-SD-FDTs) were prepared by the direct compression (DC) method...
December 14, 2023: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38087641/preparation-of-piroxicam-nanosuspensions-by-high-pressure-homogenization-and-evaluation-of-improved-bioavailability
#40
JOURNAL ARTICLE
Okan Ali Aksoy, Merve Zanbak Çotaoğlu, Tugba Fatsa, Gizem Ruya Topal, Özgür Eşim, Berk Alp Göksel, Tuğrul Hoşbul, Cansel Köse Özkan, Ayhan Savaşer, Yalçın Özkan
OBJECTIVE: Inflammation is a natural response of the organism, involving events responsible for releasing chemical mediators and requiring treatments of symptoms such as pain, redness, heat, swelling, and loss of tissue function. Piroxicam (PRX) is a non-steroidal anti-inflammatory drug with the effect of nonselective COX inhibitor activity; however, it shows poor bioavailability caused by the poor and slow water solubility. In this study, we developed PRX nanosuspensions with 200-500 nm in diameter to increase the bioavailability of PRX by improving its solubility...
December 12, 2023: Drug Development and Industrial Pharmacy
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