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Drug Development and Industrial Pharmacy

Shaheen Sultana, Sushma Talegaonkar, Bhaskar Ray, Harvinder Singh, F J Ahmad, Gaurav Mittal, Aseem Bhatnagar
INTRODUCTION: In this study, different nifedipine-loaded formulations were prepared to treat pylorospasm, a sphincter muscle disorder characterized by delayed gastric emptying process. The efficacy of formulation was evaluated in patients by subjective assessment, gamma scintigraphic approaches, and confocal microscopy. METHODS: Nifedipine-loaded different formulations such as sucrose bead, pellets, and microparticles (slugging method, ionotropic gelation, and chemical denaturation) were designed...
February 21, 2018: Drug Development and Industrial Pharmacy
Nahid Poorgholy, Bakhshali Massoumi, Marjan Ghorbani, Mehdi Jaymand, Hamed Hamishehkar
This article evaluates the anticancer drug delivery performances of two nanohydrogels composed of poly(N-isopropylacrylamide-co-itaconic anhydride) [P(NIPAAm-co-IA)], poly(ethylene glycol) (PEG), and Fe 3 O 4 nanoparticles. For this purpose, the magnetite nanohydrogels (MNHGs) were loaded with doxorubicin hydrochloride (DOX) as a universal anticancer drug. The morphologies and magnetic properties of the DOX-loaded MNHGs were investigated using transmission electron microscopy (TEM) and vibrating-sample magnetometer (VSM), respectively...
February 16, 2018: Drug Development and Industrial Pharmacy
Mahdieh Farhangi, Farzad Kobarfard, Arash Mahboubi, Alireza Vatanara, Seyed Alireza Mortazavi
OBJECTIVE: The objective of present study was to evaluate the effect of lipid structure on physicochemical properties of chitosan-fatty acid nanomicelles and prepare an optimum ciprofloxacin loaded formulation from these conjugates which could enhance the antibacterial effects of drug against some important pathogens like P. aeroginosa. SIGNIFICANCE: Nowadays, resistance in infectious diseases is a growing worldwide concern. Nanocarriers can increase the therapeutic index and consequently reduce the antibiotic resistance...
February 16, 2018: Drug Development and Industrial Pharmacy
Mohamed F Zidan, Hany M Ibrahim, Mohsen I Afouna, Elsherbeny A Ibrahim
The aim of this study was to explore the feasibility of complexing the poorly water-soluble drug atorvastatin calcium (AC) with β-cyclodextrin (β-CD) based nanosponges (NS), which offer advantages of improving dissolution rate and eventually oral bioavailability. Blank NS were fabricated at first by reacting β-CD with the cross-linker carbonyldiimidazole at different molar ratios (1:2, 1:4 and 1:8), then NS of highest solubilization extent for AC were complexed with AC. AC loaded NS (AC-NS) were characterized for various physicochemical properties...
February 16, 2018: Drug Development and Industrial Pharmacy
Jaleh Varshosaz, Saeede Enteshari, Farshid Hassanzadeh, Batool Hashemi-Beni, Mohsen Minaiyan, Razieh Mirsafaei
OBJECTIVE: the goal of the present work was to make novel co-polymeric micellar carriers for the delivery of docetaxel (DTX). SIGNIFICANCE: Co-polymeric micelles can not only solubilize DTX and eliminate the need for toxic surfactants to dissolve it, but also cause passive targeting of the drug to the tumor and reduce its toxic side effects. METHODS: Poly (styrene-maleic acid) (SMA) was conjugated to poly (amide-ether-ester-imide)-poly ethylene glycol (PAEEI-PEG)...
February 13, 2018: Drug Development and Industrial Pharmacy
Mahesh Thondawada, Ashish Devidas Wadhwani, Dhanabal S Palanisamy, Hanumant Singh Rathore, Ramesh C Gupta, Pavan Kumar Chintamaneni, Malay K Samanta, Anil Dubala, Sameer Varma, Praveen T Krishnamurthy, Kuppusamy Gowthamarajan
Nanotechnology based bio-medical approaches and surface modification techniques made it easier for targeting specific site and improving the treatment efficacy. The present study reports on targeted polymeric nanoparticles conjugated with antibody as a site-specific carrier system for effective treatment of Type 1 diabetes. Sitagliptin (SP) loaded Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NP) were prepared by nanoprecipitation cum solvent evaporation method and were characterized in terms of morphology, size, surface charge and entrapment efficiency...
February 12, 2018: Drug Development and Industrial Pharmacy
Kholoud Arafa, Rehab N Shamma, Omaima N El-Gazayerly, Ibrahim M El-Sherbiny
PURPOSE: Metformin hydrochloride (MF) repurposing as adjuvant anticancer therapy for colorectal cancer (CRC) proved effective. Several studies attempted to develop MF-loaded nanoparticles (NPs), however the entrapment efficiency (EE%) was poor. Thus, the present study aimed at the facile development of a new series of chitosan (CS)-based semi-interpenetrating network (semi-IPN) NPs incorporating Pluronic ® nanomicelles as nanocarriers for enhanced entrapment and sustained release of MF for efficient treatment of CRC...
February 12, 2018: Drug Development and Industrial Pharmacy
Sheetal Chauhan, Monika Bansal, Gayasuddin Khan, Sarita K Yadav, Ashish K Singh, Pradyot Prakash, Brahmeshwar Mishra
OBJECTIVE: Aim of the present study was to prepare curcumin (CUR) loaded biodegradable crosslinked gelatin (GE) film to alleviate the existing shortcomings in the treatment of periodontitis. SIGNIFICANCE: Gelatin film was optimized to provide anticipated mucoadhesive strength, mechanical properties, folding endurance and prolonged drug release over treatment duration, for successful application in the periodontitis. METHODS: The film was developed by using solvent casting technique and "Design of Experiments" approach was employed for evaluating the influence of independent variables on dependent response variables...
February 12, 2018: Drug Development and Industrial Pharmacy
Mahmoud S Soliman, Fathy I Abd-Allah, Talib Hussain, Noha M Saeed, Hossam S El-Sawy
OBJECTIVE: An optimized Date seed oil (DSO) loaded niosomes was formulated. SIGNIFICANCE: Maximize the extract anti-inflammatory efficacy and govern its release characteristics from nanoparticles for osteoarthritis prevention and treatment purposes. METHODS: By using Box-Behnken Design, the effect of 3 formulation factors on the entrapment efficiency percentage (Y1), initial DSO release percentage after 2 h (Y2), and cumulative DSO release percentage of DSO after 12 h (Y3), were optimized and studied...
February 8, 2018: Drug Development and Industrial Pharmacy
Seema Saroj, Sadhana J Rajput
A multifaceted therapeutic platform has been proposed for controlled delivery of Etoposide (ETS) leading to a synergistic advantage of maximum therapeutic efficacy and diminished toxicity. A state of the art pH responsive nanoparticles (NPs) MSNs-PAA consisting of mesoporous silica nanoparticles core and polymeric shell layers, were developed for controlled release of model anti-cancer drug ETS. Graft onto strategy was employed and amination served as an interim step, laying a vital foundation for functionalization of the MSN core with hydrophilic and pH responsive polyacrylic acid (PAA)...
February 7, 2018: Drug Development and Industrial Pharmacy
Zahari Vinarov, G Gancheva, V Katev, S Tcholakova
OBJECTIVE: To reveal the physicochemical mechanisms governing the solubilization of albendazole in surfactant and phospholipid-surfactant solutions and, on this basis, to formulate clinically-relevant dose of albendazole in solution suitable for parenteral delivery. SIGNIFICANCE: (1) A new drug delivery system for parenteral delivery of albendazole is proposed, offering high drug solubility and low toxicity of the materials used; (2) New insights on the role of surface curvature on albendazole solubilization in surfactant and surfactant-phospholipid aggregates are provided...
February 7, 2018: Drug Development and Industrial Pharmacy
Joseph Shailender, Punna Rao Ravi, Reddy Sirukuri Mrinalini, Avantika Dalvi, Odapalli Keerthi Priya
OBJECTIVE: Design Chitosan based nanoparticles for tenofovir disoproxil fumarate (TDF) with the purpose of enhancing its oral absorption. SIGNIFICANCE: TDF is a prodrug that has limited intestinal absorption because of its susceptibility to gut wall esterases. Hence, design of chitosan based polymeric novel nanocarrier systems can protect TDF from getting metabolized and also enhance the oral absorption. METHODS: The nanoparticles were prepared using the ionic gelation technique...
February 7, 2018: Drug Development and Industrial Pharmacy
Gurpreet Kaur Sinhmar, Neel N Shah, Nimitt V Chokshi, Hiren N Khatri, Mayur M Patel
The major challenge involved in the treatment of inflammatory bowel disease is targeted delivery of the drug at the site of inflammation. As nanoparticles possess the ability to accumulate at the site of inflammation, present investigation aims at development of Budesonide-loaded nanostructured lipid carrier systems (BDS-NLCs) for the treatment of inflammatory bowel disease. BDS-NLCs were prepared by employing a high pressure homogenization technique. Various preliminary trials were performed for optimization of the NLCs in which different processes, as well as formulation parameters, were studied...
February 6, 2018: Drug Development and Industrial Pharmacy
Joyline Dsa, Manish Goswami, B R Singh, Nidhi Bhatt, Pankaj K Sharma, Meenakshi Chauhan
We present a novel approach of designing and fabricating a non-invasive drug delivery device which is capable of delivering the drug to the target site in a controlled manner. The device utilizes a reservoir which can be reused once the drug has completely diffused from it. This micro-reservoir based fabricated device has been successfully tested using niosomes of insulin drug filled in, which was then sealed with a magnetic membrane of 20µm thick and was actuated by applying magnetic field. The deflection of the membrane on application of magnetic field results in the drug release from the reservoir...
February 2, 2018: Drug Development and Industrial Pharmacy
Sumera Latif, Nasir Abbas, Amjad Hussain, Muhammad Sohail Arshad, Nadeem Irfan Bukhari, Hafsa Afzal, Sualeha Riffat, Zeeshan Ahmad
Paracetamol, a frequently used antipyretic and analgesic drug, has poor compression moldability owing to its low plasticity. In this study, new co-crystals of paracetamol (PCM) with caffeine (as a co-former) were prepared and delineated. Co-crystals exhibited improved compaction and mechanical behavior. A screening study was performed by utilizing a number of methods namely dry grinding, liquid assisted grinding (LAG), solvent evaporation (SE) and anti-solvent addition using various weight ratios of starting materials...
February 1, 2018: Drug Development and Industrial Pharmacy
Subhash Deshmane, Snehal Deshmane, Santosh Shelke, Kailash Biyani
Ambrisantan is an is an US FDA approved drug, it is the second oral endothelin A-receptor antagonist known for the treatment of pulmonary arterial hypertension, but its oral administration is limited due to its poor water solubility. Hence, the objective of the investigation was focused on enhancement of solubility and bioavalibability of Ambrisantan by solid dispersion technique using natural Daucuscarota extract as drug carrier. Drug carrier was evaluated for solubility, swelling index, viscosity, angle of repose, hydration capacity and Acute Toxicity Test (LD50)...
January 31, 2018: Drug Development and Industrial Pharmacy
Yoshihiro Hayashi, Takuya Oishi, Kaede Shirotori, Yuki Marumo, Atsushi Kosugi, Shungo Kumada, Daijiro Hirai, Kozo Takayama, Yoshinori Onuki
OBJECTIVES: The aim of this study was to explore the potential of boosted tree (BT) to develop a correlation model between active pharmaceutical ingredient (API) characteristics and a tensile strength (TS) of tablets as critical quality attributes. METHODS: First, we evaluated 81 kinds of API characteristics such as particle size distribution, bulk density, tapped density, Hausner ratio, moisture content, elastic recovery, molecular weight, and partition coefficient...
January 29, 2018: Drug Development and Industrial Pharmacy
Fei Xiong, Shengxin Huang, Ning Gu
Nanostructured functional materials have demonstrated their great potentials in medical applications, attracting increasing attention because of the opportunities in cancer therapy and the treatment of other ailments. This article reviews the problems and recent advances in the development of magnetic NPs for drug delivery.
January 25, 2018: Drug Development and Industrial Pharmacy
Sarvi Yadav Rajesh, Sachin Kumar Singh, Narendra Kumar Pandey, Parth Sharma, Palak Bawa, Bimlesh Kumar, Monica Gulati, Subheet Jain, K Gowthamarajan, Saurabh Singh
Development of self-nanoemulsifying drug delivery systems (SNEDDS) of glimepiride is reported with the aim to achieve its oral delivery. Lauroglycol FCC, tween-80, and ethanol were used as oil, surfactant and co-surfactant, respectively as independent variables. The optimized composition of SNEDDS formulation (F1) was 10% v/v Lauroglycol FCC, 45% v/v Tween 80, 45%v/v ethanol, and 0.005% w/v glimepiride. Further, the optimized liquid SNEDDS were solidified through spray drying using various hydrophilic and hydrophobic carriers...
January 23, 2018: Drug Development and Industrial Pharmacy
Peng Yang, Ying Li, Wanqing Li, Hui Zhang, Jing Gao, Jianxu Sun, Xiaoxing Yin, Aiping Zheng
Carfentanil (CFTN), a derivative of fentanyl, is highly effective as an analgesic, but its relatively poor solubility in water has limited its nasal application. The objective of this study was to develop the new CFTN-CD inclusion technology to increase the solubility of CFTN. The inclusion compound CFTN-DM-β-CD was prepared by the ultrasonic method and characterized using x-ray powder diffraction and morphological shapes analysis (the scanning electron microscopy). The in vitro dissolution profiles of CFTN-DM-β-CD were assessed in hydrochloric acid and phosphate buffer...
January 23, 2018: Drug Development and Industrial Pharmacy
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