Zishan Ke, Jing Wen, Yingying Wang, Bo Li, Siyu Wu, Defeng Zhang, Xubing Mo, Yingying Li, Yan Ren, Jiyuan Yin, Cunbin Shi, Shucheng Zheng, Qing Wang
Tilapia lake virus (TiLV) is an emerging virus that seriously threatens the tilapia industries worldwide. Interferon regulatory factors (IRFs), which are the crucial mediators regulating the response of interferon (IFN) to combat invading viruses, have not yet been reported in tilapia during TiLV infection. Here, six IRF (IRF1, IRF2, IRF4, IRF7, IRF8, and IRF9) homologs from tilapia were characterized and analyzed. These IRFs typically shared the conserved domains and phylogenetic relationship with IRF homologs of other species...
February 24, 2024: Developmental and Comparative Immunology