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Developmental and Comparative Immunology

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https://www.readbyqxmd.com/read/29792901/identification-and-functional-characterization-including-cytokine-production-modulation-of-the-novel-chicken-interleukin-11
#1
Anh Duc Truong, Yeojin Hong, Deivendran Rengaraj, Janggeun Lee, Kyungbaek Lee, Yeong Ho Hong
Interleukin (IL)-11 plays an important role in the immune system. However, IL-11 has not yet been characterized in avian species, including chickens. This study is the first to clone and functionally characterize chicken IL-11 (chIL-11). Multiple alignments and phylogenetic tree comparisons of chIL-11 with IL-11 proteins from other species revealed high levels of conservation and a close relationship between chicken and Japanese quail IL-11. Our results demonstrate that chIL-11 was a functional ligand of IL-11RA and IL-6ST in chicken HD11 and OU2 cell lines, as well as activated and regulated JAK-STAT, NF-κB, PI3K/AKT, and MAPK signaling pathways in chicken cell lines...
May 21, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29787778/monoclonal-antibodies-against-loggerhead-sea-turtle-caretta-caretta-igy-isoforms-reveal-differential-contributions-to-antibody-titers-and-relatedness-among-other-sea-turtles
#2
Maria L Rodgers, Charles D Rice
Serum from loggerhead sea turtles, Caretta caretta, was collected from the southeast Atlantic Ocean during routine summer monitoring studies in 2017. Serum immunoglobulin IgY was purified and used to develop IgY isoform-specific monoclonal antibodies (mAb). mAb LH12 was developed against the 66 kDa heavy chain of IgY, mAb LH1 was developed against the truncated heavy chain of approximately 37 kDA, and mAb LH9 was developed against the 23 kDa light chains. mAb LH9 reacts with the light chains of all sea turtles, mAb LH12 reacts with the long heavy chain of all sea turtles within the family Cheloniidae, and mAb LH1 reacts with the truncated form of IgY in both olive and Kemp's ridley turtles...
May 19, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29777721/pentraxins-crp-i-and-crp-ii-are-post-translationally-deiminated-and-differ-in-tissue-specificity-in-cod-gadus-morhua-l-ontogeny
#3
Bergljót Magnadóttir, Polly Hayes, Berglind Gísladóttir, Birkir Þór Bragason, Mariya Hristova, Anthony P Nicholas, Sigríður Guðmundsdóttir, Sigrun Lange
Pentraxins are fluid phase pattern recognition molecules that form an important part of the innate immune defence and are conserved between fish and human. In Atlantic cod (Gadus morhua L.), two pentraxin-like proteins have been described, CRP-I and CRP-II. Here we show for the first time that these two CRP forms are post-translationally deiminated (an irreversible conversion of arginine to citrulline) and differ with respect to tissue specific localisation in cod ontogeny from 3 to 84 days post hatching. While both forms are expressed in liver, albeit at temporally differing levels, CRP-I shows a strong association with nervous tissue while CRP-II is strongly associated to mucosal tissues of gut and skin...
May 16, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29758230/vaccination-with-uv-inactivated-nodavirus-partly-protects-european-sea-bass-against-infection-while-inducing-few-changes-in-immunity
#4
Yulema Valero, Mokrani Djamal, Elena Chaves-Pozo, Marta Arizcun, Mustapha Oumouna, José Meseguer, M Ángeles Esteban, Alberto Cuesta
Developing viral vaccines through the ultraviolet (UV) inactivation of virus is promising technique since it is straightforward and economically affordable, while the resulting viruses are capable of eliciting an adequate antiviral immune response. Nodavirus (NNV) is a devastating virus that mainly affects European sea bass juveniles and larvae, causing serious economic losses in Mediterranean aquaculture. In this work, a potential vaccine consisting on UV-inactivated NNV (iNNV) was generated and administered to healthy juveniles of European sea bass to elucidate whether it triggers the immune response and improves their survival upon challenge...
May 11, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29753770/molecular-characterization-and-expression-analysis-of-tlr1-and-tlr4-from-the-endangered-fish-dabry-s-sturgeon-acipenser-dabryanus
#5
Panpan Han, Sisi Wang, Qihuan Zhang, Shuhuan Zhang, Rong Shao, Wei Xu, Wenbing Zhang, Qiaoqing Xu, Qiwei Wei, Zhitao Qi
Toll-like receptors (TLRs) are important pattern recognition receptors (PRRs) of teleost innate immune system. However, information about TLRs is absent in Dabry's sturgeon (Acipenser dabryanus), one of the most primitive actinopterygii species. In the present study, the full lengths of adaTLR1 and adaTLR4 were cloned from Dabry's sturgeon using RT-PCR and RACE-PCR. The obtained adaTLR1 was 2957 bp in length, encoding a putative protein of 767 amino acids and adaTLR4 cDNA was 2902 bp in length, encoding a putative protein of 830 aa...
May 10, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29753769/fish-samhd1-performs-as-an-activator-for-ifn-expression
#6
Meifeng Li, Xiaowen Xu, Zeyin Jiang, Changxin Liu, Xiao Shi, Guoqin Qi, Yinping Li, Xin Chen, Qingli Huang, Huiling Mao, Chengyu Hu
As a host limiting factor, Sterile Alpha Motif and Histidine-Aspartate Domain 1 protein (SAMHD1) is associated with IRF3-mediated antiviral and apoptotic responses in mammals. However, the antiviral mechanism of SAMHD1 remains indistinct in fish. In this study, we found the expression of Ctenopharyngodon idella SAMHD1 (MF326081) was up-regulated after transfection with poly I:C (dsRNA analog), B-DNA or Z-DNA into C. idella kidney cells (CIKs), but these expression profiles had no obvious change when the cells were incubated with these nucleic acids...
May 10, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29793044/isolation-of-ferritin-and-its-interaction-with-bmnpv-in-the-silkworm-bombyx-mori
#7
Dong-Qiong Fei, Hai-Zhong Yu, Jia-Ping Xu, Shang-Zhi Zhang, Jie Wang, Bing Li, Li-Ang Yang, Pei Hu, Xin Xu, Kang Zhao, Toufeeq Shahzad
Ferritin is a ubiquitous iron storage protein that plays an important role in host defence against pathogen infections. In the present study, native ferritin was isolated from the hemolymph of Bombyx mori using native-polyacrylamide gel electrophoresis (native-PAGE) and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The results revealed that ferritin consisted of two subunits, designated as BmFerHCH and BmFerLCH. Previously integrated previous transcriptome and iTRAQ data showed that the two subunits were down-regulated in resistant silkworm strain BC9 and there was no obvious change in the expression levels of the subunits in susceptible silkworm strain P50 after BmNPV infection...
May 9, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29751011/differential-innate-immune-responses-induced-by-classical-and-variant-infectious-bronchitis-viruses-in-specific-pathogen-free-chicks
#8
Rajesh Chhabra, Christopher Ball, Julian Chantrey, Kannan Ganapathy
Avian infectious bronchitis virus (IBV) continues to cause serious economic losses in global chicken production. Concurrent circulation of both classic and variant IBVs have been identified in most parts of the world, raising major challenges to global prevention and control efforts. Therefore, immunopathogenesis, particularly early host responses, needs to be better understood for effective control of diseases caused by different strains of IBVs. We investigated differing immunopathogenesis in chickens following infection with IS/885/00-like (885), QX-like (QX) and M41 IBV strains...
May 8, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29751010/siglecs-a-journey-through-the-evolution-of-sialic-acid-binding-immunoglobulin-type-lectins
#9
REVIEW
Kim F Bornhöfft, Tom Goldammer, Alexander Rebl, Sebastian P Galuska
Siglecs (sialic acid-binding immunoglobulin-type lectins) are a family of immune regulatory receptors predominantly found on the cells of the hematopoietic system. A V-set Ig-like domain mediates the recognition of different sialylated glycoconjugates, which can lead to the activation or inhibition of the immune response, depending on the involved Siglecs. Siglecs are categorized into two subgroups: one including all CD33-related Siglecs and the other consisting of Siglec-1 (Sialoadhesin), Siglec-2 (CD22), Siglec-4 (myelin-associated glycoprotein, MAG) and Siglec-15...
May 8, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29746983/microrna-375-modulates-the-nf-%C3%AE%C2%BAb-pathway-in-miiuy-croaker-by-targeting-dusp1-gene
#10
Yuena Sun, Qing Chu, Xueyan Zhao, Zhenzhen Zhou, Dekun Bi, Tianjun Xu
microRNAs (miRNAs) are highly conserved, small non-coding endogenous molecule, and can participate in a variety of biological processes in organisms such as development, growth and immune response. Dual-Specificity Phosphatases (DUSPs) are enzymes that can remove phosphate groups from phosphatases. Research found that DUSP1 is an important molecule in the process of MAPK regulation. However, as a significant regulatory factor, the study of DUSP1 was very few in fish. Consequently, in this study, the regulatory role of miRNAs on DUSP1 has been verified through dual-luciferase reporter assay and western blotting analysis...
May 7, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29746982/comparative-study-of-the-adjuvant-potential-of-four-th0-cytokines-of-flounder-paralichthys-olivaceus-on-an-e-tarda-subunit-vaccine
#11
Ming Guo, Xiaoqian Tang, Xiuzhen Sheng, Jing Xing, Wenbin Zhan
Cytokines have the potential as adjuvants for the application of vaccines in mammals. However, the adjuvant potential of teleost cytokines was limited. In the present work, the adjuvant effects of four recombinant cytokines including IL-1β, IL-8, TNF-α and G-CSF on E. tarda subunit vaccine rOmpV were comparatively investigated in flounder (Paralichthys olivaceus). Compared with control, the levels of specific serum antibodies and IgM + B lymphocytes were significantly enhanced by rIL-1β, rIL-8 and rG-CSF, whereas rIL-1β and rIL-8 induced significantly higher levels than rG-CSF...
May 7, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29746981/characterization-of-a-toll-like-receptor-tlr-signaling-pathway-in-biomphalaria-glabrata-and-its-potential-regulation-by-nf-kappab
#12
Judith E Humphries, Laura E Deneckere
No abstract text is available yet for this article.
May 7, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29746980/in-silico-analysis-of-schmidtea-mediterranea-tir-domain-containing-proteins
#13
Landry Laure Tsoumtsa, Seynabou Sougoufoura, Cedric Torre, Emmanuel Lemichez, Pierre Pontarotti, Eric Ghigo
While genetic evidence points towards an absence of Toll-Like Receptors (TLRs) in Platyhelminthes, the Toll/IL-1 Receptor (TIR)-domains that drive the assembly of signalling complexes downstream TLR are present in these organisms. Here, we undertook the characterisation of the repertoire of TIR-domain containing proteins in Schmidtea mediterranea in order to gain valuable information on TLR evolution in metazoan. We report the presence of twenty proteins containing between one and two TIR domains. In addition, our phylogenetic-based reconstruction approach identified Smed-SARM and Smed-MyD88 as conserved TLR adaptors...
May 7, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29738808/a-hypervariable-immunoglobulin-superfamily-member-from-crassostrea-gigas-functions-as-pattern-recognition-receptor-with-opsonic-activity
#14
Dongyang Liu, Qilin Yi, Yichen Wu, Guangxia Lu, Changhao Gong, Xiaorui Song, Jiejie Sun, Chen Qu, Conghui Liu, Lingling Wang, Linsheng Song
Immunoglobulin superfamily (IgSF), an extensive collection of proteins possessing at least one immunoglobulin-like (Ig-like) domain, performs a wide range of functions in recognition, binding or adhesion process of cells. In the present study, a cysteine-rich motif associated immunoglobulin domain containing protein (designated CgCAICP-1) was identified in Pacific oyster Crassostrea gigas. The deduced protein sequence of CgCAICP-1 contained 534 amino acid residues, with three Ig domains which were designated as IG1, IG2 and IG3, and a cysteine-rich motif between the first and second Ig domain...
May 5, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29778989/involvement-of-serotonin-in-crayfish-hematopoiesis
#15
Chadanat Noonin
Serotonin (5-HT) is a conserved monoamine neurotransmitter that has several physiological functions both in vertebrates and invertebrates. In addition to its well-known function in the central nervous system, 5-HT also participates in peripheral system. However, in crustaceans, the knowledge about peripheral functions of 5-HT is limited. In this study, a role of 5-HT in hematopoiesis in crayfish, Pacifastacus leniusculus, was investigated. The presence of 5-HT in crayfish plasma and the effect of 5-HT injection on hemocyte number were examined...
May 4, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29753984/a-novel-white-spot-syndrome-virus-protein-wssv164-controls-prophenoloxidases-pmpropos-in-shrimp-melanization-cascade
#16
Pakkakul Sangsuriya, Walaiporn Charoensapsri, Jantiwan Sutthangkul, Saengchan Senapin, Ikuo Hirono, Anchalee Tassanakajon, Piti Amparyup
Melanization, mediated by the prophenoloxidase (proPO)-activating system, is an important innate immune response in invertebrates. The implication of the proPO system in antiviral response and the suppression of host proPO activation by the viral protein have previously been demonstrated in shrimp. However, the molecular mechanism of viral-host interactions in the proPO cascade remains largely unexplored. Here, we characterized the viral protein, namely, WSSV164, which was initially identified from the forward suppression subtractive hybridization (SSH) cDNA library of the PmproPO1/2 co-silenced black tiger shrimp Penaeus monodon that was challenged with white spot syndrome virus (WSSV)...
May 4, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29733880/identification-of-a-novel-antimicrobial-peptide-from-the-sea-star-patiria-pectinifera
#17
Chan-Hee Kim, Hey-Jin Go, Hye Young Oh, Ji Been Park, Tae Kwan Lee, Jung-Kil Seo, Maurice R Elphick, Nam Gyu Park
Antimicrobial peptides (AMPs) are components of innate immunity found in many forms of life. However, there have been no reports of AMPs in sea star (Phylum Echinodermata). Here we report the isolation and characterization of a novel antimicrobial peptide from a coelomic epithelium extract of the sea star Patiria pectinifera. The isolated peptide comprises 38 amino acid residues, is cationic (pI 9.2), has four cysteine residues that form two disulfide bonds (C1-C3 and C2-C4) and is amidated at the C-terminus and is designated P...
May 4, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29729283/the-role-of-type-i-interferons-ifns-in-the-regulation-of-chicken-macrophage-inflammatory-response-to-bacterial-challenge
#18
Damien Garrido, Andreas Alber, Emmanuel Kut, Nathalie K Chanteloup, Adrien Lion, Angélina Trotereau, Joëlle Dupont, Karsten Tedin, Bernd Kaspers, Lonneke Vervelde, Sascha Trapp, Catherine Schouler, Rodrigo Guabiraba
Mammalian type I interferons (IFNα/β) are known to modulate inflammatory processes in addition to their antiviral properties. Indeed, virus-induced type I interferons regulate the mammalian phagocyte immune response to bacteria during superinfections. However, it remains unresolved whether type I IFNs similarly impact the chicken macrophage immune response. We first evidenced that IFNα and IFNβ act differently in terms of gene expression stimulation and activation of intracellular signaling pathways in chicken macrophages...
May 2, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29727627/differential-interferon-system-gene-expression-profiles-in-susceptible-and-resistant-gynogenetic-clones-of-gibel-carp-challenged-with-herpesvirus-cahv
#19
Cheng-Yan Mou, Yang Wang, Qi-Ya Zhang, Fan-Xiang Gao, Zhi Li, Jin-Feng Tong, Li Zhou, Jian-Fang Gui
Interferon (IFN) system plays a vital role in the first line of defense against viruses. In this study, we first identified multiple transcripts of 15 IFN system genes, including PRRs (TLR2, TLR3, RIG-I, and LGP2), PRR-mediated IFN signal pathway (MyD88, MITA, and MAVS), IFN regulatory factors (IRF1, IRF3, IRF7, and IRF9), IFNs (IFNφ1 and IFNφ3), and ISGs (Mx and viperin), and one transcript of TLR9 in de novo transcriptome assembly data of gibel carp head-kidney. Multiple nucleotide alignments and phylogenetic analysis of common region showed that the transcripts of every of the 15 IFN system genes were classified into two homologs with distinctly divergent sequences, indicating that hexaploid gibel carp may be an allopolyploid...
May 1, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29747070/salmon-louse-rhabdoviruses-impact-on-louse-development-and-transcription-of-selected-atlantic-salmon-immune-genes
#20
Aina-Cathrine Øvergård, Lars Are Hamre, Sindre Grotmol, Frank Nilsen
Recently, it has been shown that the salmon louse (Lepeophtheirus salmonis) is commonly infected by one or two vertically transmitted Lepeophtheirus salmonis rhabdoviruses (LsRVs). As shown in the present study, the viruses have limited effect on louse survival, developmental rate and fecundity. Since the LsRVs were confirmed to be present in the louse salivary glands, the salmon cutaneous immune response towards LsRV positive and negative lice was analyzed. In general, L. salmonis increased the expression of IL1β, IL8 and IL4/13A at the attachment site, in addition to the non-specific cytotoxic cell receptor protein 1 (NCCRP-1)...
April 30, 2018: Developmental and Comparative Immunology
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