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Alcoholism, Clinical and Experimental Research

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https://www.readbyqxmd.com/read/28543031/in-memoriam-professor-jean-pierre-von-wartburg-1931-2017
#1
Helmut K Seitz
On April 11, 2017, Professor Jean Pierre von Wartburg passed away in his home in Bollingen, near Bern, Switzerland. In addition to being one of the pioneers in alcohol research, he was one of the leading scientists in the field of enzymology and alcohol metabolism. Between 1965 and 1990, he was a giant who dominated the field. This article is protected by copyright. All rights reserved.
May 25, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28543099/evidence-of-altered-mitochondrial-protein-expression-after-chronic-ethanol-consumption-in-the-aged-estrogen-deficient-female-rat-heart
#2
Alexandra M Garvin, J L Miller-Lee, D R Sharda, G M Kanski, J C Hunter, Donna H Korzick
BACKGROUND: Estrogen loss has been implicated to increase the risk of alcoholic cardiomyopathy in post-menopausal women. The purpose of this study was to identify novel mitochondrial protein targets for the treatment of alcoholic cardiomyopathy in aged women using a state-of-the-art proteomics approach. We hypothesized that chronic ethanol (EtOH) ingestion exacerbates maladaptive mitochondrial protein expression in the aged female heart METHODS: Adult (3 mo) and aged (18 mo) F344 ovary-intact or ovariectomized (OVX) rats were randomly assigned an EtOH or control Lieber-DeCarli 'all liquid' diet for 20 wks...
May 19, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28494516/the-modulation-of-the-startle-reflex-as-predictor-of-alcohol-use-disorders-in-a-sample-of-heavy-drinkers-a-4-year-follow-up-study
#3
Rosa Jurado-Barba, Almudena Duque, José Ramón López-Trabada, Isabel Martínez-Gras, María Salud García-Gutiérrez, Francisco Navarrete, Francisco López-Muñoz, Miguel Ángel Jiménez-Arriero, Cesar Ávila, Jorge Manzanares, Gabriel Rubio
BACKGROUND: Previous studies demonstrated that patients with alcohol use disorders (AUDs) show altered startle reflex responses to alcohol-related stimuli. However, there is little information about the role of these altered responses in the development of AUDs. This study examined the startle reflex response to different visual stimuli and the role of these patterns in the development of AUDs in a 4-year follow-up. METHODS: Two hundred and thirty-nine (nondependent) heavy-drinking participants were selected...
May 11, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28493623/aripiprazole-suppression-of-drinking-in-a-clinical-laboratory-paradigm-influence-of-impulsivity-and-self-control
#4
Raymond F Anton, Joseph P Schacht, Konstantin E Voronin, Patrick K Randall
BACKGROUND: Aspects of impulsivity have been implicated in the development, or maintenance, of Alcohol Use Disorder (AUD). The brain dopamine system is implicated in both reward processing/memory (typically subcortical) and in brain inhibitory control mechanisms (typically cortical). Using a validated clinical lab paradigm, the dopamine/serotonin "stabilizing" drug, aripiprazole was evaluated in non-treatment-seeking AUD individuals based on their level of impulsivity/ self-control. METHODS: Ninety-nine individuals (77% male; mean age 27; 7...
May 11, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28493563/nalmefene-prevents-alcohol-induced-neuroinflammation-and-alcohol-drinking-preference-in-adolescent-female-mice-role-of-tlr4
#5
Jorge Montesinos, Anabel Gil, Consuelo Guerri
BACKGROUND: We previously showed that, by activating innate immune receptors toll-like 4 (TLR4), adolescent intermittent ethanol exposure causes neuroinflammation, myelin damage and behavioral dysfunctions. Recent findings reveal that clinically-used opioid antagonists naltrexone (NT) and naloxone (NX) inhibit opioid-induced TLR4 signaling, and that NT, NX and nalmefene (NF), the 6-methylene derivative of NX, are able to reduce alcohol drinking escalation. METHODS: NF (0...
May 11, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28493556/association-of-anticipated-and-laboratory-derived-alcohol-stimulation-sedation-and-reward
#6
Daniel J Fridberg, Sandra Y Rueger, Patrick B S Smith, Andrea C King
BACKGROUND: Laboratory alcohol challenges are the "gold standard" for obtaining accurate measurements of subjective alcohol stimulation, sedation, and reward. However, these approaches are time- and resource-intensive. The present study examined the extent to which self-reported anticipated alcohol stimulation, sedation, and reward corresponded with those same responses measured with the Biphasic Alcohol Effects Scale (BAES), Brief-BAES (B-BAES), and Drug Effects Questionnaire (DEQ) during a controlled laboratory alcohol challenge...
May 11, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28485899/determinants-of-bdnf-blood-levels-in-patients-with-alcohol-use-disorder
#7
Philippe Nubukpo, Nicolas Ramoz, Murielle Girard, Dominique Malauzat, Philip Gorwood
BACKGROUND: Blood Brain Derived Neurotrophic Factor (BDNF) levels are influenced by both addiction and mood disorders, as well as somatic conditions, gender, and genetic polymorphisms, leading to widely varying results. Depressive symptoms and episodes are frequently observed in patients with alcohol-use disorder, and vary widely over time, making it a challenge to determine which aspects are specifically involved in variations of serum BDNF levels in this population. METHODS: We assessed 227 patients with alcohol dependence involved in a detoxification program, at baseline and after a follow-up of six months, for the AUDIT score, the length of alcohol dependence, and the number of past detoxification programs...
May 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28471508/fda-and-ema-need-homology-on-alcohol-outcome-measures-semper-simplicitas-est-purius-modum
#8
LETTER
Bankole A Johnson
Litten et al. (2017) continue to propose important points, which also emanated from my initial commentary (Johnson, 2017) on the paper by Witkiewitz et al. (2017), which call for: a) homology between the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) criteria to be used for determining efficacy in pharmacotherapy trials for alcohol use disorder (AUD); b) measures that have clinical relevance with respect to the health-related consequences of AUD; and c) the establishment that such measures be sensitive enough to detect clinically significant change in pharmacotherapy trials for AUD...
May 4, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28471501/letter-to-editor-in-response-to-johnson-s-commentary-2017-on-the-witkiewitz-and-colleagues-2017-article
#9
LETTER
Raye Z Litten, Daniel E Falk, Stephanie S O'Malley, Katie A Witkiewitz, Karl F Mann, Raymond F Anton
No abstract text is available yet for this article.
May 4, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28470666/alcohol-use-disorders-and-immigration-up-to-the-third-generation-in-france-findings-from-a-39-617-subject-survey-in-the-general-population
#10
Benjamin Rolland, Pierre-Alexis Geoffroy, Baptiste Pignon, Imane Benradia, Hélène Font, Jean-Luc Roelandt, Ali Amad
BACKGROUND: In the United States, first-generation immigrants (FGIs) show lower prevalence rates of alcohol use disorders (AUDs) than the native population, although they experience more psychosocial risk factors. This epidemiological phenomenon is called an "immigrant paradox." No previous study has investigated whether immigrants also exhibit a reduced risk of AUDs in Europe. In a study of the general population in France, we have assessed the adjusted risk of AUDs between nonimmigrants and FGIs, second-generation immigrants (SGIs), and third-generation immigrants (TGIs)...
May 2, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28449374/genetic-variability-in-adenosine-deaminase-like-contributes-to-variation-in-alcohol-preference-in-mice
#11
Heidi M B Lesscher, Alexis Bailey, Louk J M J Vanderschuren
BACKGROUND: A substantial part of the risk for alcohol use disorder (AUD) is determined by genetic factors. We previously used chromosome substitution (CSS) mice, to identify a QTL for alcohol preference on mouse chromosome 2. The aim of this study was to identify candidate genes within this QTL that confer the risk for alcohol preference. METHODS: In order to delineate the neurobiological underpinnings of alcohol consumption, we expanded on the QTL approach to identify candidate genes for high alcohol preference in mice...
April 27, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28440866/a-prospective-comparison-of-how-the-level-of-response-to-alcohol-and-impulsivity-relate-to-future-dsm-iv-alcohol-problems-in-the-coga-youth-panel
#12
Marc A Schuckit, Tom L Smith, George Danko, Robert Anthenelli, Lara Schoen, Mari Kawamura, John Kramer, Danielle M Dick, Zoe Neale, Samuel Kuperman, Vivia McCutcheon, Andrey P Anokhin, Victor Hesselbrock, Michie Hesselbrock, Kathleen Bucholz
BACKGROUND: Alcohol problems reflect both environmental and genetic characteristics that often operate through endophenotypes like low levels of response (low LRs) to alcohol and higher impulsivity. Relationships of these preexisting characteristics to alcohol problems have been studied, but few analyses have included both low LR and impulsivity in the same model. METHODS: We extracted prospective data from 1,028 participants in the Prospective Youth Sample of the Collaborative Study on the Genetics of Alcoholism (COGA)...
April 25, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28440861/findings-from-the-families-on-track-intervention-pilot-trial-for-children-with-fetal-alcohol-spectrum-disorders-and-their-families
#13
Christie L M Petrenko, Mary E Pandolfino, Luther K Robinson
BACKGROUND: Individuals with fetal alcohol spectrum disorders (FASD) are at high risk for costly, debilitating mental health problems and secondary conditions, such as school disruption, trouble with the law, and substance use. The study objective was to pilot a multi-component intervention designed to prevent secondary conditions in children with FASD and improve family adaptation. METHODS: Thirty children with FASD or prenatal alcohol exposure (PAE) (ages 4 to 8) and their primary caregivers were enrolled...
April 25, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28425123/a-5-year-follow-up-of-a-cohort-of-italian-alcoholics-hospital-admissions-and-overall-survival
#14
Gabriele Bardazzi, Ines Zanna, Marco Ceroti, Benedetta Bendinelli, Adriana Iozzi, Saverio Caini, Gabriella Nesi, Calogero Saieva
BACKGROUND: Alcohol-use disorders (AUDs), including alcohol dependence and alcohol abuse defined according to specific DSM-IV and ICD-X criteria, can be potentially lethal, since they are associated with several medical and psychiatric conditions. This study aims to describe the causes of hospitalization of a large cohort of subjects with alcohol dependence (alcoholics) enrolled in Florence (Italy) over a 5-year follow-up period and to evaluate the effect of hospitalization on overall survival...
April 20, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28425121/role-of-the-dynorphin-kappa-opioid-receptor-system-in-the-motivational-effects-of-ethanol
#15
Rachel I Anderson, Howard C Becker
Evidence has demonstrated that dynorphin (DYN) and the kappa opioid receptor (KOR) system contribute to various psychiatric disorders, including anxiety, depression, and addiction. More recently, this endogenous opioid system has received increased attention as a potential therapeutic target for treating alcohol use disorders. In this review, we provide an overview and synthesis of preclinical studies examining the influence of alcohol (ethanol) exposure on DYN/KOR expression and function, as well as studies examining the effects of DYN/KOR manipulation on ethanol's rewarding and aversive properties...
April 20, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28425109/alcoholic-cardiomyopathy-disrupted-protein-balance-and-impaired-cardiomyocyte-contractility
#16
Jennifer L Steiner, Charles H Lang
Alcoholic cardiomyopathy (ACM) can develop after consumption of relatively large amounts of alcohol over time or from acute binge drinking. Of the many factors implicated in the etiology of ACM, chronic perturbation in protein balance has been strongly implicated. This review focuses on recent contributions (since 2010) in the area of protein metabolism and cardiac function related to ACM. Data reviewed include that from in vitro and preclinical in vivo animal studies where alcohol or an oxidative metabolite was studied and outcome measures in either cardiomyocytes or whole heart pertaining to protein synthesis or degradation were reported...
April 20, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28423479/does-a-crossover-age-effect-exist-for-african-american-and-hispanic-binge-drinkers-findings-from-the-2010-to-2013-national-study-on-drug-use-and-health
#17
Tamika C B Zapolski, Patrick Baldwin, Devin E Banks, Timothy E Stump
BACKGROUND: Among general population studies, lower rates of binge drinking tend to be found among African Americans and Hispanics compared to Whites. However, among older adult populations, minority groups have been shown to be at higher risk for binge drinking, suggesting the presence of a crossover effect from low to high risk as a function of age. To date, limited research has examined the crossover effect among African American and Hispanic populations compared to non-Hispanic Whites across large developmental time frames or explored variation in risk based on income or gender...
April 19, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28423476/dietary-patterns-and-alcohol-consumption-during-pregnancy-secondary-analysis-of-avon-longitudinal-study-of-parents-and-children
#18
Victoria Coathup, Kate Northstone, Ron Gray, Simon Wheeler, Lesley Smith
BACKGROUND: Large general population surveys show that heavy regular and episodic alcohol consumption are associated with lower intakes of fruits and vegetables, and higher intakes of processed and fried meat. This is of particular concern regarding pregnant women, as both alcohol intake and inadequate maternal nutrition are independently associated with adverse fetal outcomes. The current study aimed to determine associations between maternal dietary patterns and alcohol consumption during pregnancy...
April 19, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28421623/a-preliminary-investigation-of-the-effect-of-acute-alcohol-on-dopamine-transmission-as-assessed-by-11-c-phno
#19
Thulasi Thiruchselvam, Alan A Wilson, Isabelle Boileau, Bernard Le Foll
BACKGROUND: Previous positron emission tomography (PET) studies exploring the effect of acute alcohol on dopamine (DA) levels have yielded inconsistent results, with only some studies suggesting increased synaptic DA levels after an alcohol challenge. The D2 /D3 agonist radiotracer, [(11) C]-(+)-propyl-hexahydro-naphtho-oxazin ([(11) C]-(+)-PHNO), has greater sensitivity to synaptic DA fluctuation than previously used antagonist radiotracers and is in principle more suitable for imaging alcohol-induced changes in DA...
April 19, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28421617/eveningness-and-later-sleep-timing-are-associated-with-greater-risk-for-alcohol-and-marijuana-use-in-adolescence-initial-findings-from-the-ncanda-study
#20
Brant P Hasler, Peter L Franzen, Massimiliano de Zambotti, Devin Prouty, Sandra A Brown, Susan F Tapert, Adolf Pfefferbaum, Kilian M Pohl, Edith V Sullivan, Michael D De Bellis, Bonnie J Nagel, Fiona C Baker, Ian M Colrain, Duncan B Clark
BACKGROUND: Abundant cross-sectional evidence links eveningness (a preference for later sleep-wake timing) and increased alcohol and drug use among adolescents and young adults. However, longitudinal studies are needed to examine whether eveningness is a risk factor for subsequent alcohol and drug use, particularly during adolescence, which is marked by parallel peaks in eveningness and risk for the onset of alcohol use disorders. The present study examined whether eveningness and other sleep characteristics were associated with concurrent or subsequent substance involvement in a longitudinal study of adolescents...
April 19, 2017: Alcoholism, Clinical and Experimental Research
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