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Alcoholism, Clinical and Experimental Research

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https://www.readbyqxmd.com/read/27901267/binge-alcohol-intake-after-hypergravity-stress-sustainably-decreases-ampk-and-transcription-factors-necessary-for-hepatocyte-survival
#1
Sang Gil Lee, Hong Min Wu, Chan Gyu Lee, Choong Sik Oh, So Won Chung, Sang Geon Kim
BACKGROUND: Binge alcohol consumption elicits mitochondrial dysfunction in hepatocytes. An understanding of the effect of ethanol (EtOH) exposure after hypergravity stress on liver function may assist in the implementation of pathophysiological countermeasures for aerospace missions. This study investigated whether a combination of hypergravity stress and binge alcohol intake has a detrimental effect on AMP-activated protein kinase (AMPK) and other molecules necessary for hepatocyte survival...
November 30, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27892595/the-rate-of-change-in-alcohol-misuse-across-adolescence-is-heritable
#2
Alexis C Edwards, Jon Heron, Vladimir Vladimirov, Aaron R Wolen, Daniel E Adkins, Fazil Aliev, Matthew Hickman, Kenneth S Kendler
BACKGROUND: Alcohol use typically begins during adolescence and escalates into young adulthood. This represents an important period for the establishment of alcohol use and misuse patterns, which can have psychosocial and medical consequences. Although changes in alcohol use during this time have been phenotypically characterized, their genetic nature is poorly understood. METHODS: Participants of the Avon Longitudinal Study of Parents and Children completed the Alcohol Use Disorders Identification Test (AUDIT) 4 times from age 16 to 20...
November 28, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27888512/response-to-astley-s-letter-to-the-editor
#3
LETTER
Claire D Coles, Amanda R Gailey, Jennifer G Mulle, Julie A Kable, Mary Ellen Lynch, Kenneth Lyons Jones
No abstract text is available yet for this article.
November 26, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27883222/alcohol-misuse-and-co-occurring-mental-disorders-among-new-soldiers-in-the-u-s-army
#4
Murray B Stein, Laura Campbell-Sills, Joel Gelernter, Feng He, Steven G Heeringa, Matthew K Nock, Nancy A Sampson, Xiaoying Sun, Sonia Jain, Ronald C Kessler, Robert J Ursano
BACKGROUND: Problem drinking that predates enlistment into military service may contribute to the overall burden of alcohol misuse in the Armed Forces; however, evidence bearing on this issue is limited. This study examines prevalence and correlates of alcohol misuse among new U.S. Army soldiers. METHODS: Cross-sectional survey data were collected from soldiers reporting for basic combat training. The survey retrospectively assessed lifetime alcohol consumption and substance abuse/dependence, enabling estimation of the prevalence of lifetime binge drinking and heavy drinking in a sample of 30,583 soldiers and of probable alcohol use disorder (AUD) among 26,754 soldiers with no/minimal lifetime use of other drugs...
November 24, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27883221/alcohol-exposure-causes-overexpression-of-heart-development-related-genes-by-affecting-the-histone-h3-acetylation-via-bmp-signaling-pathway-in-cardiomyoblast-cells
#5
Jin Shi, Weian Zhao, Bo Pan, Min Zheng, Lina Si, Jing Zhu, Lingjuan Liu, Jie Tian
BACKGROUND: Abusive alcohol utilization of pregnant woman may cause congenital heart disease (CHD) of fetus, where alcohol ignites histone H3 hyperacetylation leading to abnormal development of heart morphogenesis and associated genes. Knowledge about the regularized upstream genes is little, but bone morphogenetic protein (BMP) signaling may actively and prominently take part in alteration in acetylation of histone H3. The supreme objective of this study was to unearth the involvement of BMP signaling pathway in alcohol-driven hyperacetylation of histone H3 in cardiomyoblast cells...
November 24, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27883214/psychiatric-demographic-and-brain-morphological-predictors-of-relapse-after-treatment-for-an-alcohol-use-disorder
#6
Timothy C Durazzo, Dieter J Meyerhoff
BACKGROUND: Relapse in alcohol use disorders (AUD) is related to a complex interplay among multiple biological, psychiatric, psychological, and psychosocial factors, which may change dynamically during and after treatment. At treatment entry for AUD, morphological abnormalities in anterior frontal regions and the insula have been observed in those who ultimately relapse following treatment. The goal of this study was to determine whether anterior frontal and insula measures of brain thickness, surface area, and volume predict posttreatment drinking status (i...
November 24, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27883195/the-use-of-cardiac-orienting-responses-as-an-early-and-scalable-biomarker-of-alcohol-related-neurodevelopmental-impairment
#7
Diego A Mesa, Julie A Kable, Claire D Coles, Kenneth Lyons Jones, Lyubov Yevtushok, Yaroslav Kulikovsky, Wladimir Wertelecki, Todd P Coleman, Christina D Chambers
BACKGROUND: Considered the leading cause of developmental disabilities worldwide, fetal alcohol spectrum disorders (FASD) are a global health problem. To take advantage of neural plasticity, early identification of affected infants is critical. The cardiac orienting response (COR) has been shown to be sensitive to the effects of prenatal alcohol exposure and is an inexpensive, easy to administer assessment tool. The purpose of this study was to evaluate the COR effectiveness in assessing individual risk of developmental delay...
November 24, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27862017/the-effects-of-ethanol-exposure-during-distinct-periods-of-brain-development-on-oxidative-stress-in-the-adult-rat-brain
#8
Patricia S Brocardo, Joana Gil-Mohapel, Ryan Wortman, Athena Noonan, Eric McGinnis, Anna R Patten, Brian R Christie
BACKGROUND: The consumption of alcohol during pregnancy can result in abnormal fetal development and impaired brain function in humans and experimental animal models. Depending on the pattern of consumption, the dose, and the period of exposure to ethanol (EtOH), a variety of structural and functional brain deficits can be observed. METHODS: This study compared the effects of EtOH exposure during distinct periods of brain development on oxidative damage and endogenous antioxidant status in various brain regions of adult female and male Sprague Dawley rats...
November 11, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27862016/letter-to-the-editor-regarding-coles-gailey-mulle-kable-lynch-and-jones-2016-a-comparison-among-5-methods-for-the-clinical-diagnosis-of-fetal-alcohol-spectrum-disorders
#9
LETTER
Susan Astley
No abstract text is available yet for this article.
November 9, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27696442/nociceptin-receptor-as-a-target-to-treat-alcohol-use-disorder-challenges-in-advancing-medications-development
#10
Raye Z Litten
No abstract text is available yet for this article.
October 3, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27688161/prenatal-alcohol-exposure-and-pair-feeding-differentially-impact-puberty-and-reproductive-development-in-female-rats-role-of-the-kisspeptin-system
#11
Joanna Helena Sliwowska, Wendy L Comeau, Tamara S Bodnar, Linda Ellis, Joanne Weinberg
BACKGROUND: Reproductive maturation is initiated with the onset of puberty, which activates the hypothalamic-pituitary-gonadal axis and coincidences with increased expression of the hormone kisspeptin within the hypothalamus. Maturational events are sensitive to environmental factors, including alcohol, which is known to delay reproductive development. We hypothesized that, similar to alcohol's adverse effects during reproductive maturation, prenatal alcohol exposure (PAE) would alter pubertal markers, sex hormone profiles, and kisspeptin expression in the hypothalamus...
September 30, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27717039/effects-of-ethanol-on-cellular-composition-and-network-excitability-of-human-pluripotent-stem-cell-derived-neurons
#12
Zoe H Larsen, Praveen Chander, Jason A Joyner, Crina M Floruta, Tess L Demeter, Jason P Weick
BACKGROUND: Prenatal alcohol exposure (PAE) in animal models results in excitatory-inhibitory (E/I) imbalance in neocortex due to alterations in the GABAergic interneuron (IN) differentiation and migration. Thus, E/I imbalance is a potential cause for intellectual disability in individuals with fetal alcohol spectrum disorder (FASD), but whether ethanol (EtOH) changes glutamatergic and GABAergic IN specification during human development remains unknown. Here, we created a human cellular model of PAE/FASD and tested the hypothesis that EtOH exposure during differentiation of human pluripotent stem cell-derived neurons (hPSNs) would cause the aberrant production of glutamatergic and GABAergic neurons, resulting in E/I imbalance...
September 26, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27716962/acetaldehyde-disrupts-interferon-alpha-signaling-in-hepatitis-c-virus-infected-liver-cells-by-up-regulating-usp18
#13
Murali Ganesan, Larisa Y Poluektova, Dean J Tuma, Kusum K Kharbanda, Natalia A Osna
BACKGROUND: Alcohol consumption exacerbates the pathogenesis of hepatitis C virus (HCV) infection and worsens disease outcomes. The exact reasons are not clear yet, but they might be partially attributed to the ability of alcohol to further suppress the innate immunity. Innate immunity is known to be already decreased by HCV in liver cells. METHODS: In this study, we aimed to explore the mechanisms of how alcohol metabolism dysregulates IFNα signaling (STAT1 phosphorylation) in HCV(+) hepatoma cells...
September 26, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27716956/faah-gene-variation-moderates-stress-response-and-symptom-severity-in-patients-with-posttraumatic-stress-disorder-and-comorbid-alcohol-dependence
#14
Primavera A Spagnolo, Vijay A Ramchandani, Melanie L Schwandt, Laura E Kwako, David T George, Leah M Mayo, Cecilia J Hillard, Markus Heilig
BACKGROUND: A common single nucleotide polymorphism (C385A) in the human fatty acid amide hydrolase (FAAH) gene has been associated with decreased distress responses in healthy volunteers, but its role in psychiatric disorders remains unknown. Here, we obtained genotypes and carried out a secondary analysis of subjects from a trial of comorbid posttraumatic stress disorder (PTSD) and alcohol dependence (AD). We evaluated the effects of C385A variation on behavioral and biochemical biomarkers of distress responses...
September 26, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27716964/immediate-neural-plasticity-involving-reaction-time-in-a-saccadic-eye-movement-task-is-intact-in-children-with-fetal-alcohol-spectrum-disorder
#15
Angelina Paolozza, Douglas P Munoz, Donald Brien, James N Reynolds
BACKGROUND: Saccades are rapid eye movements that bring an image of interest onto the retina. Previous research has found that in healthy individuals performing eye movement tasks, the location of a previous visual target can influence performance of the saccade on the next trial. This rapid behavioral adaptation represents a form of immediate neural plasticity within the saccadic circuitry. Our studies have shown that children with fetal alcohol spectrum disorder (FASD) are impaired on multiple saccade measures...
September 22, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27650785/impact-of-the-innate-immune-response-in-the-actions-of-ethanol-on-the-central-nervous-system
#16
Jorge Montesinos, Silvia Alfonso-Loeches, Consuelo Guerri
The innate immune response in the central nervous system (CNS) participates in both synaptic plasticity and neural damage. Emerging evidence from human and animal studies supports the role of the neuroimmune system response in many actions of ethanol (EtOH) on the CNS. Research studies have shown that alcohol stimulates brain immune cells, microglia, and astrocytes, by activating innate immune receptors Toll-like receptors (TLRs) and NOD-like receptors (inflammasome NLRs) triggering signaling pathways, which culminate in the production of pro-inflammatory cytokines and chemokines that lead to neuroinflammation...
September 21, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27650665/assays-of-gamma-glutamyl-transferase-and-carbohydrate-deficient-transferrin-combination-from-maternal-serum-improve-the-detection-of-prenatal-alcohol-exposure
#17
Onni Niemelä, Solja Niemelä, Annukka Ritvanen, Mika Gissler, Aini Bloigu, Marja Vääräsmäki, Eero Kajantie, Martha M Werler, Heljä-Marja Surcel
BACKGROUND: Alcohol use during pregnancy leads to detrimental effects on fetal development. As self-reports by mothers are known to be unreliable for assessing prenatal alcohol exposure, there is a need for sensitive and specific biomarkers for identifying those at risk for alcohol-affected offspring. METHODS: We measured serum gamma-glutamyl transferase (GGT), carbohydrate-deficient transferrin (CDT), a mathematically formulated combination of GGT and CDT (GGT-CDT), and ethylglucuronide (EtG) concentrations from 1,936 mothers with a positive (n = 480) or negative (n = 1,456) history of alcohol use at the time of pregnancy...
September 21, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27647657/up-regulation-of-pkr-signaling-pathway-by-ethanol-displays-an-age-of-onset-dependent-relationship
#18
Jeremy W Duncan, Shakevia Johnson, Xiao Zhang, Baoying Zheng, Jia Luo, Xiao-Ming Ou, Craig A Stockmeier, Jun Ming Wang
BACKGROUND: Ethanol (EtOH) neurotoxicity can result in devastating effects on brain and behavior by disrupting homeostatic signaling cascades and inducing cell death. One such mechanism involves double-stranded RNA activated protein kinase (PKR), a primary regulator of protein translation and cell viability in the presence of a virus or other external stimuli. EtOH-mediated up-regulation of interferon-gamma (IFN-γ; the oxidative stress-inducible regulator of PKR), PKR, and its target, p53, are still being fully elucidated...
September 20, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27906460/abstracts
#19
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27862022/binge-ethanol-consumption-increases-inflammatory-pain-responses-and-mechanical-and-cold-sensitivity-tigecycline-treatment-efficacy-shows-sex-differences
#20
Susan E Bergeson, Henry Blanton, Joseph M Martinez, David C Curtis, Caitlyn Sherfey, Brandon Seegmiller, Patrick C Marquardt, Jessica A Groot, Clayton L Allison, Christian Bezboruah, Josée Guindon
BACKGROUND: Physicians have long reported that patients with chronic pain show higher tendencies for alcohol use disorder (AUD), and AUD patients appear to have higher pain sensitivities. The goal of this study was to test 2 hypotheses: (i) binge alcohol consumption increases inflammatory pain and mechanical and cold sensitivities; and (ii) tigecycline is an effective treatment for alcohol-mediated-increased pain behaviors and sensitivities. Both female and male mice were used to test the additional hypothesis that important sex differences in the ethanol (EtOH)-related traits would be seen...
December 2016: Alcoholism, Clinical and Experimental Research
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