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Leukemia Research

Judith Neukirchen-Strapatsas, Heinz Tuechler, Matteo Della Porta, Pierre Fenaux, Agnès Guerci, Rainer Haas, Marianna Rossi, Rosa Sapena, Wolfgang R Sperr, Corinna Strupp, Aspasia Stamatoullas, Peter Valent, Ulrich Germing, John M Bennett
In patients with myelodysplastic syndromes (MDS) the impact of the percentage of erythroid precursors in the bone marrow has been the subject of considerable debate, especially with regard to prognosis. We examined the prognostic impact of the percentage of erythroid cells in the bone marrow (bmery) in 2453 primary untreated MDS patients in a retrospective multi-center analysis. Bmery were quantified in bone marrow smears at the time of diagnosis and were correlated with overall survival (OS) and AML evolution...
December 28, 2018: Leukemia Research
Hamid Sayar, Larry D Cripe, Antoine N Saliba, Mohammad Abu Zaid, Heiko Konig, H Scott Boswell
No abstract text is available yet for this article.
December 24, 2018: Leukemia Research
Valerie Broderick, Katherine Waghorn, Stephen E Langabeer, Michael Jeffers, Nicholas C P Cross, Patrick J Hayden
No abstract text is available yet for this article.
December 24, 2018: Leukemia Research
Hong Luo, Suo Zhang, Ke Li, Xing-Hua Chen, Yan-Chun Li, Yuan Sun, Li-Feng Liu, Hui-Yang Yu, Hong-Hu Zhu
No abstract text is available yet for this article.
December 23, 2018: Leukemia Research
Emanuele Cencini, Alberto Fabbri, Anna Sicuranza, Monica Bocchia
No abstract text is available yet for this article.
December 22, 2018: Leukemia Research
Staci L Haney, Michelle L Varney, Hannah R Safranek, Yashpal S Chhonker, Narendran G-Dayanandan, Geoffrey Talmon, Daryl J Murry, Andrew J Wiemer, Dennis L Wright, Sarah A Holstein
Tropolones are naturally occurring seven-membered non-benzenoid aromatic compounds that are of interest due to their cytotoxic properties. MO-OH-Nap is a novel α-substituted tropolone that induces caspase cleavage and upregulates markers associated with the unfolded protein response (UPR) in multiple myeloma (MM) cells. Given previous reports that tropolones may function as iron chelators, we investigated the effects of MO-OH-Nap, as well as the known iron chelator deferoxamine (DFO), in MM cells in the presence or absence of supplemental iron...
December 21, 2018: Leukemia Research
Geetanjali R Kamath, Douglas Tremblay, Alexander Coltoff, Jessica Caro, Guido Lancman, Sheena Bhalla, Vesna Najfeld, John Mascarenhas, Emanuela Taioli
No abstract text is available yet for this article.
December 19, 2018: Leukemia Research
Gurvinder Kaur, Ritu Gupta, Nitin Mathur, Lata Rani, Lalit Kumar, Atul Sharma, Vishwajeet Singh, Anubha Gupta, Om Dutt Sharma
Complex Chromosomal Rearrangements (CCRs) are increasingly being reported as genetic risk factors of clinical significance in cancer owing to their identification using high resolution whole genome profiling technologies. This study employed high resolution CGH + SNP microarrays for whole genome copy number variations (CNV) profiling and identified CCRs in 11/107(10%) newly diagnosed Multiple Myeloma (MM) patients. Six patients exhibited Chromothripsis (CTH) among seven chromosomes that were confirmed with automated CTLPscanner web tool and; five cases displayed chromoplexy (CPL) which involved multiple chromosomes...
December 15, 2018: Leukemia Research
Dries Deeren
No abstract text is available yet for this article.
December 14, 2018: Leukemia Research
Hoon Seok Kim, Eunhee Han, Woori Jang, Myungshin Kim, Yonggoo Kim, Kyungja Han, Hee-Je Kim, Bin Cho
No abstract text is available yet for this article.
December 11, 2018: Leukemia Research
Martina Panebianco, Oreste Bagni, Natalia Cenfra, Sergio Mecarocci, Elettra Ortu La Barbera, Luca Filippi, Giovanni Codacci-Pisanelli, Tommaso Biondi, Andrea Laghi, Giuseppe Cimino
We compared 2-[fluorine-18] fluoro-2-deoxy-d-glucose PET-CT and contrast-enhanced computed tomography (CECT) in 62 consecutive patients with newly diagnosed Hodgkin Lymphoma (HL), aiming to provide evidences that may spare CECT from the staging procedures of HL patients. Among a total of 1448 nodal sites examined, disease involvement was detected in 232 (16%) and 280 (19.3%) nodal areas by CECT and PET-CT, respectively (P < 0.01). Sensitivity of CECT in detecting disease involvement ranged from 0% for internal mammary region (7 cases) and Waldayer's ring (1 case) to 100% for mediastinum...
December 5, 2018: Leukemia Research
L F Mantovani, F P S Santos, G F Perini, C M B Nascimento, L P Silva, C K Wroclawski, B P Esposito, M S S Ribeiro, E D R P Velloso, C H Nomura, F U Kay, R H Baroni, N Hamerschlak, S Schuster
INTRODUCTION: Transfusion-dependent anemia and iron overload are associatedwith reduced survival in myelodysplastic syndrome (MDS). This cross-sectional study aimed to evaluate the prevalence of hepatic and cardiac overload in patients with MDS as measured by T2* magnetic resonance imaging (MRI), and its correlation with survival. METHODS: MDS or chronic myelomonocytic leukemia patients had iron overload evaluated by T2* MRI. HIO was considered when hepatic iron concentration ≥ 2 g/mg...
December 4, 2018: Leukemia Research
Maël Heiblig, Pierre Sujobert, Sandrine Hayette, Marie Balsat, Mohamed Elhamri, Gilles Salles, Xavier Thomas
No abstract text is available yet for this article.
November 29, 2018: Leukemia Research
Cristiano de Queiroz Mendonca, Marcelle Vieira Freire, Simone Santana Viana, Mayo Kayann Guerra Silva Tavares, Wallace Marcelo Almeida Silva, Rosana Cipolotti
OBJECTIVE: To characterize ocular manifestations (OM) of pediatric patients treating for acute lymphoblastic leukemia (ALL) and to evaluate whether they are associated with well-described predictive risk factors for relapse, protocol (1999 or 2009), gender and cerebrospinal fluid infiltration. METHODS: A prospective cohort study was conducted in children and adolescents with ALL from January 2013 to December 2017. The patients underwent ophthalmologic evaluations before starting treatment (D0), on the eighth day (D8), at the 28th day (D28), and at six months (D6 months)...
November 29, 2018: Leukemia Research
Carla Filì, Anna Candoni, Maria Elena Zannier, Jacopo Olivieri, Silvia Imbergamo, Manuela Caizzi, Gianpaolo Nadali, Eros Di Bona, Anna Ermacora, Michele Gottardi, Davide Facchinelli, Rosanna Ciancia, Davide Lazzarotto, Maria Vittoria Dubbini, Gianluca Festini, Filippo Gherlinzoni, Maria Grazia Michieli, Gianpietro Semenzato, Renato Fanin
BACKGROUND: The hypomethylating agent Decitabine (DAC) is a valuable treatment option in acute myeloid leukemia (AML), particularly in elderly patients (pts) not suitable for intensive chemotherapy (CHT). However, limited data are available about efficacy and safety of DAC in clinical practice. PATIENTS AND METHODS: We retrospectively reviewed data of 104 AML pts treated with DAC in eight Italian Hematological Centers from 2015 to 2017. The objective of this study was to evaluate the efficacy and safety of DAC in older AML pts outside of clinical trial...
November 28, 2018: Leukemia Research
Rik A Brooimans, Vincent H J van der Velden, Nancy Boeckx, Jennita Slomp, Frank Preijers, Jeroen G Te Marvelde, Ngoc M Van, Antoinette Heijs, Erik Huys, Bronno van der Holt, Georgine E de Greef, Angele Kelder, Gerrit Jan Schuurhuis
Flow-cytometric detection of now termed measurable residual disease (MRD) in acute myeloid leukemia (AML) has proven to have an independent prognostic impact. In a previous multicenter study we developed protocols to accurately define leukemia-associated immunophenotypes (LAIPs) at diagnosis. It has, however, not been demonstrated whether the use of the defined LAIPs in the same multicenter setting results in a high concordance between centers in MRD assessment. In the present paper we evaluated whether interpretation of list-mode data (LMD) files, obtained from MRD assessment of previously determined LAIPs during and after treatment, could reliably be performed in a multicenter setting...
November 27, 2018: Leukemia Research
Ki-Hoon Kang, Soo-Hyun Kim, Soo-Young Choi, Hae-Lyun Yoo, Mi-Young Lee, Hye-Young Song, Kyung-Mi Kee, Ji-Hyung Suh, Seon-Young Yang, Eun-Jung Jang, Sung-Eun Lee, Dong-Wook Kim
To analyze the pattern of multiple mutations detected by Sanger sequencing (SS), we performed subcloning sequencing using 218 samples from 45 patients with tyrosine kinase inhibitor resistant chronic myeloid leukemia. At the first time of multiple mutation detection by SS (baseline), a total of 19 major mutations from 45 samples were detected; these mutations were found in the following order: T315I (68.9%), E255 K (33.3%), Y253H (13.3%), G250E (13.3%), and F317 L (11.1%). Subcloning sequencing of 900 baseline colonies identified 556 different mutant types, and 791 among the 900 were colonies with major mutations (87...
November 27, 2018: Leukemia Research
B Marcellino, R Hoffman, J Mascarenhas
No abstract text is available yet for this article.
November 22, 2018: Leukemia Research
Isabel S Naarmann-de Vries, Yvonne Sackmann, Felicitas Klein, Antje Ostareck-Lederer, Dirk H Ostareck, Edgar Jost, Gerhard Ehninger, Tim H Brümmendorf, Gernot Marx, Christoph Röllig, Christian Thiede, Martina Crysandt
Acute myeloid leukemia is an aggressive disease that arises from clonal expansion of malignant hematopoietic precursor cells of the bone marrow. Deletions on the long arm of chromosome 9 (del(9q)) are observed in 2% of acute myeloid leukemia patients. Our deletion analysis in a cohort of 31 del(9q) acute myeloid leukemia patients further supports the importance of a minimally deleted region composed of seven genes potentially involved in leukemogenesis: GKAP1, KIF27, C9ORF64, HNRNPK, RMI1, SLC28A3 and NTRK2...
November 17, 2018: Leukemia Research
Carol Fries, Richard Burack
No abstract text is available yet for this article.
November 16, 2018: Leukemia Research
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