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Clinical Therapeutics

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https://www.readbyqxmd.com/read/30006070/challenge-and-change-at-the-forefront-of-regenerative-medicine
#1
EDITORIAL
Christopher-Paul Milne, Kenneth I Kaitin
No abstract text is available yet for this article.
July 10, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/30006069/cost-effectiveness-of-daratumumab-based-triplet-therapies-in-patients-with-relapsed-or-refractory-multiple-myeloma
#2
Tian-Tian Zhang, Sen Wang, Ning Wan, Li Zhang, Zu-Gui Zhang, Jie Jiang
PURPOSE: The prominent efficacy of the addition of daratumumab to lenalidomide and dexamethasone (DRd) or the addition to bortezomib and dexamethasone (DVd) was proven previously for patients with relapsed or refractory multiple myeloma (RRMM). However, the cost-effectiveness of adding daratumumab to traditional doublet regimens versus doublet regimens alone (DRd vs Rd; DVd vs Vd) was unknown. METHODS: We developed a semi-Markov model by using a US payer perspective and 10-year time horizon to estimate the cost and quality-adjusted life years (QALYs) for treatments...
July 10, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29983266/hepatitis-c-management-simplification-from-test-to-cure-a-framework-for-primary-care-providers
#3
Shashi N Kapadia, Kristen M Marks
This article proposes a strategy for primary care providers to begin treating patients with hepatitis C virus (HCV). We are motivated by the need to expand HCV treatment and by developments that have simplified treatment for most patients. This article presents 5 steps to achieving quality HCV treatment in the primary care setting: (1) accurate diagnosis via reflex testing; (2) risk stratification and identifying comorbidities via pretreatment evaluation; (3) simple, once-daily, pan-genotypic HCV treatment regimens; (4) minimized on-treatment monitoring: and (5) posttreatment monitoring and high-quality care for comorbidities such as cirrhosis and injection drug use...
July 5, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29983265/elimination-of-vertical-transmission-of-hepatitis-b-in-africa-areview-of-available-tools-and-new-opportunities
#4
REVIEW
Jodie Dionne-Odom, Basile Njei, Alan T N Tita
PURPOSE: This review article focuses on preventing vertical transmission of hepatitis B virus (HBV) among pregnant women living in sub-Saharan Africa (SSA), where disease is endemic and the estimated maternal HBV seroprevalence is >8%. Available interventions that have been studied in low- and middle-income countries are compared in terms of efficacy and effectiveness in clinical practice. Global disease-elimination targets, barriers to HBV-prevention efforts, and critical research gaps are discussed...
July 5, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29983264/preventive-effects-of-renin-angiotensin-system-inhibitors-on-oxaliplatin-induced-peripheral-neuropathy-a-retrospective-observational-study
#5
Mami Uchida, Hitoshi Kawazoe, Shingo Takatori, Hiroyuki Namba, Ryuji Uozumi, Akihiro Tanaka, Hiromu Kawasaki, Hiroaki Araki
PURPOSE: Oxaliplatin-induced peripheral neuropathy has remained an unresolved issue in clinical practice. Our previous study hypothesized that inhibition of the renin-angiotensin system (RAS) may produce a preventive effect on oxaliplatin-induced neuropathy. The aim of this study was to clarify whether RAS inhibitors prevent oxaliplatin-induced peripheral neuropathy. METHODS: This study retrospectively analyzed data from cancer patients who had received chemotherapy including oxaliplatin and were treated with or without RAS inhibitors...
July 5, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29958729/establishment-of-the-national-consortium-for-regenerative-medicine-and-national-regenerative-medicine-database-in-japan
#6
REVIEW
Kiyoshi Okada, Yoji Sato, Daisuke Sugiyama, Yoshiki Sawa
With its aim to regain the function of organs that are damaged by illness or injury, regenerative medicine has become the global focus of research. To accelerate the development and establishment of sufficient safety measures in regenerative medicine in Japan, the Pharmaceuticals and Medical Devices Act and the Act on Safety of Regenerative Medicine were enacted in 2014. Advancements in regenerative medicine are anticipated to draw attention toward the development of a system that consolidates and uses valuable data from studies performed from premarketing to postmarketing stages...
June 26, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29945738/a-randomized-multicenter-double-blind-phase-iii-study-to-evaluate-the-efficacy-on-allergic-rhinitis-and-safety-of-a-combination-therapy-of-montelukast-and-levocetirizine-in-patients-with-asthma-and-allergic-rhinitis
#7
Mi-Kyeong Kim, Sook Young Lee, Hae-Sim Park, Ho Joo Yoon, Sang-Ha Kim, Young Joo Cho, Kwang-Ha Yoo, Soo-Keol Lee, Hee-Kyoo Kim, Jung-Won Park, Heung-Woo Park, Jin-Hong Chung, Byoung Whui Choi, Byung-Jae Lee, Yoon-Seok Chang, Eun-Jung Jo, Sang-Yeub Lee, You Sook Cho, Young-Koo Jee, Jong-Myung Lee, Jina Jung, Choon-Sik Park
PURPOSE: The aim of this study was to evaluate the efficacy and safety of a fixed-dose combination of montelukast and levocetirizine in patients with perennial allergic rhinitis with mild to moderate asthma compared with the efficacy and safety of montelukast alone. METHODS: This study was a 4-week, randomized, multicenter, double-blind, Phase III trial. After a 1-week placebo run-in period, the subjects were randomized to receive montelukast (10mg/day, n = 112) or montelukast (10 mg/day)/levocetirizine (5 mg/day) (n = 116) treatment for 4 weeks...
June 24, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29941151/the-lack-of-effect-of-food-on-the-pharmacokinetics-of-zx008-fenfluramine-oral-solution-results-of-a-single-dose-two-period-crossover-study
#8
Arnold Gammaitoni, Steven Smith, Brooks Boyd
PURPOSE: Fenfluramine is being developed as a low-dose adjunctive treatment for seizures in patients with Dravet syndrome and other epileptic encephalopathies, including Lennox-Gastaut syndrome. Most patients with Dravet syndrome receive multiple antiepileptic drugs, making it challenging for caregivers to track correct administration times. The present Phase I study was conducted to determine the effect of food on the pharmacokinetic properties of fenfluramine. METHODS: Healthy nonsmoking subjects aged 18 to 50years were enrolled in an open-label, crossover, Phase I pharmacokinetic and safety profile study and received 2 single 0...
June 22, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29891234/a-mentation-on-mold
#9
EDITORIAL
Richard I Shader
No abstract text is available yet for this article.
June 8, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29880330/effects-of-mycotoxins-on-neuropsychiatric-symptoms-and-immune-processes
#10
REVIEW
Aarane M Ratnaseelan, Irene Tsilioni, Theoharis C Theoharides
PURPOSE: The effects of air pollutants have been receiving increased attention both clinically and in the media. One such pollutant is mold, fungal growth in the form of multicellular filaments known as hyphae. The growth of molds is omnipresent not only in outdoor settings but also in indoor environments containing excessive amounts of moisture. METHODS: PubMed was searched for relevant articles using terms such as mold, mycotoxins, fungi, immunity, inflammation, neurodevelopment, cognition, Alzheimer's, and autism...
June 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29861191/a-large-case-series-of-successful-treatment-of-patients-exposed-to-mold-and-mycotoxin
#11
William J Rea
PURPOSE: The goal of this study was to present the results of treatment of 100 chemically sensitive and chronically mold-exposed patients, who continued to be disabled even after decontamination of their houses or work places or they were physically removed from their sources of mold. METHODS: Molds were identified, serum anti-mold immunoglobulin G antibodies were measured, patients were skin-tested, immunologic abnormalities were recorded, and objective neurologic tests were performed in a subset of patients...
June 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29861190/emerging-diabetes-research-from-early-investigators
#12
EDITORIAL
John G Ryan
No abstract text is available yet for this article.
June 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29859636/mold-and-immunity
#13
EDITORIAL
Theoharis C Theoharides
No abstract text is available yet for this article.
June 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29857919/efficacy-and-safety-of-ezetimibe-and-rosuvastatin-combination-therapy-versus-those-of-rosuvastatin-monotherapy-in-patients-with-primary-hypercholesterolemia
#14
Woohyeun Kim, Yeonyee E Yoon, Sung-Hee Shin, Jang-Whan Bae, Bum-Kee Hong, Soon Jun Hong, Ki Chul Sung, Seung Hwan Han, Weon Kim, Moo-Yong Rhee, Sang-Hyun Kim, Sang Eun Lee, Min Su Hyon, Gyo-Seung Hwang, Jang Won Son, Jang-Young Kim, Min Kyu Kim, Sang Wook Kim, Jae-Hyeong Park, Jin Ho Shin, Chang Gyu Park
PURPOSE: The aim of this study was to evaluate the safety and efficacy of combination treatment of rosuvastatin with ezetimibe in patients with primary hypercholesterolemia. METHODS: This multicenter, randomized, double-blind study comprised a main study and an extension study. In the main study, the efficacy and safety of a combination of rosuvastatin (5, 10, and 20 mg) with ezetimibe (10 mg) were compared with those of rosuvastatin (5, 10, and 20 mg) alone. The subjects who achieved the National Cholesterol Education Program Adult Treatment Panel III LDL-C goal in the main study and agreed to a further study were enrolled for the extension study...
June 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29807668/use-of-galactomannan-antigen-and-aspergillus-dna-real-time-polymerase-chain-reaction-as-routine-methods-for-invasive-aspergillosis-in-immunosuppressed-children-in-greece
#15
Georgia Vrioni, Kalliopi Theodoridou, Costas Tsiamis, Maria Mavrouli, Violeta Kapsimali, Dimitrios Rigopoulos, Athanasios Tsakris
PURPOSE: Invasive aspergillosis (IA) remains a critical issue in immunosuppressed patients. Detection of galactomannan antigen (GM) in serum samples is included as a criterion of IA by the European Organization for the Research and Treatment of Cancer/Mycoses Study Group. Nevertheless, Aspergillus DNA detection by polymerase chain reaction (PCR) has not yet been included because clinical data validation is lacking. The present study describes the simultaneous performance of GM and PCR tests as routine methods for IA diagnosis...
June 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29803535/case-reports-and-informed-consent
#16
EDITORIAL
Richard I Shader
No abstract text is available yet for this article.
June 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29803534/effects-of-nemonoxacin-on-thorough-ecg-qt-qtc-interval-a-randomized-placebo-and-positive-controlled-crossover-study-in-healthy-chinese-adults
#17
Caiyun Zhao, Yuan Lv, Xiangyan Li, Fang Hou, Xuzhu Ma, Minji Wei, Zisheng Kang, Lanqing Cui, Yahong Xia, Yan Liu, Jihong Tian
PURPOSE: Nemonoxacin, a nonfluorinated quinolone, has been approved in Taiwan and mainland China for the treatment of bacterial infection. Whether nemonoxacin is associated with the adverse events of other quinolones, such as the risk for QT-interval prolongation, which has led to the withdrawal of several fluoroquinolones from the market, needs to be elucidated. METHODS: The effects of nemonoxacin on thorough QT/QTc interval was investigated in this randomized, placebo- and positive-controlled crossover study conducted according to the International Conference on Harmonisation E14 guideline...
June 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29803533/understanding-the-patient-s-journey-in-the-diagnosis-and-treatment-of-multiple-sclerosis-in-clinical-practice
#18
Jay Visaria, Nina Thomas, Tao Gu, Joseph Singer, Hiangkiat Tan
PURPOSE: The aim of this study was to describe the treatment journey of patients with multiple sclerosis (MS). METHODS: This study was conducted in 2 phases. The first consisted of a claims-based analysis of data from patients diagnosed with MS between October 1, 2010, and May 31, 2014. Study patients were aged ≥18 years, had ≥12 months of continuous eligibility before and after the earliest MS diagnosis (index date), ≥1 disease-modifying therapy (DMT) claim postindex, and no claims with a code for DMT or MS during the 12-month preindex period...
June 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29803532/canada-s-study-of-adherence-outcomes-in-patients-receiving-adalimumab-3-year-results-from-the-companion-study
#19
John K Marshall, Louis Bessette, Neil H Shear, Gerald Lebovic, Jennifer Glass, Brad Millson, Tania Gaetano, Sandra Gazel, Martin G Latour, Marie-Claude Laliberté, J Carter Thorne
PURPOSE: The aim of this study was to quantify the association between receiving care-coach calls (CCCs), a service provided by a patient-support program (PSP) in Canada, and persistence with and adherence to adalimumab therapy over a 3-year period in patients with immune-related inflammatory diseases (IMID). METHODS: COMPANION, a longitudinal, retrospective cohort study, was conducted using patient-level data from the PSP combined with those from a longitudinal pharmacy-transaction database in patients initiating adalimumab therapy between 2010 and 2012...
June 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29801753/b-lymphocytes-in-rheumatoid-arthritis-and-the-effects-of-anti-tnf-%C3%AE-agents-on-b-lymphocytes-a-review-of-the-literature
#20
REVIEW
Ozlem Pala, Alain Diaz, Bonnie B Blomberg, Daniela Frasca
PURPOSE: The aim of this article was to review published research related to B lymphocytes in rheumatoid arthritis, their role in the pathogenesis of the disease, the effects of tumor necrosis factor (TNF)-α inhibitors on B lymphocytes, the risk for infection, and responses to vaccines. METHODS: A PubMed search was conducted to review recent advances related to B lymphocytes and the effects of anti-TNF-α on B lymphocytes in rheumatoid arthritis. FINDINGS: B lymphocytes play an important role in the pathogenesis of rheumatoid arthritis...
June 2018: Clinical Therapeutics
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