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Journal of Medical Virology

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https://www.readbyqxmd.com/read/28817198/valuable-antibody-detection-method-for-classifying-hepatitis-e-virus-genotypes
#1
Chenyan Zhao, Yansheng Geng, Weijing Huang, Hongxia Ma, Youchun Wang
Nucleotide-based methods are conventionally used to classify the hepatitis E virus (HEV) genotypes. A serological enzyme immunoassay (EIA) using open reading frame 3 (ORF3) C-terminal peptides was developed to conveniently and accurately classify and evaluate the genotypes of HEV. The sera of mice immunized with HEV genotype 1, 3 and 4 reacted highly specifically to the peptides of the corresponding genotypes. Most (84.2%) clinical sera infected with HEV genotype 4 were positive for anti-HEV antibodies when tested with the ORF3 peptides of genotype 4, but were negative for genotypes 1 and 3...
August 17, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28817197/estimating-seroprevalence-of-herpes-simplex-virus-type-1-among-different-middle-east-and-north-african-male-populations-residing-in-qatar
#2
Gheyath K Nasrallah, Soha R Dargham, Layla I Mohammed, Laith J Abu-Raddad
BACKGROUND: HSV-1 epidemiology in the Middle East and North Africa (MENA) remains poorly understood. Our study aimed to measure HSV-1 antibody prevalence (seroprevalence) and its age-distribution among select MENA populations residing in Qatar. METHODS: Sera were collected from male blood donors attending Hamad Medical Corporation 2013-2015. A total of 2,077 sera were tested for anti-HSV-1 antibodies using HerpeSelect® 1 ELISA IgG kits (Focus Diagnostics, USA)...
August 17, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28815644/role-of-%C3%AE-%C3%AE-t-cells-in-exacerbated-airway-inflammation-during-reinfection-of-neonatally-primed-mice-in-adulthood
#3
Jianqi Wu, Lei Xu, Xu Han, Haiyan Hu, Feifei Qi, Song Bai, Ruonan Chai, Yuee Teng, Beixing Liu
Age at primary infection with respiratory syncytial virus (RSV) is a crucial factor in determining the outcome of reinfection. However, how neonatal RSV infection affects the immune system and renders the host more susceptible to reinfection in later life is poorly understood. In the present study, by using BALB/c mice that were first infected with RSV as neonates, the role of γδ T cells in the development of airway inflammation during reinfection in adulthood was investigated. We found that neonatal RSV infection resulted in an aggravated infiltration of mononuclear cells in bronchoalveolar lavage (BAL) fluids, in parallel with a significant increase in the levels of type 2 cytokines in lungs on day 4 after reinfection...
August 16, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28792077/the-combination-of-oseltamivir-with-azithromycin-does-not-show-additional-benefits-over-oseltamivir-monotherapy-in-mice-infected-with-influenza-a-h1n1-pdm2009-virus
#4
Clément Fage, Andrés Pizzorno, Chantal Rhéaume, Yacine Abed, Guy Boivin
The combination of azithromycin, an immunomodulator, with oseltamivir was compared to oseltamivir monotherapy in a lethal BALB/c model of influenza A(H1N1)pdm09 infection. Groups of 14-16 mice received oral oseltamivir (10 mg/kg once daily for 5 days, starting at day 2 post-inoculation) alone or combined to azithromycin (a single 100 mg/kg dose, injected intraperitoneally at day 3 post-inoculation). Based on survival rates, lung viral titers and pro-inflammatory cytokine levels, the combination therapy did not provide obvious additional clinical/virological benefits over oseltamivir monotherapy...
August 9, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28792076/high-prevalence-of-syphilis-hbv-and-hcv-co-infection-and-low-rate-of-effective-vaccination-against-hepatitis-b-in-hiv-infected-patients-in-west-china-hospital
#5
Tingting Yang, Qixia Chen, Dongdong Li, Tingting Wang, Yu Gou, Bin Wei, Chuanmin Tao
Background and Aims To investigate the epidemiological features and risk factors of HBV, HCV and syphilis infection among HIV-infected patients in West China Hospital. Methods A retrospective study was conducted with HIV-infected patients from 2014 to 2016 in West China hospital, SCU. Serum makers for HBV, HCV and syphilis were detected. Results Among 894 HIV-infected patients, the prevalence of HIV/HBV, HIV/HCV, HIV/syphilis co-infections was 14.4%, 5.7%, and 18.9% respectively. HIV/HBV/HCV, HIV/HCV/syphilis and HIV/HBV/syphilis triple co-infection was 7 (0...
August 9, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28792071/high-prevalence-of-hbv-infection-detection-of-subgenotypes-f1b-a2-and-d4-and-differential-risk-factors-among-mexican-risk-populations-with-low-socioeconomic-status
#6
Alexis Jose-Abrego, Arturo Panduro, Nora A Fierro, Sonia Roman
Hepatitis B virus (HBV) infection may be underestimated among high-risk individuals in regions of low HBs antigenemia. This study aimed to assess HBV serological markers, genotypes and risk factors in Mexican patients with risk of HBV infection and low socioeconomic status. Demographics, clinical and risk factor data were collected in patients with HIV (n = 289), HCV (n = 243), deferred blood donors (D-BD) (n = 83), and two native populations, Mixtecos (n = 57) and Purepechas (n = 44). HBV infection was assessed by HBsAg, anti-HBc and HBV-DNA testing...
August 9, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28792064/evidence-of-increasing-diversification-of-zika-virus-strains-isolated-in-the-american-continent
#7
Fabián Aldunate, Fabiana Gámbaro, Alvaro Fajardo, Martín Soñora, Juan Cristina
Zika virus (ZIKV) is a member of the family Flaviviridae. ZIKV emerged in Brazil in 2015, causing an unprecedented epidemic and since then the virus has rapidly spread throughout the Americas. These facts highlight the need of detailed phylogenetic studies to understand the emergence, spread and evolution of ZIKV populations. For these reasons, a Bayesian coalescent Markov Chain Monte Carlo analysis of complete genome sequences of ZIKV strains recently isolated in the American continent was performed. The results of these studies revealed an increasing diversification of ZIKV strains in different genetic lineages and co-circulation of distinct genetic lineages in several countries in the region...
August 9, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28786502/a-safe-and-reliable-neutralization-assay-based-on-pseudovirus-to-measure-neutralizing-antibody-titer-against-poliovirus
#8
Shaohua Liu, Dongmei Song, Han Bai, Weiwei Lu, Xinxian Dai, Chunsheng Hao, Zhongyang Zhang, Huijie Guo, Yue Zhang, Xiuling Li
With the promotion of inactivated poliomyelitis vaccine (IPV) and live attenuated oral poliomyelitis vaccine (OPV), the global reported cases of poliomyelitis have reduced sharply from 0.35 million in 1988 to 74 in 2015. The Polio Eradication & Endgame Strategic Plan published by WHO in 2013 included the strategy of implementation of poliovirus safe handling and containment measures to minimize the risks of facility-associated reintroduction of virus into the polio-free community to prevent the re-import of poliovirus...
August 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28786495/type-specific-human-papillomavirus-prevalence-in-cervical-intraepithelial-neoplasia-and-cancer-in-iran
#9
Nasrin Heydari, Mahin Ahangar Oskouee, Tayebeh Vaezi, Zabihollah Shoja, Heidar Ali Esmaeili, Rasool Hamkar, Shohreh Shahmahmoodi, Somayeh Jalilvand
In Iran, HPV vaccination is not currently included in the national vaccination program and there are no comprehensive approaches to cervical screening program. Regional data on distribution of HPV types in women is important to predict the impact of current HPV vaccines. Although several studies on distribution of HPV types in cervical precancer and cancer have been conducted in Iran, in most of them HPV positive samples were subjected to specific-primer genotyping (mainly 16 and 18), and leaving the other HPV genotypes almost undetermined...
August 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28776712/distinct-changing-profiles-of-hepatitis-a-and-e-virus-infection-among-patients-with-acute-hepatitis-in-mongolia-the-first-report-of-the-full-genome-sequence-of-a-novel-genotype-1-hepatitis-e-virus-strain
#10
Bira Tsatsralt-Od, Putu Prathiwi Primadharsini, Tsutomu Nishizawa, Hiroshi Ohnishi, Shigeo Nagashima, Masaharu Takahashi, Suljid Jirintai, Dulmaa Nyamkhuu, Hiroaki Okamoto
In January 2012, Mongolia started a hepatitis A vaccination program, which has not yet been evaluated. The first occurrence of autochthonous acute hepatitis E in 2013, caused by genotype 4 hepatitis E virus (HEV), suggests the need for a routine study to monitor its prevalence. One hundred fifty-four consecutive patients who were clinically diagnosed with acute hepatitis between 2014 and 2015 in Ulaanbaatar, Mongolia were studied. By serological and molecular testing followed by sequencing and phylogenetic analysis, only one patient (0...
August 4, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28771777/high-risk-papillomavirus-infection-among-women-living-with-human-immunodeficiency-virus-brazilian-multicentric-study
#11
Angelica E Miranda, Mariangela F Silveira, Ana Gabriela Travassos, Teresinha Tenório, Isabel Cristina Chulvis do Val, Leonor de Lannoy, Hortensio Simões de Mattos Junior, Newton Sergio de Carvalho
BACKGROUND: Cervical cancer is an important health issue in Latin America. Although HPV infections can have spontaneous clearance, persistence of high-risk (HR) HPV is a risk factor for cervical cancer among women and it is even higher in HIV-infected women. OBJECTIVES: to determine the prevalence of HR-HPV and risk factors among HIV-infected women attending reference services for HIV/AIDS in different regions of Brazil. METHODS: Cross-sectional study conducted among HIV-infected women attended at referral care centers for HIV/AIDS in nine states of Brazil...
August 3, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28771766/impact-of-coxsackievirus-a6-emergence-on-hand-foot-and-mouth-disease-epidemic-in-osaka-city-japan
#12
Daiki Kanbayashi, Atsushi Kaida, Seiji P Yamamoto, Yuki Hirai, Hideyuki Kubo, Ryoko Fujimori, Noritaka Hakui, Hidetetsu Hirokawa, Nobuhiro Iritani
Hand, foot, and mouth disease (HFMD) is an acute febrile illness characterized by fever; sore throat; and vesicular eruptions on the hands, feet, and oral mucosa. Until 2010, HFMD was predominantly associated with enterovirus (EV) A71 and coxsackievirus (CV) A16 in Japan. In 2011, CV-A6 emerged as a primary causative agent, causing the largest HFMD epidemic in Japan since 1981. Since then, CV-A6 has caused large HFMD epidemics every 2 years. The phylogenetic analysis of complete Viral Protein 1 (VP1) sequences revealed that most CV-A6 strains detected from 2011 to 2015 in Osaka City were classified into a different clade compared with CV-A6 strains detected from 1999 until 2009...
August 3, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28734074/association-of-clinical-and-serological-parameters-of-systemic-lupus-erythematosus-patients-with-epstein-barr-virus-antibody-profile
#13
Chougule D, Nadkar M, Rajadhyaksha A, Pandit P, Surve P, Dawkar N, Khadilkar P, Patwardhan M, Kaveri Sv, Ghosh K, Pradhan V
Epstein-Barr viral infection is one of the known environmental factors involved in development of Systemic Lupus Erythematous (SLE). Though not much is known about the exact role of EBV in SLE pathogenesis, the theory of switching of lytic and lysogenic cycles of Epstein-Barr virus in memory B-cells fits well with the periods of waning disease activity and intermittent flares in SLE patients. In this study, we investigate the association of EBV antibody profile with clinical and serological parameters in SLE...
July 22, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28710863/assessment-of-the-effectiveness-of-hpv16-18-infection-referred-for-colposcopy-in-cervical-cancer-screening-in-northwest-of-china
#14
Qian Zhang, Minyi Zhao, Di Cao, Xing Wei, Li Wang, Yang Li, Ting Yang, Juan Zhao, Meili Pei, Hongran Jia, Siyu Cao, Shimin Quan, Xiaofeng Yang
OBJECTIVE: To evaluate the effectiveness of HPV16/18 infection referral to colposcopy in cervical cancer screening for women aged 25 years and older in Chinese northwest region Shaan'xi province. METHODS: 2224 women were diagnosed with primary high-risk HPV infection by HPV-DNA genotyping technology during August 2014 to August 2015. 1916 cases referred for colposcopy with histological evidence were enrolled, including 1124 women with HPV16/18 genotype and 792 with other HR-HPV genotypes...
July 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28710858/identification-of-group-b-rotavirus-as-an-etiological-agent-in-the-gastroenteritis-outbreak-in-maharashtra-india
#15
Madhuri S Joshi, Nital N Ganorkar, Sujata S Ranshing, Atanu Basu, Nutan A Chavan, Varanasi Gopalkrishna
Acute gastroenteritis outbreak occurred at Pargaon, Maharashtra, India in 1789 cases with an attack rate of 32.5% between November to December 2015. The stool specimens (n = 32) were investigated for different enteric viral agents using conventional methods. Transmission electron microscopy and RNA polyacrylamide gel electrophoresis respectively identified morphologically distinct rotavirus particles in 28% and RNA migration pattern of Group B Rotavirus (GBR) in 72% of the specimens. Reverse transcription polymerase chain reaction and nucleotide sequencing confirmed presence of GBR in 97% of the samples analyzed...
July 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28710853/real-world-effectiveness-of-sofosbuvir-based-treatment-regimens-for-chronic-hepatitis-c-genotype-3-infection-results-from-the-multicenter-german-hepatitis-c-cohort-gecco-03
#16
Malte H Wehmeyer, Patrick Ingiliz, Stefan Christensen, Dietrich Hueppe, Thomas Lutz, Karl Georg Simon, Knud Schewe, Christoph Boesecke, Axel Baumgarten, Heiner Busch, Juergen Rockstroh, Guenther Schmutz, Torben Kimhofer, Florian Berger, Stefan Mauss, Julian Schulze Zur Wiesch
There are limited data regarding the real world effectiveness of direct acting antivirals (DAA) for the therapy of chronic genotype 3 hepatitis C virus (HCV) infection. All HCV genotype 3 infected patients from the German hepatitis C cohort (GECCO), which is a prospective database of nine German hepatitis C treatment centers, were included in the study. 342 chronically infected HCV genotype 3 patients were analyzed (253 males [74.0%], mean age 47.3 years, 127 cirrhotic patients [37.1%] mostly with Child A cirrhosis, 113 treatment experienced patients [37...
July 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28700089/prevalence-and-genotype-distribution-of-human-papillomavirus-among-females-in-the-suburb-of-shanghai-china
#17
Chengzhong Zhang, Chao Zhang, Jie Huang, Zhouwei Wu, Xingyu Mei, Weimin Shi
OBJECTIVES: To describe the prevalence of human papillomavirus (HPV) and its genotype distribution among females in the suburb of Shanghai. METHODS: A total of 33,562 participants were enrolled in this study from January to December 2016. HPV GenoArray test kit was used to perform HPV genotyping and was also used in DNA amplification and HybriBio's proprietary flow-through hybridization technique. RESULTS: The overall prevalence of HPV was 18...
July 12, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28700085/characterization-of-clinical-predictors-of-naturally-occurring-ns3-ns4a-protease-polymorphism-in-genotype-1-hepatitis-c-virus-mono-and-hiv-co-infected-patients
#18
Gaspar Lisboa Neto, F M Malta, Michele S Gomes-Gouvêa, Caroline F Noble, C M Romano, J R Pinho, Mariliza H da Silva, Andrea Gb Leite, Leonora Z Piccoli, F J Carrilho, M C Mendes-Correa
Spontaneously occurring resistance may impair the success of protease inhibitors based regimens in HCV treatment. This study aimed to evaluate associations between amino acid substitutions in NS3/NS4A domain and clinical features of 247 HCV mono or HCV/HIV co-infected patients. Fourteen samples (5.7%) harbored at least one resistance-associated substitution (RAS). The following RASs were detected in NS3 region: T54S (6 - 2.4%), V55A (7 - 2.8%) and Q80R (2 - 0.8%). S122G occurred in 86.9% of HCV genotype 1b samples with either natural polymorphisms or RASs...
July 12, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28700080/anal-hpv-16-and-18-viral-load-a-comparison-between-hiv-negative-and-hiv-positive-msm-and-association-with-persistence
#19
Elske Marra, Audrey King, Elske van Logchem, Pascal van der Weele, Sofie H Mooij, Titia Heijman, Chris J L M Meijer, Dominique W M Verhagen, Marianne A B van der Sande, Maarten F Schim van der Loeff
Objective Does anal HPV viral load explain the difference in anal HPV persistence between HIV-negative and HIV-positive men who have sex with men (MSM)? Methods MSM ≥18 years were recruited in Amsterdam, the Netherlands, in 2010-2011. Anal self-swabs were collected every 6 months and genotyped (SPF10 -PCR-DEIA-LIPA25 -system). HPV16 and HPV18 load was determined with a type specific quantitative (q)PCR, and compared between HIV-negative and HIV-positive men using ranksum test. Persistence was defined as ≥3 positive samples for the same HPV-type...
July 12, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28688190/improvement-of-glycemic-state-among-responders-to-sofosbuvir-based-treatment-regimens-single-center-experience
#20
Shereen Abdel Alem, Aisha Elsharkawy, Rabab Fouad, Eman Adel, Zeinab Abdellatif, Sherief Musa, Ahmed Nagy, Muhammad S Hussein, Ayman Yosry, Gamal Esmat
BACKGROUND: Chronic HCV infection has emerged as a complex multifaceted disease with manifestations extending beyond the liver. HCV plays a direct role in glucose metabolism leading to both insulin resistance and type 2 diabetes. AIMS: To evaluate the changes in the glycemic state following Sofosbuvir-based treatment regimens in diabetic HCV patients. METHODS: Four hundred chronic hepatitis C patients who underwent Sofosbuvir-based treatment regimens were retrospectively screened...
July 8, 2017: Journal of Medical Virology
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