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Journal of Medical Virology

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https://www.readbyqxmd.com/read/28734074/association-of-clinical-and-serological-parameters-of-systemic-lupus-erythematosus-patients-with-epstein-barr-virus-antibody-profile
#1
Chougule D, Nadkar M, Rajadhyaksha A, Pandit P, Surve P, Dawkar N, Khadilkar P, Patwardhan M, Kaveri Sv, Ghosh K, Pradhan V
Epstein-Barr viral infection is one of the known environmental factors involved in development of Systemic Lupus Erythematous (SLE). Though not much is known about the exact role of EBV in SLE pathogenesis, the theory of switching of lytic and lysogenic cycles of Epstein-Barr virus in memory B-cells fits well with the periods of waning disease activity and intermittent flares in SLE patients. In this study, we investigate the association of EBV antibody profile with clinical and serological parameters in SLE...
July 22, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28710863/assessment-of-the-effectiveness-of-hpv16-18-infection-referred-for-colposcopy-in-cervical-cancer-screening-in-northwest-of-china
#2
Qian Zhang, Minyi Zhao, Di Cao, Xing Wei, Li Wang, Yang Li, Ting Yang, Juan Zhao, Meili Pei, Hongran Jia, Siyu Cao, Shimin Quan, Xiaofeng Yang
OBJECTIVE: To evaluate the effectiveness of HPV16/18 infection referral to colposcopy in cervical cancer screening for women aged 25 years and older in Chinese northwest region Shaan'xi province. METHODS: 2224 women were diagnosed with primary high-risk HPV infection by HPV-DNA genotyping technology during August 2014 to August 2015. 1916 cases referred for colposcopy with histological evidence were enrolled, including 1124 women with HPV16/18 genotype and 792 with other HR-HPV genotypes...
July 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28710858/identification-of-group-b-rotavirus-as-an-etiological-agent-in-the-gastroenteritis-outbreak-in-maharashtra-india
#3
M S Joshi, N N Ganorkar, S S Ranshing, A Basu, N A Chavan, V Gopalkrishna
Acute gastroenteritis outbreak occurred at Pargaon, Maharashtra, India in 1789 cases with an attack rate of 32.5% between November to December 2015. The stool specimens (n = 32) were investigated for different enteric viral agents using conventional methods. Transmission electron microscopy and RNA polyacrylamide gel electrophoresis respectively identified morphologically distinct rotavirus particles in 28% and RNA migration pattern of Group B Rotavirus (GBR) in 72% of the specimens. Reverse transcription polymerase chain reaction and nucleotide sequencing confirmed presence of GBR in 97% of the samples analyzed...
July 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28710853/real-world-effectiveness-of-sofosbuvir-based-treatment-regimens-for-chronic-hepatitis-c-genotype-3-infection-results-from-the-multicenter-german-hepatitis-c-cohort-gecco-03
#4
Malte H Wehmeyer, Patrick Ingiliz, Stefan Christensen, Dietrich Hueppe, Thomas Lutz, Karl Georg Simon, Knud Schewe, Christoph Boesecke, Axel Baumgarten, Heiner Busch, Juergen Rockstroh, Guenther Schmutz, Torben Kimhofer, Florian Berger, Stefan Mauss, Julian Schulze Zur Wiesch
There are limited data regarding the real world effectiveness of direct acting antivirals (DAA) for the therapy of chronic genotype 3 hepatitis C virus (HCV) infection. All HCV genotype 3 infected patients from the German hepatitis C cohort (GECCO), which is a prospective database of nine German hepatitis C treatment centers, were included in the study. 342 chronically infected HCV genotype 3 patients were analyzed (253 males [74.0%], mean age 47.3 years, 127 cirrhotic patients [37.1%] mostly with Child A cirrhosis, 113 treatment experienced patients [37...
July 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28700089/prevalence-and-genotype-distribution-of-human-papillomavirus-among-females-in-the-suburb-of-shanghai-china
#5
Chengzhong Zhang, Chao Zhang, Jie Huang, Zhouwei Wu, Xingyu Mei, Weimin Shi
OBJECTIVES: To describe the prevalence of human papillomavirus (HPV) and its genotype distribution among females in the suburb of Shanghai. METHODS: A total of 33,562 participants were enrolled in this study from January to December 2016. HPV GenoArray test kit was used to perform HPV genotyping and was also used in DNA amplification and HybriBio's proprietary flow-through hybridization technique. RESULTS: The overall prevalence of HPV was 18...
July 12, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28700085/characterization-of-clinical-predictors-of-naturally-occurring-ns3-ns4a-protease-polymorphism-in-genotype-1-hepatitis-c-virus-mono-and-hiv-co-infected-patients
#6
Gaspar Lisboa Neto, Fernanda M Malta, Michele S Gomes-Gouvêa, Caroline F Noble, Camila Malta Romano, João Renato R Pinho, Mariliza H da Silva, Andrea Gb Leite, Leonora Z Piccoli, Flair J Carrilho, Maria Cássia Mendes-Correa
Spontaneously occurring resistance may impair the success of protease inhibitors based regimens in HCV treatment. This study aimed to evaluate associations between amino acid substitutions in NS3/NS4A domain and clinical features of 247 HCV mono or HCV/HIV co-infected patients. Fourteen samples (5.7%) harbored at least one resistance-associated substitution (RAS). The following RASs were detected in NS3 region: T54S (6 - 2.4%), V55A (7 - 2.8%) and Q80R (2 - 0.8%). S122G occurred in 86.9% of HCV genotype 1b samples with either natural polymorphisms or RASs...
July 12, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28700080/anal-hpv-16-and-18-viral-load-a-comparison-between-hiv-negative-and-hiv-positive-msm-and-association-with-persistence
#7
Elske Marra, Audrey King, Elske van Logchem, Pascal van der Weele, Sofie H Mooij, Titia Heijman, Chris J L M Meijer, Dominique W M Verhagen, Marianne A B van der Sande, Maarten F Schim van der Loeff
Objective Does anal HPV viral load explain the difference in anal HPV persistence between HIV-negative and HIV-positive men who have sex with men (MSM)? Methods MSM ≥18 years were recruited in Amsterdam, the Netherlands, in 2010-2011. Anal self-swabs were collected every 6 months and genotyped (SPF10 -PCR-DEIA-LIPA25 -system). HPV16 and HPV18 load was determined with a type specific quantitative (q)PCR, and compared between HIV-negative and HIV-positive men using ranksum test. Persistence was defined as ≥3 positive samples for the same HPV-type...
July 12, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28688190/improvement-of-glycemic-state-among-responders-to-sofosbuvir-based-treatment-regimens-single-center-experience
#8
Shereen Abdel Alem, Aisha Elsharkawy, Rabab Fouad, Eman Adel, Zeinab Abdellatif, Sherief Musa, Ahmed Nagy, Muhammad S Hussein, Ayman Yosry, Gamal Esmat
BACKGROUND: Chronic HCV infection has emerged as a complex multifaceted disease with manifestations extending beyond the liver. HCV plays a direct role in glucose metabolism leading to both insulin resistance and type 2 diabetes. AIMS: To evaluate the changes in the glycemic state following Sofosbuvir-based treatment regimens in diabetic HCV patients. METHODS: Four hundred chronic hepatitis C patients who underwent Sofosbuvir-based treatment regimens were retrospectively screened...
July 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28681977/detection-and-quantification-of-merkel-cell-polyomavirus-analysis-of-merkel-cell-carcinoma-cases-from-1977-to-2015
#9
Marta E Álvarez-Argüelles, Santiago Melón, Susana Rojo, Ana Fernandez-Blázquez, Jose Antonio Boga, Ana Palacio, Blanca Vivanco, María de Oña
BACKGROUND: This study investigates the presence of Merkel cell polyomavirus (MCPyV) in skin lesions of patients with Merkel cell carcinoma (MCC). METHODS: MCPyV was quantified using quantitative Real-Time-PCR (qRT-PCR) in 34 paraffinized MCC samples (resected/biopsied) originally taken between 1977 and 2015, and 6 non-MCC samples. RESULTS: In 31 (91.2%) MCC-individuals, MCPyV was detected. No virus was observed in any non-MCC tumour. Average age at diagnosis was 78...
July 6, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28671305/younger-trend-of-cirrhosis-incidence-in-genotype-3-hcv-infected-patients-in-eastern-china
#10
Jie Lu, Xiaogang Xiang, Zhujun Cao, Weijing Wang, Gangde Zhao, Weiliang Tang, Lu Chen, Simin Guo, Yan Zhuang, Dongmei Shi, Lichang Chen, Shisan Bao, Wei Cai, Hui Wang, Huijuan Zhou, Qing Xie
The diversity of HCV genotypes is ever-evolving and requires continuous surveillance. The aim of this study was to investigate the dynamics of HCV genotypes, and their associated demographic and clinical patterns in China. By searching computerized hospital information system, a total of 1,155 HCV-positive patients eligible for analysis were retrospectively identified from 12,380 consecutive in-patients in the Department of Infectious Diseases, Ruijin Hospital in China between 2009 and 2014. The percentages of HCV genotype 1, 2, 3 or 6 were 61...
July 3, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28671301/detection-of-long-term-cellular-immune-response-to-japanese-encephalitis-vaccination-using-ifn-%C3%AE-elispot-assay
#11
Amreen Zia, Dharamveer Singh, Swati Saxena, Jyoti Umrao, Manjari Baluni, Sneha Ghildiyal, Tanzeem Fatima, Mukti Shukla, Vikas Agarwal, Tapan N Dhole
Vaccine is the most effective preventive measure against Japanese Encephalitis infection. Role of IFN-γ expressing T cells for JE virus clearance has been described as a part of cellular immunity. Vaccine induced immunity also involve the cellular immune response, therefore the study was aimed to observe induction and persistence of IFN-γ expressing T cells by IFN-γ ELISpot assay. The cell count increased significantly after 28 (p < 0.0001) days post vaccination, and remained higher at all time points (day 28, day 180, day 360) when compared with prevaccination...
July 3, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28671295/characterization-of-the-nasopharyngeal-viral-microbiome-from-children-with-community-acquired-pneumonia-but-negative-for-luminex-xtag-respiratory-viral-panel-assay-detection
#12
Lili Xu, Yun Zhu, Lili Ren, Baoping Xu, Chunyan Liu, Zhengde Xie, Kunling Shen
In the present study, 50 nasopharyngeal swabs from children with community-acquired pneumonia (CAP) but negative for 18 common respiratory viruses, as measured by the Luminex xTAG Respiratory Viral Panel Assay, were subjected to multiplex metagenomic analyses using a next-generation sequencing platform. Taxonomic analysis showed that all sequence reads could be assigned to a specific species. An average of 95.13% were assigned to the Bacteria kingdom, whereas only 0.72% were potentially virus derived. This snapshot of the respiratory tract virome revealed most viral reads to be respiratory tract related, classified into four known virus families: Paramyxoviridae, Herpesviridae, Anelloviridae, and Polyomaviridae...
July 3, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28667764/human-polyomavirus-9-in-immunocompromised-patients-in-the-university-hospital-in-hradec-kralove-czech-republic
#13
Fajfr Miroslav, Pliskova Lenka, Kutova Radka, Matyskova-Kubisova Michaela, Navratil Pavel, Radocha Jakub, Valenta Zbynek, Dusilova-Sulkova Sylvie
INTRODUCTION: Human polyomaviruses such as JC polyomavirus and BK polyomavirus have long been well known pathogens of immunocompromised patients. Several new members of this viral family have been described during the last decade. Human polyomavirus 9 seems to be a novel pathogen of transplanted patients according to some studies. The study aim: The aim of our study was to determine the presence of human polyomavirus 9 in patients after kidney or stem cell transplantation at the University Hospital in Hradec Kralove, Czech Republic...
July 1, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28667756/prognosis-and-predictors-of-hepatocellular-carcinoma-in-elderly-patients-infected-with-hepatitis-b-virus
#14
Mitsutaka Osawa, Norio Akuta, Fumitaka Suzuki, Shunichiro Fujiyama, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Yoshiyuki Suzuki, Kenji Ikeda, Hiromitsu Kumada
With rapidly aging population in the world, many elderly patients present with hepatitis B virus (HBV) infection. We conducted a retrospective cohort study involving 359 untreated HBV patients aged 60 and older who were free of HCC and acute hepatitis at the initial visit, and examined the incidence of hepatocellular carcinoma (HCC) and liver-related mortality rate. During the follow-up period of 7.9 years (range, 0-25 years), 26 patients (7.2% of patients) developed HCC, 20 patients died from liver-related diseases (61% of total deaths), including HCC, liver failure, and gastrointestinal bleeding...
July 1, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28667755/incidence-and-risk-factors-for-human-papillomavirus-infections-in-young-female-online-daters
#15
Sharon Ma, Joshua E Stern, Qinghua Feng, James P Hughes, Stephen E Hawes, Rachel L Winer
Risk factors for incident HPV infections are undefined in young women who use internet dating Web sites. From 2010-2012 we followed 18-24-year-old female internet daters (N = 164) triannually for a mean of one year. Women collected and returned self-collected vaginal samples for HPV genotyping and health and behavior questionnaires. We used Kaplan-Meier methods to estimate incidence of clinically-relevant HPV infection (high-risk HPV, HPV-6, or HPV-11) and generalized estimating equations and Firth logistic regression to identify associated risk factors...
July 1, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28661055/evaluation-the-architect-ebv-vca-igm-vca-igg-and-ebna-1-igg-chemiluminescent-immunoassays-to-assess-ebv-serostatus-prior-transplantation
#16
Sarah Maylin, Linda Feghoul, Maud Salmona, Adel Herda, Séverine Mercier-Delarue, François Simon, Jérôme Legoff
Prior to transplantation of hematopoietic stem cells or solid organ, donor and recipient EBV serostatus has to be determined to assess risks of post-transplant lymphoproliferative disorders. Sensitivity of EBV Viral capsid antigens (VCA) IgG and EBV nuclear antigen-1 (EBNA-1) is critical to define past infection and a good specificity of VCA IgM is required to avoid any disqualification of cord blood (CB) units. Architect™ EBV antibody panel (Architect assay) providing a high throughput was compared to a semi-automated ELISA (Etimax assays Diasorin) to assess sensitivities and specificities of VCA and EBNA-1 IgG and VCA IgM on 419 sera collected from immunocompromised patients (n=184) and from pregnant women who agreed to give CB cells (n=235)...
June 29, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28661048/prevalence-of-human-papillomavirus-infection-in-women-in-the-autonomous-region-of-inner-mongolia-a-population-based-study-of-a-chinese-ethnic-minority
#17
Xiao Hua Wang, Yun Peng Ji, Juan Li, Hong Dong, Bo Zhu, Yan Zhou, Jie Wang, Xue Yuan Zhou, Yan Wang, Maikel P Peppelenbosch, Qiuwei Pan, Xiao Ping Ji, Dong Jun Liu
PURPOSE: Human papillomavirus (HPV) is one of the most common sexually transmitted infectious pathogens. Persistent infection has been linked to cancerdevelopment, in particular to cervical cancer. This study aims to investigate the epidemiology of HPV infection in women in Inner Mongolia of China and to dissect the disparities between the Han and Mongolian ethnic populations. METHODS: Cervical cell samples from 5655 women (17-68 years old) were collected during routine gynecologic examination...
June 29, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28661003/no-detection-of-merkel-cell-polyomavirus-in-oral-lichen-planus-results-of-a-preliminary-study-in-a-french-cohort-of-patients
#18
M Masson Regnault, E Vigarios, F Projetti, B Herbault-Barres, E Tournier, L Lamant, V Sibaud
Oral lichen planus (OLP) is a chronic inflammatory disease considered as a CD8+ T lymphocyte-mediated autoimmune reaction, which may be triggered by undetermined virus. Recent reports have described the detection of Merkel Cell polyomavirus (MCPyV) DNA in oral samples from healthy patients and in patients withdifferent forms of oral cancers. We therefore investigated in a prospective way whether MCPyV was detectable in oral lesions of patients with active OLP. Our preliminary results do not support the hypothesis that OLP may be triggered by MCPyV infection...
June 29, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28657148/association-between-mitochondrial-dna-content-and-baseline-serum-levels-of-hbsag-in-chronic-hepatitis-b-infection
#19
Tianbin Chen, Zhen Xun, Jinpiao Lin, Ya Fu, Wennan Wu, Xiaochun Fu, Yuhai Hu, Yongbin Zeng, Qishui Ou
Recent studies have demonstrated a potential link between mitochondrial DNA (mtDNA) content and cirrhosis or hepatocellular carcinoma (HCC). However, there are few studies evaluating mtDNA content as a noninvasive marker of chronic hepatitis B infection (CHB). In this study, we conducted a case-control study to determine mtDNA content in peripheral blood leukocyte (PBL) samples from 76 CHB cases naïve to antivirus therapy and 96 healthy controls, and then evaluated the association between mtDNA content and baseline serum concentration of HBV markers...
June 28, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28657143/emergence-of-drug-resistance-associated-variants-and-changes-in-serum-lipid-profiles-in-sofosbuvir-plus-ledipasvir-treated-chronic-hepatitis-c-patients
#20
Hiromi Kan, Michio Imamura, Yoshiiku Kawakami, Kana Daijo, Yuji Teraoka, Fumi Honda, Yuki Nakamura, Kei Morio, Tomoki Kobayashi, Takashi Nakahara, Yuko Nagaoki, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, Hiroshi Aikata, C Nelson Hayes, Daiki Miki, Hidenori Ochi, Yoji Honda, Nami Mori, Shintaro Takaki, Keiji Tsuji, Kazuaki Chayama
Combination of sofosbuvir plus ledipasvir therapy has been expected to enhance sustained virological response (SVR) rates in hepatitis C virus (HCV) genotype 1 chronic infected patients. We analyzed the emergence of drug resistance-associated variants (RAVs) in treatment failure and changes in lipid profiles in sofosbuvir/ledipasvir-treated patients. 176 patients with chronic HCV genotype 1 infection without decompensated liver cirrhosis were treated with sofosbuvir/ledipasvir for 12 weeks. NS5A and NS5B RAVs were determined by either Invader assay or direct sequencing...
June 28, 2017: Journal of Medical Virology
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