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Journal of Medical Virology

Tonia C Carter, Scott J Hebbring, Jixia Liu, Jonathan D Mosley, Christian M Shaffer, Lynn C Ivacic, Sarah Kopitzke, Elisha L Stefanski, Rob Strenn, Maria E Sundaram, Jennifer Meece, Murray H Brilliant, Jill M Ferdinands, Edward A Belongia
Host response to influenza is highly variable, suggesting a potential role of host genetic variation. To investigate the host genetics of severe influenza in a targeted fashion, 32 single nucleotide polymorphisms (SNPs) within viral immune response genes were evaluated for association with seasonal influenza hospitalization in an adult study population with European ancestry. SNP allele and genotype frequencies were compared between hospitalized influenza patients (cases) and population controls in a case-control study that included a discovery group (26 cases and 993 controls) and two independent, validation groups (one with 84 cases and 4,076 controls; the other with 128 cases and 9,187 controls)...
October 20, 2017: Journal of Medical Virology
Yuying Liang, Xin Jin, Yuan Huang, Shuiping Chen
BACKGROUND: crAssphage is a novel and by far the most abundant bacteriophage in human gut. This bacteriophage might modulate gut microbiota balance so as to be involved in some diseases like obesity, diabetes, metabolic disorders, hypertension, and cancer. Therefore, a rapid and reliable detection and quantification method for crAssphage is essential for studying its molecular epidemiology and pathogenicity in human diseases. MATERIALS AND METHODS: The primers-probes set for the quantitative real-time PCR assay was designed based on the DNA polymerase gene (ORF00018) of crAssphage...
October 16, 2017: Journal of Medical Virology
Kevin Messacar, Mark J Abzug, Samuel R Dominguez
No abstract text is available yet for this article.
October 12, 2017: Journal of Medical Virology
Bita Javan, Mohamad Reza Kalani, Majid Shahbazi
Hepatitis B virus (HBV) infection is well known as an important cause of the chronic liver disease. The screening of the genotype of certain cytokines might be helpful to predict the clinical outcome of an HBV infection. The present study investigates the relationship between the polymorphism and haplotypes of the Interleukin-1 (IL-1) gene family, including IL-1-alpha (IL-1A), IL-1-beta (IL-1B) and IL-1 receptor antagonist (IL-1RN), with chronic HBV infection. 297 chronic HBV and 333 matched on sex and age control individuals were genotyped using the standard sequence-specific- polymerase chain reaction primer (SSP-PCR) method...
October 11, 2017: Journal of Medical Virology
Rajaa M Al-Raddadi, Noha A Dashash, Hani A Alghamdi, Zeyad M Al-Raddadi, Hanan S Alzahrani, Abdullah J Alsahafi, Abdullah M Algarni, Majed M Alghamdi, Raghad F Hakim, Abdulmohsen H Al-Zalabani, Fanar Hakim, Feras Ayman Moria
BACKGROUND: The infection rate of the hepatitis C virus (HCV) in Saudi Arabia is among the lowest in the world. However, it is likely that poor knowledge and awareness of HCV infection could minimize the effectiveness of prevention and control programs in the kingdom. OBJECTIVES: Thus, the study objective was to estimate the prevalence of HCV infection, and to assess current knowledge about it, in the targeted population. METHODS: Data on 5482 Saudi people attending primary healthcare centers in Jeddah City in 2014/2015 were analyzed in this cross-sectional study...
October 11, 2017: Journal of Medical Virology
Itziar Carrasco, Ana Arias, Laura Benítez-Gutiérrez, Gema Lledó, Silvia Requena, Miriam Cuesta, Valentín Cuervas-Mons, Carmen de Mendoza
BACKGROUND: Oral DAA have demonstrated high efficacy as treatment of hepatitis C. However, the presence of resistance-associated substitutions (RAS) at baseline has occasionally been associated with impaired treatment response. Herein, we examined the impact of baseline RAS at the HCV NS5A gene region on treatment response in a real-life setting. METHODS: All hepatitis C patients treated with DAA including NS5A inhibitors at our institution were retrospectively examined...
October 9, 2017: Journal of Medical Virology
Si-Qing Liu, Xiao Li, Cheng-Lin Deng, Zhi-Ming Yuan, Bo Zhang
Zika virus (ZIKV) and chikungunya virus (CHIKV) are important human pathogens and mosquito-borne arboviruses, which have resembling history, common vectors, circulating regions, and indistinguishable clinical symptoms. Wide geographical range that is suitable for ZIKV and CHIKV transmission underlines the concern about the impact of epidemic and endemic infections on burden of public health. In the present study, a highly sensitive and specific one-step multiplex real-time RT-PCR assay was developed and evaluated for simultaneous detection and quantification of ZIKV and CHIKV...
October 5, 2017: Journal of Medical Virology
Marc Steben, Najwa Ouhoummane, Caroline Rodier, Liliya Sinyavskaya, Paul Brassard
BACKGROUND: In Québec, Canada, a public school-based and catch-up HPV vaccination programs with the quadrivalent vaccine have been introduced in September 2008 for girls aged 9-17 years. We assessed the early impact of the HPV vaccination program on the incidence of anogenital warts (AGW) in the Quebec general population. METHODS: We used the provincial health administrative data of the Régie de l'assurance maladie du Québec (RAMQ). AGW were identified either through a prescription of podofilox, or a medical procedure code specific to AGW, or a diagnostic code for viral warts followed by a prescription of imiquimod or fluorouracil...
October 5, 2017: Journal of Medical Virology
Leyda E Ábrego, Santiago Mirazo, Adriana Delfraro, Danilo Franco, Marlene Castillo, Melissa Gaitán, Juan Castillo, Brechla Moreno, Juan M Pascale, Juan Arbiza
Human metapneumovirus (HMPV) is a common causative agent of severe respiratory tract infections in children under 5 years old, the elderly and immunocompromised patients, being responsible for 5-15% of all viral respiratory infections requiring hospitalization. Though HMPV was included in the surveillance program for respiratory viruses in 2010, its genotype distribution remains unknown. Herein, 45 positive samples to HMPV from children ≤5 years old were characterized by phylogenetic analysis based on N gene sequence...
October 5, 2017: Journal of Medical Virology
S Cordey, G Vieille, L Turin, L Kaiser
In 2009, the Usutu virus (USUV) was first reported as a cause of human neuroinvasive disorders. In Switzerland, USUV has been detected in wild birds with a seroprevalence of up to 6.59% in captive specimens sampled from zoo enclosures. This study investigates the clinical prevalence of USUV in human acute neuroinvasive disorders in Switzerland. Two hundred fifty-eight cerebrospinal fluid samples collected between 2015 and 2017 for routine clinical care in a tertiary level hospital (Geneva) were tested for USUV by rRT-PCR...
October 4, 2017: Journal of Medical Virology
Cristina Fevola, Suvi Kuivanen, Teemu Smura, Antti Vaheri, Hannimari Kallio-Kokko, Heidi C Hauffe, Olli Vapalahti, Anne J Jääskeläinen
BACKGROUND: Directly-transmitted rodent-borne zoonotic viruses, such as lymphocytic choriomeningitis virus (LCMV) can cause nervous system infections. Rodent-borne Ljungan virus (LV) is considered potentially zoonotic possibly causing neurological symptoms. Our objective was to understand the role of these two viruses compared to other pathogens in causing neurological infections in Finnish patients. METHODS: Routine screening data were available for 400 patients aged 5-50 years, collected from December 2013-December 2014 with suspected neurological infection...
October 4, 2017: Journal of Medical Virology
Yukai Huang, Jun Hua, Dan Wang, Liling Chen, Jun Zhang, Hong Zhu, Jianmei Tian, Tao Zhang, Genming Zhao
Background The characteristics and risk factors of respiratory syncytial virus (RSV) infection among children has not yet been fully understood. Objectives To address the characteristics of RSV-associated illness and risk factors of RSV infection among children under 5 years of age in Suzhou, China. Methods From April 2011 to March 2014, we conducted a prospective surveillance among children in Suzhou, China. Nasal or throat swabs were collected from outpatients with influenza-like illness (ILI) and inpatients with severe acute respiratory infections (SARI)...
October 3, 2017: Journal of Medical Virology
Naglaa F Alsalawy, Rania K Darwish, Manal M Kamal, Ahmed E ElTaweel, Hend I Shousha, Tamer M Elbaz
Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) plays an important role in many cancers including hepatocellular carcinoma (HCC). The aim of this study is to investigate the association of the DR4 polymorphisms C626G (Thr209Arg, rs20575) and A683C (Glu228Ala, rs20576) with the occurrence of HCC in Egyptian patients chronically infected with HCV. The study included 80 patients with HCV-related HCC (group 1) and 80 patients with HCV-related liver cirrhosis (group 2) who are naïve to treatment...
October 3, 2017: Journal of Medical Virology
Tao Peng, Tingting Xie, Lei Liu, Junhui Zhen, Xiangdong Yang
Objective To analyze the relationship between the factors related to the occurrence of HBV-GN and serum HBsAg-positive glomerulonephritis. Methods A total of fifty-six patients were enrolled in the present study. All enrolled cases were divided into two groups according to whether HBsAg and/or HBcAg was present in renal kidney tissue: patients with Hepatitis B virus-associated nephritis (HBV-GN group, 30 cases) and patients with hepatitis B virus-combined nephritis (HBV-CG group, 26 cases). We sought to analyse the differences in clinical features and pathological characteristics in both groups...
October 3, 2017: Journal of Medical Virology
Zhenqiu Liu, Qiwen Fang, Jialu Zuo, Yue Chen, Veenu Minhas, Charles Wood, Tiejun Zhang
Men who have sex with men (MSM) were highly vulnerable to HIV/AIDS and Human herpes virus 8 (HHV8), while the epidemiologic features of HHV8 among MSM remain obscure. We therefore performed a systematic review and meta-analysis to assess the burden of HHV8 in MSM. Electronic databases were searched for publications on HHV8 epidemiologic characteristics among MSM. Random-effect meta-analysis was applied to combine the HHV8 seroprevalence in MSM and odds ratios (ORs) for associated risk factors. Meta-regression and stratified analyses were performed to detect the potential sources of heterogeneity...
October 3, 2017: Journal of Medical Virology
Johanna Mäki, Henrik Paavilainen, Katja Kero, Veijo Hukkanen, Stina Syrjänen
Herpes simplex virus (HSV) establishes latency in neurons and recurrent infections in oral mucosa. This prospective study analyzes HSV prevalence in oral mucosal brush samples from men with known human papillomavirus (HPV) status. We hypothesized that HSV-1-infection could facilitate HPV persistence as a cofactor. This study was a part of the Finnish Family HPV study accomplished at the University of Turku/Turku University Hospital, Finland. A total of 139 men (mean age 28.6 ± 4.9 years) were enrolled at 36+-weeks of their partner's pregnancy and thereafter followed-up for 6 years...
October 3, 2017: Journal of Medical Virology
Oumei Hao, Xuefeng Wang, Jianping Liu, Kunling Shen, Rong Ma, Zhenze Cui, Li Deng, Huimin Yan, Lining Wang, Zhaolan Liu, Xinmin Li, Hua Xu, Zhiyan Jiang, Yanning Li, Yan Huang, Baoqing Zhang, Xiaochun Feng, Chunhui He, Yonghong Jiang, Xue Zhao, Wei Wei, Zi Wang
Childhood community-acquired pneumonia (CAP) is a common illness; however, comprehensive studies of hospitalizations for CAP among children in China based on prospective and multicenter data collection are limited. The aim of this investigation was to determine the respiratory pathogens responsible for CAP in hospitalized children. From January to December 2015, oropharyngeal swabs and blood serum were collected from hospitalized children with CAP symptoms ranging in age from 6 months to 14 years at 10 hospitals across China...
October 3, 2017: Journal of Medical Virology
Carlos E Rodríguez-Martínez, Ranniery Acuña-Cordero, Monica P Sossa-Briceño
BACKGROUND: Length of hospital stay and readmissions are outcome measures that have been largely overlooked in many studies that have evaluated the clinical evolution of pediatric patients with bronchopulmonary dysplasia (BPD). The aim of the present study was to identify predictors of prolonged hospitalizations or readmissions for acute lower respiratory infections (ALRIs) in infants with BPD. METHODS: In a prospective cohort study, we determined independent predictors of prolonged hospitalizations or readmissions for ALRIs during the first two years of life in a population of infants with BPD living in Bogota, Colombia...
October 3, 2017: Journal of Medical Virology
Simon Grandjean Lapierre, Karel Boissinot, Christian Renaud
This study compared the Altona RealStar™ VZV Kit 1.0 real time quantitative VZV PCR with in house qualitative conventional VZV PCR on cerebrospinal fluid, mucocutaneous and other uncommon clinical specimens. Overall rates of agreement, positive, and negative percent agreements were respectively 97.9% (95% CI: 93.8-99.6), 100.0% (95% CI: 93.1-100.0) and 96.3% (95% CI: 89.4-99.2) while Cohen's kappa statistic value was 0.96 (95% CI: 0.91-1.00). RealStar™ VZV quantitative PCR assay reported average quantitative viral loads of 4...
October 2, 2017: Journal of Medical Virology
Edina Amponsah-Dacosta, Selokela G Selabe, M Jeffrey Mphahlele
BACKGROUND: We investigated how the natural course of occult hepatitis B virus (HBV) infection (OBI) may evolve during HIV co-infection and long term HBV-active HAART. METHODS: From a cohort of 181 HIV infected patients who were consecutively recruited over a 5 year period, 28 HBV co-infected patients with sequential sera (n = 98) were identified. Iterative HBV serology and viral loads were determined before and during treatment. The viral HBsAg gene was then serially amplified, directly sequenced and molecularly characterized...
October 2, 2017: Journal of Medical Virology
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