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Journal of Medical Virology

Burcu Bayyurt, Serdal Arslan, Aynur Engin, Mehmet Bakir
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease caused by the Crimean-Congo hemorrhagic fever virus (CCHFV). Long non-coding RNAs (lncRNAs) are generally classified as transcripts longer than 200 nucleotides (nt). The various lncRNAs expressed in infected cells are responsible for regulating the expression of viral and host genes. This is the first study to investigate hepatocellular carcinoma up-regulated long non-coding RNA (HULC) and 7SL RNA expression levels in CCHF patients. Blood samples were taken from 100 individuals (60 patients and 40 controls) and total RNA isolation was performed...
July 17, 2018: Journal of Medical Virology
Hajar Chihab, Fatima-Zahra Jadid, Pelagia Foka, Imane Zaidane, Raouia El Fihry, Urania Georgopoulou, Agnes Marchio, Abdellah Elhabazi, Mohammed Chair, Pascal Pineau, Sayeh Ezzikouri, Soumaya Benjelloun
Hepatitis B virus (HBV) -specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death-1 (PD-1), an immunosuppressive molecule that regulates T cell activation and peripheral immune tolerance, is increasingly shown to influence the outcome of HBV infection. rs10204525, a single-nucleotide polymorphism (SNP) in the 3' untranslated region (3'UTR) of PD-1, has been associated with susceptibility and disease progression of chronic HBV infection in Far-Eastern patients. The aim of our study was to assess the impact of rs10204525 variation on HBV infection in Moroccan patients...
July 17, 2018: Journal of Medical Virology
Kei Morio, Michio Imamura, Yoshiiku Kawakami, Yuki Nakamura, Masahiro Hatooka, Reona Morio, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, Hiroshi Aikata, C Nelson Hayes, Daiki Miki, Hidenori Ochi, Yoshio Katamura, Keiko Arataki, Takashi Moriya, Hiroyuki Ito, Keiji Tsuji, Hiroshi Kohno, Koji Waki, Toru Tamura, Toshio Nakamura, Kazuaki Chayama
BACKGROUND: Sustained virological response (SVR) rates for treatment of chronic hepatitis C virus (HCV) infected patients have drastically improved with the use of direct-acting antiviral (DAA) therapies; however, a small minority of patients still fails to eradicate the virus. We analyzed factors associated with SVR in DAA therapy and the effect of age and liver fibrosis on treatment response. METHODS: 918 patients with chronic HCV infection were treated with 24 weeks of daclatasvir plus asunaprevir (DCV/ASV) or 12 weeks of sofosbuvir plus ledipasvir (SOF/LDV), ombitasvir, paritaprevir plus ritonavir (OMB/PTV/r) or sofosbuvir plus RBV (SOF/RBV)...
July 17, 2018: Journal of Medical Virology
T Theis, K A Lau, J L Gray, C J Oxenford, G J Walker, W D Rawlinson
The first reported case of Middle East respiratory syndrome-coronavirus (MERS-CoV) infection was identified in Saudi Arabia in September 2012, since which time there have been over 2,000 laboratory-confirmed cases, including 750 deaths in 27 countries. Nucleic acid testing (NAT) is the preferred method for the detection of MERS-CoV. A single round of a Proficiency Testing Program (PTP) was used to assess the capability of laboratories globally to accurately detect the presence of MERS-CoV using NAT. A panel of eleven lyophilized specimens containing different viral loads of MERS-CoV, common coronaviruses, and in vitro RNA transcripts was distributed to laboratories in all six WHO Regions...
July 17, 2018: Journal of Medical Virology
Thanh Cong Bui, Michael E Scheurer, Vy Thi-Tuong Pham, Ly Thi-Hai Tran, Leng Bun Hor, Damon J Vidrine, Michael W Ross, Christine M Markham
OBJECTIVES: Intravaginal practices (IVPs) include washing, wiping, or inserting something inside the vagina. This study investigates the associations between IVPs and genital human papillomavirus (HPV) infection. METHODS: We conducted a cross-sectional study of 200 female sex workers aged 18-35 years in Phnom Penh, Cambodia from August-September 2014. Data on sociodemographic characteristics, IVPs, and other behaviors were collected through face-to-face interviews...
July 17, 2018: Journal of Medical Virology
Can Liu, Wennan Wu, Shongyan Shang, Er Huang, Zhen Xun, Jinpiao Lin, Tianbin Chen, Bin Yang, Jing Chen, Qishui Ou
The detection of HBV DNA plays a critical role in determining the level of viral replication in HBV infected patients. However, how to select appropriate HBV DNA detection method, low-sensitivity (ls) and hypersensitivity (hs), remains unclear. In this study, HBsAg, HBeAg, ALT, AST and hs HBV DNA titers in serum of 5611 cases with suspected HBV infection were reviewed. Besides, the dynamic changes of HBV DNA and HBsAg in 85 chronic hepatitis B (CHB) patients receiving PegIFNα or entecavir (ETV) were observed...
July 16, 2018: Journal of Medical Virology
John Tembo, Kanta Chandwe, Mwila Kabwe, Moses Chilufya, Ornella Ciccone, Evans Mpabalwani, Dharam Ablashi, Alimuddin Zumla, Tie Chen, Matthew Bates
BACKGROUND: Human herpesvirus 6B (HHV-6B) is the causative agent of Roseola infantum, and has also been suggested to play a role in the pathogenesis of febrile seizures in young children, a percentage of whom go on to develop febrile status epilepticus (FSE), but existing data is conflicting and inconclusive. HHV-6A is a distinct species, rarely detected in most parts of the world, but prior studies suggest a higher prevalence in febrile African children. We describe a case control study comparing the frequency of HHV-6A and/or HHV-6B infections in children with febrile seizures (including febrile status epilepticus) and a control group of febrile children without seizures...
July 16, 2018: Journal of Medical Virology
Mohamed Hashem, Hassan Zaghla, Zainab Zakaria, Walaa R Allam, Eman Abdel Sameea, Nabiel N Mikhail, Maha Sobhy, Iman F Galal, Yasser Mokhtar, Shimaa Hamdy, Gehan Galal, Sayed F Abdelwahab, Imam Waked
Acute Hepatitis C (AHC) infections, resolves spontaneously in 15-40% of patients. Factors favoring spontaneous viral clearance remain undefined. In this study, predictors of spontaneous viral clearance in symptomatic AHC patients were investigated. Epidemiological, clinical and virologic parameters were also examined. Symptomatic AHC patients were enrolled and followed prospectively. Patients were followed every 2 weeks in the first month then monthly for the following five months, with a follow-up visit six months after the last HCV-RNA negative sample for those who cleared the virus...
July 16, 2018: Journal of Medical Virology
Suguru Takeuchi, Jun-Ichi Kawada, Yusuke Okuno, Kazuhiro Horiba, Takako Suzuki, Yuka Torii, Kazushi Yasuda, Atsushi Numaguchi, Taichi Kato, Yoshiyuki Takahashi, Yoshinori Ito
Myocarditis is an inflammatory disease of the myocardium, leading to cardiac dysfunction and heart failure. Although viral infections are considered to be the most common etiology of myocarditis, identification of the causative virus is still challenging. Recently, next-generation sequencing (NGS) has been applied in the diagnosis of infectious diseases. The aim of the present study was to comprehensively analyze potential pathogenic microorganisms using NGS in sera of patients with myocarditis. Twelve pediatric and five adult patients hospitalized for acute myocarditis were included...
July 16, 2018: Journal of Medical Virology
Atthapon Jaishuen, Nida Jareemit, Somsak Laiwejpithaya, Boonlert Viriyapak, Mongkol Benjapibal, Navin Horthongkham
PURPOSE: To evaluate the performance of Siriraj liquid-based solution for HPV DNA testing compared with standard transport media METHODS: This cross-sectional study enrolled 217 women aged 30 years or older who attended for cervical cancer screening or had abnormal cervical cytology or were diagnosed with cervical cancer at the Department of Obstetrics-Gynecology, Siriraj Hospital from March 2015 to January 2016. We excluded patients with a history of any cervical procedures, hysterectomy, or previous treatment with pelvic irradiation or chemotherapy...
July 11, 2018: Journal of Medical Virology
Kanittapon Supadej, Pattara Khamrin, Kattareeya Kumthip, Rungnapa Malasao, Natthawan Chaimongkol, Mayuko Saito, Hitoshi Oshitani, Hiroshi Ushijima, Niwat Maneekarn
Norovirus (NoV) and sapovirus (SaV) are recognized as the causative agents of acute gastroenteritis, and NoV is one of the leading pathogens reported worldwide. This study reports on the distribution of NoV and SaV genotypes in children hospitalized with acute gastroenteritis in Chiang Mai, Thailand from January 2015 to February 2017. From a total of 843 stool samples, 170 (20.2%) and 16 (1.9%) were identified as showing NoV and SaV infections, respectively. Two samples (0.2%) were positive for both NoV and SaV...
July 11, 2018: Journal of Medical Virology
Kazumi Yamasaki, Junko Tanaka, Akemi Kurisu, Tomoyuki Akita, Masayuki Ohisa, Kazuaki Sakamune, Ko Ko, Aya Sugiyama, Takahiro Yasaka, Satoshi Shirahama
This population-based study examined the natural course of hepatitis B e antigen (HBeAg)-positive or -negative persistent hepatitis B virus (HBV) infection, adjusted by age and liver disease states using a Markov model. Using 12,417 person-years data (n=862), annual transition probabilities were estimated, and age-adjusted cumulative incidence and natural history of persistent HBV infection were simulated in both sexes of Groups 1 (HBeAg-negative status with HBV DNA level <4.0 logIU/mL at entry) and 2 (persistent HBeAg-positive status throughout the study)...
July 11, 2018: Journal of Medical Virology
Ning Zhao, Wei Zheng, Dan Wu, Xuelian Wang, Wei Yang, Lin Yuan, Zhiqiang Niu, Xiaodi Jiang, Fen Huang, Zhiwei Li
BACKGROUND & AIMS: To observe the clinical value of HCcAg levels in monitoring acute hepatitis C virus (HCV) infection in patients with spontaneous clearance or clearance induced by antiviral therapy. METHODS: Patients with iatrogenic HCV infection (n=104) were enrolled at the Shengjing Hospital, China Medical University, between February 5th, 2013 and April 3rd, 2013. All cases were diagnosed with acute HCV infection, enrolled within 90 days of infection, and followed for 12-16 weeks...
July 11, 2018: Journal of Medical Virology
Ene-Ly Jõgeda, Radko Avi, Merit Pauskar, Eveli Kallas, Tõnis Karki, Don Des Jarlais, Anneli Uusküla, Karolin Toompere, Irja Lutsar, Kristi Huik
We investigated the presence of a single nucleotide polymorphism designated rs12979860 in the interferon-lambda-4 (IFNλ4) gene among 345 people who inject drugs (PWID) and 495 blood donors to evaluate associations between the rs12979860 genotypes and HIV/HCV. The rs12979860 TT genotype was overrepresented among HIV+ PWID than HIV- PWID and blood donors (16% vs. 8% and 10%, p=0.03, respectively). PWID with TT genotype had approximately twice the probability of being HIV+ (OR=2.19, 95% CI=1.11-4.33) than PWID without TT...
July 10, 2018: Journal of Medical Virology
Giuliana Galassi, Maurilio Genovese, Marisa Meacci, Marcella Malagoli
No abstract text is available yet for this article.
July 10, 2018: Journal of Medical Virology
Herve A Kadjo, Diane Waku-Kouomou, Marius Adagba, Emily S Abernathy, Ouattara Abdoulaye, D Edgard Adjogoua, Fanta Coulibaly-Traore, Sylla Aboubacar, Ekra Daniel, Joseph Icenogle, Mireille Dosso
BACKGROUND: Rubella is a contagious disease cause by the rubella virus (RuV) that can lead to serious birth defects when women are infected in early pregnancy. This work aimed to describe the epidemiology and genetic diversity of rubella viruses in Cote d'Ivoire (CIV). MATERIAL AND METHODS: Blood or oral fluid samples collected from suspected measles cases were first tested for the presence of measles specific IgM antibodies by ELISA. All measles IgM negative or indeterminate samples were tested for rubella IgM antibody using ELISA...
July 8, 2018: Journal of Medical Virology
Bei Li, Hui Wang, Dan Yang, Jian Ma
The epidemiologic characteristics of HPV genotypes vary by age, ethnicity, geographic location and the available data of HPV epidemiological characteristics with cytology results in Sichuan province are limited. Our research was conducted from June 2016 to July 2017. A total of 10953 women getting HPV testing were enrolled. Liquid-based cytological results and histological results were collected. The overall HPV infection rate was 24.1% in Sichuan province. The prevalence of hrHPV were 19.9%. For hrHPV genotypes, HPV52 (15...
July 7, 2018: Journal of Medical Virology
Hideaki Yoshitomi, Yuki Ashizuka, Sachiko Ichihara, Tomofumi Nakamura, Asako Nakamura, Takayuki Kobayashi, Junboku Kajiwara
Coxsackievirus (CV) A6 has been the primary causative agent of hand, foot, and mouth disease (HFMD) in Japan since 2011. In Fukuoka, CV-A6-associated HFMD caused epidemics in 2013, 2015, and 2017. This paper reports the genetic characteristics of the CV-A6 entire Viral Protein 1 (VP1) derived from HFMD patients in Fukuoka between 2013 and 2017. CV-A6 was detected in 105 of 280 clinical specimens, and the entire VP1 sequences could be analyzed for 90 of the 105 specimens. Phylogenetic analysis revealed that the CV-A6 strains were classified into clade A and subgrouped into subclade A3 or subclade A4...
July 7, 2018: Journal of Medical Virology
Je Eun Song, Mi Young Ahn, Woo Joo Kim, Shin-Woo Kim, Jin Soo Lee, Nam Su Ku, Joon Hyung Kim, Ki-Hyon Kim, Heawon Ann, Jun Yong Choi
PROBLEM: The discovery of two main co-receptors for HIV, CCR5, and CXCR4 has led to a better understanding of the interaction between HIV envelope and host cells, and development of new therapeutic approaches. The purpose of this work was to estimate the prevalence of CCR5 tropism among HIV-1-infected Koreans and identify the predictors for CCR5 tropism. METHOD OF STUDY: We enrolled 250 HIV-1-infected subjects from four medical centers of three different cities in South Korea between April 2013 and May 2014...
July 7, 2018: Journal of Medical Virology
Hassan El Batae, Ibrahim Amer, Abdelrahman Kobtan, Shimaa M Saied, A A Ghazy, Ferial Elkalla, Shimaa El Sharawy
BACKGROUND: HCV constitutes a global public health problem in Egypt, as it has the highest worldwide prevalence. This study aimed at determining the seroprevalence of HCV among the newcomer students of Kafrelsheikh University, Egypt. METHODS: A cross-sectional serosurvey was conducted including 9049 students. Medical examination, ultrasonography and laboratory investigations were done. Liver functions' tests and HCV antibody testing were carried out for all students who gave an informed consent; HCV-RNA PCR was performed for students with positive HCV antibody testing...
July 7, 2018: Journal of Medical Virology
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