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Journal of Analytical Toxicology

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https://www.readbyqxmd.com/read/28204488/correction-to-simultaneous-screening-and-quantification-of-basic-neutral-and-acidic-drugs-in-blood-using-uplc-qtof-ms
#1
Sergei Bidny, Kim Gago, Phuong Chung, Desdemona Albertyn, Daniel Pasin
No abstract text is available yet for this article.
February 16, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28201761/evaluation-of-an-automated-reader-and-color-interpretation-based-immunoassays-for-multiplexed-drug-of-abuse-testing-in-urine
#2
Seon Young Kim, Hyunjin Kim, Yeongchun Park, Jinsook Lim, Jimyung Kim, Sun Hoe Koo, Gye Cheol Kwon
No abstract text is available yet for this article.
February 13, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28184434/tell-tale-snps-the-role-of-cyp2b6-in-methadone-fatalities
#3
Taha Ahmad, Samie Sabet, Donald A Primerano, Lauren L Richards-Waugh, Gary O Rankin
No abstract text is available yet for this article.
February 10, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28168281/medical-findings-and-toxicological-analysis-in-infant-death-by-balloon-gas-asphyxia-a-case-report
#4
Eva Cuypers, Elien Rosier, Sara Loix, Wim Develter, Wouter Van Den Bogaert, Joke Wuestenbergs, Wim Van de Voorde, Jan Tytgat
No abstract text is available yet for this article.
February 7, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28164228/electrothermal-vaporization-qqq-icp-ms-for-determination-of-chromium-in-mainstream-cigarette-smoke-particulate
#5
Mark R Fresquez, Nathalie Gonzalez-Jimenez, Naudia Gray, Liza Valentin-Blasini, Clifford H Watson, R Steven Pappas
No abstract text is available yet for this article.
February 6, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28158759/a-cluster-of-fentanyl-laced-heroin-deaths-in-2015-in-melbourne-australia
#6
Luke N Rodda, Jennifer L Pilgrim, Matthew Di Rago, Kerryn Crump, Dimitri Gerostamoulos, Olaf H Drummer
No abstract text is available yet for this article.
February 3, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28158482/pharmacokinetic-profile-of-oral-cannabis-in-humans-blood-and-oral-fluid-disposition-and-relation-to-pharmacodynamic-outcomes
#7
Ryan Vandrey, Evan S Herrmann, John M Mitchell, George E Bigelow, Ronald Flegel, Charles LoDico, Edward J Cone
No abstract text is available yet for this article.
February 3, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28158698/two-cases-of-non-fatal-intoxication-with-a-novel-street-hallucinogen-3-methoxy-phencyclidine
#8
Monika Zidkova, Tomas Hlozek, Martin Balik, Ondrej Kopecky, Pavel Tesinsky, Jan Svanda, Marie Anna Balikova
No abstract text is available yet for this article.
February 2, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28158619/procedure-for-the-selection-and-validation-of-a-calibration-model-ii-theoretical-basis
#9
Brigitte Desharnais, Félix Camirand-Lemyre, Pascal Mireault, Cameron D Skinner
No abstract text is available yet for this article.
February 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28137731/clinical-presentation-autopsy-results-and-toxicology-findings-in-an-acute-n-ethylpentylone-fatality
#10
Phoutthasone Thirakul, Laura S Hair, Kirstin L Bergen, Julia M Pearson
The clinical presentation, autopsy findings and toxicology results in an acute fatality involving N-ethylpentylone, a new cathinone derivative, are described. Law enforcement transported a male who was agitated and exhibiting unusual behavior to a local hospital. Upon arrival at the hospital, his body temperature was 105.5 degrees Fahrenheit and his blood pH was 6.7. Clinical laboratory analysis revealed elevated troponins, rhabdomyolysis, hypoglycemia, hepatic and renal injury, respiratory failure and disseminated intravascular coagulation...
January 30, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28137730/procedure-for-the-selection-and-validation-of-a-calibration-model-i-description-and-application
#11
Brigitte Desharnais, Félix Camirand-Lemyre, Pascal Mireault, Cameron D Skinner
Calibration model selection is required for all quantitative methods in toxicology and more broadly in bioanalysis. This typically involves selecting the equation order (quadratic or linear) and weighting factor correctly modelizing the data. A mis-selection of the calibration model will generate lower quality control (QC) accuracy, with an error up to 154%. Unfortunately, simple tools to perform this selection and tests to validate the resulting model are lacking. We present a stepwise, analyst-independent scheme for selection and validation of calibration models...
January 30, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28119437/metabolic-patterns-of-fentanyl-meperidine-methylphenidate-tapentadol-and-tramadol-observed-in-urine-serum-or-plasma
#12
Fang Wu, Matthew H Slawson, Kamisha L Johnson-Davis
Drug testing is a useful tool to identify drug use or monitor adherence to prescription drugs. The interpretation of drug results can be complicated based on the pattern and proportional concentrations of drugs and/or drug metabolite(s). The purpose of this retrospective study was to detect the positivity rates and metabolic patterns of five prescription drugs, including fentanyl, meperidine, methylphenidate, tapentadol and tramadol. Retrospective data were retrieved from the laboratory information system in a national reference laboratory...
January 23, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28119436/validation-of-the-neogen%C3%A2-fentanyl-elisa-kit-for-blood-and-urine
#13
Nicholas B Tiscione, Kristin Wegner
The Neogen(®) Fentanyl ready-to-use enzyme-linked immunosorbent assay kit was validated following the Scientific Working Group for Forensic Toxicology Standard Practices for Method Validation in Forensic Toxicology Laboratory Guidelines. Two decision points, 0.5 and 1 ng/mL, were successfully validated for whole blood. For urine, two decision points, 1 and 5 ng/mL, were also successfully validated. The validation included the evaluation of sensitivity, precision, specificity, carryover, plate drift, ruggedness/robustness and a case sample evaluation...
January 23, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28111371/volatile-hydrocarbon-analysis-in-blood-by-headspace-solid-phase-microextraction-the-interpretation-of-vhc-patterns-in-fire-related-incidents
#14
Brian Waters, Kenji Hara, Natsuki Ikematsu, Mio Takayama, Masayuki Kashiwagi, Aya Matsusue, Shin-Ichi Kubo
A headspace solid-phase microextraction (HS-SPME) technique was used to quantitate the concentration of volatile hydrocarbons from the blood of cadavers by cryogenic gas chromatography-mass spectroscopy. A total of 24 compounds including aromatic and aliphatic volatile hydrocarbons were analyzed by this method. The analytes in the headspace of 0.1 g of blood mixed with 1.0 mL of distilled water plus 1 µL of an internal standard solution were adsorbed onto a 100-µm polydimethylsiloxane fiber at 0°C for 15 min, and measured using a GC-MS full scan method...
January 22, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28111370/modified-method-for-detection-of-benzoylecgonine-in-human-urine-by-gc-ms-derivatization-using-pentafluoropropanol-acetic-anhydride
#15
Michelle C Serafin, Kasandra M Paulemon, Zachary J Fuller, William E Bronner
An existing GC-MS method for detecting benzoylecgonine (BZE) in urine was modified by changing derivatizing reagents. This method modification presents a cost-effective alternative derivatization procedure for the detection of BZE in urine by GC-MS. The combination of pentafluoropropanol and acetic anhydride was found to produce the same reaction product for BZE as pentafluoropropanol with pentafluoropropionic anhydride, while reducing reagent cost. With no anhydride present, derivatization of BZE by pentafluoropropanol did not occur...
January 22, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28096302/postmortem-and-toxicological-findings-in-a-series-of-furanylfentanyl-related-deaths
#16
Davide Guerrieri, Emma Rapp, Markus Roman, Henrik Druid, Robert Kronstrand
Over the course of 4 months in 2015 and 2016, a cluster of seven fatal intoxications involving the opioid-analogue furanylfentanyl occurred in Sweden; toxicological analysis showed presence of furanylfentanyl either as the only drug or in combination with other illicit substances. Previous publications have only reported non-lethal furanylfentanyl intoxications. In the cases presented here, furanylfentanyl intoxication-alone or in combination with other drugs-was determined to be the cause of death by the responsible pathologist...
January 17, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28069869/determination-of-%C3%A2-9-tetrahydrocannabinol-thc-11-hydroxy-thc-11-nor-9-carboxy-thc-and-cannabidiol-in-human-plasma-using-gas-chromatography-tandem-mass-spectrometry
#17
David M Andrenyak, David E Moody, Matthew H Slawson, Daniel S O'Leary, Margaret Haney
Two marijuana compounds of particular medical interest are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). A gas chromatography-tandem mass spectrometry (GC-MS-MS) method was developed to test for CBD, THC, hydroxy-THC (OH-THC) and carboxy-THC (COOH-THC) in human plasma. Calibrators (THC and OH-THC, 0.1 to 100; CBD, 0.25 to 100; COOH-THC, 0.5-500 ng/mL) and controls (0.3, 5 and 80 ng/mL, except COOH-THC at 1.5, 25 and 400 ng/mL) were prepared in blank matrix. Deuterated (d3) internal standards were added to 1-mL samples...
January 8, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28069868/liquid-chromatography-tandem-mass-spectrometric-analysis-of-octaethylene-glycol-monodecyl-ether-in-rat-plasma-and-its-application-to-pharmacokinetic-studies
#18
Hyeon Kim, Hyeong Jun Kim, Min Sun Choi, In Sook Kim, Myung Chan Gye, Hye Hyun Yoo
Alcohol ethoxylates (AEs) are a major class of non-ionic surfactants, which are widely used in household, institutional and industrial cleaners, and they are considered as an alternative of nonylphenol. In this study, a rapid, sensitive and reliable bioanalytical method was developed for the determination of octaethylene glycol monodecyl ether (C10E8, an AE) in rat plasma using liquid chromatography-tandem mass spectrometry (LC-MS-MS). Chromatographic separation was performed on a reversed-phase C18 column (2...
January 8, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28035035/analysis-of-u-47700-a-novel-synthetic-opioid-in-human-urine-by-lc-ms-ms-and-lc-qtof
#19
Steven W Fleming, Justin C Cooley, Leonard Johnson, C Clinton Frazee, Kristina Domanski, Kurt Kleinschmidt, Uttam Garg
The illicit drug market has rapidly evolved from synthetic cannabinoids to cathinone derivatives and now a new emerging threat of synthetic opioids. These compounds were mostly developed by pharmaceutical companies during drug discovery. The new psychoactive substances are not routinely covered in drug screening and may go undetected. Recently fentanyl analogous, AH-7921, MT-45 and now U-47700 have been encountered in clinical and forensic casework. U-47700 is gaining popularity on drug user forms as a legal alternative to heroin...
December 29, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28035034/identification-of-suvorexant-in-urine-using-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-lc-q-tof-ms
#20
Sydney Sullinger, Kelsie Bryand, Sarah Kerrigan
Suvorexant (Belsomra(®)) is a new hypnotic drug with a novel mechanism of action. In prescribed doses of 10 mg before bedtime, the drug produces rapid onset of sleep by inhibiting the orexin neurons of the arousal system, promoting decreased wakefulness. Suvorexant is a potent and highly selective dual orexin receptor antagonist. Sedative hypnotics are of forensic importance due to their widespread use, potential for additive effects with other central nervous system depressants, impairing effects and potential for misuse...
December 29, 2016: Journal of Analytical Toxicology
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