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Journal of Analytical Toxicology

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https://www.readbyqxmd.com/read/28334921/internal-hydrolysis-indicator-for-sample-specific-monitoring-of-%C3%AE-glucuronidase-activity
#1
Lacy L Taylor, Noah A Flint, Vinh Ma, Brandy M Hill, Chantry J Clark, Frederick G Strathmann
Metabolized forms of benzodiazepines (benzos) can cause issues with mass spectrometry identification. Benzodiazepines undergo a process called glucuronidation during metabolism that attaches a glucuronic acid for increased solubility. Often in clinical testing an enzymatic hydrolysis step is implemented to increase the sensitivity of benzodiazepines by hydrolyzing β-D-glucuronic acid from benzodiazepine-glucuronide conjugates in urine samples using the β-Glucuronidase enzyme. In this study resorufin β-D-glucuronide, a substrate of the β-Glucuronidase enzyme, was added to patient samples to determine if proper hydrolysis had occurred...
March 18, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28334957/quechers-based-method-for-pesticides-analysis-in-adipose-tissue-associated-with-rat-ovaries
#2
Nathalie Zamariola, Pedro Toledo Netto, Carla Adriene da Silva Franchi, João Lauro Viana de Camargo, Mary Rosa Rodrigues de Marchi
The concomitant exposure to low doses of various pesticides is one of the most relevant issues in human toxicology today. An experimental toxicology study was developed to evaluate the effects of this type of exposure on the reproductive capacity of females of three species of rats that were exposed to mixtures of dicofol, dieldrin, endosulfan and permethrin at low doses (LOAEL and NOAEL). In this context, we have developed a method for determining pesticides in adipose tissue (0.5 g, 49% lipid) associated with the ovaries, based on the QuEChERS (quick, easy, cheap, effective, rugged and safe) strategy...
March 14, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28335036/validated-method-for-the-screening-and-quantification-of-baclofen-gabapentin-and-pregabalin-in-human-post-mortem-whole-blood-using-protein-precipitation-and-liquid-chromatography-tandem-mass-spectrometry
#3
Limon Nahar, Amy Smith, Rajan Patel, Rebecca Andrews, Sue Paterson
There has been a rapid increase in the number of prescriptions for baclofen (BLF), gabapentin (GBP) and pregabalin (PGL) in the UK since their introduction to therapy. Recent studies across the European Union and USA have shown the illicit abuse potential of these drugs and deaths have been observed. A simple, reliable and fully validated method was developed for the screening and quantification of BLF, GBP and PGL in human post-mortem (PM) blood. The analytes and their deuterated analogs as internal standard were extracted from blood using a single addition acetonitrile protein precipitation reaction followed by analysis using liquid chromatography-tandem mass spectrometry (LC-MS-MS) with triggered dynamic multiple reaction monitoring mode for simultaneous confirmation and quantification...
March 10, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28334901/benzonatate-toxicity-nothing-to-cough-at
#4
Sandra C Bishop-Freeman, Erin M Shonsey, Laura W Friederich, Michael C Beuhler, Ruth E Winecker
No abstract text is available yet for this article.
March 10, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28334805/hair-testing-for-drugs-of-abuse-and-new-psychoactive-substances-in-a-high-risk-population
#5
Alberto Salomone, Joseph J Palamar, Enrico Gerace, Daniele Di Corcia, Marco Vincenti
Hundreds of new psychoactive substances (NPS) have emerged in the drug market over the last decade. Few drug surveys in the USA, however, ask about use of NPS, so prevalence and correlates of use are largely unknown. A large portion of NPS use is unintentional or unknown as NPS are common adulterants in drugs like ecstasy/Molly, and most NPS are rapidly eliminated from the body, limiting efficacy of urine, blood and saliva testing. We utilized a novel method of examining prevalence of NPS use in a high-risk population utilizing hair-testing...
March 4, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28335030/urinary-kinetics-of-heroin-metabolites-in-pigs-shortly-after-intake
#6
Gudrun Høiseth, André Gottås, Thomas Berg, Marianne Arnestad, Per Steinar Halvorsen, Liliana C Bachs
In previous experimental studies on heroin metabolites excretion in urine, the first sample was often collected a few hours after intake. In forensic cases, it is sometimes questioned if a positive urine result is expected e.g., 30 min after intake. The aim of this study was to investigate urinary excretion of heroin metabolites (morphine, 6-monoacetylmorphine (6-MAM) and morphine-3-glucuronide (M3G)) every 30 min until 330 min after injection of a 20 mg heroin dose in six pigs. Samples were analyzed using a previously published, fully validated liquid chromatography-tandem mass spectrometry method...
February 27, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28334841/oral-fluid-testing-for-cocaine-analytical-evaluation-of-two-point-of-collection-drug-screening-devices
#7
Juliana Nichterwitz Scherer, Taís Regina Fiorentin, Tanara Rosangela Vieira Sousa, Renata Pereira Limberger, Flavio Pechansky
The use of point-of-collection testing (POCT) devices for drugs of abuse in oral fluid (OF) is an advantageous tool that has been used for different purposes-particularly traffic enforcement. However, even with the widespread report of cocaine consumption, the reliability of POCT devices has been reported in different magnitudes. This study evaluated the reliability of two POCT devices for the detection of cocaine in OF samples of 110 cocaine users: (i) the DDS2™ (cutoff = 30 ng/mL) and (ii) the Multi-Drugs Multi-Line-Twist Screen Test Device™ (MDML) (cutoff = 20 ng/mL)...
February 27, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28334840/review-of-caffeine-related-fatalities-along-with-postmortem-blood-concentrations-in-51-poisoning-deaths
#8
Alan Wayne Jones
Publications reporting concentrations of caffeine in postmortem blood were reviewed if the cause of death was attributed to overdosing (poisoning) with drugs. Age and gender of the deceased, the manner of death (accident, suicide or undetermined) and types of co-ingested drugs were evaluated in relation to the concentrations of caffeine in blood (N = 51). The mean age (±SD) of the victims was 39 ± 17.8 years (range 18-84 years) and most were female (N = 31 or 61%). The difference in mean age of males (42 ± 17...
February 18, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28334817/stability-of-synthetic-cannabinoids-in-biological-specimens-analysis-through-liquid-chromatography-tandem-mass-spectrometry
#9
Chelsea Fort, Thomas Jourdan, Jesse Kemp, Byron Curtis
The focus of this study was to determine the stability of four synthetic cannabinoids, XLR-11, UR-144, AB-Pinaca and AB-Fubinaca in biological specimens for the purpose of casework processing prioritization. The study used human whole blood spiked with the compounds of interest to mimic real forensic laboratory samples submitted for synthetic cannabinoid analysis. The spiked whole blood specimens were incubated under one of three temperature conditions: room or ambient (22°C), refrigerated (4°C) and frozen (-20°C) for a period of 12 weeks...
February 18, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28204488/correction-to-simultaneous-screening-and-quantification-of-basic-neutral-and-acidic-drugs-in-blood-using-uplc-qtof-ms
#10
Sergei Bidny, Kim Gago, Phuong Chung, Desdemona Albertyn, Daniel Pasin
No abstract text is available yet for this article.
February 16, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28201761/evaluation-of-an-automated-reader-and-color-interpretation-based-immunoassays-for-multiplexed-drug-of-abuse-testing-in-urine
#11
Seon Young Kim, Hyunjin Kim, Yeongchun Park, Jinsook Lim, Jimyung Kim, Sun Hoe Koo, Gye Cheol Kwon
No abstract text is available yet for this article.
February 13, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28184434/tell-tale-snps-the-role-of-cyp2b6-in-methadone-fatalities
#12
Taha Ahmad, Samie Sabet, Donald A Primerano, Lauren L Richards-Waugh, Gary O Rankin
No abstract text is available yet for this article.
February 10, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28168281/medical-findings-and-toxicological-analysis-in-infant-death-by-balloon-gas-asphyxia-a-case-report
#13
Eva Cuypers, Elien Rosier, Sara Loix, Wim Develter, Wouter Van Den Bogaert, Joke Wuestenbergs, Wim Van de Voorde, Jan Tytgat
No abstract text is available yet for this article.
February 7, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28164228/electrothermal-vaporization-qqq-icp-ms-for-determination-of-chromium-in-mainstream-cigarette-smoke-particulate
#14
Mark R Fresquez, Nathalie Gonzalez-Jimenez, Naudia Gray, Liza Valentin-Blasini, Clifford H Watson, R Steven Pappas
No abstract text is available yet for this article.
February 6, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28158759/a-cluster-of-fentanyl-laced-heroin-deaths-in-2015-in-melbourne-australia
#15
Luke N Rodda, Jennifer L Pilgrim, Matthew Di Rago, Kerryn Crump, Dimitri Gerostamoulos, Olaf H Drummer
No abstract text is available yet for this article.
February 3, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28158482/pharmacokinetic-profile-of-oral-cannabis-in-humans-blood-and-oral-fluid-disposition-and-relation-to-pharmacodynamic-outcomes
#16
Ryan Vandrey, Evan S Herrmann, John M Mitchell, George E Bigelow, Ronald Flegel, Charles LoDico, Edward J Cone
No abstract text is available yet for this article.
February 3, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28158698/two-cases-of-non-fatal-intoxication-with-a-novel-street-hallucinogen-3-methoxy-phencyclidine
#17
Monika Zidkova, Tomas Hlozek, Martin Balik, Ondrej Kopecky, Pavel Tesinsky, Jan Svanda, Marie Anna Balikova
No abstract text is available yet for this article.
February 2, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28158619/procedure-for-the-selection-and-validation-of-a-calibration-model-ii-theoretical-basis
#18
Brigitte Desharnais, Félix Camirand-Lemyre, Pascal Mireault, Cameron D Skinner
No abstract text is available yet for this article.
February 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28137731/clinical-presentation-autopsy-results-and-toxicology-findings-in-an-acute-n-ethylpentylone-fatality
#19
Phoutthasone Thirakul, Laura S Hair, Kirstin L Bergen, Julia M Pearson
The clinical presentation, autopsy findings and toxicology results in an acute fatality involving N-ethylpentylone, a new cathinone derivative, are described. Law enforcement transported a male who was agitated and exhibiting unusual behavior to a local hospital. Upon arrival at the hospital, his body temperature was 105.5 degrees Fahrenheit and his blood pH was 6.7. Clinical laboratory analysis revealed elevated troponins, rhabdomyolysis, hypoglycemia, hepatic and renal injury, respiratory failure and disseminated intravascular coagulation...
January 30, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28137730/procedure-for-the-selection-and-validation-of-a-calibration-model-i-description-and-application
#20
Brigitte Desharnais, Félix Camirand-Lemyre, Pascal Mireault, Cameron D Skinner
Calibration model selection is required for all quantitative methods in toxicology and more broadly in bioanalysis. This typically involves selecting the equation order (quadratic or linear) and weighting factor correctly modelizing the data. A mis-selection of the calibration model will generate lower quality control (QC) accuracy, with an error up to 154%. Unfortunately, simple tools to perform this selection and tests to validate the resulting model are lacking. We present a stepwise, analyst-independent scheme for selection and validation of calibration models...
January 30, 2017: Journal of Analytical Toxicology
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