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Tokai Journal of Experimental and Clinical Medicine

Yuki Saito, Yasuhiro Suzuki, Chie Inomoto, Nobue Kumaki, Kozue Yokoyama, Rin Ogiya, Risa Oshitanai, Mayako Terao, Banri Tsuda, Tooru Morioka, Naoki Niikura, Takuho Okamura, Shinobu Masuda, Yutaka Tokuda
We report a patient with a giant phyllodes tumor of the right breast associated with a hypoglycemic attack. A 48-year-old woman experienced a loss of consciousness and was transferred via ambulance to our hospital emergency department. Upon arrival, her blood glucose level was 26 mg/dl, and a giant tumor (>20 cm in diameter) with skin ulceration was observed on the right breast. Core needle biopsy led to a histological diagnosis of a phyllodes tumor of the breast. Ultrasonography and computed tomography detected neither distant metastasis nor a pancreatic endocrine tumor...
September 20, 2016: Tokai Journal of Experimental and Clinical Medicine
Mitsuhiko Kodama, Michi Tochikura, Naoshi Shimoda, Chieko Fujii, Toshiyuki Fujiwara, Yoshihisa Masakado
INTRODUCTION: The second lumbrical-interossei latency difference test (2LINT) is used frequently for electrodiagnosis of carpal tunnel syndrome (CTS). A premotor potential observed with 2LINT has been identified as a median-nerve sensory nerve action potential. We evaluated the utility of the premotor potential latency analysis (i.e., premotor potential study; PPS) for CTS electrodiagnosis. METHODS: Sensitivity, specificity, and percentage "no evoked response" (%NER) values were compared prospectively among PPS, median-nerve sensory nerve-conduction studies (NCSs) for digits 1, 2, and 4, and palmar mixed NCS...
June 20, 2016: Tokai Journal of Experimental and Clinical Medicine
Nandin E Enkhbaatar, Shun Ono, Tamaki Ichikawa, Akio Hoshi, Toshiro Terachi, Go Ogura, Yusuke Kondo, Masae Ikeda, Yutaka Imai
A 58-year-old Japanese female was admitted to our hospital for treatment of ovarian cancer. She had no urinary tract symptoms at the time of presentation. Preoperative CT (Computed Tomography) was performed for surgical planning, and it revealed two left-sided ureters including a short ureter with a blind, cystic ending and a short ureter joined to the main ureter before entering into the bladder. On CT urography, these radiological findings were compatible with a blind-ending bifid ureter. Preoperatively, a double J stent was inserted into the normal left ureter, and then the blind-ending bifid ureter was resected before an ovarian cancer operation...
April 2016: Tokai Journal of Experimental and Clinical Medicine
Ferdnand C Osuagwu, Benedict Amalraj, Bernard D Noveloso, Salisu A Aikoye, Ronald Bradley
Very few studies have shown associations between autism spectrum disorder, attention deficit hyperactivity disorder and Chiari 1 malformation. Here, we report an 10-year-old male that presented after having seizures with a history of Chiari 1 malformation, autism spectrum disorder and ADHD with moderate mental retardation and speech delay. This case highlights the fact that autism spectrum disorder as biologically based neurodevelopmental disorder with altered brain growth may be associated with Chiari 1 malformation and ADHD...
April 2016: Tokai Journal of Experimental and Clinical Medicine
Tomomi Hatanaka, Eri Takeuchi, Akira Katoh, Tsutomu Yamaki, Masaki Uchida, Hideshi Natsume
OBJECTIVE: To develop a bioadhesive phosphorescent particle that can be used as a marker in video-oculography to assess eye movements in the dark without drug treatment. METHODS: The marker was prepared by spray-coating a Sr4Al14O25: Eu2+, Dy3+ phosphor with a carboxyvinyl polymer. The morphologic, luminescent and adhesive properties were assessed. The dynamic properties of VOR measured by the marker were compared with those obtained by tracking the pupil under miotic treatment...
April 2016: Tokai Journal of Experimental and Clinical Medicine
Chisa Narayama, Masae Ikeda, Miwa Yasaka, Yu-suke Sagara, Yasuhira Kan-no, Io Hayashi, Atuya Narita, Satoshi Asai, Toshiki Tajima, Masako Shida, Takeshi Hirasawa, Mikio Mikami
We report a case of vulvar aggressive angiomyxoma (AA) which is a rare, slow growing and benign tumor of mesenchymal origin, but has a high risk of local recurrence. A 49-year-old Japanese female was referred to us with a large mass of the left vulva, measuring 15×9.5×9 centimeters. She underwent surgical excision of the tumor with no evidence of recurrence on a 5-year follow up. In this case, histopathological examination and immunohistochemical staining after excision revealed a diagnosis of vulvar AA with estrogen and progesterone receptors positive...
April 2016: Tokai Journal of Experimental and Clinical Medicine
Natsumi Kitajima, Toshiro Seki, Atsushi Yasuda, Masayuki Oki, Atsushi Takagi, Kazuya Hanai, Toshiro Terachi, Masafumi Fukagawa
We report a rare case of subclinical primary aldosteronism (PA) and subclinical Cushing's syndrome (CS). A 49-year-old woman was referred to our hospital for the evaluation of an adrenal incidentaloma. The patient had no previous medical history and no family history of notable illness. Her blood pressure was 103/60 mmHg. She had no Cushingoid features. Routine laboratory examinations were within the normal ranges including normokalemia. Based on the endocrinological results and imaging findings, we finally made a diagnosis of subclinical PA caused by both adrenal glands and subclinical CS caused by bilateral adrenal tumors...
April 2016: Tokai Journal of Experimental and Clinical Medicine
Tomoki Nakamura, Osamu Chino, Daiki Yokoyama, Yoichi Tanaka, Tomoko Hanashi, Masahiro Kikuchi, Takafumi Ogawa, Takayuki Tajima, Sotaro Sadahiro, Yasumasa Kondoh, Hiroyasu Makuuchi
The patient was a 70-year-old man. Hepatic dysfunction was found in 1988 and chronic hepatitis C was diagnosed in 1993. He received interferon-alpha therapy, but did not respond to it. Thereafter, he was treated with ursodeoxycholic acid. In September 2010, abdominal ultrasound showed a hypoechoic tumor (29 × 25 mm) in the lower pole of the spleen, and this lesion became larger one year later (74 × 66 × 71 mm). Abdominal CT revealed a hypovascular heterogeneous tumor with smooth margins on both dynamic and delayed phase scans...
April 2016: Tokai Journal of Experimental and Clinical Medicine
Makoto Arai, Yoshinobu Nakada, Kagemasa Kajiwara, Minoru Kimura, Naoaki Ishii
OBJECTIVE: The aim of this study was to develop a method of removing sennoside to reduce the cathartic effect of rhubarb while conserving its other pharmacological activities. METHODS: Rhubarb powder was steam autoclaved at 121°C and 0.14 MPa for 20, 60, or 120 minutes, and HPLC analysis was conducted to determine levels of rhubarb components. Mice were fed non-autoclaved or 20-minute-autoclaved rhubarb extracts. Feces were collected and weighed over a 24-hour period...
April 2016: Tokai Journal of Experimental and Clinical Medicine
Jin Imai, Hitoshi Ichikawa, Hajime Mizukami, Takayoshi Suzuki, Norihito Watanabe, Tetsuya Mine
We reported a case of sigmoid colonic high grade tubular adenomas associated with deposited ova of Schistosoma japonicum. A 76-year-old Japanese man was referred to our colonoscopy due to a positive fecal occult blood test. He had a medical history of schistosomiasis japonica. The colonoscopy revealed that there were two sigmoid colon polyps, approximately 8 mm in diameter. These were removed by endoscopic mucosal resection (EMR). Pathological examination revealed high grade tubular adenomas and deposited some ova of Schistosoma japonicum with severe fibrotic change and granuloma formation in the submucosal layer...
April 2016: Tokai Journal of Experimental and Clinical Medicine
Oluwatosin A Adaramoye, Aderemi O Kehinde, Adedoyin Adefisan, Olugbenga Adeyemi, Idowu Oyinlola, Olubukola O Akanni
BACKGROUND: Tuberculosis (TB) is an infectious disease of international health priority. The combination of anti-TB drugs (4-Tabs)- isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (ETB) are effective in the management of the disease, however, their toxic effect is a major concern. PURPOSE: The study was designed to evaluate the toxicity of anti-TB drugs in male Wistar rats and possible ameliorative effects of kolaviron (KV), a biflavonoid from Garcinia kola seeds...
April 2016: Tokai Journal of Experimental and Clinical Medicine
Akihiro Ueda, Masayuki Oki, Hidetaka Yanagi, Hideki Ozawa, Atsushi Takagi
OBJECTIVE: The aim of our study was to describe the clinical characteristics of Legionella pneumonia diagnosed with a positive urinary antigen test, and factors associated with severe Legionella pneumonia were investigated. METHODS: We retrospectively investigated the clinical characteristics of patients with Legionella pneumonia diagnosed at Tokai University Hospital between February 2006 and June 2012. The clinical characteristics of ICU cases and non-ICU cases were compared...
April 2016: Tokai Journal of Experimental and Clinical Medicine
Kazuhide Takeyama, Masaaki Miura, Keiko Nakayama, Toshiyasu Suzuki
A 86-year-old female with nonvalvular atrial fibrillation (NOVAF) who did not receive prophylactic anticoagulant treatment visited our hospital because of gastrointestinal symptoms. At first, acute gastroenteritis was suspected, but later she developed ileus and she was diagnosed with superior mesenteric artery occlusion (SMAO). We successfully performed the anesthetic management of this patient and subtotal resection of the small intestine was performed. Heparin was initiated after surgery, but she developed cerebral infarction later, and finally she died due to infection and anemia caused by melena...
April 2016: Tokai Journal of Experimental and Clinical Medicine
Hiroyuki Otsuka, Toshiki Sato, Seiji Morita, Yoshihide Nakagawa, Sadaki Inokuchi
We report a 55-year-old man who relapsed into a state of shock in an ambulance before arriving at our critical care center after a fall injury. The diagnosis of cardiac tamponade was made by portable ultrasound, and immediate pericardiocentesis and drainage were performed at the heliport. He was then transported immediately to our hospital with continuous drainage and surgery was performed. After surgery, the patient was transferred to the intensive care unit in stable condition. After undergoing rehabilitation, he made a full recovery and was discharged...
April 2016: Tokai Journal of Experimental and Clinical Medicine
Masayuki Oki, Akihiro Ueda, Ayumi Tsuda, Hidetaka Yanagi, Hideki Ozawa, Atsushi Takagi
Infection with non-typhoidal Salmonella often results in a self-limited acute gastroenteritis. Extra-intestinal Salmonella infection is relatively rare and occurs predominantly in infants and adults with significant underlying conditions. We describe a 54-year-old Japanese man with a history of heavy alcohol consumption and daily contact with a dog, who developed bacteremia complicated by vertebral osteomyelitis, spinal epidural abscess, and meningitis, due to Salmonella enterica serotype Enteritidis. This case suggests that Salmonella should be considered as an etiologic pathogen in adult patients with perivertebral infection or meningitis...
2016: Tokai Journal of Experimental and Clinical Medicine
Tadashi Hashida, Koichiro Yoshioka, Shigetaka Kanda, Daisuke Fujibayashi, Mari Amino, Yuji Ikari
Pulmonary vein isolation (PVI) with radio-frequency catheter ablation (RFCA) is effective therapy for the patients with paroxysmal atrial fibrillation (pAF). However, it is not easy to predict relapse of pAF. Approximately 70% pAF patients were maintained sinus rhythm for 1 year after PVI in Japan. In this study, all of the cases were underwent chest computed tomography (CT) to check for the morphology and positional relationship of the left atrium. We detected relapse cases that exhibited spur formation in the thoracic vertebrae...
2016: Tokai Journal of Experimental and Clinical Medicine
Takashi Yasuda, Yuka Kodera, Kazuyuki Iijima, Atsushi Mizuma, Kentaro Tokuoka, Hirohisa Okuma, Shunya Takizawa, Yasuhisa Kitagawa, Shigeru Nogawa
OBJECTIVE: Cerebral white matter lesions (WMLs) have been frequently observed on MRI in patients with migraine. We investigated characteristics of WMLs in migraine and tried to determine the relationship between its causal mechanism and arteriosclerosis. METHODS: A head MRI was performed in juvenile migraine patients. The distributions of deep and periventricular WMLs were separately studied in the anterior and posterior circulation. Grading was conducted according to the Fazekas classification...
2016: Tokai Journal of Experimental and Clinical Medicine
Masakazu Nagaoka, Naoko Tsumuraya, Masaki Nie, Yuji Ikari
The occurrence of allergy to iodinated contrast in certain patients may prevent the use of percutaneous coronary intervention (PCI) in such cases. We present a 53-year-old male with a history of allergic reaction to iodinated contrast who successfully underwent intravascular ultrasound (IVUS) guided PCI. Stent size was determined based on IVUS. After PCI, stent expansion and a lack of edge dissection or incomplete apposition were confirmed by IVUS. Thus, PCI without contrast injection under IVUS may be feasible in selected patients with allergy to iodinated contrast...
2016: Tokai Journal of Experimental and Clinical Medicine
Masahiro Nitta, Akio Hoshi, Taro Higure, Yuki Shimizu, Nobuyuki Nakajima, Kazuya Hanai, Yoshiaki Kawamura, Toshiro Terachi
A 28-year-old man was hospitalized with advancing paraplegia. Under the diagnosis of Guillain-Barre syndrome, steroid pulse therapy was administered and plasmapheresis was performed. However, the paraplegia gradually progressed. Subsequently, a spinal cord tumor was revealed by magnetic resonance imaging (MRI). The pathological diagnosis, obtained by open biopsy, confirmed a mixed germ cell tumor in the spinal cord. Multiple lung and lymph nodes metastases were also detected upon computed tomography, along with increased serum alpha-fetoprotein (33...
2016: Tokai Journal of Experimental and Clinical Medicine
Yuji Koyama, Kayako Nitta, Michi Tochikura, Takashi Kasahara, Yutaka Kametsu, Minoru Toyokura, Yoshihisa Masakado
Bickerstaff's brainstem encephalitis is an autoimmune disease with the primary lesion situated in the brainstem and three cardinal signs: ophthalmoplegia; ataxia; and impaired consciousness. A 68-year-old man was started on rehabilitation exercise 3 months after onset of Bickerstaff's brainstem encephalitis, due to remnant dysarthria and dysphagia (Functional Oral Intake Scale, level 5) after the cardinal signs of Bickerstaff's brainstem encephalitis resolved. Exercise involved using a straw in the anterior midline between the dorsal tongue and hard palate...
2016: Tokai Journal of Experimental and Clinical Medicine
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