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Tokai Journal of Experimental and Clinical Medicine

Yoshimi Kondo, Mariko Nukaga, Mayumi Enseki, Hideyuki Tabata, Kota Hirai, Masahiko Kato, Hiroyuki Mochizuki
OBJECTIVE: Breath sound parameters have been suggested to be a new biomarker of airway conditions in asthmatic patients. We investigated new breath sound parameters to determine their utility for evaluating asthmatic children. METHODS: Fifty-seven children (mean age, 9.0 years, 6-16 years) were included in the present study. The new breath sound parameters, the area under the curve (AUC)>1,000 Hz (A1000 [dBm·Hz]) and the ratio of the A1000 to the total AUC at 100 Hz to the highest frequency of the dBm power spectrum (AT ) (A1000 /AT [%]) were measured before and after β2 agonist inhalation...
July 20, 2018: Tokai Journal of Experimental and Clinical Medicine
Yoshinobu Nakada, Noriyuki Takano, Makoto Arai
OBJECTIVES: Japanese traditional (Kampo) medicine has its own theories that are quite different from those of Western medicine. For many students and medical doctors, mastering it is a painstaking task. We examined the similarities in clinical reasoning between Western and Kampo medicine, and developed an easy-to-understand method to teach Kampo theories enabling physicians to make accurate diagnoses and choose suitable Kampo formulae. METHODS: We developed a teaching method for Kampo medicine along clinical reasoning for beginners and evaluate its availability and effectiveness in an actual team-based learning class...
July 20, 2018: Tokai Journal of Experimental and Clinical Medicine
Shoji Kazahari, Kazunari Honma, Reina Kawamura, Tsuyoshi Uesugi, Eiichiro Nagata, Shunya Takizawa
We present a 48-year-old man with a history of hypertension, who suddenly noticed dysarthria and right hemiparesis. Diffusion-weighted MRI at 1 day after the onset showed a small high-intensity region in the left corona radiata, indicating the acute phase of lacunar infarction. Fluid attenuation inversion recovery images showed extensive hyperintense lesions predominantly in the white matter of the fronto-temporoparietal lobes and pons, indicating posterior reversible encephalopathy syndrome (PRES). In addition, T2*-weighted gradient-echo images showed multiple small round hypointense lesions in white matter and basal ganglia, indicating cerebral microbleeds...
July 20, 2018: Tokai Journal of Experimental and Clinical Medicine
O Awodele, T D Popoola, O Idowu, B M Bashua, N A Awolola, W O Okunowo
With the introduction of Highly Active Antiretroviral Therapy (HAART), there has been drastic decline in morbidity and mortality associated with HIV/AIDS. However, many patients experience adverse drug reactions perhaps due to the inherent toxic nature of HAART. The possible toxic effect of HAART (combination ARVs) on reproduction and sexual dysfunction in seropositive HIV patients remains a subject of intense research. This study was designed to investigate the toxic effects of HAART on the reproductive hormones and organs of male and female rats...
July 20, 2018: Tokai Journal of Experimental and Clinical Medicine
Kenji Ito, Kai Yamazaki, Takugi Kan, Shuhei Tetsu, Keiichiro Saito, Mitsutomo Kohno, Masayuki Iwazaki, Toshiyasu Suzuki
We report the anesthetic management of a 65-year-old woman with recurrent, severe tracheal stenosis who underwent tracheal dilatation. She had visited the Department of Respiratory Medicine at our hospital for respiratory distress approximately 20 years ago, and had undergone laser ablation under local anesthesia. Because of recurrence and aggravation of respiratory distress, she now presented at the Department of Thoracic Surgery, and was scheduled for surgery. Percutaneous cardiopulmonary support was prepared, and she was sedated with midazolam and dexmedetomidine...
July 20, 2018: Tokai Journal of Experimental and Clinical Medicine
Takeshi Sudo, Kenji Yamamoto, Reiko Yoshikawa
Transsexuals have problems associated with self and gender identities, as well as with their relationships with specialists such as doctor and counsellors. On the basis of the principle of interpretative phenomenological analysis, an exploratory research was carried out on self by studying the psychological experiences of participants and their relationships with specialists. Consequently the following needs of the transsexuals were identified: (1) understanding and alleviation of grief, conflict, and anxiety associated with gender dysphoria; (2) recovery and improvement of self-esteem; (3) support in real-life experiences and measures related to social and legal issues, such as coming out; and (4) necessity of information provision at medical institutions and among peers...
July 20, 2018: Tokai Journal of Experimental and Clinical Medicine
Yoshihito Masuoka, Daisuke Furukawa, Naoki Yazawa, Hideki Izumi, Misuzu Yamada, Taro Mashiko, Gota Saito, Kazutake Okada, Akira Tanaka, Toshiyuki Suzuki, Sotaro Sadahiro, Kenichi Hirabayashi, Toshio Nakagohri
INTRODUCTION: Gastrointestinal neuroendocrine tumors (GI-NETs) often show hematogenous metastasis, with the liver being the most common metastatic site; however, metastasis to the pancreas is rare. CASE PRESENTATION: We report a rare case of rectal NETs with pancreatic metastases in a 75-year-old man who presented with a chief complaint of constipation. Imaging and endoscopic findings revealed a rectal submucosal tumor, a pancreatic hypovascular mass, and multiple liver masses...
July 20, 2018: Tokai Journal of Experimental and Clinical Medicine
Toshihiko Hayashi, Tamaki Ichikawa, Hiroshi Yamamuro, Shun Ono, Makiko Kobayashi, Takakiyo Nomura, Kazunobu Hashida, Hideki Yashiro, Tomohisa Okochi, Jun Koizumi, Shinichiro Shimura, Terumitsu Hasebe, Yutaka Imai
OBJECTIVE: We evaluated radiological findings and clinical significance of right aortic arch with mirror-image branching (RAMI) in adults using data from computed tomography (CT) examinations. MATERIAL AND METHODS: We reviewed recorded reports and CT images obtained from university and branch hospitals for RAMI in adults. The RAMI incidence in adults found on CT was assessed. Associated congenital and acquired cardiovascular diseases were evaluated. RESULTS: A total of 27 cases (14 men, 13 women; mean age, 59...
April 20, 2018: Tokai Journal of Experimental and Clinical Medicine
Ashok Kumar Ahirwar, Anju Jain, Archana Singh, Shilpa Bhardwaj, Binita Goswami, M K Bhatnagar, Jayashree Bhattacharjee
OBJECTIVE: To study the endothelial dysfunction by measuring Nitric Oxide and Endothelin-1, and inter-genotypic variation of inducible Nitric Oxide Synthase gene (C150T) polymorphism among the study subjects. METHODS: 50 diagnosed cases of metabolic syndrome as per International Diabetes Federation (IDF) criteria and 50 healthy volunteers as control were enrolled. Nitric Oxide, Endothelin were measured and PCR-RFLP was done to identify the iNOS gene C150T polymorphism and its effect on serum nitric oxide levels...
April 20, 2018: Tokai Journal of Experimental and Clinical Medicine
Mari Horikawa, Masao Toyoda, Nobumichi Saito, Moritsugu Kimura, Takako Kobayashi, Atsushi Takagi, Masafumi Fukagawa
Antiretroviral drugs, especially protease inhibitors (PI), are known to induce disorders of lipid and glucose metabolism. However, there are only a few reports of these side effects in patients treated with integrase strand transfer inhibitors (INSTI). We encountered the case of a 46-year-old man who had been treated for type 2 diabetes with diet and exercise. He contracted immunodeficiency virus (HIV) infection two years earlier and received highly active antiretroviral therapy (HAART). Three months before the current admission, HAART was switched from a non-nucleic acid reverse transcriptase inhibitor (NNRTI) to an INSTI (raltegravir: 800 mg/day)...
April 20, 2018: Tokai Journal of Experimental and Clinical Medicine
Yoshimi Fujii, Jun Koizumi, Takuya Hara, Tatsuya Sekiguchi, Syun Ono, Tetsuya Mine, Tatehiro Kagawa, Shunji Hirose, Kota Tsuruya, Kazuya Anzai, Bertrand Janne d'Othee, Yutaka Imai
OBJECTIVE: We describe our initial clinical experience regarding the use of a 3D roadmap during balloon-occluded retrograde transvenous obliteration (BRTO) in three patients. METHODS: Between June 2016 and July 2016, three BRTO procedures were performed in three patients with gastric varices. Preprocedural intravenous dynamic CT was performed, and portal venous phase CT images were postprocessed to obtain volume rendering (VR) images. A 3D roadmap was developed by overlaying the VR images onto the real-time X-ray fluoroscopy images...
April 20, 2018: Tokai Journal of Experimental and Clinical Medicine
Naohiro Aruga, Hiroshi Kijima, Ryota Masuda, Hiroto Onozawa, Tadashi Yoshizawa, Makiko Tanaka, Sadaki Inokuchi, Masayuki Iwazaki
Epithelial-mesenchymal transition (EMT) is an important step leading to invasion and migration of various cancer cells, and are characterized by decreased E-cadherin as an epithelial marker, and increased vimentin as a mesenchymal marker. The present study focused on the clinicopathological significance of E-cadherin and vimentin expression in lung squamous cell carcinoma (SqCC). Immunohistochemically, E-cadherin expression patterns were classified into two types: preserved or reduced; and vimentin expression patterns were also divided into two types: positive or negative...
April 20, 2018: Tokai Journal of Experimental and Clinical Medicine
Masashi Miyaoka, Go Ogura, Rurika Hamanaka, Tomoki Nakagawa, Ryota Masuda, Masayuki Iwazaki, Naoya Nakamura
Pulmonary hamartoma (PH) is usually a solid mass of less than 4 cm in size that contains cartilage omponents. A 44-year-old Japanese woman received surgical resection of a well-demarcated cystic tumor in the right lung. Resected tissue contained a 13 × 10 × 8 cm-sized solid mass with a prominent unilocular cyst (8 × 6.5 × 5 cm). The tumor was composed of a dominant smooth muscle cell (SMC) component with entrapped glandular respiratory epithelium. There was little cartilaginous or fatty tissue. Immunohistochemically, SMC was positive for smooth muscle actin (SMA) and desmin, as well as CD34...
April 20, 2018: Tokai Journal of Experimental and Clinical Medicine
Toshio Ohshima, Satomi Asai, Miki Miyazawa, Yukari Yamamoto, Akifumi Hisada, Chie Kumazawa, Masayoshi Hashimoto, Katsuji Fukawa, Hideo Iwashita, Kazuo Umezawa, Sanetoshi Yamada, Yoshiro Yamamoto, Hayato Miyachi
OBJECTIVES: To control carbapenem-resistant Pseudomonas aeruginosa, we implemented a hospital-wide policy concerning the selective use of carbapenems based on the monitoring of P. aeruginosa isolates for susceptibility to five carbapenems using a customized dry plate method. In this study, we retrospectively investigated the outcome of our measures to control carbapenem-resistant P. aeruginosa. METHODS: To select effective carbapenems, 100 clinical isolates were collected, and the minimum inhibitory concentration (MIC) to 5 carbapenems (IPM/CS, MEPM, DRPM, BIPM and PAPM/BP) was monitored using a customized dry plate method from 2006 to 2013...
December 20, 2017: Tokai Journal of Experimental and Clinical Medicine
Atsushi Wada, Mitsutomo Kohno, Kana Oiwa, Ryo Hashimoto, Takahisa Koizumi, Yusuke Nakamura, Tomoki Nakagawa, Ryota Masuda, Kichizo Kaga, Masayuki Iwazaki
OBJECTIVES: Ischemia-reperfusion injury resulting in post-transplant lung dysfunction involves a complicated network of cytokines that has yet to be fully investigated. We analyzed temporal changes in cytokine levels in epithelial lining fluid (ELF) from the distal airways of a canine lung transplantation model. METHODS: Ischemic time was set to 18 hours to enhance lung injury in a left single-lung transplantation model. ELF was collected via bronchoscopic microsampling, a minimally-invasive technique allowing repeated sampling, hourly up to 5 hours after reperfusion started...
December 20, 2017: Tokai Journal of Experimental and Clinical Medicine
Hiroyuki Furuya
The first domestic outbreak of dengue fever in Japan since 1945 was reported in Tokyo in 2014. Meanwhile, daily mean summer temperatures are expected to continue to rise world-wide. Such conditions are expected to increase the risk of an arbovirus outbreak at the 2020 Tokyo Olympic Games. To address this possibility, the present study compared estimates of the risk of infection by dengue, chikungunya, and Zika viruses in urban areas. To compare the risk of infection by arboviruses transmitted by Ae. albopictus mosquitoes, the reproduction number for each of three arboviruses was estimated under the environmental conditions associated with the 2014 dengue outbreak in Tokyo, and additionally under conditions assuming a daily mean temperature elevation of 2° C...
December 20, 2017: Tokai Journal of Experimental and Clinical Medicine
Hideki Ozawa, Akiko Taoda, Takuma Shinoda, Hidetaka Yanagi, Masayuki Oki, Atsushi Takagi
The patient was a 32-year-old man with a previous history of bronchial asthma. He was admitted with chief complaints of dyspnea and skin rash associated with itching of the palms and soles of the feet, which began 2 weeks earlier. Because of the presence of cardiac failure and increase in the peripheral blood eosinophil count, eosinophilic myocarditis (EM) was suspected. His blood pressure gradually decreased and the patient went into cardiogenic shock. Therefore, endomyocardial biopsy was performed and was immediately followed by corticosteroid therapy and intra-aortic balloon pump (IABP) placement...
December 20, 2017: Tokai Journal of Experimental and Clinical Medicine
Mayako Terao, Naoki Niikura, Yasuhiro Suzuki, Norihiko Sengoku, Hitoshi Arioka, Takashi Ishikawa, Koichiro Tsugawa, Yutaka Tokuda
OBJECTIVE: Many different options for adjuvant chemotherapy are recommended in guidelines for the treatment of breast cancer. Therapeutic strategies vary among physicians. The major goals for this project were to gain a better understanding of how biomarkers are integrated into practice and how physicians select adjuvant chemotherapy. METHODS: We assembled a questionnaire with 23 example scenarios of breast cancer cases, including 6 items relevant to postoperative adjuvant therapy...
December 20, 2017: Tokai Journal of Experimental and Clinical Medicine
Hideki Ozawa, Kousuke Kuwano, Saki Manabe, Toru Ishihara, Masamichi Komatsu, Takako Kobayashi, Hidetaka Yanagi, Masayuki Oki, Atsushi Takagi
The patient was a previously healthy 23-year-old woman who made an outpatient visit to our hospital's Department of General Internal Medicine after developing pain and edema of the lower legs a week earlier. The patient was diagnosed with eosinophilic cellulitis (EC) based on an increased eosinophil count of 5,418/mm3 and the results of a skin biopsy of the lower leg that showed eosinophilic infiltration of the dermal tissue. Her condition improved after oral prednisone therapy. EC presents clinically as edema and eosinophilia...
December 20, 2017: Tokai Journal of Experimental and Clinical Medicine
Takashi Kasahara, Saori Ikeda, Ayaka Sugimoto, Shinji Sugawara, Yuji Koyama, Minoru Toyokura, Yoshihisa Masakado
BACKGROUND: Mirror feedback rehabilitation is effective in preventing the development of oro-ocular synkinesis following severe facial palsy. However, we do not have effective maneuvers to prevent the deterioration of oculo-oral synkinesis. We developed a new method of biofeedback rehabilitation using tape for the prevention of oculo-oral synkinesis. OBJECTIVE: The aim of the present study was to investigate the efficacy of taping feedback rehabilitation. METHODS: Twelve consecutive patients with peripheral facial nerve palsy who developed synkinesis were divided into 2 groups...
September 20, 2017: Tokai Journal of Experimental and Clinical Medicine
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