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Current Problems in Cancer

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https://www.readbyqxmd.com/read/28104314/breast-prostate-and-thyroid-cancer-screening-tests-and-overdiagnosis
#1
Minsoo Jung
The purpose of this study was to examine overdiagnosis and overtreatment related to cancer screening and to review relevant reports and studies. A comprehensive search of peer-reviewed and gray literature was conducted for relevant studies published between January 2000 and December 2015 reporting breast, prostate, and thyroid cancer screening tests and overdiagnosis. This study revealed no dichotomy on where screening would lower risk or cause overdiagnosis and overtreatment. Many screening tests did both, that is, at population level, there were both benefit (decreased disease-specific mortality) and harm (overdiagnosis and overtreatment)...
December 20, 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/28088330/genomic-insights-in-gynecologic-cancer
#2
Erika Roddy, Jocelyn Chapman
Recent technological advances in DNA sequencing have enabled a remarkably detailed understanding of the molecular changes that define gynecologic and other cancers. Several groups have carried out large-scale genomic analyses of ovarian, uterine, and most recently, cervical cancer. These analyses have led to new insights into the molecular changes characterizing these cancers, which provide insight into clinical outcomes. These molecular characterizations have similarly led to new genomic-based classification schemas, which may better stratify clinical outcomes, help prognosticate and guide treatments...
November 11, 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/28041631/targeting-fibroblast-growth-factor-pathways-in-endometrial-cancer
#3
Boris Winterhoff, Gottfried E Konecny
Novel treatments that improve outcomes for patients with recurrent or metastatic endometrial cancer (EC) remain an unmet need. Aberrant signaling by fibroblast growth factors (FGFs) and FGF receptors (FGFRs) has been implicated in several human cancers. Activating mutations in FGFR2 have been found in up to 16% of ECs, suggesting an opportunity for targeted therapy. This review summarizes the role of the FGF pathway in angiogenesis and EC, and provides an overview of FGFR-targeted therapies under clinical development for the treatment of EC...
November 11, 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/28017343/knowledge-of-cancer-symptoms-and-anxiety-affect-patient-delay-in-seeking-diagnosis-in-patients-with-heterogeneous-cancer-locations
#4
Gabriela Chojnacka-Szawłowska, Mikołaj Majkowicz, Krzysztof Basiński, Agata Zdun-Ryżewska, Iwona Wasilewko, Piotr Pankiewicz
PURPOSE: This research was aimed at identifying factors that predict patient delay in treatment initiation in patients with suspected cancer disease. We sought to determine the differences between delaying and nondelaying patients with reference to their knowledge of cancer symptoms, sociodemographic variables, and the levels of state anxiety and trait anxiety. METHODS: The study involved 301 randomly selected patients with suspected cancer disease before their first oncology appointment at a regional oncology center in Poland...
October 31, 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/27993186/amyloidosis-a-rare-disease-with-varied-manifestations
#5
EDITORIAL
Beata Holkova
No abstract text is available yet for this article.
September 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/27979324/amyloidosis-and-its-management-amyloid-neuropathies
#6
REVIEW
Kathleen Thornton Pearson, Scott Vota
No abstract text is available yet for this article.
September 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/27855962/evaluation-of-health-related-quality-of-life-and-its-main-influencing-factors-in-a-polish-population-of-patients-with-bone-metastases
#7
Mirosława Püsküllüoğlu, Aneta L Zygulska, Iwona M Tomaszewska, Sebastian Ochenduszko, Kamil Konopka, Krzysztof A Tomaszewski
PURPOSE: Regardless of cancer type, the skeleton is one of the most common sites for cancer spread. Health-related Quality of Life (HRQoL) can be considered a primary endpoint in clinical trials concerning cancer patients with palliative disease. The proper measurement of this endpoint requires valid and reliable instruments. The aim of this study was to evaluate HRQoL and its main influencing factors using validated EORTC tools - the QLQ-C30 and the QLQ-BM22 in Polish population of patients with skeletal metastases...
September 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/27839745/palliative-care-and-symptom-management-in-amyloidosis-a-review
#8
REVIEW
Jessica Tsukanov, Egidio Del Fabbro
No abstract text is available yet for this article.
September 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/27765403/renal-amyloidosis
#9
REVIEW
Jason Kidd, Daniel E Carl
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September 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/27520848/toxicities-associated-with-head-and-neck-cancer-treatment-and-oncology-related-clinical-trials
#10
REVIEW
Alessandro Villa, Stephen Sonis
No abstract text is available yet for this article.
September 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/27320011/giving-another-chance-to-mifepristone-in-pharmacotherapy-for-aggressive-meningiomas-a-likely-synergism-with-hydroxyurea
#11
REVIEW
İlhan Elmaci, Meric A Altinoz, Aydin Sav, Zeliha Yazici, Aysel Ozpinar
No abstract text is available yet for this article.
September 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/27855963/immunotherapy-in-breast-cancer-an-overview-of-modern-checkpoint-blockade-strategies-and-vaccines
#12
REVIEW
Katherine Sanchez, David Page, Heather L McArthur
Immune therapy has recently emerged as a standard-of-care strategy for the treatment of melanoma, lung cancer, bladder cancer, among other malignancies. However, the role of immune therapy in the treatment of breast cancer is still being determined. Two current strategies for harnessing the immune system to treat cancer include drugs that modulate key T cell inhibitory checkpoints and vaccines. Specifically, modern immune therapy strategies can facilitate T-cell mediated tumor regression by priming the immune system against specific tumor associated antigens, by modulating immunoregulatory signals, or both...
March 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/27839747/endocrine-therapy-and-strategies-to-overcome-therapeutic-resistance-in-breast-cancer
#13
REVIEW
Michael Robert Mancuso, Suleiman Alfred Massarweh
Despite the remarkable success of endocrine therapy in the treatment of patients with estrogen receptor (ER)- positive breast cancer, not all patients derive benefit from such therapy, or may benefit only temporarily before disease progression or relapse occurs. The value of endocrine therapy, which blocks ER signaling by a variety of strategies, lies in its simplicity, lower toxicity, and better alignment with preserved quality of life, particularly when compared to chemotherapy, which is more toxic and has only modest benefits for many patients with ER-positive breast cancer...
March 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/27839746/metastatic-human-epidermal-growth-factor-receptor-2-positive-breast-cancer-management-challenges-and-future-directions
#14
REVIEW
Mohsin Soleja, Mothaffar F Rimawi
HER2 is over-expressed or amplified in 15-20% of breast cancer. Significant progress has been made in the treatment of metastatic HER2+ breast cancer. This is largely due to successful targeting of the HER2 pathway. There are several approved agents in the metastatic setting. However, treatment resistance frequently develops and tumors eventually progress. In recent years, our understanding of mechanisms of resistance has evolved. It is generally accepted now that HER2-positive breast cancer is not one disease...
March 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/27816190/targeting-the-androgen-receptor-in-triple-negative-breast-cancer
#15
REVIEW
Ayca Gucalp, Tiffany A Traina
Triple-negative breast cancer represents approximately 15%-20% of all newly diagnosed breast cancers, but it accounts for a disproportionate number of breast cancer-related deaths each year. Owing to the lack of estrogen, progesterone, and human epidermal growth factor receptor 2 expression, patients with triple-negative breast cancer do not benefit from generally well-tolerated and effective therapies targeting the estrogen and human epidermal growth factor receptor 2 signaling pathways and are faced with an increased risk of disease progression and poorer overall survival...
March 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/27816189/systemic-therapy-for-her2-positive-early-stage-breast-cancer
#16
REVIEW
Aju Mathew, Edward H Romond
The advent of the targeted monoclonal antbody trastuzumab for treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer marked a revolution in the understanding and management of mammary carcinoma and, in practice, separated this subtype from other kinds of primary breast malignancy. Long term follow-up from the initial large adjuvant trials continue to show remarkably positive results. Currently, at least four additional agents targeting this receptor, using different and complementary mechanisms of action compared with trastuzumab, have been incorporated into clinical trials...
March 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/27793424/special-considerations-in-the-evaluation-and-management-of-breast-cancer-in-men
#17
REVIEW
Suleiman Alfred Massarweh, Gloria L Choi
Breast cancer in men is relatively uncommon but its incidence has been rising. Traditionally, the management of breast cancer in men is based on extrapolation from clinical trials of breast cancer in women, due to the much more extensive data available in women with this disease. There are, however, unique characteristics that distinguish breast cancer in men and these should be taken into consideration when managing this patient population. Breast cancer in men is more frequently estrogen receptor (ER) and progesterone receptor (PgR) positive, and less frequently HER2 amplified...
March 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/27793423/introduction-to-special-issue-on-breast-cancer
#18
Suleiman Alfred Massarweh
No abstract text is available yet for this article.
March 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/26948478/foreword
#19
Sungjune Kim
No abstract text is available yet for this article.
January 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/26656977/clinical-trials-exploring-the-benefit-of-immunotherapy-and-radiation-in-cancer-treatment-a-review-of-the-past-and-a-look-into-the-future
#20
REVIEW
Arash Olyie Naghavi, Peter A S Johnstone, Sungjune Kim
Cancer immunotherapy is rapidly redefining the standard of cancer care. The role of radiation therapy in eliciting antitumoral immune response is also being actively investigated in combination with various immunotherapeutic agents to exploit potential synergy between the 2 modalities. In this review, we summarize the rationale and results of past and ongoing clinical trials that combined the use of radiation therapy and immunogenic agents such as vaccines, cytokines, immune checkpoint inhibitors, costimulatory agonists, and myeloid activators...
January 2016: Current Problems in Cancer
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