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Current Problems in Cancer

Varsha Singh, Prerna Guleria, Prabhat Singh Malik, Anant Mohan, Sanjay Thulkar, R M Pandey, Kalpana Luthra, Sudheer Arava, Ruma Ray, Deepali Jain
Mitogen-Activated Protein (MAP) Kinase pathway involves several oncogenic genes which can serve as potential targets for therapy. Therefore, aim of the present study is to analyze mutations in the MAP Kinase pathway in pulmonary adenocarcinoma (ADCA) of Indian patients along with clinico-pathologic correlation and determination of the survival status in patients receiving therapy. Blocks and slides of 125 pulmonary ADCA of last 5 years were retrieved. Histo-morphology and tumor content were determined. EGFR, KRAS, BRAF and MEK1 genes were analyzed using Sanger sequencing and Real-time polymerase chain reaction (PCR)...
December 17, 2018: Current Problems in Cancer
Manish Sharma, Ajay Gogia, Suryanarayana S V Deo, Sandeep Mathur
Alteration of biomarkers is well-documented in breast cancer at locoregional recurrence or metastasis attributed to tumor heterogeneity and change in biology. There is a lack of literature on alteration of biomarkers in metastatic breast cancer (MBC) at progression. We included 32 patients of upfront MBC. Estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2/neu documented at baseline and at progression. Median age was 46 (range 26-72) years. Estrogen receptor altered in 6 (18...
December 10, 2018: Current Problems in Cancer
Ryan C Pickens, Amit V Sastry, Dionisios Vrochides, David A Iannitti
No abstract text is available yet for this article.
December 3, 2018: Current Problems in Cancer
Erik Kudela, Marcela Nachajova, Tomas Balharek, Eva Gabonova, Jan Danko
Mullerian adenosarcoma with sarcomatous overgrowth (MASO) of the uterine cervix is an extremely rare variant of adenosarcoma of the genital tract associated with aggressive clinical course. We searched the PubMed and Medline databases for MASO of the cervix and we identified and reviewed eleven cases published between years 2004 and 2017. The most common clinical picture includes abnormal vaginal bleeding, postcoital bleeding, pelvic pain and foul-smelling vaginal discharge. Therapeutic options for MASO are still undefined...
November 30, 2018: Current Problems in Cancer
Jingjing Xia, Hong Li, Yaling Ji, Can Mi, Guilian Chen, Ping Li, Ruirui Zhang, Wei Chen, Jipeng Wang
Patients aged ≤45 years are rarely diagnosed as lung cancer. Therefore, this paper describes a retrospective study which was conducted to understand the clinicopathologic characteristics and epidermal growth factor receptor (EGFR) mutations in these young lung cancer patients. All patients diagnosed as lung cancer from January 2014 to December 2016 at Huai'an First People's Hospital were enrolled in this study. Their clinicopathologic manifestations and EGFR mutations were recorded, and the difference between those aged less than 45 years and those aged above 45 years was compared...
November 28, 2018: Current Problems in Cancer
Michael Morton, Nelya Melnitchouk, Ronald Bleday
No abstract text is available yet for this article.
November 23, 2018: Current Problems in Cancer
Murat Araz, Mustafa Karaagac, Levent Korkmaz, Ismail Beypinar, Mukremin Uysal
PURPOSE: We aimed to investigate the compliance of Turkish Medical Oncologists to antiemetic guidelines for treatment of acute and delayed chemotherapy-induced nausea and vomiting (CINV) in patients receiving high (HEC), moderate (MEC), and low (LEC) emetogenic chemotherapy. METHOD: A covering electronic mail letter with an online questionnaire link was sent to e-mail and mobile application groups including all 599 members of the Turkish Society of Medical Oncology in January 2018...
November 22, 2018: Current Problems in Cancer
Bernardo Cacho-Díaz, Héctor Spínola-Maroño, Laura G Mendoza-Olivas
BACKGROUND AND PURPOSE: Cancer and stroke are the second and third causes of death worldwide; brain metastases (BM) occur in one third of patients with cancer, any neurologic deficit in these population always prompts the clinician to discard metastases for their presence carries a bad outcome. Both might share clinical presentation and differences in their outcome are not entirely known. The aim was to compare risk factors, clinical presentation, and outcome of cancer patients with BM vs stroke...
November 16, 2018: Current Problems in Cancer
Paolo Cariati, Almudena Cabello-Serrano, Fernando Monsalve-Iglesias, Jose Fernadez-Solis, Ildefonso Martinez-Lara
PURPOSE: The main aim of the present study is to analyze the behavior of squamous cell carcinoma (SCC) of maxillary gingiva, alveolus, and hard palate and to determine the utility of selective neck dissection in clinically N0 patients at early stages. MATERIAL AND METHOD: Twenty-nine previously untreated patients with SCC of maxillary gingiva, alveolus, and hard palate were diagnosed and treated with at least a tumorectomy and selective neck dissection at HUVN and included in the study...
November 12, 2018: Current Problems in Cancer
Hala Mohammad Ali Yousif, Rabab Ahmed Ahmed Mohammed
Alteration of expression of the tumor suppressor gene BRCA-1 has been widely studied in breast and ovarian carcinoma. However, pattern of this alteration in the benign-borderline-carcinoma sequence in serous and mucinous ovarian neoplasms have not yet fully described. Tissue sections from 214 formalin-fixed paraffin-embedded ovarian specimens were stained immunohistochemically with BRCA-1 antibody. Specimens were 10 normal ovarian surface epithelium, 10 fallopian tube epithelium, 70 benign adenoma (50 serous and 20 mucinous), 28 borderline (13 serous and 15 mucinous), 78 carcinoma (58 serous and 20 mucinous), and 18 metastatic deposit (13 serous and 5 mucinous)...
November 6, 2018: Current Problems in Cancer
Simona Picchia, Monica Terlizzo, Maria Antonietta Bali
No abstract text is available yet for this article.
November 6, 2018: Current Problems in Cancer
Shahanaze J, Jayachandran S, Madhusmita M, Soundravally R
Pleural effusion is a common presenting feature of malignancy. Malignant pleural effusion is primarily diagnosed by pleural fluid cytology, pleural biopsy, and tumor markers. The glycoprotein YKL-40 is a new tumor marker that has shown to have a good diagnostic accuracy to detect malignant pleural effusion. However, there are only a few studies that have evaluated pleural fluid YKL-40 for detecting malignant pleural effusions. Hence, we conducted this study to evaluate the utility of pleural fluid YKL-40 to detect malignant pleural effusion...
November 3, 2018: Current Problems in Cancer
Stephanie Wills, Lana K Hochmuth, Kenneth S Bauer, Rahul Deshmukh
Until a recent introduction to checkpoint inhibitors, there were limited second-line chemotherapy options for urothelial carcinoma (UC) patients with disease progression after first-line, platinum-based treatment. Outcomes for patients with advanced disease over the past 30 years have highlighted a need for new and better therapy. In response to evolving interest, durvalumab (MEDI4736) was introduced as a potential treatment for advanced stages of UC. Durvalumab is a selective, high-affinity, human IgG1 kappa monoclonal antibody engineered with a triple mutation to reduce toxicity...
September 18, 2018: Current Problems in Cancer
Yuyang Zhang, Dan Zhang, Lin Zhao, Lili Sun, Qiguan Dong, Li Cheng, Rixia Cheng
Although several published studies have investigated the association between p53 Arg72Pro polymorphism and the risk of colorectal cancer (CRC), their results have been ambiguous. To examine the overall relationship between published case-control studies of Asian subjects, we conducted a meta-analysis based on 13 studies. Databases PubMed, EMBASE, Web of Knowledge, and the Chinese National Knowledge Infrastructure were screened for studies carried out up to November 1, 2017. To evaluating the association, crude odds ratios (ORs) with 95% confidence intervals (95% CI) were calculated...
September 8, 2018: Current Problems in Cancer
Na Wang, Kai Wang, Ya-Ting Liu, Fei-Xue Song
The purpose of this review was to compare the efficacy and safety of everolimus plus endocrine therapy with endocrine therapy for hormone receptor-positive, human epidermal growth factor 2 negative advanced breast cancer patients. We comprehensively searched the PubMed, the Cochrane Library, EMBASE, Web of Science, Chinese biomedicine literature database, WanFang Data, CNKI, and VIP database for relevant articles. The retrieval time limit is from building the database to July 2018. The computer search was supplemented with a manual search of reference lists for all available review articles...
September 7, 2018: Current Problems in Cancer
Yu-Sheng Li, Qing Liu, Hong-Bo He, Wei Luo
Osteosarcoma (OS) is a common malignant tumor of bone, of which clear understanding of molecular pathologic process is not yet possible. Insulin-like growth factor-1 (IGF-1) is a hormone that plays vital role in development and function of many tissues. Unfortunately, IGF-1 and its receptor (IGF-1R)'s over-expression have been implicated in carcinogenesis, and indicated to constitute a risk factor for the development of multiple human cancers, including OS. Increased levels of IGF-1 and IGF-1R have been reported in OS, leading to cancer progression through transformation, proliferation, pro-metastasis, and decreased susceptibility to apoptosis...
September 7, 2018: Current Problems in Cancer
Minako Saito, Hidenori Kage, Takahiro Ando, Ryoko Sawada, Yosuke Amano, Yasushi Goto, Yusuke Shinoda, Takahide Nagase
According to lung cancer guidelines, positron emission tomography scan is recommended for initial evaluation of bone metastasis. However, guidelines differ in their recommendations for when it should be used. We investigated the appropriate use of bone imaging in nonsmall cell lung cancer (NSCLC) patients. One hundred seventy-seven consecutive NSCLC patients who had distant metastases at presentation and were admitted between January 2012 and April 2016 were retrospectively reviewed. Among patients with bone metastases, we explored bone pain, number of bone metastases, location of bone metastases, and clinical tumor (T) and lymph node (N) classification...
September 4, 2018: Current Problems in Cancer
Muneer J Al-Husseini, Hadeer H Mohamed, Anas M Saad, Mohamed M Gad, Mona Atia, Umniyah Qaddoora, Abdelrahman Ibrahim Abushouk, Mohamed E Elshinawi
BACKGROUND: We aimed to investigate the risk and survival of chronic myeloid leukemia (CML) after breast cancer (BC) diagnosis. METHODS: We used the Surveillance, Epidemiology, and End Results 'SEER' database. Females, diagnosed with BC between 1992 and 2014, were selected and followed for the development of CML after a 6-month latency period from BC diagnosis. We used the Multiple Primary Standardized Incidence Ratios session of the SEER*Stat software (version 8...
September 3, 2018: Current Problems in Cancer
Anthony E Rizzo, Sarah Feldman
In the coming decade, primary testing for human papillomavirus (HPV) will likely become the standard of care for cervical cancer screening in both low- and high-resource settings. This change comes as evidence has accumulated to support HPV testing as more sensitive to detect high-grade precancerous disease. Furthermore, negative HPV testing has demonstrated a lower cumulative incidence of cervical intraepithelial neoplasia (CIN) grade 3 or worse pathology (CIN3+) when compared to negative "Pap smears" over several rounds of screening...
September 2018: Current Problems in Cancer
Beatriz Wills, Egal Gorse, Valerie Lee
Colorectal cancer (CRC) is the third most common cancer worldwide, with a global incidence of over 1 million cases. In the era of personalized medicine, tumor sampling is essential for characterizing the molecular profile of individual tumors. This provides pivotal information regarding optimal sequencing of therapy and emergence of drug resistance, allowing for timely therapy adjustment. However, tumor tissue sampling offers static information in a single time point and area of disease at the time of biopsy, which may not entirely represent the heterogeneity of molecular alterations...
August 29, 2018: Current Problems in Cancer
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