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https://www.readbyqxmd.com/read/29349537/timing-of-spirometry-may-impact-hospital-length-of-stay-for-cystic-fibrosis-pulmonary-exacerbation
#1
Katelyn Krivchenia, Dmitry Tumin, Christopher J Nemastil, Joseph D Tobias, Don Hayes
PURPOSE: The optimal timing of spirometry during hospitalization for acute pulmonary exacerbation (PEx) in patients with cystic fibrosis (CF) is unclear. We retrospectively evaluated whether measuring spirometry earlier during hospitalization was associated with a shorter length of stay (LOS). METHODS: In this retrospective study, we analyzed data from the electronic medical record of CF patients 6 years of age and older admitted to a single center for acute PEx requiring IV antibiotic therapy between 2009 and 2016...
January 18, 2018: Lung
https://www.readbyqxmd.com/read/29349536/oxygen-uptake-efficiency-slope-and-prediction-of-post-operative-morbidity-and-mortality-in-patients-with-lung-cancer
#2
Sertaç Yakal, Sevtün Sofyalı, Berker Özkan, Safinaz Yıldız, Alper Toker, Erdem Kasikcioglu
OBJECTIVE: Peak oxygen consumption is a very valuable cardiopulmonary functional parameter in pre-operative evaluation of patients with lung cancer. However, it has several critical limitations for operability decision due to failure in achieving maximal level of exercise test for cases. The aim of this study was to reveal the importance of more accurate cardiopulmonary parameters that can be calculated from data of submaximal level test, such as oxygen uptake efficiency slope (OUES) and to determine whether it could be used in the operability decision phase for borderline cases by means of morbidity and mortality...
January 18, 2018: Lung
https://www.readbyqxmd.com/read/29349535/mycobacterium-xenopi-genotype-associated-with-clinical-phenotype-in-lung-disease
#3
Takashi Hirama, Alex Marchand-Austin, Jennifer Ma, David C Alexander, Sarah K Brode, Theodore K Marras, Frances B Jamieson
Mycobacterium xenopi is responsible for pulmonary disease (PD) in Europe and Canada. Despite its high prevalence and increasing clinical importance, little is known about the genetic diversity of M. xenopi. Through a prospective study for M. xenopi strain type and the relation to clinical phenotype, 39 patients with M. xenopi PD were analyzed. Our study demonstrated that sequence type (ST) 5 was dominant in Ontario among 15 distinct STs and caused PD in people even without underlying lung disease, whereas disease due to non-ST5 was found almost exclusively in patients with underlying lung disease...
January 18, 2018: Lung
https://www.readbyqxmd.com/read/29299681/concerns-about-lung-cancer-among-prisoners
#4
Luc Renault, Emmanuel Perrot, Eric Pradat, Christophe Bartoli, Laurent Greillier, Anne Remacle-Bonnet, Norbert Telmon, Julien Mazières, Laurent Molinier, Sébastien Couraud
BACKGROUND: Few studies have looked at lung cancer in prisoners, despite this population is possibly at increased risk of malignancy. In a previous study, we found an early onset of lung cancer in prisoners. Thus, the present CARCAN study was aimed at assessing the epidemiological characteristics, management, prognosis, and incidence of lung cancer in prisoners compared to a sample of non-prisoner patients. METHOD: We performed a multi-center observational case-control study...
January 3, 2018: Lung
https://www.readbyqxmd.com/read/29275453/inhaled-treprostinil-in-pulmonary-hypertension-associated-with-lung-disease
#5
Mariana Faria-Urbina, Rudolf K F Oliveira, Manyoo Agarwal, Aaron B Waxman
PURPOSE: Pulmonary hypertension (PH) in the setting of parenchymal lung disease adversely affects quality of life and survival. However, PH-specific drugs may result in ventilation/perfusion imbalance and currently, there are no approved PH treatments for this patient population. In the present retrospective study, data from 22 patients with PH associated with lung disease treated with inhaled treprostinil (iTre) and followed up clinically for at least 3 months are presented. METHODS: PH was defined by resting right heart catheterization as a mean pulmonary artery pressure (mPAP) ≥ 35 mmHg, or mPAP ≥ 25 mmHg associated with pulmonary vascular resistance ≥ 4 Woods Units...
December 23, 2017: Lung
https://www.readbyqxmd.com/read/29273833/prospective-observational-study-on-the-association-between-serum-mannose-binding-lectin-levels-and-severe-outcome-in-critically-ill-patients-with-pandemic-influenza-type-a-h1n1-infection
#6
Elie Zogheib, Remy Nyga, Marjorie Cornu, Boualem Sendid, Julien Monconduit, Vincent Jounieaux, Julien Maizel, Christine Segard, Taïeb Chouaki, Hervé Dupont
BACKGROUND: Mannose-binding lectin (MBL) plays an important role in the innate immune response. In addition to activating the complement, MBL can induce cytokine production and contribute to a deleterious inflammatory response with severe A(H1N1)pdm09 virus infection. Our aim was to determine if serum MBL levels correlate with the risk of mortality in intensive care units (ICU) patients with A(H1N1)pdm09 infection. METHODS: Prospective observational study was performed in ICU patients with acute respiratory distress syndrome due to influenza A(H1N1)pdm09 virus...
December 22, 2017: Lung
https://www.readbyqxmd.com/read/29264652/intratracheal-administration-of-autologous-bone-marrow-derived-cells-ameliorates-monocrotaline-induced-pulmonary-vessel-remodeling-and-lung-inflammation-in-rats
#7
Yoriko Yamazato, Masanobu Yamazato, Akio Ishida, Jiro Fujita, Yusuke Ohya
PURPOSE: Inflammation is a feature of lung injury and plays a critical role in pulmonary vascular remodeling. Bone marrow-derived cells (BMCs) have anti-inflammatory properties and favor macrophage differentiation into an alternatively activated regulatory M2 profile. We investigated the effect of autologous BMCs on monocrotaline-induced pulmonary vessel remodeling and lung inflammation in rats, by direct administration into lungs via the airway. METHODS: BMCs were isolated and plastic-adherent cells were cultured for 3 weeks...
December 20, 2017: Lung
https://www.readbyqxmd.com/read/29264651/sensitivity-of-lung-resistance-and-compliance-to-beta-blocker-induced-bronchoconstriction-and-long-acting-beta-agonist-withdrawal-in-copd
#8
Sunny Jabbal, Brian J Lipworth
Little is known about impulse oscillometry (IOS) in COPD. IOS is an effort independent measure of lung resistance and reactance (compliance). We assessed how frequency dependence of resistance (R) and reactance (X) changed in response to bronchoconstriction with carvedilol followed by long acting beta-agonist (LABA) withdrawal. N = 12 patients with moderate to severe COPD were analysed, who had ≥ 100 ml fall in FEV1 with carvedilol. Compared to baseline taking ICS/LABA there were 21, 59, and 135% significant changes in resistance at 5 Hz (R5), reactance at 5 Hz (X5), and reactance area (AX), respectively, with carvedilol, while after LABA withdrawal only AX showed a further significant increase to 210% (i...
December 20, 2017: Lung
https://www.readbyqxmd.com/read/29260309/hiv-infection-pulmonary-tuberculosis-and-copd-in-rural-uganda-a-cross-sectional-study
#9
Crystal M North, Joseph G Allen, Samson Okello, Ruth Sentongo, Bernard Kakuhikire, Edward T Ryan, Alexander C Tsai, David C Christiani, Mark J Siedner
PURPOSE: HIV is associated with chronic obstructive pulmonary disease (COPD) in high resource settings. Similar relationships are less understood in low resource settings. We aimed to estimate the association between HIV infection, tuberculosis, and COPD in rural Uganda. METHODS: The Uganda Non-communicable Diseases and Aging Cohort study observes people 40 years and older living with HIV (PLWH) on antiretroviral therapy, and population-based HIV-uninfected controls in rural Uganda...
December 19, 2017: Lung
https://www.readbyqxmd.com/read/29234869/a-controlled-trial-of-inhaled-bronchodilators-in-familial-dysautonomia
#10
Bat-El Bar-Aluma, Ori Efrati, Horacio Kaufmann, Jose-Alberto Palma, Lucy Norcliffe-Kaufmann
BACKGROUND: Chronic lung disease is a leading cause of premature death in patients with familial dysautonomia (FD). A significant number of patients have obstructive airway disease, yet it is not known whether this is pharmacologically reversible. METHODS: We conducted a double-blind, placebo-controlled, randomized clinical trial comparing the beta 2 agonist albuterol with the muscarinic blocker ipratropium bromide in patients homozygous for the IKBKAP founder mutation...
December 12, 2017: Lung
https://www.readbyqxmd.com/read/29230534/the-burden-of-comorbidity-and-complexity-in-sarcoidosis-impact-of-associated-chronic-diseases
#11
Pilar Brito-Zerón, Nihan Acar-Denizli, Antoni Sisó-Almirall, Xavier Bosch, Fernanda Hernández, Sergi Vilanova, Mireia Villalta, Belchin Kostov, Marina Paradela, Marcelo Sanchez, José Ramírez, Africa Muxí, Antonio Berruezo, Celeste Galceran-Chaves, Antoni Xaubet, Carles Agustí, Jacobo Sellarés, Manuel Ramos-Casals
PURPOSE: To evaluate comorbidity, complexity and poor outcomes in patients with sarcoidosis and to compare those scores with a control group. METHODS: 218 consecutive patients were diagnosed with sarcoidosis according to the ATS/ERS/WASOG criteria; extrathoracic involvement was evaluated using the 2014 WASOG organ assessment instrument. Sarcoidosis patients were compared with an age- and gender-matched control group of primary care outpatients without sarcoidosis...
December 11, 2017: Lung
https://www.readbyqxmd.com/read/29222599/cigarette-smoke-induces-activation-of-polymorphonuclear-leukocytes
#12
Anita Somborac-Bačura, Sanja Popović-Grle, Vlasta Zovko, Tihana Žanić-Grubišić
INTRODUCTION: Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD). Exposure to cigarette smoke may stimulate inflammatory response and activate polymorphonuclear leukocytes (PMN) thus resulting in secretion of cellular proteases. The aim of our study was to explore the effect of cigarette smoke extract (CSE) on the release of matrix metalloproteinase-9 (MMP-9) from PMN. METHODS: The study included 23 patients with stable COPD and 9 healthy controls...
December 8, 2017: Lung
https://www.readbyqxmd.com/read/29218399/lung-image-doege-potter-syndrome
#13
Sami Karapolat, Kubra Nur Seyis, Alaaddin Buran, Atila Turkyilmaz, Safak Ersoz, Celal Tekinbas
No abstract text is available yet for this article.
December 7, 2017: Lung
https://www.readbyqxmd.com/read/29204685/methylene-blue-protects-the-isolated-rat-lungs-from-ischemia-reperfusion-injury-by-attenuating-mitochondrial-oxidative-damage
#14
Wen-Fang Tian, Si Zeng, Qiong Sheng, Jun-Liang Chen, Ping Weng, Xiao-Tong Zhang, Jia-Jia Yuan, Qing-Feng Pang, Zhi-Qiang Wang
INTRODUCTION: Impaired mitochondrial function is a key factor attributing to the lung ischemia reperfusion injury (LIRI). Methylene blue (MB) has been reported to attenuate brain and renal ischemia-reperfusion injury. We hypothesized that MB also could have a protective effect against LIRI by preventing mitochondrial oxidative damage. METHODS: Isolated rat lungs were assigned to the following four groups (n = 6): a sham group: perfusion for 105 min without ischemia; I/R group: shutoff of perfusion and ventilation for 45 min followed by reperfusion for 60 min; and I/R + MB group and I/R + glutathione (GSH) group: 2 mg/kg MB or 4 μM glutathione were intraperitoneally administered for 2 h, and followed by 45 min of ischemia and 60 min of reperfusion...
December 4, 2017: Lung
https://www.readbyqxmd.com/read/29177539/does-feno-predict-clinical-characteristics-in-chronic-cough
#15
Mahboobeh Haji Sadeghi, Caroline E Wright, Simon Hart, Michael Crooks, Alyn H Morice
PURPOSE: To evaluate whether exhaled nitric oxide measurement can facilitate in the assessment of chronic cough patients based on their airway inflammatory phenotype. METHODS: We have studied consecutive patients attending a specialist cough clinic. 30 patients with high FeNO (> 30 ppb) and 20 patients with low FeNO (< 20 ppb) were recruited. RESULTS: There was a significant correlation between FeNO, B-Eos and sputum eosinophil count (p < 0...
November 25, 2017: Lung
https://www.readbyqxmd.com/read/29147774/assessment-of-mediastinal-lymph-node-size-in-pneumococcal-pneumonia-with-bacteremia
#16
Amit Chopra, Aakash Modi, Haroon Chaudhry, Recai Yucel, Neha Rane, John Fantauzzi, Frederic J Hellwitz, Marc A Judson
INTRODUCTION: The significance of mediastinal lymphadenopathy in bacterial pneumonia is unclear. METHODS: We performed a retrospective analysis of mediastinal lymph node size determined by chest CT in patients with bacteremic pneumococcal pneumonia. All patients who had positive blood cultures for streptococcus pneumonia over an 11-year period and had a chest CT scan (index CT) within 2 weeks of the positive blood culture were included in the study. Two thoracic radiologists and one pulmonologist independently examined the index CT plus any chest CT scans performed prior (pre-CT) or after (post-CT) the bacteremic episode...
November 16, 2017: Lung
https://www.readbyqxmd.com/read/29143119/infectious-and-non-infectious-diseases-causing-the-air-crescent-sign-a-state-of-the-art-review
#17
REVIEW
Joyce Betta Sevilha, Rosana Souza Rodrigues, Miriam Menna Barreto, Gláucia Zanetti, Bruno Hochhegger, Edson Marchiori
Aspergilloma, also known as mycetoma or fungus ball, is characterized by a round or oval mass with soft-tissue attenuation within a preexisting lung cavity. The typical computed tomography (CT) aspect of an aspergilloma is a mass separated from the wall of the cavity by an airspace of variable size and shape, resulting in the air crescent sign, also known as the meniscus sign. This CT feature is non-specific and can be simulated by several other entities that result in intracavitary masses. This review describes the main clinical and imaging aspects of the infectious and non-infectious diseases that may present with fungus-ball appearance, including pulmonary hydatid cyst, Rasmussen aneurysm, pulmonary gangrene, intracavitary clot, textiloma, lung cancer, metastasis, and teratoma, focusing on the differential diagnosis...
November 15, 2017: Lung
https://www.readbyqxmd.com/read/29134264/oxygen-desaturation-in-daily-life-and-during-a-laboratory-based-protocol-of-activities-of-daily-living-in-copd-is-there-relationship
#18
Thaís Sant'Anna, Leila Donária, Nidia A Hernandes, Karina C Furlanetto, Décio S Barbosa, Rik Gosselink, Fabio Pitta
PURPOSE: To analyze the relationship between oxygen desaturation episodes during a laboratory-based ADL protocol and in real-life routine in patients with stable chronic obstructive pulmonary disease (COPD). METHODS: Twenty patients with stable COPD (12 men, 70 ± 7 years, FEV1% 54 ± 15 predicted) with no indication for long-term oxygen therapy (LTOT) were submitted to assessments including ADL performance by the Londrina ADL Protocol (LAP) and level of physical activity in daily life, both while submitted to simultaneous activity and pulse oximeter monitoring...
November 13, 2017: Lung
https://www.readbyqxmd.com/read/29134263/diminished-susceptibility-of-african-americans-to-non-tuberculous-mycobacterial-disease
#19
Jerome M Reich, Jong S Kim
The incidence of three granulomatous response diseases-sarcoidosis, tuberculosis, and non-tuberculous mycobacterial pulmonary disease-differ markedly in African-Americans versus Caucasians. In reviewing a large compendium of non-cystic-fibrosis bronchiectasis, we noted that complicating infection with non-tuberculous mycobacteria was relatively infrequent among individuals of African-American descent, confirming previous observations of their inherent resistance. Disease-specific variance among African-Americans in the efficacy of their granulomatous response suggests a nexus, a mediating, immunological mechanism...
November 13, 2017: Lung
https://www.readbyqxmd.com/read/29080069/5-aminosalicylic-acid-modulates-the-immune-response-in-chronic-beryllium-disease-subjects
#20
Brian J Day, Jie Huang, Briana Q Barkes, May Gillespie, Li Li, Lisa A Maier
INTRODUCTION: Chronic beryllium disease (CBD) is characterized by accumulation of macrophages and beryllium-specific CD4(+) T cells that proliferate and produce Th1 cytokines. 5-Amino salicylic acid (5-ASA) is currently used to treat inflammatory bowel disease and has both antioxidant and anti-inflammatory actions. We hypothesized that 5-ASA may be a beneficial therapeutic in CBD. METHODS: Seventeen CBD patients were randomized 3:1 to receive 5-ASA 500-mg capsules or placebo four times daily for 6 weeks orally...
October 27, 2017: Lung
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