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https://www.readbyqxmd.com/read/29147774/assessment-of-mediastinal-lymph-node-size-in-pneumococcal-pneumonia-with-bacteremia
#1
Amit Chopra, Aakash Modi, Haroon Chaudhry, Recai Yucel, Neha Rane, John Fantauzzi, Frederic J Hellwitz, Marc A Judson
INTRODUCTION: The significance of mediastinal lymphadenopathy in bacterial pneumonia is unclear. METHODS: We performed a retrospective analysis of mediastinal lymph node size determined by chest CT in patients with bacteremic pneumococcal pneumonia. All patients who had positive blood cultures for streptococcus pneumonia over an 11-year period and had a chest CT scan (index CT) within 2 weeks of the positive blood culture were included in the study. Two thoracic radiologists and one pulmonologist independently examined the index CT plus any chest CT scans performed prior (pre-CT) or after (post-CT) the bacteremic episode...
November 16, 2017: Lung
https://www.readbyqxmd.com/read/29143119/infectious-and-non-infectious-diseases-causing-the-air-crescent-sign-a-state-of-the-art-review
#2
REVIEW
Joyce Betta Sevilha, Rosana Souza Rodrigues, Miriam Menna Barreto, Gláucia Zanetti, Bruno Hochhegger, Edson Marchiori
Aspergilloma, also known as mycetoma or fungus ball, is characterized by a round or oval mass with soft-tissue attenuation within a preexisting lung cavity. The typical computed tomography (CT) aspect of an aspergilloma is a mass separated from the wall of the cavity by an airspace of variable size and shape, resulting in the air crescent sign, also known as the meniscus sign. This CT feature is non-specific and can be simulated by several other entities that result in intracavitary masses. This review describes the main clinical and imaging aspects of the infectious and non-infectious diseases that may present with fungus-ball appearance, including pulmonary hydatid cyst, Rasmussen aneurysm, pulmonary gangrene, intracavitary clot, textiloma, lung cancer, metastasis, and teratoma, focusing on the differential diagnosis...
November 15, 2017: Lung
https://www.readbyqxmd.com/read/29134264/oxygen-desaturation-in-daily-life-and-during-a-laboratory-based-protocol-of-activities-of-daily-living-in-copd-is-there-relationship
#3
Thaís Sant'Anna, Leila Donária, Nidia A Hernandes, Karina C Furlanetto, Décio S Barbosa, Rik Gosselink, Fabio Pitta
PURPOSE: To analyze the relationship between oxygen desaturation episodes during a laboratory-based ADL protocol and in real-life routine in patients with stable chronic obstructive pulmonary disease (COPD). METHODS: Twenty patients with stable COPD (12 men, 70 ± 7 years, FEV1% 54 ± 15 predicted) with no indication for long-term oxygen therapy (LTOT) were submitted to assessments including ADL performance by the Londrina ADL Protocol (LAP) and level of physical activity in daily life, both while submitted to simultaneous activity and pulse oximeter monitoring...
November 13, 2017: Lung
https://www.readbyqxmd.com/read/29134263/diminished-susceptibility-of-african-americans-to-non-tuberculous-mycobacterial-disease
#4
Jerome M Reich, Jong S Kim
The incidence of three granulomatous response diseases-sarcoidosis, tuberculosis, and non-tuberculous mycobacterial pulmonary disease-differ markedly in African-Americans versus Caucasians. In reviewing a large compendium of non-cystic-fibrosis bronchiectasis, we noted that complicating infection with non-tuberculous mycobacteria was relatively infrequent among individuals of African-American descent, confirming previous observations of their inherent resistance. Disease-specific variance among African-Americans in the efficacy of their granulomatous response suggests a nexus, a mediating, immunological mechanism...
November 13, 2017: Lung
https://www.readbyqxmd.com/read/29080069/5-aminosalicylic-acid-modulates-the-immune-response-in-chronic-beryllium-disease-subjects
#5
Brian J Day, Jie Huang, Briana Q Barkes, May Gillespie, Li Li, Lisa A Maier
INTRODUCTION: Chronic beryllium disease (CBD) is characterized by accumulation of macrophages and beryllium-specific CD4(+) T cells that proliferate and produce Th1 cytokines. 5-Amino salicylic acid (5-ASA) is currently used to treat inflammatory bowel disease and has both antioxidant and anti-inflammatory actions. We hypothesized that 5-ASA may be a beneficial therapeutic in CBD. METHODS: Seventeen CBD patients were randomized 3:1 to receive 5-ASA 500-mg capsules or placebo four times daily for 6 weeks orally...
October 27, 2017: Lung
https://www.readbyqxmd.com/read/29043487/the-differences-in-spirometry-predictive-equations-in-classifying-presence-and-degree-of-lung-function-impairment-which-suit-fits-the-best
#6
Marija Vukoja, Aleksandar Bokan, Gordana Vujasinovic, Ivan Kopitovic
PURPOSE: The aim of this study was to compare the differences between three most commonly used predictive equations (PE): ECCS (European Community of Coal and Steel), the third National Health and Nutrition Examination Survey (NHANES III), and GLI (Global Lung Initiative) in healthy individuals and when grading severity of lung function impairment in patients with obstructive lung diseases. METHODS: The study included 200 healthy volunteers and 200 patients with obstructive lung diseases at the Institute for Pulmonary Diseases of Vojvodina...
October 17, 2017: Lung
https://www.readbyqxmd.com/read/29030687/tolerability-of-bisoprolol-on-domiciliary-spirometry-in-copd
#7
Sunny Jabbal, Brian J Lipworth
We investigated if serial domiciliary measures of spirometry were sensitive at detecting subtle effects of beta-2 blockade associated with bisoprolol in (n = 17) patients with COPD. After a two-week run in on inhaled corticosteroid (ICS) and long acting beta-2 agonist (LABA): beclometasone/formoterol 100/6 µg, patients' started additional a long acting muscarinic receptor antagonist: (LAMA) Tiotropium 18 µg, with concomitant weekly dose titration of bisoprolol: 1.25-2.5-5 mg. After a further week of bisoprolol 5 mg, they were stepped back down to (ICS/LABA) for one week...
October 14, 2017: Lung
https://www.readbyqxmd.com/read/29026982/severe-hemoptysis-associated-with-bacterial-pulmonary-infection-clinical-features-significance-of-parenchymal-necrosis-and-outcome
#8
Guillaume Carteaux, Damien Contou, Guillaume Voiriot, Antoine Khalil, Marie-France Carette, Martine Antoine, Antoine Parrot, Muriel Fartoukh
PURPOSE: Severe hemoptysis (SH) associated with non-tuberculosis bacterial lower respiratory tract infection (LRTI) is poorly described, and the efficacy of the usual decision-making process is unknown. This study aimed at describing the clinical, radiological patterns, mechanism, and microbiological spectrum of SH related to bacterial LRTI, and assessing whether the severity of hemoptysis and the results of usual therapeutic strategy are influenced by the presence of parenchymal necrosis...
October 12, 2017: Lung
https://www.readbyqxmd.com/read/28993877/anxiety-depression-and-health-related-qol-in-patients-diagnosed-with-pah-or-cteph
#9
Elena Pfeuffer, Holger Krannich, Michael Halank, Heinrike Wilkens, Philipp Kolb, Berthold Jany, Matthias Held
BACKGROUND: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are life-threatening diseases with a high burden of symptoms. Although depression, anxiety, and reduced health related quality of life (HRQOL) have also been reported, a comparative analysis which explores these traits and their underlying factors was lacking. METHODS: A retrospective analysis of depression, anxiety, and health related QOL was conducted using a Hospital anxiety and depression scale (HADS) as well as the SF-36 HRQOL questionnaire...
October 9, 2017: Lung
https://www.readbyqxmd.com/read/28914352/impact-of-physical-activity-on-reporting-of-childhood-asthma-symptoms
#10
Benedicta Nneoma Nnodum, Meredith C McCormack, Nirupama Putcha, Seungyoung Hwang, Laura M Paulin, Emily P Brigham, Ashraf Fawzy, Karina Romero, Gregory B Diette, Nadia N Hansel
This study aims to determine the impact of physical activity on asthma symptom reporting among children living in an inner city. Among 147 children aged 5-12 years with physician-diagnosed asthma, we assessed asthma symptoms using twice-daily diaries and physical activity using the physical activity questionnaire for children during three 8-day periods (baseline, 3 and 6 months). Linear, logistic, and quasi-poisson regression models were used to determine the association between physical activity and asthma symptoms; adjusting for age, sex, race, BMI, caregiver's education, asthma severity, medication use, and season...
September 15, 2017: Lung
https://www.readbyqxmd.com/read/28849295/diet-and-respiratory-health-in-children-from-11-latin-american-countries-evidence-from-isaac-phase-iii
#11
Alfonso Mario Cepeda, Sumaiyya Thawer, Robert J Boyle, Sara Villalba, Rodolfo Jaller, Elmy Tapias, Ana María Segura, Rodrigo Villegas, Vanessa Garcia-Larsen
BACKGROUND AND AIM: The burden of childhood asthma and its risk factors is an important but neglected public health challenge in Latin America. We investigated the association between allergic symptoms and dietary intake in children from this region. METHODS: As part of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase III, questionnaire collected dietary intake was investigated in relation to risk of parental/child reported current wheeze (primary outcome) and rhino-conjunctivitis and eczema...
August 28, 2017: Lung
https://www.readbyqxmd.com/read/29058073/the-rare-complication-and-diagnostic-challenges-of-pulmonary-eosinophilia-in-graft-versus-host-disease-patients-after-hematopoietic-stem-cell-transplantation
#12
Pierre Tawfik, Patrick Arndt
PURPOSE: Chronic graft versus host disease (cGvHD) is a common complication of hematopoietic stem cell transplantation (HSCT). Eosinophilic lung disease is a rare poorly understood complication in HSCT patients with cGvHD. These patients present similarly to those with Acute Eosinophilic Pneumonia (AEP). The purpose of this study is to better elucidate the presentation and potential treatment of this phenomenon. METHODS: We reviewed over 170 bronchoscopies in post-HSCT patients with respiratory symptoms...
December 2017: Lung
https://www.readbyqxmd.com/read/29032479/-pulmonary-vein-sign-for-pulmonary-embolism-diagnosis-in-computed-tomography-angiography
#13
Luciana Volpon Soares Souza, Matheus Zanon, Arthur Soares Souza, Klaus Irion, Diana Penha, Giordano Rafael Tronco Alves, Edson Marchiori, Bruno Hochhegger
PURPOSES: Considering that pulmonary arterial obstruction decreases venous flow, we hypothesized that filling defects in pulmonary veins can be identified in areas adjacent to pulmonary embolism (PE). This sign was named the "pulmonary vein sign" (PVS), and we evaluated its prevalence and performance for PE diagnosis in computed tomography pulmonary angiography (CTPA). METHODS: This retrospective study enrolled consecutive patients with clinical suspicion of PE who underwent CTPA scan...
December 2017: Lung
https://www.readbyqxmd.com/read/29022070/surgical-resection-for-pulmonary-carcinoid-long-term-results-of-multicentric-study-the-importance-of-pathological-n-status-more-than-we-thought
#14
Giacomo Cusumano, Ludovic Fournel, Salvatore Strano, Diane Damotte, Marie Christine Charpentier, Antonio Galia, Alberto Terminella, Maurizio Nicolosi, Jean Francois Regnard, Marco Alifano
BACKGROUND: Histological subdivision into typical (TC) and atypical (AC) is crucial for treatment and prognosis of lung carcinoids but can be also very challenging, even for experts. In this study, we aimed to strengthen or reduce the prognostic value of several pathological, clinical, or per-operative factors some of which are still controversial. METHODS: We retrospectively reviewed clinical records related to 195 patients affected by TC (159) or AC (36) surgically treated between 2000 and 2014, in three different centers...
December 2017: Lung
https://www.readbyqxmd.com/read/28993936/the-influence-of-body-composition-on-pulmonary-rehabilitation-outcomes-in-chronic-obstructive-pulmonary-disease-patients
#15
Pichapong Tunsupon, M Jeffery Mador
INTRODUCTION: Alterations in body composition are commonly present in chronic obstructive pulmonary disease (COPD). The hypothesis of this study is that COPD patients would achieve clinical benefits after pulmonary rehabilitation (PR) independent of muscle mass depletion or body weight. METHODS: We conducted a retrospective cohort study using single-frequency bioelectrical impedance analysis (BIA) for assessment of fat-free mass (FFM) depletion (muscle depletion)...
December 2017: Lung
https://www.readbyqxmd.com/read/28993933/gamma-glutamyltransferase-and-future-risk-of-pneumonia-a-long-term-prospective-cohort-study
#16
Setor K Kunutsor, Jari A Laukkanen
Serum gamma-glutamyltransferase (GGT) has been linked with the risk of adverse health outcomes. We aimed to assess the prospective association of GGT activity with pneumonia risk. Serum GGT was measured at baseline in 2400 middle-aged men. Within-person variability in GGT values was corrected for using data from repeat measurements. During a median follow-up of 25.3 years, 409 pneumonia cases were recorded. The age-adjusted regression dilution ratio of GGT was 0.68 (95% CI 0.63-0.73). Gamma-glutamyltransferase was approximately log-linearly associated with pneumonia risk...
December 2017: Lung
https://www.readbyqxmd.com/read/28993879/accuracy-of-diagnostic-coding-for-sarcoidosis-in-electronic-databases-a-population-based-study
#17
Patompong Ungprasert, Eric L Matteson, Cynthia S Crowson
PURPOSE: Epidemiologic study of sarcoidosis utilizing electronic databases has been increasingly popular. However, the accuracy of diagnostic codes for sarcoidosis is unknown. METHODS: The medical record-linkage system of the Rochester Epidemiology Project was searched to identify all potential adult cases of sarcoidosis between January 1, 1995 and December 31, 2013 in Olmsted County, Minnesota, using the International Classification of Diseases, Ninth Revision (ICD-9) code 135 (sarcoidosis)...
December 2017: Lung
https://www.readbyqxmd.com/read/28993876/il-8-gene-variants-and-expression-in-childhood-asthma
#18
Rihab Charrad, Wajih Kaabachi, Ahlem Rafrafi, Anissa Berraies, Kamel Hamzaoui, Agnes Hamzaoui
PURPOSE: To examine the IL-8 expression levels and association of genetic variants with the risk of childhood persistent asthma prognosis. METHODS: Overall, 170 asthmatic children and 170 healthy controls were included in this case-control study. The human IL-8 serum levels were measured using ELISA. The IL-8 mRNA expression levels were assessed by a real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods...
December 2017: Lung
https://www.readbyqxmd.com/read/28993871/dual-bronchodilation-with-indacaterol-maleate-glycopyrronium-bromide-compared-with-umeclidinium-bromide-vilanterol-in-patients-with-moderate-to-severe-copd-results-from-two-randomized-controlled-cross-over-studies
#19
Edward Kerwin, Gary T Ferguson, Shahin Sanjar, Thomas Goodin, Anthony Yadao, Robert Fogel, Samopriyo Maitra, Biswajit Sen, Tim Ayers, Donald Banerji
PURPOSE: To compare the efficacy and safety of two long-acting dual bronchodilator combinations: indacaterol/glycopyrrolate (IND/GLY) versus umeclidinium/vilanterol (UMEC/VI). METHODS: Studies A2349 and A2350 were replicate, randomized, double-blind, double-dummy, active-controlled, cross-over studies in patients with moderate-to-severe COPD. Patients were randomized to sequential 12-week treatments of twice-daily IND/GLY 27.5/15.6 μg and once-daily UMEC/VI 62...
December 2017: Lung
https://www.readbyqxmd.com/read/28900718/prognosis-of-cancer-with-synchronous-or-metachronous-malignant-pleural-effusion
#20
José M Porcel, Cristina Solé, Antonieta Salud, Silvia Bielsa
PURPOSE: Malignant pleural effusions (MPE) may either coincide with or follow the diagnosis of a primary tumor. Whether this circumstance influences prognosis has not been well substantiated. METHODS: Retrospective review of all consecutive patients who were cared for at a Spanish university hospital during an 11-year period and received a diagnosis of MPE. RESULTS: Of 401 patients, the MPE was the first evidence of cancer in 265 (66%), and it followed a previously diagnosed neoplasm in 136 (34%)...
December 2017: Lung
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