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https://www.readbyqxmd.com/read/27915422/state-of-the-art-review-of-the-right-ventricle-in-copd-patients-it-is-time-to-look-closer
#1
REVIEW
Daniela Graner Schuwartz Tannus-Silva, Marcelo Fouad Rabahi
Since the first description of pulmonary circulation in the 16th century, the knowledge of the complex interaction between the heart and lungs has greatly improved. Hypoxemia plays a classical role in the development of complications such as pulmonary hypertension and right ventricle (RV) dysfunction in patients presenting with chronic obstructive pulmonary disease (COPD). However, more recent results have revealed the presence of RV vascular structural and functional changes even in patients with mild COPD, without hypoxemia or pulmonary hypertension at rest...
December 3, 2016: Lung
https://www.readbyqxmd.com/read/27900466/overview-of-the-impact-of-depression-and-anxiety-in-chronic-obstructive-pulmonary-disease
#2
Josep Montserrat-Capdevila, Pere Godoy, Josep Ramon Marsal, Ferran Barbé, Josep Pifarré, Miquel Alsedà, Marta Ortega
BACKGROUND: Anxiety and depression are common entities in patients diagnosed with COPD. However, the impact that they have on the exacerbation of illness is scarcely studied. OBJECTIVE: To determine if the presence of anxiety and depression is associated with a greater risk of frequent exacerbation (≥2 per year) in patients diagnosed with COPD. PATIENTS AND METHODS: A cohort study that analysed frequent exacerbation and associated factors in 512 patients monitored during 2 years...
November 29, 2016: Lung
https://www.readbyqxmd.com/read/27900465/polymorphisms-in-beta-2-adrenergic-receptor-gene-and-association-with-tuberculosis
#3
Abbas Farzin Azar, Nima Hosseini Jazani, Ahad Bazmani, Ali Vahhabi, Shahram Shahabi
PURPOSE: Genetic susceptibility for tuberculosis in human has been previously demonstrated. Polymorphisms in genes involved in immune responses may alter the susceptibility of individuals to tuberculosis. Polymorphisms of beta-2 adrenergic receptor (ADRB2) gene can be possibly an important risk factor in tuberculosis. In this study, the association between rs1042713 (Arg16Gly +46A>G) and rs1042714 (Gln27Glu +79C>G) polymorphisms in ADRB2 gene and tuberculosis was evaluated. METHODS: Genotype distributions of the rs1042713 (Arg16Gly +46A>G) and rs1042714 (Gln27Glu +79C>G) polymorphisms in ADRB2 gene in 106 patients with pulmonary tuberculosis and 88 healthy subjects were studied by PCR-RFLP method in an Iranian population...
November 29, 2016: Lung
https://www.readbyqxmd.com/read/27888398/the-value-of-the-electrocardiogram-for-evaluating-prognosis-in-patients-with-idiopathic-pulmonary-arterial-hypertension
#4
Xiao-Ling Cheng, Jian-Guo He, Zhi-Hong Liu, Qing Gu, Xin-Hai Ni, Zhi-Hui Zhao, Qin Luo, Chang-Ming Xiong
BACKGROUND: Association between electrocardiography (ECG) features and right ventricular anatomy and physiology has been established. This study is aimed to identify the value of 12-lead ECG in evaluating prognosis of patients with idiopathic pulmonary arterial hypertension (IPAH). METHOD: 194 patients with newly diagnosed IPAH were included in this study. Correlations between electrocardiography variables and hemodynamics were assessed. Univariate and multivariable cox regression analysis were performed to identify ECG variables for predicting all-cause mortality in IPAH...
November 25, 2016: Lung
https://www.readbyqxmd.com/read/27866277/identification-of-key-cost-generating-events-for-idiopathic-pulmonary-fibrosis-a-systematic-review
#5
REVIEW
Shalvaree Vaidya, Clare L Hibbert, Elizabeth Kinter, Stefan Boes
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is an incurable, debilitating disease which impairs lung function and eventually leads to death. Currently, there is a lack of effective modifying therapies and treatments for IPF as the underlying epidemiological mechanism is not clearly understood. This leads to difficulty in diagnosing and managing IPF, which results in a high incurment of disease-associated cost. Even though IPF poses a substantial economic burden, there is a lack of research available on cost triggers and healthcare utilization, which can be a barrier to future economic evaluations of new medicines for IPF...
November 19, 2016: Lung
https://www.readbyqxmd.com/read/27866276/manual-intrapleural-saline-flushing-plus-urokinase-a-potentially-useful-therapy-for-complicated-parapneumonic-effusions-and-empyemas
#6
José M Porcel, Horacio Valencia, Silvia Bielsa
PURPOSE: We sought to evaluate the safety profile and effectiveness of manual pleural saline flushing, in addition to urokinase, for managing complicated parapneumonic effusions and empyemas. METHODS: Retrospective comparative review of 23 consecutive patients with complicated parapneumonic effusions or empyemas who received saline flushing plus urokinase through small-bore chest catheters, and 39 who were only treated with fibrinolytics. Both groups had similar baseline characteristics and treatments were mostly protocol-driven...
November 19, 2016: Lung
https://www.readbyqxmd.com/read/27864635/soluble-cd200-correlates-with-interleukin-6-levels-in-sera-of-copd-patients-potential-implication-of-the-cd200-cd200r-axis-in-the-disease-course
#7
Priya Sakthivel, Angele Breithaupt, Marcus Gereke, David A Copland, Christian Schulz, Achim D Gruber, Andrew D Dick, Jens Schreiber, Dunja Bruder
BACKGROUND: COPD represents a multifactorial lung disorder with high morbidity and mortality. Despite intensive research concerning the underlying disease mechanisms, the involvement of the CD200/CD200R axis in supporting or preventing the onset of COPD has not yet been addressed. Since the CD200/CD200R axis is crucially implicated in the maintenance of pulmonary immune homeostasis, we hypothesized that it might be involved in controlling the onset of COPD. METHODS: To address this, we analyzed the serum samples from COPD patients and normal controls for soluble (s) CD200 and correlated the data to COPD-relevant clinical parameters...
November 18, 2016: Lung
https://www.readbyqxmd.com/read/27858160/assessing-the-therapeutic-response-to-pirfenidone-in-idiopathic-pulmonary-fibrosis-can-we-do-better-than-with-forced-vital-capacity-alone
#8
Karishma Hosein, Jamie Le, Marco Mura
New anti-fibrotic agents for idiopathic pulmonary fibrosis (IPF) were approved based on the results of forced vital capacity (FVC) trends, although concerns were raised about the reliability of FVC as the only endpoint parameter. We hypothesized that IPF-specific multi-dimensional scores (Composite Physiologic Index-CPI; gender-age-physiology-GAP; risk stratification score-RISE) would better capture response to therapy. In this pilot study, treated and untreated cohorts of IPF patients, matched for demographic and functional characteristics were prospectively followed for 1 year, at 4-month intervals...
November 17, 2016: Lung
https://www.readbyqxmd.com/read/27853876/impact-of-non-invasive-ventilation-on-sympathetic-nerve-activity-in-chronic-obstructive-pulmonary-disease
#9
Helge Haarmann, Jan Folle, Xuan Phuc Nguyen, Peter Herrmann, Karsten Heusser, Gerd Hasenfuß, Stefan Andreas, Tobias Raupach
PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with elevated sympathetic nerve activity, which is probably linked to an increased cardiovascular risk, and may contribute to muscle dysfunction by heightened muscle vasoconstrictor drive. We hypothesized that resistive unloading of respiratory muscles by intermittent non-invasive ventilation (NIV) reduces sympathetic tone at rest and during subsequent handgrip exercise in patients with COPD. METHODS: Muscle sympathetic nerve activity (MSNA) in the peroneal nerve, heart rate, blood pressure, CO2, and SpO2 were continuously recorded in 5 COPD patients with intermittent NIV and 11 control COPD patients without NIV...
November 16, 2016: Lung
https://www.readbyqxmd.com/read/27803970/the-maximal-expiratory-to-inspiratory-pressure-ratio-and-supine-vital-capacity-as-screening-tests-for-diaphragm-dysfunction
#10
Patrick Koo, Dennis O Oyieng'o, Eric J Gartman, Jigme M Sethi, Charles B Eaton, F Dennis McCool
PURPOSE: The change in vital capacity from the seated to supine position (∆VC-supine) is used to screen for diaphragm dysfunction (DD), but some individuals are unable to tolerate the supine position. Since expiratory muscle function is often preserved in patients with isolated DD and inspiratory strength is reduced, the purpose of this study was to examine if the ratio of maximal expiratory pressure to maximal inspiratory pressure (MEP/MIP) may provide an alternative to ∆VC-supine when screening patients for DD...
November 1, 2016: Lung
https://www.readbyqxmd.com/read/27803969/erratum-to-effects-of-twenty-days-of-the-ketogenic-diet-on-metabolic-and-respiratory-parameters-in-healthy-subjects
#11
Alessandro Rubini, Gerardo Bosco, Alessandra Lodi, Lorenzo Cenci, Andrea Parmagnani, Keith Grimaldi, Yang Zhongjin, Antonio Paoli
No abstract text is available yet for this article.
November 1, 2016: Lung
https://www.readbyqxmd.com/read/27787611/delirium-is-a-strong-predictor-of-mortality-in-patients-receiving-non-invasive-positive-pressure-ventilation
#12
Ka-Yee Chan, Linda S L Cheng, Ivan W C Mak, Shu-Wah Ng, Michael G C Yiu, Chung-Ming Chu
PURPOSE: Non-invasive positive pressure ventilation (NIPPV) has gained popularity over the years in the treatment of acute respiratory failure (ARF). Preliminary evidence suggests that delirium is an important factor contributing to NIPPV failure and death. This study was conducted to evaluate delirium and other associated factors of deaths in patients with ARF requiring the use of NIPPV. METHODS: A prospective observational study was conducted in a specialised NIPPV unit...
October 27, 2016: Lung
https://www.readbyqxmd.com/read/27770204/overnight-changes-in-lung-function-of-obese-patients-with-obstructive-sleep-apnoea
#13
Laszlo Kunos, Zsofia Lazar, Fruzsina Martinovszky, Adam D Tarnoki, David L Tarnoki, Daniel Kovacs, Bianka Forgo, Peter Horvath, Gyorgy Losonczy, Andras Bikov
PURPOSE: Obstructive sleep apnoea (OSA) is a prevalent disorder, characterised by collapse of the upper airways during sleep. The impact of sleep-disordered breathing on pulmonary function indices is however currently not well described. The aim of the study was to evaluate diurnal change in lung function indices in a cohort of patients with OSA and relate pulmonary function changes to disease severity. METHODS: 42 patients with OSA and 73 healthy control subjects participated in the study...
October 21, 2016: Lung
https://www.readbyqxmd.com/read/27770203/acknowledgment-of-reviewers-2015
#14
(no author information available yet)
No abstract text is available yet for this article.
October 21, 2016: Lung
https://www.readbyqxmd.com/read/27761647/the-pattern-of-elastic-fiber-breakdown-in-bleomycin-induced-pulmonary-fibrosis-may-reflect-microarchitectural-changes
#15
Xingjian Liu, Shuren Ma, Gerard Turino, Jerome Cantor
INTRODUCTION: Desmosine and isodesmosine (DID) are unique elastin crosslinks that may serve as biomarkers for elastic fiber degradation in chronic obstructive pulmonary disease. Previously, our laboratory found that the ratio of free to peptide-bound DID in bronchoalveolar lavage fluid (BALF) showed a significant positive correlation with the extent of airspace enlargement in an elastase model of pulmonary emphysema. To further evaluate this hypothesis, our laboratory measured this ratio in a bleomycin (BLM) model of pulmonary fibrosis, which involved different microarchitectural changes than those associated with pulmonary emphysema...
October 19, 2016: Lung
https://www.readbyqxmd.com/read/27752830/a-paradox-%C3%AE-klotho-levels-and-smoking-intensity
#16
Zoraida Verde, Jose M Rodríguez González-Moro, Luis M Chicharro, Luis Reinoso-Barbero, Fernando Bandrés, Félix Gómez-Gallego, Catalina Santiago
Reports regarding smoking differences in α-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule α-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected for the analysis. Serum levels of soluble α-klotho were significantly higher in heavy smokers (P < 0.001). These results are in agreement with the possibility that α-klotho acts as anti-inflammatory molecule and strengthen the hypothesis that an increase of serum levels of α-klotho might be a compensatory response to smoking stress in healthy population...
October 17, 2016: Lung
https://www.readbyqxmd.com/read/27738828/intermittent-hypoxia-contributes-to-the-lung-damage-by-increased-oxidative-stress-inflammation-and-disbalance-in-protease-antiprotease-system
#17
I Tuleta, F Stöckigt, U R Juergens, C Pizarro, J W Schrickel, G Kristiansen, G Nickenig, D Skowasch
INTRODUCTION: Intermittent hypoxia as a surrogate of obstructive sleep apnea is associated with different cardiovascular complications. However, the effects of intermittent hypoxia on the lung tissue are less known. Therefore, the aim of our present study was to investigate if intermittent hypoxia may influence oxidative stress, inflammation, and protease/antiprotease system in the lung. Additionally, potential protective properties of anti-inflammatory and anti-oxidative drugs have been evaluated...
October 13, 2016: Lung
https://www.readbyqxmd.com/read/27738827/prognostic-impact-of-node-spreading-pattern-in-surgically-treated-small-cell-lung-cancer-a-multicentric-analysis
#18
Giovanni Leuzzi, Filippo Lococo, Gabriele Alessandrini, Isabella Sperduti, Lorenzo Spaggiari, Federico Venuta, Erino A Rendina, Pierluigi M Granone, Cristian Rapicetta, Piero Zannini, Gaetano Di Rienzo, Maurizio Nicolosi, Francesco Facciolo
OBJECTIVE: Although surgery in selected small-cell lung cancer (SCLC) patients has been proposed as a part of multimodality therapy, so far, the prognostic impact of node-spreading pattern has not been fully elucidated. To investigate this issue, a retrospective analysis was performed. METHODS: From 01/1996 to 12/2012, clinico-pathological, surgical, and oncological features were retrospectively reviewed in a multicentric cohort of 154 surgically treated SCLC patients...
October 13, 2016: Lung
https://www.readbyqxmd.com/read/27738826/gender-differences-in-the-association-of-individual-and-contextual-exposures-with-lung-function-in-a-rural-canadian-population
#19
Bonnie Janzen, Chandima Karunanayake, Donna Rennie, William Pickett, Joshua Lawson, Shelley Kirychuk, Louise Hagel, Ambikaipakan Senthilselvan, Niels Koehncke, James Dosman, Punam Pahwa
INTRODUCTION: To investigate the association of individual and contextual exposures with lung function by gender in rural-dwelling Canadians. METHODS: A cross-sectional mail survey obtained completed questionnaires on exposures from 8263 individuals; a sub-sample of 1609 individuals (762 men, 847 women) additionally participated in clinical lung function testing. The three dependent variables were forced expired volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio...
October 13, 2016: Lung
https://www.readbyqxmd.com/read/27734159/clinical-significance-of-forced-oscillation-technique-for-evaluation-of-small-airway-disease-in-interstitial-lung-diseases
#20
Masashi Mikamo, Tomoyuki Fujisawa, Yoshiyuki Oyama, Masato Kono, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Hiromitsu Sumikawa, Takeshi Johkoh, Takafumi Suda
PURPOSE: Small airway disease (SAWD) in patients with interstitial lung disease (ILD) is often assessed by high-resolution computed tomography (HRCT). However, frequent HRCT examinations result in a high level of radiographic exposure. This study investigated the utility of the forced oscillation technique (FOT) to evaluate SAWD in patients with ILD. METHODS: Broadband FOT using a commercially available device (MostGraph-01) and pulmonary function tests (PFT) were performed in 90 patients with ILD...
October 12, 2016: Lung
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