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Sonia Rouatbi, Ines Ghannouchi, Helmi Bensaad
OBJECTIVE: To determine and explain the effect of age on exhaled nitric oxide values in North African healthy subjects aged from 5 to 83 years. DESIGN: Prospective cross-sectional study. METHODS: Volunteer children adults and elderly healthy subjects were included. A medical questionnaire was used to assess several subject characteristics. The levels of exhaled fraction of nitric oxide (FeNO) were measured by Medisoft HypAir FeNO method. Spirometry function test was done after the FeNO measurement...
January 14, 2019: Lung
Alexandre Franco Amaral, Martina Rodrigues de Oliveira, Olívia Meira Dias, Fábio Eiji Arimura, Carolina Salim Gonçalves Freitas, Milena Marques Pagliarelli Acencio, Vanessa Adélia de Alvarenga, Ronaldo Adib Kairalla, Carlos Roberto Ribeiro Carvalho, Bruno Guedes Baldi
INTRODUCTION: Serum vascular endothelial growth factor-D (VEGF-D) is a lymphangiogenic growth factor that is considered a valuable tool in the diagnosis of lymphangioleiomyomatosis (LAM). Previous studies have reported a wide variability in VEGF-D serum levels in LAM patients and it seems to be associated with pulmonary impairment and lymphatic involvement. METHODS: We conducted a cross-sectional study from 2009 to 2017 that evaluated VEGF-D serum levels in a cohort of LAM patients who were never treated with mTOR inhibitors and compared them to healthy age-matched volunteers...
January 8, 2019: Lung
M Mehrtash, J P Bakker, N Ayas
Obstructive sleep apnea (OSA) is a common disease which impacts quality of life, mood, cardiovascular morbidity, and mortality. Continuous positive airway pressure (CPAP) is the first-line treatment for patients with moderate to severe OSA. CPAP ameliorates respiratory disturbances, leading to improvements in daytime sleepiness, quality of life, blood pressure, and cognition. However, despite the high efficacy of this device, CPAP adherence is often sub-optimal. Factors including: socio-demographic/economic characteristics, disease severity, psychological factors, and side-effects are thought to affect CPAP adherence in OSA patients...
January 7, 2019: Lung
Hesham El-Samadony, Hassan M E Azzazy, Mohamed Awad Tageldin, Mahmoud E Ashour, Ibrahim M Deraz, Tarek Elmaghraby
PURPOSE: TB nanodiagnostics have witnessed considerable development. However, most of the published reports did not proceed beyond proof-of-concept. Our objectives are to evaluate the diagnostic accuracy of a novel nanogold assay in detecting patients with active pulmonary TB based on results of BACTEC MGIT (reference test), and to compare its clinical performance to combined use of sputum smear microscopy (SSM) with chest X-ray (CXR). METHODS: This is a case-control study that involved 20 active TB patients; 20 non-TB chest patients with a previous history of TB infection; 20 non-TB chest patients without a previous history of TB infection...
January 4, 2019: Lung
Ricardo L M Duarte, Marcelo F Rabahi, Tiago S Oliveira-E-Sá, Flavio J Magalhães-da-Silveira, Fernanda C Q Mello, David Gozal
PURPOSE: Obstructive sleep apnea (OSA) is a common condition characterized by repetitive collapse of the upper airways and intermittent oxygen desaturation, which may lead to airway inflammation. Here, we explored whether fractional exhaled nitric oxide (FeNO) levels provide a non-invasive screening tool of OSA. METHODS: Over a 3-month period, FeNO levels were measured in consecutive non-smoking patients referred for a sleep laboratory. All patients underwent full polysomnography...
January 2, 2019: Lung
Baruch Vainshelboim, Mordechai Reuven Kramer, Jonathan Myers, Avraham Unterman, Shimon Izhakian, Jose Oliveira
PURPOSE: To assess the prognostic value of the 8-foot-up-and-go test (8-FUGT) in pilot cohort of patients with idiopathic pulmonary fibrosis (IPF). METHODS: Thirty-four patients with IPF (68 ± 8 years) underwent 8-FUGT at baseline and were followed for up to 40 months. Receiver operating characteristics and age-adjusted Cox hazard ratios (HR) were analyzed for 8-FUGT, hospitalizations, and mortality. Correlation coefficients were determined between 8-FUGT and other exercise tests...
January 2, 2019: Lung
Traci N Adams, Chad A Newton, Craig S Glazer
No abstract text is available yet for this article.
December 14, 2018: Lung
Susana Herrera Lara, Estrella Fernández-Fabrellas, Gustavo Juan Samper, Josefa Marco Buades, Rafael Andreu Lapiedra, Amparo Pinilla Moreno, María Morales Suárez-Varela
BACKGROUND: Malignant pleural effusion (MPE) is a sign of advanced disease of poor prognosis. As natural killer (NK) cells are involved in the first line of tumour defence, we aimed to validate a new diagnostic and prognostic indicator for MPE based on NK subpopulations of pleural fluid (PF) and peripheral blood (PB). METHODS: NK subpopulations were determined in PF and PB in 71 patients with malignant, paramalignant or benign pleural effusion. The receiver operating characteristic (ROC) curves, Kaplan-Meier, multivariable Cox model and decision trees created with the CHAID (Chi-square automatic interaction detector) methodology were employed...
December 6, 2018: Lung
Imran H Iftikhar, Mathew Schimmel, William Bender, Colin Swenson, David Amrol
No abstract text is available yet for this article.
December 5, 2018: Lung
Don Hayes, Ashley E Nance, Heidi M Mansour
No abstract text is available yet for this article.
December 3, 2018: Lung
N B Gunsoy, D J Bratton, R Alfonso-Cristancho
No abstract text is available yet for this article.
November 30, 2018: Lung
José M Porcel, Irene Cuadrat, Tomás García-Cerecedo, Marina Pardina, Silvia Bielsa
PURPOSE: Pleural effusion (PEs) may complicate diffuse large B-cell lymphomas (DLBCL). However, their real prevalence and prognostic significance have seldom been approached systematically. METHODS: Retrospective single-center evaluation of consecutive patients with DLBCL was conducted. Baseline characteristics, PEs on CT imaging, pleural fluid analyses, and outcome until death or censoring date were collected. RESULTS: Of 185 DLBCL patients, 55 (30%) had PEs, of which 27 (49%) were analyzed...
November 30, 2018: Lung
Jesse Vance, Andres Santos, Laura Sadofsky, Alyn Morice, Jorge Cervantes
PURPOSE: Diabetes mellitus (DBM) reduces immunological activity and increases susceptibility to various infections, including tuberculosis (TB). Human alveolar macrophage (hAM) functions are altered in DBM. METHODS: To mimic hyperglycemic conditions in the lung alveolus, we co-cultured a hAM cell line (Daisy cell line) with human umbilical vein endothelial cells for 48 h in the presence of culture media alone, normal glucose (5 mM), and high glucose (22 mM). Using flow cytometry, immunophenotype characterization included cell surface markers CD 11c, CD14, CD16, CD86, CD163, CD169, CD206, CX3CR-1, CSF-1R, and matrix metalloproteinase-9 (MMP9)...
November 24, 2018: Lung
Barak Pertzov, Elitsur Brachfeld, Avraham Unterman, Evgeni Gershman, Nader Abdel-Rahman, Dror Rosengarten, Mordechai Reuven Kramer
PURPOSE: There is clinical significance to a delay in response time for detecting desaturation by pulse oximetry. Our aim in this study was to compare the response time of the reflectance and transmittance saturation probes during fiberoptic bronchoscopy (FOB) under monitored anesthesia care. METHODS: A prospective study included 104 patients scheduled for FOB. Patients were monitored with transmittance (finger) and reflectance (ear) oximetry probes. The response time was evaluated during desaturation and resaturation...
November 24, 2018: Lung
David Bennett, Antonella Fossi, Giuseppina Chiarello, Rosa Metella Refini, Luca Luzzi, Piero Paladini, Maria Materozzi, Natale Figura, Ranuccio Nuti, Paola Rottoli
BACKGROUND: Helicobacter pylori (HP) is a spiral, gram-negative, microaerophilic bacterium that colonises the human gastric mucosa and is associated with gastrointestinal and extragastrointestinal disorders. Since no data are yet available on HP infection in lung transplant patients, we evaluated the prevalence and impact of HP infection in a population of such patients. METHODS: Sixty-seven lung transplant patients were enrolled in the study (35 females and 32 males, age 48...
November 19, 2018: Lung
Abdulrahman Almadani, Melissa N Y Ping, Anu Deenadayalu, Jean Saunders, Aidan O'Brien
BACKGROUND: Transbronchial lung biopsy (TBBX) is a common respiratory diagnostic procedure performed to investigate several lung diseases. There are different types of forceps used to perform this procedure. The alligator and cupped (oval) forceps are most commonly used ones. To date, there are few studies that have compared the efficacy of these two types of forceps. This study compares the two types of forceps relating to the rate of complications and diagnostic value. METHODS: In this retrospective observational study, 40 patients who underwent TBBX using the alligator forceps were compared to a previous group of 40 patients who underwent the same procedure using the cupped forceps...
November 15, 2018: Lung
Rafaella F Xavier, Ana Carolina A C Pereira, Aline C Lopes, Vinícius Cavalheri, Regina M C Pinto, Alberto Cukier, Ercy M C Ramos, Celso R F Carvalho
INTRODUCTION: People with chronic obstructive pulmonary disease (COPD) present high prevalence of physical inactivity that leads to a negative effect on health-related quality of life (HRQoL). The present study investigated COPD phenotypes according to their levels of physical activity and sedentary behaviour, as well as body composition and skeletal muscle strength. METHODS: This is an observational and cross-sectional study. Anthropometric data and COPD clinical control were collected and all participants underwent assessments of lung function, HRQoL, dyspnoea, levels of physical activity and sedentary behaviour, body composition and skeletal muscle strength...
November 14, 2018: Lung
Bryn Rosser-Stanford, Karianne Backx, Rachel Lord, Edgar Mark Williams
PURPOSE: While the static and dynamic lung volumes of active swimmers is often greater than the predicted volume of similarly active non-swimmers, little is known if their ventilatory response to exercise is also different. METHODS: Three groups of anthropometrically matched male adults were recruited, daily active swimmers (n = 15), daily active in fields sport (Rugby and Football) (n = 15), and recreationally active (n = 15). Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1 ), and maximal voluntary ventilation (MVV) was measured before and after exercise to volitional exhaustion...
November 2, 2018: Lung
Wendong Hao, Manxiang Li, Cailian Zhang, Yunqing Zhang, Yani Xue
OBJECTIVE: The purpose of this study was to investigate the relationship between serum fractalkine (CX3CL1/FKN) level and the multi-slice spiral computed tomography (MSCT) emphysema index in Chinese patients with chronic obstructive pulmonary disease (COPD). METHODS: We detected chemokine CX3CL1 in serum from 95 Chinese patients with COPD by using an enzyme-linked immunosorbent assay. According to the MSCT emphysema index, the selected cases were divided into an emphysema-dominant group (n = 25) and a non-emphysema-dominant group (n = 70)...
October 31, 2018: Lung
Larissa Martinez, Diego Rodrigues, Leila Donária, Karina C Furlanetto, Felipe Vilaça Cavallari Machado, Lorena Paltanin Schneider, Marcos Ribeiro, Nidia A Hernandes, Fabio Pitta
The aim of the study was to investigate the relationship between slow and forced vital capacity (SVC-FVC) difference with dynamic lung hyperinflation (DH) during the 6-min walking test (6MWT) in subjects with chronic obstructive pulmonary disease (COPD). Twenty-four subjects with COPD (12 males; 67 ± 6 years; forced expiratory volume in first second [FEV1 ] 56 ± 18% predicted) performed lung function tests by spirometry and plethysmography. DH was assessed by serial measurements of inspiratory capacity (IC) performed during the 6MWT and defined as ∆IC ≥ 150 mL or 10%...
October 29, 2018: Lung
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