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Journal of Bioenergetics and Biomembranes

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https://www.readbyqxmd.com/read/29243009/adrenaline-induces-mitochondrial-biogenesis-in-rat-liver
#1
Gaetana Napolitano, Daniela Barone, Sergio Di Meo, Paola Venditti
We studied the effects of adrenaline administration and depletion (induced by reserpine) on rat liver oxidative metabolism. We showed that adrenaline increases, and reserpine decreases aerobic capacity (inferred by cytochrome oxidase activity) in tissue modifying the hepatic content of mitochondrial proteins without changing mitochondrial aerobic capacity. The changes in tissue cytochrome oxidase activity, which agreed with the expression levels of factors involved in mitochondrial biogenesis, such as PGC-1, NRF-1, and NRF-2, were associated with similar changes in tissue and mitochondrial State 3 respiration...
December 14, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29209894/mitochondrial-energy-metabolism-and-signalling-in-human-glioblastoma-cell-lines-with-different-pten-gene-status
#2
Marina Comelli, Ivan Pretis, Alessia Buso, Irene Mavelli
Glioblastomas epidemiology and aggressiveness demand for a well characterization of biochemical mechanisms of the cells. The discovery of oxidative tumours related to chemoresistance is changing the prevalent view of dysfunctional mitochondria in cancer cells. Thus, glioblastomas metabolism is now an area of intense research, wherein was documented a high heterogeneity in energy metabolism and in particular in mitochondrial OxPhos. We report results gained by investigating mitochondrial OxPhos and bioenergetics, in a model of three human glioblastoma cell lines characterized by a different PTEN gene status...
December 6, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29204729/-nutrient-sensing-and-self-renewal-o-glcnac-in-a-new-role
#3
REVIEW
Nikita S Sharma, Ashok K Saluja, Sulagna Banerjee
Whether embryonic, hematopoietic or cancer stem cells, this metabolic reprogramming is dependent on the nutrient-status and bioenergetic pathways that is influenced by the micro-environmental niches like hypoxia. Thus, the microenvironment plays a vital role in determining the stem cell fate by inducing metabolic reprogramming. Under the influence of the microenvironment, like hypoxia, the stem cells have increased glucose and glutamine uptake which result in activation of hexosamine biosynthesis pathway (HBP) and increased O-GlcNAc Transferase (OGT)...
December 5, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29164469/antibiotic-anisomycin-induces-cell-cycle-arrest-and-apoptosis-through-inhibiting-mitochondrial-biogenesis-in-osteosarcoma
#4
Chuanhua Cao, Haiying Yu, Feng Wu, Huixiong Qi, Jingbo He
The anti-cancer activities of antibiotic anisomycin have been demonstrated in kidney, colon and ovarian cancers whereas its underlying mechanisms are not well elucidated. In this work, we investigated whether anisomycin is effective in sensitizes osteosarcoma cell response to chemotherapy. We show that anisomycin inhibits proliferation via inducing osteosarcoma cell arrest at G2/M phase, accompanied by the increased levels of mitotic marker cyclin B and the decreased levels of Rb and E2F-1. Anisomycin also induces apoptosis in a caspase-dependent manner in osteosarcoma cells...
November 21, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29147831/plants-of-brazilian-restingas-with-tripanocide-activity-against-trypanosoma-cruzi-strains
#5
Robson Xavier Faria, André Luis Almeida Souza, Barbara Lima, Luis Armando Candido Tietbohl, Caio Pinho Fernandes, Raquel Rodrigues Amaral, Bettina Monika Ruppelt, Marcelo Guerra Santos, Leandro Rocha
Chagas disease is caused by the Trypanosoma cruzi affecting millions of people, and widespread throughout Latin America. This disease exhibits a problematic chemotherapy. Benznidazole, which is the drug currently used as standard treatment, lamentably evokes several adverse reactions. Among other options, natural products have been tested to discover a novel therapeutic drug for this disease. A lot of plants from the Brazilian flora did not contain studies about their biological effects. Restinga de Jurubatiba from Brazil is a sandbank ecosystem poorly studied in relation to plant biological activity...
November 17, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29128917/heterologous-expression-of-mitochondrial-nicotinamide-adenine-dinucleotide-transporter-ndt1-from-aspergillus-fumigatus-rescues-impaired-growth-in-%C3%AE-ndt1%C3%AE-ndt2-saccharomyces-cerevisiae-strain
#6
Laís de Lourdes de Lima Balico, Emerson de Souza Santos, Silveli Suzuki-Hatano, Lucas Oliveira Sousa, Ana Elisa Caleiro Seixas Azzolini, Yara Maria Lucisano-Valim, Taisa Magnani Dinamarco, Vinicius Kannen, Sérgio Akira Uyemura
Our understanding of nicotinamide adenine dinucleotide mitochondrial transporter 1 (Ndt1A) in Aspergillus fumigatus remains poor. Thus, we investigated whether Ndt1A could alter fungi survival. To this end, we engineered the expression of an Ndt1A-encoding region in a Δndt1Δndt2 yeast strain. The resulting cloned Ndt1A protein promoted the mitochondrial uptake of nicotinamide adenine dinucleotide (NAD(+)), generating a large mitochondrial membrane potential. The NAD(+) carrier utilized the electrochemical proton gradient to drive NAD(+) entrance into mitochondria when the mitochondrial membrane potential was sustained by succinate...
November 11, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29127647/o-glcnacylation-in-women-s-cancers-breast-endometrial-and-ovarian
#7
REVIEW
Gloria M Trinca, Christy R Hagan
O-GlcNAcylation is emerging as a critical regulatory post-translational modification, impacting proteins that regulate cell division, apoptosis, metabolism, cell signaling, and transcription. O-GlcNAc also affects biological homeostasis by integrating information coming from the environment, such as nutrient conditions and extracellular stimuli, with cellular response. Aberrant O-GlcNAc modulation has been linked to metabolic and neurodegenerative diseases, as well as cancers. While many studies have highlighted the significance of O-GlcNAc in cancer, a specific function for O-GlcNAc during tumorigenesis remains unclear and seems to differ according to cancer type...
November 10, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29119364/correction-to-diffusion-coefficient-in-biomembrane-critical-pores
#8
Md Mozzammel Haque
The original version of this article unfortunately contained two mistakes.
November 8, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29047027/a-possible-mechanism-for-low-affinity-of-silkworm-na-k-atpase-for-k
#9
Haruo Homareda, Masahiro Otsu, Sachiko Yamamoto, Makoto Ushimaru, Sayaka Ito, Toshiyuki Fukutomi, Taeho Jo, Yoshinobu Eishi, Yukichi Hara
The affinity for K(+) of silkworm nerve Na(+)/K(+)-ATPase is markedly lower than that of mammalian Na(+)/K(+)-ATPase (Homareda 2010). In order to obtain clues on the molecular basis of the difference in K(+) affinities, we cloned cDNAs of silkworm (Bombyx mori) nerve Na(+)/K(+)-ATPase α and β subunits, and analyzed the deduced amino acid sequences. The molecular masses of the α and β subunits were presumed to be 111.5 kDa with ten transmembrane segments and 37.7 kDa with a single transmembrane segment, respectively...
October 19, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29043530/cox2a-cox2b-subunit-interaction-in-polytomella-sp-cytochrome-c-oxidase-role-of-the-cox2b-subunit-extension
#10
Alejandra Jiménez-Suárez, Miriam Vázquez-Acevedo, Héctor Miranda-Astudillo, Diego González-Halphen
Subunit II of cytochrome c oxidase (Cox2) is usually encoded in the mitochondrial genome, synthesized in the organelle, inserted co-translationally into the inner mitochondrial membrane, and assembled into the respiratory complex. In chlorophycean algae however, the cox2 gene was split into the cox2a and cox2b genes, and in some algal species like Chlamydomonas reinhardtii and Polytomella sp. both fragmented genes migrated to the nucleus. The corresponding Cox2A and Cox2B subunits are imported into mitochondria forming a heterodimeric Cox2 subunit...
October 17, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29018981/diffusion-coefficient-in-biomembrane-critical-pores
#11
Md Mozzammel Haque
Diffusion is fundamental to the random movement of solutes in solution throughout biological systems. Theoretical studies of diffusing solutes across cell membranes confined in a microscopic size of pores have been an interesting subject in life and medical sciences. When a solute is confined in a critical area of membrane pores, which shows a quite different behavior compared to the homogeneous-bulk fluid whose transport is isotropic in all directions. This property has novel features, which are of considerable physiological interest...
October 10, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28975445/from-autophagy-to-mitophagy-the-roles-of-p62-in-neurodegenerative-diseases
#12
REVIEW
Haiying Liu, Chunqiu Dai, Yunlong Fan, Baolin Guo, Keke Ren, Tangna Sun, Wenting Wang
P62, also called sequestosome1 (SQSTM1), is the selective cargo receptor for autophagy to degenerate misfolded proteins. It has also been found to assist and connect parkin in pink1/parkin mitophagy pathway. Previous studies showed that p62 was in association with neurodegenerative diseases, and one of the diseases pathogenesis is P62 induced autophagy and mitophagy dysfunction. Autophagy is an important process to eliminate misfolded proteins. Intracellular aggregation including α-synuclein, Huntingtin, tau protein and ß-amyloid (Aß) protein are the misfolded proteins found in PD, HD and AD, respectively...
October 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28900787/h-translocation-by-weak-acid-uncouplers-is-independent-of-h-electrochemical-gradient
#13
Jaromír Plášek, David Babuka, Milan Hoefer
According to the common view, weak acid uncouplers increase proton conductance of biological (and phospholipid bilayer) membranes, thus effecting H(+) fluxes driven by their electrochemical gradients. Under certain conditions, however, uncouplers can induce unexpected effects opposite to the dissipation of H(+) gradients. Results are presented here demonstrating CCCP-induced proton influx into Saccharomyces cerevisiae cytosol driven by the electrochemical potentials of CCCP and its CCCP(-) anions, independent of electrochemical H(+)-gradient...
October 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28852947/modeling-of-the-metabolic-energy-dissipation-for-restricted-tumor-growth
#14
Ivana Pajic-Lijakovic, Milan Milivojevic
Energy dissipation mostly represents unwanted outcome but in the biochemical processes it may alter the biochemical pathways. However, it is rarely considered in the literature although energy dissipation and its alteration due to the changes in cell microenvironment may improve methods for guiding chemical and biochemical processes in the desired directions. Deeper insight into the changes of metabolic activity of tumor cells exposed to osmotic stress or irradiation may offer the possibility of tumor growth reduction...
October 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28730272/mitochondria-as-a-target-of-cardioprotection-in-models-of-preconditioning
#15
REVIEW
Magdaléna Jašová, Ivana Kancirová, Iveta Waczulíková, Miroslav Ferko
Over the recent years the view on mitochondria in the heart as a cellular powerhouse providing ATP supply needed to sustain contractile function, basal metabolic processes, and ionic homeostasis has changed radically. At present it is known that dysfunctions of these organelles are essential in the development of a large number of diseases, including cardiovascular diseases. Moreover, mitochondria are considered to be a very promising target of endogenous strategies that are essential in the protection of the myocardium from acute ischemia/reperfusion injury...
October 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28695448/mitochondrial-atp-mg-phosphate-carriers-transport-divalent-inorganic-cations-in-complex-with-atp
#16
Magnus Monné, Lucia Daddabbo, Lorena Carla Giannossa, Maria Cristina Nicolardi, Luigi Palmieri, Daniela Valeria Miniero, Annarosa Mangone, Ferdinando Palmieri
The ATP-Mg/phosphate carriers (APCs) modulate the intramitochondrial adenine nucleotide pool size. In this study the concentration-dependent effects of Mg(2+) and other divalent cations (Me(2+)) on the transport of [(3)H]ATP in liposomes reconstituted with purified human and Arabidopsis APCs (hAPCs and AtAPCs, respectively, including some lacking their N-terminal domains) have been investigated. The transport of Me(2+) mediated by these proteins was also measured. In the presence of a low external concentration of [(3)H]ATP (12 μM) and increasing concentrations of Me(2+), Mg(2+) stimulated the activity (measured as initial transport rate of [(3)H]ATP) of hAPCs and decreased that of AtAPCs; Fe(2+) and Zn(2+) stimulated markedly hAPCs and moderately AtAPCs; Ca(2+) and Mn(2+) markedly AtAPCs and moderately hAPCs; and Cu(2+) decreased the activity of both hAPCs and AtAPCs...
October 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28643238/characterization-of-the-complex-involved-in-regulating-v-atpase-activity-of-the-vacuolar-and-endosomal-membrane
#17
REVIEW
Zhenyu Zhang, Xiaojiao Wang, Tangjie Gao, Chunyin Gu, Fubao Sun, Lin Yu, Jinguang Hu
Regulator of the H(+)-ATPase of the vacuolar and endosomal membranes (RAVE) is essential for the reversible assembly of H(+)-ATPase. RAVE primarily consists of three subunits: Rav1p, Rav2p and Skp1p. To characterize these subunits, in this study, four strains derived from Saccharomyces cerevisiae BY4742 were constructed with a FLAG tag on the Rav1p and Rav2p subunits. Then, the corresponding RAVE containing complex was isolated by affinity purification. Western blot and MALDI-TOF mass spectrometry analyses showed that the RAVE complex contains not only the known V1-ATPase subunits (Vma1p and Vma2p) but also a newly found Leu1p that interacts with the RAVE subunit...
October 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28918598/triacsin-c-reduces-lipid-droplet-formation-and-induces-mitochondrial-biogenesis-in-primary-rat-hepatocytes
#18
Carlos R P Dechandt, Felippe H Zuccolotto-Dos-Reis, Bruno G Teodoro, Anna Maria A P Fernandes, Marcos N Eberlin, Isis C Kettelhut, Carlos Curti, Luciane C Alberici
Intracellular long-chain acyl-CoA synthetases (ACSL) activate fatty acids to produce acyl-CoA, which undergoes β-oxidation and participates in the synthesis of esterified lipids such as triacylglycerol (TAG). Imbalances in these metabolic routes are closely associated with the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Triacsin C is one of the few compounds that inhibit TAG accumulation into lipid droplets (LD) by suppressing ACSL activity. Here we report that treatment of primary rat hepatocytes with triacsin C at concentrations lower than the IC50 (4...
September 16, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28799020/from-discovery-of-the-chop-axis-and-targeting-clpp-to-the-identification-of-additional-axes-of-the-uprmt-driven-by-the-estrogen-receptor-and-sirt3
#19
Timothy C Kenny, Doris Germain
The mitochondrial UPR (UPR(mt)) is rapidly gaining attention. While most studies on the UPR(mt) have focused on its role in aging, emerging studies suggest an important role of the UPR(mt) in cancer. Further, several of the players of the UPR(mt) in mammalian cells have well reported roles in the maintenance of the organelle. The goal of this review is to emphasize aspects of the UPR(mt) that have been overlooked in the current literature, describe the role of specific players of the UPR(mt) in the biology of the mitochondria and highlight the intriguing possibility that targeting the UPR(mt) in cancer may be already within reach...
August 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28639090/mitochondria-and-foxo3-in-stem-cell-homeostasis-a-window-into-hematopoietic-stem-cell-fate-determination
#20
Raymond Liang, Saghi Ghaffari
The production of all blood cells from hematopoietic stem cells (HSC) is highly sensitive to reactive oxygen species (ROS). Cumulating evidence suggests that mitochondria are critical for HSC fate determination. FOXO are known regulators of anti-oxidant response and key to the maintenance of HSC. Recent works indicate that FOXO3 is implicated in the control of mitochondrial function beyond regulating levels of ROS in HSC. Here we review these findings and discuss implications for homeostatic blood formation and stem cell fate determination...
August 2017: Journal of Bioenergetics and Biomembranes
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