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Journal of Bioenergetics and Biomembranes

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https://www.readbyqxmd.com/read/29790000/o-glcnac-cycling-in-the-developing-adult-and-geriatric-brain
#1
REVIEW
Olof Lagerlöf
Hundreds of proteins in the nervous system are modified by the monosaccharide O-GlcNAc. A single protein is often O-GlcNAcylated on several amino acids and the modification of a single site can play a crucial role for the function of the protein. Despite its complexity, only two enzymes add and remove O-GlcNAc from proteins, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Global and local regulation of these enzymes make it possible for O-GlcNAc to coordinate multiple cellular functions at the same time as regulating specific pathways independently from each other...
May 22, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29770896/mitochondrial-morphology-and-function-impaired-by-dimethyl-sulfoxide-and-dimethyl-formamide
#2
Long Ma, Jia-Xin Dong, Wen-Rong Fu, Xue-Yi Li, Jing Chen, Yi Liu
In this work, the effects of two non-ionic, non-hydroxyl organic solvents, dimethyl sulfoxide (DMSO) and dimethyl formamide (DMF) on the morphology and function of isolated rat hepatic mitochondria were investigated and compared. Mitochondrial ultrastructures impaired by DMSO and DMF were clearly observed by transmission electron microscopy. Spectroscopic and polarographic results demonstrated that organic solvents induced mitochondrial swelling, enhanced the permeation to H+ /K+ , collapsed the potential inner mitochondrial membrane (IMM), and increased the IMM fluidity...
May 17, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29721776/formation-of-lamellar-bodies-in-rat-liver-mitochondria-in-hyperthyroidism
#3
Natalya I Venediktova, Lubov L Pavlik, Natalia V Belosludtseva, Natalya V Khmil, Svetlana V Murzaeva, Galina D Mironova
In the present work, ultrastructural changes of rat liver mitochondria in hyperthyroidism were studied. Hyperthyroidism was induced in male Wistar rats by daily administration of 100 μg thyroxin per 100 g body weight for 5 days. The level of triiodothyronine and thyroxine increased 3- and 4-fold, respectively, in comparison with the same parameters in the control group, indicating the development of hyperthyroidism in experimental animals. It was found that under this experimental pathology 58% of the mitochondria are swollen, with their matrix enlightened, as compared to the control...
May 3, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29687367/atovaquone-enhances-doxorubicin-s-efficacy-via-inhibiting-mitochondrial-respiration-and-stat3-in-aggressive-thyroid-cancer
#4
Zhuo Lv, Xintong Yan, Liying Lu, Chun Su, Yin He
The clinical management of anaplastic thyroid carcinoma and follicular thyroid carcinoma is challenging and requires an alternative therapeutic strategy. Although atovaquone is an FDA-approved anti-malarial drug, studies has recently demonstrated its anti-cancer activities. In line with these efforts, our study shows that atovaquone is an attractive candidate for thyroid cancer treatment. We show that atovaquone significantly inhibits growth, migration and survival in a concentration-dependent manner in 8505C and FTC113 cells...
April 23, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29687366/molecular-modeling-of-non-covalent-binding-of-ligustrum-lucidum-secoiridoid-glucosides-to-ap-1-matrix-metalloproteinase-pathway-components
#5
Pathomwat Wongrattanakamon, Piyarat Nimmanpipug, Busaban Sirithunyalug, Wantida Chaiyana, Supat Jiranusornkul
Ligustrum lucidum secoiridoid glucosides have been demonstrated to treat various types of diseases such as inflammation, pain, hepatotoxicity and hyperlipidermic as well as tonic for liver and kidney. Matrix metalloproteinases (MMPs) play a key role upon the pathology of photoaging. The present computational study showed that among the six secoiridoid glucosides (ligustroside, lucidumoside A, lucidumoside C, neonuezhenide, oleoside dimethylester, and oleuropein), ligustroside and lucidumoside A competitively inhibit all MMP-1, MMP-3, and MMP-9 activities in the docking models...
April 23, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29675736/decreased-content-rate-of-synthesis-and-export-of-cholesterol-in-the-brain-of-apoe-knockout-mice
#6
Valéria Sutti Nunes, Patrícia Miralda Cazita, Sérgio Catanozi, Edna Regina Nakandakare, Eder Carlos Rocha Quintão
Apolipoprotein E knockout (apoE-KO) mice present synaptic loss, cognitive dysfunction, and high plasma lipid levels that may affect brain function simulating Alzheimer disease. Plasma and brain sterols were measured in apoE-KO and in wild type control mice on a cholesterol-free, phytosterol-containing diet by gas chromatography coupled to a mass spectrometer. Plasma cholesterol and phytosterols (campesterol and sitosterol) were higher in apoE-KO compared to control mice. Cholesterol precursors (desmosterol and lathosterol) were not detected in plasma of control mice but were present in apoE-KO mice...
April 20, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29671171/new-use-for-cetsa-monitoring-innate-immune-receptor-stability-via-post-translational-modification-by-ogt
#7
Walter R Drake, Ching-Wen Hou, Natasha E Zachara, Catherine Leimkuhler Grimes
O-GlcNAcylation is a dynamic and functionally diverse post-translational modification shown to affect thousands of proteins, including the innate immune receptor nucleotide-binding oligomerization domain-containing protein 2 (Nod2). Mutations of Nod2 (R702W, G908R and 1007 fs) are associated with Crohn's disease and have lower stabilities compared to wild type. Cycloheximide (CHX)-chase half-life assays have been used to show that O-GlcNAcylation increases the stability and response of both wild type and Crohn's variant Nod2, R702W...
April 18, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29594839/o-glcnac-in-cancer-an-oncometabolism-fueled-vicious-cycle
#8
REVIEW
John A Hanover, Weiping Chen, Michelle R Bond
Cancer cells exhibit unregulated growth, altered metabolism, enhanced metastatic potential and altered cell surface glycans. Fueled by oncometabolism and elevated uptake of glucose and glutamine, the hexosamine biosynthetic pathway (HBP) sustains glycosylation in the endomembrane system. In addition, the elevated pools of UDP-GlcNAc drives the O-GlcNAc modification of key targets in the cytoplasm, nucleus and mitochondrion. These targets include transcription factors, kinases, key cytoplasmic enzymes of intermediary metabolism, and electron transport chain complexes...
March 29, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29594796/alternative-mitochondrial-respiratory-chains-from-two-crustaceans-artemia-franciscana-nauplii-and-the-white-shrimp-litopenaeus-vannamei
#9
Chrystian Rodriguez-Armenta, Salvador Uribe-Carvajal, Monica Rosas-Lemus, Natalia Chiquete-Felix, Jose Angel Huerta-Ocampo, Adriana Muhlia-Almazan
Mitochondrial ATP is synthesized by coupling between the electron transport chain and complex V. In contrast, physiological uncoupling of these processes allows mitochondria to consume oxygen at high rates without ATP synthesis. Such uncoupling mechanisms prevent reactive oxygen species overproduction. One of these mechanisms are the alternative redox enzymes from the mitochondrial respiratory chain, which may help cells to maintain homeostasis under stress independently of ATP synthesis. To date, no reports have been published on alternative redox enzymes in crustaceans mitochondria...
March 29, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29589262/ocimum-basilicum-but-not-ocimum-gratissimum-present-cytotoxic-effects-on-human-breast-cancer-cell-line-mcf-7-inducing-apoptosis-and-triggering-mtor-akt-p70s6k-pathway
#10
Renan Gianoti Torres, Livia Casanova, Julia Carvalho, Mariah Celestino Marcondes, Sonia Soares Costa, Mauro Sola-Penna, Patricia Zancan
Breast cancer is the major cause of death by cancer in women worldwide and in spite of the many drugs for its treatment, there is still the need for novel therapies for its control. Ocimum species have been used by traditional medicine to control several diseases, including cancer. We have previously characterized the antidiabetic properties of the unfractionated aqueous leaf extracts of Ocimum basilicum (OB) and Ocimum gratissimum (OG), modulating glucose metabolism in diabetic mice. Since glucose metabolism is primordial for cancer cells survival, we hypothesized that these extracts are effective against cancer cells...
March 28, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29589261/skeletal-muscle-overexpression-of-short-isoform-sirt3-altered-mitochondrial-cardiolipin-content-and-fatty-acid-composition
#11
Béatrice Chabi, Gilles Fouret, Jérome Lecomte, Fabienne Cortade, Laurence Pessemesse, Narjès Baati, Charles Coudray, Ligen Lin, Qiang Tong, Chantal Wrutniak-Cabello, François Casas, Christine Feillet-Coudray
Cardiolipin (CL) is a phospholipid at the heart of mitochondrial metabolism, which plays a key role in mitochondrial function and bioenergetics. Among mitochondrial activity regulators, SIRT3 plays a crucial role in controlling the acetylation status of many enzymes participating in the energy metabolism in particular concerning lipid metabolism and fatty acid oxidation. Data suggest that possible connection may exist between SIRT3 and CL status that has not been evaluated in skeletal muscle. In the present study, we have characterized skeletal muscle lipids as well as mitochondrial lipids composition in mice overexpressing long (SIRT3-M1) and short (SIRT3-M3) isoforms of SIRT3...
March 27, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29524020/cross-regulation-between-mtor-signaling-and-o-glcnacylation
#12
Ninon Very, Agata Steenackers, Caroline Dubuquoy, Jeanne Vermuse, Laurent Dubuquoy, Tony Lefebvre, Ikram El Yazidi-Belkoura
The hexosamine biosynthetic pathway (HBP) integrates glucose, amino acids, fatty acids and nucleotides metabolisms for uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) synthesis. UDP-GlcNAc is the nucleotide sugar donor for O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) processes. O-GlcNAc transferase (OGT) is the enzyme which transfers the N-acetylglucosamine (O-GlcNAc) residue onto target proteins. Several studies previously showed that glucose metabolism dysregulations associated with obesity, diabetes or cancer correlated with an increase of OGT expression and global O-GlcNAcylation levels...
March 9, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29524019/aberrant-gsh-reductase-and-nox-activities-concur-with-defective-cftr-to-pro-oxidative-imbalance-in-cystic-fibrosis-airways
#13
L de Bari, M Favia, A Bobba, R Lassandro, L Guerra, A Atlante
Cystic fibrosis (CF) is associated to impaired Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel also causing decreased glutathione (GSH) secretion, defective airway bacterial clearance and inflammation. Here we checked the main ROS-producing and ROS-scavenging enzymes as potential additional factors involved in CF pathogenesis. We found that CFBE41o-cells, expressing F508del CFTR, have increased NADPH oxidase (NOX) activity and expression level, mainly responsible of the increased ROS production, and decreased glutathione reductase (GR) activity, not dependent on GR protein level decrease...
April 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29520697/the-cytotoxic-apoptotic-and-oxidative-effects-of-carbonic-anhydrase-ix-inhibitor-on-colorectal-cancer-cells
#14
Yasin Tülüce, Bewar Ali Ahmed, İsmail Koyuncu, Mustafa Durgun
Colorectal cancer (CRC) is the third most common tumor, malignant and has developed one of the main reasons of cancer mortality. According to studies conducted recently; carbonic anhydrase 9 (CAIX) is an especially attractive target for cancer therapy, in part since it is limited way expressed in normal tissues on the other hand in a wide variety of solid neoplasia are overexpressed. The aim of this study was to appreciate the effects of CAIX inhibitor, namely novel synthesized sulfonamide derivative (H-4i) with high affinity for CAIX, in CAIX-positive human colorectal cancer cell (HT-29) and CAIX-negative human normal embryonic kidney cell line (HEK-293)...
April 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29473131/searching-for-new-drugs-for-chagas-diseases-triazole-analogs-display-high-in-vitro-activity-against-trypanosoma-cruzi-and-low-toxicity-toward-mammalian-cells
#15
Robson Xavier Faria, Daniel Tadeu Gomes Gonzaga, Paulo Anastácio Furtado Pacheco, André Luis Almeida Souza, Vitor Francisco Ferreira, Fernando de Carvalho da Silva
Chagas disease is one of the most relevant endemic diseases in Latin America caused by the flagellate protozoan Trypanosoma cruzi. Nifurtimox and benzonidazole are the drugs used in the treatment of this disease, but they commonly are toxic and present severe side effects. New effective molecules, without collateral effects, has promoted the investigation to develop new lead compounds with to advance for clinical trials. Previously, 3-nitro-1H-1,2,4-triazole-based amines and 1,2,3-triazoles demonstrated significant trypanocidal activity against T...
April 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29404877/o-glcnac-a-novel-regulator-of-immunometabolism
#16
REVIEW
Miranda Machacek, Chad Slawson, Patrick E Fields
The rapidly expanding field of immunometabolism focuses on how metabolism controls the function of immune cells. CD4+ T cells are essential for the adaptive immune response leading to the eradication of specific pathogens. However, when T cells are inappropriately over-active, they can drive autoimmunity, allergic disease, and chronic inflammation. The mechanisms by which metabolic changes influence function in CD4+ T cells are not fully understood. The post-translational protein modification, O-GlcNAc (O-linked β-N-acetylglucosamine), dynamically cycles on and off of intracellular proteins as cells respond to their environment and flux through metabolic pathways changes...
February 6, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29426977/investigation-of-the-phosphatidylserine-binding-properties-of-the-lipid-biosensor-lactadherin-c2-lactc2-in-different-membrane-environments
#17
Kathryn Del Vecchio, Robert V Stahelin
Lipid biosensors are robust tools used in both in vitro and in vivo applications of lipid imaging and lipid detection. Lactadherin C2 (LactC2) was described in 2000 as being a potent and specific sensor for phosphatidylserine (PS) (Andersen et al. Biochemistry 39:6200-6206, 2000). PS is an anionic phospholipid enriched in the inner leaflet of the plasma membrane and has paramount roles in apoptosis, cells signaling, and autophagy. The myriad roles PS plays in membrane dynamics make monitoring PS levels and function an important endeavor...
February 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29332207/skeletal-muscle-expression-of-p43-a-truncated-thyroid-hormone-receptor-%C3%AE-affects-lipid-composition-and-metabolism
#18
François Casas, Gilles Fouret, Jérome Lecomte, Fabienne Cortade, Laurence Pessemesse, Emilie Blanchet, Chantal Wrutniak-Cabello, Charles Coudray, Christine Feillet-Coudray
Thyroid hormone is a major regulator of metabolism and mitochondrial function. Thyroid hormone also affects reactions in almost all pathways of lipids metabolism and as such is considered as the main hormonal regulator of lipid biogenesis. The aim of this study was to explore the possible involvement of p43, a 43 Kda truncated form of the nuclear thyroid hormone receptor TRα1 which stimulates mitochondrial activity. Therefore, using mouse models overexpressing p43 in skeletal muscle (p43-Tg) or lacking p43 (p43-/-), we have investigated the lipid composition in quadriceps muscle and in mitochondria...
February 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29313294/chlorpromazine-and-dimethyl-sulfoxide-modulate-the-catalytic-activity-of-the-plasma-membrane-ca-2-atpase-from-human-erythrocyte
#19
Fernando Plenge-Tellechea, Carlos A Domínguez-Solís, Ángel G Díaz-Sánchez, David Meléndez-Martínez, Javier Vargas-Medrano, Jorge A Sierra-Fonseca
The plasma membrane Ca2+ -ATPase (PMCA) removes Ca2+ from the cytosol into the extracellular space. Its catalytic activity can be stimulated by calmodulin (CaM) or by limited proteolysis. We evaluated the effect of chlorpromazine (CPZ) and dimethyl sulfoxide (DMSO) over the hydrolytic activity of PMCA. Activity was monitored in three different forms: native, CaM-activated and proteolyzed by trypsin. CPZ appears to inhibit PMCA without directly interfering with the C-terminal site, since it is affected by CaM and proteolysis...
February 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29302769/imidacloprid-impedes-mitochondrial-function-and-induces-oxidative-stress-in-cotton-bollworm-helicoverpa-armigera-larvae-hubner-noctuidae
#20
Bharat Nareshkumar, Shaik Mohammad Akbar, Hari Chand Sharma, Senigala K Jayalakshmi, Kuruba Sreeramulu
Neonicotinoids have high agonistic affinity to insect nicotinic acetylcholine receptors (nAChR) and are frequently used as insecticides against most devastating lepidopteran insect pests. Imidacloprid influenced dose-dependent decline in the state III and IV respiration, respiration control index (RCI), and P/O ratios, in vitro and in vivo. The bioassay indicated its LD50 value to be 531.24 μM. The insecticide exhibited a dose-dependent inhibition on F0 F1 -ATPase and complex IV activity. At 600 μM, the insecticide inhibited 83...
February 2018: Journal of Bioenergetics and Biomembranes
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