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Journal of Bioenergetics and Biomembranes

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https://www.readbyqxmd.com/read/28799020/from-discovery-of-the-chop-axis-and-targeting-clpp-to-the-identification-of-additional-axes-of-the-uprmt-driven-by-the-estrogen-receptor-and-sirt3
#1
Timothy C Kenny, Doris Germain
The mitochondrial UPR (UPR(mt)) is rapidly gaining attention. While most studies on the UPR(mt) have focused on its role in aging, emerging studies suggest an important role of the UPR(mt) in cancer. Further, several of the players of the UPR(mt) in mammalian cells have well reported roles in the maintenance of the organelle. The goal of this review is to emphasize aspects of the UPR(mt) that have been overlooked in the current literature, describe the role of specific players of the UPR(mt) in the biology of the mitochondria and highlight the intriguing possibility that targeting the UPR(mt) in cancer may be already within reach...
August 10, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28730272/mitochondria-as-a-target-of-cardioprotection-in-models-of-preconditioning
#2
REVIEW
Magdaléna Jašová, Ivana Kancirová, Iveta Waczulíková, Miroslav Ferko
Over the recent years the view on mitochondria in the heart as a cellular powerhouse providing ATP supply needed to sustain contractile function, basal metabolic processes, and ionic homeostasis has changed radically. At present it is known that dysfunctions of these organelles are essential in the development of a large number of diseases, including cardiovascular diseases. Moreover, mitochondria are considered to be a very promising target of endogenous strategies that are essential in the protection of the myocardium from acute ischemia/reperfusion injury...
July 20, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28695448/mitochondrial-atp-mg-phosphate-carriers-transport-divalent-inorganic-cations-in-complex-with-atp
#3
Magnus Monné, Lucia Daddabbo, Lorena Carla Giannossa, Maria Cristina Nicolardi, Luigi Palmieri, Daniela Valeria Miniero, Annarosa Mangone, Ferdinando Palmieri
The ATP-Mg/phosphate carriers (APCs) modulate the intramitochondrial adenine nucleotide pool size. In this study the concentration-dependent effects of Mg(2+) and other divalent cations (Me(2+)) on the transport of [(3)H]ATP in liposomes reconstituted with purified human and Arabidopsis APCs (hAPCs and AtAPCs, respectively, including some lacking their N-terminal domains) have been investigated. The transport of Me(2+) mediated by these proteins was also measured. In the presence of a low external concentration of [(3)H]ATP (12 μM) and increasing concentrations of Me(2+), Mg(2+) stimulated the activity (measured as initial transport rate of [(3)H]ATP) of hAPCs and decreased that of AtAPCs; Fe(2+) and Zn(2+) stimulated markedly hAPCs and moderately AtAPCs; Ca(2+) and Mn(2+) markedly AtAPCs and moderately hAPCs; and Cu(2+) decreased the activity of both hAPCs and AtAPCs...
July 10, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28643238/characterization-of-the-complex-involved-in-regulating-v-atpase-activity-of-the-vacuolar-and-endosomal-membrane
#4
REVIEW
Zhenyu Zhang, Xiaojiao Wang, Tangjie Gao, Chunyin Gu, Fubao Sun, Lin Yu, Jinguang Hu
Regulator of the H(+)-ATPase of the vacuolar and endosomal membranes (RAVE) is essential for the reversible assembly of H(+)-ATPase. RAVE primarily consists of three subunits: Rav1p, Rav2p and Skp1p. To characterize these subunits, in this study, four strains derived from Saccharomyces cerevisiae BY4742 were constructed with a FLAG tag on the Rav1p and Rav2p subunits. Then, the corresponding RAVE containing complex was isolated by affinity purification. Western blot and MALDI-TOF mass spectrometry analyses showed that the RAVE complex contains not only the known V1-ATPase subunits (Vma1p and Vma2p) but also a newly found Leu1p that interacts with the RAVE subunit...
June 22, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28639090/mitochondria-and-foxo3-in-stem-cell-homeostasis-a-window-into-hematopoietic-stem-cell-fate-determination
#5
Raymond Liang, Saghi Ghaffari
The production of all blood cells from hematopoietic stem cells (HSC) is highly sensitive to reactive oxygen species (ROS). Cumulating evidence suggests that mitochondria are critical for HSC fate determination. FOXO are known regulators of anti-oxidant response and key to the maintenance of HSC. Recent works indicate that FOXO3 is implicated in the control of mitochondrial function beyond regulating levels of ROS in HSC. Here we review these findings and discuss implications for homeostatic blood formation and stem cell fate determination...
June 21, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28616679/manganese-superoxide-dismutase-sod2-is-there-a-center-in-the-universe-of-mitochondrial-redox-signaling
#6
REVIEW
Xianghui Zou, Bianca A Ratti, Joseph Gerald O'Brien, Sueli O Lautenschlager, David R Gius, Marcelo G Bonini, Yueming Zhu
It is becoming increasingly clear that mitochondria drive cellular functions and in vivo phenotypes by directing the production rate and abundance of metabolites that are proposed to function as signaling molecules (Chandel 2015; Selak et al. 2005; Etchegaray and Mostoslavsky 2016). Many of these metabolites are intermediates that make up cellular metabolism, part of which occur in mitochondria (i.e. the TCA and urea cycles), while others are produced "on demand" mainly in response to alterations in the microenvironment in order to participate in the activation of acute adaptive responses (Mills et al...
June 14, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28573491/p2x7-receptor-large-pore-signaling-in-avian-m%C3%A3-ller-glial-cells
#7
Robson X Faria, Hercules R Freitas, Ricardo A M Reis
ATP is a pleiotropic molecule that promotes extra- and intracellular signaling to regulate numerous functions. This nucleotide activates purine and pyrimidine receptors at the plasma membrane, categorized as ionotropic P2X or G-protein-coupled receptor (GPCR) P2Y receptors. P2X are ligand-gated ion channel receptors, expressed in both retinal neurons and Müller cells leading to neuron-glia communication, calcium waves and neurovascular coupling. However, how P2X pore is formed upon ATP activation and how signaling pathways regulates the complex is still a matter of controversy...
June 1, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28555290/toward-the-identification-and-the-targeting-of-key-players-of-the-mitochondrial-unfolded-protein-response-upr-mt-in-cancer
#8
Doris Germain
No abstract text is available yet for this article.
May 29, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28547157/shikonin-induces-necroptosis-by-reactive-oxygen-species-activation-in-nasopharyngeal-carcinoma-cell-line-cne-2z
#9
Zixuan Zhang, Zhirui Zhang, Qixiang Li, Hao Jiao, Dianlong Chong, Xiaojin Sun, Pei Zhang, Qiang Huo, Hao Liu
Shikonin, a natural small agent, has shown inhibitory effect in many kinds of cells, which increases intracellular reactive oxygen species (ROS) level and causes mitochondrial injury. In this study, shikonin showed good inhibitory effect on nasopharyngeal carcinoma CNE-2Z cells in vivo and vitro. The results presented here revealed that ROS levels increased markly after shikonin treated. The electron microscopy displays the change in ultrastructure of CNE-2Z cells after treatment for shikonin, which indicated that shikonin induced necroptosis...
May 25, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28478591/glutamate-contributes-to-alcohol-hepatotoxicity-by-enhancing-oxidative-stress-in-mitochondria
#10
Vera V Teplova, Alexey G Kruglov, Leonid I Kovalyov, Anna B Nikiforova, Nadezhda I Fedotcheva, John J Lemasters
Chronic alcohol intoxication is associated with increased oxidative stress. However, the mechanisms by which ethanol triggers an increase in the production of reactive oxygen species (ROS) and the role of mitochondria in the development of oxidative stress has been insufficiently studied. The biochemical and proteomic data obtained in the present work suggest that one of the main causes of an increase in ROS generation is enhanced oxidation of glutamate in response to long-term alcohol exposure. In the course of glutamate oxidation, liver mitochondria from alcoholic rats generated more superoxide anion and H2O2 than in the presence of other substrates and more than control organelles...
June 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28528361/toward-the-identification-and-the-targeting-of-key-players-of-the-mitochondrial-unfolded-protein-response-upr-mt-in-cancer
#11
EDITORIAL
Doris Germain
No abstract text is available yet for this article.
May 20, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28429159/a-brief-history-of-the-discovery-of-the-mitochondrial-unfolded-protein-response-in-mammalian-cells
#12
Nick Hoogenraad
Cells have responded to stresses which cause proteins to come out of solution by evolving unfolded protein response mechanisms. In eukaryotic cells there are several such mechanisms covering the whole cell and sub-celllular organelles. This review describes discoveries that describe the unfolded protein response in the matrix compartment of mitochondria (mtUPRR) of mammalian cells.
April 20, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28417222/role-of-foxo-transcription-factors-in-crosstalk-between-mitochondria-and-the-nucleus
#13
Sujin Kim, Hyongjong Koh
FOXO transcription factors are evolutionally conserved regulators of organismal life span downstream of insulin signaling. After integrating cellular signals from various stimuli such as growth factors, oxidative stress, and energy deprivation, FOXO factors induce expression of a specific set of genes that regulate various cellular processes to maintain homeostasis at a cellular or organismal level. In this review, we discuss roles of FOXO proteins in the maintenance of mitochondria, organelles critical for cellular quality control...
April 17, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28405872/a-novel-method-for-assessment-of-local-ph-in-periplasmic-space-and-of-cell-surface-potential-in-yeast
#14
Jaromír Plášek, David Babuka, Dana Gášková, Iva Jančíková, Jakub Zahumenský, Milan Hoefer
Yeast cells exhibit a negative surface potential due to negative charges at the cell membrane surface. Consequently, local concentrations of cations at the periplasmic membrane surface may be significantly increased compared to their bulk environment. However, in cell suspensions only bulk concentrations of cations can be measured directly. Here we present a novel method enabling the assessment of local pH at the periplasmic membrane surface which can be directly related to the underlying cell surface potential...
April 12, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28401438/resveratrol-induces-mitochondrial-dysfunction-and-decreases-chronological-life-span-of-saccharomyces-cerevisiae-in-a-glucose-dependent-manner
#15
Minerva Ramos-Gomez, Ivanna Karina Olivares-Marin, Melina Canizal-García, Juan Carlos González-Hernández, Gerardo M Nava, Luis Alberto Madrigal-Perez
A broad range of health benefits have been attributed to resveratrol (RSV) supplementation in mammalian systems, including the increases in longevity. Nonetheless, despite the growing number of studies performed with RSV, the molecular mechanism by which it acts still remains unknown. Recently, it has been proposed that inhibition of the oxidative phosphorylation activity is the principal mechanism of RSV action. This mechanism suggests that RSV might induce mitochondrial dysfunction resulting in oxidative damage to cells with a concomitant decrease of cell viability and cellular life span...
April 11, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28401437/estrogens-regulate-life-and-death-in-mitochondria
#16
Carolyn M Klinge
Estrogens coordinate and integrate cellular metabolism and mitochondrial activities by direct and indirect mechanisms mediated by differential expression and localization of estrogen receptors (ER) in a cell-specific manner. Estrogens regulate transcription and cell signaling pathways that converge to stimulate mitochondrial function- including mitochondrial bioenergetics, mitochondrial fusion and fission, calcium homeostasis, and antioxidant defense against free radicals. Estrogens regulate nuclear gene transcription by binding and activating the classical genomic estrogen receptors α and β (ERα and ERβ) and by activating plasma membrane-associated mERα, mERβ, and G-protein coupled ER (GPER, GPER1)...
April 11, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28078625/analysis-of-an-n-terminal-deletion-in-subunit-a-of-the-escherichia-coli-atp-synthase
#17
Robert R Ishmukhametov, Jessica DeLeon-Rangel, Shaotong Zhu, Steven B Vik
Subunit a is a membrane-bound stator subunit of the ATP synthase and is essential for proton translocation. The N-terminus of subunit a in E. coli is localized to the periplasm, and contains a sequence motif that is conserved among some bacteria. Previous work has identified mutations in this region that impair enzyme activity. Here, an internal deletion was constructed in subunit a in which residues 6-20 were replaced by a single lysine residue, and this mutant was unable to grow on succinate minimal medium...
April 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28364383/acridine-yellow-a-novel-use-to-estimate-and-measure-the-plasma-membrane-potential-in-saccharomyces-cerevisiae
#18
Martha Calahorra, Norma Silvia Sánchez, Antonio Peña
Translocation of ions and other molecules across the plasma membrane of yeast requires the electric potential generated by a H(+)-ATPase. We measured under different conditions fluorescence changes and accumulation of acridine yellow, looking for qualitative and quantitative estimations of the PMP in Saccharomyces cerevisiae in various conditions. Fluorescence changes indicated an accumulation of the dye requiring a substrate, and accumulation and quenching by mitochondria that could be released by an uncoupler...
March 31, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28337566/liver-mitochondrial-membrane-fluidity-at-early-development-of-diabetes-and-its-correlation-with-the-respiration
#19
Ismael H Pérez-Hernández, Josué Misael Domínguez-Fuentes, Martín Palomar-Morales, Ana Cecilia Zazueta-Mendizabal, Arturo Baiza-Gutman, Ricardo Mejía-Zepeda
The biological membranes are important in cell function but, during development of diseases such as diabetes, they are impaired. Consequently, membrane-associated biological processes are impaired as well. The mitochondria are important organelles where oxidative phosphorylation takes place, a process closely related with the membranes. In general, it is accepted that the development process of diabetes decreases membrane fluidity. However, in some cases, it has been found to increase membrane fluidity of mitochondria but to decrease the Respiratory Control (RC) index...
March 24, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28275929/in-silico-and-in-vitro-investigation-on-the-phenylalanine-metabolites-interactions-with-hexokinase-of-rat-s-brain-mitochondria
#20
Nasrin Ziamajidi, Shirin Jamshidi, Abdolvahab Ehsani-Zonouz
Hexokinase (HK) is the first enzyme of glycolysis pathway. In brain, most dominant form of HK, HK-I, binds reversibly to the outer mitochondria membrane. Those metabolites that affect binding or releasing of the enzyme from the mitochondria have regulatory effect on glucose consumption of the cell. In this study destructive effect of phenylalanine and its metabolites in relation to glucose metabolism in brain have been studied. The results show that phenylpyruvic acid decreases the activity of enzyme in the presence and absence of glucose-6-phosphate (G6P) and increases the release of the enzyme from mitochondria, whereas phenylalanine and phenyllactic acid have no such effects...
March 8, 2017: Journal of Bioenergetics and Biomembranes
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