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Journal of Bioenergetics and Biomembranes

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https://www.readbyqxmd.com/read/29998379/the-complexity-of-mitochondrial-outer-membrane-permeability-and-vdac-regulation-by-associated-proteins
#1
Aleksandr Klepinin, Lyudmila Ounpuu, Kati Mado, Laura Truu, Vladimir Chekulayev, Marju Puurand, Igor Shevchuk, Kersti Tepp, Anu Planken, Tuuli Kaambre
Previous studies have shown that class II β-tubulin plays a key role in the regulation of oxidative phosphorylation (OXPHOS) in some highly differentiated cells, but its role in malignant cells has remained unclear. To clarify these aspects, we compared the bioenergetic properties of HL-1 murine sarcoma cells, murine neuroblastoma cells (uN2a) and retinoic acid - differentiated N2a cells (dN2a). We examined the expression and possible co-localization of mitochondrial voltage dependent anion channel (VDAC) with hexokinase-2 (HK-2) and βII-tubulin, the role of depolymerized βII-tubuline and the effect of both proteins in the regulation of mitochondrial outer membrane (MOM) permeability...
July 12, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29943164/different-mitochondrial-response-to-cisplatin-and-hyperthermia-treatment-in-human-ags-caco-2-and-t3m4-cancer-cell-lines
#2
Sonata Trumbeckaite, Vaidotas Cesna, Aldona Jasukaitiene, Rasa Baniene, Antanas Gulbinas
Gastrointestinal cancers (gastric, pancreatic and colorectal) are life-threatening diseases, which easily spread to peritoneal cavity (Juhl et al. in Int J Cancer 57:330-335, 1994; Schneider et al. in Gastroenterology 128:1606-1625, 2005; Geer and Brennan in Am J Surg 165:68-72 1993). Application of hyperthermal intraperitoneal chemotherapy (HIPEC) is one of the choices treating these malignancies and prolonging patient survival time. Despite numbers of clinical trials showing positive effects of HIPEC against various types of cancer, the question whether hyperthermia significantly potentiate the cytotoxicity of cisplatin remains unanswered...
June 25, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29882206/purinergic-receptors-and-neglected-tropical-diseases-why-ignore-purinergic-signaling-in-the-search-for-new-molecular-targets
#3
REVIEW
P A F Pacheco, L P Dantas, L G B Ferreira, Robson Xavier Faria
Purinergic receptors are widespread in the human organism and are involved in several physiological functions like neurotransmission, nociception, platelet aggregation, etc. In the immune system, they may regulate the expression and release of pro-inflammatory factors as well as the activation and death of several cell types. It is already described the participation of some purinergic receptors in the inflammation and pathological processes, such as a few neglected tropical diseases (NTDs) which affect more than 1 billion people in the world...
June 7, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29882205/downregulation-of-monocarboxylate-transporter-1-inhibits-the-invasion-and-migration-through-suppression-of-the-pi3k-akt-signaling-pathway-in-human-nasopharyngeal-carcinoma-cells
#4
Pei Zhang, Jie Ma, Jiao Gao, Fang Liu, Xiaojin Sun, Fang Fang, Surong Zhao, Hao Liu
Monocarboxylate transporter 1 (MCT1) has been reported to be correlated wtih decreased survival and advanced stage of progression in a series of human tumor cells and primary cancers. Specifically, MCT1 has been documented to be involved in tumor progression, including invasion and migration. Here, we investigated the mechanism and effect of regulation of MCT1 on invasion and migration of nasopharyngeal carcinoma (NPC) cells. In the study, we firstly demonstrated that the expression of MCT1 in CNE2Z cells was obviously higher than that in HNE1 cells...
June 7, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29770896/mitochondrial-morphology-and-function-impaired-by-dimethyl-sulfoxide-and-dimethyl-formamide
#5
Long Ma, Jia-Xin Dong, Wen-Rong Fu, Xue-Yi Li, Jing Chen, Yi Liu
In this work, the effects of two non-ionic, non-hydroxyl organic solvents, dimethyl sulfoxide (DMSO) and dimethyl formamide (DMF) on the morphology and function of isolated rat hepatic mitochondria were investigated and compared. Mitochondrial ultrastructures impaired by DMSO and DMF were clearly observed by transmission electron microscopy. Spectroscopic and polarographic results demonstrated that organic solvents induced mitochondrial swelling, enhanced the permeation to H+ /K+ , collapsed the potential inner mitochondrial membrane (IMM), and increased the IMM fluidity...
May 17, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29721776/formation-of-lamellar-bodies-in-rat-liver-mitochondria-in-hyperthyroidism
#6
Natalya I Venediktova, Lubov L Pavlik, Natalia V Belosludtseva, Natalya V Khmil, Svetlana V Murzaeva, Galina D Mironova
In the present work, ultrastructural changes of rat liver mitochondria in hyperthyroidism were studied. Hyperthyroidism was induced in male Wistar rats by daily administration of 100 μg thyroxin per 100 g body weight for 5 days. The level of triiodothyronine and thyroxine increased 3- and 4-fold, respectively, in comparison with the same parameters in the control group, indicating the development of hyperthyroidism in experimental animals. It was found that under this experimental pathology 58% of the mitochondria are swollen, with their matrix enlightened, as compared to the control...
August 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29687367/atovaquone-enhances-doxorubicin-s-efficacy-via-inhibiting-mitochondrial-respiration-and-stat3-in-aggressive-thyroid-cancer
#7
Zhuo Lv, Xintong Yan, Liying Lu, Chun Su, Yin He
The clinical management of anaplastic thyroid carcinoma and follicular thyroid carcinoma is challenging and requires an alternative therapeutic strategy. Although atovaquone is an FDA-approved anti-malarial drug, studies has recently demonstrated its anti-cancer activities. In line with these efforts, our study shows that atovaquone is an attractive candidate for thyroid cancer treatment. We show that atovaquone significantly inhibits growth, migration and survival in a concentration-dependent manner in 8505C and FTC113 cells...
August 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29687366/molecular-modeling-of-non-covalent-binding-of-ligustrum-lucidum-secoiridoid-glucosides-to-ap-1-matrix-metalloproteinase-pathway-components
#8
Pathomwat Wongrattanakamon, Piyarat Nimmanpipug, Busaban Sirithunyalug, Wantida Chaiyana, Supat Jiranusornkul
Ligustrum lucidum secoiridoid glucosides have been demonstrated to treat various types of diseases such as inflammation, pain, hepatotoxicity and hyperlipidermic as well as tonic for liver and kidney. Matrix metalloproteinases (MMPs) play a key role upon the pathology of photoaging. The present computational study showed that among the six secoiridoid glucosides (ligustroside, lucidumoside A, lucidumoside C, neonuezhenide, oleoside dimethylester, and oleuropein), ligustroside and lucidumoside A competitively inhibit all MMP-1, MMP-3, and MMP-9 activities in the docking models...
August 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29675736/decreased-content-rate-of-synthesis-and-export-of-cholesterol-in-the-brain-of-apoe-knockout-mice
#9
Valéria Sutti Nunes, Patrícia Miralda Cazita, Sérgio Catanozi, Edna Regina Nakandakare, Eder Carlos Rocha Quintão
Apolipoprotein E knockout (apoE-KO) mice present synaptic loss, cognitive dysfunction, and high plasma lipid levels that may affect brain function simulating Alzheimer disease. Plasma and brain sterols were measured in apoE-KO and in wild type control mice on a cholesterol-free, phytosterol-containing diet by gas chromatography coupled to a mass spectrometer. Plasma cholesterol and phytosterols (campesterol and sitosterol) were higher in apoE-KO compared to control mice. Cholesterol precursors (desmosterol and lathosterol) were not detected in plasma of control mice but were present in apoE-KO mice...
August 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29808274/new-ways-of-thinking-about-old-things-the-role-of-o-glcnac-in-cellular-metabolism
#10
EDITORIAL
Chad Slawson
No abstract text is available yet for this article.
June 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29790000/o-glcnac-cycling-in-the-developing-adult-and-geriatric-brain
#11
REVIEW
Olof Lagerlöf
Hundreds of proteins in the nervous system are modified by the monosaccharide O-GlcNAc. A single protein is often O-GlcNAcylated on several amino acids and the modification of a single site can play a crucial role for the function of the protein. Despite its complexity, only two enzymes add and remove O-GlcNAc from proteins, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Global and local regulation of these enzymes make it possible for O-GlcNAc to coordinate multiple cellular functions at the same time as regulating specific pathways independently from each other...
June 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29671171/new-use-for-cetsa-monitoring-innate-immune-receptor-stability-via-post-translational-modification-by-ogt
#12
Walter R Drake, Ching-Wen Hou, Natasha E Zachara, Catherine Leimkuhler Grimes
O-GlcNAcylation is a dynamic and functionally diverse post-translational modification shown to affect thousands of proteins, including the innate immune receptor nucleotide-binding oligomerization domain-containing protein 2 (Nod2). Mutations of Nod2 (R702W, G908R and 1007 fs) are associated with Crohn's disease and have lower stabilities compared to wild type. Cycloheximide (CHX)-chase half-life assays have been used to show that O-GlcNAcylation increases the stability and response of both wild type and Crohn's variant Nod2, R702W...
June 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29594839/o-glcnac-in-cancer-an-oncometabolism-fueled-vicious-cycle
#13
REVIEW
John A Hanover, Weiping Chen, Michelle R Bond
Cancer cells exhibit unregulated growth, altered metabolism, enhanced metastatic potential and altered cell surface glycans. Fueled by oncometabolism and elevated uptake of glucose and glutamine, the hexosamine biosynthetic pathway (HBP) sustains glycosylation in the endomembrane system. In addition, the elevated pools of UDP-GlcNAc drives the O-GlcNAc modification of key targets in the cytoplasm, nucleus and mitochondrion. These targets include transcription factors, kinases, key cytoplasmic enzymes of intermediary metabolism, and electron transport chain complexes...
June 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29524020/cross-regulation-between-mtor-signaling-and-o-glcnacylation
#14
Ninon Very, Agata Steenackers, Caroline Dubuquoy, Jeanne Vermuse, Laurent Dubuquoy, Tony Lefebvre, Ikram El Yazidi-Belkoura
The hexosamine biosynthetic pathway (HBP) integrates glucose, amino acids, fatty acids and nucleotides metabolisms for uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) synthesis. UDP-GlcNAc is the nucleotide sugar donor for O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) processes. O-GlcNAc transferase (OGT) is the enzyme which transfers the N-acetylglucosamine (O-GlcNAc) residue onto target proteins. Several studies previously showed that glucose metabolism dysregulations associated with obesity, diabetes or cancer correlated with an increase of OGT expression and global O-GlcNAcylation levels...
June 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29404877/o-glcnac-a-novel-regulator-of-immunometabolism
#15
REVIEW
Miranda Machacek, Chad Slawson, Patrick E Fields
The rapidly expanding field of immunometabolism focuses on how metabolism controls the function of immune cells. CD4+ T cells are essential for the adaptive immune response leading to the eradication of specific pathogens. However, when T cells are inappropriately over-active, they can drive autoimmunity, allergic disease, and chronic inflammation. The mechanisms by which metabolic changes influence function in CD4+ T cells are not fully understood. The post-translational protein modification, O-GlcNAc (O-linked β-N-acetylglucosamine), dynamically cycles on and off of intracellular proteins as cells respond to their environment and flux through metabolic pathways changes...
June 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29344764/o-glcnacylation-key-regulator-of-glycolytic-pathways
#16
REVIEW
Zachary A Bacigalupa, Chaitali H Bhadiadra, Mauricio J Reginato
Elevated O-GlcNAcylation is emerging as a general characteristic of most cancers. Although O-GlcNAcylation can regulate many cell biological pathways, recent evidence suggests that it is a key regulator of metabolic pathways including glycolysis in cancer cells. This review summarizes our current understanding of how O-GlcNAcylation regulates glycolytic pathways and contributes to alterations in cancer cell metabolism.
June 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29322286/hyperglycemia-and-aberrant-o-glcnacylation-contributions-to-tumor-progression
#17
REVIEW
Andréia Vasconcelos-Dos-Santos, Rafaela Muniz de Queiroz, Bruno da Costa Rodrigues, Adriane R Todeschini, Wagner B Dias
A number of cancer types have shown an increased prevalence and a higher mortality rate in patients with hyperglycemic associated pathologies. Although the correlation between diabetes and cancer incidence has been increasingly reported, the underlying molecular mechanisms beyond this association are not yet fully understood. Recent studies have suggested that high glucose levels support tumor progression through multiple mechanisms that are hallmarks of cancer, including cell proliferation, resistance to apoptosis, increased cell migration and invasiveness, epigenetic regulation (hyperglycemic memory), resistance to chemotherapy and altered metabolism...
June 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29204729/-nutrient-sensing-and-self-renewal-o-glcnac-in-a-new-role
#18
REVIEW
Nikita S Sharma, Ashok K Saluja, Sulagna Banerjee
Whether embryonic, hematopoietic or cancer stem cells, this metabolic reprogramming is dependent on the nutrient-status and bioenergetic pathways that is influenced by the micro-environmental niches like hypoxia. Thus, the microenvironment plays a vital role in determining the stem cell fate by inducing metabolic reprogramming. Under the influence of the microenvironment, like hypoxia, the stem cells have increased glucose and glutamine uptake which result in activation of hexosamine biosynthesis pathway (HBP) and increased O-GlcNAc Transferase (OGT)...
June 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29127647/o-glcnacylation-in-women-s-cancers-breast-endometrial-and-ovarian
#19
REVIEW
Gloria M Trinca, Christy R Hagan
O-GlcNAcylation is emerging as a critical regulatory post-translational modification, impacting proteins that regulate cell division, apoptosis, metabolism, cell signaling, and transcription. O-GlcNAc also affects biological homeostasis by integrating information coming from the environment, such as nutrient conditions and extracellular stimuli, with cellular response. Aberrant O-GlcNAc modulation has been linked to metabolic and neurodegenerative diseases, as well as cancers. While many studies have highlighted the significance of O-GlcNAc in cancer, a specific function for O-GlcNAc during tumorigenesis remains unclear and seems to differ according to cancer type...
June 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29594796/alternative-mitochondrial-respiratory-chains-from-two-crustaceans-artemia-franciscana-nauplii-and-the-white-shrimp-litopenaeus-vannamei
#20
Chrystian Rodriguez-Armenta, Salvador Uribe-Carvajal, Monica Rosas-Lemus, Natalia Chiquete-Felix, Jose Angel Huerta-Ocampo, Adriana Muhlia-Almazan
Mitochondrial ATP is synthesized by coupling between the electron transport chain and complex V. In contrast, physiological uncoupling of these processes allows mitochondria to consume oxygen at high rates without ATP synthesis. Such uncoupling mechanisms prevent reactive oxygen species overproduction. One of these mechanisms are the alternative redox enzymes from the mitochondrial respiratory chain, which may help cells to maintain homeostasis under stress independently of ATP synthesis. To date, no reports have been published on alternative redox enzymes in crustaceans mitochondria...
April 2018: Journal of Bioenergetics and Biomembranes
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